Jiao Gu Lan – Gynostemma pentaphyllum root and aerial parts

Nature: slightly bitter, cold

Enters: Lung, Heart

Actions: Tonifies Lung and Heart Qi; moistens the Lungs, generates body fluids; dispels phlegm; clears heat and toxins; reduces inflammation; benefits cardiovascular system.

Indications:
• Often used to treat chronic disorders with underlying deficiency, including asthma, chronic bronchitis, migraines, neuralgia, impaired function of respiratory and digestive system.
• Heat toxins: swelling, inflammation, pain. Gastric ulcers, duodenal ulcers, hyperlipidemia, nodules, cystitis, herpes zoster, and other conditions with a damp-heat-toxin pattern.
• For ulcers, with Bai hua she she cao, Hai piao xiao, Bei mu. 
• External: mix the powder with water to form a paste for treatment of hyperpigmentation (e.g., liver spots)
• Lowers blood pressure and cholesterol.
• Coronary sclerosis: with Yu jin, Dan shen, Shi chang pu, or Xue Fu Zhu Yu Tang. 
• High cholesterol: with Jue ming zi, Shan zha, Da huang. Appears to lower total cholesterol and triglycerides, and to raise HDL.
• May cause mild GI discomfort when taken on empty stomach
• Possible side effects: fatigue, dizziness, chest congestion, mild fever, sweating, sore throat, rash, increased heart and respiration rate.
• May cause drowsiness / sedation. Appears to have sedative, analgesic, hypnotic effects.
• Has immune stimulating properties
• Anti-cancer effects: inhibits various forms of cancer
• Anti-aging effects: prolongs life expectancy in lab animals
• Appears to support weight loss
• Contemporary use is most often for diabetes, hypertension, obesity.
• May improve insulin resistance, appears to improve blood sugar for Type 2 diabetes
• Potential benefit in Parkinson’s and dementia
• One of many good studies on this herb: Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum

Dose: 5-12 grams in decoction or 0.75-1 gram directly as powder

Thank you to Chinese Medical Herbology and Pharmacology by John and Tina Chen for the majority of this information. This herb does not appear in most TCM materia medicas.

Qi Ye Lian – Schefflera root

Nature: bitter, acrid, warm

Enters: Liver

Actions: Dispels wind-dampness; relieves pain.

Indications:

Bi syndrome: pain in the extremities, especially the joints. Use internally and apply topically in alcohol-based tincture.

Trauma: pain and swelling. Take internally and apply as a tincture or paste/poultice.

Often used as a standalone herb for pain, especially joint pain, as in the pill product Qi Ye Lian Wan.

Dose: 9-15g

Nan Gua Zi – Pumpkin seed (with husk) – “Southern Melon Seeds”

Nature: sweet, neutral

Enters: Stomach, Large Intestine

Actions: Kills parasites (tapeworms [paralyzes the mid-section and tail], roundworms, schistosomes); benefits postpartum fluid metabolism; promotes lactation. 

Indications:

• Tapeworms: take 60g (to 120g) powdered pumpkin seed (just the inside) with cold water. 2 hours later, take a decoction of 60-120g Bing lang. 30 minutes later, take 15g Mang xiao (uncooked) with water.
• Postpartum fluid metabolism dysfunction: swelling of hands and feet.

• Insufficient lactation: take 150-180 grams of the inner seed twice a day. 

• Heat is considered to render this herb ineffective. Thus, it can’t be toasted, fried, or otherwise cooked.  

Michael & Leslie Tierra: Effective for benign prostatic hypertrophy.
John Christopher: Anthelmintic (taeniafuge, vermifuge) [roundworms and tapeworms],
diuretic, nutritive; also for renal problems (urinary).
IBIS: Vermifuge, diuretic, nutritive.
• Dosage of raw seeds: 200-400 g (Weiss, p. 120).
• Therapy: parasites, nausea, motion sickness, benign prostatic hypertrophy.

Dose: 30-60 grams

Lei Wan – Omphalia sclerotium / Polyporus mylittae / “Thunder Ball”

Nature: bitter, cold, slightly toxic

Enters: Large Intestine, Stomach

Actions: Kills parasites (primarily tapeworms, but also hookworms, roundworms).

Indications:

• For tapeworms, the herb can be taken alone, at a dose of 12-18g powder, 3 times daily with water, after meals.
• The herb must be crushed.
• The herb is less effective when cooked, and is therefore usually taken in pills and powders.
Heiner Freuhauf: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.

Dose: 6-9 grams (or 12-18g taken alone as powder)

Ku Lian Pi / Ku Lian Gen Pi – Melia root bark / China Tree root bark

Nature: bitter, slightly toxic, cold

Enters: Liver, Spleen

Actions: Strongly kills parasites and fungi (particularly roundworms, hookworms, pinworms, vaginal trichomonas, scalp fungus, scabies).

Indications:

• Scabies: mix with vinegar and apply topically.
• Pinworms: use as enema and anal wash with Bai bu, Wu mei.
• Roundworms, hookworms: combine with Bing lang.
• Use as a wash for fungal infections. Alcohol extractions of the herb are much more effective against dermatomycoses than are water extractions.
• Contraindicated with hepatic disease. Caution with weak constitution, with a history of gastric or peptic ulcers, or in any patient in whom vomiting would be disastrous (e.g. when there are esophageal varices).

• The bark of the stem of this plant (Ku lian mu pi) has similar effects, but is weaker.

Dose: 1-15 grams (up to 60g alone)

Fei Zi – Torreya seed

Nature: sweet, astringent, neutral

Enters: Large Intestine, Lung, Stomach

Actions: Kills parasites (various intestinal, including tapeworm, hookworm, pinworm, roundworm); moistens the Lungs, stops coughing; mild laxative.

Indications:

• Hookworms: with Bai bu.
• Roundworms: with Shi jun zi.
• Pinworms: with Bian xu.
• Tapeworms: with Bing lang.
• Lung dryness: mild cough.
• This is a safe, non-toxic herb, and it does not harm the stomach Qi.
• Most effective when dry-fried and taken directly (rather than in
decoction).

Dose: 9-15g (up to 30g or more)

Bing Lang – Betel nut / Areca seed

Nature: bitter, acrid, warm

Enters: Stomach, Large Intestine

Actions: Kills parasites (particularly tapeworms [pig], and also hookworms, pinworms, roundworms, flukes, Fasciolopsis); reduces accumulation, eliminates food retention; regulates Qi, promotes Qi circulation; promotes urination; slightly promotes bowel movement..

Indications:
• Parasitic infection. This does not kill tapeworms, but paralyzes the head and upper body. It is often combined with Nan gua zi, which paralyzes the rear end of the tapeworm. Since this herb has a slight action to promote bowel movement, it does not need to be combined with a purgative to expel the parasites.
• Food retention and Qi stagnation in the stomach and large intestine: distention, constipation.
• Retention of harmful fluid: edema, swollen and painful legs.
• Malarial disorders.
• This herb can be drunk at a cool temperature to reduce the possibility of side effects.
• For best results against parasites, soak the herb in water for a few hours before decocting.
• This herb is an enormously popular recreational drug in India (mixed with burnt lime, areca leaf, and other additives and flavorings which may alter its effect): stimulates cholinergic receptors, especially those causing salivation; possible aphrodisiac; stimulates peristalsis, bronchoconstriction, bradycardia. Habitual use increases the appetite, diminishes the sense of taste, may cause diarrhea, increases risk of periodontal disease, and stains the oral cavity red.
Heiner Freuhauf: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.
Dui Yao (Phillipe Sionneau): Breaks and downbears the Qi.
• With Mu xiang to move the Qi, disperse food stagnation, and stop pain.
For such indications as:

1. Lack of appetite, abdominal and epigastric distention and pain
aggravated by pressure, difficult defecation or dry stools due to food
stagnation in the stomach and intestines. (Bing lang should be stir-fried
until scorched.)
2. Dysentery or diarrhea with tenesmus and abdominal pain due to Qi
stagnation. (Use scorched Bing lang and roasted Mu xiang.)
3. Constipation or difficult defecation due to Qi stagnation. (Use
scorched Bing lang.)
• With Nan gua zi to expel tapeworms (and other intestinal parasites). For this indication, 15-100g Bing lang and 30-120g Nan gua zi are used. Two hours after drinking a decoction of these two herbs for tapeworm, a decoction of 10-20g Da huang is taken.

Hong-Yen Hsu (Oriental Materia Medica): Antiviral, antifungal; antimydriatic effect; stimulates parasympathetic nervous system; stimulates intestinal peristalsis.

Dose: 6-12g (60-120g alone for tapeworms)

Herbs that Kill Parasites (notes for this category)

• These herbs should be taken on an empty stomach so the parasites are hungry.
• Temporarily discontinue herbs if a patient develops a fever or severe abdominal pain.
• The non-purgative herbs in this category usually combined with a purgative to discharge the dead parasites.
• Other anti-parasitic herbs to consider: da suan, chuan lian zi, hua jiao, lu hui, ku shen, bai bu, wu me, shi liu pi,
xiong huang, xian he cao, bian xu, more…

Also see Heiner Freuhauf’s discussion and list of herbs for the complex concept of “Gu” parasites, which encompasses a broader range of potential infectious agents and difficult-to-diagnose conditions.

Here are some interesting notes on treating parasites from John Christopher (“old school” 20th century Western herbalist) from “The School of Natural Healing”:

The three most common types of worms found in the body (in the West) are: the thread or seat worms (Oxyuris vermicularis), the round worms (Ascaris lumbricoides-lumbrici), and the tape worms (Taeince-Taenia solium, bothriocephalus latus). There are also other less-common worm types that enter the body, such as hook worms for which thymol [from essential oil of Thyme] and oil of Chenopodium duodenale (American Wormseed) are specifics, and those of unclean pork, etc., which thrive on toxic conditions in the body.

The thread or seat worm is rather easily destroyed or expelled because it is usually found in the lower bowel and does
not adhere to the intestinal wall. Herbs such as cathartics, astringents, Aloes, Quassia, Calumba, apple cider vinegar,
etc., are effective against these intestinal vermin.

The roundworm is most likely to be found in and often clinging to the intestinal wall, and can cause considerable harm
and physical discomfort, especially to children. If roundworms are not checked, they may increase to the point that
they enter the stomach, and even travel up the esophagus to the pharynx, with most unpleasant and upsetting results.
You can see roundworms in the stools, and you can also know you have them because they greatly disturb the balance
of the stomach. The anthelmintic herbs are particularly useful and beneficial to eliminate roundworms and tapeworms.
The anthelmintic agents are classed as to their action against the worm parasites: Vermifuges cause the expulsion of
worms from the body. Vermicides kill worms in the body. Taeniafuges cause the expulsion of tapeworms from the
body. Taeniacides kill tapeworms in the body.

The difference in the action of a worm medicine often depends on the medicinal dosage and how soon after
administration the bowels are moved – thus a large dose of an anthelmintic, if it remains in the intestine, will destroy,
while a smaller dose will merely expel the worm. Almost all anthelmintics are potent and must be respected as such;
and concentrated preparations must always be used in wisdom. Generally, in the case of thread or seat worms, an
enema is sufficient; and, in the case of round worms, follow the following procedure:

Go on a three day cleanse/fast drinking only one type of juice and distilled water and take the anthelmintic morning
and night, preferably with Wormwood. On the morning of the fourth day, drink 6-8 ounces of Senna [Fan xie ye] tea alone to cleanse and purge the bowel of the parasites (other suitable cathartics are also acceptable).

The tapeworm is somewhat more obstinate, but the foregoing procedure will also work, using Male Fern [Guan zhong]
or Pomegranate [Shi Liu Pi, Shi Liu Gen Pi] as the anthelmintic. Continue taking the remedy a few days after the
worm sections have ceased to pass, and use Lobelia along with an antibilious cathartic.

[Dr. Shook:] Doctors generally have the patient fast for a day or two before taking tapeworm remedies, but this is
unnecessary, because the worm, being a parasite, cannot be starved. This only makes the patient feel weak and
nauseated, and when he finally takes the medicine on a starved stomach, he may throw it up. A far better way, from
our experience, is to advise the patient to eat, for a day or so, foods the tapeworm dislikes, such as onions, garlic,
pickles, and salted fish. This weakens the worm and tends to loosen its grip, so that when the medicine is taken, the
tapeworm can be expelled more easily.

Guiding Herbs

These herbs can guide a formula to a particular channel, organ, or region of the body.

In many cases guiding herbs are instrumental in the central effect of classical formula.

From Dui Yao by Philippe Sionneau:

  • Lung channel: Jie geng, Sheng ma, Cong bai, Bai zhi
  • Large Intestine channel: Da huang, Bai zhi, Sheng ma, Shi gao
  • Stomach channel: Bai zhi, Sheng ma, Shi gao, Ge gen
  • Spleen channel: Bai zhu, Ge gen, Cang zhu, Sheng ma, Bai shao, Gan jiang, Sheng jiang, Da zao, Gan cao
  • Heart channel: Huang lian, Xi xin
  • Small Intestine channel: Mu tong, Deng xin cao, Gao ben, Huang bai
  • Bladder channel: Ge gen, Qiang huo, Gao ben
  • Kidney channel: Du huo, Rou gui, Zhi mu, Xi xin
  • Pericardium channel: Chai hu, Mu dan pi
  • San Jiao channel: Upper Jiao: Zhi zi, Gui zhi, Wan qian, Di gu pi / Middle Jiao: Qing pi / Lower Jiao: Fu zi, Chen xiang, Niu xi
  • Gallbladder channel: Chai hu, Qing pi
  • Liver channel: Wu zhu yu, Chai hu, Chuan xiong, Qing pi

Herbs That Guide to Particular Regions of the Body

  • Exterior/Skin – Ma huang
  • Extremities – Sang zhi, Gui zhi, Chuan wu
  • Upper body – Chai hu
  • Lower body – Niu xi
  • Head – Feng feng, Tian ma, Chuan xiong
  • Vertex of Head – Gao ben
  • Back of Head – Qiang huo
  • Sinuses – Cang er zi, Xin yi hua
  • Forehead – Bai zhi
  • Temples – Man jing zi
  • Throat – Jie geng, Niu bang zi, Chan tui
  • Neck & Shoulders – Qiang huo, Gou teng, Ge gen
  • Shoulders – Jiang huang (also upper extremity)
  • Right Shoulder (Chronic) – Huang qi
  • Left Shoulder (Chronic) – Dang gui
  • Chest – Chai hu, Xiang fu, Yu jin, Gua lou pi
  • Upper Back – Chuan xiong, Ma huang (indirectly, use chest herbs)
  • Spine – Gou ji
  • Flanks – Chuan lian zi
  • Lower Back – Du zhong, Du huo
  • Lower Abdomen – Wu yao, Chuan lian zi
  • Urethra – Gan cao shao (tips)
  • Testes – Li zhi he
  • Legs – Niu xi, Mu gua
  • Knees – Niu xi, Gu sui bu, Xu duan
  • Heels – Bu gu zhi
  • Channels, Network Vessels, Muscles and Sinews: Di long, Chuang shan jia, Luo shi teng

Herbs That Enter the Eight Extraordinary Vessels

Herbs Ascribed to the Extraordinary Vessels by Eric Brand. From Eric Brand’s Blog. Posted September 16th,
2010. Accessed October 1, 2010. The source material for this blog comes from the Qing dynasty text “De Pei
Ben Cao”, found in Chinese @ http://www.zysj.com.cn/lilunshuji/depeibencao/689-16-0.html#m0-0

  • Bai shao: Governs yang wei (yang linking vessel) [aversion to] cold and heat [effusion] and dai mai (girdling vessel) abdominal pain
  • Lu hui: Governs disease in the chong mai (thoroughfare vessel), counterflow qi and abdominal urgency
  • Ba ji tian: Enters the chong mai (thoroughfare vessel)
  • Bing lang: Governs chong mai (thoroughfare vessel) counterflow qi and abdominal urgency
  • Wu zhu yu: Governs chong mai (thoroughfare vessel) counterflow qi and abdominal urgency
  • Dang gui: Governs chong mai (thoroughfare vessel) disease with counterflow qi and abdominal urgency; dai mai (girdling vessel) disease with abdominal fullness; broad lumbus as if sitting in water
  • Huang bai: Governs chong mai (thoroughfare vessel) counterflow qi
  • Bai zhu: Governs chong mai (thoroughfare vessel) disease, counterflow qi and abdominal urgency, umbilical and abdominal disease
  • Xiang fu: Enters the chong mai (thoroughfare vessel)
  • Chuan xiong: Moves in the chong mai (thoroughfare vessel)
  • Huang qin: Moves in the chong mai (thoroughfare vessel)
  • Bie jia: Moves in the chong mai (thoroughfare vessel)
  • Mu xiang: Governs chong mai (thoroughfare vessel) disease, counterflow qi and abdominal urgency
  • Gou qi zi: Supplements essence-blood of the chong mai (thoroughfare vessel) and du mai (governing vessel)
  • Huang qi: Governs yang wei (yang linking vessel) disease with [aversion to] cold and heat [effusion], and du mai (governing vessel) disease with counterflow qi and abdominal urgency
  • Cang er zi: Moves in the du mai (governing vessel)
  • Xi xin: Governs du mai (governing vessel) disease, stiffness of the spine and reversal
  • Fu zi: Governs du mai (governing vessel) disease, stiffness of the spine and reversal
  • Goat (or sheep) spine: Frees the du mai (governing vessel)
  • Bai guo: Frees the du mai (governing vessel)
  • Lu jiao shuang: Frees qi abiding in the du mai (governing vessel)
  • Lu rong: Frees the essence chamber of the du mai (governing vessel)
  • Lu jiao jiao: Warms the blood of the du mai (governing vessel)
  • Gui ban: Frees the ren mai (controlling vessel)
  • Gao ben: Governs du mai (governing vessel) stiffness of the spine and reversal
  • Gui zhi: Moves in the yang wei (yang linking vessel)
  • Fang ji (Stephania): Enters the yang qiao mai (yang springing vessel)
  • Rou gui: Frees the yang qiao mai (yang springing vessel) and du mai (governing vessel)
  • Chuan shan jia: Enters the yang qiao mai (yang springing vessel) and yin qiao mai (yin springing vessel)
  • Hu gu: Enters the yang qiao mai (yang springing vessel) and yin qiao mai (yin springing vessel)
  • Xu duan: Governs dai mai (girdling vessel) disease
  • Ai ye: Governs dai mai (girdling vessel) disease with abdominal fullness, and broad lumbus as if sitting in water
  • Long gu: Treats dai mai (girdling vessel) disease
  • Wang bu liu xing: Frees the chong mai (thoroughfare vessel) and ren mai (controlling vessel)
  • Ze lan: Regulates disease damaging the eight [extraordinary] vessels
  • Sheng ma: Relaxes retraction and tension in the dai mai (girdling vessel)
  • Gan cao: Harmonizes counterflow of the chong mai (thoroughfare vessel), and relaxes tension in the dai mai (girdling vessel)
  • Dan shen: Boosts the chong mai (thoroughfare vessel) and ren mai (controlling vessel)

More Channel Guiding Properties from Dr. Tian De Yang

Liver, Kidney and All 8 Extras:
Gou Qi Zi
Sha Ren Zi
Du Zhong
Niu Xi
Xu Duan
Sheng Di Huang
Hei Zhi Ma
Sang Shen
Tu Si Zi
Shan Zhu Yu
Nu Zhen Zi
Hao Ren Zao
Suo Yang
Fu Pen Zi
Ling Ci Shi
Long Gu

Yang Wei Mai:
Gui Zhi
Bai Shao
Huang Qi

Yin Wei Mai:
Gui Zhi
Bai Shao
Huang Qi
Dang Gui
Chuan Xiong

Ren/Du:
Lu Rong
Gui Ban
Bie Jia
E Jiao
Zi He Che

Du Mai:
Lu Jiao
Yang Gou (sheep
vertebra)
Lou Shen Cao (deer
teeth herb)
Fu Zi
Rou Gui
Cang Er Zi
Gao Ben
Gou Qi Zi
Huang Qi

Chong/Ren Mai:
Gui Ban
Wang Bu Liu Xing
Bie Jia
Ba Ji Tian
Xiang Fu
Chuan Xiong
Mu Xiang
Dang Gui
Cang Zhu
Bai Zhu
Wu Zhu Yu
Gou Qi Zi
Dang Shen

Regulate and Strengthen Chong Mai Qi and Blood:
Chuan Lian Zi
Xiang Fu
Yi Mu Cao
Jiang Xiang

Stomach and Chong Mai:
Dang Gui
Dan Shen
Chuan Xiong
Cang Zhu
Wu Zhu Yu
Ban Xia
Hou Po

Dai Mai: 
Wu Wei Zi
Qian Shi
Lian Zi
Jing Ying Zi
Dang Gui
Bai Shao
Xu Duan
Ai Ye
Sheng Ma
Wu Wei Zi

Yin/Yang Qiao Mai:
Rou Gui
Fang Ji
Chuan Shan Jia
Hu Gu

Herbs that Enter the Chong and Ren

From The Chong and Ren Channels in Gynecology, Selected Writings from Zhu Xiao Nan’s Gynecological
Experience, People’s Medical Publication House, Beijing, 2005, Pages 165 – 172
Translation by: Diana Hester, Laura Camus, Ryan Kirkby

Herbs that Enter the Chong Mai

Tonify Qi of the Chong Mai:
Wu Zhu Yu
Ba Ji Tian
Gou Qi Zi
Gan Cao
Lu Xian
Lu Rong
Zi He Che
Rou Cong Rong
Zi Shi Ying
Du Zhong
Tonify Blood of Chong Mai:
Dang Gui
Bie Jia
Dan Shen
Chuan Xiong
Descend Counterflow of Chong Mai:
Mu Xiang
Bing Lang
Consolidate Chong Mai:
Shan Yao
Lian Zi

Herbs that Enter the Ren Mai

Tonify Qi of Ren Mai:
Lu Rong
Fu Pen Zi
Zi He Che
Tonify Blood of Ren Mai:
Gui Jia
Dan Shen
Consolidate Ren Mai:
Bai Guo

Herbs that Enter the Extraordinary Vessels

The following is excerpted from Ye Tian-shi’s Medicinals Entering the Extraordinary Vessels
by By Bob Flaws, Dipl. Ac. & C.H., FNAAOM

Retrieved from:
http://bluepoppy.com/cfwebstore/index.cfm?fuseaction=feature.display&feature_ID=91&ParentCat=182

Governing vessel (Du mai):

The governing vessel is the sea of yang and mainly treats diseases located in the shao yin. Ye’s choice of
medicinals entering the governing vessel were Cornu Parvuum Cervi (Lu Rong), Gelatinum Cornu Cervi (Lu
Jiao Jiao), and Cornu Degelatinum Cervi (Lu Jiao Shuang). According to Ye, Lu Rong strengthens governing
vessel yang, Lu Jiao Jiao supplements kidney vessel blood, and Lu Jiao Shuang frees the flow of governing
vessel qi. Because the governing vessel and the foot tai yang are mutually connected, these can be combined
with Radix Lateralis Praeparatus Aconiti Carmichaeli (Fu Zi), Cortex Cinnamomi Cassiae (Rou Gui), dry
Rhizoma Zingiberis (Gan Jiang), Fructus Zanthoxyli Bungeani (Chuan Jiao), Ramulus Cinnamomi Cassiae (Gui
Zhi), Herba Asari Cum Radice (Xi Xin), and Radix Et Rhizoma Ligustici Chinensis (Gao Ben).

Conception vessel (Ren mai):

The conception vessel is the sea of yin and mainly treats disease located in the jue yin. Ye’s choice of medicinals
entering the conception vessel were Gelatinum Corii Asini (E Jiao), Carapax Amydae Sinensis (Bei Jia),
Placenta Hominis (Zi He Che), Flouritum (Zi Shi Ying), Folium Artemisiae Argyii (Ai Ye), Radix Salviae
Miltiorrhizae (Dan Shen), and Fructus Rubi Chingii (Fu Pen Zi). Because the conception vessel and the liver
and kidneys are mutually connected, these can be combined with Rhizoma Anemarrhenae Aspheloidis (Zhi
Mu), Cortex Phellodendri (Huang Bai), Radix Scrophulariae Ningpoensis (Xuan Shen), and uncooked Radix
Rehmanniae (Sheng Di) to downbear kidney fire.

Penetrating vessel (Chong mai):

The penetrating vessel is the sea of blood and mainly treats the jue yin and yang ming. Ye’s choice of medicinal
entering the penetrating vessel was mainly Flouritum (Zi Shi Ying). Other medicinals which can be added are
cooked Radix Rehmanniae (Shu Di), Fructus Lycii Chinensis (Gou Qi Zi), Semen Astragali Complanati (Sha
Yuan Zi), Placenta Hominis (Zi He Che), Fructus Schisandrae Chinensis (Wu Wei Zi), Haemitium (Dai Zhe
Shi), Semen Juglandis Regiae (Hu Tao Ren), Radix Angelicae Sinensis (Dang Gui), Carapax Amydae Sinensis
(Bei Jia), Herba Cistanchis Deserticolae (Rou Cong Rong), Cortex Eucommiae Ulmoidis (Du Zhong), Radix
Dioscoreae Oppositae (Shan Yao), and Radix Morindae Officinalis (Ba Ji Tian). Because the penetrating vessel
and the liver and kidneys are mutually connected, these can be combined with Fructus Meliae Toosendan
(Chuan Lian Zi), Lignum Dalbergiae Odoriferae (Jiang Xiang), Fructus Evodiae Rutecarpae (Wu Zhu Yu),
Fructus Foeniculi Vulgaris (Xiao Hui Xiang), Sclerotium Poriae Cocos (Fu Ling), Semen Biotae Orientalis (Bai
Zi Ren), Rhizoma Cyperi Rotundi (Xiang Fu), and Cortex Phellodendri (Huang Bai)

Girdling vessel (Dai mai):

Ye’s choice of medicinals entering the girdling vessel were Radix Angelicae Sinensis (Dang Gui), Flouritum (Zi
Shi Ying), Semen Astragali Complanati (Sha Yuan Zi), Os Sepiae Seu Sepiellae (Wu Zei Gu), Radix Albus
Paeoniae Lactiflorae (Bai Shao), cooked Radix Rehmanniae (Shu Di), and Fructus Lycii Chinensis (Gou Qi Zi).
These may be combined with the following medicinals for the purposes of securing and gathering: Radix
Dioscoreae Oppositae (Shan Yao), Semen Euryalis Ferocis (Qian Shi), Fructus Rosae Laevigatae (Jin Ying Zi),
Fructus Rubi Chingii (Fu Pen Zi), Ootheca Mantidis (Sang Piao Xiao), Os Draconis (Long Gu), Concha Ostreae
(Mu Li).

Linking vessels (Wei mai):

Yang linking vessel disease mostly involves cold and heat. Yin linking vessel disease mostly involves heart
pain. Treatment resides in the middle burner. For linking vessel diseases, Ye commonly used Dang Gui Gui Zhi
Tang (Dang Gui & Cinnamon Twig Decoction) plus Cornu Degaltinum Cervi (Lu Jiao Shuang), Semen
Astragali Complanati (Sha Yuan Zi), and Fructus Lycii Chinensis (Gou Qi Zi). He commonly combined these
with Fructus Foeniculi Vulgaris (Xiao Hui Xiang), Semen Biotae Orientalis (Bai Zi Ren), and Sclerotium Poriae
Cocos (Fu Ling) to free the flow of the network vessels.

Springing vessels (Qiao mai):

Yang springing vessel disease mostly involves slack yin (i.e., the medial side of the body) and tense or cramped
yang (the lateral side of the body), while yin springing vessel disease usually involves slack yang and tense or
contracted yin. Treatment resides in the liver and kidneys. For springing vessel diseases, Ye commonly used
Radix Albus Paeoniae Lactiflorae (Bai Shao), Fructus Corni Officinalis (Shan Zhu Yu), cooked Radix
Rehmanniae (Shu Di), Plastrum Testudinis (Gui Ban), Fructus Tritici Aestivi (Huai Xiao Mai), Fructus Zizyphi
Jujubae (Da Zao), mix-fried Radix Glycrrhizae (Gan Cao), Fructus Schisandrae Chinensis (Wu Wei Zi). For
yang springing vessel emptiness (kong), Ye commonly used Plastrum Testudinis (Gui Ban), cooked Radix
Rehmanniae (Shu Di), Cortex Phellodendri (Huang Bai), Sclerotium Poriae Cocos (Fu Ling), Fructus Corni
Officinalis (Shan Zhu Yu), Fructus Schisandrae Chinensis (Wu Wei Zi), and Radix Polygalae Tenuifoliae (Yuan
Zhi). For yin springing vessel emptiness (kong), Ye commonly used Radix Albus Paeoniae Lactiflorae (Bai
Shao), Fructus Corni Officinalis (Shan Zhu Yu), Hallyositum Album (Bai Shi Ying), Fructus Tritici Aestivi
(Huai Xiao Mai), Fructus Zizyphi Jujubae (Da Zao), and mix-fried Radix Glycyrrhizae (Gan Cao).

Guan Zhong / Mian Ma Guan Zhong / Dryopteris crassirhizoma root & rhizome OR Woodwardia OR Osmunda OR Matteuccia (or other plants) / Shield Fern

bitter, slightly cold

Enters: Liver, Spleen

Actions: Kills parasites (lice and various intestinal parasites, including hookworms, roundworms, tapeworms, pinworms); clears heat; eliminates toxicity; cools the blood; stops bleeding (charred).

Indications:
• Heat in the blood: rashes, eruptions, epistaxis, hematemesis, hemafecia, and especially uterine bleeding. The herb should be charred when used to stop bleeding.
• Heat and toxicity: mumps, epidemic disease, sores.
• Wind-heat EPI.
• Also for alopecia, head sores.
• Antiviral: influenza. Dryopteris (Dong bei guan zhong) has been taken as a preventive measure during flu epidemics. Currently used as a preventative in formulas for corona virus.
• Stimulates contraction of uterus. Used in post-partum, post-miscarriage, and post-surgical uterine bleeding.
• Do not take with fatty food: one toxic component (filmarone) is usually not absorbed from the GI tract unless the herb is taken with a very fatty meal.
John Christopher: Anthelmintic (taeniafuge, vermifuge), astringent, tonic, vulnerary.
• Tapeworms, roundworms, seat worms, pinworms.
• Wounds, rickets.

Dose: 6-15g

Shen Jin Cao (Jin Bu Huan) – Lycopodium serratum – “Stretch Sinew Herb” (“More Valuable than Gold”)

Nature: acrid, bitter, warm

Enters: Spleen, Liver, Kidney

Actions: Dispels wind, eliminates dampness; relaxes the sinews, invigorates the channels, promotes blood circulation.

Indications:

• Wind damp painful obstruction (Bi) especially when there are problems flexing and extending the joints.
• Swelling and pain due to trauma (internal or external) with blood stasis.
• Difficulty bending and stretching the body with hemiplegia.
• Contains Huperzine-A and B
ITM on Huperzine in Alzheimer’s: 

Huperzine, an anticholinesterase alkaloid, is divided into two chemical species, huperzine A and huperzine B, which have similar effects but differing activity levels (huperzine A being about 10 times as strong as huperzine B). Huperzine A was first isolated from the Chinese herb Lycopodium serratum in 1980 at the Zhejiang Academy of Medical Sciences and the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences. Huperzine B was isolated five years later. The plant source, originally called Qian Ceng Ta, meaning thousand-layers pagoda (referring to the tall multi-leafed appearance of the plant), is also known in China as Jin Bu Huan, a term meaning “more valuable than gold,” usually applied to plants that have potent analgesic actions. This herb should not be confused with the patent remedy called Jin Bu Huan made from tetrahydropalmatine. The plant has been reclassified botanically as Huperzia serrata from the new family Huperziaceae, rather than from the closely related family Lycopodiaceae. It is reported that the Lycopodiaceae have two medicinal genera: Lycopodium (now Huperzia) and Phlegmariurus. A common constituent is the alkaloid fordine, which is found in 14 species of Huperzia and has similar action to the huperzines.

Huperzia, as it is now called, contains a wide variety of alkaloids, including lycodoline, lycoclavine, and serratinine, as well as the huperzines. The alkaloids are of a unique structure and have been called Lycopodium alkaloids. In general, they are comprised of four rings, though one of the rings may be opened. The huperzines, like many of the other lycopodium alkaloids, contain a nitrogen within one of the rings and an NH2 group attached to the ring structure (some of the Lycopodium alkaloids contain only a nitrogen within the ring structure).

Huperzia is not much used as a crude herb in Chinese medicine: the dominant application is for blood disorders caused by trauma or acute ailment, such as hematamesis caused by overstrain, bruises, hemorrhoids, and lung abscess. In addition to alkaloids, it contains triterpenoids. Huperzines and other isolated alkaloids are increasingly used in Chinese medicine as an alternative to crude herb preparations.

PHARMACOLOGY AND CLINICAL APPLICATIONS OF HUPERZINE

Huperzines A and B reversibly inhibit cholinesterase; huperzine A has a stronger action than huperzine B, which in turn has a stronger action than galanthamine (an alkaloid from Lycorus radiata that has been used for its anticholinesterase activity). Huperzine A has substantially stronger anticholinesterase activity than physostigmine or neostigmine (chinchona alkaloids obtained from Physostigma venenosum; neostigmine is a common drug for treatment of myasthenia at a dose of 1-2 mg by IM or 0.5 mg IV; physostigmine is also an approved anticholinesterase drug), but huperzine B is three to five times weaker than physostigmine. Huperzines A and B have greater effect on acetylcholinesterase (AChE) than on butyrocholinesterase (BuChE). Huperzine A, because of its cholinesterase inhibiting activity, has been used in myasthenia gravis patients in China, with apparent success.

Both huperzine A and B have been shown to have memory-enhancing activities in animals. At 0.075 mg/kg for huperzine A or 0.5 mg/kg for huperzine B, IP administration to mice significantly facilitated spatial discrimination learning in a Y-maze study. At slightly higher doses (0.075-0.125 mg/kg for A and 0.6-0.8 mg/kg for B) the huperzines given prior to exposure of mice to carbon dioxide prevented hypercapnia-induced impairment of learning. Memory retention and retrieval could be enhanced in animals when the alkaloids were given immediately or 6-12 hours after training. Substantially lower or higher doses of huperzines are not effective. Huperzine has been used for Alzheimer’s and senile dementia with positive results. In a double-blind trial with a group of 56 patients suffering from multi-infarct dementia or senile dementia and a group of 104 patients with senile and presenile memory loss, huperzine A was demonstrated to be effective for improving memory. It was given by intramuscular injection, 0.05 mg twice daily for four weeks to the first group and 0.03 mg twice daily for two weeks to the second group. The only side effect was slight dizziness experienced by a few patients. In rats, fordine, at 0.01-0.04 mg/kg IP, speeds up conditioned avoidance responses, reverses impairment of conditioned avoidance response, and antagonizes hippocampal and cortical EEG changes induced by quinuclidinyl benilate.

Huperzine A has been evaluated at the Mayo Clinic in Jacksonville, Florida. According to Alan Kozikowski, a chemist who is heading the research there, Huperzine A is more effective and more specific than tacrine, another anticholinesterase drug. Interneuron Pharmaceuticals in Lexington, Mass. is testing Huperzine A in human clinical trials.

Dose: 9-15g

 

 

Examine.com on Huperzine-A:

Huperzine-A is a compound extracted from the herbs of the Huperziceae family. It is known as an acetylcholinesterase inhibitor, which means that it stops an enzyme from breaking down acetylcholine which results in increases in acetylcholine.

Acetylcholine is known as the learning neurotransmitter, and is involved in muscle contraction as well. Increasing levels of acetylcholine is routinely used as a technique amongst weight-lifters and scholars.

Huperzine-A appears to be a relatively safe compound from animal studies of toxicity and studies in humans showing no side-effects at dosages routinely supplemented with. Huperzine-A is in preliminary trials for usage in fighting Alzheimer’s Disease as well.

  • Huperzine-A appears to be water-soluble, and taking with food is not needed
  • Although its initial spike is quick, it appears to have a long half-life; the pharmacokinetic profile might change when changing dosages though.

Supplementation of huperzine-A tends to be in the range of 50-200mcg daily, and while this can be divided into multiple dosages throughout the day it tends to be taken at a single dose. Supplementation of huperzine-A does not require food to be coingested with it and can be taken in a fasted state.

Cycling of huperzine-A tends to be used since the half-life exceeds 24 hours, and although a ‘cycle’ of huperzine-A tends to last 2-4 weeks followed by a break the optimal cycle length is not yet known.

Pu Huang – Cattail / Typha / Bulrush Pollen

Nature: sweet, astringent, neutral

Enters: Liver, Pericardium, Spleen, Heart

Actions: Promotes blood circulation, dispels blood stasis; stops bleeding by astringing; slightly promotes urination.

Indications:

• Blood stasis pain: chest, abdominal, menstrual , including postpartum abdominal pain. Recently for angina pectoris.
• Bleeding: hemoptysis, hematemesis, hemafecia, hematuria (slightly promotes urination for bloody urine due to heat in the bladder), epistaxis, uterine bleeding, hematochezia, heavy menstrual bleeding, subcutaneous bleeding, external trauma. For dysmenorrhea, often combined with Wu Ling Zhi.
• Can contract the uterus: to stop abnormal uterine bleeding and for severe postpartum abdominal pain.
• Lowers cholesterol.
• Probably decreases thrombin time and increases platelet count.
• Use the herb raw to dispel blood stasis and relieve pain.
• Use the herb toasted / charred to stop bleeding.
• If the herb is to be decocted, it should be placed in a tea bag.
• Can be used externally or internally.
Chen & Chen in Chinese Medical Herbology & Pharmacology: Useful for peptic ulcer. Research shows anti-inflammatory effect; increases intestinal peristalsis, relieves enteritis; raises HDL, lowers total cholesterol (also lowered triglycerides in one study of 30g/day in divided doses; improves flow to coronary arteries;  One study showed relief of eczema and its itching by applying Pu Huang powder to it daily. It’s possible that this herb’s antiplatelet action may cause it to interfere with anticoagulant or antiplatelet medications.
Hong-Yen Hsu (Oriental Materia Medica): Strong anti-tubercular effect; diuretic.

Dose: 4.5-12g

Gu Parasite Herbs From Heiner Fruehauf

Excerpted from LYME DISEASE: AN IN DEPTH INTERVIEW WITH HEINER FRUEHAUF (click for entire article)

Fruehauf: “To treat Lyme-like diseases, the Gu classics therefore outline an approach that incorporates herbs with wind-dispelling effect—a relatively novel concept, since most of us have been conditioned to use winddispelling herbs only for acute disorders and for short periods of time.

The first and most important category of traditional brain Gu treatment, therefore, does not feature botanicals considered to be directly anti-parasitic, such as Qinghao. It offers herbs that disperse wind, and at the same time limit damage to the patient’s source qi (like Mahuang, ephedra), thus making them suitable for long term use. These herbs should further be combined with “internal herbs,” such as anti-parasitic qi tonics, blood tonics, and yin tonics. This pairing will make them even safer for long-term use.

The next set of categories consists of anti-parasitic and immune-modulating herbs that are generally considered to be tonic,  particularly for the damaged blood, qi, and yin aspects of the body. I have discussed these categories at length in previous interviews and articles on the general treatment of Gu syndrome.

The blood and yin tonic categories are of particular interest in the treatment of Lyme. Note that China’s first single herb classic, Shen Nong bencao jing (Shen Nong’s Materia Medica), lists the famous blood tonic Danggui (Angelica sinensis) as an herb that treats malaria and other jungle fevers. Chuanxiong (Ligusticum wallichii) and the rarely used leaf of the same plant (Miwu), are particularly effective in alleviating headaches. Headaches are, of course, a major symptom for patients suffering from inflammation of the brain. Miwu is unfortunately not available in the West, so I began to manufacture it into a powdered extract myself, and import them under the Classical Pearls label.

There is also a category of herbs for body pain, which is another common symptom for Lyme patients. In this category, you have Xuduan (Dipsacus), which is often used as a Lyme treatment in the form of Teasel root tincture by naturopaths. I particularly like to use Wujiapi (Acanthopanax) for spirochetes. I also use Shenjincao (Lycopodium) for arthritic body pain. I use Shenjincao not only for rheumatoid arthritis, which is often a sequella of Lyme, but also preventatively to guard against the emergence of  rheumatic conditions in the future.

Another category of herbs addresses the notorious biofilm, a slimy matrix in which micro-organisms tend to embed themselves. This self-produced barrier enables the pathogens to evade attack by the immune system, and escape the noxious effect of  anti-parasitic substances. This protective film is difficult to break open, transform, or expel. The ancient Chinese approach to Brain Gu pathogens appears to have accounted for this ohenomenon, since Gu Formulas regularly contain aromatic herbs that move qi and blood and are simultaneously anti-parasitic, such as Sanleng (Sparganium), Ezhu (Zedoria), Yuzhu (Curcuma) and Zelan  (Lycopus). In addition, the earthworm Dilong (Lumbricus), represents the natural precursor to the extract Lumbrokinase, which some naturopaths and MDs now use for the specific purpose of breaking down biofilm. These herbs specifically address the problem of bio-film. The Chinese have used this approach for eons: use a worm to address another “worm” in you body, an almost homeopathic principle.

Finally, there are the herbs with a direct anti-parasitic effect, lead by Qinghao. There are lots of other anti-Gu and anti-malarial herbs in this category. Some are well known like Xuanshen (Scrofularia) and Tufuling (Smilax). Others are completely forgotten like Xuchangxing (Cynanchum) and Guijianyu (Euonymus alatus). In Chinese, the latter’s name literally means “the arrow that kills demons.” There is a long list of herbs in this category, and it is from here that most Western Lyme prescriptions are culled.

The next important category consists of herbs that stabilize the immune system to treat and prevent autoimmune complications. Spirochetes are recognized by our immune system as a particularly tricky invader; consequently, it often goes into overdrive in response to the presence of these pathogens. Among the Chinese organ networks, it is the Spleen that is most often implicated in autoimmune processes.

Some Chinese medicine texts, therefore, describe the Spleen as “the mother of all wind.” On the Chinese organ clock, for instance, the Spleen is located in the position of the 4th lunar month, which used to be called the “wind corner” of the zodiac. It is important to point out that herbs affecting the Spleen were not exclusively thought of as qi tonics such as ginseng and astragalus. Ancient texts also relate certain herbs that clear wind and blood heat to the Spleen. Three herbs that I find particularly important in this context are the classic food items Wanggua (Snake gourd), Jicai (Shepherd’s purse) and Kucai (Hare’s lettuce). These herbs are never used as ingredients in Chinese herbal formulas anymore, but I find them exceedingly useful and have begun to import them as part of the Classical Pearl powdered extract series, as well.

The last, and perhaps most important, category in this anti-Lyme material medica is composed of warming and strongly anti-parasitic herbs from the aconite family. During the last three years, when I synthesized the knowledge transmitted in the classic Gu texts into a general approach to Lyme, I concluded that the use of aconite is indispensible for most Brain Gu patients, especially in the middle and later stages of treatment. I have found different varietals of aconite to be integral elements of a long-term treatment plan for Lyme disease and other forms of nervous system inflammation, specifically Fuzi (lateral offshoots of Aconitum carmichaelii root), Chuanwu (taproot root of same plant) and Caowu (Aconitum kusnezoffii).

At the beginning of this discussion, I emphasized how important I believe it is to work WITH the life force rather than against it—recommending, in essence, a sustained support of the body’s yang qi. The brighter the body’s alarm lights are turned on—and few pathogens activate emotional and physical symptoms like Lyme spirochetes—the greater the stress and the gradual depletion of the body’s yang forces. At the beginning of therapy, Lyme patients may exhibit superficial signs of heat, such as rapid pulses, rashes, feverish sensations, and nightsweats, yet these most often mask an underlying condition of coldness and exhaustion. Once these symptoms disappear with the moderate to slightly cooling approach outlined in the design of Lightning Pearls, Thunder Pearls, Ease Pearls, and Dragon Pearls, the more the body will be comforted by the use of formulas that warm the yang and consolidate the body’s mingmen (gate of life) “battery.”

“When designing a custom Brain Gu formula, I typically use 12-15 herbs, with an average of 1-3 herbs from each of these categories. I find it important to consistently rotate at least one herb in each category every 4-6 weeks. In this way, you can stay ahead of the adaptive ability of the parasite, and avoid triggering allergic responses from your own body. This procedure can include minor changes, such as changing Guizhi to Rougui, or Fuzi to Chuanwu within a category; or medium changes, which involve changing at least one herb in each category; or major changes, which result in a change of the entire base formula.

Dosages vary: generally, I use between 12-18g of powder extracts per day (equivalent to 60-90g of decocted crude herbs per day), but in certain cases of extreme sensitivity I start with a much smaller dosage (2-6g per day), otherwise the super-sensitive types may be overwhelmed by so-called Herxheimer reactions—a common phenomenon in Lyme patients, when the spirochetes are still strong enough to react to a newly introduced treatment.”

 

Anti-lyme wind dispelling herbs:

  • Jinyinhua (Lonicera)
  • Lianqiao (Forsythia)
  • Baizhi (Angelica dahurica)
  • Zisu (Perilla)
  • Gaoben (Ligusticum sinense root)
  • Chaihu (Bupleurum)
  • Guizhi (Cinnamon twig)

 

Biofilm destroying herbs:

  • Sanleng (Scirpus)
  • Ezhu (Zedoaria)
  • Yujin (Curcuma)
  • Zelan (Lycopus)
  • Huajiao (Zanthoxylum)
  • Dilong (Lumbricus)

 

Anti-parasitic herbs:

  • Qinghao (Artemisia annua)
  • Guanzhong (Dryopteris)
  • Huzhang (Polygonum cuspidatum)
  • Guijianyu (Euonymus alatus)
  • Xuchangqing (Cynanchum)
  • Changshan (Dichroa)
  • Miwu (Ligusticum wallichii leaf)
  • Dasuan (Garlic)

 

Anti-lyme blood tonics:

  • Danggui (Angelica sinensis)
  • Chuanxiong (Ligusticum wallichii root)

 

Anti-lyme yin tonics:

  • Baihe (Lily)
  • Heshouwu (Polygonum)
  • Huangjing (Polygonatum root)
  • (Bei) Shashen (Glehnia)

 

Auto-immune:

  • Wanggua (Snake gourd)
  • Jicai (Shephard’s purse)
  • Kucai (Hare’s lettuce)
  • Huangqi (Astragalus)

 

Calming herbs (for adrenal stress, mental/emotional symptoms):

  • Danshen (Salvia)
  • Suanzaoren (Zizyphus)
  • Yejiaoteng (Polygonum stem)
  • Hehuanpi (Albizzia bark)
  • Shichangpu (Acorus)

 

Warm yang, draw life energy back into the battery:

  • Fuzi (Aconitum carmichaeli, lateral root offshoots)
  • Chuanwu (Aconitum carmichaeli, mother root)
  • Caowu (Aconitum kusnezoffi)
  • Rougui (Cinnamon bark)
  • Ganjiang (Ginger, dried)
  • Paojiang (Ginger, roasted)
  • Shengjiang (Ginger, fresh)
  • Wuzhuyu (Evodia)

 

Body pain:

  • Wujiapi (Acanthopanax)
  • Xuduan (Dipsacus)
  • Shenjincao (Lycopodium)

 

 

NOTE: In an earlier article, Fruehauf gave the following categories

Herbs that Scatter Toxins (San Du):

  • Zi Su Ye
  • Bai Zhi
  • Bo He
  • Gao Ben
  • Sheng Ma
  • Ju Hua
  • Lian Qiao

Qi and Blood Tonics with Anti-Gu Natures:

  • Dang Gui
  • Bai Shao
  • He Shou Wu
  • Huang Qi
  • Gan Cao
  • Wu Jia Pi

Herbs that Calm the Spirit (An Shen):

  • Huang Jing
  • Bai He
  • Sha Shen
  • Sheng Di
  • Xi Yang Shen
  • Fu Shen
  • Jiang Xiang
  • Xuan Shen

Herbs that Kill Worms or Parasites (Sha Chong):

  • Yu Jin
  • Ku Shen
  • She Chuang Zi
  • Shi Chang Pu
  • Jin Yin Hua
  • He Zi
  • Lei Wan
  • Qing Hao
  • Da Suan
  • Bing Lang
  • Ku Gua
  • Ding Xiang
  • Huai Hua
  • Chuan Shan Jia

Herbs that Move the Qi and Break Accumulation (Xing Qi and Po Ji):

  • Chuan Xiong
  • Chai Hu
  • E Zhu
  • San Leng
  • Chen Pi
  • Ze Lan
  • Mu Xiang
  • San Qi

 

Additional Notes

  • Fruehauf says Ren shen and Dang shen can exacerbate gu. If someone takes it and feels worse, they have advanced gu usually.
  • Releasing the ext by “fumigating” the body – done for 6-12 mos. with herbs such as Gao ben, Bo he, Zi su ye, Bai zhi
  • Favorite herb: Bai he.  No side effects, kills parasites.
  • Favorite qi tonic for all gu, specifcally when any kind of joint pain is present: Wu jia pi.
  • Most cancer and chronic disease cases and any viral/spirochete/etc are Gu.
  • Gu often implicated in complex presentations. Gu cases don’t have a clear pattern.

Luo Bu Ma – Apocynum leaf – Dogbane

Nature: sweet, bitter, cool

Enters: Liver

Actions: Calms the liver and subdues yang; clears heat and promotes urination; nourishes the heart and quiets the spirit. Lowers blood pressure.

Indications:
• Liver yang rising: dizziness, hypertension, etc.
• Drunk by older people in China as a general health tonic to prevent the problems of aging.
Flaws: Luo Bu Ma (Herba Apocyni Veneti) may be unknown to many students and younger practitioners of Chinese medicine. In part, this is because it is not found in most entry-level Chinese materia medica, nor is it found any major traditional Chinese formulas. However, I think it is a good medicinal to know about. It is included in Bensky et al.’s Chinese Herbal Medicine: Materia Medica, 3rd edition (pages 976-977). In that book, Luo Bu Ma is categorized as a wind-extinguishing medicinal (xi feng yao). According to Bensky et al., it is sweet, bitter, and cool and enters the liver. (Other Chinese sources say this medicinal is bland and astringent. Such differences of opinion are common for relatively “new” Chinese medicinals). Luo Bu Ma levels or calms the liver and subdues yang, clears heat and promotes urination, and nourishes the heart and quiets the spirit (although I’m not convinced about these last functions; more to say about that below).

Luo Bu Ma was, up until recently, a folk medicinal mostly found and drunk as a healthy beverage tea in Inner Mongolia. However, recently, this medicinal has been found to lower blood pressure, lower bad cholesterol at the same time as raising high density (good) cholesterol, reduce edema due either to kidney or heart dysfunction, enhance immunity, and promote longevity. Therefore, this herb is now often drunk both preventively and remedially by the middle-aged and elderly in China and Japan. (The first anti-aging research I can find on this medicinal published in China dates from 1990.)

Research on Luo Bu Ma has been conducted in China, Korea, Japan, and several Western countries. This research shows that this medicinal definitely lowers blood pressure (by increasing nitric oxide and thus vasodilation) and has diuretic, cardiotonic, and antioxidant activity. Other research indicates that Luo Bu Ma has antidepressant potential and can reduce anxiety (in mice, equal to benzodiazapines). Yet other research shows that this medicinal is effective for hypercholesteremia and the prevention of atherosclerosis. A water infusion of this herb has been shown to be hepatoproctective in mice. As if that weren’t enough, Luo Bu Ma can reduce the formation of advanced glycation endproducts which are largely involved in the pathogenesis of diabetic vascular complications. Chinese research suggests that the active ingredients in Luo Bu Ma mainly consist of rutin, d-catechin, and quercetin. However, Japanese research shows that Luo Bu Ma contains more than 15 kinds of phenolic constituents.

The root of this plant contains cardioglycosides and is, therefore, potentially toxic. The leaves, however, do not contain the same cardioglycosides or at least contain much fewer of them. Thus the leaves are considered safe to use even long-term. In fact, Zhang Yun-ru says that its leaves are non-toxic (Bensky, p. 977).

As for Luo Bu Ma nourishing the heart and quieting the spirit, because this medicinal is antidepressant and anxiolytic, it is tempting to make that assumption. However, not all Chinese sources on this medicinal include this function, and I believe it is a species of “over-diagnosis.” The fact that Luo Bu Ma clears heat from the liver appears to be unanimous in the Chinese language Chinese medical literature, and heat ascending (mainly from the liver) to harass the heart is one of the three main proximate causes of the heart spirit stirring frenetically. By clearing this heat, the heart spirit is automatically quieted. However, this does not mean that the medicinal should be thought of a heart-nourishing, spirit-quieting medicinal. In Chinese medicine, there are two kinds of spirit-quieting medicinals: 1) those that nourish the heart and quiet the spirit and 2) those that heavily settle and quiet the heart. Heart-nourishing spirit-quieters tend to nourish and enrich heart blood and yin, and I see nothing in any descriptions of this medicinal that suggest it nourishes yin-blood. I think all this medicinal’s empirical effects can be encompassed by the functions of clearing heat, extinguishing wind, and promoting urination.

This medicinal is included in several Chinese ready-made or so-called patent medicines for hypertension. However, you might consider adding it to other standard formulas based on pattern discrimination when the major complaint is high blood pressure and liver heat, liver yang, or liver wind are playing a part in the overall disease mechanisms. It may also be drunk as a tea (infusion) as a daily beverage in the middle-aged and elderly who, by nature, tend to suffer from a surplus in the liver.

Examine.com:

This plant has similar bioactives to Hypericum perforatum [St. John’s Wort] and while drug-drug interaction tests have not yet shown adverse interactions it is highly plausible that they exist.

At this moment in time there is no optimal dose known for humans, although most of the benefits associated with this plant occur in the rat dosing range of around 25-100 mg/kg and with the water extract of the leaves (ie. the tea). This assumes an estimate human dose of:

  • 270-1,100 mg for a 150lb person
  • 360-1,400 mg for a 200lb person
  • 450-1,800 mg for a 250lb person

These doses are well within the range one would use the leaves to make tea from, suggesting that the food product is active and supplementation may not be needed.

1. Sources and Composition

1.1. Sources

Apocynum venetum (of the family Apocynaceae) is a Traditional Chinese Medicine commonly referred to as Chinese dogbane which has traditional usage for its blood pressure reducing properties secondary to diuresis.[1] Beyond the cardiovascular benefits, it has traditionally been touted to promote longevity[2] and treat both nephritis and neurasthenia[3] but more recently is associated with claims of blood pressure reduction and sedation (which opposes the stimulatory effect of green tea from camellia sinensis due to the Caffeine content).[4] At times medicinal usage of this plant is seen as interchangeable with poacynum pictum and poacynum hendersonii (of the same Apocynaceae family) due to their visual similarity;[4] they can be distinguished genetically[5] or by the hyperoside content.[6]

It should not be confused with the related plant Apocynum cannabinum (Indian Hemp) nor the related plant Apocynum androsaemifolium, both of which have traditional usage for heart health due to their Cymarin content which is therapeutic at low doses but toxic at higher doses; apocynum venetum does have a cymarin content as well (113?g/g in the leaves)[7] which is regarded as safe[4] although the higher levels in the aged stem (1,310?g/g) may not be.

The leaves are sometimes called ‘Luobuma’ (China) or ‘Rafuma’ (Japan), and Luobuma tea refers to the water extract of the leaves.[8][1] The plant itself is a small herbaceous shrub 1-2 meters tall with purplish red to pink flowers, and bears fruits in autumn 7-8 months after flowering.[4] The apocynum venetum shrub is surprisingly resistant to drought and stress (sand, winds, and salt), which may underlies its name of “Herbal for Relief of Famines” (Jiu-Huang-Ben-Cao from the Ming Dynasty).[4]

Apocynum venetum is a small shrub which bears leaves (Luobuma) that are commonly drunk as a tea in order to reduce blood pressure and are claimed to have an added relaxing effect (somewhat opposite of a similar tasting tea, green tea from camellia sinensis); the usage of Luobuma parallels that of Roselle

1.2. Composition

Luobuma (leaves unless otherwise specified) contains:

  • Apocynin A-D (very confusing as this is not the apocynin phenolic (acetovallinone) found in other plants)[9][4]
  • Cymarin at 113?g/g in the leaves, lower levels than Apocynum cannabidum[7] although there are higher levels in the stem (367?g/g) and aged stem (1,310?g/g) as well as the root (195?g/g)[7]
  • Apocyanisode I and II (Ionone glucosides)[10]
  • (+/-)Gallocatechin and (+/-)Catechin[11]
  • (-/-)Epigallocatechin and (-)-Epicatechin[11]
  • (-/-)Epicatechin-()Gallocatechin and Epigallocatechin-()Epicatechin[11]
  • Quercetin[12][13] and related structures such as hyperoside (Quercetin 3-Galactoside) and isoquercitrin (Quercetin 3-Glucoside);[3] said to be in comparable levels to that of Hypericum perforatum;[14] also contains Baimaside (Quercetin 3-O-Sophoroside),[13] Avicularoside (Quercetin-3-Arabinoside)[15] Rutin (Quercetin 3-Rutinoside),[15] and Quercitronic Acid/Querciturone (Quercetin-3-Rhamnoside)[15]
  • Kaempferol[16] and its 3-O-?-D-glucoside (Astragalin),[15][13] Trifolin (Kaempferol 3-Galactoside),[15]
  • Apigenin biflavonoids including Amentoflavone and Biapigenin[15]
  • Hyperforin and Adhyperforin;[15] once novel constituents of Hypericum perforatum
  • Procyanidin B2[11]
  • Cinchonain Ia[17]
  • Caffeic acid and 3-O-caffeoylquinic acid[18]
  • Vanillic acid[13] and Chlorogenic Acid[16]
  • Daucosterol[13] and both Lupeol and Phytol in roasted leaves[10]

The overall content of flavonoids is known to heavily rely on growing conditions.[12]

There is a total amino acid content ranging from 81.76-83.25mg/g (leaf equivalent) but a free amino acid content of 3.85-4.04mg/g, with the most abundant amino acid being glutamic acid (9.82-10.01mg/g total amino acid and 0.29-0.31mg/g free) which was said to confer the Umami taste of the tea.[19]

The leaves of this plant appear to be high in flavonoids, mostly some catechins (some novel and some in green tea) and a large amount of quercetin variants. There also seems to be a lot of parallels in these constituents and those seen in St.John’s Wort surprisingly, since the plants are not phylogenetically related

2. Molecular Targets

2.1. Ion Channels

Apocynum venetum, in cultured N2A neuroblastoma cells at a concentration of 20µg/mL, has been demonstrated to inhibit steady state sodium channels independent of nitric oxide and with an IC50 of 18.4?g/mL; it was readily reversed with washout and voltage gated sodium channels were unaffected.[20]

There was a mild inhibitory effect on voltage gated potassium channels (16.2+/-3.7% and 48.0+/-2.9% inhibition at 10 and 30?g/mL) yet none on ATP-sensitive channels.[20] These effects were lost in the presence of diazoxide, a potassium channel opener.[20]

The leaf extract of apocynum venetum appears to cause mild inhibitory effects on both potassium and sodium channels at a concentration where blood pressure reduction in noted; this is not dependent on nitric oxide formation

3. Pharmacology

3.1. Phase I Enzyme Interactions

Apocynum venetum has similar bioactives to Hypericum perforatum, raising concerns of possible drug interactions.

When fed to rats at 3.3mg/kg, Apocynum venetum leaf extract failed to alter the pharmacokinetics of nifedipine while 33mg/kg and 15mg/kg St. John’s Wort both trended to reduce plasma concentrations over the next 30 minutes.[21] Two weeks treatment of 15mg/kg managed to reduce the AUC of nifedipine while 3.3mg/kg apocynum venetum was ineffective.[21]

May not influence CYP3A activity, although the above study did not test higher (and more practical) doses over two weeks despite trends towards inhibition being present

3.2. Drug Interactions

Apocynum venetum at 3.3mg/kg over two weeks to rats has failed to alter the intestinal permeation of methylprednisone, suggesting no significant influence on the P-glycoprotein transporter.[21]

No significant influence known with P-glycoprotein transporters

4. Neurology

4.1. GABAergic Neurotransmission

The anxiolytic properties of the leaf extract (100-125mg/kg in mice) doses is fully mediated by the GABAA receptor, while lower doses (22.5-30mg/kg) are not; this is thought to be due to Kaempferol which is active at 0.02-1mg/kg oral intake.[16]

Higher doses of this herb appear to have anxiety reducing properties secondary to the kaempferol content acting on the benzodiazepine receptors

4.2. Adrenergic Neurotransmission

A water extract of the leaves for 2-8 weeks in rats noted decreases in noradrenaline at 15-60mg/kg (but not 250mg/kg) in the hypothalamus (8 weeks) and striatum (starting at 2 weeks) by 33-44% in the hypothalamus and 22-39% in the striatum; there was no time nor dose dependence noted.[3] The decline in noradrenaline and its metabolite (homovanillic acid) during depression, however, are fully preserved with 10 days supplementation of 50-100mg/kg (but not 25mg/kg) in mice.[22]

While there may be a small suppressive effect on noradrenaline concentrations at rest, the decline seen during depression is greatly attenuated; this suggests a modulatory effect

Adrenergic receptor density does not appear affected.[3]

No known interactions with adrenergic signalling beyond modifying noradrenaline levels

4.3. Dopaminergic Neurotransmission

L-Tyrosine concentrations in all brain organs does not appear affected with oral ingestion of 15-250mg/kg of the leaf extracts for 8 weeks in otherwise normal rats.[3]

A water extract of the leaves at 15mg/kg daily for eight weeks was able to slightly reduce dopamine concentrations in the hypothalamus (20%); there was no influence of higher doses (60-250mg/kg) nor lower time frames (2 weeks) and these effects were exclusive to the hypothalamus.[3] Elsewhere, 50-100mg/kg (but not 25mg/kg) in mice for 10 days preserved the decrease in dopamine concentrations seen in depression.[22]

DOPAC was slightly reduced when dopamine or noradrenaline were increased[3] but is significantly preserved in states of depression (when dopamine is also preserved.[22] Furthermore, the antidepressant effects of 50-100mg/kg of the extract over 10 days in mice appears to be blocked by both D1 receptor antagonists and D2 receptor antagonists.[22]

Similar to the effects seen with adrenergic signalling, there appears to be little to no effects on dopamine at rest or a small decline in dopamine levels are seen. In states of depression where dopamine would normally be reduced, however, there is a significant preservation of dopamine levels

4.4. Serotonergic Neurotransmission

15-250mg/kg of the leaf water extract for up to 8 weeks in rats does not influence concentrations of serotonin, L-tryptophan, or 5-HIAA.[3] In depressed mice, 25-100mg/kg of the extract has failed to preserve the reduction in serotonin seen in depression.[22]

Unlike the influence on catecholamines (dopamine and noradrenaline), the reduction in serotonin seen with depression is not prevented

The lower anxiolytic dose of the leaf extract (22.5-30mg/kg in mice) appears to be mediated by the 5-HT1A receptors, while higher (100-125mg/kg) doses are not.[16]

There may still be some serotonergic signalling when it comes to very low doses of this plant and possible reductions in anxiety, although more practical higher doses do not appear to be assocaited with serotonin signalling at all

4.5. Alertness

In a rat antidepressant test there did not appear to be any alterations in locomotion nor defecation (thus, no amphetamine like activity is thought to exist).[14] In anxiolytic tests (testing for sedation from benzodiazepine like effects) the leaf extract was not significantly different from 1.5mg/kg diazepam at the active doses (22.5-30mg/kg) in altering motor function[23] nor was the active GABAergic agent Kaempferol (0.02-0.08mg/kg).[16]

Does not appear to have any significant sedating properties (assessed by locomotor tests) nor amphetamine-like properties when tested in rodents

4.6. Neuroprotection

Mechanistically, hyperoside at 2.5-10?g/mL appears to attenuate the increase in intracellular calcium (PC12 cells) induced by corticosterone (10?M) with a protective effect comparable to 10?M fluoxetine[24] and thought to be secondary to this there was a preservation of BDNF and CREB activity (greater than fluoxetine but not normalized to control)[24] associated with a relative preservation of BDNF and MAP4 mRNA levels.[25]

In the presence of hyperoside, the neurodegenerative effects of corticosterone are attenuated and the antidepressive factors (BDNF, CREB, MAP4) are preserved somewhat

Elsewhere, in vitro with PC12 cells treated with 1-10?g/mL of the herbal extract apocynum venetum appeared to reduce lipid peroxidation to a greater extent than both Ginkgo biloba and St.John’s wort, although 100?g/mL of the extracts were comparable.[26]

In an in vitro test of oxygen and glucose deprivation (test of benefits against ischemia-reperfusion), 5-50?g/mL of apocynum venetum showed mild protective effects not exceeding 50% cell viability (control at 100% and oxygen deprivation near 30%);[27] higher concentrations (5-500mg/mL) were not significantly better.[27]

500mg/kg of the extract in rats prior to ischemia has been noted to improve the neurological score when measured 24-72 hours after ischemia (250mg/kg only active after 72 hours and 125mg/kg ineffective) and was able to half infarct size relative to control.[28] Alongside the reduced infarct size was reduced edema and brain leakage, which appeared to be associated with preservation of the blood brain barrier’s structure (and reductions of both MMP2/9 and lipid peroxidation).[28]

Shows some promise against lipid peroxidation and oxidative stressors, and while the potency against oxygen deprivation seems to be less it is relevant in rat models of ischemia where there are minor anti-stroke properties

4.7. Depression

30-125mg/kg of the leaf water extract of apocynum venetum appeared to possess antidepressant effects in the forced swim test with a potency comparable to 20mg/kg Imipramine.[14] Higher doses of the extract (250-500mg/kg) were ineffective initially but performed equally after two weeks[14] and 50-100mg/kg of the extract, but not 25mg/kg, has elsewhere been effective in the tail suspension test (more than 5mg/kg fluoxetine) while all doses were comparable to fluoxetine in a forced swim test[22] and prevented with dopamine receptor antagonists (D1 and D2).[22]

There appears to be a somewhat respectable antidepressive effect associated with catecholamine metabolism, probably secondary to preventing their decline during stress

4.8. Anxiety

In an elevated maze plus test, mice given 22.5–30mg/kg and 100–125mg/kg of the leaf extract (standardized to 3.5% hyperoside and 3.2% isoquercitrin) experience a reduction in anxiety with the lower dose being more potent (to a comparable level as 1.5mg/kg diazepam and 10mg/kg buspirone).[23][16] The lower dose hindered by 5-HT1A receptor antagonists while the higher dose was fully blocked by benzodiazepine receptor antagonists.[16]

There are anti-anxiety effects associated with the tea, but unlike the antidepressive properties (associated with catecholamines) these seem to be related to GABA and serotonin signalling; it occurs at lower doses than antidepressive effects

5. Cardiovascular Health

5.1. Cardiac Tissue

In isolated atria cells (guinea pig), apocynum venetum causes a cardiotonic effect at 1mg/mL (little to no response at 100µg/mL) yet this was not correlated with the cymarin content of the plant (cymarin being a known cardiac glycoside in this plant species) nor was it blocked by propanolol;[7] it appears that components of apocynum venetum have PDE3 inhibiting properties, with 1mg/mL of the leaf, root, and stem extracts inhibiting 84-88% of PDE3 activity.[7]

Preliminary evidence suggests a cardiotonic effect, but practical relevance is unknown (and a high concentration used in the heart, which may not apply to oral supplementation)

5.2. Blood Pressure

While the water extract of the leaves (0.1–10µg/mL) does not influence endothelial function in vitro at rest nor is it active in denuded cells, it appears to concentration dependently inhibit phenylephedrine and U46619 (Thromboxane A2 receptor agonist) in a manner fully dependent on NOS enyzmes.[1] There is no relaxing effect against endothelium precontracted with potassium, but the effect persisted after two washes of the cells.[1] The mechanisms are known to involve potassium channels[29][1] although it is not clear how, although some authors[1] have noted the atypical mechanisms are similar to both Eucommia ulmoides[30] and Eleutherococcus senticosus[31] and apocynum venetum has elsewhere been noted to have mild inhibitory effects on voltage gated but not ATP sensitive potassium channels (not mediated by nitric oxide).[20]

0.3-10?g/mL apocynum venetum appears to suppress the aortic contractions induced by ACE (Angiotension II),[32] the peptide of which its inhibition is the current blood pressure reducing therapy. This is thought to be due to inhibiting ACE induced superoxide production (ACE, via acting on the AT1 receptor, increases NADPH oxidase and O production[33][34] which suppresses nitric oxide[35]) and induction of nitric oxide synthesis.[32] Furthermore, the reaction of superoxide and nitric oxide is known to produce peroxynitrite (ONOO) which can negatively regulate NOS enzymes[36] and apocynum venetum directly sequesters these peroxynitrite radicals via its catechins;[37] sequestering ONOO is known to block its suppressive effects.[36]

Apocynum venetum appears to have blood pressure reducing mechanisms that are within a feasible concentration range, and while the mechanisms are not fully elucidated they appear to be related to nitric oxide signalling, antioxidant effects, and calcium channels

In hypertensive rat models (spontaneously, renal, and salt fed) given 70mg of the water leaf extract of apocynum venetum daily (333-350mg/kg) for 40-100 days, the tea was able to reduce blood pressure in all three rat models more than control and while equally potent to 30mg/kg Captopril in one model (renal hypertensive) it underperformed in the other two.[8]

In the sodium fed rats, urine output was increased with apocynum venetum (2.1 and 2.6 fold on days 20-60) which did not occur with the roasted leaves;[8] there were no differences in the magnitude of blood pressure reduction between groups, and increased urination occurred in both groups of the renal hypertensive rats.

Blood pressure reduction has been noted with ingestion of the water extract of the leaves, and this appears to occur to a lower degree than the reference drug but up to two-fold higher doses than the antidepressant effects

5.3. Atherosclerosis

In vitro, LDL oxidation from copper is reduced by 10-100µg/mL of apocynum venetum extract with the higher dose preventing any significant differences from nonoxidized control[38] and an IC50 value of 68.1µg/mL being determined for the leaf extract (mostly due to chlorogenic acid and epigallocatechin, with IC50 values of 1.9µM and 2.3µM respectively).[17]

This potent inhibition of LDL oxidation was met with only 39% inhibition of lipid peroxidation (TBARS) and halved the increase in macrophage cholesterol accumulation when LDL and macrophages were in the same culture with copper[38] (to assess foam cell formation, involved in the pathology of atherosclerosis). Elsewhere, TBARS from LDL oxidation was reduced in a concentration dependent manner between 2.5-200µg/mL (9.8-88.3%) with most inhibitory effects coming from hyperoside, chlorogenic acid, and epigallocatechin.[17]

May reduce LDL oxidation due to its antioxidant properties, but practical relevance of this information is not known. Possible anti-atherosclerotic properties and reducing plaque formation on arties

6. Interactions with Glucose Metabolism

6.1. Glycation

When investigating the formation of advanced glycemic end products (AGEs) the water extract appeared to inhibit AGE formation with an IC50 value of 37.2+/-0.6µg/mL, which outperformed the reference drug of Aminoguanidine (59.2+/-1.5µg/mL).[11] This may be related to the known catechins, which had IC50 values between 19.8+/-0.8µg/mL (Gallocatechin) and 9.1+/-0.2µg/mL (Epigallocatechin).[11]

Possible antiglycative properties, which would reduce AGE formation and may be of use for diabetes or insulin resistance (reducing organ damage, rather than treating the state)

7. Interactions with Oxidation

7.1. Lipid Peroxidation

The aqueous leaf extract at 10mg/kg given to rats after liver damage (from CCl4) failed to significantly reduce serum MDA levels relative to control, although it trended towards such[39] and appeared to have antioxidative properties against H2O2 and iron in vitro in the range of 15-1,000µg/mL.[39]

8. Interactions with Organ Systems

8.1. Kidneys

Chronic (20-60 days) ingestion of a nonroasted water extract of apocynum venetum leaves in rats at 335-350mg/kg appears to increase urine output of rats on a high sodium diet (2.1-fold and 2.6-fold on days 20 and 60); this effect was not noted with twice roasted leave.[8] Oddly, diuresis was increased by both the roasted and unroasted leaves in rats with hypertension secondary to renal damage.[8]

Appears to be a diuretic at the doses which reduce blood pressure

9. Safety and Toxicology

9.1. General

The LD50 of apocynus venetum appears to be greater than 10g/kg in rats and preliminary genotoxic and teratogenic studies have failed to find any harm associated with the plant,[4] and later a 30 day test failed to find any abnormalities up to 30g/kg in mice[40] and in continuing the in vitro studies a lack of genotoxicity was repeated and no abnormalities in sperm cells were noted.[40]

Preliminary evidence in rodents does not suggest any toxic effects from this plant even at abnormally high oral doses

 

Dose: 3-9g

Liu Huang – Sulfur – “Sulfur Yellow”

Nature: sour, toxic, warm

Enters: Kidney, Large Intestine

Topical Actions: Kills parasites; eases itching; relieves toxicity.

Topical Indications:

• Scabies, eczema, ringworm, Yin furuncles, damp festering sores, ulcers, carbuncles, itching, acne.
• Used as powder or paste. Also available in soap form (e.g., Thylox) for acne.
Hong-Yen Hsu (Oriental Materia Medica): Dissolves corneous skin, can cause hair to fall out.

Internal Actions:  Tonifies kidney Yang (strengthens Ming Men fire); promotes bowel movement.

Internal Indications:

• Yang deficiency, internal cold: asthma, impotence, painful lower back and knees
• Cold: constipation, especially in the elderly (works by helping the Yang to pass the stool and also by irritating the wall of the gut by forming sulfides – more pronounced effect when there is an abundance of fatty substances in the gut).
Hong-Yen Hsu (Oriental Materia Medica): Antifungal, purgative.

Internal Dose: 1-6g (pills and powders)

Lu Feng Fang – Hornet Nest

Nature: sweet, toxic, neutral

Enters: Lung, Stomach

Topical Actions: Relieves toxicity, expels wind, alleviates pain.

Topical Indications:

• As an ointment or wash for rashes, itching, scabies, ringworm, sores, carbuncles, swollen glands.
• As a gargle: use warm for a severe toothache that feels “as if a worm is burrowing in the tooth.”

 
Internal Actions:  Expels wind, dries dampness.

Internal Indications:

• Wind-damp Bi.
• Wind rashes.
• Recent use in the treatment of a variety of tumors.
• Shortens blood coagulation time.
• Mastitis: In one study, 3g of dry-fried Lu feng fang was given with wine every 4 hours for 3 days. 23 of 26 cases were cured (in an average of 2 days) and 1 was improved. No side effects or toxic effects were noted. This form of therapy is not effective for suppurative mastitis.
• Toxic: large doses cause nephritis.

Internal Dose: 6-12g (1.5-3g directly as powder)

Ma Qian Zi – Strychnos nux-vomica seeds – Nux-vomica – “Horse Money Seeds”

Nature: bitter, cold, very toxic

Enters: Liver, Spleen

Actions:  Unblocks the channels, disperses clumps, reduces swelling, alleviates pain.

Indications:
• Internal or external for abscesses, sores, yin-type ulcers, and swelling and pain due to trauma.
• Wind-damp Bi, paresthesias, spasms.
• Recently used in the treatment of various types of tumors.
• Facial paralysis: the herb was applied locally as a paste in over 15,000 cases, with effective results in 80% of the cases.
• Contains strychnine. Overdoses in humans have been recorded with as little as 50 mg of the herb. Overdosage presents with a crawling sensation in the cervical area, difficulty in swallowing, and irritability. The progresses to convulsions of great force.
• Used externally in powders for local application, including insufflation into the throat.
Rudolf Weiss (Herbal Medicine): In small doses, the herb is a bitter tonic. This herb is the leading nervous system stimulant. Indispensable as a major nerve tonic. The drug of choice when one needs powerful and lasting stimulation of the nervous system. Often used for the elderly, and for pale children lacking an appetite (good with galanga). For nervous stomach conditions, it also reduces sensitivity to pain.
• According to Weiss, this herb is safer than stated. “Really good results are achieved only with relatively large doses: 10-20 drops of the tincture in a glass of water three times daily.”
[Other sources (Potter’s Cyclopaedia of Botanical Drugs and Preparations) are much more cautionary – strychnine can be fatal.]
Hong-Yen Hsu (Oriental Materia Medica): Promotes blood circulation and breathing; can induce muscular tetany; increases intestinal peristalsis.

Dose: 0.3-0.9g internally in pills and powders

Ming Fan – Bai Fan – Alum – Basic Potassium Aluminum Sulfate – also Ku Fan, the prepared form

Nature: sour, cold

Enters: Lung, Liver, Spleen, Stomach, Large Intestine.

Topical Actions: Eliminates toxicity; kills parasites; dries dampness; eases itching; stops bleeding.

Topical Indications:

• As a wash for scabies, ringworm, carbuncles, damp/damp-heat rashes – eczema.
• Bleeding: epistaxis, hemorrhoidal bleeding, bleeding gums, bleeding due to external injury.
• Swollen and painful throat or eyes.
• Ear drops for chronic otitis media.
• For external use, Ku fan (the prepared form) is preferred for sores and abscesses, oral sores, eye problems.

Topical Dose: 15-30g

 
Internal Actions:  Stops bleeding and diarrhea; clears heat and phlegm; dried dampness.

Internal Indications:

• Hematemesis, epistaxis, hemafecia, chronic diarrhea, uterine bleeding, vaginal discharge. Ulcerative colitis.
• Jaundice.
• Wind-phlegm/phlegm-heat: epilepsy, irritability, delirium, depression, mania, cough with difficult-to-expectorate sputum.
• Ming fan has a strong stimulatory effect on the body’s tissues. Overdose can cause ulceration, vomiting, diarrhea, shock.
• The cumulative effect of long term ingestion of aluminum may not be healthy (Alzheimer’s?).
• Crush before using.

Internal Dose: 0.6-3g

Peng Sha – Borax – Sodium Borate / Sodium Tetraborate Decahydrate

Nature: sweet, salty, cool.

Enters: Lung, Stomach.

Topical Actions: Dries dampness, relieves toxicity, prevents putrefaction.

Topical Indications:

• Blisters between toes caused by damp-toxicity.
• Sores, including nasal, pharyngeal, vaginal sores.
• Used internally or externally for pain and swelling in the throat, open sores in the mouth (canker sores), white draining vaginal lesions (e.g. severe candidiasis).

 
Internal Actions: Clears heat; dissolves phlegm; transforms stones, relieves toxicity, prevents putrefaction.

Internal Indications:

• Phlegm-heat obstruction with difficult-to-expectorate sputum.
• Painful urinary dysfunction with stones.
• Used internally or externally for pain and swelling in the throat, open sores in the mouth, white draining vaginal lesions (e.g. severe candidiasis).
• In the Bensky/Clavey/Stoger Materia Medica, this substance is classified as “obsolete,” which the authors claim is due to its toxicity. I have not seen Peng sha referred to as toxic in other resources on Chinese herbs. However, in the Wikipedia entry on borax, its toxicity is discussed at length. Here is an excerpt:
“Borax, sodium tetraborate decahydrate, is not acutely toxic. Its LD50 (median lethal dose) score is tested at 2.66 g/kg in rats: a significant dose of the chemical is needed to cause severe symptoms or death. The lethal dose is not necessarily the same for humans.
“Sufficient exposure to borax dust can cause respiratory and skin irritation. Ingestion may cause gastrointestinal distress including nausea, persistent vomiting, abdominal pain, and diarrhea. Effects on the vascular system and brain include headaches and lethargy, but are less frequent. ‘In severe poisonings, a beefy red skin rash affecting palms, soles, buttocks and scrotum has been described. With severe poisoning, erythematous and exfoliative rash, unconsciousness, respiratory depression, and renal failure.’
“Borax was added to the Substance of Very High Concern (SVHC) candidate list on 16 December 2010. The SVHC candidate list is part of the EU Regulations on the Registration, Evaluation, Authorisation and Restriction of Chemicals 2006 (REACH), and the addition was based on the revised classification of Borax as toxic for reproduction category 1B under the CLP Regulations. Substances and mixtures imported into the EU which contain Borax are now required to be labelled with the warnings “May damage fertility” and “May damage the unborn child”.”

Internal Dose: 1.5-3g

She Chuang Zi – Cnidium seed – “Snake’s Bed Seeds”

Nature: acrid, bitter, warm

Enters: Kidney

Topical Actions: Dries dampness; kills parasites; stops itching.

Topical Indications:

• Dampness: eczema, any itching, weeping skin lesion especially of the external genitalia region.
• Scabies.
• Ringworm.
• Use as a wash, powder, or ointment.

Topical Dose: 15-30g

Internal Actions: Tonifies kidney Yang; disperses wind, cold; dries dampness.

Internal Indications:

• Kidney deficiency or cold womb: impotence, male or female infertility.
• Cold and dampness: leukorrhea, trichomonal vaginitis.
• Dampness (especially wind-cold-damp): lumbar pain.
Hong-Yen Hsu (Oriental Materia Medica): Antifungal; antiviral; anthelmintic; sex-hormone-like action – prolongs sexual intercourse in mice and can induce copulation in castrated mice.
Heiner Fruehauf: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.

Internal Dose: 3-10g

Wa Leng Zi – Ark shell – Cockle shell

Nature: salty, neutral

Enters: Lung, Stomach, Liver

Topical Actions: Regenerates tissue for ulcers.

 
Internal Actions: Resolves phlegm; promotes blood circulation and dispels blood stasis; softens and resolves masses and lumps; neutralizes stomach acid; alleviates pain.

Internal Indications:

• Stagnation of blood, Qi, and/or phlegm: fibroids, cirrhosis of the liver, immobile or mobile abdominal masses.
• Chronic pain in the pit of the stomach (such as ulcer pain) or blood stasis pain accompanied by vomiting with acid reflux.
• Ulcers: In one clinical trial, 124 patients with gastric and duodenal ulcers were treated with a powder of 5 parts Wa leng zi and 1 part Gan cao. Treatment periods ranged from 29 to 56 days. 59 cases were cured and another 48 showed significant improvement.
• The raw herb should be used for promotion of blood circulation and dissolution of phlegm, while the calcined form is preferred for the neutralization of stomach acid, acid reflux (GERD), heartburn.
• Requires precooking. The herb should be broken into pieces or ground into powder before cooking.
• Bensky and Gamble classify this herb as a blood mover. The herb is also commonly classified among herbs that resolve phlegm (a categorization Guohui Liu also agrees with).

Internal Dose: 9-15g

Xiong Huang – Realgar – Arsenic Sulfide – “Male Yellow”

Nature: acrid, bitter, warm, toxic

Enters: Heart, Liver, Stomach

Topical Actions: Eliminates toxicity; kills parasites.

Topical Indications:
• Carbuncles, snake bites, scabies, ringworm, damp rashes, abscesses, suppurative inflammation of the soft tissue, ulcerations.
• Very commonly used in soaks for any skin itching.
• As a paste for neurodermatitis/shingles.
• Because it is absorbed through the skin, the herb should not be applied to large areas.

 
Internal Actions: Kills worms; dries dampness; expels phlegm; checks malarial conditions.

Internal Indications:
• Worm parasitism in the intestines: pain – especially for roundworms, and particularly with signs of accumulation.
• Dampness/phlegm accumulation: wheezing; seizures; malarial conditions.
• Do not calcine. Calcination produces the extremely toxic As2O3.

Internal Dose: 0.15-0.6g in pills and powders

Sang Piao Xiao San

Ingredients: sang piao xiao, long gu, ren shen, fu shen, yuan zhi, shi chang pu, (zhi) gui ban, dang gui

Actions: regulate & tonify Ht & K, stabilize essence, stop leakage

Indications: K & Ht Qi xu: frequent urination, sometimes incontinence, urine the color of rice water, maybe spermatorrhea; also disorientation, forgetfulness, pale tongue, white coat, thin slow frail pulse.

See S. Dharmananda’s “Sang Piao Xiao San – Example of a Mind-Body Formula”

Xue Jie – Dragon’s Blood – Resinous secretion of Daemonoropis draco or Dracaena cambodiana

Nature: sweet, salty, neutral

Enters: Heart, Liver

Topical Actions: Promotes regeneration of tissue; stops bleeding.

Topical Indications:
• Bleeding due to external trauma.
• Non-healing skin ulcers: protects the surface of the ulcer, prevents decay, and generates flesh.
Weng Weiliang, et. al.:
• Ulcer after tumor operation: Xiao Du San: xue jie, feng fang tan, bi hu, 10g each; bing pian 5g, honey of proper amount. The drugs were grounded into fine powder and applied to the ulcer which was surrounded by honey later, then the honey was applied on top of the drug powder. 33 cases of ulcer after tumor operation were treated, and scab formed after 6.5 days averagely.
• Primary liver cancer: Pu Tuo Gao made of xue jie, quan xie, wu gong, shui hong hua zi, bai jiang can, mu bie zi, da feng zi, zhe cong, bing pian was applied externally for 5~7 days. Change the dressing after 3 days’ interval, 12 times as a course of treatment. 67 cases of primary liver cancer were treated, and the pain alleviating rate was 96.7%.
• Bedsore: san qi, xue jie, hong hua, ze lan, dang gui wei, ru xiang, mo yao, zhi ma qian zi, hu po, sheng da huang, tao ren, xu duan, gu sui bu, zhe chong, zi ran tong, su mu, qin jiao, zao xiu. All drugs were soaked in wine for 3~6 months. The infusion could be used to treat bedsore and had swelling relieveing, tissue regenerating effect.

Topical Dose: 6-9g

 

Internal Actions: Promotes blood circulation, dispels blood stasis, alleviates pain.

Internal Indications:
• Blood stasis: trauma, swelling, pain, symptoms related to injury from falls, fractures, contusions, sprains, endometriosis.
• Similar to San qi, but weaker than San qi at promoting blood circulation or stopping bleeding.
• Contraindicated in patients without blood stasis.
• Bensky and Gamble classify this herb as a blood mover.
Eric Brand:
Xue Jie (Daemonoropis Resina) is a fascinating substance. Also known as Dragon’s Blood, Xue Jie has been used for hundreds of years in many different cultural contexts. Xue Jie is a tree resin that has been used as a medicine, incense, and dye since ancient times. It was recorded in Greece by Dioscorides and appeared for the first time in Chinese medicine in the Lei Gong Pao Zhi Lun (Master Lei’s Treatise on Drug Processing), written in the Northern and Southern Dynasties period (420-589 CE). It later appeared in the Tang Ben Cao (Tang Materia Medica), the first Imperial textbook on materia medica.
Xue Jie is used for a diverse range of purposes. In Chinese medicine, it is said to quicken the blood, stanch bleeding, and engender flesh. It is a major medicinal in traumatology and is also used to treat bleeding in the upper GI tract. Beyond injuries and bleeding, if we look at its applications in modern Chinese medical gynecology, we find that Xue Jie is an incredibly important medicinal in empirical formulas to treat endometriosis.
The importance of Xue Jie in endometriosis is evident when examining modern Chinese textbooks on TCM gynecology. Its claim to fame lies in expelling old blood stasis so that new blood can be engendered; in fact, its Chinese name literally means “exhausted (spent) blood.” Looking at the treatments for endometriosis relative to traditional TCM disease categories such as painful menstruation or concretions and conglomerations (zheng jia), we see that the formulas selected for the same patterns are consistent but nearly all the endometriosis formulas add in Xue Jie. Thus, clearly the experts in China know something about Xue Jie that most of us do not.
Xue Jie in the treatment of Endometriosis
Hong-Yen Hsu (Oriental Materia Medica): Antibacterial, hemostatic.

Internal Dose: 0.3-1.5g

Notes on This Category

• These herbs stop bleeding by any of four actions:
1. Cooling the blood
2. Astringing
3. Dispelling blood stasis
4. Warming the channels
• Herbs in this category are commonly combined with:
A. Herbs that tonify the spleen when bleeding is caused by spleen Qi deficiency.
B. Herbs that clear heat and cool the blood when blooding is caused by heat in the blood.
C. Herbs that promote blood circulation when bleeding results from blood stagnation.
D. Herbs that warm the Yang when bleeding is due to Yang deficiency cold.
• Qi should only be strongly tonified (in cases of bleeding) when heavy bleeding has led to Qi collapse.

Other Herbs to Consider for Stopping Bleeding, When Appropriate (most better when charred):
Bai ji li – Tribulus, Chi shi zhi – Clay (halloysite / kaolinite), Chun gen pi – Ailanthus, Da huang – Rhubarb, Dai zhe shi – Hematite, Dong chong xia cao – Cordyceps, E jiao – Ass hide gelatin, Gan jiang – dry Ginger, Gu sui bu – Drynaria, Guan zhong – Dryopteris (or analogs), Gui ban – Turtle shell, Hai piao xiao – Cuttlefish bone, Han lian cao/Mo han lian – Eclipta, Huang lian – Coptis, Huang qin – Scutellaria, Huang yao zi – Dioscorea bulbifera, Jiang huang – Turmeric, Jiang xiang – Dalbergia, Jing jie – Schizonepeta, Lian xin  – Lotus heart, Lu jiao jiao – Deer antler gelatin, Ma bo – Puffball mushroom, Ming fan – Alum, Mu dan pi – Moutan, Mu zei – Equisetum, Qing hao – Artemisia annua, Ren shen – Ginseng, Sang ye – Morus leaf, Shan zhu yu – Cornus berry, Shi liu pi – Pomegranate rind, Shi wei – Pyrossia, Su mu – Sappan, Wu bei zi – Sumac gall, Wu ling zhi – Flying squirrel feces, Wu mei – Mume, Xu duan – Dipsacus, Xue jie – Dragon’s blood resin, Yin chai hu – Stellaria, Zhi zi – Gardenia, Zhu ru – Bamboo.

Ai Ye – Mugwort leaf – Artemisia argyi or A. vulgaris or A. lavandulaefolia

Nature: bitter, acrid, warm

Enters: Liver, Spleen, Kidney

Actions: Stops bleeding; warms the channels; disperses cold, relieves pain; warms the womb; pacifies the fetus

Indications:
• Yang deficiency cold: bleeding, including prolonged menstrual bleeding, uterine bleeding.
• Cold and Yang deficiency of the liver and kidneys: cold and pain in the abdomen, irregular menstruation, dysmenorrhea, leukorrhea, restlessness of the fetus, threatened miscarriage, vaginal bleeding.
• Cold in the womb: infertility.
• Compared to Rou gui: both can alleviate abdominal pain due to cold. Ai ye is most effective when the pain is due to damp-cold. Rou gui is most appropriate for abdominal pain due to cold from deficiency where the extremities are cold, as in Yang deficiency or Yin and Yang deficiency. Also, while Ai ye calms a fetus, Rou gui will stimulate it.
• The fresh, crushed herb can be applied to warts. When used several times a day in one study of 12 patients, warts fell off within 3-10 days.
• Antibiotic (in vitro) against such pathogens as staphylococcus, streptococcus, shigella, and salmonella.
• Malaria: large doses given for two days to malaria patients two hours before onset of symptoms showed control of symptoms in 89% of cases, plus negative blood examinations for the parasite in over half of those cases.
• In its raw form, the herb is relatively neutral and may be used for bleeding due to heat patterns (e.g. heat in the blood) when combined appropriately.
• Char the herb to enhance both its warming and hemostatic properties.
Michael & Leslie Tierra: Ashes from moxibustion are even more effective than the unburnt herb to stop bleeding. They can be effectively applied to the feet for non-healing sores from diabetes.
Kenner & Requena: Emmenagogue, slight tonic, stimulates secretion of pituitary gonadotropins (FSH and LH).
• Wood yin, earth yin, metal yin.
• Wood: stimulates bile secretion, increases appetite, facilitates digestion, abortifacient (not without danger)
• Hypotension, syncope, epilepsy, hypo-estrogenic amenorrhea, functional uterine bleeding, menstrual cramps, neurological and psychiatric syndromes which originate with the liver, dyspepsia.

• Earth: antimicrobial, estrogenic and luteotropic.
• Insufficient menses, amenorrhea, insufficiency of corpus luteum due to anemia.
• In Russia, the herb has been used as sedative for convulsions, epilepsy, neurasthenia, dysmenorrhea, labor pain.
• In Japan, the herb is used in mochi for stamina and by new mothers to stop postpartum blood loss, to treat anemia, and to stimulate lactation.
• Amenorrhea from general causes, especially for women with a wood deficiency or metal deficiency constitution.
• Long reputation as a spring tonic.
Yoga of Herbs (Frawley & Lad): Nagadamani: lowers Vata & Kapha; raises Pitta (in excess)
• Bitter, pungent/heating/pungent.
• Emmenagogue, antispasmodic, hemostatic, diaphoretic, anthelmintic, antiseptic.
• Good for Sama Vata conditions (arthritis, nervous conditions with obstructed Vata).
• Strengthens the fetus; opens and purifies the channels (circulatory and nervous), relieves pain; warms the lower abdomen, fortifies the uterus.
• Good for menstrual cramps, headache.
Potter’s Cyclopaedia of Botanical Drugs and Preparations: Emmenagogue, diaphoretic, choleretic, anthelmintic, diuretic, stomachic, orexigenic.
• Amenorrhea, anorexia, dyspepsia.
• Threadworm, roundworm.
Matt Wood: Good for perimenopausal women.
Hong-Yen Hsu (Oriental Materia Medica): Antifungal.
Culpeper: Mugwort is an herb of the planet Venus. “Its tops, leaves, and flowers are full or virtue; they are aromatic, and most safe and excellent in female disorders. For this purpose the flowers and buds should be put into a teapot and boiling water poured over them, and when just cool, be drunk with a little sugar and milk; this may be repeated twice a day, of oftener, as occasions require. It is boiled among other herbs for drawing down the courses, by sitting over it, and for hastening the delivery, and helps to expel the afterbirth, and is good for the obstructions and inflammations of the mother. It breaks the stone and provokes water. The juice made up with myrrh, and put under as a pessary, works the same effects, and so does the root. Made up with hog’s-grease into an ointment, it takes away wens, hard knots and kernels that grow about the neck, more effectually if some daisies be put with it. the herb itself being fresh, or the juice, is a special remedy upon the over-much taking of opium. The drams of the powder of the dried leaves taken in wine, is a speedy and certain help for the sciatica. A decoction made with camomile and agrimony, and the place bathed therewith while it is warm, takes away the pains of the sinews, and the cramp. The moxa, so famous in eastern countries for curing the gout by burning the part affected, is the down which grows upon the under side of this herb.”
PJE: As this plant is so frequently used as a charm, and is held in a measure of superstitious veneration by the people, it is a little difficult to determine just where its remedial use in native therapeutics begins. At the time of the Dragon Festival (fifth day of the fifth moon) the artemisia is hung up to ward off noxious influences. This is done either together with a Taoist charm, in which case it is called Ai Fu, and is hung at the head of the principal room of the house, or together with the Shi Chang Pu at the door; the leaves of the latter being formed in the shape of a sword (called Pu Chien) and placed over the door, while a stalk of the artemisia is hung on each door post. That this was efficacious in at least one instance is attested by the fact that the famous rebel, Huan Chao, gave orders to his soldiers to spare any family that had artemisia hung up at the door. The moxa is employed by buddhist priests in initiating neophytes; three rows of three, four, or five scars each being burned on the crown of the head with this substance. Many also use the moxa on a 3 day-old, burning one or more scars on the face; this being supposed to insure the child’s living through infancy. The places for burning are yintang, St-1, St-2, or St-3, and GV-26. Place artemisia in the shoes to gain strength during long walks or runs. For this purpose, pick it before sunrise saying …Tollam te artemesia, ne lassus sim in via.
A pillow stuffed with mugwort will produce prophetic dreams. When carrying mugwort, you cannot be harmed by poison, wild beasts, or sunstroke. In a building, mugwort prevents elves and ‘evil thynges’ from entering. Bunches of mugwort are used in Japan by the ainus (who are they?) to exorcise spirits of disease who are thought to hate the odor. Mugwort is carried to increase lust and fertility, to prevent backache, and to cure disease and madness.
Dr. Peter Eschwey: With regard to our tendency to forget about the waking world when we’re dreaming and to forget about the dreaming world when awake, mugwort provides the bridge of memory between the two worlds.
Peter Holmes: Asian mugwort (Artemisia argyi) is not the same botanical species as the Western mugwort, which is Artemisia vulgaris. The latter was once confused with the former. Moreover, the two herbs cannot be substituted across the board. With its astringent, decongestant, and relaxant actions, Asian mugwort leaf is used primarily to stop uterine bleeding, relieve pain, disinfect and relieve cold and Qi constraint conditions of the uterus. Western mugwort herb, conversely, mainly stimulates the uterus and generally disinfects. Like most remedies in this subsection, Asian mugwort leaf can be seen to activate the Dai and Yang Wei extra meridians in its blood decongestant, astringent and hemostatic action on the pelvic/uterine area. This herb, moreover has the distinction of entering the Ren channel. This is suggested by its historical use for dysmenorrhea, irregular cycles and infertility, as well as in its use for asthmatic and eczematous conditions. Two strongly anticomplimentary polysaccharides have been recently found in Asian mugwort leaf, providing theoretical support for its immune stimulating and interferon producing activities. The use of this remedy for a range of type I or immediate allergic conditions is today well documented.
Karen Vaughan, 2-24-01: Mugwort, harvested in late October after flowering rather than in Summer as in TCM, is traditionally used for dream pillows in Western herbalism. It is smoked as a euphoriant (for which lesser quality with high stem content is best and the effect is stronger with repeated use). A teaspoon or two is eaten to induce sleep.

Dose: 3-9g

Bai Ji – Bletilla rhizome

Nature: bitter, sweet, astringent, slightly cold

Enters: Lung, Liver, Stomach

Actions: Relieves swelling; promotes tissue regeneration; stops bleeding by astringing.

• Mainly used for bleeding from the Lungs or stomach: hemoptysis, hematemesis, epistaxis.
• Heat and toxicity: carbuncles, cracks on hands and feet; also sores, ulcers, chapped skin. Reduces the swelling of sores, helps speed resolution of ulcers. Especially useful for chronic, non-healing ulcers. For these indications, and for bleeding from traumatic injury, it is usually applied topically.
• Pulmonary tuberculosis: in 60 chronic cases which had not responded to normal therapy, 42 were clinically cured and 13 were significantly improved after taking Bai ji for three months. Also successful in bronchiectasis.
• Useful as a powder for stopping bleeding in surgery.
• Bleeding ulcers, carefully selected cases of gastric or duodenal perforation: Stopped bleeding in all 69 cases of bleeding ulcers in one study. Successful in 23 of 29 cases of perforated ulcers in another study. Contraindicated for patients who (1) do not have a definite diagnosis; (2) have recently eaten; (3) the physical exam reveals marked abdominal distention, reduced bowel sounds, or a painful rectal examination; or (4) are in unstable condition for any reason. Some clinicians feel Bai ji should not be used for perforation for the following reasons: (1) the powdered herb can increase peristalsis and therefore enlarge the perforation; (2) the above, together with an increase in nausea and vomiting, can increase leakage into the abdominal cavity; and (3) because powdered Bai ji is adhesive, it can cause a serious problem if it enters the abdominal cavity.
• Topical, as a sterile ointment: for burns.
MLT: In powder with sesame oil for chapped, bleeding hands and feet, wind/sunburn.
• Not for Lung/stomach bleeding when there are true excess heat signs, external pathogens, or with Lung abscess.
DY: With San qi, the two herbs act to mutually reinforce one another, and together they effectively dispel stasis, stop bleeding, promote granulation and engender muscle (flesh) without producing blood stasis. For such indications as hemoptysis, hematemesis, and bleeding caused by trauma. For internal use, take 3-6g of each herb, powdered, 2-3 times per day. Most bleeding can be stopped within two days. For gastric hemorrhages, it is advised to mix this powder with cool water in order to increase its vasoconstricting mechanism within the stomach.

Dose: 3-15g

Bai Mao Gen – Imperata rhizome – Woolly grass – White grass

Nature: sweet, cold

Enters: Lung, Stomach, Bladder, Large Intestine

Actions: Cools the blood; stops bleeding; clears heat; promotes urination.

Indications:
• Damp-heat: painful urination, edema, jaundice, urinary difficulty.
• Heat in the blood: hemoptysis, hematuria, hemafecia, epistaxis, uterine bleeding.
• Stomach heat: nausea, thirst.
• Lung heat: wheezing.
• Acute nephritis: found to reduce edema, lower blood pressure, normalize examination of urine, shorten duration of the disease.
Li: Beneficial for prostate cancer.
Weng Weiliang, et. al.:
• Bleeding: bai mao gen could be used to treat nasal bleeding, haematemesis, hematuria and uterine bleeding. It had good effects on skin or mucous petechiae, nasal or gingival bleeding and bleeding in sputum.
• Acute glomerulonephritis, acute edema: bai mao gen 250~500g was decocted with 500~1000ml water for 10 minutes with slow fire after boiling. It had good short-term effect on acute glomerulonephritis.
• Acute or chronic infectious hepatitis: bai mao gen decoction was used to treat 200 cases of acute or chronic infectious hepatitis and had satisfactory effect. 33 cases of acute or chronic infectious hepatitis were treated with bai mao gen, xuan shen, dang gui, ren dong teng, sheng gan cao, sheng huang qi, sheng ma, tu fu ling, 25 cases were markedly effective, 6 effective, and the total effective rate was 94%.
• Upper respiratory tract infections: Qing Wen Tang No. 1 (bai mao gen, da qing ye, sang ye, lu gen, sheng shi gao, gan cao) was used to treat 40 cases of upper respiratory tract infections. It had good effects on fever, cough, nasal discharge, poor appetite, thirst, scanty and yellow urine and dry stools. 85% cases had fever allayed within 2 days.

Dose: 9-24g (to 60g when used alone)

 
Mao Hua: the flower
• Sweet, cold.
• Cools the blood, stops bleeding.
• Heat in the blood: epistaxis, hematemesis.
• Less effective than Bai mao gen for painful urinary dysfunction.

Ce Bai Ye – Biota leaf – Thuja orientalis – Cacumen platycladi – Leafy twig of Chinese Arborvitae – “Flat Fir Leaves”

Nature: bitter, astringent, slightly cold

Enters: Lung, Liver, Large Intestine, Heart

Actions: Eliminates phlegm; stops coughing; clears Lung heat; cools the blood; stops bleeding; promotes healing of burns.

Indications:
• Bleeding: hemoptysis, epistaxis, hematemesis, hematuria, hemafecia, uterine bleeding, bleeding gums, bloody dysentery disorders. Mainly for bleeding due to heat in the blood, but, appropriately combined, this herb can be used for cold disorders as well.
• Lung heat: cough, copious phlegm. Especially important in cases of difficult-to-expectorate sputum streaked with blood.
• Topical, as a powder or ointment: psoriasis or early stages of burns over a small to moderate surface area. For psoriasis, the herb can be applied topically and taken as a decoction. It is especially effective for acute conditions.
• Topical decoction for pain.
• Dysentery: powdered Ce bai ye effectively treated 100 of 114 cases of dysentery in one study.
• Hemorrhage due to gastric or duodenal ulcer. One study showed quicker results with Ce bai ye than standard therapy.
• Alopecia: (use tincture) generates new hair, density proportional to frequency of application. Is a 5?-reductase (5?R) inhibitor, decreases DHT. See this and other studies: https://pubmed.ncbi.nlm.nih.gov/26571086/
• Use the herb raw or charred for bleeding.
Dose: 6-15g

Da Ji – Japanese Thistle – Circinum – “Big Thistle”

Nature: sweet, cool

Enters: Liver, Spleen

Actions: Cools the blood; stops bleeding; reduces swelling; generates flesh at sores.

Indications:
• Heat in the blood: epistaxis, hematemesis, hematuria, hemafecia, uterine bleeding.
• Especially effective for vomiting or coughing of blood.
• Topical: for carbuncles, sores, swellings.
• Lowers blood pressure (usually 10-20 mm Hg diastolic).

Dose: 4.5-15g

Di Yu – Sanguisorba root – Burnet-bloodwort root

Nature: bitter, sour, slightly cold

Enters: Liver, Stomach, Large Intestine

Actions: Stops bleeding; cools the blood; reduces fire; eliminates toxicity; promotes healing of non-healing skin ulcers; clears heat, generates flesh, reduces oozing.

Indications:
• Heat in the blood: hemoptysis, hemafecia, hematuria, epistaxis, hematemesis, bleeding hemorrhoids, uterine bleeding, bloody dysenteric disorders.
• Topically (sometimes calcined): burns, sores, ulcers, injuries, eczema. May be powdered and mixed with sesame oil.
• Especially good for bleeding in the lower Jiao due to damp-heat.
• Broad spectrum antimicrobial.
• Reduces seepage, infection rate, mortality, and healing time of burns.
• One study showed significant benefit in eczema (using 30% roasted herb in petroleum jelly).
• Use charred to stop bleeding.
Weng Weiliang, et. al.:
• Primary thrombopenic purpura: Qing Huo Xiao Yu Tang: sheng di, shui niu jiao, bai mao gen, sheng shi gao, 30g each; di yu, dan pi, chi shao, dang gui, 12g each; xian he cao 20g; tu da huang 15g; gan cao 10g. The formula was used to treat primary thrombopenic purpura of Blood Heat type. The other type was treated with another formula. 1 dose every day, water decoction, for 1~3 months. 32 cases were treated, 14 markedly effective, 11 effective, 6 improved and 1 ineffective.
• Nephritis due to purpura: 110 cases of nephritis due to purpura were treated with yu mi xu 30g; bai mao gen, xian he cao, 20g each; zi cao 12g; parched di yu, qian cao, dan pi, 9g each; shi wei, sheng di, huang qi, 15g each; san qi powder 3g (taken with water). 1 dose every day, water decoction. After 30~60 doses, all cases were cured and no recurrence was reported.
• Hemorrhage of the upper digestive tract: Di yu was used in various formulas for the treatment of hemorrhage of the upper digestive tract, and it had good effect.
• Necrotic enteritis: Bai tou weng, bai jiang cao, 15g each; da huang 10g; huai hua 12g; zhi shi, dan shen, bai shao, hou po, 9g each; pu gong ying 25g; di yu, huang lian, huang qin, 6g each; hong hua 3g. 1 dose every day, water decoction. The formula was used to treat 23 cases of necrotic enteritis, 20 were cured and 3 ineffective.
• Dysfunctional uterine bleeding: Chao di yu, shu di, huang qi, dang shen, 30g each; chao bai zhu, dang gui, 15g each; pao jiang, e jiao (melted), 10g each; sheng ma 6g. 1 dose every day, water decoction. After 3~9 doses, all treated 32 cases were cured.
• Skin diseases: Charred di yu powder and vaseline were made into 30% ointment for external application to treat skin diseases such as eczema and ringworm of the feet, etc.. 109 cases were treated, and 47 cured, 50 markedly effective or effective.

Dose: 6-12g

Huai Hua – Huai Hua Mi – Sophora flower bud – Pagoda Tree flower bud

Nature: bitter, slightly cold

Enters: Liver, Large Intestine

Actions: Cools the blood; stops bleeding; clears liver heat.

Indications:
• Damp-heat: bleeding hemorrhoids, hemafecia, dysentery
• Heat in the blood: many forms of bleeding, especially of the lower body/large intestine; also for coughing blood, epistaxis, uterine bleeding.
• Liver heat: headache, red eyes, hypertension, dizziness.
• Topical: tongue bleeding.
• Lowers blood pressure.
• Use charred to stop bleeding.
• Contains rutin and quercetin (anti-inflammatory, reduce capillary permeability, reduce tension in bronchial and intestinal smooth muscle, relieve intestinal spasms, anti-allergic effects, improve coronary circulation by dilating coronary blood vessels, may protect against development of atherosclerosis, more).
HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas
Zhaoxue Lu: As we know, most books mention Huai Hua enters Liver, LI intestine with the function to clear heat, cool blood and stop bleeding. It is commonly used for LI wind with hemorrhoid or blood in the stool. For psoriasis, we usually think it belongs to warm febrile disease and related to skin (Lung). So we use the function of Huai Hua which can cool blood and clear heat from Li to clear the skin. There is a clinical report to use Huai Hua 3g bid after meals every day to treat psoriasis. Huai Hua was ground into power after being dry fried into yellow color.

Dose: 6-15g

 

Huai Jiao: the fruit
• Weaker effect on bleeding than the flower bud, but more effective at draining heat.
• Often used for inflamed hemorrhoids.
• Directs Qi downward (therefore contraindicated in pregnancy).

Dose: 9-15g

Lian Fang Mature – Lotus receptacle – Lotus peduncle

Nature: bitter, astringent, warm

Enters: Liver, Kidney, Spleen

Actions: Dispels blood stasis; stops bleeding; calms the fetus; dispels summer-heat and dampness.

Indications:
• Uterine bleeding, hematuria.
• Restless fetus, threatened miscarriage.
• Summer-heat with dampness: diarrhea in children.
• Recent use: for cervical cancer and pemphigus.
• Use fresh for summer-heat.
Jin: To promote blood circulation, best prepared with vinegar or wine.

Dose: 3-9g

Ou Jie – Node of Lotus Rhizome

Nature: sweet, astringent, neutral

Enters: Liver, Lung, Stomach

Actions: Stops bleeding by astringing; dispels blood stasis

Indications:
• Many forms of bleeding, especially heat in the Lungs or stomach: hemoptysis, hematemesis. Also for chronic bleeding when combined appropriately.
• Heat in the blood: prolonged menstruation.
• Can be cooked as a food
• Use raw for bleeding due to heat in the blood (the fresh herb crushed into juice is even better).
• Partially char the herb for bleeding due to cold from deficiency.
• Ping-Qi Kang includes this herb in his headache/migraine formula.
Jin: To promote blood circulation, best prepared with vinegar or wine.
Yoga: Padma, Kamala, Pushkara, more names
• The lotus is India’s most sacred plant, the symbol of spiritual unfoldment. (See also Lian zi, Lian xin, Lian fang, etc.)
• Sweet, astringent/cooling/sweet.
• P, V-; K+ (in excess)
• Nutritive tonic, rejuvenative, aphrodisiac, astringent, hemostatic, nervine.
• Diarrhea, bleeding disorders, menorrhagia, leukorrhea, impotence, spermatorrhea, venereal disease, heart weakness.
• Opens the first chakra (muladhara) – the root center: for first chakra disorders. (PLB: e.g., self-indulgence, self-centeredness, insecurity, instability, rootlessness, ungroundedness, etc.)
• Calms the mind, subdues restless thoughts and dreams.
• The lotus is sacred to Lakshmi, the goddess of prosperity, and brings spiritual and material abundance.

Dose: 9-15g

Qian Cao – Qian Cao Gen – (Red) Madder root – Rubia

Nature: bitter, cold

Enters: Liver, Heart

Actions: Promotes blood circulation, dispels blood stasis; cools the blood; stops bleeding.

Indications:
• Blood stasis: pain in the flanks, chest, joints in Bi syndrome, trauma.
• Blood stasis: amenorrhea, lochioschesis, early stages of carbuncles.
• Heat in the blood: any form of bleeding, including hematemesis, hemafecia, hematuria, hemoptysis, uterine bleeding, etc.
• Stimulant effect on uteri of post-partum women.
Yoga of Herbs (Frawley & Lad): Manjistha: bitter, sweet/cooling/pungent; reduces Kapha and Pitta, raises Vata
• Alterative, hemostatic, emmenagogue, astringent, diuretic, lithotriptic, antitumor effect.
• Best blood purifier in Ayurveda. Detoxifies the blood, removes obstruction (including in the kidneys and liver).
• Amenorrhea, dysmenorrhea, menorrhagia, menopause, bleeding, kidney, bladder, or gall stones, jaundice, hepatitis, diarrhea, dysentery, trauma, cancer, heart disease, obstinate skin problems, dropsy, rickets, paralysis, herpes.
• For all inflammatory conditions.
• Helps knit broken bones.
• Topical: as a paste for skin discoloration, inflammation, burns, damaged tissue
• Major anti-Pitta herb.
Hsu: Antibacterial, antitussive.

Dose: 6-9g

San Qi – Tian Qi – Panax pseudoginseng or P. notoginseng – “Three Seven”

Nature: sweet, slightly bitter, warm

Enters: Liver, Stomach, Large Intestine

Actions: Stops bleeding; promotes blood circulation, dispels blood stasis, relieves pain, reduces swelling; commonly thought of as a tonic, similar to ren shen.

Indications:
• Bleeding: any form, internal or external, including hematemesis, epistaxis, hematuria, hemafecia, etc. A particularly important herb because it stops bleeding without causing stasis.
• Traumatic injury: the herb of choice for swelling and pain due to falls, fractures, contusions, sprains.
• Blood stasis: pain, including of the chest, abdomen, joints.
• Yin deficiency heat: bleeding (combine with Yin tonics).
• Coronary heart disease, angina pectoris: may replace nitroglycerin.
• May lower blood pressure.
• May reduce serum lipids, cholesterol.
• Effective for Crohn’s disease.
• The liver seems to play an important role in San qi’s ability to stop bleeding internally, since its effectiveness is lost if the portal vein is ligated. Also shortens thrombin time.
Dr. Wei Li: May be beneficial in obesity for weight loss.
Miachel & Lesley Tierra: For internal or external hemorrhages.
• Powerfully dissolves clots, normalizes circulation.
• Increases coronary artery flow.
Hiener Freuhauf: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).
Hong-Yen Hsu (Oriental Materia Medica): Cardiotonic: increases coronary blood flow, decreases oxygen consumption by cardiac muscle, thereby diminishing the load on the heart.
• Lessens lipid and cholesterol levels in the blood.
• Possesses an anti-tumor effect.
• Enhances the immune system.
Sibhuti Dharmananda: Has been successfully employed as an adjunct to radiation therapy of nasal cancer, greatly improving the success of the treatments. Improves immune system functions and promotes blood circulation.
Dui Yao (Sionneau & Flaws):  With Bai ji, the two herbs act to mutually reinforce one another, and together they effectively dispel stasis, stop bleeding, promote granulation and engender muscle (flesh) without producing blood stasis. For such indications as hemoptysis, hematemesis, and bleeding caused by trauma. For internal use, take 3-6g of each herb, powdered, 2-3 times per day. Most bleeding can be stopped within two days. For gastric hemorrhages, it is advised to mix this powder with cool water in order to increase its vasoconstricting mechanism within the stomach.
• With Dan shen to quicken the blood, dispel stasis, nourish the heart, open the network vessels, stop pain, and settle palpitations. For indications such as chest Bi or impediment, i.e. cardiac problems with pain and severe palpitations. For these indications, wine mix-fried Dan shen should be used. This combination treats heart pain no matter what the cause. This action may be reinforced by adding Shi chang pu, Xie bai, Gua lou pi, Gui zhi, and Tan xiang.
• There are two methods of preparation of San qi:
– Uncooked San qi quickens the blood, dispels stasis, and stops bleeding.
– Steamed San qi nourishes the blood, and is not effective for either quickening the blood or stopping bleeding. If San qi is cooked by adding it together with other decocting medicinals, its ability to quicken the blood and stop bleeding is lost. Therefore, for these indications, San qi is more efficient when administered [directly] in its powdered form.
• Modern research has clearly demonstrated that San qi has a definite effect on coronary heart disease, angina pectoris, and hypercholesterolemia.
Eric Brand: San Qi, also called Tian Qi, notoginseng, or pseudoginseng, is an important medicinal substance in Chinese medicine. San Qi comes from the same genus as Chinese and American ginseng, and the plants and their roots have similarities in appearance and odor. All three of these Panax species have some overlapping constituents, though they also have significant differences in their chemistry and clinical use. In contrast to the primarily supplementing American and Chinese ginsengs, San Qi is most well-known for its ability to stop bleeding and quicken the blood.
While San Qi is easy to identify visually, it is not uncommon to see mistaken substitute for San Qi on the market. The substitute, known as Chuan San Qi, is completely unrelated but it is confused with standard San Qi because of similarity in their Chinese names. I first became aware of this issue years ago when I was still in school in California. At the time, I often hung out in Chinatown-style herb shops, and I saw that many shops would refer to the normal San Qi that we learned about in school as Tian Qi, and would dispense a different herb when San Qi was specified. All textbooks clearly state that these two names are synonymous and should both refer to normal notoginseng, and it took me years to learn what that mysterious other herb was.
The true notoginseng is the hard, dense, node-heavy product that most of us are familiar with. The false notoginseng is a sliced, light, and white root product that looks similar to yu zhu (Siberian Soloman’s seal). The white, misidentified product is known as Rhizoma Tupistrae, and it is toxic. The exact species used has not yet been definitively identified, but the genus is known. This plant is a heat-clearing, toxin-resolving substance that should not be used in place of San Qi. True san qi should be very dense, grayish-yellow, brownish-yellow, or black; the true and false products are easily distinguished visually.
Once the correct species is identified, the next issue to be aware of relates to processing methods. For authentic San Qi, we see two different products on the market. In the past, all the best San Qi was exported, and the export grade was colored with coal smoke and coated with insect wax to make it shiny. This causes the roots to have a black, shiny appearance, and the prominence of this processing method for quality San Qi caused many global markets to develop a preference for the black, shiny form. Consequently, we see this black-processed form in herb shops around the world.
Unprocessed San Qi is naturally brownish-yellow, and often slightly gray in color. Depending on the soil and growing environment, it can come out more yellowish or more brownish, but it is quite distinct from the black, shiny form. Regardless of color, the roots have the same characteristic dense, stubby, and nodular shape. San Qi is graded based on size. Small roots are inexpensive, while older and larger roots fetch a premium price.
Weng Weiliang et. al.:
Bleeding due to ulcer
San Qi Bai Ji Tang (experiential formula): san qi powder, bai ji powder, sheng da huang powder, 6g each; xian he cao, duan wa leng zi, 20g each; zhi shi 9g; chen pi, fu ling, 15g each; qing ban xia 10g. 1 dose every day. Modify the formula according to accompanied symptoms. 36 cases of bleeding due to gastric or duodenal ulcer were treated, 34 were cured, 1 markedly improved and 1 improved. The average hemostasis time was 4 days.
Ulcerative colitis
San Qi Zhen Zhu San No. 1: san qi 50g; zhen zhu 50g, er cha 50g, xue jie 50g, bai ji 50g, bing pian 15g, for patients with excessive bleeding. No. 2: san qi 50g, zhen zhu 15g, xue jie 50g, er cha 50g, bai ji 50g, bing pian 15g, da bei mu 50g, for large ulcers. 5~10g powder was added with 50~100 ml physiological saline for retention enema, once daily before sleep, 15 days as a course of treatment, 2~4 courses totally. Among 36 treated cases, 28 were basically cured, 7 improved and 1 ineffective.
Enteritis
San qi was ground into very fine powder, 1~3g, tid, three days as a course of treatment, 1~2 courses totally. 26 cases (17 acute and 9 chronic) enteritis were treated, 23 cured and 3 improved.

Dose: 3-9g (1-3g direct as powder)

 

San Qi Hua: the flower
• Sweet, cool.
• Pacifies the liver; lowers blood pressure.
• Hypertension: dizziness, vertigo, tinnitus.
• Acute sore throat.

Xian He Cao – Agrimony – “Immortal Crane Herb”

Nature: bitter, astringent, neutral

Enters: Lung, Liver, Spleen

Actions: Stops bleeding and diarrhea by astringing; kills parasites.

Indications:
• Treats many forms of bleeding: hemoptysis, hematemesis, hemafecia, hematuria, epistaxis, uterine bleeding, bleeding gums. When combined appropriately, this herb can be used for heat or cold, in excess or deficient patterns.
• Chronic diarrhea or dysentery due to deficiency. Can be used as a suppository for diarrhea.
• Tapeworms.
• Trauma: Xian he cao powder is commonly used in surgery as a hemostatic: hemorrhage or seepage usually stops within 1-2 minutes.
• Topical: use the decoction as a wash for trichomonas vaginitis
• Occasionally used to “astringe” Qi – for fatigue due to overexertion.
Michael & Lesley Tierra:  The calcined ashes of Xian he cao are most effective to stop bleeding.
• For vaginitis due to trichomonas vaginalis, soak a cotton ball in a strong decoction, and insert overnight. Next morning, douche with a decoction of agrimony and yellow dock.
• Can be used to relieve pain and coalesce and strengthen the good cells of the body to resist all kinds of pathogenic influences.
• Recent: valuable for cancer (as in the formula Ping Xiao Dan).
Matt Wood: For liver Qi stagnation: irritability, suppressed emotions (similar to bupleurum).
• Nearly the same as Cinquefoil: Cinquefoil has characteristic leaves made up of five leaflets, like a hand. It (and agrimony) has a magic function to ease problems associated with labor (work with the hands, one’s calling, spiritual work) and the work environment (coworkers, boss, or other facets of the situation). Taking it or keeping some around changes a person’s environment (e.g. for an oppressive or dysfunctional work environment).
• The characteristic mental state of the agrimony patient: tension, frustration, anger, inner torment, feels “caught in a bind,” unable to do the right thing, they constrict their breathing from tension, may hold exhalation back, try to hold back pain and not complain – tension and pain hidden behind a facade – act stoic or jovial.
• Female problems: dysuria, dysmenorrhea.
• The “bad hair day” remedy: tension manifests in the hair – poor growth, frazzled, breaks, patchy, nails break also.
• Intermittent fever, chills, influenza, Shaoyang symptoms.
• Sharp, shooting pain in the kidney region.
• Helps passage of gallstones and kidney stones.
• Also for ulcers on the lower body; skin eruptions; alopecia; toxemia; hypertension; colitis, enteritis.
• Tension related to bed wetting.
• This is wolf medicine.
• Matt Wood usually gives agrimony in low-potency homeopathic doses (12x-30x) or 3 drops of the tincture daily.
Kenner & Requena: Hypoglycemiant, astringent, diuretic, anti-inflammatory, cytophylactic.
• Earth yang, metal yang.
• For diabetes; asthma; jaundice.
Earth: obesity, intestinal mycosis, gout, headache, cataracts, tonsilitis, stomatitis, pharyngitis, aphthous ulcer, infected wounds, contusions, neuritis, cholecystitis with hyperacidity.
Metal: acute bronchopneumopathy with lots of sputum, hemoptysis, headache, tonsilitis, dysentery, hoarseness, EPI with fever, diarrhea, atonic bowel.
Hong-Yen Hsu (Oriental Materia Medica): Hypotensive, anti-inflammatory, antibacterial, inhibits proliferation of some types of cancer cells, regulates heart rate.
IBIS (Dr. Mitch Stargrove, et al): Qualities: bitter, cool, dry
Affinities: liver
Actions: mild astringent, tonic, diuretic, vulnerary
Dosage: tincture: 2 – 4 mL
There is no remedy which is better suited to the treatment of tension, especially that tension to which traditional Chinese medicine refers as Constricted Liver Qi. The patient feels extreme mental tension, torment, as if caught in a bind (see Dr. Bach’s use of Agrimony). There is corresponding physical tension, as if the part were caught in a bind; constricted respiration, harassing cough; sharp pains in the kidneys (Scudder), kidney-stones, bladder and menstrual problems (Ellingwood). This is a traditional remedy for gall-stone passage. The tongue is clear, but sometimes there are longitudinal, oval ulcers. During passage of a gall- or kidney-stone, the tongue is usually dark blue or purple, due to the congestion of blood. The wiry pulse is the great indicator, in combination with the tormented mental state (Wood).
AHPA Botanical Safety Rating: 1
Toxicity: 0
Weng Weiliang et. al.:
Primary thrombocytopenia purpura
Xian he cao, sheng di, 30~60g; hua sheng yi, xue yu tan, fu ling, bai zhu, e jiao, qian cao, dan pi, jiao san xian, mai ya, gu ya, 16g each; gou qi, he shou wu, bai mao gen, ou jie, 15g each; dan shen, zhi gan cao, 9g each. Modify the formula according to accompanied symptoms, 1 dose daily, 3 months as a course of treatment. 30 cases of primary thrombocytopenia purpura were treated, and 16 markedly effective, 8 effective, 3 improved and 3 ineffective.
Purpura nephritis
Yu mi xu 30g; xian he cao, bai mao gen, 20g each; zi cao 12g; qian cao, dan pi, di yu tan, 9g each; shi wei, sheng di, haung qi, 15g each; san qi fen 3g. Modify the formula according to TCM patterns. 1 dose daily. After 30~60 doses, all treated 120 cases were cured.
Hemorrhage of the upper digestive tract
Supplemented Xie Xin Tang (huang lian 6g; huang qin 10g; da huang 8g; xian he cao, bai ji, wu zei gu, 15g each; sheng di yu 30g; ce bai tan 30g; qian cao gen 12g), 1 dose daily. 24 cases of hemorrhage of the upper digestive tract were treated and all were cured.
Colitis
Xian he cao 30g, wu mei 10g, jie geng 9g, zhi sheng ma 6g, bai shao 10g, he zi rou 12g, di jin cao 24g, zhi huang qi 15g, dang shen 12g, sheng bai zhu 12g, gan cao 10g. 1 dose daily, water decoction, 14 days as a course of treatment. Modify the formula according to TCM pattern. 84 cases of chronic colitis were treated, and 69 were cured, 8 improved, 2 ineffective.
Dysfunctional uterine bleeding
Huang qi 15~30g; shu di 10~20G; e jiao 10~15g; xian he cao, di yu, bai shao, shan yao, xu duan, sang ji sheng, tu si zi, 15g each; shan yu rou 10g. Modify the formula according to TCM patterns. 1 dose daily, 6 days as a course of treatment. 56 cases of menopausal dysfunctional uterine bleeding were treated, 38 were cured, 14 effective and 4 ineffective.
Pain due to cancer
Decoction of xia he cao 50~80g was mixed with decoction of gan cao, bing lang, zhi ban xia, bai mao teng and long kui, 1 dose daily for 30 days. After 30 days, 1 dose every other day. 155 cases of pan due to cancer were treated, and 88 cases were relieved.

Dose: 9-15g

Xiao Ji – Small Thistle – Cephalanoplos

Nature: sweet, cool

Enters: Heart, Liver, Spleen

Actions: Cools the blood; stops bleeding; eliminates toxicity; slightly promotes urination.

Indications:
• Heat and toxicity: boils, carbuncles.
• Heat in the blood: epistaxis, hematemesis, hemoptysis, uterine bleeding, and especially hematuria.
• Not as strong as Da ji.
Hong-Yen Hsu (Oriental Materia Medica): Hypotensive, antibacterial.

Dose: 4.5-15g

Xue Yu Tan – Charred Human Hair – “Charred Excess of the Blood”

Nature: bitter, astringent, neutral

Enters: Liver, Stomach, Heart, Kidney

Actions: Stops bleeding; promotes blood circulation; promotes urination; mildly nourishes Yin.

Indications:
• Many forms of bleeding, including hemoptysis, hematuria, hemafecia, and especially uterine bleeding and epistaxis.
• Dysuria, hematuria.
• Usually taken as powder.
• For epistaxis, a small amount of the powder may be blown into the nasal cavity.
• Topical: trauma, pain, bleeding.
• Most Westerners are averse to the smell and idea of this medicine.

Dose: 1.5-9g

Notes on This Category

• These herbs are used to control sweating, diarrhea, coughing, bleeding, leukorrhea, and urination; and to retain Qi, blood, body fluids, Yin, Yang, and Jing.
• These herbs treat only the branch of diseases. The root – usually deficiency of Qi, blood, Yin, or Yang – should be treated concurrently. Most of the herbs in this category are contraindicated in cases of leakage due to excess – e.g., heat, accumulation of dampness, exterior syndromes.

Chi Shi Zhi – Red Kaolin/Kaolinite Clay – Halloysite Clay – “Crimson Stone Resin”

Nature: sweet, sour, astringent, warm

Enters: Large Intestine, Stomach, Spleen

Actions: Astringes the large intestine; stops diarrhea; stops bleeding; promotes wound healing.

Indications:
• Yang deficiency cold: chronic diarrhea, dysentery, especially with blood and mucus (not for damp-heat) or chronic uterine bleeding, excessive menstruation, leukorrhea, bleeding prolapsed rectum.
• Topical: for bleeding from trauma, chronic non-healing sores, weeping damp sores.
• Usually calcined before use.
• Kaolin/kaolinite, one form of clay used as this herb is where the “Kao” in the popular diarrhea remedy Kaopectate came from (the “pect” part came from pectin). Kaopectate is now bismuth subsalicylate.
• The two main forms of clay used as this medicine, kaolinite and halloysite both have the same basic chemical structure: Al2Si2O5(OH)4. As 1:1 “alumino-silicate clay minerals,” they are rich sources of aluminum, which makes Chi shi zhi probably not safe for long term consumption, due to the potential neurotoxic role of aluminum. It may even be worth retiring from the contemporary Chinese medicinal pharmacopaeia.
Hong-Yen Hsu (Oriental Materia Medica): Anti-diarrheal, absorbs abnormally fermented food in the intestines and protects intestinal mucosa; hemostatic.
Subhuti Dharmananda: May help antidote mercury poisoning.

Dose: 9-30g

Chun Gen Pi – Chun Pi – Ailanthus bark or root bark

Nature: bitter, astringent, cold

Enters: Stomach, Large Intestine

Actions: Clears heat; dries dampness; stops leukorrhea; astringes the intestines; stops bleeding; kills parasites.

Indications:
• Chronic diarrhea or dysenteric disorders (research shows very effective for acute bacillary dysentery), especially those due to damp-heat. Particularly useful when there is blood in the stool.
• Damp-heat: chronic vaginal discharge.
• Menorrhagia or uterine bleeding.
• Roundworms.
• Topical: for itchy, tinea-like rashes.

Dose: 3-15g

Fu Pen Zi – Unripe Raspberry – Rubus fruit – “Overturned Basin”

Nature: sour, sweet, slightly warm

Enters: Liver, Kidney

Actions: Tonifies and stabilizes the kidneys, controls Jing and urine; assists Yang, improves vision.

Indications:
• Kidney Yang deficiency: seminal emission, frequent urination, urinary incontinence, enuresis.
• Kidney and liver deficiency: blurry vision, impotence, soreness of the lower back.
• Estrogen-like effects: may be useful in hormonal imbalance (e.g. acne) – as in Hong Jin’s acne formula.
• Astringes without trapping pathological factors.
• The name “overturned basin” may refer to this herb’s efficacy at treating urinary incontinence. After this herb cures the incontinence, the basin (bedpan or toilet) can be turned over because it is empty or is no longer needed.
Weng Weiliang et. al.: Male infertility – Carrot 500g (boiled as diet, and the left water was used to decoct the drugs); tu si zi 60g; nu zhen zi, gou qi, fu pen zi, wu wei zi, bu gu zhi, jiu cai zi, che qian zi, shan zhu yu, 15g each; sang shen, 30g, zhi gan cao 5g. Modify the formula according to accompanied symptoms. 1 dose every day, 30 days as a course of treatment, 20 days~5 months totally.489 cases were treated, and 331 were cured.

Dose: 4.5-9g

Fu Xiao Mai – Floating Wheat (light grains) – “Floating Little Wheat”

Nature: sweet, cool

Enters: Heart

Actions: Tonifies Qi; clears heat; nourishes the heart, calms the Shen; stops sweating.

Indications:
• Yin, Yang, or Qi deficiency: night sweats or spontaneous sweating.
• Yin deficiency: tidal fever.
• Palpitations, insomnia, irritability, emotional instability, disorientation associated with restless organ disorder.
• Enuresis in children.
• Can be used raw or dry-fried until aromatic.
• Very safe herb.
Fu xiao mai may antagonize a wheat/gluten sensitivity – keep this in mind with sensitive patients.
DY: With Huang qi to supplement Qi, nourish the heart, clear heat, secure the exterior, and stop perspiration. For indications such as spontaneous sweating due to exterior deficiency. (Mu Li San) Use stir-fried Fu xiao mai.
• With Ma huang gen to supplement the Qi, nourish the heart, secure the exterior, clear heat, and stop perspiration. The combination is found in Mu Li San for indications such as:
– 1. Spontaneous or profuse perspiration due to Qi deficiency.
– 2. Night sweats due to Yin deficiency.
• These are under-developed grains of ripe wheat which float when the wheat is washed.
• Xiao mai (Huai xiao mai) is the heavy, full grains which sink when washed. Xiao mai is better than Fu xiao mai for nourishing the heart and quieting the Shen for visceral agitation, vexation, sadness.
Fu xiao mai is the blighted grains which, when dried, float on the surface of the water when washed. Fu xiao mai is superior to Xiao mai for stopping perspiration by astringing, eliminating heat (deficiency), and treating spontaneous perspiration, night sweats, or the feeling of heat in the bones.
• Stir-fried Fu xiao mai is more powerful than uncooked Fu xiao mai at stopping sweating.
• Wheat from southern China is reputed to be warm, while that from the north is believed to be cool.
Chen xiao mai is wheat which has been stored and aged. This is preferred by some practitioners, since the more recent wheat, freshly harvested, is too warm in nature. This warmth is lost when aged.
Bai mian is wheat flour. When stir-fried (Chao mian) it supplements the spleen and stops diarrhea.

Dose: 9-15g (DY: to 30g)

Hai Piao Xiao – Cuttlefish bone

Nature: salty, astringent, slightly warm

Enters: Liver, Kidney, Stomach

Actions: Stops bleeding and leukorrhea; controls Jing; neutralizes acid, relieves pain; promotes tissue regeneration; resolves dampness; stops diarrhea.

Indications:
• Bleeding: uterine bleeding, hematemesis, hemoptysis, bleeding from trauma; especially useful for bleeding from deficiency patterns.
• Kidney deficiency: nocturnal emission, leukorrhea, spermatorrhea.
• Acid reflux, epigastric pain, peptic ulcer, foul burps (take uncooked powder).
• Deficiency: chronic diarrhea or dysentery with pain around the navel.
• With rice wine for malaria.
• Topical: chronic, non-healing skin ulcers, damp rashes of long duration, eczema.
• Topical: for bleeding (may be mixed with starch). In tooth extraction, epistaxis, and surgery – is a more effective hemostatic than either plain sponges or gelatin sponges.
Dose: 4.5-12g

He Zi – Chebulic Myrobalan fruit – Terminalia Chebula – Haritaki

Nature: bitter, sour, astringent, neutral

Enters: Lung, Large Intestine, Stomach

Actions: Astringes the Lungs and large intestine; descends Lung and large intestine Qi; eases the throat; stops coughing.

Indications:
• Chronic diarrhea or chronic dysentery due to deficiency (can be used for both hot and cold patterns when combined appropriately).
• Lung deficiency: chronic cough, asthma, wheezing, hoarse voice or loss of voice (can be used for cough due to phlegm-fire obstructing the Lungs, when appropriately combined).
Yoga of Herbs (Frawley & Lad): Haritaki: means it carries away all diseases and is sacred to Shiva (also called Abhaya: promotes fearlessness).
• All tastes but salty; mainly astringent/heating/sweet; balancing to all three doshas
• Rejuvenative, tonic, astringent, laxative, nervine, expectorant, anthelmintic.
• For cough, asthma, hoarse voice, hiccups, vomiting, hemorrhoids, diarrhea, malabsorption, abdominal distention, parasites, tumors, jaundice, spleen disease, heart disease, skin disease, itching, edema, nervous disorders.
• Caution with severe exhaustion, emaciation, or dehydration.
• One of most important Ayurvedic herbs.
• Rejuvenates Vata, regulates Kapha, only aggravates Pitta in excess.
• Feeds the brain and nerves, imparts the energy of Shiva (pure awareness).
• Heals ulcerated membranes.
• Regulates the colon: based on dosage, corrects either diarrhea or constipation; improves digestion and absorption.
• Promotes voice and vision.
• Aids longevity, increases wisdom and intelligence.
• Raises prolapsed organs, checks excess discharges: including spermatorrhea, menorrhagia, sweating, leukorrhea, etc.
• Reduces accumulated and congested Vata.
Triphala, 3 fruit formula: laxative and balancing bowel tonic: haritaki (rejuvenates Vata), amalaki (rejuvenates Pitta) and bibhitaki (rejuvenates Kapha).
Heiner Freuhauf: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.
Hong-Yen Hsu (Oriental Materia Medica): Antibacterial, antiviral, antispasmodic, protects ulcerations of mucosa caused by enteritis or dysentery bacteria.

Dose: 3-9g

Jin Ying Zi – Rosehip – “Golden Cherry Fruit”

ichaNature: sour, astringent, neutral

Enters: Kidney, Bladder, Large Intestine

Actions: Stabilizes the kidneys, controls Jing and urine; astringes the large intestine, stops diarrhea.

Indications:
• Kidney deficiency: spermatorrhea, frequent urination, urinary incontinence, copious leukorrhea.
• Kidney and spleen deficiency: chronic diarrhea or dysentery, prolapsed rectum or uterus, excessive uterine bleeding.
• May lower cholesterol, may reduce atherosclerosis.
• Rich in vitamin C.
Michael  & Leslie Tierra: Acute postpartum uterine hemorrhage (take some of the stem and leaf along with the fruit).
Botanical Influences on Illness: Beneficial for kidney stones.
Hong-Yen Hsu (Oriental Materia Medica): Antibacterial, antiviral, (extract) quite effective for treating uterine prolapse.
Dui Yao (Sionneau): Stops abnormal vaginal discharge.
• With Qian shi to effectively supplement the kidneys, secure the essence, reduce urination, fortify the spleen, and stop diarrhea and abnormal vaginal discharge. This combination, Shui Lu Er Xian Dan, is used for indications such as:
– 1. Chronic diarrhea due to spleen-kidney deficiency. (Use bran stir-fried Qian shi.)
– 2. Urinary incontinence, enuresis, frequent micturition, and nocturia due to kidney Qi deficiency.
– 3. Chronic white vaginal discharge due to spleen-kidney deficiency.
– 4. Seminal emission and premature ejaculation due to kidney Qi not securing.

Dose: 4.5-9g

Lian Zi – Lotus seed

Nature: sweet, astringent, neutral

Enters: Spleen, Kidney, Heart

Actions: Tonifies spleen Qi; stops diarrhea; tonifies kidney Qi, controls Jing; nourishes the heart, calms the Shen.

Indications:
• Spleen Qi deficiency: chronic diarrhea, poor appetite (caution when Qi deficiency has led to Qi stagnation).
• Kidney Qi deficiency: spermatorrhea, premature ejaculation, excessive uterine bleeding, vaginal discharge.
• Heart deficiency: restlessness, insomnia, palpitations, irritability.
• Especially useful for lack of communication between the heart and kidneys.
• Common dietary therapy (use up to 60g).
Lian zi should have its heart (Lian xin) removed.
• All parts of the lotus plant are medicinal. The lotus is the source of at least eight distinct herbs.
Yoga of Herbs (Frawley & Lad): (see also Ou jie, Lian xin, Lian fang) Padma, Kamala, Pushkara, more names (this is India’s most sacred plant, the symbol of spiritual unfoldment).
• Sweet, astringent/cooling/sweet
• P, V-; K+ (in excess).
• Nutritive tonic, rejuvenative, aphrodisiac, astringent, hemostatic, nervine, cardiac and seminal tonic.
• Calms the mind, subdues restless thoughts and dreams.
• Helps open the heart [fourth] chakra: for heart chakra disorders [PLB: e.g., afraid to love, to feel with the heart, to connect with others, to listen to the heart, difficulty being compassionate, emotionally closed, no sense of boundaries around intimacy, impropriety, especially around intimacy ““ see also five element interpretations of fire imbalance].
• Good for devotion and aspiration, improves speech, helps stop stuttering and improves concentration.
• Diarrhea, bleeding disorders, menorrhagia, leukorrhea, impotence, spermatorrhea, venereal disease, heart weakness.
• As a food, 5g can be taken three times daily, with basmati rice or other tonics such as Shatavari and Ashwagandha, suitably spiced and sweetened.
• The lotus is sacred to Lakshmi, the goddess of prosperity, and brings spiritual and material abundance.
Hong-Yen Hsu (Oriental Materia Medica): Relaxes smooth muscle; dilates coronary artery.

Dose: 6-15g

Ma Huang Gen – Ephedra root – “Hemp Yellow Root”

Nature: sweet, neutral

Enters: Lung

Actions: Stops sweating.

Indications:
• Yin, Yang, or Qi deficiency: night sweats, spontaneous sweating, post-partum sweating.
• Similar to Fu xiao mai but stronger (they are often combined).
Ma huang gen closes the pores.
• It can be used topically.
Hong-Yen Hsu (Oriental Materia Medica): Hypotensive, dilates peripheral blood vessels.

Dose: 3-10g

Nuo Dao Gen Xu – Glutinous Rice root

Nature: sweet, neutral

Enters: Kidney, Liver, Lung

Actions: Stops sweating due to deficiency.

Indications:
• Qi or Yin deficiency: spontaneous sweating or night sweats.
• Yin deficiency: fever.
Hong-Yen Hsu (Oriental Materia Medica): Suppresses sweating; sedative; tonic.

Dose: 15-60g

Qian Shi – Euryale seed – Foxnut

Nature: sweet, astringent, neutral

Enters: Spleen, Kidney

Actions: Tonifies spleen Qi, eliminates dampness; tonifies kidney Qi, controls Jing.

Indications:
• Spleen Qi deficiency (and dampness): chronic diarrhea (especially good for children and often cooked in soup).
• Kidney deficiency: nocturnal emission, premature ejaculation, leukorrhea, spermatorrhea, urinary frequency or incontinence.
• Deficiency or damp-heat: vaginal discharge.
• Stronger than Lian zi to tonify kidney Qi and control Jing.
• One of the strengths of this herb is that it has almost no taste.
DY: Stops diarrhea and abnormal vaginal discharge, reduces urination.
• With Jin ying zi to effectively supplement the kidneys, secure the essence, reduce urination, fortify the spleen, and stop diarrhea and abnormal vaginal discharge. For specific indications of this combination, see Jin ying zi in this category.
Weng Weiliang et. al.:
• Prolonged diarrhea due to Spleen deficiency: Qian shi was often used in compound formula in combination with dang shen, bai zhu and shan yao, etc. to treat syndromes due to Spleen deficiency. The following formula was effective on syndromes differentiated as Spleen deficiency, especially those senile patients: dang shen, 15g; fu ling, bai zhu, lian rou, qian shi, chao bian dou, yi yi ren, 12g each; shan yao 15g; sha ren, 6g; chi shao 10g; zhi gan cao 6g, three doses every week.
• Spermatorrhea, premature ejaculation, incontinence of urine or frequent urination due to Kidney deficiency: Jin Suo Gu Jin Wan which containing Qian Shi had good therapeutic effect on spermatorrhea and frequent urination. Supplemented Shui Lu Er Xian Dan (qian shi, jin ying zi, nu zhen zi, 15g each; wu wei zi, shan yu rou, 10g each; tu si zi 12g; lian xu 10g; dang gui 10g; bai shao 10g; zhi gan cao 6g) was effective in treating spermatorrhea, impotence, premature ejaculation, irregular menstruation and leukerrhea, etc..
• Proteinuria due to chronic nephritis: Qian shi, shan yao, 30g each; jin ying zi, huang qi, bai he, huang jing, wu mei tan, 15g; bai zhu, fu ling, 12g; shan zha rou, pi pa rou, 10g each; shui zhi powder 3g (taken with water), tu si zi 20g. The formula was modified according to accompanied symptoms to treat 37 cases of proteinuria due to chronic nephritis, and 31 cases were completely relieved, 1 basically relieved and 5 ineffective.

Dose: 9-15g (to 30g in severe cases)

Rou Dou Kou – Nutmeg – Myristica seed – “Fleshy Cardamom”

Nature: acrid, warm

Enters: Spleen, Stomach, Large Intestine

Actions: Warms the middle Jiao; promotes Qi circulation; alleviates pain; astringes the large intestine, stops diarrhea.

Indications:
• Spleen and stomach or spleen and kidney Yang deficiency cold: chronic diarrhea, daybreak diarrhea (not for damp-heat patterns).
• Yang deficiency cold with Qi stagnation: distention and pain of the epigastrium and abdomen, poor appetite, vomiting.
• Preparation: smash on paper and allow the paper to soak up the oil (otherwise will exacerbate diarrhea); very small doses of the oil (0.03-0.2 mL) directly stimulate the gastrointestinal tract.
• Roast to increase its ability to warm the middle Jiao and stop diarrhea.
• One constituent, myristicin, is an MAO inhibitor and a hallucinogen in large doses.
Yoga: Jatiphala: V, K-; P+
• Pungent/heating/pungent.
• Astringent, carminative, sedative, nervine, aphrodisiac, stimulant.
• For poor absorption, abdominal pain and distention, diarrhea, dysentery, intestinal gas, insomnia, nervous disorders, impotence.
• Increases absorption in the small intestine.
• Reduces high Vata in the colon and nervous system.
• Calms the mind (500 mg in warm milk before sleep).
Tamasic: in excess it can dull the mind.
DY: Scatters cold; disperses distention.
• With Bu gu zhi to supplement spleen and kidney Yang, secure the intestines, and stop daybreak or “cock-crow” diarrhea. For indications such as:
– 1. Chronic diarrhea due to spleen-kidney Yang deficiency. (Si Shen Wan) Use salt mix-fried Bu gu zhi and roasted Rou dou kou.
– 2. Daybreak diarrhea with abdominal pain and rumbling noises due to spleen-kidney Yang deficiency. (Er Shen Wan)
PCBDP: Spasmolytic, anti-emetic, orexigenic, topical anti-inflammatory.
• Decreases prostaglandin levels in the colon, PGE2 inhibitor – has been used successfully in Crohn’s disease.
Dose: 1.5-9g

Sang Piao Xiao – Praying Mantis Egg Case

Nature: sweet, salty, neutral

Enters: Liver, Kidney

Actions: Mildly tonifies kidney Yang; controls Jing and urine.

Indications:
• Kidney Yang deficiency (leading to failure of the kidneys to control the orifices): enuresis, spermatorrhea, frequent urination, urinary incontinence, copious leukorrhea (not for damp-heat), nocturnal emissions (especially when not accompanied by dreams).
• This is the herb of choice for bed wetting in children.
Hong-Yen Hsu (Oriental Materia Medica): Suppresses urination and sweating.
Weng Weiliang, et. al.:
• Children’s enuresis: Sang piao xiao, duan mu li, 12g each; jiu cai zi 6g; ku fan 3g were decocted to 50ml juice. Take the juice before sleep. 50 cases of children’s enuresis were treated, 45 were cured and 5 ineffective.
• Spermatorrhea: Sang piao xiao 10g; tu si zi, gou qi, bu gu zhi, 12g each; sheng long gu, sheng mu li, 25g each; with impotence, add dang gui, bai shao and zhi gan cao, 12g each; wu gong, 2 pieces.
• Shingles: Sang piao xiao was baked with a slow fire to charred ones, and grounded into fine powder, which was mixed with sesame oil into paste and applied to affected areas of shingles, 3~5 days every day. 30 cases were treated and all were cured.
Subhuti Dharmananda: “Sang Piao Xiao San – Example of a Mind-Body Formula”

Dose: 3-9g

Shan Zhu Yu – Shan Yu Rou – Cornus fruit – Asiatic Cornelian Cherry – Chinese Dogwood fruit

Nature: sour, slightly warm

Enters: Liver, Heart, Kidney

Actions: Tonifies kidney and liver Yin; astringes the lower Jiao; astringes sweat; slightly tonifies kidney Yang; stabilizes the kidneys, controls Jing; stops excessive sweating, supports what has collapsed; stabilizes the menses; stops bleeding (weak); may mildly nourish Jing.

Indications:
• Kidney and liver deficiency: dizziness, vertigo, weakness of the lumbar region and knees, impotence.
• Yang collapse or Qi collapse: shock, excessive sweating.
• Kidney Qi deficiency: seminal emission, urinary incontinence, profuse sweating.
• Deficiency: excessive uterine bleeding, prolonged menstruation.
• Difficult to digest.
Dr. Wei Li calls Shan zhu yu the “Ginseng for the Kidneys,” and claims this herb is more of a tonic than an astringent.
Pearls from the Golden Cabinet (Subhuti Dharmananda): For alternating hot and cold (not Shaoyang) due to internal injury to the Jueyin liver system – e.g. extreme liver deficiency causing sudden sensation of heat and cold, and dangerous loss of sweat.
Oriental Materia Medica (Hong-Yen Hsu): Diuretic, antibacterial, antihistamine actions.
Weng Weiliang, et. al.: This herb is indicated in the treatment of diabetes, lumbago, impotence, enuresis, infertility, vertigo, spermatorrhea, functional uterine bleeding.
Chronic pharyngitis:
Yang Yin Jiang Huo Tang (experiential formula): shu di 30g; shan zhu yu, wu wei zi, dan pi, bai jiang can, chuan niu xi, 10g each. Modify the formula according to TCM differentiation, 1 dose every day. Other treating methods were also applied. 15 days as a course of treatment, 32 patients were treated, and 31 were effective.
Diabetes:
shan yu rou, wu wei zi, dan shen, 30g each; huang qi, 40g. Modify the formula according to TCM differentiation, 1 dose every day, 1 month as a course of treatment. 300 cases were treated, and the effective rate was 85%.
Albuminuria due to nephropathy:
Yi Shen Li Shui Huo Xue Fang: shan yu rou, ze xie, dan pi, sang bai pi, 10g each; shan yao, sheng di, huai niu xi, chi shao, 15g each; che qian zi 10g; dan shen 30g; da huang 3~6g. Modify the formula according to TCM differentiation. 1 dose every day. 153 cases were treated, after 6~30 doses, 148 cases’ albuminuria turned negative.
Leucopenia:
Zi Yin Bu Shen Tang (experiential formula): shan yu rou 30g, shan yao, gou qi, huai niu xi, shu di, 15g each; gui ban, e jiao, 6g each; tu si zi 20g, bai zhu, sha ren and chen pi etc. were also added. 1 dose every day, water decoction. After 2~7 days’ treatment, 25 were effective, 1 ineffective. This formula was fit for leucopenia caused by chemotherapy or radiotherapy in the treatment of tumor.
Prostatic hyperplasia:
Tong Qian Tang (experiential formula): shu di, shan zhu yu, 12g each; rou gui, bai zhu, chuan shan jia, dang gui, niu xi, hai zao, kun bu, wang bu liu xing, 10g each; fu ling 20g; ze xie 15g. Modify the formula according to TCM differentiation. 1 dose every day, water decoction. After 30~60 days’ treatment, 48 out of 52 cases were effective.
Stroke in the convalescent stage:
sheng di, nu zhen zi, shan zhu yu, niu xi, chuan xiong, hong hua, dang gui, di long, 10g each; shan zha, 15g; sang ji sheng, ji xue teng, 20g each. Modify the formula according to TCM differentiation. 161 cases were treated, except for 8 ineffective cases, certain effects were obtained.

Dose: 3-12g (30-200g in shock)

Shi Liu Pi – Pomegranate rind

Nature: sour, astringent, warm, slightly toxic

Enters: Stomach, Large Intestine, Kidney

Actions: Astringes the large intestine, stops diarrhea; kills parasites; stabilizes the kidneys, controls Jing.

Indications:
• Chronic diarrhea or chronic dysentery (not for acute), rectal prolapse.
• Abdominal pain due to roundworms (only when worms give rise to chronic diarrhea) – not strong as Shi jun zi.
• Roundworms, tapeworms, topical for ringworm.
• Kidney instability: spermatorrhea, premature ejaculation, excessive uterine bleeding, vaginal discharge.
• Amebic dysentery.
• Not for early stages of diarrhea.
• Should not be taken with oils or fats, in order to prevent absorption of toxin into the system.
• Use charred to stop bleeding.

Dose: 3-9g

Shi Liu Gen Pi: the root bark
• Much stronger at killing parasites, especially tapeworms and roundworms, than Shi liu pi.
John Christopher (The School of Natural Healing): (various parts, especially the root bark) Anthelmintic (taeniafuge, vermifuge), astringent, refrigerant, antibilious, anticancerous.
• Use the rind for sore throat.
Yoga of Herbs (Frawley & Lad): Dadima: (rind, root bark, fruit)
• Sweet variety: VPK=
• The sour variety may aggravate Pitta. The sweet variety may increase Ama.
• The rind is anti-inflammatory to the mucus membranes.
• Use as a douche for leukorrhea.
• Topical (paste) for sores, ulcers, hemorrhoids.
• All parts are stomachic, anthelmintic, especially the root bark.
Hong-Yen Hsu (Oriental Materia Medica): Antibacterial, antiviral, antifungal.

Dose: 1.5-9g

Wu Bei Zi – Gall of Chinese Sumac (caused by the insect Melaphis) – Galla Chinensis

Nature: sour, salty, cold

Enters: Kidney, Lung, Large Intestine

Actions: Astringes Lung Qi; stops coughing; astringes the large intestine, stops diarrhea; controls leakage of fluids; absorbs moisture; reduces swelling; relives fire toxicity.

Indications:
• Lung deficiency: chronic cough.
• Chronic diarrhea, dysenteric disorders, chronic blood in the stool, rectal prolapse.
• Leakage: nocturnal emission, spermatorrhea, excessive sweating, bleeding.
• Topical: as a powder or wash for sores, ringworm, toxic swellings, damp and ulcerated skin.
• Topical: for scar tissue.
• Topical: apply as a paste to the navel for night sweats (from tuberculosis in one study) or asthma.
• Antibiotic against a wide range of bacteria and some viruses.
• Inhibits dental cavity formation (caries). According to this STUDY, “Galla chinensis water extract (GCE) has been demonstrated to inhibit dental caries by favorably shifting the demineralization/remineralization balance of enamel and inhibiting the biomass and acid formation of dental biofilm.”
Hong-Yen Hsu (Oriental Materia Medica): Hemostatic, antibacterial, antiviral, antifungal, stimulates the CNS, regulates the cardiovascular system – improves blood circulation, hypotensive.
Journal of Traditional Chinese Medicine: It was recorded in Ben Cao Gan Mu that Wu bei zi can astringe the Lungs, drain fire, transform phlegm, dissipate red swellings, eliminate toxicity, astringe non-healing ulcers, and lift prolapse of the anus, uterus and intestines. Modern scientific research shows that Wu bei zi contains tannic acid which has can coagulate proteins and blood locally, promoting the healing of ulcers.
• Mouth Ulcers:
Recurrent mouth ulcers are difficult to treat. Dry Wu bei zi powder often produces results within a week. Apply the powder 5 to 6 times a day. Usually the pain will be reduced and ulcers will heal in 7 days.
• Hemorrhoids and Prolapse of the Anus or Uterus:
Wu bei zi can astringe kidney Qi. The kidney opens to the external genital area. So, Wu bei zi can be used for kidney deficiency causing prolapse in the genital area.
For hemorrhoids, after the patient moves their bowels, clean the anus with warm water. Put 5g Wu bei zi powder on gauze and gently apply to the anus. Usually hemorrhoids will heal within a week.
For uterine prolapse mix Wu bei zi powder with sesame oil to make a paste. Apply the paste to gauze, insert into the vagina at night before bed, and remove it in the morning. Recovery will usually occur within 2 weeks.
For anal prolapse, break 60g Wu bei zi into small pieces. Cover with water, bring to a boil, and cook for 30 minutes. While the decoction is still steaming, let the steam bathe the anus. Then wash the anus with the decoction, or sit in a basin of the fluid for 30 minutes. The prolapse will usually be reduced after three washes, with total recovery in a week.
• Spontaneous Sweats and Night Sweats:
It was recorded in Ben Cao Bei Yao that Wu bei zi has a strong function to astringe the Lung. With its cool nature it can clear heat, transform phlegm and stop coughing, and it can also stop bleeding and sweating. Sweating is related to the Lungs. The umbilicus is the key point on the Ren Mai, and the Ren Mai can adjust all the Yin meridians in the body. When Wu bei zi enters this point, it can help the Ren Mai adjust all the Yin meridians in order to astringe sweating.
Traditional Chinese medical theory states that spontaneous sweats are a symptom of Yang deficiency and that night sweats indicate Yin deficiency, but in the clinic this is not always true – we still need to differentiate. However, either type can be treated with topical herbs. The combination known as Long Bei San is comprised of equal parts Wu bei zi powder and calcined Long gu. Mix Long Bei San with a small amount of water, apply to the umbilicus, and cover with an adhesive bandage. Change the application every other day. Usually it takes 2 to 6 applications to arrest the sweating.
• Eneursis and Seminal Emission:
Wu bei zi secures the essence of the kidney and the Qi of the bladder. Accordingly, it is a good herb for the treatment of enuresis and seminal emission caused by kidney deficiency.
For children’s bed wetting, the use of Long Bei San provides good results. For patients with seminal emission, combining Long Bei San on the umbilicus while simultaneously administering an internal formula yields better results.
Modern research shows that Wu bei zi contains tannic acid which can coagulate protein and form a thin membrane to strengthen the filtration capacity of the nephron tubule and increase resorption from the nephron. As a result, it can prevent proteinuria.
• Chronic Diarrhea and Dysentery:
Wu bei zi powder and white pepper powder can be mixed with a few drops of white wine, applied to the umbilicus, and covered with an adhesive bandage. A hot water bottle can be used to warm the abdomen simultaneously. The powder should be changed every other day.
• Toothache:
Zhao Pin Su liked to use Wu bei zi as a topical herb to treat all kinds of toothaches including those caused by wind-heat, stomach fire, tooth decay, etc. Dosage ranged from 10 to 30g. He said Wu bei zi was the best herb for the treatment of toothache, especially when caused by tooth decay. Wu bei zi powder can be applied to the painful spot or it can be decocted and gargled with. Sometimes the toothache stops immediately. Afterwards, the decayed area can be filled with Ru xiang to prevent inflammation.
• Chronic Cough due to Lung and Kidney Qi Deficiency Caused by Excessive Dispersion of the Lung:
(Because Wu bei zi has very strong astringent action, it is not indicated for acute cough caused by an EPI.) Prepare a formula of 100g each of Wu bei zi, Hu tao rou, Mai men dong, and Wu wei zi, grind to a powder, and give 6g twice a day, morning and night. Two to eight weeks of treatment with the above combination produces good results in every case.

Dose: 4.5-9g

Wu Mei – Mume fruit – Black Plum – “Dark Plum”

Nature: sour, neutral

Enters: Liver, Spleen, Lung, Large Intestine

Actions: Astringes Lung Qi; astringes the large intestine; stops coughing and diarrhea; generates body fluids, eases thirst; calms roundworms; stops bleeding.

Indications:
• Lung Qi deficiency: chronic cough.
• Chronic diarrhea, chronic dysentery, blood in the stool.
• Yin deficiency (or Qi deficiency) heat: thirst, wasting and thirsting disorder.
• Roundworms (also for hookworms): epigastric and abdominal pain, vomiting (must purge the patient after calming the worms with Wu mei).
• Occasionally used for abdominal pain and vomiting without parasites.
• Bleeding: uterine, fecal (especially when there are accompanying symptoms of blood deficiency including dryness, thirst, parched mouth).
• Topical (as a paste made by powdering and mixing with vinegar, or in plaster form): protruding lumps on the skin – warts, corns, etc.
• Bensky/Gamble: soften the growth in hot water, remove it, then apply the herb, cover with gauze, and change every 24 hours.
• Bacillary dysentery.
• Stimulates production of bile and contraction of bile duct.
• Partially char when using to stop bleeding.
Dr. Wei Li (Portland, Oregon) gives in large dose for recalcitrant skin disease, such as eczema (20-100g).
Hong-Yen Hsu (Oriental Materia Medica): Pronounced antibacterial effect, antifungal, anti-allergic effect.
Bob Flaws: Mume is a plum picked green in the fifth month. It is then preserved by drying over a slow-baking fire for several days. In Japan, umeboshi is made from this same plum which is pickled with salt and Perilla leaves (called chiso in Japanese). According to Michio Kushi, a leading proponent of Japanese macrobiotics, umeboshi plums “neutralize an acidic condition and relive intestinal problems, including those caused by microorganisms.” Another Macrobiotic teacher, Naburo Muramoto, says: “As medicine the umeboshi plum works miracles. Stomach aches, stomach cramps, migraines, certain types of headaches, and acidity are some of the minor pains these plums can relieve. They also counteract fatigue and act as a preventive against dysentery.”
Wu Mei Wan with additions and subtractions can be used for women with severe dysmenorrhea in turn due to endometriosis with a pattern of damp heat stasis and stagnation, spleen qi deficiency, and even a bit of yang deficiency.
In modern Chinese medicine, Mume has three main uses. First, it astringes the intestines and stops diarrhea. Secondly, it expels worms or parasites. And third, it engenders fluids. However, the Shen Nong Ben Cao says that Mume “precipitates or descends the qi, eliminates heat and vexatious fullness, quiets the heart, relieves pain in the limbs, treats hemilateral withering, insensitivity, and dead muscles, and removes green-blue and black moles and malign diseases.” Likewise, the Ri Hua Zi Ben Cao says Mume “eliminates taxation [read: deficiency]…and treats one-sided withering of the skin with numbness and impediment.” Pain in the limbs, one-sided withering, insensitivity, and dead muscles might certainly be describing an autoimmune condition like MS or amyotrophic lateral sclerosis (ALS). And the Ben Cao Tu Jing says Mume “rules … vacuity taxation emaciation and skinniness” which might also describe certain autoimmune and immune deficiency diseases. Vexatious fullness suggests liver depression qi stagnation, the necessity of precipitating the qi suggests upward counterflow, eliminating heat suggests depressive heat, and quieting the heart, when read together with the other symptoms, suggests yin fire disturbing the heart spirit. Li Dong-yuan did sometimes use Mume in his yin fire formulas. Green-blue and black moles suggest blood stasis, while malign diseases means both injurious diseases and also suggests blood stasis, since static blood is also called malign blood.
Heiner Fruehauf says that a number of medicinals are specifically quieting to the spirit in gu zheng cases. He then goes on to list a number of yin-enriching, fluid-engendering medicinals, such as Radix Glehniae Littoralis (Bei Sha Shen), Bulbus Lilii (Bai He), and Rhizoma Polygonati (Huang Jing). Fructus Pruni Mume likewise engenders fluids. It is also the best known of the commonly used Chinese medicinals for treating worms or parasites. Although Fruehauf does not mention Mume being described in the Chinese gu zheng literature as a typical anti-gu medicinal. I believe it should be. In addition, I think the combination of Mume and Perilla is a very effective one in clinical practice. One can add Mume to anti-gu formulas containing Perilla and/or eat Japanese umeboshi plums as a condiment in their diet. (Perilla, by the way, can also be grown as a self-reseeding garden herb and eaten as a salad green.)
See also BF’s commentary on Zi su ye, where he discusses the use of Mume in combination with dispersing herbs to prevent depletion.

Dose: 3-9g

Wu Wei Zi – Schizandra fruit – “Five Flavor Seed”

Nature: sour, warm

Enters: Lung, Kidney, Heart

Actions: Strongly astringes Lung Qi, stops coughing; mildly nourishes kidney Yin; generates body fluids; stops sweating; controls Jing; stops diarrhea; quiets the Shen and calms the heart.

Indications:
• Lung deficiency or Lung/kidney deficiency: asthma and cough, especially chronic (inhibits leakage of Lung Qi above, nourishes kidney Yin below).
• Yin deficiency: night sweats.
• Yang deficiency: spontaneous sweating.
• Body fluid injury: thirst.
• Kidney deficiency: seminal emission, including nocturnal, vaginal discharge, frequent urination.
• Kidney and spleen deficiency: chronic/daybreak diarrhea, seminal emission.
• Kidney and heart Yin deficiency with blood deficiency: insomnia, dream-disturbed sleep, palpitations, irritability.
• Skin disorders.
• May improve liver function in hepatitis: reduces liver enzyme levels (particularly SGPT).
• Stimulatory effects: improves reflexes, stimulates respiration through a direct effect on the CNS: helps resistance of respiratory depression from morphine.
• Can induce/promote labor.
• Increases visual acuity and visual field.
• Raises acuity of tactile discrimination.
• Adaptogenic.
• Beneficial in neurasthenia.
• Soak in 80-proof alcohol as a medicinal wine for itchiness and irritation of the skin associated with a wind rash.
• Crush before using.
• Use dry for deficiency heat.
• Use wine-prepared for tonification.
Michael & Leslie Tierra: Inhibits loss of physical and mental energy. Its spirit calming effects lie in its ability to heal and prevent loss of psycho-physiological energy.
• Useful for those who tend to feel agitated or scattered.
• Can be taken in wine to calm the heart/Shen.
Hong-Yen Hsu (Oriental Materia Medica): Excites the CNS, increases brain efficiency, regulates the cardiovascular system to improve circulation, antitussive, expectorant, stimulates uterine smooth muscle, strongly antibacterial, cardiotonic, analgesic, cholagogue.
Journal of Traditional Chinese Medicine:
• Insomnia and Memory Loss:
Wu wei zi can nourish Yin and harmonize Yang, astringe Yang into the Yin, balance the zang-fu organs, calm the shen and strengthen the will. Li Pei Shen has an extensively used formula called Wu Wei An Mian Tang, containing Wu wei zi, Fu shen, He huan hua, and Fa ban xia. It is very effective at treating stubborn insomnia.
Typical daily doses: Wu wei zi 50g, Fu shen 50g, He huan hua 15g, Fa ban xia 15g
• Chronic Fatigue and Menopausal Symptoms:
Liu Zhen Ji often used a large dose of Wu wei zi to treat chronic fatigue with difficult recovery after extreme physical labor, and menopausal symptoms.
Typical dose for menopausal symptoms or extreme physical exhaustion: 100g/day.
It is recorded in Yong Yao Fa Xiang that Wu wei zi has the function to tonify the source Qi and astringe dispersed Qi. Modern pharmacological research shows that Wu wei zi can improve human intelligence and efficiency. At concentrations of 5 to 10 mg in the bloodstream, Wu wei zi can improve the attention and balance movement by affecting muscle chemistry. (It also works through enhancement of the cortex.) Wu wei zi can stimulate the smooth muscle of the uterus, so it is not recommended for pregnant women.
• Prevention of Asthmatic Bronchitis:
blockage and rebellion of Qi in the bronchi: recurrent bronchial spasm, shortness of breath, coughing, expectoration of mucus and wheezing
Li Zhen Lin used a method which had been passed on in his family for the treatment of night sweats – application of Wu wei zi to the navel – for a patient who also had asthmatic bronchitis. When the night sweats were gone he found that the asthmatic bronchitis was cured as well. (Overall efficacy rate is about 85%.)
Method of application: grind raw Wu wei zi to a powder and add 70% ethanol. Mix to form a paste and save in a bottle. Take an egg-sized amount of paste, put on the umbilicus, cover with plastic wrap and use tape to fix it in place. It is usually applied before bed and removed the following morning. Re-evaluate the patient after 3 20-day courses.
Pharmacological research shows that Wu wei zi can enhance the body’s defenses against irritants and improve function of the adrenal cortex and the immune system. Shen Que [CV-8] has a biao-ne relationship with the Du Mai, connects with the twelve meridians, five zang and six fu organs, and joins the upper and lower body. Medical research shows the umbilicus is the last place to close during the development of the embryo. Beneath it, there is no adipose tissue, but a number of large blood and lymph vessels and nerves. From an anatomical perspective, the umbilicus is thus an excellent passage for absorption of topical herbs. The properties of Wu wei zi penetrate this passage to act on the human body.
• Treatment of Viral Hepatitis:
Research has shown that Wu wei zi can decrease glutamine- alanine transaminase, the enzyme which converts glutamic acid to alanine – necessary for propagation of the hepatitis virus. The key components in Wu wei zi that can decrease glutamine-alanine transaminase are in the seed of the Wu wei zi fruit. So the correct way to prepare Wu wei zi is to bake it and then grind it into a powder. Take the powder, 3g at a time, three times a day. It also can be made into pills with honey. If cooked in a decoction, it must be ground first.
When using Wu wei zi to lower glutamine-alanine transaminase, we need to be cautious. After glutamine-alanine transaminase is back to normal, we should decrease the dosage of the Wu wei zi. If we use only Wu wei zi to lower the glutamine-alanine transaminase level, it is easy for the patient to relapse. When jaundice appears we should move the blood and dispel blood stasis. It is better to disperse the pathogen than to astringe it. Sometimes only using Wu wei zi can trap the pathogen inside and the disease will progress to severe jaundice or cirrhosis of the liver. Therefore, the best way to treat hepatitis is to combine Wu wei zi with some herbs to move Qi and blood and dispel blood stasis.
• Diabetes:
Wu wei zi is very effective at treating Type II diabetes mellitus (non-insulin dependent). The source of the disease is related to deficiency of the prenatal yuan Qi and postnatal imbalance, causing kidney deficiency and leakage of the Jing, blood, and body fluids. Wu wei zi’s sweet taste can strengthen the spleen, and the sour can astringe. In this case, astringing means storage. The kidney is in charge of the storage of Jing, so Wu wei zi is a key herb to tonify the kidney and treat diabetes. Use a large dosage of Wu wei zi and make it into pills. If the patient has hypertension, add Yi mu cao, and Huai niu xi. If the patient has high cholesterol and atherosclerosis, add Jue ming zi, He shou wu, Dan shen, and Shan zha. If the patient has coronary artery disease, add San qi, Jiang xiang, and Tian hua fen.
The Lung is the upper water passage and the kidney is the lower water passage. Insufficiency of the upper water passage and leakage from the lower water passage are the key causes of polydipsia and glucosuria in diabetes. Wu wei zi enters the Lung and kidney, and it can astringe the Lung and tonify the kidney – this is how it can ease thirst and prevent the leakage of Jing.
• Itchiness and Dryness of the Throat:
When treating dryness and itchiness of the throat, the first herb to consider is Wu wei zi. Wu wei zi nourishes body fluids, eases dryness, and also works for itchiness caused by allergies. When Wu wei zi is added to Shao Yao Gan Cao Tang, Zhen Yue Tang, and Yang Ying Qin Fei Tang, the sour flavor combined with the sweet can produce Yin and body fluids, ease dryness and benefit the throat. This method is widely used in chronic pharyngitis caused by Lung and kidney Yin xu or dryness and itchiness of the throat after chemotherapy. It follows the idea that sour and sweet can produce Yin, as recorded in the Nei Jing.
When Wu wei zi is added to formulas such as Yu Ping Feng San, Jin Fang Bai Du San, Qing Fei San, etc., the sour flavor of Wu wei zi can balance the acrid herbs such as Fang feng, Jing jie, Bo he, etc. In this way, we can disperse pathogenic factors and at the same time astringe the Qi and body fluids to stop the itchiness of the throat. Clinically we use these combinations to treat cough with itchiness and dryness of the throat due to allergic pharyngitis.
Wu Wei Zi Can Constrict the Pupils and Stop Tearing:
It was written in Yong Yao Fa Xiang that Wu wei zi can astringe dispersed Qi and constrict enlarged pupils. It was explained in Yi Xue Zhong Zhong Chan Xi Lu that the sour flavor of Wu wei zi can enter the liver, and the liver opens to the eyes, so Wu wei zi can “astringe” dilated pupils. Because tears are the fluid of the liver, and Wu wei zi enters the liver, it can astringe tears also. However, it cannot treat all forms of pupil dilation and tearing. Due to its warm nature and sour taste, it can treat symptoms caused by liver and kidney deficiency or liver Qi consumption. It was recorded in Yan Ke Liu Jin Fa Yao that Wu wei zi is good for treatment of eye problems caused by liver Qi stagnation, excess heat in the Lung, or spleen Qi xu with dampness.
Three additional guidelines to consider when using:
1. Large doses, from 10 to 20g, can be used with no side effects from long-term use.
2. It can be combined with a small dose of Gan cao, so as to blend sweet and sour and produce Yin. This combination will strengthen Wu wei zi’s nourishing function, and it can be taken for a long time.
3. When cooking Wu wei zi in a decoction we must grind it into a powder first, just as Zhang Xi Chun said. Wu wei zi’s skin is sour and its seed is acrid. So as a whole (when ground to release the contents of the entire fruit and seed) its astringing and dispersing functions are balanced.
• Topical Use for (Non-Healing) Ulcers:
After cleaning the surface of the ulcer, apply a small amount of Wu wei zi powder and cover with sterile gauze. Change the gauze every other day.
When applied in the clinic, we need to wait until all the toxins and unhealthy tissue on the surface are gone. Be cautious not to apply too much powder, because too much will form a scab and cover the surface, which prolongs healing time. Apply a thin enough layer of Wu wei zi powder so that the tissue beneath is still visible.
Dui Yao (Sionneau): With Gan jiang to effectively warm the Lungs, transform phlegm, stop cough, and calm asthma. For indications such as cough and/or asthma with profuse, clear, and white phlegm due to cold in the Lungs, Lung Yang deficiency, or phlegm-cold. For these indications, the combination is used in Xiao Qing Long Tang accompanied by Xi xin. For more details on the mechanisms of the combination of Wu wei zi and Gan jiang, see Gan jiang.
Examine.com: • Bioavailability of Schisandrin lignans is poor in water, and can be enhanced in the presence of fatty acids or a good solvent. Although most lignans appear to be absorbed, some have a relatively greater absorption than each other and they can increase each other’s absorption.
• In general, ethanolic extracts of the fruit are preferred due to higher extraction of lignans. The ethanolic extract per se is sometimes dubbed Wurenchun in traditional chinese medicine.
• Despite all lignans being bioactive and of concern, Schisandrin and y-Schisandrin tend to be seen as the ‘main’ lignans; the comprise 0.5% and 0.3% of the Schisandra fruit by weight, respectively and on average.[3] The lignans tend to be named related to either the plant (lignans that sound like Shisandra) the Japanese tea Gomishi made from Schisandra berries (Gomisin lignans) or the Chinese name for the ethanolic extract of Schisandra, Wuweizi (some of the nortriterpenoids).
• The lignans are also found in the shoot and leaves, just in a higher concentration in the fruits.[13][15] Some of them possess an anti-oxidant capacity.[16] It has been estimated that maximum value of total lignans reaches 6-11% at flowering in the stem and bark of Schisandra Chinensis, in which 3-8% was either Schisandrin, Schisandrol, or Gomisin A.
• Has potential to interact with a large range of pharmaceuticals, and should be used with caution in drug-drug combinations
• Schisandra interacts with Warfarin by increasing clearance rate; consult a doctor prior to using Schisandra fruit extracts if using Warfarin.
• The entire fruit of Schisandra has been shown to activate the PXR receptor in rats, and increased Warfarin clearance rate.[1] It (in reference to Schisandrol B in particular, but also the entire class of lignans in Schisandra[24]) also acts as a P-glycoprotein inhibitor and can increase circulating Paclitaxel concentrations in rats[25] and 300mg fruit extract has been shown to increase the Cmax of talinolol by 51% and the 24-hour AUC by 47%, approximately double the potency of 120mg Ginkgo Biloba.
• Schisandria Chinensis fruit extract is able to inhibit the CYP3A4 enzyme[27] which metabolizes over 50% of pharmaceuticals; this inhibition may be due to the Lignan components, specifically Schisandrin A and B[28] and more potently with Gomisin A.[29] Despite a roughly equipotent inhibition of CYP3A4, the combination Kampo therapy including the fruit extract (Shoseiryuto) did not actually alter subsequent pharmacokinetics of nifedipine, a tracer drug.
• Schisandra lignans as hormetic anti-oxidants underlies most of the therapeutic, preventative, and (theoretically, not yet demonstrated) life enhancing properties of Schisandra Chinensis in most organ systems Schisandra has been demonstrated to reach (brain, liver, lungs, kidneys, spleen, and heart).
• Circulation has been shown to be improved by approximately 9% after consumption of Schisandra at 130mg daily in persons who, although otherwise healthy, had slightly impaired blood flow.
• The direct mechanism may be (in part) due to weak agonism of Estrogen receptors,[41] which increases activity of the NO-cGMP pathway and induces endothelial relaxation. Increase Nitric Oxide circulating after ingestion of about 360mg Schisandra Chinensis extract has been noted in human athletes of both novice and elite caliber.
• In part, subjective improvements in cognition can be attributed to placebo or reductions in stress. Currently, the only human study on cognition related to Schisandra has been conducted under conditions of stress.[45] Schisandra seems to possess adaptogenic properties, reducing the biochemical markers of perceived stress; this effect has been recorded as reductions in corticosterones, and reductions in stress-induced liver damage.
Another possible mechanisms of improved cognition is pertaining to acetylcholine, whereas consumption of Schisandra Chinensis fruits is associated with inhibiting Acetylcholinesterase (thereby increasing levels of acetylcholine) and simultaneously possessing the capacity to enhance Cholinergic signalling in the presence of a ligand.
• Schisandrin B appears to be an active lignan in protecting the heart tissue from myocardial infarction damage via glutathione (primarily in the cardiac mitochondria[51]), but only when preloaded suggesting a preventative effect rather than rehabilitative.
• There is biological basis for claims of Schisandra Chinensis fruit extract (some of the lignans) to benefit the heart organ itself, and it appears to induce these benefits by a hormetic (induce a bit of harm, reap a greater amount of benefit) mechanism.
• Schisandra Chinensis extract appears to be able to increase blood flow and nitric oxide bioavailability, which can compliment the previously mentioned cardio-protective effects.
• In general, research from Russia past suggests Schisandra Fruit extract is able to exert an adaptogenic effect and reduce stress from abnormal temperatures.
• A study in rats suggest that one of the lignans from Schisandra, Deoxyschizandrin, was able to increase memory and cognition in mice with excessive beta-amyloid pigmentation; this was hypothesized to be secondary to its anti-oxidative abilities, and suggests Schisandra may help Alzheimer’s Disease symptoms.[74] Schisandrin B also exerts a general protective effect on scopolamine-induced memory impairment.[75] In this latter study, a preservation of glutathione levels was seen in rats subject to Schisandra.
• Schisandrin was also implicated in enhancing M1 receptor (cholinergic) neurotransmission as assessed by oxotermorine-induced tremors, able to enhance the tremoring effects of the drug while not confering any tremors on its own at this dose; oral doses of 1 and 10mg/kg bodyweight water extract were insignificantly different. [46] Injections of 175mg/kg Schisandrin do induce convulsions, however.
• In accordance with traditional usage of Schisandra as a hypnotic and sedative (and to treat insomnia, historically[77]), a study in mice found that oral administration of 100-200mg/kg bodyweight Schisandra extract was able to attenuate rises in catecholamines and cortisol associated with restraint stress and increase the amount of anxiolytic behaviours of mice (relative to control).[77] Schisandra was more effective than Diazepam at normalizing adrenaline and serotonin changes in stress, but not dopamine.[77] This reduction in activation of the HPA (Hypothalamus-Pituitary-Adrenal) axis seems to extend to exerise, where there is also noted attentuations in cortisol.[69] In rats subject to the same restraint mentioned previously (a research model for Anxiety and Stress Relief), it was found that stress was able to increase tumor growth in rats already harboring tumors; 100-200mg/kg oral Schisandra fruit was able to normalize the immune system biomarkers and oxidation in test rats and reduced the amount of hepatic metastatic nodules.[78] This anti-stress effect has been somewhat replicated in a human study using Schisandra which noted that cognition, accuracy and attention was increased during periods of study by stressed persons using the supplement relative to placebo, but this study was confounded by Siberian Ginseng and Rhodiola Rosea which also share an adaptogenic property.
Without a prior stress, administration of Schisandra at 25-100mg/kg demonstrated an anxiolytic effect and promoted sedation and sleepfulness in rats.
• A study delineating how Schisandra affects the liver practically found that both the anti-oxidative protection (mediated via glutathione induction) and anxiolytic effects of reducing corticosterone were crucial (as psychological stress may adversely affect liver function[89]).[85] Furthermore, Schisandra offers a protective effect on hepatic (liver) tumor cells that are responsive to stress.[78] On the anti-oxidant side of things, induction of glutathione (S-transferase and reductase) and buffering anti-oxidant status prior to chemical insult has been demonstrated to protect against aflatoxin,[90] cadmium,[90] Hepatitis C,[91] and carbon tetrachloride.[92] It is said to confer a protective effect that is not specific for a toxin, but instead general.
• In regards to liver enzymes; Schisandra lignans can reduce a stress-induced increase of ALT from 96.7±6.3IU/L to 29.70-34.76IU/L, with 100mg/kg being more effective than 200mg/kg; the control group in this study had ALT levels at 17.5 ± 4.7IU/L.[85] These benefits have been noted in humans with 260mg Schisandra extract plus 10mg Sesamin daily, and alongside the reductions in liver enzymes (ALT, AST) the increase in anti-oxidant enzymes (glutathione, reductase) as well as a reduction in fatty liver and inflammatory markers was seen; no significant influences were noted on bilirubin.[93] A study on blood flow in humans using half the dose of the previous study found increased blood circulation with no influence on liver enzymes; these humans were healthy, so either the dose or prior disease state may account for the discrepancy.[40]
• It has been demonstrated that Sheng Mai San results in better bioavailability of Schisandrin (a lignan used as biomarker) than does a basic aqueous extract of Schisandra fruit delivering the same about of Schisandrin.[101] Whereas isolated Shisandrin at 5mg/kg delivered an AUC of 31766.4+/-7551.1ug/mL, the AUC from Schisandra was 70209.1+/-29155.0ug/mL and from the Sheng-Mai-San concoction 116697.4+/-35816.4ug/mL.[101] This is a 121% enhancement of average AUC using the whole plant, and a 267% enhancement of average AUC using the three herbs.

Dose: 1.5-9 (6-9g as tonic, 1.5-3g for chronic cough)

Notes on This Category

• These herbs are used to nourish Yin, produce body fluids, and moisten dryness.
• They are often combined with herbs that clear deficiency heat.
• Since many of these herbs are moist and cool, caution should be taken in cases of spleen Qi deficiency or accumulation of dampness in the middle Jiao.
Wei Li: Yin tonics are an important component in herbal formulas for lowering diastolic blood pressure and controlling hyperthyroidism.

Bai He – Lily bulb – “Hundred Meetings”

Nature: sweet, slightly cold

Enters: Lung, Heart

Actions: Moistens the Lungs, generates body fluids, stops coughing; clears heat from the Lungs and heart; calms the Shen.

Indications:
• Lung heat and/or dryness: cough, including with bleeding, sore throat.
• Heart heat with Shen disturbance: palpitations, insomnia with lots of dreams, restlessness, irritability, intractable low-grade fever.
• Can be used alone for insomnia due to Lung Yin deficiency.
• Not as strong as Mai men dong at nourishing Lung Yin.
Dui Yao: The Art of Combining Chinese Medicinals: Nourishes heart Yin.
• Sweet and cold, but moistens without being slimy.
• With Zhi mu to moisten the Lungs and clear heat, nourish the heart and quiet the spirit. For such indications as:
– 1. Vexation and agitation, insomnia, vertigo, thirst related to a warm disease which has damaged Yin or due to Yin deficiency with deficiency heat.
– 2. Dry cough, vexation and agitation after a warm disease.
– 3. Lily disease.
Bai He Syndrome – “Lily disease,” named for the major herb that treats it, is a form of mental depression with depressed emotions, anxiety, taciturnity, a desire to sleep without being able to, a desire to walk without being able to, and a subjective feeling of cold or hot. It follows either a warm disease, in which case it is of sudden and recent onset, or emotional problems which have damaged heart Yin, in which case it is enduring and progressive in nature.
Bai he is also effective for numerous psychological and cardiac imbalances related to heart Yin deficiency: palpitations, deep cardiac pain with a feeling of emptiness in the cardiac region, insomnia, profuse dreams, vexation, agitation, neurasthenia.
• When dry cough is predominant, honey mix-fried Bai he should be used.
• If vexation and agitation or insomnia is predominant, uncooked Bai he should be prescribed.
Heiner Fruehauf: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).
Journal of Chinese Medicine: [BAI HE SYNDROME by Professor Gu Yue Hua, Transcribed by Arne Kausland. Number 40, Sep 1992] The name ‘Bai He’ has two meanings: i. ‘Bai’ means ‘hundred’ and ‘He’ means meeting/communicating’. There is a saying “All the hundred branches (i.e. the channels and collaterals) originate in the Heart and meet in the Lung”. Thus the syndrome mainly relates to the Lung; ii. Bai He is the name of the herb (Bulbus Lilii) in the Chinese pharmacopoeia which nourishes Lung-Yin and Heart-Yin and pacifies Heart-Fire, and is used to treat this syndrome.
The main symptoms of Bai He syndrome are absentmindedness (being in a ‘trance’), abnormal appetite and behaviour, a bitter taste in the mouth, and a slightly rapid pulse. The main zang involved are the Lung and Heart and sometimes also the Spleen. It is generally caused by injury due to excess of the seven emotions, and often begins with depression which damages the Heart and Lung Yin. Sometimes Bai He syndrome develops after a febrile disease that damages the Yin of the Heart and Lung leading to emotional problems.
The Heart stores the Shen; when the Heart is injured, the Shen is disturbed. The ‘intellectual function’ of the Lung is to store the Po. When the Po is disturbed, the patient is usually absent-minded and, because the Po belongs to the Lungs, easily suffers from sadness and grief; when the Po is uneasy the patient suffers from hallucinations. The general treatment principle for Bai He syndrome is to treat the Heart and Lung, concentrating on whichever of these two zang most predominates.
The main patterns of Bai He syndrome are:
1. Yin-Xu of Heart and Lung:
Herbal prescription: Bai He Di Huang Tang plus Gan Mai
Da Zao Tang
Bai He (Bulbus Lilii) 30g
Zhi Mu (Radix Anemarrhenae Asphodeloidis) 10g
Sheng Di Huang (Radix Rehmanniae Glutinosae) 30g
He Huan Hua (Flos Albizziae Julibrissin) 10g
Ye Jiao Teng (Caulis Polygoni Multiflori) 12g
Mu Xiang (Radix Saussureae seu Vladimirae) 9g
Da Zao (Fructus Zizyphi Jujubae) 30g (8-10 dates)
2. Internal Disturbance of Phlegm-Heat
Herbal Prescription: Bai He Huan Tan Tang
Bai He (Bulbus Lilii) 30g
Zhi Mu (Radix Anemarrhenae Asphodeloidis) 10g
Sheng Di Huang (Radix Rehmanniae Glutinosae) 30g
Gua Lou (Fructus Trichosanthis) 10g
Xing Ren (Semen Pruni Armeniacae) 9g
Zhi Shi (Fructus Citri seu Ponciri Immaturus) 10g
Chen Pi (Pericarpium Citri Reticulatae) 6g
Ban Xia (Rhizoma Pinelliae Ternatae) 9g
Fu Ling (Sclerotium Poriae Cocos) 12g
Dan Nan Xing (Pulvis Arisaemae cum Felle Bovis) 10g
Huang Qin (Radix Scutellariae Baicalensis) 10g
Gan Cao (Radix Glycyrrhizae Uralensis) 6g
3. Heart-Yin Xu
Herbal prescription:
Bai He (Bulbus Lilii) 30g
Zhi Mu (Radix Anemarrhenae Asphodeloidis) 10g
Sheng Di Huang (Radix Rehmanniae Glutinosae) 12g
Cao Zao Ren (Semen Ziziphi Spinosae Praeparatae) 20g
Bai Zi Ren (Semen Biotae Orientalis) 20g
Zhu Sha (Cinnabaris) 2g [Could probably substitute Hu po or Long chi -PB]
4. Stagnation of Liver-Qi and Yin-Xu
Herbal prescription:
Bai He (Bulbus Lilii) 30g
Sheng Di Huang (Radix Rehmanniae Glutinosae) 12g
Zhi Mu (Radix Anemarrhenae Asphodeloidis) 10g
Qing Pi (Pericarpium Citri Reticulatae Viride) 6g
Chen Pi (Pericarpium Citri Reticulatae) 6g
Zhi Shi (Fructus Citri seu Ponciri Immaturus) 12g
Wa Leng Zi (Concha Arcae) 15g
Mu Xiang Mian (Powdered Radix Saussureae seu Vladimirae) 6g
Fo Shou (Fructus Citri Sarcodactylis) 6g
• In case of Stomach heat add Huang Lian (Rhizoma Coptidis) 7g and Wu Zhu Yu (Fructus Evodiae
Rutaecarpae) 3g.
• When the condition improves, give Xiao Yao Wan to soothe the Liver and regulate the patient’s mental state.
5. Stagnation of Spleen-Qi and Injury to the Lung
Herbal prescription:
Bai He (Bulbus Lilii) 30g
Sheng Di Huang (Radix Rehmanniae Glutinosae) 15g
Zhi Mu (Radix Anemarrhenae Asphodeloidis) 12g
Gui Zhi (Ramulus Cinnamomi Cassiae) 6g
Cang Zhu (Rhizoma Atractylodis) 15g
Sha Ren (Fructus seu Semen Amomi) 9g
Dai Zhe Shi (Haematitum) 15g
Yu Jin (Tuber Curcumae) 9g
Chuan Jiao (Fructus Zanthoxyli Bungeani) 7g
6. Lung and Kidney Yin-Xu
Herbal prescription:
Bai He (Bulbus Lilii) 30g
Zhi Mu (Radix Anemarrhenae Asphodeloidis) 12g
Sheng Di Huang (Radix Rehmanniae Glutinosae) 15g
Di Gu Pi (Cortex Lycii Chinensis Radicis) 15g
He Shou Wu (Radix Polygoni Multiflori) 18g
Bie Jia (Carapax Amydae Sinensis) 10g
7. Disharmony between Heart and Kidney
[no formula given]
The value of understanding the syndrome of Bai He lies in its practical relevance in the analysis and treatment of patients suffering from depression, uneasiness, absentmindedness, lack of concentration, sadness, grief etc. Since the clinical manifestations of patients with emotional disorders do not avail themselves of clear-cut categorisation (whether in Western medicine or TCM), the broader the understanding of the possibilities the better the weaving of a treatment prescription.

Dose: 9-30g

Bai Mu Er – Wood Ear mushroom – Tremella – “White Wood Ear”

Nature: sweet, bland, neutral

Enters: Lung, Stomach

Actions: Nourishes stomach Yin; moistens the Lungs; generates body fluids; nourishes Lung Yin.

Indications:
• Yin deficiency with Yang rising, especially with emaciation, heat in the five centers (five hearts hot).
• Lung consumption, lung cancer.
• Lung heat: dry, nonproductive cough or blood-streaked sputum.
Li: Useful for chronic hepatitis with Yin deficiency; boosts the immune system.

Dose: 3-9g

Bie Jia – Turtle Shell (Salt-water, Soft-shelled, Dorsal Aspect)

Nature: salty, cold

Enters: Liver, Spleen

Actions: Subdues liver Yang; nourishes liver Yin; softens and resolves masses; promotes blood circulation; promotes menstruation.

Indications:
• Liver Yin deficiency leading to liver wind stirring: trembling, convulsions.
• Yin deficiency: low grade fever or fever in leukemia after chemotherapy, steaming bone disorder, night sweats, consumption.
• Masses or lumps in chronic malaria.
• Chest and flank accumulations causing pain and amenorrhea.
• Heat in the blood: excessive menstruation.
• Cirrhosis: Bie jia softens hardness (of the liver).
• Not as strong a tonic as Gui ban, and unlike Gui ban, Bei jia does not tonify the kidneys. However, Bie jia is more effective at treating palpable abdominal masses, and is less apt (than Gui ban is) to cause stagnation.
• Cook 30 minutes longer than other herbs.
• Liu: stronger than Gui ban at subduing rising liver Yang (but see below)
DY: Clears heat from the Yin division; dispels stasis and scatters nodulation.
• Better than Gui Ban at clearing deficiency heat, but inferior at subduing Yang.
With Gui ban to make Yin and Yang interact, to enrich Yin, clear deficiency heat, subdue Yang, extinguish wind, and stop tremors. For such indications as:
– 1. Tidal fever, steaming bones, and night sweats due to Yin deficiency heat. (Use vinegar dip-calcined Gui ban.)
– 2. Weakness of the limbs, involuntary trembling of the hands and feet, and a red tongue with little or no fur due to a warm disease which has damaged the fluids and which causes internal wind of the deficiency type.
– 3. Headaches, vertigo, head distention and tinnitus due to ascendant hyperactivity of liver Yang.
– 4. Hypertension due to Yin deficiency which causes Yang to rise.
– 5. Abdominal conglomeration, such as hepatomegaly and splenomegaly. (Use vinegar dip-calcined Bie jia.)
Bie jia is incompatible with peach and amaranth.

Dose: 9-30g

 
Bie Jia Jiao: Bie jia gelatin
• Compared to Bie jia, this is richer, more cloying, a strong Yin and blood tonic.
• Commonly used for consumption from deficiency, or exhausted Yin and blood with tidal fever and internal movement of liver wind.
• Dissolve in hot water or a strained decoction.

Dose: 3-9g

Gou Qi Zi – Lycium fruit – Wolfberry – “Goji Berry” (ugh…)

Nature: sweet, neutral

Enters: Liver, Kidney, Lung

Actions: Nourishes kidney and liver Yin; brightens the eyes; mildly moistens the Lungs, nourishes Lung Yin; mildly supports Jing; mildly tonifies Yang.

Indications:
• Kidney and liver Yin or blood deficiency: dizziness, vertigo, poor vision, weakness in the lumbar region and knees, sore back and legs, seminal emission, low-grade abdominal pain, wasting and thirsting disorder, consumption.
• Kidney and liver deficiency where Jing and blood fail to nourish the eyes: blurred vision, poor visual acuity, dizziness.
• Lung Yin deficiency: cough (including consumptive patterns).
• Beneficial in male sterility.
• May protect liver cells and hasten recovery from damage by chemicals.
• Contains extremely potent anti-oxidant pigments.
• Bensky/Gamble classifies this herb as a blood tonic.
Dr. Wei Li (Portland, Oregon): Important herb for sedating liver Yang.
Hong-Yen Hsu (Oriental Materia Medica): May help promote regeneration of liver cells and inhibit precipitation of fat in liver cells.
• Hypoglycemiant; hypotensive.
Dui Yao (Sionneau): With Ju hua to effectively nourish and supplement the liver and kidneys, clear heat, calm the liver, and brighten the eyes. For indications such as blurred vision, diminished visual acuity, “moving black spots in front of the eyes,” fire sparks in the eyes, photophobia, dry eyes with distention and headache, and pain in the lower back and knees due to liver-kidney deficiency. For these indications, the combination is present in Qi Ju Di Huang Wan. Bai ju hua should be used. Ju hua carries the action of Gou qi zi toward the eyes.
• In cases of loose stools or diarrhea due to Qi deficiency or spleen Yang deficiency, it is worthwhile to prescribe stir-fried Gou qi zi in order to lessen its slightly cold and moistening nature, which tends to damage the spleen. However, when prepared this way, the herb tends to be weaker at nourishing the liver and kidneys, blood and Jing.
Subhuti Dharmananda: Lycium fruit is the red berry obtained from two closely related plants, Lycium chinense and Lycium barbarum, naturally occurring in Asia, primarily in northwest China (mainly in Qinghai, Gansu, Ningxia, and Inner Mongolia, but east as far as Hebei and west to Tibet and Xinjiang). The fruits from these species are considered interchangeable, though larger fruits are preferred and are more often found on plants of L. barbarum. Lycium is in the Solanaceae family that yields numerous foods, including some that are yellow to red fruits, such as peppers, tomatoes, and the cape gooseberry (a Peruvian species of Physalis).
The Chinese name for the lycium plant is gouqi and for the fruits is gouqizi (zi is used to describe small fruits); the common name “wolfberry” comes about because the character gou is related to the one that means dog or wolf. The spiny shrub has also been called matrimony vine, for reasons long lost. Carl Linnaeus provided the genus name Lycium in 1753. He is responsible for the species name barbarum, while botanist Philip Miller described Lycium chinense just 15 years later. Lycium is extensively cultivated, especially in Ningxia Province, a small autonomous region formerly part of Gansu, with several production projects initiated since 1987. China now produces over 5 million kilograms of dried lycium fruit each year, most of it for domestic use. The fruits are dried with or without sulfur to yield the market herb, or the fresh fruits may be squeezed for their juice that is then concentrated to preserve it for future use in making various beverages.
TRADITIONAL AND MODERN USES
Although lycium fruit was described in the Shennong Bencao Jing (ca 100 A.D.), its use in traditional formulas was rather limited until the end of the Ming Dynasty period (1368–1644). At that time, it was frequently combined with tonic herbs such as rehmannia, cornus, cuscuta, and deer antler to nourish the “kidney” (as described in Chinese medicine) for the treatment of a variety of deficiency syndromes. This therapeutic approach, using gently warming and “thick” tonifying herbs for nurturing the internal organs, was especially promoted by Zhang Jingyue, whose work is described in the book Jingyue Quanshu(ca 1640). Lycium fruit is depicted by Chinese doctors as having the properties of nourishing the blood, enriching the yin, tonifying the kidney and liver, and moistening the lungs, but its action of nourishing the yin of the kidney, and thereby enriching the yin of the liver, is the dominant presentation. It is applied in the treatment of such conditions as consumptive disease accompanied by thirst (includes early-onset diabetes and tuberculosis), dizziness, diminished visual acuity, and chronic cough. As a folk remedy, lycium fruit is best known as an aid to vision, a longevity aid, and a remedy for diabetes. With the intensive research work done in recent years, reliance on descriptions of centuries-old use of the herb is less important than for many other Chinese herbs, since much is now known about the chemical constituents and their potential health benefits.
Constituents and Actions
The color components of lycium fruit are a group of carotenoids, which make up only 0.03–0.5% of the dried fruit (1). The predominant carotenoid is zeaxanthin (see structure below), which is present mainly as zeaxanthin dipalmitate (also called physalien or physalin), comprising about one-third to one-half of the total carotenoids. Lycium fruit is considered one of the best food sources of zeaxanthin.
Zeaxanthin is a yellow pigment (an isomer of lutein and a derivative of ?-carotene) produced in plants. It contributes to the color of corn, oranges, mangoes, and egg yolks (from dietary carotenoids), and it is also the main pigment of another medicinal fruit recently popularized in China: sea buckthorn (hippophae). When ingested, zeaxanthin accumulates in fatty tissues, but especially in the macula, a region of the retina. It is believed that by having a good supply of this compound, the macula is protected from degeneration, which can be induced by excessive sun exposure (UV light) and by other “oxidative” processes (2–4). Lutein, another yellow carotenoid that accumulates in the macula and provides similar protection, is an ingredient of yellow chrysanthemum flowers (juhua) that are often combined with lycium fruits in traditional Chinese herb formulas to benefit the eyes, including deteriorating vision that occurs with aging and may, in some cases, correspond to macular degeneration. The effective daily dose of these two carotenoids, from food and supplements, has been estimated to be about 10 mg.
Another plant in the Solanaceae family used in Chinese medicine (though rarely), is Physalis alkekengi, the Chinese lantern plant, which contains zeaxanthin dipalmitate as a major active component. In addition, the plant contains some steroidal compounds that have been named physalins, producing some confusion about the use of this term because of its former application to the carotenoid. Physalis is used as a treatment for viral hepatitis, and this effect may be attributed in part to zeaxanthin and also to the steroidal compounds. Physalis is used for treating a variety of inflammatory disorders, perhaps aiding treatment of infections; extracts of physalis have been shown to increase natural killer cell activity when administered to mice.
The red carotenoids of lycium have not been fully analyzed. It is believed that part is due to lycopene, the major red pigment in tomatoes and capsicum fruits. The red portion of lycium has been designated as renieratene; the red color overwhelms the yellow of zeaxanthin and the small amount of ?-carotene, though the fruits often display an orange tinge due to the yellow components.
Benefits of carotenoid intake are thought to mainly arise from prolonged use. Therefore, lycium fruit, as a source of zeaxanthin and other carotenoids, would be consumed regularly to complement dietary sources, boosting the amount of these components available from fruits and vegetables and egg yolks.
Another component of lycium is polysaccharides, chains of sugar molecules with high molecular weight (several hundred sugar molecules per chain). It is estimated that 5-8% of the dried fruits are these polysaccharides (5), though measures of the active polysaccharides are difficult to undertake, since differentiating functional long chains versus non-functional short chains is challenging; this figure for polysaccharide content is likely on the high side. Studies of the polysaccharides have indicated that there are four groups of them, each group having slightly different structures and molecular weights (6). Although referred to as polysaccharides, the functional immune-regulating substance is actually a polysaccharide-peptide mixture; the amino acid chains maintain a critical structure for the polysaccharide.
Clinical effects of polysaccharides are also somewhat difficult to determine because absorption after oral administration of polysaccharides is limited and may be quite variable; it is estimated that less than 10% of the high molecular weight plant polysaccharides are absorbed, possibly as little as 1%. So, most studies of these polysaccharides are done with isolated cells or with injections of the purified component to laboratory animals, yielding results that may or may not occur when these substances are consumed orally. In one clinical evaluation, cancer patients were treated with a combination of IL-2 and activated lymphokine killer cells plus lycium fruit polysaccharides (which are reported to promote the body’s production of these therapeutic substances), in which patients were given an oral dose of 1.7 mg/kg of the polysaccharides (so, about 100 mg for a 60 kg person), with the reported result that the response rate was higher than without the polysaccharides (7). This dose of polysaccharides is quite low compared to usual clinical practice, and further evaluation is needed.
These lycium fruit polysaccharides, like those obtained from medicinal mushrooms and from several herbs (the best known as a source is astragalus), have several possible benefits, including promoting immune system functions, reducing gastric irritation, and protecting against neurological damage. The latter application has been the subject of several recent studies at the University of Hong Kong, where lycium polysaccharides are proposed, on the basis of laboratory studies with isolated neurons, to be of benefit to those with Alzheimer’s disease, though clinical trials have not yet been carried out (8, 9).
The immunological impacts of polysaccharides have been the primary focus of study (10). One of the primary mechanisms of action for these large molecules may be that they appear to the immune system as though they were cell surface components of microorganisms, promoting activation of a response cascade involving interleukins (such as IL-2) that impact immune cells (such as T-cells). Since the plant polysaccharides are not the same as the structures on particular pathogens, but have a more poorly defined quality, the response is non-specific. It is possible that repeated exposure to large amounts of polysaccharides might result in a lessened response, so that this method of therapy is probably best suited to relatively short duration (e.g., a few weeks). Low dosage exposure may result in no immunological responses, since these polysaccharides are present in several foods in small amounts, and the immune system would be protected from reacting to ordinary exposure levels.
A review of research on lycium fruit appearing in Recent Advances in Chinese Herbal Drugs (11), indicates that polysaccharides from lycium fruit enhance both cell-mediated and humoral immune responses. It was reported, for example, that in laboratory animals, a dose of 5–10 mg/kg lycium fruit polysaccharides daily for one week could increase activity of T-cells, cytotoxic T-cells, and natural killer cells; other studies showed that part of the mechanism of action was via IL-2 stimulation. The end response to polysaccharide administration did not appear to be solely a stimulation of immune activity, however. In a laboratory study of lycium on IgE responses, it was noted that lycium fruit reduced antibodies associated with allergy-type reactions, which was presumed to be accomplished through the mechanisms of promoting CD8 T-cells and regulating cytokines; licorice root had a similar effect (12).
Extraction and isolation of polysaccharides in low concentration is simple, as they are soluble in hot water that is used as an extracting agent. Getting a high concentration of polysaccharides is a more significant task. The easiest method is to first produce a hot water extract of the herb (using more than one extraction to get most of the polysaccharides into solution), and then force the polysaccharides out of solution by adding alcohol, in which they are not soluble; then, the liquid is separated off and the residue is dried to produce the finished polysaccharide product. This method will also condense other large molecules. Although small amounts of highly purified polysaccharides can be produced for laboratory and clinical studies, at this time, commercial extracts containing 40% polysaccharides represent the highest concentration available, while 10–15% polysaccharide content from simple hot water extraction is more common.
A third constituent of interest is the amino-acid like substance betaine, which is related to the nutrient choline (betaine is an oxidized form of choline and is converted back to choline by the liver when it is ingested). When added to chicken feed, betaine enhances growth of the animals and increases egg production; it is currently used in poultry farming because of these effects. In recent years, betaine has been included in some Western nutritional supplement products, especially those used for improving muscle mass, using several hundred milligrams for a daily dose. Betaine was shown to protect the livers of laboratory animals from the impact of toxic chemicals; other pharmacologic studies have shown that it is an anticonvulsant, sedative, and vasodilator. It has been suggested that betaine could aid the treatment of various chronic liver diseases, such as non-alcoholic fatty liver disease. Betaine is found also in capsicum, silybum (the source of the liver-protective flavonoid silymarin), and beets (Beta vulgaris, from which betaine gets its name). The amount of betaine in lycium fruit, is about 1% (10), so to get a significant amount, a large dose of lycium fruit would need to be consumed (e.g., 20–30 grams).
The mild fragrance of the fruits is attributed to a small amount of volatile oils, mainly two sesquiterpenes: cyperone and solavetivone (13). The amount present does not have significant pharmacological functions when lycium is consumed in ordinary amounts. The fruit also contains about 0.15% flavonoids, including rutin and chlorogenic acid (14).
Typical Dosing of Lycium Fruit
Lycium fruit is most often incorporated into complex herb formulas, in which its dose is in the range of 6–18 grams. Since other herbs in the formula could contribute significant amounts of compounds such as carotenoids and polysaccharides, this dose may be insufficient if lycium is used as a single herb remedy instead. There have been a few reports of using lycium fruit as a single herb or as a major component in a small recipe. For example, in the treatment of atrophic gastritis, one of the recommended therapies is to consume lycium fruits, 10 grams each time, twice daily (15). In folk medicine, for diabetes it is recommended to consume 10 grams each time, two or three times daily (16). As a food therapy for strengthening the elderly or debilitated, it is cooked with lean pork, bamboo shoots, and typical Chinese flavorings, and the daily dose would be 15–30 grams (17). As a dietary supplement for eye health (2), a dose of 15 grams per day was deemed beneficial in supplying adequate zeaxanthin (estimated at 3 mg/day). A simple tea for decreased visual perception is made from 20 grams lycium fruit as a daily dose (18). Thus, the dose in complex formulas of 6–18 grams shifts to a dose of 15–30 grams when it is the main herb, or about a 2.5-fold increase in the dose.
A tableted formula for benefiting vision, made from extracts of lycium fruit, cuscuta seed (tusizi), bilberry fruit (a type of blueberry), and marigold flowers (source of lutein), is produced by ITM and called Lycuvin (19). Two tablets of the formula (a typical daily dose) provides lycium extractives from 10 grams of the fruit (with about 3 mg of zeaxanthin); cuscuta extractives from 6 grams of the seeds (a good source of the flavonoid quercetin, and with a polysaccharide content similar to that of lycium fruit); 75 mg of anthocyanins (another visual pigment) from bilberry, and 8 mg of lutein. These quantities are all consistent with high supplementation levels suggested in the literature for eye health, particularly of benefit to the macula.
Like other commonly eaten fruits, lycium is non-toxic. Toxicity studies showed that injection of 2.4 grams/kg of lycium fruit extract did not cause adverse reactions; the LD50 by injection was determined to be about 8.3 grams/kg, a large amount (10). There was one recent report of possible hepatic reaction to consumption of a lycium fruit beverage product (20). A possible case of interaction of lycium fruit with Warfarin (coumadin) was reported (21); however, given the high frequency of use of lycium fruit and of Warfarin, the lack of more reports of interaction suggests that the incidence may be very low.
Himalayan Goji Juice
In the U.S., lycium fruit is already better known as an ingredient of the juice product called Himalayan Goji Juice (goji is another transliteration of gouqi), than as an ingredient in traditional Chinese medicine prescriptions or food therapy. The product was developed by Earl Mindell, who is best known for his book “Vitamin Bible” (which now has a 25th Anniversary revised edition). He learned of lycium fruit from a Chinese herbal specialist in 1995, and introduced a juice product in 2003, which is made from the reconstituted extracts of four fruits: lycium, grape, apple, and pear (with pear puree added). It is provided in bottles of 33 fluid ounces (1 liter), with recommended use of 2–4 ounces per day, so one bottle is about an 8–16 day supply. Very quickly, a number of other companies have imitated this popular product, and some have gone on to make other formulations featuring lycium fruit as a primary or secondary ingredient.
Comparing this juice to the lycium fruit described in traditional Chinese medicine is somewhat difficult. The manufacturer indicates: “One liter of Himalayan Goji Juice contains the polysaccharides equivalent of 2.2 pounds [1 kg] of fresh goji berries.” Typically, a dried berry is about one-sixth the weight of a fresh berry (that is, the moisture content of the fresh fruit is about 83%), so a dose of 2–4 ounces of the juice would correspond to 10–20 grams of the dried fruit, which is in the correct dosage range in accordance with traditional recommendations, though higher doses have been used in some applications. Dried lycium fruit can be eaten whole (sold most in one pound bags, about 23–46 doses of 10–20 grams), and can be obtained at a lower cost because it is in crude form. The makers of this juice, and other similar products, proclaim unique benefits to the juice, mainly because of specific selection of berries, compared to the dried lycium fruits readily available from Chinese herb and grocery stores. The juice is a convenient form of administration and also provides other juices (that yield a more acceptable flavor), so the extra expense may be considered worthwhile, while there is little evidence that would support a contention of differing therapeutic effect if similar amounts of the lycium fruit are obtained from drinking the juice or from eating the dried fruits or taking supplements made from lycium extracts.
An ITM Health Protocol with Lycium Fruit
While ITM has advocated consuming dried lycium fruits, in much the way one would eat raisins or other small dried fruits, as a means of getting an adequate quantity of the fruit, it is recognized that many people prefer other methods of consuming herbs, such as tablets. The following protocol, relying on tableted herbs, provides a good dose of lycium fruit along with other herbs that also have the reputation of nourishing the yin, supplementing the kidney and liver (as described in Chinese medicine terms), benefiting the eyes, enhancing immune functions, and protecting against adverse impact of oxidation:
Tremella 14 (Seven Forests): 5 tablets each time, twice daily
Lycuvin (White Tiger): 1 tablet each time, twice daily
China Rare Fruits Blend (Jintu): 2 tablets each time, twice daily
Tremella 14 is a yin-nourishing combination of crude herbs; about one third of the formula is made of equal parts lycium fruit, tremella (a tree mushroom, yiner), and astragalus (huangqi); these three herbs are excellent sources of active polysaccharides. Lycuvin was described above, and is a source of visual pigments, especially zeaxanthin and lutein, as well as polysaccharides from lycium and cuscuta. China Rare Fruits Blend is a combination of medicinal fruits including lycium and hippophae (shaji) as sources of zeaxanthin; the formula is considered especially useful for nourishing skin, hair, and nails. This protocol of three products provides extract and powder from 15 grams of lycium fruit in a daily suggested dose. The cost of such a protocol is similar to that for consuming the juice products. Although many potential benefits are described for lycium fruit, the goji juice, and these tablets, only the claim of providing useful amounts of carotenoids and other pigments for nourishing the retina (especially the macula) can be adequately verified at this time.

Dose: 6-18g

Gui Ban – Turtle Shell – Testudinis (Freshwater / Land, Hard Shelled, Mainly Ventral Aspect)

Nature: sweet, salty, cold

Enters: Liver, Kidney, Heart

Actions: Nourishes liver and kidney Yin; subdues liver Yang rising; tonifies the kidneys to strengthen the bones; mildly nourishes heart blood; cools the blood, stops uterine bleeding; softens hardness; expels stasis; aids in difficult births.

Indications:
• Stirring of wind due to liver Yang rising as a result of Yin deficiency: facial spasms, hand and foot tremors.
• Yin deficiency heat: fever.
• Kidney deficiency: weakness of the lumbar region and feet, retardation in children, poor skeletal development, failure of fontanel to close.
• Heart blood deficiency: palpitations, insomnia, anxiety, poor memory.
• Heat in the blood: uterine bleeding or excessive menstruation.
• Non-healing sores and ulcers.
• Hypertension due to Yin deficiency.
• First choice for Wei syndrome due to kidney and liver Yin deficiency
• Some ancient sources say Gui ban is contraindicated in pregnancy since it softens hardness, expels stasis, and aids in difficult births – but can be used appropriately when baby is due.
• Doctrine of signatures: the turtle is so Yin it hardly moves; regarding its ability to aid in childbirth, it helps coax the turtle (baby) out of its shell (mother).
• Crush before use.
• Frying in vinegar focuses its effects on the liver and makes it easier to crush.
• Cook 30 minutes longer than other herbs.
Dui Yao (Sionneau): Makes the heart and kidneys and the Ren Mai and Du Mai communicate.
• Better than Bie Jia at subduing Yang, but less effective at clearing deficiency heat.
• With Bie jia: See Bie jia in this category for properties and indications of the combination.
Hong-Yen Hsu (Oriental Materia Medica): Antipyretic, analgesic.
Subhuti Dharmananda:

BACKGROUND
The tortoise (gui) is one of the four spiritually-endowed creatures described in the Book of Rites of the Confucian Classics, where it serves as an emblem of strength, longevity, and endurance, and symbolizes the Universe (1). Each of these creatures is associated with a direction and element, the tortoise, usually depicted in conjunction with a snake, represents the north, and is thereby associated with the water, darkness (the color black), and the earth (28), the element which was later put into the five element system in the center.
The tortoise shell was long used in divination, by observing the patterns of cracks that developed when a hot instrument was touched to one of its many “divination points,” and then interpreting the implication of the pattern. The prognostications and insights learned from the cracks were often written right onto the shells, and it is from buried fragments of tortoise shells (along with some mammal bones that were used similarly) that we know the most ancient forms of Chinese writing. The Chinese character bu, which means to divine by looking at the cracks in the tortoise shell as the heat develops them, is represented by two lines depicting cracks. This character became incorporated into numerous others as a radical. Thus, the tortoise and its shell have been an important part of Chinese culture.
Further, the tortoise has been used as both food and medicine since ancient times, and is recorded as being used for these purposes since the Han Dynasty, 2000 years ago. Regarding their inclusion in the Chinese diet, E. N. Anderson comments that “Animals that are very tenacious of life, or very unusual-looking and -acting, are regarded as having special power; they are supplementing (bu). Notable supplementing foods are pangolins, raccoon dogs, soft-shelled turtles, tortoises, snakehead fish, birds of prey….(3)” Although the tortoise is not a major food in China today (turtles have long been preferred over tortoises for food), it remains one of the foods included in some diets. Anderson also points out that “During Han, and throughout Chinese history, the boundary between medicine and food was so vague as to be non-existent in practice. Many things were purely medicines, but medicines often became foods if people learned to like them; many foods became merely medicines when people stopped relishing them….”
ANIMAL MEDICINES AND THEIR CONSTITUENTS
Tortoise shells were described as medicines in the Shennong Bencao Jing (4), listed there as guijia (tortoise scale). They have become one of the standard items of the Materia Medica, with consistent use since the earliest recorded medical books. In fact, shells, along with similar animal materials, such as scales, antlers, and skins, are the most commonly used animal substances in the Chinese Materia Medica. Among these, oyster shell is probably the most widely used, followed by deer antler, tortoise shell, and pangolin scale, with lesser amounts of donkey skin gelatin and turtle shell being utilized, though still important to Chinese practice. These materials are rich in collagen and calcium compounds; collagens are the proteins that help determine the overall physical structure and the calcium compounds contribute to rigidity. Pangolin scale, as well as other animal materials such as cicada slough, snake slough, and horns (rhino, antelope, buffalo), are comprised mainly of another protein, keratin, which is similar to collagen; turtle and tortoise shells, as well as deer antlers contain some keratin (the hairs of antler velvet are mainly keratin).
Oyster shell, which is extremely hard, is mainly comprised of calcium carbonates and calcium phosphates with relatively little protein, while donkey hide is mainly comprised of collagen with a little calcium; the other materials mentioned above have intermediate content. As an example, deer antler in velvet (which is the most studied item) contains about 50% protein, with about half of it in the form of collagen that can be converted to gelatin. It also contains calcium carbonate, calcium phosphate, and calcium chloride, making up about 50% of the antler, and the amount of those components increases as the antler ages and becomes ossified (hardened), with a decline in the amount of collagen and other proteins. Tortoise shell and deer antler also contain chondroitin sulfate, a protein-polysaccharide complex that has recently been utilized to treat joint degeneration (it is a building block of the cartilage, comprised mainly of glucosamine). Small amounts of cholesterol and other animal substances are also present in the shells, scales, and skins. An alcohol extract of deer antler (alcohol doesn’t solubilize collagen or calcium), called pantocrine, is reported to have hemopoietic and androgenic activity; its ingredients have not been reported. Presumably, tortoise shell also contains some substances that contribute similar kinds of activity. A 70% alcohol extraction medium solubilizes 2–3% of the substances in tortoise and turtle shells (31). Traditionally, antler is said to tonify and open the governing vessel (dumai) while tortoise shell tonifies and opens the conception vessel (renmai), the two vessels that run along the midline of the body, back (yang) and front (yin), respectively. Perhaps there are slightly differing constituents that can be found to explain the differing attributes. The Chinese interpretation may have originated with the observation of the natural materials more than from observation of physiological responses: the antler arises from the back and top of the deer’s head (yang) and the plastron protects the tortoise’s underbelly (yin).
Tortoise shell, as a medicinal agent, is most often utilized in rehmannia-based formulas that nourish the yin and blood and settle the yang (5). Relatively little is known of the pharmacology of the individual herbs of these formulas, though the overall effects include changes in hormones and hormone receptors. It is possible that tortoise shell provides a nutritional component to some formulas, with calcium and protein, though the flesh of the tortoise would be a better source of protein. Until recently, oyster shell calcium was the main source for calcium in Western nutritional supplements (now, more absorbable forms are often used instead); these supplements are reputed to have several medicinal applications, especially for calcium-deficient individuals.
The use of animal substances, such as tortoise shell, in the modern practice of natural healing is somewhat unusual for Westerners, many of whom view herbalism as a practice involving only plant materials (whereas Chinese “herbs” include minerals and animals). Indeed, for many Westerners, the use of herbs as a standard part of health care is often allied with practices, such as vegetarian diet, that differ from standard Chinese approaches and that would eliminate from consideration the ingestion of animal-derived medicinals. The use of tortoise shell is of particular concern to Westerners because some tortoises have been placed on the endangered species list, and are thereby prohibited from collection and trade. The tortoise shells used in Chinese medicine are obtained from aquatic but land-based tortoises, which are not included on the endangered species list, unlike sea tortoises or some desert species. However, due to the modernization of China (including plans to install a major dam across the Yangzi River), along with its large and still growing population, even these land tortoises may become endangered in the future. Increasing efforts are being made in China (and elsewhere) to raise the tortoises.
SPECIES AND SOURCE
According to the 1995 Chinese Pharmacopoeia (6), tortoise shell (guiban) is obtained from Chinemys reevesii; this is the same species that has been specified in earlier editions of the Pharmacopoeia of the PRC (7) and other sources (5, 8, 9, 10, 11). This is a land tortoise (Figure 5), found in rivers, lakes, and marshes, which is known in the West as the Reeve’s tortoise. It is particularly prevalent in the Yangzi (Yangtze) River region, with most of the commercial supply harvested in Hubei, Hunan, Jiangsu, and Zhejiang Provinces, though also obtained from Guangdong, Sichuan, Guizhou, Fujian, Shaanxi, and Henan Provinces (6, 12, 13). Two substitute species obtained 3 from Anhui Province, Cuora amboinensis and Cuora flavomarginata, have been raised and sold on the market, but are not officially-recognized substitutes (14, 16). The latter species is thought to be the one denoted as shuigui in Li Shizhen’s Ben Cao Gang Mu (15). Other substitutes include Mauremys mutica and Testudo elongata (11). Another tortoise, Eretmochelys imbricata, is used as a separately listed item in the Chinese Materia Medica, known as daimao (Figure 6).
Although the Reeve’s tortoises and some of the substitute species are raised in China for their shells (17), there is still a huge natural supply and the majority of the shells are obtained from the wild resources. They can be collected all year round, but are usually obtained in autumn and winter. Tortoise collection, like that of fish in the same region, is mainly accomplished by use of nets. PROCESSING
The bottom part of the Reeve’s tortoise shell, known as the plastron, is the desired item; by contrast, for daimao and for the turtle (biejia), the top part of the shell, called the carapace, is used. It is not clear why the plastron was chosen, other than the historic value of the plastron in divination. Recent analysis shows that the tortoise carapace has twice the amount of extractable gelatin as the plastron (22), with no difference in composition; similarly, the carapace of the turtle has about twice the water-soluble protein, mainly gelatin, as the tortoise plastron. In a report on conserving drug resources (41), it was noted that the shell (carapace) of the Reeve’s tortoise could be used along with the plastron, as they have similar activities.
The plastron is separated from the flesh and skin of the animal after the whole carcass has been boiled, steamed, or scalded in hot sand. In earlier times, the plastron was separated after letting the animal partially decay in cool water (18); the method of heating before drying is more sanitary and quicker. If 20% lime water is used in place of clear water, the process of cleaning the plastron is even faster (19). Modern efforts at obtaining the medicinal plastron are aimed at improving the speed of the process and alleviating some of the difficulties (e.g., exposure to smoke and flue dust during the cooking, bad smell of the processed material due to decay), while maintaining or improving the content and extractability of the active components (20). A typical water processing method used in modern times involves steeping the shells in clear water for two days, steaming on a strong fire for about an hour, putting them into warm water, then scraping off the non-medicinal parts, and drying the plastron. A comparison of the chemical composition of tortoise shells processed by old and new methods was undertaken and no significant differences were noted (21). However, the details of processing are important: in a study of processed tortoise shell and turtle shell (29), it was shown that proper processing procedures could yield up to twice as much water-soluble substances.
Vinegar processing is the main additional method used by the Chinese. The plastrons isolated by the boiling method are first rapidly heated in a hot pot and then immediately dipped into vinegar; this process can be repeated. According to the report in Pao Zhi (30), the raw tortoise shell is mainly used for treating vertigo, tinnitus, deafness, headache, and convulsion due to wind agitation of liver yin deficiency (i.e., it settles yang, much like oyster and haliotis shells), whereas the vinegar-treated tortoise shell is appropriate for treating nightsweating, weakness of back and legs, insomnia, heart palpitations, and other disorders due to deficiency of liver and kidney (i.e., it nourishes yin and blood, much like rehmannia, ho-shou-wu, and lycium).
Tortoise shell gelatin is obtained by boiling the plastrons; the collagen is converted to gelatin during this process and is then formed into small hard blocks. The gelatin is especially used for treating impotence, low back pain, and uterine bleeding due to kidney essence deficiency. Turtle shell gelatin (biejia jiao) is made as a medicinal product and is also used to treat uterine bleeding; it is also used for hemoptysis associated with tuberculosis, but is not indicated for the kidney deficiency symptoms of back pain and impotence. According to the report in Dui Yao (38), 4 when the turtle and tortoise are combined, they “make yin and yang interact; in addition, together, they enrich yin and clear deficiency heat, subdue yang, extinguish wind, and stop tremors.”
MEDICINAL PREPARATIONS AND DOSAGE
In traditional Chinese formulas, tortoise shell is most often included in pills, with about 2 grams of shell per daily dose (similar to the amount of deer antler or oyster shell prescribed in pill form). Tortoise shell is also used in decoctions, in which case it is to be boiled for some time before adding other materials, since its gelatin and calcium are very slowly extracted. The dose of plastron to be used in decoction is generally 9–24 grams for a one day dose, though in several reference texts up to 30 grams is recommended. Tortoise shell gelatin may be powdered for making pills or may be added to the hot strained decoction after the other herbs have been thoroughly boiled; that is, the gelatin is not cooked further, but simply dissolved into the hot liquid.
The difference between dosage of tortoise shell used in decoctions versus pills is large, about 10:1, but this difference is relatively easily explained. Whereas the shell is very poorly soluble in hot water, yielding only a small fraction of the active constituents to the decoction, the shell is dissolved readily by stomach acid and is well extracted in the digestive system.
CHEMICAL CONSTITUENTS
Calcium compounds make up about half of the tortoise plastron and turtle carapace (31). The calcium content of the plastron, when used in the dosages recommended by the Chinese texts, contributes a significant amount—several hundred milligrams—compared to the currently recommended nutrition levels of about 1 gram. The typical Chinese diet is often low in calcium. Therefore, a course of therapy using tortoise shell in the amount of several grams per day may treat those conditions which are responsive to calcium supplementation. In the West, calcium citrate, calcium carbonate, bone meal (calcium hydroxyapatite), and other preparations are available in tablet, capsule, and liquid forms that can easily provide amounts similar to the Chinese herb preparations with tortoise shells. Also, the Western diet includes milk products that provide considerable amounts of absorbable calcium; by contrast, the Oriental diet is essentially free of milk products, and vegetable-source calcium is of variable availability (e.g., oxalates in the vegetables render much of the calcium unabsorbable).
The bone disease rickets, which is due to impaired deposition of bone calcium in children, has been treated in China with shell formulas. For example, in a study (36) involving several hundred cases, Longmu Zhanggu Tang was administered. It is comprised of tortoise shell, oyster shell, astragalus, atractylodes, codonopsis, hoelen, dioscorea, schizandra, jujube, licorice, and gallus. The tea was made with 15 grams of the materials, and administered three times daily (thus, 45 gram daily dosage). Among 278 cases treated, it was reported that serum calcium and phosphorus levels increased, and bone mass (as detected by x-ray analysis) improved; nearly all symptoms were alleviated. A control group of 200 cases received cod liver oil (source of vitamin D), calcium, and calciferol. The effects were the same, except that the herb infusion, which included several spleen tonic herbs, was better in improving appetite. These results suggest that the calcium provided by the shells, like that provided to the control group as a supplement, was a key component of treatment.
Collagen, a fibrous protein that is converted to gelatin by boiling in water, makes up about 7% of the tortoise plastron. Collagen is the most abundant protein in higher animals, making up one-third or more of the total body protein of vertebrates, with most of it present in specific body structures (e.g., skin, bones, nails, hooves). The collagen forms a network of tough but pliable fibers (Figure 7) that are partially or completely solidified by calcium carbonates and phosphates. The plastron is formed basically in the same way that bones and horns are made, and is sometimes described as an exoskeleton.
It is unclear whether there is anything unique about tortoise collagen and gelatin compared to that obtained from other sources, such as deer antler or donkey skin. In fact, relatively little is known about the medicinal value of these proteins. Recently, interest has developed in the ability of ingested collagen to inhibit arthritis (perhaps by deflecting immune attacks against the joints to the ingested collagen) and for its ability to inhibit angiogenesis (blood vessel formation) as a means of inhibiting tumor growth. In the West, collagen from chicken bones has been tested for arthritis treatment, while collagen from sharks and cattle has been tested for cancer treatment. There may be some correlation with traditional uses of these substances in China. Bones, such as tiger, dog, and pig bones, have been used for arthritis treatment in traditional Chinese medicine. Deer bone gelatin was given orally at 10 grams twice daily in a trial for arthritis treatment (43); of 124 cases treated, more than half had marked improvement or complete resolution of symptoms with 10–20 days typical treatment time. Wang Weilan, a specialist in arthritis treatments (39) frequently recommended gelatins for treatment of deficiency-type arthritis. For example, in cases of soreness and pain of the back and spine, enlargement of the joints, sore legs, painful heals, inability to raise the upper limbs, difficulty lifting the legs, and in persons with obvious weakness, he prescribes a complex formula that includes tortoise shell, turtle shell, donkey skin gelatin, and deer antler gelatin. During the phase of remission, when there is absence of redness and swelling, but there is severe limitation of movement and rigid deformation, he recommends a complex prescription that includes tortoise shell gelatin and deer antler gelatin. He stated that “Deer antler gelatin and tortoise plastron gelatin warm and strengthen the conception and governing meridians. Since they are derived from an animal source, they are very compassionate to human beings; thus, they can invigorate the bone and replete the marrow. They are essential in the treatment of the late stage rheumatoid arthritis (deformity of joints, osteoporosis, defective cartilage of the joint surfaces, etc.). Their use is in accordance with the old saying: use the bone to tonify the bone— the seeking of the similar qi.”
It is possible that gelatin polypeptides (fragments after partial digestion) contribute to inhibition of bleeding, perhaps by a mechanism similar to that of carbonized materials (which the Chinese frequently employ to stop bleeding). In a study of treatment of vaginal bleeding in women above age 40 (37), those diagnosed with weakness of the chong and ren meridians (conception and penetrating vessels), were administered tortoise shell, deer antler gelatin, donkey skin gelatin, rehmannia, dioscorea, cornus, lycium, cuscuta, rubia, and schizandra. Most of the women so treated were cured of bleeding or had reduced bleeding. Other formulas were used to treat bleeding associated with uterine fibroids (turtle shell, which is reputed to resolve masses, was included).
Westerners tend to get little gelatin in the diet, some coming from soups made from animals (when bones, tendons, and/or skin are included in the cooking) and a very slight amount coming from gelatin-based desserts. It has been proposed that gelatins may provide a nutritional benefit for the collagen portions of the body (e.g., gelatin to improve the nails), and one of the accompanying compounds, chondroiton, has been shown to nourish the joints.
There are also small amounts of fats, magnesium, trace minerals, such as zinc, and vitamins, including Vitamin D, in the tortoise shells. As with other natural calcium sources, there are small amounts of lead, but not enough to be of concern.
It is still difficult to explain some of the traditional indications for tortoise shell (see below) based on the limited knowledge of its constituents and their effects. Persons who have habitual low levels of calcium in the diet may experience health improvements when tortoise shell is used in adequate doses due to the calcium and protein it contains (gelatin may enhance calcium absorption); the protein contribution of tortoise shell is only significant when the plastron is used in decoction at high dosage. There may be substances in the shell that stimulate the body to produce hormones or generate another response that would explain the traditional indications, but these substances have not been identified. In one frequently cited study (23), it was shown that both rehmannia and tortoise shell could affect beta-adrenoreceptors in rats with induced hyperthyroidism, thus alleviating some of the symptoms of the thyroid disorder. A shell-based formula has been clinically tested for treating Grave’s disease, a hyperthyroid condition (34): twenty-five patients were treated with a decoction that included turtle, tortoise, and oyster shells, plus astragalus, codonopsis, polygonatum, scrophularia, brassica, arisaema, and prunella. This formula tonifies qi and nourishes yin, 6 while the latter four herbs are used for treating a swelling in the throat that is due to qi stagnation and phlegm accumulation (see Treatment of thyroid diseases with Chinese herbs). According to the report, after administering the decoction three times daily before meals for three weeks, along with the Western drug methimazole and, if needed, propranolol, 14 of the patients showed complete remission of symptoms, and 10 others had partial but clinically significant remission.
COMPARING TRADITIONAL AND MODERN INDICATIONS FOR USE OF TORTOISE SHELL
According to the Shennong Bencao Jing, tortoise is salty and balanced. It mainly treats “red and white leaking” (this is a usual description for uterine discharge, meaning uterine bleeding and leukorrhea, respectively), “breaks concretions and conglomerations” (this is the usual description for masses, especially those that occur in the abdomen), and cures “malaria, the five hemorrhoids, genital erosion, damp impediment, heaviness and weakness in the limbs, and non-closure of the fontanel in children.” The original uses of tortoise shell differ from many of the modern applications, which emphasize nourishing yin and blood and calming agitated yang. Today, turtle shell is preferred over tortoise shell for resolving masses, and oyster shell is more frequently used than tortoise shell for “white leaking.” Heaviness and weakness of the limbs is the main indication from ancient times that is still deemed important today.
As an example of the elaboration of uses in modern practice, the English-Chinese Rare Chinese Materia Medica (11) states the following actions and indications:
1. Nourishing yin and suppressing hyperactive yang. It is efficacious in the treatment of dizziness due to hyperactivity of yang caused by deficiency of yin, or, of stirring-up of endopathic wind of deficiency type resulting from impairment of yin in the course of febrile disease.
2. Reducing fever of deficiency type. It is efficacious in the treatment of hectic fever, consumptive fever, and night sweat, all due to deficiency of yin.
3. Tonifying the kidney and strengthening the bones. It is efficacious in the treatment of flaccidity and weakness of loins and feet, chondropathy (cartilage disorder), and infantile metopism (non-closure of fontanel).
4. Nourishing the blood and tonifying the heart. It is efficacious in the treatment of palpitations, insomnia, and amnesia due to deficiency of the heart.
Another elaboration that provides good insight is from the Advanced Textbook on Traditional Chinese Medicine and Pharmacology (5):
1. To replenish yin and pacify yang. Indications: Kidney yin insufficiency leading to hyperactive yang in deficiency conditions marked by hectic fever and night sweating, for which it is often prescribed along with cooked rehmannia, anemarrhena, and phellodendron, as in Da Buyin Wan. Late stages of febrile diseases with consumption of yin fluid and hyperactivity of deficiency wind marked by dizziness and convulsion. For such cases, it is often combined with oyster shell, turtle shell, and raw rehmannia.
2. To nourish the kidney and strengthen the bones. Indicated for insufficiency of the liver and kidney marked by weakness of the lower back and limbs, weakness of the muscles and bones, and retarded and incomplete closure of the fontanel in infants, for which it is often combined with cooked rehmannia, achyranthes, and cynamorium.
3. To strengthen the meridians and check bleeding. Indicated for yin deficiency and blood heat in women marked by menorrhagia or metrorrhagia, for which it is often prescribed along with ailanthus, peony, and scute.
The treatment of flaccidity and weakness of loins and feet (alternatively described as weakness of the lower back and limbs) corresponds to treatment of heaviness and weakness in the limbs from the Shennong Bencao Jing; the treatment of uterine bleeding, corresponds to red leakage; and there is common mention of closure of the fontanel, connecting the ancient and modern uses. It is possible that the treatment of fever of deficiency type and treatment of malaria make reference to a common concern, since malarial fevers may have this appearance. However, most references to malarial fevers, both ancient and modern, do not indicate a yin-deficiency type syndrome.
TRADITIONAL PRESCRIPTIONS RELYING ON TORTOISE SHELL
Whatever the indications for the tortoise plastron in modern Materia Medicas, its history of use is perhaps best observed via the well-known formulas that rely on it as a major ingredient. The traditional prescriptions that utilize tortoise shell as a key ingredient may be classified into three groupings:
1. Formulas for yin deficiency accompanied by deficiency fire. These formulas include Da Buyin Wan and its derivatives. Da Buyin Wan (Major Replenish Yin Pills) has four ingredients: tortoise shell, cooked rehmannia, anemarrhena, and phellodendron. The herbs are powdered, combined with honey, and made into large boluses of 9 grams each. Dosage is one pill each time, two or three times per day. Each pill contains about 6 grams of herbs and 3 grams of honey, with just over 2 grams of tortoise shell per pill. This formula is used for replenishing the yin and calming upflaring of kidney fire (deficiency fire). Typical indications include fever and night sweating, restlessness, red tongue, thin tongue coating, and rapid pulse. Tortoise shell also addresses weakness, heaviness, and pain in the legs. One of the best-known derivatives of this formula is Huqian Wan (Pill of Hidden Tiger; referring to stealthy walking of the tiger). This is made by combining the four ingredients of Da Buyin Wan with cynamorium, tiger bone, peony, ginger, and citrus (produced as honey boluses in the same manner). Today, tiger bone is not used, but may be substituted by other bones that are readily available (e.g., pig bones). Like tortoise shells, bones are mainly comprised of collagen and calcium compounds (with emphasis on calcium phosphate). The incorporation of cynamorium and tiger bone (or its substitutes) is intended to focus the action of the formula on flaccidity of muscles and bones, weakness of the lower back and legs, and difficulty walking. As a result, this formula, and modifications made by adding even more tonic ingredients, such as Jianbu Huqian Wan (sometimes called Pill of Flying Feet; literally, Healthy Steps Stealthy Tiger Pills), have been applied in recent times for disorders that cause leg paralysis (such as multiple sclerosis and ALS). Another formula that is based on Da Buyin Wan is Heche Dazao Wan (Placenta Great Nourishing Pills), which replaces anemarrhena with ophiopogon and asparagus, and includes the tonic group ginseng, eucommia, placenta, and achyranthes to tonify qi and yang and nourish blood.
2. Yin deficiency without deficiency fire, accompanied by a slight deficiency of yang. Tortoise shell is combined with deer antler for this purpose, as occurs in Gui Lu Erxian Jiao (Tortoise-Antler Two Immortals Glue). In this case, the two gelatin-containing ingredients are combined with ginseng and lycium in the form of a powder; this is taken in doses of 3 grams each time with some boiled water. The formula nourishes yin (tortoise and lycium) and invigorates yang (ginseng and deer antler), and is used to treat weakness of the back and legs. Another example is Zuogui Wan (Left Returning Pill; that is, pill for restoring the yin to the left kidney). In this formula, the gelatin of tortoise shell and of deer antler is added to a modification of Rehmannia Six Formula (Liuwei Dihuang Wan) containing rehmannia, dioscorea, cornus, lycium, achyranthes (or cyathula, chuanniuxi), and cuscuta.
3. Yin and blood deficiency with stirring of internal wind. Tortoise shell is combined with peony and other liver nourishing agents and with oyster shell (alone or with other wind suppressing agents) for this purpose. Examples are Zhengan Xifeng Tang (Decoction to Rectify the Liver Function and Reduce Wind), which contains the yin and blood nourishing agents tortoise shell, peony, achyranthes, scrophularia, and asparagus to prevent development of wind due to liver deficiency, and the heavy sedating agents hematite, dragon bone, and oyster shell to suppress the rising wind. In addition, the formula contains malt, melia, and capillaris to regulate liver qi in order to avoid having the liver overly suppressed by the combination of rich tonics and heavy sedatives. Another such formula is Da Dingfeng Zhu (Big Pearl to Calm Wind), which combines the yin and blood nourishing agents tortoise shell, egg yolk, gelatin, peony, raw rehmannia, and ophiopogon with oyster shell to suppress wind. A third example is Sanjia Fumai Tang (Decoction of Three Shells to Recover the Pulse) which nourishes yin and blood using tortoise and turtle shells, gelatin, ophiopogon, peony, and raw rehmannia, with oyster shell to suppress wind. These formulas all have a cooling quality to help calm the agitation of the liver. For heart agitation associated with yin deficiency, tortoise shell is combined with dragon bone, as in Zhenzhong Dan, which is comprised of these two ingredients along with acorus and polygala to open the heart orifices. This will treat insomnia and irritability; similar formulations have been applied in modern times to treat attention deficit disorder with hyperactivity.
It will be noted here that nourishing yin and blood are the primary functions of these formulas, and that some of the other indications, such as treatment of bleeding and closure of fontanel, are not mentioned directly, as they are secondary applications.
Acknowledgment: Dr. Fu Kezhi, at the Harbin office of ITM, conducted a literature search and provided valuable background information for this article.

Dose: 9-30g

Gui Ban Jiao: Gui ban gelatin
• Same functions as Gui ban, but is richer, more cloying, stronger to nourish Yin, and stops bleeding.
• Beneficial for uterine bleeding due to kidney Qi deficiency.
• Dissolve in wine or a strained decoction.

Dose: 3-9g

Han Lian Cao – Mo Han Lian – Eclipta

Nature: sweet, sour, cold

Enters: Liver, Kidney

Actions: Cools the blood; stops bleeding; mildly nourishes kidney and liver Yin; sharpens the senses.

Indications:
• Kidney and liver Yin deficiency: dizziness, early greying of the hair, blurry vision, vertigo.
• Yin deficiency heat: hematemesis, hemafecia, epistaxis, uterine bleeding, coughing up blood, and especially hematuria.
• Beneficial for diphtheria.
• Topical: for hemorrhage.
• Similar in actions to Sheng di, but not greasy – a better choice when the patient has a digestive disorder.
Han lian cao’s function to nourish Yin is quite limited.
Hong-Yen Hsu (Oriental Materia Medica): Antibacterial, hemostatic, blood cooling, possibly anti-inflammatory.
Dui Yao (Sionneau): Nourishes the lower and upper parts; enriches Yin and blackens the hair.
• With Nu zhen zi to effectively supplement the liver and kidneys, cool the blood and stop bleeding, and blacken the hair. For the following indications, this combination, Er Zhi Wan, should be prepared with wine-steamed Nu zhen zi.
– 1. Liver-kidney deficiency heat.
– 2. Vertigo, dizziness, insomnia, and loss of memory due to liver-kidney deficiency with Yin and blood not nourishing the upper part of the body.
– 3. Premature greying of the hair and beard due to kidney essence deficiency.
– 4. Nosebleed, bleeding gums, hemoptysis, hematemesis, hematuria, and metrorrhagia due to Yin deficiency heat which forces the blood out of the vessels. Han lian cao’s action of cooling the blood and stopping bleeding is not very strong. The combination can be strengthened for these purposes by adding Sheng di, Mu dan pi, Ce bai ye, and Qian cao gen.

Dose: 9-15g (to 30g when fresh)

Hei Zhi Ma – Black Sesame seed

Nature: sweet, neutral

Enters: Liver, Kidney

Actions: Nourishes blood; supports Jing; moistens the large intestine, promotes bowel movement; extinguishes wind (due to blood deficiency).

Indications:
• Blood deficiency, body fluid deficiency, or Yin deficiency: constipation (good for the elderly).
• Blood and Jing deficiency: early greying of the hair, dizziness.
• Internal wind due to blood deficiency: headache, dizziness, numbness.
• This herb is only a weak tonic, but it has no side effects.
• Very rich in calcium.
• Sesame oil: excellent for massage, non-comedogenic, bacteriostatic.
Yoga of Herbs (Frawley and Lad): Tila: V-; P, K, or Ama + (in excess)
• Rejuvenative tonic for Vata.
Sattvic.
Hong-Yen Hsu (Oriental Materia Medica): Purgative, lowers blood sugar.

Dose: 9-30g

Huang Jing – Polygonatum sibiricum rhizome – Siberian Solomon’s Seal – “Yellow Essence”

Nature: sweet, neutral

Enters: Lung, Spleen, Kidney

Actions: Nourishes Lung Yin; tonifies spleen Qi, nourishes spleen Yin; mildly nourishes kidney Yin and Jing, generates marrow; relieves Xiao Ke (wasting and thirsting syndrome).

Indications:
• Lung Yin (and Qi) deficiency: dry cough; maybe streaks of blood in sputum; possible flushed cheeks and irritability to due heat.
• Kidney Jing deficiency: weakness and soreness in the lumbar region and knees, dizziness, weakness in the lower extremities, lightheadedness, blurred vision, prematurely grey hair.
• Spleen and stomach Qi deficiency: poor appetite, fatigue, weak pulse, lassitude.
• Spleen and stomach Yin deficiency: dry mouth, poor appetite, loss of taste, dry stool, dry, red tongue.
• Lung, stomach, and kidney Yin (and Qi) deficiency: diabetes / xiao ke / wasting and thirsting disorder (whether in upper, middle, or lower jiaos, or a combination): polyuria, polyphagia, polydipsia, emaciation, irritability, fatigue.
• Very safe, will not trap an EPI in the body, not greasy. Liu: “Typical Taoist herb.”
• Can be taken long-term.
• May lower blood pressure.
• Beneficial in tuberculosis.
• Adaptogenic effects.
• Topical (alcohol tincture) for fungal infections.
• The raw form (less used) is more of a Yin tonic than a Qi tonic.
• The prepared form (common), which is wine-steamed, is more of a Qi tonic than a Yin tonic.
• Bensky/Gamble classify this herb as a Qi tonic.
• Michael Tierra compares this herb, rather than Yu zhu, to American Solomon’s Seal (an error?), and considers American Polygonatum to be as good or better than the Chinese variety.
Dr. Wei Li (Portland, Oregon): Good non-warming immune tonic.
Chinese Medical Herbology & Pharmacology: “The ideal herb to treat yin-deficient cough, nourish the lung, and benefit Qi. In combination with other herbs or alone.”
Oriental Materia Medica (Hong-Yen Hsu): Antifungal, antibacterial, hypotensive, hypoglycemiant.
Heiner Fruehauf: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).

Dose: 6-18g

Luo Han Guo – Momordica fruit – “Arhat Fruit”

Nature: sweet, neutral

Enters: Lung, Spleen

Actions: Moistens and cool the Lungs; dissipate nodules.

Indications:
• Hot coughs, especially in cases of Lung Yin deficiency.
• Phlegm nodules in the neck, such as scrofula.
• Recently used as the source of a low-calorie sweetener.
Hong-Yen Hsu (Oriental Materia Medica): Diuretic, vasodilator – coronary and renal; strengthens capillaries, anti-inflammatory.

Dose: 9-15g (½ to 2 pieces of fruit)

Luo Han Ye: Momordica leaf
• Similar to the fruit.
• Chronic throat problems, chronic bronchitis.

Mai Men Dong – Mai Dong – Ophiopogon tuber – “Lush Winter Wheat”

Nature: sweet, slightly bitter, slightly cold

Enters: Lung, Heart, Stomach

Actions: Nourishes Yin; moistens the Lungs, stops coughing; generates Yin and body fluids for the stomach; clears heat from the heart to ease restlessness; moistens the intestines.

Indications:
• Lung heat and Yin deficiency: dry cough, thick, difficult to expectorate sputum, coughing up blood.
• Stomach Yin deficiency: dry mouth, thirst.
• Heart heat and Yin deficiency or ying-level febrile disease: restlessness, insomnia, irritability, worse at night.
• Yin deficiency or aftermath of a febrile disease: constipation, dry mouth, irritability.
• Can reach the upper and middle Jiaos.
• May lower blood sugar.
• For Lung heat and dryness, compared to Tian hua fen and Tian men dong, Mai men dong is best when the origin is heart fire (Tian hua fen is best when the origin is stomach heat and Tian men dong is best when the origin is kidney Yin deficiency)
• Frying the herb in wine reduces its cold properties, which is indicated when the herb is used in tonic formulas.
Dui Yao (Sionneau): Compared to Tian men dong, Mai men dong is better for Lung/stomach Yin deficiency, and better for nourishing the heart and quieting the spirit.
Hong-Yen Hsu (Oriental Materia Medica): Antipyretic, antitussive, expectorant, cardiotonic, diuretic, hypoglycemiant, antibacterial, may have anti-inflammatory properties.

Dose: 6-15g

Nu Zhen Zi – Ligustrum seed – Privet fruit – “Female Chastity Seed”

Nature: sweet, bitter, cool

Enters: Liver, Kidney

Actions: Nourishes kidney and liver Yin; clears liver heat; improves vision; clears Yin deficiency heat.

Indications:
• Kidney and liver Yin deficiency: dizziness, weak lumbar region and knees, premature aging, early greying of the hair, diminished visual acuity, blurry vision, tinnitus.
• Yin deficiency heat: fever.
• As a tonifying seed, this herb is sometimes thought of as promoting fertility.
• No greasy side effects – good for Yin deficient patients with poor digestion.
• This herb is not a powerful Yin tonic.
• Doctrine of signatures: black and shaped like a kidney – nourishes the kidneys.
Journal of Traditional Chinese Medicine: Lowers serum cholesterol; improves blood supply to the heart.
• Acne: may help by regulating endocrine function.
• Lowers blood sugar.
• Treats cirrhosis of the liver.
• Hyperthyroidism.
• Brown spots on the skin.
Michael & Leslie Tierra: Immune tonic to counter effects of radiation and chemotherapy.
Hong-Yen Hsu (Oriental Materia Medica): Cardiotonic, purgative, nutritive, may inhibit tumor growth.
Dui Yao (Sionneau): With Han lian cao to effectively supplement the liver and kidneys, cool the blood and stop bleeding, and blacken the hair. See Han lian cao in this category for specific indications and notes on this combination.

Dose: 4.5-15g

Sang Ji Sheng – Mistletoe (parasitizing Morus) – Viscum/Taxillus or Loranthus – “Mulberry Parasite”

Nature: bitter, neutral

Enters: Liver, Kidney

Actions: Tonifies the liver and kidneys; strengthens the tendons and bones; expels wind and dampness; nourishes blood; calms the fetus/womb; benefits the skin.

Indications:
• Liver and kidney Yin deficiency (with or without wind-damp): soreness and pain in the lower back and knees, joint problems, numbness, weakness and atrophy of the sinews and bones.
• Wind-dampness: Bi syndrome with some lumbar region and knees.
• Restless fetus, uterine bleeding, threatened miscarriage in pregnancy.
• Blood deficiency: dry, scaly skin.
• Hypertension.
• Diuretic component.
• Wine-fry the herb to strengthen its ability to expel wind-dampness.
Dr. Wei Li (Portland, Oregon): Drunk alone as tea by elderly in China, “Tonifies everything.”
Michael & Leslie Tierra: Versatile for back and joint pains, stiffness from various causes, especially for those who develop gradual stiffness and aching pain of the lower back with difficulty bending at waist.
Hong-Yen Hsu (Oriental Materia Medica): Lowers serum cholesterol, diuretic, antibacterial, pronounced antiviral.
Rudolf Weiss (Herbal Medicine): (host not specified)
• Hypertension: parasympathetic stimulant, vasodilator.
Definite benefit in hypertension, however, “oral use cannot provide effective treatment for arterial hypertension, nor can too much be expected as regards reduction in blood pressure, and certainly no lasting effect… yet practitioners and patients repeatedly find it has excellent subjective effects on headaches, dizziness, loss of energy, irritability and other symptoms connected with hypertension…” No unpleasant side effects, non-toxic in usual dosage, gentle, good for extended treatment of slightly or moderately raised blood pressure, which will go down in the course of treatment. Ideal treatment for blood pressure of about 160/100. Best prepared as a cold water extract: pour 1/4 liter cold water over 2-4 teaspoons chopped herb, let stand overnight and drink in morning. prepare another cup to be drunk at night.
Patients are very fond of this three herb blend: equal parts mistletoe, (Western) hawthorn flowers and leaves (to improve coronary circulation), melissa (lemon balm) leaves (as a cardiac sedative). Take 1 cup morning and night, prepared by infusing 2 teaspoons of the mixture for 5-10 minutes, taken in sips while still warm. May be sweetened with honey.
• Cancer: extensive literature available on commercial extracts (e.g. Iscador). Unlike cytostatic drugs, mistletoe extracts are non-toxic, well tolerated. Reported to reduce tumor size and improve patients’ general condition. Used mainly after surgery and radiation.
• Arthritis: mistletoe preparations (e.g. Plenosol) are injected into the joint.
PCBDP: Cardiac tonic; antineoplastic (binds to DNA, inhibits protein synthesis).
For various cancers (including lung, ovary).
JC: Nervine, antispasmodic, tonic, slight narcotic, diuretic, emmenagogue, emetic.
• Used in all problems caused by weakness of or a disordered state of the nervous system. Quiets, soothes, and tones the nerves, lessens cerebral excitement, helps febrile conditions.
• Useful in weakness of female generative organs, incites uterine contractions.
• Gives tone in cardiac affections. possesses non-injurious properties.
• For hysteria, epilepsy, uterine hemorrhages, amenorrhea, dysmenorrhea, heart troubles (especially in typhoid fever), hypertension, convulsions, delirium, nervous debility, fits, nervousness, chorea (St. Vitus’ Dance), cardiac edema, cholera.

Dose: 9-60g

Sang Shen – Morus fruit – Mulberry

Nature: sweet, cold

Enters: Heart, Liver, Kidney

Actions: Nourishes blood and Yin; generates body fluids; moistens the large intestine.

Indications:
• Heart, liver, and kidney Yin/blood deficiency: dizziness, diminished vision, tinnitus, insomnia, premature greying of hair.
• Injury of body fluids: thirst.
• Yin and blood deficiency: constipation with dry stool (good for the elderly).
• Yin deficiency: wasting and thirsting disorder.
• Use prepared form for blood deficiency.
• Bensky/Gamble categorize this herb as a blood tonic.

Dose: 6-15g

Sha Shen – Bei Sha Shen – Glehnia root – “Sand Root”

Nature: sweet, bland, slightly cold

Enters: Lung, Stomach

Actions: Clears heat; nourishes Lung Yin; produces body fluids for the stomach; moistens the Lung and stops coughing; moistens the exterior.

Indications:
• Lung heat with Yin deficiency: dry, nonproductive or bloody cough, hoarseness.
• Stomach body fluid injury due to heat in febrile disease: poor appetite, dry mouth and throat, thirst, accompanying constipation.
• Dry itchy skin, especially when worse with cold, dry weather.
• A key herb for Lung and stomach Yin deficiency.
Sha shen usually implies Bei sha shen.
Dr. Wei Li (Portland, OR) Good for depression. Nourishes spleen Yin so it can fight off attack by the liver.
Hong-Yen Hsu (Oriental Materia Medica): Antipyretic, analgesic (ethanol extract), slight expectorant.
Michael & Leslie Tierra: Nearly the same as Xi yang shen, but cheaper.
Heiner Fruehauf: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).

Dose: 9-15g

Nan sha shen – Adenophora:

This herb is also called Sha shen, although it is somewhat less common. It is weaker at nourishing Yin and Qi than Bei Shan Shen is, and unlike Bei Sha Shen, it does not generate fluids, but it is better than Bei sha shen at stopping coughs.

Shi Hu – Dendrobium – “Bushel of Stone” (also the substitute, Ephemerantha)

Nature: sweet, slightly cold

Enters: Stomach, Kidney

Actions: Generates body fluids for the stomach; nourishes stomach Yin, mildly nourishes kidney Yin; clears heat; brightens the vision; strengthens the lower back, tendons, and bones.

Indications:
• Stomach Yin deficiency or injury of stomach body fluids by heat: dry mouth, thirst, stomach ache, dry heaves, shiny tongue, intractable fever, wasting and thirsting disorder, constipation.
• Kidney Yin deficiency: prolonged low grade fever (do not count on Shi hu alone in cases of kidney Yin deficiency), blurred vision, dizziness; pain, soreness, weakness of the back and knees; numbness of the extremities or wei syndrome (in appropriate combination).
• Febrile disorders with injured Yin.
• Can trap an EPI in the body and prolong the sickness. If there is a chance of EPI, Mai men dong or Yu zhu is a better choice.
• Premier herb for stomach Yin deficiency: stronger than Mai men dong at nourishing stomach Yin.
• The true herb is effective at lowering blood pressure, even in small doses. Treasured and consumed by elderly, often even saving the cooked herb and chewing on it to get all the medicine out of it.
• The true herb is quite difficult to obtain in the U.S., and is very expensive, though it is also very popular with some practitioners.
Hong-Yen Hsu (Oriental Materia Medica): Stimulates smooth muscle contraction of the small intestine, increases its tonicity, promotes peristalsis and gastric secretion.
• Slightly antipyretic and analgesic.
Eric Brand: Shi Hu is a yin-supplementing medicinal that is sold in many different grades and qualities. True Shi Hu refers to dendrobium orchid, but in actuality most of what is used as Shi Hu on the market is a tolerated substitute rather than true dendrobium. The substitute pictured above is an authentic medicinal, but it is considered a less expensive and less effective form of Shi Hu. True Shi Hu and its substitute (which is properly called “You Gua Shi Hu,” derived from Ephemerantha fimbriata (Bl.) P.E. Hunt et Summ) are both in the orchid family, but they are from plants in different genera that have significantly different appearances. Generally speaking, the two should be differentiated in trade and in clinical use.
The true Shi Hu seen on the market is almost always cultivated. Wild Shi Hu is endangered and is protected under CITES law, so trade is only permitted if a certificate of cultivation is provided. It is common to see products on the Chinese wholesale market or the Chinatown market that are sold as “wild” Shi Hu, but these products are nearly always cultivated and are not truly wild. Generally true Shi Hu is sold in thin, long (or cut) pieces or rolled bundles. The rolls can be large or small, and different subtypes of the medicinal have stems of varying thickness. High quality Shi Hu can be quite expensive.
To test the quality of true Shi Hu, chew it. As you chew, pay attention to the flavor and texture. The more fibrous it is, the more average the quality is. The more sticky and soft it is, the better it is. The good stuff is sticky and slightly sweet when chewed, but it needs to be chewed slowly and held in the mouth to get the full effect. True Shi Hu and You Gua Shi Hu can be differentiated from each other at a glance, but the different grades of true Shi Hu require the test of chewing to fully assess their quality.
Shi Hu is very popular in Japan, Taiwan, and Hong Kong. The Chinese medicine culture in Southern China (Canton, Hong Kong, etc) tends to favor cooling, yin-supplementing agents like Shi Hu, so the South is the place to see a lot of it. The area around Hangzhou is also a major production region for Shi Hu, so it is popular there as well. Shi Hu is often grown in greenhouses and can be grown hydroponically. The best quality tends to go to the Japan, Taiwan, and Hong Kong markets, and premium quality Shi Hu is grossly overpriced in the U.S. As a general rule, don’t believe vendors that try to tell you that the product is wild, because the wild product is truly rare and insanely expensive.
Good quality Shi Hu is a beautiful thing, and I feel that Shi Hu is underappreciated in the Western TCM world. As I mentioned before in my blog about Chuan Bei Mu, any herb that gets the attention and respect of an entire cultural region is worth looking into. Shi Hu has an incredibly developed niche in East Asian culture and it is a special medicinal that deserves more attention.

Dose: 6-15g

Tian Men Dong – Asparagus tuber – “Lush Winter Aerial Plant”

Nature: sweet, bitter, very cold

Enters: Lung, Kidney

Actions: Clears heat and reduces fire from the Lungs; nourishes Lung and kidney Yin; moistens dryness, intestines.

Indications:
• Lung heat or fire and Yin deficiency: dry cough with small amount of sticky sputum or cough with bleeding.
• Injury of Yin by heat: dry mouth and thirst.
• Lung and kidney Yin deficiency: wasting and thirsting disorder, consumption, low-grade afternoon fever.
• Large intestine dryness: constipation.
• Sore throat due to kidney Yin deficiency fire or lung heat.
• Reaches the upper and lower Jiaos.
• Often used with Mai men dong to treat both the mother and son.
• Has a viscous, cloying nature – can easily produce stagnation.
• Antibiotic effects.
• May help leukemia.
• Said to engender love and compassion.
• For Lung heat and dryness, compared to Tian hua fen and Mai men dong, Tian men dong is superior when the origin is kidney Yin deficiency (Tian hua fen is best when the origin in stomach heat and Mai men dong is best when the origin is heart fire)
Dui Yao: The Art of Combining Chinese Medicinals: Compared to Mai men dong, Tian men dong is better for Lung/kidney Yin deficiency, and better for clearing and moistening.
The Yoga of Herbs: An Ayurvedic Guide to Herbal Medicine: Shatavari: “who possesses 100 husbands” – named such because it is so tonic and rejuvenative to the female reproductive organs.
• P, V-; K and ama+ (in excess); Sattvic.
• Sexual debility, especially of the female organs, infertility, impotence, menopause, diarrhea, dysentery, stomach ulcers, hyperacidity, dehydration, lung abscess, hematemesis, cough, convalescence, cancer, herpes, leukorrhea, chronic fevers.
• A rasayan for Pitta, for the female reproductive system, and for the blood.
• Demulcent for dry and inflamed membranes.
• Topical: emollient for stiff joints, neck, muscle spasm.
• Contains many female hormones.
Potter’s New Cyclopaedia of Botanical Drugs and Preparations: Diuretic, laxative, cardiac tonic and sedative.
• Also for neuritis and rheumatism.
Oriental Materia Medica (Hong-Yen Hsu): Antibacterial, antitussive, diuretic, laxative.
Chinese Medical Herbology & Pharmacology: May increase milk production in nursing mothers.
• With Bai Hua She She Cao (oral, injected) for malignant lymphoma, breast cancer, fibrocystic breasts.

Dose: 6-15g

Xi Yang Shen – American Ginseng – Panax quinquefolium – “Western Seas Root”

Nature: bitter, sweet, cold

Enters: Heart, Lung, Kidney

Actions: Nourishes Yin; tonifies Qi; clears heat/fire; generates body fluids.

Indications:
• Lung Yin deficiency fire: difficulty breathing, cough with sputum and blood, loss of voice, wheezing.
• Injury of Lung and stomach Yin and Qi: fatigue, thirst.
• Yin deficiency: dry mouth and tongue, chronic unabating fever.
• Aftermath of febrile disease: weakness, irritability, thirst.
• Good for tuberculosis.
• Good for patients with heat and Qi/yin deficiency.
• Much weaker than Ren shen at nourishing Qi.
• Not to be combined with Li lu.
• Do not cook this herb in an iron pot. Often cooked separately from other herbs in a double boiler.
HF: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).

Dose: 2.4-9g

Notes on This Category

• These herbs are generally contraindicated in cases of hyperactive Yin deficiency fire. Most are contraindicated when an excess, exterior, or heat condition exists. Compared to the category of herbs that warm the interior, Yang tonics are mostly sweet, many slightly nourish Yin, and most are slower acting than the interior-warming herbs to activate Yang. Herbs that warm the interior may be used for excess cold, can restore collapsed Yang, are mostly hot and acrid, and mainly activate but do not so much tonify Yang.
• Yang tonics are often combined with a small amount Yin nourishing herbs to give the Yang some substance to “cook” or “cling to.” (The formula Jin Gui Shen Qi Wan is a good example of this principle, though it utilizes Interior Warming herbs [Fu Zi, Rou Gui] instead of Yang tonics.)

Ba Ji Tian – Morinda root

Nature: acrid, sweet, slightly warm

Enters: Kidney, Liver

Actions: Tonifies kidney Yang (without blocking Qi); eliminates wind-damp (including in the bones); strengthens sinews and bones.

Indications:
• Kidney Yang deficiency: impotence, frequent urination, infertility (male or female), irregular menses, premature ejaculation, urinary incontinence, cold and pain in the lower abdomen, weak and sore lower back, muscular atrophy.
• Kidney Yang deficiency plus attack of wind-damp: weakness or pain in the lumbar region, knees, backs of the legs; bony Bi.
• Best used for cases of Yang deficiency with cold-damp.
Hong-Yen Hsu (Oriental Materia Medica): Antibacterial, hypotensive, has effects resembling those of cortical hormones.
Weng Weiliang, et. al.:
Aspermia:
Xing Yang Sheng Jing Dan (experiential formula): ba ji tian, ying yang huo, tu si zi, gou qi, yu biao jiao, testicles of goat, male silkworm moth, placenta, rou cong rong, jiu cai zi were made into pills, 10g, bid, three months as a course of treatment. 25 cases were treated, 20 were effective.
Impotence:
Xing Yang Chong Ji (experiential formula): chai gou shen, yin yang huo, ba ji tian, shan yu rou, chai hu, dang gui, bai shao, lu jiao jiao and gou qi were made into granules, 12g per bag, 1 bag, tid. 50 patients were treated and 43 were effective.

Dose: 6-15g

Bu Gu Zhi – Psoralea fruit – “Tonify Bone Resin”

Nature: acrid, bitter, very warm

Enters: Kidney, Spleen

Actions: Tonifies kidney Yang; controls Jing and urine; tonifies and warms spleen Yang, stops diarrhea; helps the kidneys grasp the Lung Qi.

Indications:
• Kidney Yang deficiency: impotence, cold and pain in the lumbar region and knees, weak lower back and extremities, premature ejaculation; frequent urination, urinary incontinence, enuresis, nocturnal emissions without dreams.
• Spleen Yang deficiency (usually with kidney Yang deficiency): severe, chronic diarrhea, borborygmus, abdominal pain.
• Kidneys fail to grasp the Lung Qi: wheezing.
• This herb can be hard on the stomach, but is still sometimes used cautiously for cold deficiency of the stomach.
• Topical: alopecia, psoriasis, vitiligo (especially in combination with UV light), fungus. Caution with sun/UV exposure with this herb on the skin – increases risk of sunburn.
• May dilate coronary vessels.
• With Chi shi zhi, it can stop menorrhagia.
Bu gu zhi’s kidney-tonifying properties are more pronounced than its spleen-warming qualities. The opposite is the case with Yi zhi ren.
• Topical vitiligo formula: in a base of coconut oil, extract on low heat: Bu gu zhi, barberry root bark (Western herb), and nigella (black cumin) seed (or just add cold pressed nigella seed oil to this formula).
• Crush before using.
Dr. Hong Jin (Oregon College of Oriental Medicine) Modern research shows hormonal (estrogen-like) effects.
• Uses in acne formula.
Dui Yao (Sionneau): Strengthens true Yang; warms the cinnabar field.
• With Hu tao ren to supplement metal and water, to effectively constrain the Lung Qi and promote the intake of Qi by the kidneys, stop cough, and calm asthma. For the following indications, salt-processed Bu gu zhi should be used:
– 1. Cough, dyspnea, and asthma due to kidney Yang deficiency.
– 2. Lumbago, impotence, seminal emission, constipation, frequent and abundant urination, and enuresis due to kidney Qi deficiency.
• With Rou dou kou to supplement spleen and kidney Yang, secure the intestines, and stop daybreak or “cock-crow” diarrhea. For indications such as:
– 1. Chronic diarrhea due to spleen-kidney Yang deficiency. (Si Shen Wan) Use salt mix-fried Bu gu zhi and roasted Rou dou kou.
– 2. Daybreak diarrhea with abdominal pain and rumbling noises due to spleen-kidney Yang deficiency. (Er Shen Wan)
Bu gu zhi is incompatible with pork blood.
Hong-Yen Hsu (Oriental Materia Medica): Dilates coronary arteries, stimulates the heart, increases rate and function.
• Antibacterial (tuberculosis).
• External use promotes production of melanin – used to treat calluses and warts.
• May have anti-cancer effects – inhibits artificially-induced tumors.
• Therapeutic action against Tinea versicolor and psoriasis.

Dose: 3-9g

Dong Chong Xia Cao – Cordyceps mushroom (and, traditionally, the carcass of the caterpillar it parasitized) – “Winter Bug Summer Herb”

Nature: sweet, warm

Enters: Kidney, Lung

Actions: Tonifies Lung Yin and kidney Yang; stops bleeding; resolves phlegm.

Indications:
• Kidney Yang deficiency: impotence, seminal emission, weak and sore lumbar region, knees, and lower extremities.
• Lung Yin deficiency: asthma and cough with bleeding, chronic bronchitis, pulmonary tuberculosis, consumptive cough with blood-streaked sputum.
• Because it tonifies both Yin and Yang and is a very safe substance, it can be taken over a long period of time.
• Often cooked with duck (or other meats) for a stronger tonic effect.
• Doctrine of signatures: for impotence – this mushroom (after invading the insect’s body with its mycelia) bursts forth from the caterpillar’s head.
• Different species of cordyceps fungi parasitize hundreds of different insects and also decaying wood. Dong chong xia cao is specifically the species that grows on the caterpillar or pupa Hepialus varians. The whole caterpillar-mushroom combination is very expensive. High quality, more affordable lab-grown fungus is now widely used.
Oriental Materia Medica (Hong-Yen Hsu): Bronchodilator, sedative, antibacterial, antifungal.
Eric Brand on wild vs cultivated cordyceps.
Weng Weiliang, et. al.:
Cardiovascular diseases:
• Shao Geng et al. carried out clinical research on the effects of treating hyperlipemia with cultured Cordyceps (Jin Shui Bao, a product made from cultured Cordyceps) with double-blind comparison method. 273 cases were equally divided into treated group and control group approximately. After 1~2 months’ treatment, in the treated group, the average of serum total cholesterol was lowered by 17.5% compared with that before the treatment (the control group lowered by 1.2%); triglyceride was lowered by 9.9% (the control group 6.7%); high-density lipoprotein cholesterol (HDL-C) was increased by 27.2% (the control group increased by 10.4%). Compared with the control group, the differences were statistically significant. Accordingly, it’s believed that this drug had reliable cholesterol-reducing as well as HDL-C increasing function.
• Arrhythmia was treated with Ning Xing Bao (a product made from Cordyceps) by Li Peizhang et al. and with Xing Gan Bao (a product made from different fermented Cordyceps) by affiliated hospital of Guangzhou medical college. 200 cases were reported by the former author, the total effective ate was 74.5%; while 188 cases were reported by the latter author, the total effective rate was 74.4%~79.6%.
• You Jingen used P.sinensis to treat 33 cases of coronary heart disease. The markedly effective rate of angina pectoris was 52.4%; and the effective rate of EKG was 42.4. Accordingly, it’s believed that the effect of P.sinensis came up to that of persantine.
Respiratory diseases:
• Six hospitals were organized by Jiangxi TCM factory to make the research on the effects of treating chronic bronchitis with Jin Shui Bao (a product made from Cordyceps). Results: after one month’s administration, among the 117 cases that took Jin Shui Bao, 58 cases were markedly effective (the markedly effective rate was 49.6%), 39 improved (33.3%), the total effective rate was 82.9%; among the 77 cases that took Mu Jing Oil, the markedly effective rate was 9%, and the total effective rate was 40.2%.
• Fu Fang Chong Cao (Cordyceps) Ge Jie (gecko) San was used to prevent asthma attack in 68 patients. There’re 42 males and 26 females, 35 of them had courses of diseases between 1~5 years, the other 33 cases were over 5 years. The ingredients: ge jie, one pair; Cordyceps, 5g; zi he che, huang qin, hou po, bai jie zi, 15g each; chen dan xing, 10g, huang qi, 30g. The drugs were ground into powder. For patients without symptoms, the dosage was 0.5~1g, tid; for those with symptoms of mild cough or asthma, the dosage was 1.5g tid. The patients took the treatment from later October to early April of next year, for two years. Results: within the two years, 36 cases didn’t have asthma attacks, and were markedly effective; the other cases were effective.
Sexual disorders:
• Yang Wenzhi et al. carried out clinical research on treating low sexual function with Jin Shui Bao (a product made from Cordyceps). They compared the effects of Jin Shui Bao, natural Cordyceps and placebo with method of single-blind comparison and sequential administration. Methods: dosage 1g every time, three times daily, 20 days as a course; take the medicine according to the order of Jin Sui Bao, placebo and natural Cordyceps. Results: 16 cases totally, 9 were markedly effective when given Jin Shui Bao (56.2%), only 1 markedly effective when given placebo, and 4 markedly effective when given natural Cordyceps (25%).
• Deng Xiaoan analysized 272 cases of low sexual function (11 were female), 152 cases were treated with Jin Shui Bao (a product made from Cordyceps). After 40 days’ administration, the effective rate was 66.1%. Among 23 cases treated with natural Cordyceps, the effective rate was 31.6%. In the 97 cases of control group, the effective rate was 23.7%.
Renal diseases:
• Chen Yiping et al. reported the effects of treating 30 cases of chronic renal failure with Jin Shui Bao (a product made from Cordyceps). After one month’s treatment, the patients’ renal function was improved significantly, which was manifested as obviously decreased creatinine and urea nitrogen in the blood compared with those before treatment, increased creatinine clearance and hemoglobin. Natural Cordyceps and other cultured Cordyceps preparation (Zhi Ling Capsule) had certain effects too. Shen Lingmei treated 18 cases of chronic nephritis with cultured Cordyceps, it was observed that the renal function was improved and urine protein decreased obviously.
Hepatic diseases:
• According the report of Zheng Furong, in Shanghai and some other areas, cultured Cordyceps preparation Xing Gan Bao was used to treat 256 cases of chronic viral hepatitis, the effective rate was over 80%, most patients symptoms, signs and liver function were improved to various degree, and the changes of serum albumin and sGPT were the most obvious. Zhou Liangmei used cultured Cordyceps to treat 33 cases of chronic hepatitis B, among the 32 cases with abnormal TTT, after 3 months’ administration, 10 cases returned to normal, 13 cases were improved significantly. Liu Cheng et al. used cultured Cordyceps to treat 22 cases of posthepatitic cirrhosis, after 3 months’ treatment, albumin increased; among 17 patients suffering from abdominal distension, 12 cases’ ascites disappeared, and 5 cases’ ascites decreased.
• Ma Xiong, et al did some research on Cordyceps polysaccharides (CP) in order to evaluate its therapeutic effects in chronic hepatitis C. Twenty-one patients with chronic hepatitis C were treated with CP (15ml, t.i.d, taken orally) for 3 months. Peripheral blood CD3, CD4, CD8, NK activity and serum HA etc. were tested before and after the treatment. The results showed that the serum levels of ALT and r-GT were lowered after the treatment (P<0.05). HA, PIIIP were lower (P Tumors:
• Cheng Jianhua reported the effects of treating 20 cases of lung cancer in late period with Jin Shui Bao (a product made from Cordyceps) as an auxiliary therapy. There’s also a control group with WBC-elevating drugs as the auxiliary therapy. Results: 95% of the cases in the Jin Shui Bao group completed the radiotherapy or chemotherapy, 85% of the cases had a normal blood picture, both were significantly higher than those of the control group (which were 64% and 59% respectively). Yan Rujie et al. treated 50 cases of lung cancer in late period (4 cases were complicated with radiotherapy or chemotherapy). Results: after 2~4 months’ treatment, most of patients’ subjective symptoms were obviously improved, focus of infection of 23 cases (46%) decreased by more than 25%. Zhang Jinchuan treated 30 cases of 30 cases of malignant tumors with the auxiliary therapy consisting of Zhi Ling Capsule, results: symptoms of 93% of the cases were improved, and the WBC was elevated obviously.
• Jinshuibao Capsule (JSBC), produced by Jiangxi Jinshuibao pharmaceutical Company Limited, possesses the similar active principles and pharmacological activity with those of Cordyceps sinensis. The effect of JSBC on the immunological function of 36 patients with advanced cancer showed that it could restore cellular immunological function, improve quality of life, but had no significant effect on humoral immunological function. The results suggested that JSBC could be used as adjuvant drug in advanced cancer.
• Others:
• Chen Daoming et al. reported that 30 cases of primary thrombocytopenic purpura were treated with cultured Cordyceps, after three months, patients’ subjective symptoms and bleeding condition were improved significantly, the total effective rate was 90%. Chai Weimin et al. reported that Xin Gan Bao (a product made from Cordyceps) was used to treat 20 cases of schistosomiasis of ascites type in late period, after 3 months, all symptoms were improved: abdomen circumference and the spleen decreased, the diameters of the portal vein and the splenic vein decreased too. Besides, Liu Weisheng et al. used Xin Gan Bao (a product made from Cordyceps) to treat patients with decreased hemoglobin, decreased platelet or aplastic anemia, Zhang Jinmei et al. used Cordyceps to treat allergic rhinitis and tinnitus, and better effects were obtained in these treatment.
Examine.com: In vitro, Cordycepin appears to induce apoptosis and reduce proliferation of breast cancer cells (MCF-7 and MDA-MB-231) with an approximate IC50 of 100uM.[31] Despite influencing both cell lines, the mechanisms appeared to differ.
In estrogen non-responsive cells (MDA-MB-231), Cordycepin appears to induce DNA fragmentation in a time and concentration dependent manner resulting in apoptosis. This appeared to be related to a release of cytochrome c from the mitochondria to the cytoplasm associated with caspase activation and PARP cleavage.[31] An aqueous extract of Coryceps per se shares these apoptotic effects associated with mitochondrial membrane depolarization, and aside from acting via Akt inhibition it is augmented with inhibition of PI3K/Akt in vitro.[32] Only one other study has noted anti-proliferative effects on this cell line, but was highly confounded with other Bioactive Mushrooms.[33]
In MCF-7 cells, the death of cells appeared to be autophagic.[31] Cordycepin failed to induce DNA fragmentation but 200uM clearly induced autophagic vacuoles and associated with conversion of LC3-I to LC3-II, commonly thought to be a biomarker for autophagy.[34] The exact mechanism was not elucidated but was independent of the estrogen receptors.[31] Beyond apoptotic, the ethanolic acetate fraction of Cordyceps (Mycelium) in general appears to have anti-proliferative effects on MCF-7 cells with an IC50 value of 44.7ug/mL (Petroleum 87.37+/-1.61ug/mL, ethanolic 79.57+/-2.68ug/mL, water ineffective).[10]
Another component, Cordymin (peptide) also appears to inhibit MCF-7 breast cancer proliferation in concentrations up to 5mg/mL but not surpassing 50% inhibition;[13] biological significance of this is unknown due to the large molecular weight (10,906Da) and being a long polypeptide possible not absorbed in vivo. Another peptide (12kDa) was able to induce cytotoxicity in MCF-7 cells and reduce their viability to 33.41+/-3.81% of control at 15uM with an IC50 of 9.3µM in vitro.[14]
Finally, in the highly invasive 4T1 cell line an injected water soluble extract of Cordyceps (10-50mg/kg) significantly inhibited metastasis as measured in the lung (when the tumors were injected into the breast of rodents) without significantly affecting tumor size whatsoever.[35] This study hypothesized that the immunostimulatory properties of Cordyceps on macrophages attenuated the rate of which 4T1 cells progressed from G0 /G1 to GM phase, which was demonstrated in vitro.[35]
Conclusion: A variety of compounds that could benefit breast cancer by reducing proliferation of cells or induce cancer cell death, but none of these mechanisms are currently established in living models or compared against active control drugs (to assess potency)

Dose: 4.5-12g

 

Jin Chan Hua: Cordyceps sobolifera – Cordyceps growing on Cicada.
• Tonifies Lungs, improves vision.
• Kamto Lee: Specific guiding herb for lung cancer.

Du Zhong – Eucommia bark

Nature: sweet, warm

Enters: Liver, Kidney

Actions: Tonifies the kidneys and liver, strengthens tendons and bones; holds and calms the fetus; promotes smooth circulation of Qi and blood.

Indications:
• Kidney and liver deficiency: weak, sore lumbar region and knees, Wei syndrome, fatigue, frequent urination.
• Kidney and liver deficiency: threatened or habitual miscarriage, restless fetus; cold deficient kidney patterns with bleeding during pregnancy.
• Liver/kidney Yang deficiency cold: impotence, frequent urination.
• Lowers blood pressure: for hypertension, dizziness, lightheadedness from liver Yang rising.
• Compared to Xu duan, Du zhong is more effective when the problem is due primarily to deficiency, while Xu duan is used more to treat lower back pain with significant aspects of both wind-damp and kidney deficiency.
• Fry in salt water to increase kidney-tonification properties.
Hong-Yen Hsu (Oriental Materia Medica): Hypotensive – the fried herb is more potent, and the decoction is better than the tincture.
• Analgesic.
• Can decrease absorption of cholesterol.
Dui Yao (Sionneau & Flaws): Secures the Chong Mai.
• The major herb to treat lumbar pain. Can be used for all types – excess or deficiency, hot or cold – when combined appropriately with other herbs.
• With Xu duan for mutual reinforcement, to supplement the liver and kidneys, strengthen the sinews and bones, stop metrorraghia during pregnancy, and quiet the fetus. For indication such as:
– 1. Aches and pains, stiffness, lumbar pain, and weakness of the lower limbs due to kidney-liver deficiency. (Du Zhong Wan) Salt mix-fry both herbs.
– 2. Knee and lumbar pain due to wind-dampness.
– 3. Metrorrhagia during pregnancy and threatened miscarriage accompanied by lumbar pains due to kidney deficiency. (Salt mix-fry both herbs.)
– 4. Traumatic lumbar pain. (Qian Jin Bao Yun Dan) Use salt mix-fried Du zhong and wine mix-fried Xu duan.
Du zhong is more powerful than Xu duan at supplementing the liver and kidneys, strengthening the sinews, bones, and lumbar area. But Xu duan promotes circulation within the vessels, dispels blood stasis, and knits together fractured bones and torn ligaments.

Dose: 6-15g

E Guan Shi – Tubular Stalactite tip – “Goose Neck Stone”

Nature: sweet, warm

Enters: Lung

Actions: Strengthens Yang; transforms phlegm; descends Qi; benefits Qi; promotes lactation.

Indications:
• Yang deficiency with phlegm: cough and wheezing, emphysema.
• Insufficient lactation.
• Doctrine of signatures: its ability to direct Qi downward is indicated by its consistent downward growth.
• Crush or powder before use.
• Excessive or prolonged use can stagnate stomach Qi.
• Bensky/Gamble: In most cases this herb is fossilized Balanophylla species (coral).
• Contraindicated in cases of wheezing with blood.
• Cook 30 minutes longer than other herbs.

Dose: 9-30g

Ge Jie – Gecko

Nature: salty, neutral

Enters: Kidney, Lung

Actions: Tonifies Lung Qi and kidney Yang; nourishes Jing and blood.

Indications:
• Lung Qi deficiency: cough.
• Kidney Yang deficiency (fails to grasp the Lung Qi): asthma.
• Also for a combination of the two above syndromes, and consumptive cough, blood streaked sputum.
• Kidney Yang deficiency: impotence, daybreak diarrhea, frequent urination.
• Often made into a tonic wine – commonly using one male and one female gecko.
• The tail is considered the most effective part.
• The head and feet are usually not used in decoctions.
Joe Coletto: May counteract the destructive effect of steroids on the adrenals.
Dose: 3-7g directly as powder or 9-15g in decoction

Gou Ji – Cibotium barometz rhizome – “Dog Spine”

Nature: bitter, sweet, warm

Enters: Kidney, Liver

Actions: Tonifies the liver and kidneys; strengthens bones and sinews, the lumbar region and knees; eliminates wind-damp; consolidates Jing, stabilizes the kidneys.

Indications:
• Liver and kidney deficiency: stiffness, soreness, weakness of the knees, feet, lower back, spine, and lower extremities. Inability to lie flat without pain.
• Wind-cold-damp obstruction: pain, soreness, stiffness, numbness – in people with a weak constitution; also swelling of the legs.
• Primarily used for pain due to weakness (with or without concomitant wind-damp invasion). Mild for sexual dysfunction.
• Kidney deficiency (kidney yang unable to control Jing): urinary incontinence, profuse clear vaginal discharge, spermatorrhea, hypermenorrhea.
• Similar to Du zhong, but milder to tonify the kidneys and liver.
• Compared to Ba ji tian, this herb is drier.
• According to Chen & Chen in Chinese Medical Herbology & Pharmacology this herb is a mild Kidney yang tonic and must be combined with other yang tonics.
• Chen & Chen: Dry-frying it helps in removal of hair-like protrusions. This hair-like material can be used externally to stop bleeding.
Dose: 4.5-15g

Gu Sui Bu – Drynaria rhizome – “Mender of Shattered Bones”

Nature: bitter, warm

Enters: Kidney, Liver

Actions: Promotes bone and sinew regeneration; promotes blood circulation; tonifies the kidneys; stop bleeding; stimulates hair growth.

Indications:
• Kidney deficiency: lumbar pain, weak feet, lumbar region, knees, tinnitus, poor hearing, toothache, bleeding gums, chronic diarrhea.
• Traumatic injury: falls, fractures, contusions, sprains. Especially good for ligamentous injuries and simple fractures (use internally and externally). Also used to help regain strength during the convalescent phase following injuries.
• Topical (tincture): for hair loss/alopecia, corns, warts (soak 100g herb in 1 L white rice wine for at least a week).
• Stronger than Xu duan at promoting blood circulation, but weaker at tonifying the liver and kidneys.
• Treats adverse effects of streptomycin in patients with a sensitivity to it: headache, dizziness, numbness of the tongue, tinnitus, hearing loss.

Dose: 6-18g

Hu Lu Ba – Fenugreek seed – Trigonella

Nature: bitter, warm

Enters: Kidney, Liver

Actions: Warms the kidneys; disperses damp and cold, alleviates pain; increases lactation.

Indications:
• Kidney Yang deficiency with cold accumulation or stagnation Qi: abdominal or flank distention and pain or hernial disorders.
• Cold-damp leg qi: soreness, numbness, weakness, edema.
• Prevents and treats mountain sickness (in studies, was effective in about 1/3 of the subjects).
• May be useful in some forms of insomnia.
• Lowers blood sugar.
K&R: Hypoglycemiant, adrenal cortex stimulant, digestive tonic, lymphatic detergent, improves digestive absorption, eliminates intestinal mucus.
• Earth deficiency, metal deficiency.
Earth: digestive aid, hypoglycemiant, good for emaciation.
Metal: neuromuscular stimulant, good for emaciation (including diabetic), malnutrition, anemia, frigidity, impotence.
Water: impotence, frigidity, lumbar pain, dysmenorrhea.
• Opera singers used for centuries to clear excess phlegm from the throat.
• Claimed equal to quinine in preventing fever.
• Topical: for cellulitis.
• Chronic prostatitis, impotence.
BII: May lower blood lipids (LDL, VLDL and trigylcerides): atherosclerosis.
• Diabetes: may improve glucose tolerance.
Yoga: Methi: bitter, pungent, sweet/heating/pungent; V, K-; P+
• Stimulant, tonic, expectorant, rejuvenative, aphrodisiac, diuretic.
• Hypo-function of the liver, seminal debility, dysentery, dyspepsia, chronic cough, allergies, bronchitis, flu, convalescence, dropsy, toothache, neurasthenia, sciatica, arthritis.
• Take gruel to improve lactation milk flow and hair growth.
• Use paste for boils, ulcers, non-healing sores.
• Caution in pregnancy.
PCBDP: Trigonelline significantly inhibits liver carcinoma in mice, is used in China for cervical cancer.

Dose: 3-9g

Hu Tao Ren – Hu Tao Rou – Walnut (nut) – “Barbarian Peach Pit”

Nature: sweet, warm

Enters: Kidney, Large Intestine, Lung

Actions: Tonifies kidney Qi, strengthens the back and knees; warms the Lungs, tonifies Lung Qi; helps the kidneys grasp the Lung Qi; moistens the large intestine, unblocks the bowels.

Indications:
• Kidney Yang deficiency: weak, cold, painful lumbar region, feet, knees, frequent urination.
• Lung cold and Qi deficiency: cough, asthma.
• Lung and kidney deficiency: wheezing.
• Large intestine dryness: constipation, especially in the elderly or that from injured fluids following a febrile disease.
• Also used to dissolve/expel urinary stones.
• Use as a paste for contact, seborrheic, and atopic dermatitis.
• Its function to tonify Yang is very mild.
• The skin of the nutmeat is astringent. Eat this in order to help the kidneys grasp the Lung Qi. To promote bowel movement, remove this skin.
Jin: Eat in pregnancy for constipation. Also helps the baby’s brain develop.
DY: Invigorates Yang; calms or levels asthma; warms and supplements the life gate.
• With Bu gu zhi to supplement metal and water, to effectively constrain the Lung Qi and promote the intake of Qi by the kidneys, stop cough, and calm asthma. For the following indications, salt-processed Bu gu zhi should be used:
– 1. Cough, dyspnea, and asthma due to kidney Yang deficiency.
– 2. Lumbago, impotence, seminal emission, constipation, frequent and abundant urination, and enuresis due to kidney Qi deficiency.

Dose: 9-30g (eaten)

Jiu Zi – Jiu Cai Zi – Allium seed – Chinese Leek seed

Nature: acrid, sweet, warm

Enters: Kidney, Liver

Actions: Tonifies kidney Yang; controls Jing; warms the stomach, stops vomiting.

Indications:
• Kidney Yang deficiency: impotence, weakness, cold and pain in lumbar and knee, urinary incontinence.
• Kidney Qi deficiency: seminal emission, frequent urination, copious leukorrhea.
• Stomach cold: vomiting.
• Must crush before use.

Dose: 3-9g (decoctions, pills, and powders)

Lu Rong – Velvet Deer Antler

Nature: sweet, salty, slightly warm

Enters: Kidney, Liver

Actions: Tonifies kidney Yang; slightly nourishes kidney Yin; nourishes Jing and blood, supports the brain; strengthens tendons and bones; tonifies the Du Mai (governing vessel); regulates the Chong Mai (penetrating vessel) and Ren Mai (conception vessel), and stabilizes the Dai Mai (girdle vessel).

Indications:
• Kidney Yang deficiency: intolerance to cold, cold extremities, impotence, seminal emission, infertility, frequent, clear urination, dizziness, sore and weak lumbar region and knees, fatigue, lightheadedness, tinnitus.
• Jing and blood deficiency: mental and physical retardation or deformity, weak tendons and bones, failure to thrive, learning disabilities, insufficient growth, Down’s syndrome, rickets – especially in children.
• Kidney Yang deficiency with cold in the Chong, Ren, and Dai Mai: copious leukorrhea, uterine bleeding, infertility with a cold womb.
• Qi and blood deficiency: chronic ulcerations or Yin-type boils (those that are concave, ooze a clear fluid, and do not heal).
• Diuretic.
• Doctrine of signatures: the antler is an extension of the deer’s Du Mai.
• It is important to start with a low dose and slowly increase it. If too much is taken at the beginning, the Yang can rise, leading to internal wind with dizziness and red eyes, or it can injure the Yin, leading to deficiency fire and even hemorrhage. In my experience, the most common side effect is an “edgy” feeling – irritable, or slightly physically overwhelmed, similar to having too much caffeine.
• Antler products are generally too valuable to cook. Take as powder or in wine.
• All antler products are contraindicated in cases of Yin deficiency heat.
• Contains pantocrinum: can regulate arrhythmias, improve poor circulation, increase work capacity, improve sleep and appetite, decrease rate of muscle fatigue.
Matthew Wood (Lecture notes): Lyme disease is caused by the same spirochete which lives on deer and stimulates their antlers to grow.
Hong-Yen Hsu (Oriental Materia Medica): Raises RBC count and hemoglobin, promotes growth and development, cardiotonic, increases uterine tonicity.
Weng Weiliang, et al: This TCM herb is indicated in the treatment of backache, impotence, emission, enuresis, sterility, aplastic anemia, senile osteoporosis, senile diarrhea, Raynaud’s disease, senile intractable cough and asthma, thromboangitis obliterans, lobular hyperplasia of mammary glands, etc.
• Lobular hyperplasia of mammary glands: Lu Jia San (experiential formula): lu jiao pian, chuan shan jia, 60g each; wang bu liu xing, sang leng, e zhu, 100g each; all the drugs were ground into fine powder. 9g, tid. 40 cases of lobular hyperplasia of mammary glands were treated with this method, after three months, 36 were effective.
• Hypothyroidism: Shen Lu tablet (experiential formula): lu jiao pian 4.5g, yin yang huo 30g, dang shen 12g, suo yang 12g, gou qi 9g. Each tablet contained 6g crude drugs, 5 tablets every time, three times daily, 3 months as a course of treatment. All the treated 32 cases were effective.
• Senile intractable cough and asthma: ma huang, 20g; bei xi xin, 10g, bai jie zi, gan di long, 15g each; lu jiao pian, wu wei zi, kuan dong hua, gan jiang, 10g each; dang shen, 24g, yin yang huo, 12g; shu di, 30g; rou gui, 5g. Modify the formula according to TCM differentiation, water decoction. 50 cases were treated and 48 were effective.
• Female low sexual function: Yi Shen Zhu Yang Tang (experimental formula): lu jiao shuang, 30g; shu di, shan yao, shan yu rou, gou qi, nu zhen zi, tu si zi, she chuang zi, yin yang huo, 15g; huang jing, gui ban jiao, 12g each; rou gui, 8g. With qi stagnation, add he huan pi 12g, xiang fu and chai hu 8g each; with Blood stasis, add dang gui, chuan xiong, and yi mu cao, 10g each. 1 dose every day, water decoction, 1 month as a course of treatment. 35 cases were treated, 33 were effective.
Subhuti Dharmananda: Deer antler is a common ingredient in Chinese tonic preparations. It may be surprising, especially to the practitioner of Chinese medicine, to learn that New Zealand is the world’s largest producer of deer antler, followed closely by Australia and Canada (both increasing rapidly), and that Korea is probably the world’s largest user of antlers, with an apparently insatiable appetite for antlers of all species. China is also a major producer and consumer of deer antler products and appears to have the longest history of medicinal use of deer antler as well as production via deer farming.
The story of deer antler can be traced back to the first Chinese Materia Medica, Shennong Bencao Jing (ca. 100 A.D.), where it is described briefly (1). There is also reference to earlier use of deer antler in an archeological find (a set of silk scrolls named Wushier Bingfang, from a tomb dated 168 B.C.). However, use of antler appears to have been infrequent until the animals were raised on “deer farms” starting in the mid-16th Century in China (Ming Dynasty period). This is a time when several other cultivation and animal husbandry projects were established in support of medicine. Soon after, Wu Kun included a formula in his book Yi Fang Kao (Study of Prescriptions, 1584) that has inspired much work with the combination of deer antler and tortoise shell, two bone-like materials rich in gelatins. His formula is Gui Lu Erxian Jiao (gui = tortoise, lu = deer, erxian = two immortals; jiao = gelatin). The formula is made as a firm gelatin, using the following recipe (proportioned to the amount being made):
Deer antler (lujiao) 5,000 g
Tortoise plastron (guiban) 2,000 g
Lycium fruit (goujizi) 1,500 g
Ginseng (renshen) 500 g
This formula is said to replenish yin and essence, tonify qi, and strengthen yang. It is used for deficiency of kidney yin and yang, deficiency of blood and essence in the penetrating and conception vessels, with symptoms of weakness of the lower back and legs, impotence, blurred vision, etc. (2). The penetrating vessel, (chongmai), one of the extra meridians, is referred to as the “sea of blood.” The conception vessel (renmai), while sometimes associated with reproduction, is related to generation more broadly, including generation of blood. Tortoise shell and deer antler are said to nourish the marrow.
More importantly for the future of Chinese herb prescribing with deer antler, Zhang Jingyue described two important tonic formulas in pill form (presented in the book Jingyue Quanshu, 1624), one to emphasize tonification of kidney yang (said to nourish the right kidney), called Yougui Wan, and one to emphasize nourishing kidney yin (said to nourish the left kidney), called Zuogui Wan. Though prepared originally as pills (= wan), they were later commonly used as decoctions for replenishing the kidney (you = right; zuo = left; gui = replenish).
Both formulas contain deer antler gelatin derived from boiling the antler (described further below). Chinese doctors regard the whole antler as primarily a revitalizing yang tonic with some yin nourishing qualities, while the gelatin is considered to be a milder yang tonic, with greater emphasis on nourishing yin, in a manner similar to tortoise shell (which lacks yang tonic properties). Both of Zhang Jingyue’s formulas nourish the kidney yin and essence, and both nourish yang, but Yougui Wan also warms the kidney and invigorates yang. To further emphasize yang tonification, deer antler may be used in place of the gelatin in Yougui Wan.
Because of the rather late introduction of antler in standard traditional Chinese medicine formulations, this ingredient rarely appears in Japanese preparations. The last major influence on Kampo from China was Gong Tingxian (1522-1619) with his book Wanbing Huichun (1587). He did not emphasize kidney tonification strategies. As a result, the Kampo literature doesn’t reveal antler-based formulas.
During the Qing Dynasty (1644-1910), the use of ginseng and deer antler became quite popular as a method of therapy, sometimes referred to as warm tonification. The Qing Dynasty medical commentator Xu Dachun (1693-1773) complained about over-reliance on these remedies (3):
Those physicians who prefer to be fashionable use only rapidly supplementing acrid and hot substances, namely ginseng, aconite, dry ginger, red atractylodes, deer antler, and cooked rehmannia. And no matter whether a patient was harmed by cold, heat, or dampness, these physicians go back and forth between these few herbs to compose their prescriptions. Often enough, these herbs are contraindicated in the case of the illness to be treated, and every trial is bound to kill someone. Still, there is not the slightest self-reproach.
Well, this has its origin in the physicians of today who prefer to make lofty speeches to deceive the people. Also, people are pleased if one uses warm and supplementing herbs, and this applies, in particular, to the rich and noble. Those physicians who do not follow these preferences of their patients will not be able to continue their profession for long! Hence, people strive to achieve the best effects, but they cause only unending calamity.
The acrid herbs were dry ginger, aconite, and red atractylodes (which was used at that time as we now use white atractylodes), and all the herbs mentioned were warming, some of them considered hot (though today, all are classified as warm except dry ginger and raw aconite, but not processed aconite). These invigorating tonics were expected to cause people to feel an immediate response to the therapy-a stimulation of their basic energy-compared to the usual tonification approach which might require weeks of regular use of the herbs and a nearly imperceptible daily improvement. Some of these herbs, like ginseng and deer antler, were rare and costly, so the rich sought them out, figuring that they had unique access to important remedies. It is much the same today: many people seek quick fixes and may be drawn to the unusual costly herbs if they can afford them.
Xu argued that reliance on a few popular and quick acting agents tends to be contrary to the most widely accepted methodology, which is to perform differential diagnosis and then prescribe according to need, regardless of the ordinary nature of some herbs or their lack of contemporary popularity. Hence, these warm tonifying agents might be contraindicated in cases of heat syndrome, damp-heat, blood heat, stomach fire, phlegm-heat in the lungs, and yin deficiency leading to excess yang. There was much concern during his time about killing patients with wrong prescriptions. Working in the absence of modern medicine, the remedies were used for people with fatal diseases who would die if not cured, and who might be worsened by some of the therapies (for example, raw aconite could be quite toxic if not cooked properly in making a tea). These specific concerns aside, all of the herbs mentioned were recognized as valuable, so long as they were given according to need.
The use of deer antler continued through the Qing Dynasty at a modest level until the 20th century, when it became the subject of modern research methods. Both the Russians (who had been farming deer antler since the 1840s) and the Chinese started subjecting deer antler to analysis by scientific methods, though those methods were relatively crude. About the same time, patent medicine factories sprung up in China and helped fill the growing demand for tonics made with rare ingredients such as deer antler and ginseng. Chinese patent medicine factories now use more than 1,000 kg of deer antler each year. This increased interest and distribution, in turn, led to rapid build-up in the number and size of deer farms.
SPECIES OF DEER
Initially, antler was collected from several species of wild deer (animals of the Cervidae family). There are 45 species of deer in the world, divided into 17 genera; not all of them have antlers. Two species of deer have been the common source of domestic deer antler for Chinese medicine: Cervus nippon, the sika deer, and Cervus elaphus, the red deer.
The sika deer is an East Asian species, ranging from Vietnam to Taiwan in the south and from China to Korea and Japan in the north; there are about 13 different subspecies of this deer. The sika deer mainly lives in open woodlands and is typically a chestnut red to yellowish brown with white spots on the sides and a dark stripe extending from neck to tail. Sika deer have been introduced to New Zealand for deer farming to produce antlers, and have also been introduced into Europe.
The red deer originally ranged from Europe to Asia, and it has been introduced into New Zealand, Australia, Chile, and Argentina for the purpose of deer farming to produce antler. It has a glossy reddish brown color in summer (but in winter turns drab grey-brown). Red deer prefer open, grassy glades in the forest, but frequently use woody cover.
DEER FARMING
Deer farming has become a huge enterprise outside the Orient. The animal meat is used as food, and the antlers are usually exported to the Orient, though there is a new industry in making antler-based health products for domestic consumption in Canada and other countries. The table on the next page indicates the extent of deer farming (adapted from ref. 4).
In Korea, the biggest consumer nation for deer antler, data from the end of 1992 indicated that 143,000 deer were held in pens (about 20 deer each), producing about 100 tons of fresh antler, which yields about 30 tons of dried product (6). That same year, about three times as much was imported, mainly from New Zealand, Russia, and China. China later became an antler importer rather than exporter, except for finished medicinal preparations and small supplies sent to oversea Chinese pharmacies.
The primary material collected at the deer farms is called velvet. The term originally arose from the fine hairs on the antler, but is now used specifically to indicate the antler’s stage of growth: before it calcifies (ossifies). In nature, antlers will fall off after they have ossified; thus, collecting fallen antler doesn’t provide the desired “velvet.” The older material is still valued: it is boiled to yield deer antler gelatin (described below) and used for certain applications, such as dispersing swellings.
Deer velvet is removed while the deer is under local anesthetic (which is a new practice in China and is a mandated practice in other countries that developed deer antler farming more recently). The antlers then grow back. Alternatively, if the deer is killed for use as food, the antlers are removed afterward. The cut antlers are bathed in boiling water and air dried, and then further dried in the shade or by low temperature baking. The fine hairs may be removed before additional processing. A typical dried antler from the sika deer weighs about 150 grams.
ANTLER PREPARATIONS
Traditionally, deer antler is sliced very thinly or ground to powder. It is not commonly boiled in decoctions with herbs because the gelatins easily stick to the herb dregs or cooking pot, and so the loss of valuable material is considered too great. Therefore, the herb powder is usually taken separately.
To make gelatin, ossified antlers (which are less expensive than velvet) are boiled for several hours to release the gelatin (protein components) from the hard matrix. Then, the antler gelatin can be added to an herbal decoction after all the boiling is done and the dregs have been strained. Or, it too can be ground to powder, and consumed directly. After removing the gelatin from the antler, the residual hard antler material is dried and ground up to make lujiaoshuang (degelatinized deer antler), which is mostly used for topical applications (treating boils, eczema, and skin ulcers, serving as an astringent and aid to faster healing). It is also considered of some limited value as a kidney yang tonic if taken at high enough dosage.
Antler pills are a common patent medicine product; the antler is not used alone, but in various formulations. These include liquids in glass vials (ginseng-deer antler, similar to the ginseng-royal jelly product; there is a combination with ginseng, antler, and royal jelly); pills used as sexual tonics (antler combined with epimedium, cynomorium, ginseng, and lycium fruit); and general tonics (complex formulas with herbs for tonifying qi and yang, and nourishing yin and blood).
The thin slices are made by removing the outer, hairy portion of the antler, soaking the antler in hot alcohol to soften it, and then carefully slicing it to produce round wafers. The slices are best suited for soaking in wine to make a “tincture” of antler, sometimes referred to as pantocrin (or pantocrine), based on the Russian designation for the alcohol extract. Very thin slices (virtually clear) can be eaten directly.
ANTLER CONSTITUENTS
Antler is a simple extension of bone, so it has a calcium-phosphate matrix of hydroxyapatite, Ca10(PO4)6(OH)2, integrated with smaller amounts of calcium carbonate (CaCO3); its composition is similar to that of human bones. Thus, one of the therapeutic roles of taking deer antler is as a source of calcium to help prevent or treat osteoporosis, which is consistent with the traditional bone strengthening action of deer antler. An analysis of the ossified antler showed that 73% is hydroxyapatite and related mineral compounds, while 27% is organic materials (7). If consumed as a powder (rather than a decoction), a person taking 3 grams of deer antler (see dosage section, below) will get about 800 mg of calcium. Hydroxyapatite is considered one of the most efficiently absorbed forms of calcium available. In velvet, the hydroxyapatite is about 50% (8), so the calcium in 3 grams is about 600 mg.
Deer antler also has a substantial amount of gelatinous components, ones that have become widely publicized in recent years, though from other source materials: glucosamine sulfate, chondroitin sulfate (which is a polymer of glucosamine), and collagen. These compounds have been shown to benefit the joints in cases of osteoarthritis by providing substrate materials useful for regenerating the body’s connective tissues (collagens) found in joints and sinews. In addition, they may have some anti-inflammatory action, useful for arthritis and tendonitis. These actions of the gelatin portion support the traditional concept that antler benefits joints and ligaments. In a 3-gram dose of ossified deer antler powder, one will obtain about 750 mg of these substances, which is low compared to therapeutic amounts taken as supplements for osteoarthritis (about 1,500 mg/day); 3 grams of velvet antler will provide the desired 1,500 mg. If deer antler gelatin is consumed, there is an even higher proportion of these ingredients, though some of the components may be transformed during the prolonged boiling into less active forms, so the dosage of gelatin to use is higher than for antler velvet.
Recently, the traditional use of antler to nourish the bone marrow and blood has been validated by studies in which the active components responsible were identified: monoacetyldiglycerides (9, 10). These are small molecules that stimulate the marrow stem cells that produce blood cells (see illustration, next page; 11). Inhibition of hematopoiesis (blood cell production) occurs with several cancer drugs and with radiation therapy; some disease processes, such as myelodysplastic syndrome (MDS), involve progressive decline in stem cell activity with undetermined causes. If further research confirms the therapeutic importance of the monoacetyldiglycerides, they can be synthesized in large quantity. In the meantime, deer antler is the main therapeutic source for them (the amount present in antler has not been quantified).
Deer antler also has essential fatty acids, making up about 2.5% of the velvet antler (not enough to be clinically active) and insulin-dependent growth factor (for which it is not known whether there is any clinical effect). Other organic compounds have been detected, but in miniscule amounts.
DOSAGE
The velvet antler in powdered form is typically used in dosages of 1-3 grams/day. Less than 3 grams may be a low dosage for promoting bone marrow function; the dosage levels traditionally indicated may reflect the rarity and expense of the antler (which is now partly alleviated by the increase in deer farming, but velvet is still relatively costly). The 3-gram dosage is probably essential for hematopoietic effect and for benefiting joints and tendons. Antler gelatin, because it is obtained from older antler material, is relatively inexpensive, is milder, and is used in larger quantities, 6-9 grams. Degelatinized antler is consumed in dosages of 6-9 grams, or more.
TRADITIONAL MEDICINE COMMENTARIES
The book Ten Lectures on the Use of Medicinals from the Personal Experience of Jiao Shude (12) provides these insights:
Lurong (velvet deer antler): Warm in nature and sweet and salty in flavor, lurong supplements kidney yang, strengthens sinew and bone, boosts sinew and marrow, and nourishes the blood. It is used for patterns of vacuity detriment, such a kidney deficiency and cold limbs, soreness of the limbs, dizzy head and blurred vision, seminal emission, and impotence.
Lujiao (ossified deer antler): Salty in flavor and warm in nature, lujiao supplements kidney yang and boosts essence and blood. It is similar in action to, and can substitute for, lurong, but it is less effective.
Lujiaojiao (deer antler gelatin): Sweet in flavor and warm in nature, lujiaojiao warms and supplements the kidney, supplements yang within yin, frees the blood of the thoroughfare vessel (chongmai), engenders essence and blood, and stanches flooding (excessive uterine bleeding)….It is mostly used for flooding and spotting, vaginal discharge, deficiency bleeding, and yin type flat-abscess (lumps that are not red, swollen, hot, or painful).
Comparisons: Lurong is commonly used as a drastic liver-kidney supplementing medicinal. It has greater supplementing power than lujiao. Lujiao, by contrast, has a moderate liver-kidney supplementing effect, but it quickens the blood, dissipates stasis, and disperses swelling and toxin with greater strength than lurong…. Used processed or as a glue (lujiaojiao), it tends to warm and supplement the liver and kidney, enrich and nourish essence-blood. Lujiaojiao is similar in action to lurong, but being slower to supplement, it must be taken over a long period of time to be effective. Lujiaoshuang, which is the dregs left after making lujiaojiao, is less warming and supplementing than either lujiao or lujiaojiao. Lujiaoshuang is used for spleen-stomach deficiency cold, low food intake, and sloppy stool, and it is also used as a substitute for lujiao and lujiaojiao, in which case the dosage must be increased.
The problem of “flooding” and spotting was described by Liu Yiren in his book Heart Transmission of Medicine (ca. 1850; 13):
The disease of flooding and leaking is due to detriment of the chong (penetrating) and ren (conception) vessels. The chongmai is the sea of blood of the twelve channels, and the renmai is the original qi of engenderment and nourishment. If these two vessels suffer detriment, the blood will consequently move frenetically. At its onset, this disease is categorized as repletion heat, requiring clearing heat. Later on, it is characterized as deficiency heat, requiring nourishing the blood and clearing heat. If it endures for many days, it is categorized as deficiency cold, requiring warming the channels and supplementing the blood.
Although antler wasn’t commonly used during Liu Yiren’s time, it would today be a primary choice for treating the deficiency cold syndrome that he described. Since bleeding is part of the syndrome, antler gelatin would be utilized, probably with tortoise shell.
The Advanced Textbook of Traditional Chinese Medicine and Pharmacology (14) notes the main uses for deer antler (lurong):
a) Chronic diseases marked by general lassitude and spiritlessness, lumbago, and cold limbs, polyuria with clear urine, impotence, spermatorrhea, and leukorrhagia with clear discharge, for which it is often used with cooked rehmannia, eucommia, and cistanche.
b) Infantile maldevelopment marked by weakness of the muscles and bones, incomplete closure of the fontanel, and retarded speech and movement, for which it is often combined with cooked rehmannia and cornus [it is sometimes added to Rehmannia Six Formula, which has these ingredients, and which was designed for promoting healthy growth of children who displayed slow development].
c) Chronic diseases with blood deficiency and liver and kidney deficiency, for which it is often used with ginseng, astragalus, cooked rehmannia, and tang-kuei.
d) Deficiency of the extra meridians (e.g., chongmai) with incessant uterine bleeding, for which it is often prescribed with gelatin, sepia bone, tang-kuei, and tortoise shell.
The effects of lujiao, lujiaojiao, and lujiaoshuang derived from the antlers are basically the same: warming and nourishing kidney yang. But, lujiao also activates blood circulation and relieves swelling, lujiaojiao is more effective for nourishing blood and checking bleeding, and lujiaoshuang possesses an astringent effect [e.g., for incontinence of urine, uterine bleeding, and leukorrhea].

Dose: 1-3g (take directly, divided into two or three doses over the course of the day)

Lu Jiao – 2-3 Year Old Deer Antler

Nature: salty, warm

Enters: Liver, Kidney

• Weaker than Lu rong to tonify, but also promotes blood circulation, reduces swelling.
• Good for kidney Yang deficiency with blood stagnation.
• Non-healing fractures.
• Toxic sores and swellings.
• Breast abscesses.
• Pain from blood stasis and deep pain in the lower back.

Dose: 5-10g

Lu Jiao Jiao – Gelatin Made from Mature Deer Antler (Lu Jiao)

Nature: sweet, salty, slightly warm

Enters: Kidney, Liver

Actions: Tonifies liver blood and kidney Jing; stops bleeding.

Indications:
• Kidney Yang deficiency: intolerance to cold, cold extremities, impotence, seminal emission, infertility, frequent urination, dizziness, weak lumbar region and knees, fatigue.
• Kidney Yang deficiency cold: hematemesis, epistaxis, hematuria, uterine bleeding.
• Non-healing Yin-type carbuncles.
• Do not cook – melt into a warm decoction or yellow wine.
• Can be combined with Chen pi to counteract its greasiness.
Dr. Wei Li: Strong blood tonic, great for chemotherapy patients.

Dose: 6-12g

Rou Cong Rong – Cistanche stem – Broomrape

Nature: sweet, salty, warm

Enters: Kidney, Large Intestine

Actions: Tonifies kidney Yang; moistens the large intestine, promotes bowel movement; warms the womb.

Indications:
• Kidney Yang deficiency: impotence, infertility, weakness and cold pains in the lumbar region and knees, urinary incontinence, posturinary dripping, spermatorrhea.
• Large intestine dryness: constipation .
• Deficiency cold womb: infertility, excessive uterine bleeding, vaginal discharge.
• Stronger than Ba ji tian to tonify Jing and blood and to moisten the large intestine.
• Sticky, but not greasy – a large dose will not hurt the spleen.
• Tonifies the Yang yet is not drying; its effects are moderate.
• Treated with salt for frequent urination or spermatorrhea.
• Increases secretion of saliva.
• Currently in protected status. Becoming increasingly difficult to find in U.S.
Jin: Tonifies both the kidneys and spleen. Not drying like some other Yang tonics.
Hsu: Laxative, hypotensive.

Dose: 9-21g

Sha Yuan Ji Li – Sha Yuan Zi – Sha Ji Li – Astragalus seed

Nature: sweet, warm

Enters: Liver, Kidney

Actions: Tonifies kidney Yang; controls Jing; nourishes liver Yin to improve vision.

• Kidney Yang deficiency: lumbar pain, impotence, seminal emission, frequent urination, urinary incontinence, copious leukorrhea, premature ejaculation.
• Liver Yin (and kidney) deficiency: poor or blurry vision.
• Compared to Tu si zi, Sha yuan ji li focuses more on improving the vision, whereas Tu si zi focuses more on tonification.
Hsu: Antidiuretic, stimulates uterine contraction.
DY: Astringing (secures the essence); harmoniously supplements Yin and Yang.
• With Bai ji li to regulate upbearing and downbearing and the liver and kidneys. Together, they course the liver and rectify Qi, resolve depression and calm the liver. They harmoniously supplement the liver and kidneys – they enrich the kidneys and secure the essence, nourish the liver and brighten the eyes. For such indications as:
– 1. Vertigo, unclear vision due to liver and kidney deficiency. (Use salt mix-fried Bai ji li.)
– 2. Lumbar pain, seminal emission, premature ejaculation, frequent urination due to kidney deficiency. (Use salt mix-fried or stir-fried Sha yuan zi.)
– 3. Abnormal vaginal discharge due to kidney deficiency.

Dose: 6-15g

Suo Yang – Cynomorium stem – “Lock Yang”

Nature: sweet, warm

Enters: Liver, Kidney, Large Intestine

Actions: Tonifies kidney Yang; moistens the large intestine, promotes bowel movement; nourishes blood and Jing; strengthens the sinews.

Indications:
• Kidney Yang and Jing deficiency: infertility, impotence, spermatorrhea, weakness of the lumbar region and knees, weakness of the tendons and bones, frequent urination.
• Large intestine dryness (Qi and blood deficiency): constipation.
• Jing and blood deficiency: weakness of the sinews, motor impairment, paralysis, muscular atrophy.
• Doctrine of signatures: for impotence – see morphology of the stem.
• Stronger than Rou cong rong at tonifying kidney Yang, but weaker at moistening the large intestine and promoting bowel movement.
Subhuti Dharmananda: Cynomorium is known in Chinese as suoyang, which is based on the herb’s medicinal effects, “locking the yang.” It is obtained mainly from the East Asian species, Cynomorium songaricum, though the similar C. coccineum is sometimes utilized as a substitute (and is used in other countries, from Europe to Central Asia, where it is the native species). The plant harvested for Chinese medicine grows at high altitude, mainly in Inner Mongolia, Qinghai, Gansu, and Tibet. It is used to tonify the yang (treat impotence and backache), strengthen the tendons, and nourish the blood to alleviate the blood-deficiency type of constipation (typically occurring with old age).
The value of cynomorium was depicted similarly in many cultures. In 16th century Europe, it was known as the Maltese mushroom, though it is not a true fungus. The plant was so highly regarded that the Knights of Malta often sent samples of it to European monarchs as presents. To protect the so-called Fungus Rock, where cynomorium was abundant, the grandmaster posted guards around the area and ordered the sides of the outcropping to be rendered smooth to eliminate any footholds and prevent access from the sea. The rock, rising to a sheer height of 60 meters (200 feet) from the rough sea, became virtually inaccessible. As an explanation of its uses by the doctrine of signatures, since the plant appears reddish-brown, and becomes darker upon drying, herbalists thought it would be useful to treat ailments of the blood. On top of that, the phallic shape indicated the plant could also be used to treat sexual problems. The dried spikes were used by the Crusader Knights after their battles to recover strength. In Saudi Arabia, the plant is called tarthuth, and is recognized to have the same properties mentioned above, as well as many others, including treatment of digestive disorders and ulcers (see Appendix for story).
Cynomorium is parasitic on the roots of salt-tolerant plants, mainly species of Atriplex, the “saltbushes” (for C. coccineum) and on Nitraria sibirica (for C. songaricum). The plant has no chlorophyll; the fleshy red stems or spikes have tiny scarlet flowers. Its active constituents have not been fully analyzed, but cynomorium is known to contain anthocyanic glycosides, triterpene saponins, and lignans. Pharmacology experiments are in the early stage, with attempts to demonstrate a hormonal effect that would explain its use in impotence (its current main application in commercial products), as well as findings that the herb extracts inhibits HIV, lower blood pressure, and improve blood flow in laboratory experiments.
Cynomorium, which has a pleasant, sweet taste when raw, has long been known as a “famine food,” that is, something not frequently eaten, but nourishing enough to help people survive when the standard foods are insufficient. In fact, a city in China is named for cynomorium because of this benefit. The city is near Anxi (in today’s Gansu Province), which lies at the center of the ancient Silk Road, and was long considered as the key to the West. During the Tang Dynasty, Anxi was established as a military base to gain control over Middle Asia. About 40 miles away was an old Han Dynasty town called Kugucheng, also of strategic military importance. Numerous walls and gates were set up to form a line of defense. During the Tang dynasty, the famous general Xue Rengui and his army were besieged in the Anxi area while on the way to conquer the West. The soldiers had used up all their supplies and they had no hope of assistance. Yet, they were able to survive by eating suoyang, and after that the city was renamed as Suoyang.
Cynomorium didn’t enter into the Materia Medica until Zhu Danxi of the Yuan Dynasty period mentioned it in his Bencao Yanyi Buyi (Supplement and Expansion of Materia Medica, 1347). The Yuan Dynasty, which was the time of Mongolian rule, introduced several plants from the Mongolian area, including this one. Zhu Danxi also offered a formula with cynomorium that became quite famous, Huqian Wan (Hidden Tiger Pills), used for impotence and/or for weakness and atrophy of the legs. The formula is named for the tiger in crouched position, ready to spring. In order to attain that position (which is also replicated in Gong Fu with the “crouching tiger” technique), one must have great strength in the tendons, ligaments, and muscles of the legs. This strengthening is sometimes referred to as “hardening” of yin (substance of the body); but that doesn’t necessarily indicate lack of flexibility. The weak leg disorders were first described in the Neijing Suwen (ca. 100 A.D.), in the chapter on wei syndrome, which is translated as atrophy or wilting syndrome. There were five types of atrophy listed, associated with each of the five organs. The disorder was thought to derive from heat or damp-heat damaging the yin.
Huqian Wan is comprised of anemarrhena, phellodendron, cooked rehmannia, tortoise shell, tiger’s bone (no longer used), peony, citrus, and dry ginger; sometimes cistanche (another parasitic desert plant) is added. The formula was recently described by Kong Lingqi (Resolutely Upholding the Concept of Hardening the Kidneys Method, by Kong Lingqi, Sichuan Chinese Medicine, 1998 (6): 8-9, translated by Bob Flaws, and edited here):
The Suwen chapter titled Treatise on Wilting says, ‘The ancestral sinews rule the binding of the bones and the disinhibition of the joints.’ If damp heat invades and assails the muscles and flesh and sinews and bones, the qi and blood will not move. The sinews will become slack and not pulled together and, hence, will be useless. If severe, the liver and kidneys will become debilitated and consumed and the ancestral sinews will cease their duty. Master Ye Tianshi, in his Guide to Clinical Conditions & Case Histories chapter titled Vacuity Taxation highly praised Zhu Danxi’s Huqian Wan for their effect of subduing yang and hardening yin. These pills use phellodendron and anemarrhena’s bitterness to harden yin. This causes the source to be cleared and flow to be cleaned. Atractylodes (cangzhu) and coix (yiyiren) dispel dampness. Cistanche (roucongrong), cynomorium (suoyang), achyranthes (niuxi), and tiger bone (hugu) strengthen the sinews and bones. Peony (baishao) and chaenomeles (mugua) emolliate the sinews and relax tension. Cooked rehmannia (shudi) and tortoise shell (guiban) enrich yin and boost the marrow. Thus damp heat is discharged and transformed, yin essence is subdued and astringed, the ancestral sinews are hardened and strengthened, and the feet are able to walk.
Because of these uses, the formula has been suggested by Chinese clinicians as a possible therapy for paralytic disorders, such as multiple sclerosis and ALS.

Dose: 4.5-15g

Tu Si Zi – Cuscuta seed – Chinese Dodder

Nature: sweet, acrid, neutral

Enters: Liver, Kidney

Actions: Tonifies kidney Yang; mildly nourishes kidney Yin; controls Jing and urine; improves vision; tonifies spleen Qi to stop diarrhea; calms the fetus.

Indications:
• Kidney Yang deficiency: impotence, frequent urination, tinnitus, copious leukorrhea, weak and sore lumbar region and knees, nocturnal emission without dreams.
• Liver and kidney Yin deficiency: blurry vision, seeing spots, dizziness, tinnitus.
• Habitual or threatened miscarriage.
• Spleen Qi deficiency (with concurrent kidney deficiency): diarrhea or loose stools, poor appetite.
• Do not count on this herb for tonification of spleen Qi – use it when there is also kidney Yang/Qi deficiency.
• Compared to Sha yuan ji li, Tu si zi focuses more on tonification, whereas Sha yuan ji li focuses more on improving the vision.
• Because this herb is a parasite of some agricultural crops, it must usually be sterilized before entry into the United States.
MLT: A tonic specific for low sperm count and inactivity of sperm.
Hsu: Cardiotonic, hypotensive, stimulates the uterus, decreases the size of the spleen, inhibits intestinal activity.

Dose: 9-15g

Xian Mao – Curculigo rhizome – Golden eye-grass – “Immortal Grass”

Nature: acrid, slightly toxic, hot

Enters: Liver, Kidney

Actions: Tonifies kidney Yang – can reach and tonify the Ming Men; eliminates cold and damp.

Indications:
• Kidney Yang deficiency: impotence, nocturnal emission, urinary incontinence, cold in the chest and abdomen, infertility from cold Jing or cold womb.
• Cold-damp Bi: cold and pain in the lumbar region, knees, abdomen, a sense of weakness in the bones and sinews.
• Especially useful for cold abdominal or lower back pain.
• Often taken soaked in wine by itself.
• Compared to Ba ji tian and Yin yang huo, Xian mao is stronger and harsher. It should not be taken long term.
• Toxic reactions, such as swelling of the tongue, can occur. This can be alleviated with a decoction of Da huang, Huang lian, and Huang qin.
MLT: For menopausal symptoms from deficiency of both Yin and Yang.
• Use as an alternative to Fu zi and Rou gui when they would be too heating and stimulating.

Dose: 3-10g (10g for impotence)

Xu Duan – Dipsacus – Teasel root – “Restore What is Broken”

Nature: bitter, sweet, acrid, slightly warm

Enters: Liver, Kidney

Actions: Promotes tendon and bone regeneration, generates flesh; tonifies the liver and kidneys; promotes blood circulation, alleviates pain; stops uterine bleeding; calms the fetus.

Indications:
• Liver and kidney deficiency: weak lumbar region, knees and legs, stiff joints, seminal emission, uterine bleeding, threatened miscarriage with bleeding, restless fetus.
• Topical or internal: for trauma, sores, pain, swelling, Bi syndrome (especially of the lumbar region and limbs).
• Given its ability to control excessive menstrual bleeding, its Yang nature, and its ability to support a fetus, Kou believe this herb has a progesterone-supporting effect and in high doses (30-60g), he says it effectively treats estrogen dominance.
• Tonifies without causing stagnation.
• Much milder than Du zhong at tonifying the liver and kidneys.
• Compared to Du zhong, Xu duan is used more to treat lower back pain with significant aspects of both wind-damp and kidney deficiency, while Du zhong is more effective when the problem is due primarily to deficiency.
• Fry in vinegar to enhance its ability to promote blood circulation and alleviate pain.
• Roasting with salt facilitates its entry into the kidney channel.
• Dry-fry or char for excessive uterine bleeding.
• Powder for topical application.
Hsu: Induces eruption of pus, stops bleeding, promotes tissue regeneration, analgesic effect on patients with carbuncle dermatosis.
Dui Yao (Sionneau & Flaws): Stops metrorrhagia during pregnancy.
• With Du zhong for mutual reinforcement, to supplement the liver and kidneys, strengthen the sinews and bones, stop metrorrhagia during pregnancy, and quiet the fetus. For specific indications and notes, See Du zhong in this category.
Matt Wood: For torn, stretched or wrenched joints, especially in large people who throw joints out with force. Chronic muscle inflammation, limitation of movement, great pain. Widespread arthritis, stiffness, incapacitation.
• Nerve irritation, sciatica.
• Intermittent fever.
• Regarding its literal translation, “restore what is broken,” it can be used for anything “broken” in one’s life, so that a part of one’s path cannot become manifest. “For people who had a use but lost it.” Helplessness, loss of purpose.
• Powerful remedy for Lyme disease (“deer syphilis”) and Lyme-like diseases. Deer appreciate this plant for relieving a disease they carry the vector for.
• MW dosing: 1-3 drops tincture 1-3 times daily. If this produces an aggravation, the dose may be lessened. Caution: may cause a healing crisis first (perhaps syphilis-like, genital rash, etc.).
• Doctrine of signatures: The thorny stalks are a signature for tension and nerve irritation. The tall, hard stalks which remain strong through the winter seem to indicate an affinity for the bones. At intervals along the stem the opposite leaves merge to form a cup which holds water after a rain – a remedy for joints and the kidney essence.

Dose: 6-30g

Yang Qi Shi – Actinolite – “Stone for Raising the Yang”

Nature: salty, slightly warm

Enters: Kidney

Actions: Tonifies kidney Yang; warms the womb.

Indications:
• Kidney Yang deficiency: impotence, infertility, spermatorrhea, premature ejaculation, cold, soreness, weakness and pain in the lumbar region and knees.
• Cold womb: infertility, uterine bleeding.
• Increases female libido.
• Not for long term use.
• Contains oxides of iron, calcium, and magnesium, plus about 50% silica.
• Usually calcined.

Dose: 3-9g

Yi Zhi Ren – Black Cardamom – Alpinia oxyphylla – Bitter-seeded Cardamom – “Benefit Intelligence Nut”

Nature: acrid, warm

Enters: Spleen, Kidney

Actions: Warms the spleen, stops diarrhea, promotes food intake for the stomach; controls saliva (spleen and kidney Qi); warms the kidneys to control urine and Jing.

Indications:
• Spleen and kidney cold and Yang deficiency: vomiting, diarrhea, abdominal pain.
• Middle Jiao Qi deficiency: poor appetite, copious saliva (not for excess salivation due to heat forcing out fluid).
• Kidney Yang deficiency: seminal emission, frequent and copious urination, urinary incontinence, dribbling.
• Cold entering the spleen and kidneys: abdominal pain, vomiting, diarrhea.
• Excessive saliva and thick, unpleasant taste in the mouth: Yi zhi ren is better for cold conditions while Pei lan is better for hot conditions.
Yi zhi ren’s spleen-warming properties are more pronounced than its kidney-tonifying qualities. The opposite is the case with Bu gu zhi.
• Crush before use.
Hsu: Stomachic, antidiuretic, inhibits salivation.
DY: With Fu ling to fortify the spleen, secure the kidneys, reduce urination, and stop diarrhea. For indications such as:
– 1. Strangury with chyluria, milky, turbid urine, and dysuria due to deficiency cold in the kidneys or kidney Qi not securing with imbalance in the function of transformation of the bladder. (Use salt mix-fried Yi zhi ren)
– 2. Diarrhea due to deficiency cold of the spleen and kidneys. Particularly watery diarrhea. Use Yi zhi ren which has been stir-fried until scorched.

Dose: 3-9g

Yin Yang Huo – Xian Ling Pi – Epimedium – “Horny Goat Weed”

Nature: acrid, sweet, warm

Enters: Liver, Kidney, (Hong Jin: Spleen)

Actions: Tonifies kidney Yang; eliminates wind-damp; tonifies Yin and Yang to harness rising liver Yang.

Indications:
• Kidney Yang deficiency: impotence, seminal emission, frequent urination, forgetfulness, withdrawal, weak, painful, cold lumbar region and knees.
• Wind-cold-damp: pain or numbness in the limbs, spasms or cramps in the hands and feet, joint pain.
• Liver/kidney deficiency with subsequent liver Yang rising: low back pain, dizziness, menstrual irregularity.
• Sexual effects: increases sexual activity, sperm production, desire; androgen-like effects on testes, prostate and levator ani.
• May possess expectorant and antitussive qualities.
• Watch out for arisal of heat symptoms from use of this herb – contraindicated with Yin deficiency heat. Very drying.
• Particularly useful for Bi syndrome in patients with waning Ming Men fire.
• Often steeped in wine for kidney Yang deficiency or painful obstruction.
Jin: Also warms spleen Yang.
Hsu: Aphrodisiac (stimulates secretion of semen, indirectly promoting sexual desire).
• Hypotensive – dilates peripheral blood vessels, inhibits vasomotor center in the brain.
• Antitussive, expectorant, anti-asthmatic effects.
• Small doses are diuretic, large doses are antidiuretic.

Dose: 6-15g

Notes on This Category

These herbs are commonly combined with:
A. Blood tonics, because blood is the mother of Qi.
B. Herbs that promote Qi circulation – for when there is stagnation (which may be due to Qi deficiency) and also to prevent stagnation as a result of ingestion of these rich herbs.

Bai Zhu – White Atractylodes rhizome

Nature: bitter, sweet, warm

Enters: Spleen, Stomach

Actions: Tonifies spleen Qi; dries dampness; promotes urination; stabilizes the exterior, stops sweating; calms the fetus; resolves water retention and phlegm.

Indications:
• Spleen (or stomach) Qi deficiency with dampness: diarrhea, fatigue, distention in the epigastric region and abdomen, poor appetite, vomiting, constipation.
• Failure of the spleen to transform and transport food: retention of water and dampness: edema, cough, difficult breathing, nausea, vomiting, dizziness, reduced urination.
• Auxiliary herb for damp Bi syndrome.
• Spleen Qi deficiency leading to failure of the Wei Qi to control the pores: spontaneous sweating.
• Spleen Qi deficiency: threat of miscarriage.
• For constipation due to spleen Q deficiency and dampness, use 30g Bai zhu alone.
• Elevates prothrombin time.
• Use raw to dry dampness and promote urination.
• Dry-fry to strengthen the spleen and tonify Qi.
• Scorch to strengthen the spleen and stop diarrhea.
Li: Very warm and dry.
PFGC: Increases the appetite, enhances processing of ingested food.
• Best herb for tonifying spleen Qi (Yang).
• Controls excessive sweating due to spleen dampness.
• Can stimulate sweating because a strong spleen will facilitate sweating if there is a need for it.
• All disorders involving water accumulation and dampness will resolve when the spleen is built up.
Bai zhu should not be used in excessive cold-damp when water pathogens drown the entire central region of the body (must tonify kidney Yang).
• Unprocessed, it can disperse blood between the lumbar region and umbilicus that runs disorderly in the vessels and causes Qi counterflow and internal distress.
• Treats weakness or pain in the extremities caused by a dilapidated spleen.
• With rising and dispersing herbs, it can regulate the liver.
• With sedating herbs, it can nourish the heart.
• With cooling, moistening herbs, it can tonify the Lungs.
• With herbs that moisten Yin, it can tonify the kidney system.
DY: Disperses swelling.
Bai zhu is incompatible with black carp, peaches, plums, coriander, and Chinese cabbage.
• To fortify the spleen and supplement the Qi, bran stir-fried Bai zhu is prescribed. To dry dampness and disinhibit urination, unccoked Bai zhu is used.
• With Fu ling, the two herbs reinforce each other to effectively supplement the spleen and dry dampness, percolate dampness, and disinhibit urination. For such indications as:
– 1. Edema due to accumulation of dampness, due in turn to spleen deficiency. (Bai Zhu San)
– 2. Fatigue, weakness in the limbs, lack of appetite, loose stools or diarrhea caused by spleen deficiency with accumulation of dampness. (Shen Ling Bai Zhu San)
– 3. Vertigo, blurred vision, and/or heart palpitations due to phlegm-dampness. (Ling Gui Zhu Gan Tang)
– 4. Chronic cough due to phlegm-dampness and spleen deficiency. (Liu Jun Zi Tang)
• With Huang qin to clear heat stirring the fetus, dry dampness, and fortify the spleen to contain the blood and the fetus. For uterine bleeding during pregnancy, threatened miscarriage, nausea and vomiting during pregnancy caused by heat or damp-heat associated with spleen deficiency which is incapable of containing the blood within the vessels. For these indications, the Bai zhu should be bran stir-fried, and the Huang qin should be stir-fried until scorched.
• With Zhi shi to supplement without producing stagnation and drain without damaging the correct Qi, to fortify the spleen, disperse food stagnation, and effectively eliminate accumulations and distention. For the following indications, except as otherwise indicated, the two herbs should be stir-fried:
– 1. Accumulation of food, distention and fullness of the abdomen and epigastrium, and difficult bowel movements due to spleen Qi deficiency and Qi stagnation. (Zhi Zhu Wan) When the patient’s main complaint is abdominal and epigastric distention due to Qi deficiency and spleen deficiency with or without dampness, the dosage for Bai zhu should be very high – as much as 100g per day. In this case Bai zhu is generally used alone.
– 2. Splenomegaly and hepatomegaly due to Qi deficiency and stagnation.
– 3. Ptosis of the organs (stomach, uterus, and anus) due to central Qi deficiency. For these indications, honey mix-fried Huang qi, stir-fried Chai hu, and honey mix-fried Sheng ma should be added.
Dong bai zhu is Bai zhu harvested in the winter. Instead of having a drying nature, it has a moistening one. It fortifies spleen Yang and nourishes spleen Yin, moistens the intestines, and treats constipation.
Hsu: Pronounced and long-lasting diuretic effect; sedative; lowers blood sugar; stomachic.

Dose: 4.5-9g

Bian Dou – Bai Bian Dou – Dolichos – Hyacinth bean – Lablab album – “Flat Bean”

Nature: sweet, slightly warm

Enters: Spleen, Stomach

Actions: Resolves dampness; clears summer-heat; mildly tonifies spleen Qi.

Indications:
• Spleen Qi deficiency: loose stool or diarrhea, poor appetite, fatigue, copious leukorrhea, loud stomach growling.
• Summer-heat: especially with vomiting, diarrhea.
• Can tonify spleen Qi without blocking the Qi.
• Can resolve damp without damaging Yin.
• Use dry-fried to strengthen the spleen, untreated to clear summer-heat.
• Some say this herb can nourish spleen Yin.
• Bensky/Gamble: clear summer-heat category.
MLT: Must be cooked – uncooked, it can inhibit the enzymes trypsin and amylase (this effect is significantly but not completely resolved by cooking).
• Eat 50g boiled each day for gastroenteritis.

Dose: 9-21g

Ci Wu Jia – Eleutherococcus senticosus root – “Siberian Ginseng”

Nature: sweet, slightly bitter, warm

Enters: Spleen, Lung, Heart, Kidney

Actions: Tonifies Spleen, Lung, and Kidney Qi; quiets the Shen.

Indications:

• Qi deficiency: fatigue
• Generally indicated for any pain.
• Our understanding of this herb (as discriminated from Wu jia pi) is fairly modern, and largely informed by the Russian research into and use of the herb.
Eric Brand: from this Blue Poppy blog, citing his own Concise Chinese Materia Medica (with Nigel Wiseman)
Boosts qì and fortifies the spleen: Lung and spleen qì vacuity.
Cì w? ji? treats simple patterns of spleen qì vacuity or lung qì vacuity. It not only supplements spleen qì and boosts lung qì, but also dispels phlegm and calms panting.
Dual vacuity of the lung and spleen, manifesting in fatigue and lack of strength, poor appetite, and enduring cough or vacuity panting: Use alone or in combination with medicinals such as w? wèi z? (Schisandrae Fructus), tài z? sh?n (Pseudostellariae Radix), and bái gu? (Ginkgo Semen).
Supplements the kidney: Aching lumbus and knees in kidney vacuity. Cì w? ji? warms and assists yáng qì while strengthening sinew and bone.
Aching lumbus and knees due to insufficiency of kidney yáng depriving the sinews and bones of nourishment: Use alone or in conjunction with medicinals such as dù zhòng (Eucommiae Cortex) and s?ng jì sh?ng (Taxilli Herba).
Cì w? ji? is also used to treat impotence, slowness to walk in children, and wind-damp impediment (bì) patterns with concurrent liver-kidney vacuity.
Quiets the spirit: Heart and spleen insufficiency, manifesting in insomnia or forgetfulness.
Cì w? ji? supplements heart and spleen qì while quieting the spirit and sharpening the wits (improving mental faculties). It boosts qì to engender blood, and is indicated for insomnia or forgetfulness due to dual vacuity of the heart and spleen depriving the heart spirit of nourishment. For this purpose, combine it with medicinals such as hé sh?u w? (Polygoni Multiflori Radix), su?n z?o rén (Ziziphi Spinosi Semen), shí ch?ng pú (Acori Tatarinowii Rhizoma), and yu?n zhì (Polygalae Radix).
BII: Adaptogen: increases humans’ ability to withstand adverse physical conditions, increases mental alertness and work output, increases quality of work under stressful conditions, and improves athletic performance. Also has adaptogenic activity in disease states.
• Virtually nontoxic.
• Useful mainly in fatigue, depression, immunodepression.
PPP: Assists the body to counteract and adapt to stress of many origins; restores and strengthens the body’s immune response; increases vitality.
• Improves mental and physical performance.
• Used to minimize the effects of stress in those subject to chronic illness or to environmental or occupational stress: spares the adrenal glands, promotes self-repair mechanism to enhance resistance to radiation and chemical carcinogens. Compared to Ren shen, Ren shen confers a direct resistance to cells by altering cell physiology whereas the improved survival from eleutherococcus is via an indirect action on the whole organism.
• Used to improve performance and minimize the effects of stress in athletes. In studies, improved speed of runners, maximal work capacity of athletes, and enhanced muscle strength.
• Enhances immune function, especially natural killer cells and T-helper cells. Stimulates immunity against bacteria and viruses.
• May heighten protective activity of the anticoagulant system, improve repair of heart muscle. May provide greater oxygen metabolism and increase conversion of fat into glycogen for energy. May counter the effects of cerebral ischemia. Atherosclerotic patients and those with rheumatic heart lesions show an improvement in cardiovascular function and general well-being when taking eleutherococcus.
• Patients with chronic bronchitis, pneumoconiosis, and pneumonia show improved well-being and Lung capacity when taking eleutherococcus.
• Eleutherococcus lowers blood pressure in hypertension and raises low blood pressure (e.g. in hypotensive children).
• Cancer: Eleutherococcus enhances non-specific immunity and minimizes side effects from radiation, chemotherapy, and surgery, improves healing and well-being.
• Eleutherococcus has been found to inhibit spontaneous malignant tumors and tumors induced by a number of carcinogens. It also led to decreased transplantability of tumors in mice and inhibition of metastases in some cases. Components of eleutherococcus exert an antiproliferative action upon some cancer cells. Eleutherococcus potentiates the effect of some cytotoxic drugs, thereby reducing the amount of drug needed. Eleutherococcus lowered the occurrence of chromosomal mutations and increased the survival rate of plants exposed to mutagens.
• Convalescence after antibiotic therapy: Eleutherococcus has demonstrated a beneficial effect on antibiotic-induced diarrhea during convalescence.
• Adjuvant treatment in dysentery.
• Compared to Panax [true Ginseng]: Unlike ginseng, eleutherococcus rarely causes excitation or a stress-like syndrome in patients. Eleutherococcus has a more general effect on immunity than ginseng. Eleutherococcus causes a more profound increase in stamina than ginseng.
• Caution: sometimes species of Periploca – an inferior and toxic herb – are substituted for eleutherococcus.
• Recommended regime for healthy people is a course of 6 weeks followed by a 2 week break. For treatment of specific illnesses, continuous use is preferable.

 

Dose: 6-30g

Da Zao – Hong Zao – Jujube – Red Chinese Date – “Big Date”

Nature: sweet, warm

Enters: Spleen, Stomach

Actions: Tonifies spleen Qi; nourishes blood; calms the Shen; reduces herbs’ side effects (mild action), moderates and harmonizes the harsh properties of other herbs.

Indications:
• Spleen/stomach Qi deficiency: poor appetite, loose stool, fatigue, shortness of breath (good for children).
• Blood deficiency: mental depression.
• Restless organ disorder: wan appearance, irritability, severe emotional lability.
• Good for eruptions, hives, bleeding.
• Stronger than Gan cao to tonify Qi.
• Closely related to Suan zao ren.
• Seems to normalize the liver (enzymes, recovery from toxicity).
Hsu: Anti-ulcer activity.
DY: Harmonizes and protects the stomach.
• With Sheng jiang to move the defensive Qi, nourish the constructive Qi, harmonize the constructive and defensive, fortify the spleen, and harmonize the middle burner. For indications such as:
– 1. Perspiration, fear of wind, and fever due to disharmony between the constructive and defensive Qi. (Gui Zhi Tang)
– 2. Fatigue, lack of strength, abdominal pain, and lack of appetite due to disharmony between the constructive and defensive Qi. (Xiao Jian Zhong Tang)
– This pair helps insure the proper assimilation of the active principles of other medicinal substances. These are the two main harmonizing herbs in Chinese medicine.
• With Ting li zi to powerfully drain the Lungs, disinhibit urination, and drastically evacuate phlegm without damaging Yin or the stomach. Together, they downbear Qi and calm asthma. For indications such as asthma, cough with stertor, wheezing, a swollen face, and oliguria due to accumulation of phlegm in the Lungs. (Ting Li Da Zao Xie Fei Tang)
Da zao can be used as a harmonizing medicinal with herbs that are incompatible with Gan cao, such as Gan sui, Yuan hua, Da ji, and Hai zao, or in case of edema, anuria, or hypertension.
PCBDP: Emollient, sedative, antitussive, anti-allergic (increases cyclic AMP and GMP in leukocytes), nutritive; may inhibit anaphylaxis; in vitro anti-tumor activity.

Dose: 3-30g (3-12 dates)

Dang Shen – Codonopsis root – “Group Root”

Nature: sweet, neutral

Enters: Spleen, Lung

Actions: Tonifies Lung Qi; tonifies spleen/middle Jiao Qi; mildly nourishes body fluids; mildly nourishes blood.

Indications:
• Spleen Qi deficiency: fatigue, poor appetite, loose stool, lassitude, diarrhea, vomiting, weak limbs, chronic illness, prolapse of stomach, uterus, or rectum.
• Lung Qi deficiency: chronic, weak cough, shortness of breath, weak voice (also with copious sputum due to spleen Qi deficiency).
• Injury of body fluids and Qi in febrile disease: shortness of breath, thirst, wasting and thirsting disorder.
• Blood deficiency: dizziness, sallow face, palpitations.
• Pathogenic influences with significant concurrent Qi deficiency: combine Dang shen with herbs to release the exterior, drain damp, etc.
• Raises RBC count and hemoglobin.
Dang shen is similar to Ren shen, but not as strong. In most cases of Qi deficiency, it can be effectively substituted for Ren shen. In cases of deficiency of both spleen and Lung Qi, it is even preferred. However, Ren shen is imperative for collapsed Qi or devastated Yang. When replacing Ren shen with Dang shen, use about 3 times as much Dang shen as you would use of Ren shen.
• Compared to Yi tang, Dang shen is indicated for deficiency-induced cough with profuse sputum, while Yi tang is more for a non-productive deficiency-induced cough.
• Heiner Fruehauf believes this herb is what was historically used as Ren shen (not ginseng).
• Heiner Fruehauf believes this herb has some potential to exacerbate Gu parasite infections. If the Gu symptoms worsen after administering Dang shen, consider it as a possible cause.
Hsu: Hypotensive; dilates peripheral blood vessels; inhibits adrenal cortex activity.
SD: May help antidote lead poisoning. Has also been widely used for its immune enhancing effects. It is reported to have the same basic action as ginseng, and it is especially good for building up the red blood cells.
DY: Tends to supplement the middle burner and Yin.
• With Huang qi to powerfully supplement the Qi, to effectively supplement the Qi of the middle burner and the exterior defensive. For indications such as:
– 1. Chronic illness leading to Qi vacuity.
– 2. Rectal and uterine prolapse and gastric ptosis due to central Qi fall. (Bu Zhong Yi Qi Tang)
– 3. Lack of appetite, loose stools, fatigue, lack of strength, and spontaneous perspiration due to Qi deficiency.
– 4. Low-grade fever due to Qi vacuity. (Bu Zhong Yi Qi Tang)
– To supplement the middle burner, these two herbs should be honey mix-fried. In case of loose stools or diarrhea, one should prescribe rice stir-fried Dang shen. In case of spontaneous sweats, one should prescribe unprepared Huang qi.
Dang shen does not directly nourish the blood and fluids. It supplements the spleen which is the latter heaven or postnatal root, the origin of Qi, blood, fluids and humors, and acquired essence.

Dose: 9-30g

Feng Mi – Honey (light) – Mel

Nature: sweet, neutral

Enters: Spleen, Lung, Large Intestine

Actions: Tonifies spleen Qi; relaxes muscles to relieve pain; moistens the Lungs, stops coughing; moistens the large intestine, promotes bowel movement.

Indications:
• Spleen Qi deficiency: fatigue, poor appetite, abdominal and epigastric pain.
• Lung Yin deficiency: dry cough, dry throat.
• Large intestine dryness: constipation, especially in the elderly (take 30-60g in warm water or with cucumber).
Li: Honey has a quite cool nature.
• Other sugars: red is quite warm, brown is warm, white is slightly warm or neutral, rock is slightly cool.

Dose: 15-30g

Gan Cao – Licorice root – “Sweet Herb”

Nature: sweet, neutral

Enters: ALL – especially Heart, Lung, Stomach, Spleen

Actions: Tonifies spleen Qi; moistens the Lungs to stop coughing, eases difficult breathing; relaxes the muscles, eases spasms to relieve pain; clears heat; eliminates toxicity; conducts herbs into the twelve channels; coordinates herbs: reduces side effects of some herbs, antidotes some poisons, harmonizes cold and warm herbs, protects the spleen from cold herbs, mitigates the purging function of purgatives and lightens other violent qualities of herbs.

Indications:
• Spleen Qi deficiency: poor appetite, loose stool, fatigue, shortness of breath.
• Spasm and pain in the epigastrium, abdomen, limbs (including when due to malnutrition or cold).
• Fire-toxicity: carbuncles, poisoning from food or herbs, sores, sore throat.
• Used internally and externally to antidote poisons.
• Heat or cold in the Lungs: coughing and wheezing.
• Increases duration and strength of effects of cortisol: useful for low adrenal function.
• Anti-inflammatory effects (glycyrrhetinic acid [weaker than cortisol]).
• Useful for chronic asthma. Used with Ku shen and Ling zhi in the simplified ASHMI formula for asthma.
• Relieves and prevents ulcers (DGL can be used if there is concern of sodium retention and the resulting hypertensive effect).
• May possess anti-neoplastic effects.
• Can cause water retention: aldosterone-like effects, decreased urination, decreased sodium excretion – long-term use may cause hypertension and/or edema.
Zhi gan cao: honey fried – more tonic, better than the raw herb for moderating spasms. This form is used in most cases, except when clearing heat and toxicity (for which the raw herb is preferred).
• Raw Gan cao is more detoxifying and heat clearing than the prepared form.
Gan cao shao: tips of the root – can disinhibit urination and free strangury.
HF: A supplement with an anti-Gu nature, possessing acrid, toxin-resolving qualities, useful in Gu Zheng (Gu parasites) formulas.
SD: May help antidote lead poisoning.
DY: With Bai shao to engender Yin (sour + sweet), calm the liver, fortify the spleen, supplement Qi and blood, harmonize the liver and spleen, soothe the sinews, and stop pain. For indications such as:
– 1. Weakness in the lower limbs and spasms and pain in the limbs due to disharmony between the Qi and the blood which causes inadequate nourishment of the sinews and vessels.
– 2. Abdominal pain due to liver-spleen disharmony. If either disorder is accompanied by cold signs, use wine mix-fried Bai shao and mix-fried Gan cao. If the disorder is accompanied by heat signs, use raw Bai shao (or Chi shao) and raw Gan cao.
– 3. Headaches due to blood deficiency. (Add He shou wu, Bai ji li, and Jiang can.)
• The combination of Bai shao and Gan cao is very effective for numerous problems accompanied by spasms and pain, such as gastritis or colitis, spasm of the gastrocnemius muscle in the leg, contraction of the limbs, tendinitis, lateral costal pain, and hiccups or stubborn vomiting caused by spasm of the diaphragm.
Gan cao can moderate the cold nature of Hua shi and protect the middle jiao, while Hua shi can prevent stasis due to the sweet flavor of Gan cao. As a pair, they clear heat, eliminate summer-heat, disinhibit urination without damaging the middle burner, and free strangury. For such indications as:
– 1. Fever, vexation, agitation, thirst, vomiting, diarrhea, and dysuria due to attack of summer-heat with internal and external heat. (Liu Yi San)
– 2. Turbid strangury.
– 3. Stone and/or sand strangury.
– For these indications, Gan cao shao is superior to regular Gan cao.
• With Jie geng to clear heat, transform phlegm, disinhibit the throat and stop pain, evacuate pus, and resolve toxins.
– 1. Pulmonary abscess with cough, expectoration of profuse, purulent phlegm, and chest oppression and pain due to heat stasis in the chest. (Jie Geng Tang)
– 2. Pain, redness, and swelling of the throat due to heat (deficient or excess, external or internal).
– 3. Loss of voice and/or hoarse or husky voice.
– For indications 2 and 3, the combination can be reinforced by adding He zi, as in He Zi Tang. For these indications, in cases of Lung dryness, honey mix-fried Jie geng should be used.
Gan cao is incompatible with pork, seaweed (particularly Hai zao), and Chinese cabbage.
• In cases of edema, oliguria, anuria, or hypertension, the dosage of Gan cao must be moderate (3-6g) and its administration should be of short duration. In other cases, for prolonged administration, a dosage of 10g per day should not be exceeded.
• Note: Sionneau lists the usual dosage of Gan cao at 6-10g.
K&R: Anti-inflammatory, anti-allergic, immune strengthener, estrogenic, luteotropic, antispasmodic, antiulcerative, vagolytic, febrifuge, antitussive, aldosterone stimulant, MAOI, stimulates the adrenal cortex.
• Improves fat digestion, reverses degeneration of liver cells by improving detoxification – for fatty liver, chronic hepatitis, to lower cholesterol.
• Increases interferon production.
• Eye drops: for conjunctivitis, blepharitis.
• Chronic gum infections.
• Prolonged use is suitable only for the water yin type (since it can lead to K+ loss and edema).
• Earth, water, and metal yin.
Earth: GI ulcer and spasm, glossitis, stomatitis, herpes simplex infection, tooth plaque.
Water: low immune function, depression, chronic infection, gonadal insufficiency, trichomonas infection.
Metal: recurring, chronic respiratory tract infection, cough.
BII: Heals peptic ulcers (DGL preferred), estrogenic activity, aldosterone-like action (can cause sodium retention and hypertension – a high potassium, low sodium diet may prevent this), anti-inflammatory (cortisol-like action), anti-allergic, antihepatotoxic, antineoplastic, expectorant, antitussive, antiviral.
• Possible use in: HIV (seems to halt progress of the disease, may prevent decline of CD4s and CD8s), aphthous stomatitis (mouthwash), eczema, heartburn, hepatitis, inflammation, menopausal symptoms, periodontal disease.
JC: Aperient, demulcent, emollient, pectoral, slight stimulant, sialogogue, expectorant.
• Laxative or mildly purgative (by dose) to the entire intestinal tract: a moderate dose makes liquid stools within 3-12 hours (3-6 on an empty stomach).
• Useful for hemorrhoids.
• Healing to the glandular system.
• Heals mucous membranes.
Yoga: Yashti Madhu (honey stick): V, P-; K+(if used long term)
• Demulcent, expectorant, tonic, rejuvenative, laxative, sedative, nourishes the brain, increases cerebrospinal fluid.
Sattvic – calms the mind, nurtures the spirit.
• A large dose is a good emetic for cleansing the Lungs and stomach of Kapha.
Hsu: Detoxifies bacterial toxins, poisonous foods and drugs, toxins of metabolic products.
• Antispasmodic, inhibits gastric secretions caused by histamine, anti-inflammatory, antitussive, antiallergic, antiulcerative, expectorant, adrenocortical hormone-like effects.
HF: (The words of Zhang Xichun:) If processed, the tonic properties of licorice become enhanced, while if left unprocessed, it not only tonifies the center, but also disinhibits. It is therefore appropriate for the treatment of cholera. The theory that raw licorice has a disinhibiting effect can easily be proven in clinical practice. I once treated the child of a Mr. Wang from Kaiyuan. Endowed with a weak spleen and stomach, the boy suffered from serious indigestion and kept throwing up his food. Also, his urination was inhibited, producing edema in virtually every part of his body, as well as a large and distended belly. I prescribed fine licorice powder, to be mixed with an equal amount of the Western drug Pepsinum. I had him take one qian (3g) of this mixture three times per day. After several days, the vomiting stopped, the urination returned to normal, and the swelling and distention disappeared.
My friend Wei Ziba made it a habit to put some licorice in his teapot every day, pour hot water over it, and drink it like a tea. After about ten days, he noticed that both his stool and his urination started to get quite busy, and he stopped drinking the licorice water. When he saw me later, he related this to me and asked why an herb that is usually thought of as a tonic can disinhibit urination and bowel movements. I answered: “When cooked or processed, licorice tonifies; when used unprocessed, it disinhibits. Even though you put the herb into a teapot with hot water, it never got cooked. Therefore, its effect was still close to the raw herb, and therefore could disinhibit.”
Li Zibo told the story of a child suffering from abdominal pain. The doctor said that frequent consumption of licorice decoction could cure the problem. Because the patient drank too much of the licorice decoction, urination became inhibited and symptoms of edema and abdominal distention emerged. The boy lived close to the train station, where there were always wagons loaded with licorice. His sister often brought some of it home so they could chew on it, and as this became a daily habit, his edema and distention gradually disappeared.
These examples demonstrate that the functions of unprocessed licorice and processed or cooked licorice are fundamentally different. When working with licorice, therefore, shouldn’t we always consider the raw or processed/cooked state of the herb as an integral part of the prescription?
CHA: (Karen S Vaughan, 11-17-2000):
As far as I can determine blood pressure has never been known to be raised from properly prescribed herbal preparations containing licorice root, of either the European or Chinese varieties. It has however been found to be raised in persons consuming large quantities of (real) licorice candy such as Panda licorice, at doses as low as 1 ounce candy daily and can also be attributable to (real) licorice flavored alcoholic drinks. Candy consumption and extrapolation from constituent data are the root of warnings about licorice and blood pressure. Quantity and refinement issues are both factors with licorice candy. There is a significant difference in aqueous extractions and alcohol extractions in licorice. My information is that one would need 10-45 grams per day [to raise blood pressure], which is a lot of licorice. There are cases of persons who have unusual sensitivity (almost allergy) to licorice, plain or DGL which may manifest with high blood pressure. I find oedemic, not diuretic indications for licorice in my western sources. Reduced excretion of potassium (and its replacement) can be achieved with the addition of dandelion to formulas. Some constituent information which may or may not be relevant to aqueous extractions of Gan cao: One active ingredient in licorice, glycyrrhizin, and it main gut metabolite in humans, glycyrrhetic acid, both prolong the effects of cortisol, by creating an aldosterone-like agonist effect, thereby causing sodium retention and potassium depletion at the distal tubule in the nephron. Those on blood pressure medicines such as Lasix (furosemide) or hydrochlorothiazide, heart medicines such as Lanoxin (digoxin), or cortisone-type drugs, including prednisone may be susceptible to cross-reactions from constituents in licorice, especially in concentrated extracts, candy or licorice liqueurs. For over forty years, glycyrrhizin has been a prescription drug in Japan to treat inflammatory illnesses such as ulcers and chronic liver disease. It is also used to decrease allergic reactions to other drugs. Glabridin, which is not water extracted, but may be present in other preparations, has strong antioxidant properties. Researchers using a highly refined licorice extract suggest that chemicals in glycyrrhizin called triterpenoids may be effective against cancer. They may block the production of a prostaglandin that may be responsible for stimulating the growth of cancer cells – and help get rid of cancer-causing invaders. Triterpenoids have been shown in test tubes to stunt the growth of rapidly multiplying cells, like cancer cells, and they may even help precancerous cells return to normal. Glycyrrhetic acid is also antitumoral in low doses in estrogen sensitive cancers, operating by tying up estrogen receptors. Large doses(> 300mg extract, >2 gm powder, or >4 ml fluid extract) of licorice may, however, show more of the estrogenic effects due to the higher availability of the isoflavones. The antagonistic effects occur by competing for receptor sites, but once all empty sites are filled, there is no greater antagonistic effect. There is some early indication for use in AIDS treatment but the research is difficult to interpret accurately. The American species (Glycyrrhiza lepidota) does not share the potential for blood pressure elevation in concentrated doses that European and Asian species have.

Dose: 2-12g

Huang Qi – Astragalus root – Milk-vetch

Nature: sweet, slightly warm

Enters: Spleen, Lung

Actions: Tonifies spleen Qi and Lung Qi; lifts spleen Qi (raises the Yang Qi of the spleen and stomach); tonifies defensive (Wei) Qi; protects/stabilizes the body surface and eliminates pathogenic factors from the surface; discharges pus; promotes tissue regeneration; promotes urination, relieves edema; regulates water metabolism; nourishes blood (via Qi); can connect the Lungs and spleen.

Indications:
• Lung and spleen Qi deficiency: poor appetite, loose stool, fatigue, shortness of breath.
• Spleen Qi sinking: chronic diarrhea, uterine bleeding, prolapsed rectum, stomach, or uterus.
• Wei Qi deficiency: spontaneous sweating, frequent EPI’s.
• Qi and blood deficiency: non-healing carbuncles, boils, post-partum fever; also used in recovery from severe loss of blood.
• Spleen failing to transform and Lung failing to dominate the water passages: edema, scanty urination, retention of water, dampness, obesity.
• Used often for wind-stroke (with Hong hua, Dang gui, Chuan xiong).
• When appropriate: for wasting and thirsting, paralysis, numbness of the limbs.
• Chronic ulcerations or sores due to deficiency that have formed pus but have not drained or healed well.
• Appropriately combined, it may be used for excessive sweating associated with Qi, Yin, or Yang deficiency.
• Its function to stabilize the exterior may be used to produce a therapeutic sweat when diaphoretics do not work.
• Vasodilator: lowers blood pressure.
• Compared to Dang shen and Ren shen, Huang qi focuses more on the superficial aspects of the Qi (especially Wei Qi), is better for warming and raising the Qi and tonifying the Qi to improve metabolism, whereas Dang shen and Ren shen focus more on the source Qi. Tonification is more complete when these substances are used together.
• Fry (dry or with honey) to focus the herb’s action on tonifying Qi and raising Yang (rather than securing the exterior, promoting urination, and reducing swelling).
Liu tends to use a minimum of 30g per day.
Chinese Traditional Herbal Medicine Vol.II Materia Medica and Herbal Resource: When combined with Gan cao, it regulates blood sugar – useful for both diabetes and hypoglycemia.
Heiner Fruehauf: A supplement with an anti-Gu nature, possessing acrid, toxin-resolving qualities, useful in Gu Zheng (Gu parasites) formulas.
Botanical Influences on Illness: A Sourcebook of Clinical Research: Enhances T-lymphocyte function, may enhance macrophage phagocytic function, increases NK cell activity.
Pearls From the Golden Cabinet (Subhuti Dharmananda): Unprocessed: fortifies the surface: will bring sweat if there is none (when the body is too weak to expel pathogens), and will astringe sweat if there is too much (by stabilizing the surface).
• Processed: produces blood, generates muscles, accelerate formation of (transformation of toxins into) and expulsion of pus – good for boils.
• Purely Yang in nature – best for the surface, Yang-collapse, weak eruptive force behind skin problems. Ginseng is more for water exhaustion and problems of Qi diffusion, while astragalus is more for fire exhaustion with the inability of Qi to reach the upper and outer regions of the body.
Oriental Materia Medica: A Concise Guide: Effective for nephritis, especially in treating proteinuria.
• Vasodilator, improves blood circulation to the skin, antibacterial, hypotensive, diuretic.
Dui Yao: The Art of Combining Chinese Medicinals: Fills the interstices; secures the exterior; fluid and mobile.
• With Dang gui to supplement the Qi to strongly engender and transform blood, to effectively supplement the Qi and blood. For the following indications, wine mix-fried Dang gui and honey mix-fried Huang qi should be used. Also, the whole Dang gui root (Quan dang gui) or the body of Dang gui (Dang gui or Dang gui shen) should be used. The dosage of Dang gui for the following indications should be relatively low if there is Qi deficiency and weakness in the middle burner.
– 1. Delayed menstruation (a long cycle), postpartum weakness, agalactia due to Qi and blood deficiency. (Shi Quan Da Bu Tang)
– 2. Low-grade fever caused by blood deficiency. (Dang Gui Bu Xue Tang) Wu Kun of the Ming dynasty said, “When the blood is full, the body is cool. When the blood is vacuous, the body is warm.”
– 3. Sores and welling abscesses that do not heal, due to blood and Qi deficiency. (Tou Nong San)
– 4. Numbness of the limbs due to deficient blood not nourishing the sinews.
– 5. Various hemorrhages due to Qi not containing the blood within the vessels. (Dang Gui Bu Xue Tang)
• With Fang feng to supplement the defensive Qi without retaining external evils in the body, to drain external evils without damaging correct Qi and without causing perspiration, to secure the exterior, prevent invasion by external evils, and stop perspiration. This combination appears in Yu Ping Feng San for indications such as:
– 1. Spontaneous perspiration due to exterior deficiency.
– 2. Tendency to contract EPIs frequently due to defensive Qi deficiency.
Yu Ping Feng San should not be used to treat wind affections that are already established. This combination is too astringent once the evil Qi and the defensive Qi are already struggling. Its use might, in this case, retain the external evil inside the body.
– The pair Fang feng and Huang qi, when combined with Zhi ke, yields good results in the treatment of prolapse of the rectum, external hemorrhoids, flatulence, and abdominal distention. For rectal prolapse, the best approach is to add 3g Fang feng and 6g Zhi ke to Bu Zong Yi Qi Tang.
• With Dang shen to powerfully supplement the Qi, to effectively supplement the Qi of the middle burner and the exterior defensive. For specific indications and notes, see Dang shen in this category.
• With Fu xiao mai to supplement Qi, nourish the heart, clear heat, secure the exterior, and stop perspiration. For indications such as spontaneous sweating due to exterior deficiency. (Mu Li San) Use stir-fried Fu xiao mai.
• With Fu zi for mutual reinforcement, to supplement the Qi and warm the Yang, return Yang, secure the exterior, and stop perspiration. For indications such as cold spontaneous perspiration accompanied by aversion to cold, cold limbs, lassitude of the spirit, a pale tongue with white fur, a fine, weak pulse, and in severe cases, profuse sweating, loss of consciousness, and a minute pulse due to Yang deficiency or Yang collapse.
• With (Han) Fang ji to simultaneously drain and supplement, to support the correct Qi and drain evil Qi at the same time, to regulate the upbearing and downbearing of the Qi mechanism and strongly promote diuresis. For the following indications, the combination is found in Fang Ji Huang Qi Tang:
– 1. Edema due to wind-water with fever, fear of wind, edema predominantly in the upper body and face, joint pain, scanty urination, and a floating pulse. If wind attacks the exterior and blocks the Lung Qi, this causes a disturbance in the Lungs’ diffusing and downbearing function. Therefore, because the water passageways are not regulated, dampness is not moved downward. Thus, there is accumulation of dampness in the upper body and edema appears.
– 2. Rheumatic pain due to damp Bi with heavy limbs, joint numbness, and sometimes swollen joints.
– 3. Chronic nephritis and cardiac disease with edema due to Qi deficiency and accumulation of dampness.
• With Mu li to supplement Qi, constrain Yin, secure the exterior, and stop perspiration. For indications such as:
– 1. Spontaneous perspiration due to Qi or Yang deficiency. (Mu Li San) Use calcined Mu li.
– 2. Night sweats due to Yin deficiency. (This combination is appropriate for moderate Yin deficiency. In cases of deficiency fire, this pair cannot be used alone.)
– 3. Spontaneous and nighttime perspiration due to Qi and Yin deficiency. (Mu Li San) Use calcined Mu li.
Huang qi pi is outer bark of Huang qi. It has a greater affinity than Huang qi does for the exterior, and is more potent for securing the exterior, stopping perspiration, disinhibiting urination, and treating edema.
Subhuti Dharmananda: Astragalus root (huangqi) is a commonly used Chinese herb from the Fabaceae family (legumes). It belongs to the subfamily Papilionoideae, which is the source of several popular Chinese herbs, including licorice (gancao), millettia (jixueteng), sophora (kushen), and pueraria (gegen).

The applications of astragalus underwent dramatic changes during the past 50 years because of two medical concerns: the increasing use of chemotherapy for cancer, in which case herbs to counter the immune-debilitating effects were sought, and the rise of cardiovascular diseases (e.g., heart attack and stroke). For the former, the combination astragalus with ligustrum (nüzhenzi) was most publicized due to involvement of Western investigators; for the latter, the combination of astragalus with salvia (danshen) became well known.

A look at the use of astragalus before the influences of these modern trends is offered by Smith and Stuart (1), who reported at the end of the 19th century that astragalus was “in great repute as a tonic, pectoral [alleviates disorders of the lungs and chest], and diuretic medicine…every sort of wasting or exhausting disease is thought to be benefited by it.” At that time, a frequently occurring wasting disease involving the lungs was tuberculosis, and the herbal therapies usually included astragalus. The original description of astragalus in the Shennong Bencao Jing (ca. 220 A.D.) would be hardly recognizable for someone who learns of this herb from modern literature:

It mainly treats welling and flat abscesses and enduring festering sores by expelling pus and relieving pain, great wind lai disease [leprosy], the five kinds of hemorrhoids, and “mouse fistulas.” It supplements deficiency and is good for hundreds of diseases in children.

The herb was used to treat skin disorders, superficial swellings, and children’s ailments. The editors of the modern translation quoted here (2) no doubt felt compelled to offer some information that is more in keeping with the current applications of astragalus and added a footnote quoting from Wang Haogu, an herbalist of the Jin-Yuan reform period (3), more than 700 years ago: “Astragalus replenishes the defensive and, therefore, is a medicinal for the exterior. It boosts the spleen and stomach and, therefore, is a medicinal for the center. Since it is able to treat cold damage with the cubit pulse not arriving, it supplements the kidney origin and, hence, is a medicinal for the internal.” Through this explanation, astragalus is seen as a broadly useful tonic ingredient to include in prescriptions.

A substantial number of traditional formulas indicated primarily for tonification that come to us today contain astragalus, though it may be included as a small proportion of the prescription. As an example, in the tonic section of Thousand Formulas and Thousand Herbs of Traditional Chinese Medicine (4), over 80 prescriptions are listed, including four of the ones in the above table (Yupingfeng San is placed with astringent formulas instead); about one in four of all the tonic formulas contain astragalus as an ingredient.

Two of the traditional formulas with astragalus have been adopted for modern use as “immune enhancing” prescriptions, sometimes given to patients undergoing cancer therapies: Buzhong Yiqi Tang and Shiquan Dabu Tang.

IS ASTRAGALUS STRONG OR MILD?

Some practitioners may think of astragalus as a “strong” qi invigorating herb because of its frequent use in tonic formulas; however, most traditional sources place it in a mild to intermediate category. Yang Yifan, in her book on Chinese Herbal Medicines: Comparisons and Characteristics (5), displays a scale of strength of qi tonics and places astragalus well below ginseng, but slightly above codonopsis (dangshen). In the Advanced Textbook on Traditional Chinese Medicine and Pharmacology (6), astragalus is listed with two other herbs, ginseng and codonopsis, as tonics that have the similarities of replenishing qi of the spleen and stomach. As to differences, ginseng is described as being able to “replenish primordial qi potently,” codonopsis is described as have properties similar to ginseng but with much weaker effect, and astragalus is described as “consolidating superficial defensive qi.” So, in terms of qi tonics, ginseng is considered potent, codonopsis is relatively weak, and astragalus is somewhat stronger than codonopsis, but aimed at the surface defense while codonopsis and ginseng, act on the primordial (original) qi.

There are some characteristics that may be associated with mild versus strong herbs. Mild acting herbs have these qualities: low toxicity; low incidence of adverse reactions at normal dosage; and the normal dosage is relatively high. As a contrast to mild acting herbs, there are those that have notable toxicity (such as raw aconite), those that easily cause adverse reactions (such as rhubarb causing intestinal cramping or loose stool), and those that have significant effects at low dosage (e.g., the potent heating effect of zanthoxylum at just a gram per day). Astragalus clearly fits the category of mild-acting herbs. It has a gentle warming nature, a mild, sweet taste, and can be used in doses of 30 grams or more without adverse effects. Laboratory animal studies show virtually no toxicity with administration of very high oral dosage or even with injections (7).

ASTRAGALUS INGREDIENTS AND ACTIONS

After several decades of study, three groups of active constituents have become known for astragalus: flavonoids (which give the yellow color to the root slice), saponins (a common ingredient of plants in this family), and polysaccharides (long-chain polysaccharides with potential medicinal benefit mediated by white blood cells). The quantities of these components will vary depending upon the species of Astragalus used, as well as the growing conditions and other factors. No other potential active constituents have been found in significant quantities. Of course, there are many other components of astragalus root, but they are either ordinary components found in foods (such as carbohydrates and proteins) or ingredients that are present in such small amounts as to not contribute significantly to the effect of the whole herb preparations even when the herb is used at high dosage (e.g., sterols). Those who have used astragalus root in decoction recognize that it is a very fibrous root, for which most of the material remains behind in the dregs after prolonged boiling.

FLAVONOIDS

Astragalus contains small amounts of several flavonoids, primarily isoflavones, such as formononetin (see image, below) and its glucoside, ononin, which are metabolized in the body to yield the common legume flavonoid daidzein, an ingredient in pueraria and soy beans. Flavonoids are found in all higher plants, but some plants are rich sources of them. In fact, pueraria root has flavonoids as the primary active ingredient (aside from its starches that are soothing to the gastro-intestinal system). There are numerous potential beneficial effects of flavonoids (8), but when present in modest amounts, as is the case with astragalus, the primary effect is to benefit circulation. Other actions, that are noted for high doses of flavonoids, such as anti-allergy and anti-viral activity, would not be expected from astragalus extracts.

In one recent study (9) it was noted that “In the roots, isoflavonoid content was extremely variable, but reached 3.04 mg/gram, whereas flavonol content was 0.49 mg/gram.” Modern supplements that provide flavonoids such as quercetin for therapeutic benefit have several hundred milligrams making up a one day dose, while isoflavones in soy and clover (which are essentially the same as found in astragalus), are reputed to help with menopausal symptoms and have other benefits at doses of 60-180 mg or more per day. The combined isoflavonoid and flavonol content mentioned here (using the figure given for the maximum) is 3.5 mg/gram (0.35%), so that a 15 gram daily dose of astragalus in decoction would yield only about 50 mg of these flavonoids if all were extracted. This is a small amount, and most roots have lower levels of the flavonoids, typically less than 0.1%. In commercial extracts, standardization of astragalus root concentrate is for the product at just 0.4-0.5% of the main isoflavone, a tiny amount. The astragalus flavonoids contribute the yellow color seen in the central part of the roots, which is frequently used as a monitor of root quality (those with stronger yellow coloration are considered better quality).

In sum, though the flavonoids may contribute to a general beneficial effect of astragalus, their effects are probably minor until the astragalus dosage exceeds 15 grams, as is common in modern clinical practice in China, but not as herbs are usually prescribed in the West. In the book Chinese Drugs of Plant Origin (10), flavonoids are not included in the list of astragalus active constituents; only the saponins and polysaccharides are included.

SAPONINS

The saponins of astragalus include several called astragalosides (-oside indicates that it is a glycoside, that is, has a sugar attached to an active molecule, such as a pentacyclic compound usually found in saponins). In a study of astragalus roots from China, the saponin content was found to be from 0.019 to 0.184%, with astragaloside I as the main component (10); others consider that astragaloside IV is the main component (see image, below). When astragalus extracts are made and standardized for saponin content, a 0.5% saponin level is the most that is usually attained (one Chinese source indicates a range of 0.2 to 20% saponin content available). In a previous analysis of saponin-containing herbs, it was shown that to get substantial activity for these compounds one would need to administer doses of 60-900 mg (11). Based on a maximum root content of about 0.184% saponins, a 15 gram daily dose of astragalus might yield about 28 mg total saponins, a small amount. These saponins of astragalus, if they were given in sufficient quantity, may have properties of reducing inflammation, resolving phlegm, reducing platelet sticking, and promoting cardiac function.

Ginseng (renshen) is an herb that has saponins as its primary constituent, and good quality red ginseng roots can have about 4-5% saponins in the dried material; extracts may have up to 85% saponins. Thus, the ginseng saponins are easier to get in reasonable quantities. An herb that is used like astragalus for treating abscesses and certain other skin diseases is platycodon (jiegeng); it also relies on saponins as a key active component, but it contains even more saponin than ginseng, usually over 6% in the dried roots. A traditional formula for treating abscesses that relies on both astragalus and platycodon is Qianjin Neitou San; the formula also has saponins from ginseng and licorice.

In sum, the saponins in astragalus may be present in small enough quantities that they don’t provide much therapeutic effect on their own. However, when astragalus saponins are combined with saponins from other herbs in a formula, they may contribute to getting the necessary amount for the desired therapeutic effect.

POLYSACCHARIDES

The polysaccharides of astragalus, called astragalans, may be present in relatively large quantity. It is important to recognize that polysaccharides (long chains of sugars; see image of a repeating structure, below) are not soluble in alcohol, so are not present in tinctures or other alcoholic preparations; they are soluble in hot water, but the desired high molecular weight ingredients (20,000-25,000 daltons) may be only partially extracted from the herb under normal conditions. It is relatively easy to isolate polysaccharides by first using hot water extraction and then condensing these large molecules out of solution with alcohol. Commercial astragalus extracts have been standardized to 40-50% polysaccharides; some sources claim ability to provide 70-90% polysaccharides. These levels are as high as attained with mushrooms that are used specifically for their polysaccharides (typically 40% polysaccharides in the standardized extracts, but sometimes higher percentages). A reasonable estimate for the content of the dried roots is about 10% extractable medicinally active polysaccharides (in one of the most commonly used commercial astragalus extracts made by hot water extraction, the concentrated material has just 16% polysaccharide and 0.2% flavones). The crude powdered herb may be a better source of polysaccharides than a boiled preparation, but a polysaccharide rich extract is the most convenient means of getting high doses of this component.

In a previous analysis of medicinally active polysaccharides and their applications, it was shown that a daily dosage of 3.0-3.5 grams of these components would be reasonable to attain some level of immunological activity (12). A 30 gram dose of astragalus would have about this amount of polysaccharides. The polysaccharides have the reputation of enhancing immune functions and specifically in improving white blood cell responses; the large molecules probably stimulate the white blood cells to respond just as they might to saccharide chains on the surface of bacteria; there may also be a stimulation of white blood cell production by the bone marrow. Polysaccharides have been used, especially, in attempts to overcome the immune debilitating effect of radiation and chemotherapy as used in cancer treatments. In China, astragalus is most often used in doses of 15-30 grams per day in decoction for this application.

It appears that the polysaccharides are present in sufficient quantity that the high dosage astragalus preparations could affect the white blood cell activity.

DOSAGE AND EFFECT

The analysis of active constituents present above reveals that a dose of about 15 grams of astragalus, as frequently used in decoctions, may be sufficient to attain only some of the desired effects of the known active components, but that a 20-30 gram dose would be more suitable.

The Chinese Materia Medica recommendations for astragalus dosing are 9-15 grams/day (with the understanding that astragalus is to be used in formulas with other herbs); high doses of 30-60 grams are also suggested, at least for some applications (usually not specified). When dosing at or below 15 grams, an herbalist is counting on other herbs in a formula to contribute some similar active components in order to get the desired therapeutic action. Thus, for example, a decoction made with astragalus, ganoderma (lingzhi), and red ginseng would provide polysaccharides and saponins from all three herbs, and so long as the total dosing of these three ingredients was sufficient, then astragalus at 9-15 grams/day would be acceptable.

The formula Yiqi Congming Tang has three botanically-related herbs-astragalus, licorice, and pueraria-all contributing flavonoids and saponins, as well as having ginseng with additional saponins. Thus, astragalus is not the sole herb relied on for these active components. This formula is not used for immune enhancing purposes, so the limited amount of polysaccharides from other ingredients is not a concern.

Lower doses of astragalus would not be entirely ineffective, but the action would be limited. As an example, the polysaccharides can have benefits for the stomach (e.g., alleviating ulcers) at doses below that necessary to yield the general immunological effects, because of the direct action of the full amount of the herb ingredients on the stomach before being distributed throughout the body. Thus, pills with a relatively small amount of astragalus included will have this type of action from astragalus. Following absorption from the small intestine, the astragalus ingredients are diluted into a large volume of blood and some begin to be metabolized and eliminated after just a few minutes.

The recommended high doses of astragalus, at 30-60 grams per day (sometimes as high as 120 grams/day), are used in short-term therapies to get a stronger action of the herbs, and this dosage should yield a substantial effect from both the saponins and polysaccharides, with some effect also from flavonoids. It is not known if prolonged use of these higher dosages could be detrimental, but a reasonable caution would be to limit the duration to a few days at a time when needed, rather than a continuous therapy.

TRADITIONAL INDICATIONS FOR ASTRAGALUS

In the book Chinese-English Manual of Commonly Used Herbs in Traditional Chinese Medicine (13), five major actions and associated uses are given, as well as some miscellaneous new uses (item 6):

Invigorate qi and spleen (poor appetite, loose stools, fatigue, and bleeding).
Invigorate qi to activate yang (prolapse of stomach, uterus, or rectum)
Invigorate qi to strengthen the body (common cold in debilitated patients, profuse sweating due to weakness)
Relieve skin infection and promote tissue regeneration (abscesses, skin erosion, unhealthy wound); also for erosion of stomach lining (ulcer, atrophic gastritis)
Promote diuresis and relieve edema (spleen-deficiency type edema).
Miscellaneous new uses: diabetes, hemiplegia, asthma, and leukocytopenia (low white blood cells); astragalus is indicated for these disorders in cases of qi deficiency or qi and yang deficiency.

It is important for practitioners to distinguish between traditional indications (some of which are based solely on dogma and not on careful observation) and known effective actions (which might be confirmed through clinical trials). For example, it would be a mistake to think that a prolapsed organ would go back into place merely by taking some astragalus or by using this herb in a qi tonic formula. This indication for astragalus comes from three considerations:

A prolapse indicates muscular weakness; the muscles are ruled by the spleen qi, becoming weaker with reduced qi; astragalus is a spleen qi tonic.
A prolapse represents a falling of an organ from its place; the upward flow of qi is promoted by herbs that invigorate qi and yang, hence astragalus is appropriate in that its “direction” of action is upward against the fall of the organ.
Since a prolapse often produces a heavy sensation and fullness or swelling where the organ has moved, the syndrome is like one of moisture accumulation; herbs that remove dampness, such as astragalus, may help.

These theoretical reasons for using astragalus are consistent with Chinese medical theory, but there is no evidence to show that the appropriateness of astragalus in this instance corresponds to its effectiveness in alleviating prolapse. Indeed, in order to reverse prolapse non-surgically, one usually needs to strengthen the muscles surrounding the organ, which requires doing physical exercise. If taking herbs will, by whatever mechanism, improve one’s sense of energy and capability, then the person might undertake more exercise. That added activity would, in turn, control or reverse the prolapse through strengthening the muscles. If the herbs do not aid one in pursuing the physical activity, they would be unlikely to have any substantial impact on the prolapse, other than alleviating discomfort.

While an analysis of each of the claimed activities for astragalus is beyond the scope of this article, it can be said that those which directly affect digestion, such as treating low appetite, loose stool, stomach ulcer, and atrophic gastritis, may be partly explained by direct action of the ingredients on the lining of the stomach and intestine. Saponins and polysaccharides are likely to be the main active components, potentially of benefit in small doses in contact with the stomach lining. Resolving skin infections and erosion, aiding treatment of common cold, and promoting while blood cell function are actions that would require the higher dosages discussed above. Claimed diuretic effect of herbs is an area of some difficulty to interpret, as the drinking of decoctions is, in itself, a potential means of diuresis because of the fluid consumed. Further, the body’s elimination of the chemical constituents contained in the herbs and their metabolites is primarily by diuresis. A diuretic effect may be stimulated by high levels of such chemical compounds, with relatively little specific diuretic action of the herbs included in the therapy. Low dosage pills are unlikely to have much diuretic effect, both because of the low dose and because of the lower fluid intake (unless they are swallowed down with a large amount of water or tea).

Astragalus can be an effective agent, though one must give due considerations to its preparation and dosage according to the intended application, and the practitioner must be careful about interpreting indications that appear in the traditional literature.
Huang Huang:
I. Functions

  • A. Supplement qi, strengthen the exterior, dissipate edema.
  • B. Areas of function: metabolic system, immune system, cardiac and cerebralvascular system
  • C. Treats: sweating with edema, able to eat but lack strength
  • Caveat: too much Huang Qi causes distention, can exacerbate gallstones problems.
  • The taste of Huang Qi is bean-like, it is in that family; good quality is nice and soft; it has a 3000year history of use. In Shennon Bencao Jing it is a superior class herb. It is commonly used in China. Huang Qi vs. Zhi Huang Qi: Dr. Huang does not believe Zhi Huang Qi is more supplementing than Sheng Huang Qi; one can just use the unprepared, it is actually better. Dr. Huang feels only toxic herbs should be prepared.
  • Use: What do you use it for? Spleen and Lung qi xu, but in what situation, what symptoms and patterns?

II. Patterns

  • A. Sweating
  • 1. Spontaneous sweating: relatively severe with the clothes often becoming completely soaked and with sweat stains that sometimes have a yellowish color.
  • 2. May sweat worse when eating, with significantly more sweating from the upper portion of the body.
  • 3. In addition to spontaneous sweating in the daytime, may be night sweats, wake to find entire body soaking wet as if immersed in water.
  • 4. Sometimes does not manifest with a significant amount of spontaneous sweating. However, patient usually prone to some type of sweating: readily sweats on minimal exertion, history of spontaneous or night sweating.
  • B. Edema
  • 1. Generalized edema, but worse in the lower body.
  • 2. Easy to develop. These types after long flight feet would swell. If get fatigued, walk a lot, or have salty meal it is easy for them to develop edema.
  • 3. Mornings the facial swelling is worst, but by afternoon, lower legs are worst   4. In some patients, edema is not pronounced, but flesh is soft so they appear like they have edema.
  • 5. Because of accompanying edema, often a subjective sense of the body feeling heavy and uncoordinated. Associated with discomfort, joint pain, hard to walk, a lot of fatigue, athletes must clear fluid to be comfortable. Huang Qi promotes urination.
  • 6. May also be heaviness and pain in the joints.
  • Case History: Patient had generalized edema and asthmatic breathing. Physician gave him 120g Huang Qi with congee, patient urinated copiously, edema lessoned significantly. Edema in upper body eliminated, but foot remained swollen. Sent patient back home, another doctor gave him a purgative for swollen feet, all the swelling came back with fatigue. He was debilitated, doctors felt this was intractable, thought he would die. His wife realized he was still breathing, she made up the first formula, he started urinated again, and little by little he recovered. This first formula is used commonly and successful.
  • Case History: Fan Hou Case History (100 years ago) Post partum woman very edematous. Gave her this formula, which worked.
  • Case History Yue Mei Zhong, (modern doctor) also uses this for chronic nephritis, protein in urine.
  • This is also used for pediatric patients.
  • Huang Qi and Nuo Mi (glutinous rice) modifications:
  • Yue Mei Zhong recipe
  • Sheng Huang Qi 30,
  • Yi Yi Ren 30g,
  • Chi Xiao Dou 15g, [help with percolation]
  • Ji Nei Jin powder 9 [help digestion]
  • Nuo Mi (glutinous rice) 30g,
  • 600 ml water, first cook Huang Qi, take it out, put next two in for 30 minutes, than add last two, cook over low flame until like congee, this is one day dose.
  • Take a dry pressed kumquat (with sugar), helps to pass gas. This helps get rid of gas from large dosage of Huang Qi.
  • Dr. Huang thinks simple recipe is easier and better.
  • Case History: Hu Shi, Chinese studied in US, tried to promote Western culture in China. He disliked Chinese medicine. Then he got edema from diabetes and kidney disease and had heart problems. Went to Rockefeller Western Hospital, but didn’t help. Finally went to a famous old Chinese doctor. He was known as “Mongolian Physician” because used large dosages. [Further north, larger dosages.] He used of 300g Huang Qi. This fixed him up. People asked him, “What do you think now?” He replied that there was a need to find a scientific explanation.
  • Note: Water swelling must be in fleshy exterior of body. This is only the place Huang Qi moves water from, not for water in lungs or for ascites from hepatitis, it doesn’t work for water in chest and abdomen; don’t use for thin patients.
  • Example: Sun Yet San developed ascites from liver cancer. The question was whether to use Chinese or Western medicine. They wanted Hu to treat him. Hu gave him a very large dose of Huang Qi, but he just had a big belly, and was skinny otherwise. This just caused great distention. Hu lost his reputation over this.
  • In the Shang Han Lun, Huang Qi and Ren Shen are not used together. The reason is they go in different directions; Ren Shen is for thin patients with no fluid, lost fluids, Huang Qi for large patients with too much fluid. Ex: Bai Hu Jia Ren Shen Tang for big sweat after fever. Si Ni Jia Ren Shen Tang, for lots of sweat with no pulse, fatigue, use Gui Zhi Jia Ren Shen Tang. Bu Zhong Yi Qi Tang has small quantities of Huang Qi and Ren Shen, but here these have a different function, it is not classical. Ren Shen is good with Gan Cao, Mai Men Dong, all for thin people. It is also good with Bai Zhu.
  • C. Able to eat, but lacks strength
  • 1.Generally good appetite, able to eat large quantities of food without bloating or pain. •
  • 2. Unable to tolerate getting hungry, when hungry, will sweat, feel flustered, and feel a lack of strength
  • 3. Even after eating, feel weary and lack strength
  • 4. “Able to eat but lacks strength” is a symptom, but even more it represents constitutional state
  • Huang Qi will stabilize blood sugar, help people hold off hunger longer, and they will be able to eat less but have more energy. Fatigue may be a symptom, but may be part of the constitution. Using Huang Qi we may be treating the symptom as well as constitution.

III. Huang Qi Constitution

  • A. Tend to be overweight with soft and loose musculature, relatively damp and moist.
  • B. Complexion: dull yellow or dull red
  • C. Huang Qi Abdomen
  • 1. Abdomen is soft and loose
  • 2. Muscle atrophy and fat accumulation
  • 3. Flesh accumulates so navel sinks in
  • 4. Feels soft
  • 5. No pain
  • 6. Not tight
  • D. Good appetite and no pain or distention after meals
  • E. Some may have abdominal fullness, but more a feeling of sagging
  • F. Pitting edema in lower extremity
  • G. Skin in the area is dry and may be dark
  • H. Easily fatigued, copious sweating
  • I. Easily dizzy, short of breath
  • J. Feelings worse with exercise
  • K. Easily develop edema, especially in lower leg
  • L. Easily develop numbness in hands and feet
  • M. Easily develop infections and ulcerations

IV. Common Diseases

  • A. Cerebrovascular disease: hypertension, arteriosclerosis, coronary heart disease, angina pectoris, and basilar arterial insufficiency
  • B. Joint disease: herniated discs, cervical spine disease, bone hyperplasia, frozen shoulder, joint deformity
  • C. Metabolic disease: diabetes, obesity, elevated blood lipids
  • D. Allergic disease: allergic rhinitis, colds
  • E. Immune system disease: nephritis, anemia
  • Huang Qi is more for chronic disease, not so much for acute: there are seven prescriptions with it in the Jin Kui Yao Lüe, none in the Shang Han Lun. It has a strong connection to flesh, helps body produce more flesh. The Shennong Bencao Jing recommends it for non-healing sores. Surgeons use it to help heal cuts, help mm get force. Used for numbness and lack of strength in tissue. May be a performance-enhancing herb. For weight lifters and wrestlers, makes them stronger, Sumo wrestler is example, when water disappears, the mm are stronger.

V. Common Influencing Factors

  • A. Old age
  • B. Chronic disease
  • C. Exhaustion
  • D. Insufficient exercise
  • E. Poor nutrition
  • F. Reckless use of medicines

Huang Qi Gui Zhi Wu Wu Tang
I. Constitution

  • A. Dull yellow or red complexion, enlarged tongue that is dull purple, often middle-
  • aged or elderly
  • B. Easily fatigued, dizziness, SOB, asthma from exercise, chest oppression or pain
  • C. EKG shows lack of blood flow to heart
  • D. Generalized pain, numb limbs, lumber and leg pain
  • E. Edema in lower legs

II. Indications:

  • A. Commonly used for middle-aged and elderly patients with cerebrovascular disease and joint disease. The Shang Han Lun indicates it for painful bi, blood bi. Mostly joint pain. Was used a lot for upper class people, aristocrats, who were fatter, and who didn’t work much, and were therefore weaker, with weak mm, too much fat; when they moved they sweated easily, then exterior opened and wind would invade.
  • B. Chronic degenerative joint disease and diabetes: numbness, antonymic nervous system problems
  • C. For this formula, use in elderly, not kids. Sallow complexion, flesh hangs, Sob, pain, soft abdomen, good appetite, etc. Skin will be dry but swollen. Large dark tongue with greasy thick yellow coat. (see power point picture just before “explanation”) This not due to damp, but because the elderly eat soft food, and don’t have salvia, so the coat is not worn off. So ignore coat, look at body, dark, purplish. These kind of elderly can really eat.

III. Original formula dosages

  • Huang Qi 3 liang
  • Gui Zhi 3 liang
  • Shao Yao 3 liang
  • Sheng Jiang 6 liang
  • Hong Zao 12 pieces
  • Cook from 6 cups down to 2, take three times per day
  • A. Explanation
  • 1. Gui Zhi and Bai Shao is a famous combination to regulate ying and wei. To Dr. Huang, this means regulating the circulation: Gui Zhi dilates arteries, Bai Shao dilates the veins, so circulation is increased. These two work systemically, esp. when combined with Huang Qi.
  • 2. Sheng Jiang: Don’t underestimate the importance of Sheng Jiang. Here in the originally formula used 6 liang, double of others. It promotes peripheral circulation, warms the body, can induce sweating, dispels wind and cold, and can unblock blood impediment. Patients should keep warm after taking it and can use Sheng Jiang in food regularly. Must not wear shorts, lower legs must be covered. Careful, can’t use too much or bloating. (If bloating, the first consideration is are they Huang Qi type?) But if correct, they will bloat but will feel good. You can add lemon, Chen Pi, citrus eaten during day. Use preserved orange peel to keep digestion going.

IV. Dr. Huang’s dosage

  • Huang Qi 30
  • Gui Zhi 15
  • Chi Shao 15
  • Sheng Jiang 15
  • Hong Zao 20g
  • Water decoction: For acute must use full dosage, but for chronic, or for long-term use, one can use less. This tastes good and so patient compliance is high. One can use less for cheap patients or with granules.
  • A. Modifications:
  • 1. Dr. Huang adds Ge Gen up to 30g [equal to Huang Qi] and Chuan Xiong 15 [up to Gui Zhi dose]. Ge Gen raises yang, why use it for hypertension? Ge Gen raising the clear qi, not evil qi. When the clear doesn’t rise one has dizziness etc., due to insufficient circulation to head. These increase blood supply to brain. Also these people have tight nape of neck and further back, an indication for Ge Gen. When blood pressure decreases this feels better. Need to use large dosages to lower blood pressure. Chuan Xiong for HA.
  • 2. Add Ge Gen and Chuan Xiong for cervical spine disease, from head to lower back spine use Niu Xi,.
  • 3. Add Chi Shao, Huai Niu Xi, Dan Shen, Shi Hu for lower leg numbness from diabetes
  • 4. Add Shao Yao Gan Cao Tang and Ma Huang Fu Zi Xi Xin Tang for sciatic pain, severe lower leg pain, and difficulty walking.
  • 5. For distention, citrus eaten during day. Use preserved orange peel to keep digestion going.

V. Classical formula pattern

  • A. In Blood Impediment, yin and yang are both faint, cun and guan are both faint, while the chi is a little tight, the exterior symptoms show numbness on the skin, just as Wind Obstruction, and Huang Qi Gui Zhi Wu Wu Tang governs.
  • B. Explanation:
  • 1. Blood impediment: ancient disease name,
  • 2. Symptoms: inflexible joints, muscle aches
  • 3. Occurs often in patients who are well fed, who lack physical exercise, are fleshy, lack physical strength, fatigued easily, sweat easily
  • C. Common Diseases
  • 1. Hypertension
  • 2. Atherosclerosis
  • 3. Basilar artery insufficiency
  • 4. Strokes
  • 5. Head aches, fatigue, dizziness.
  • Case History: End stage hypertension
  • Shen, 62, BP: 180/100 even though he takes lots of pharmaceuticals (12-15 pills per day.) Swollen leg, soft belly, good appetite. Big nose, big lips. Hematuria (+++). Renal disease and leg pain from diabetes, lower leg edema. Dizzy, very tired, low back sore, dry mouth, swollen tongue with slimy fur in center.
  • Huang Qi 60 (minimum 30g some use 120)
  • Rou Gui 6g (add last)
  • Gui Zhi 10
  • Chi Shao and Bai Shao15g
  • Huai Niu Xi 30
  • Shi Hu 30
  • Dan Shen 12g
  • Ge Gen 30
  • Gan Jiang 6
  • Hong Zao 20g
  • After two months BP stable at 140/80. No fatigue, legs had strength, no LBP, etc.
  • Case History Multiple problems
  • 63 year old man 2004 March
  • 1.Pituitary tumor 2.Severe sleep apnea 3.Mesangial proliferative glomerulonephritis
  • 4.Diabetes 5.Hypertension. Hematuria(+++) As of 2005 November: 180/100mmHg
  • BP. Medication for HTN ineffective.
  • Symptoms: Dizziness, as if drunk or feverish, fatigue, low back soreness, dry mouth,
  • soft loose abdomen, strong appetite, enlarged tender tongue with slimy fur in center
  • Formula:
  • Huang Qi 60g
  • Rou Gui 6g (add last)
  • Gui Zhi 10g
  • Chi Bai Shao each 15g
  • Huai Niu Xi 30g
  • Shi Hu 30g
  • Dan Shen 12g
  • Ge Gen 30g
  • Gan Jiang 6g
  • Hong Zao 20g.
  • After more than two months, BP stable at140/80 mmHg. No fatigue, lower legs have strength, no low back soreness, good complexion.

VI. Cardiac diseases

  • Angina pectoris: This is chest bi, easily sweat with activity, swollen legs. One can at least reduce symptom severity and frequency. Add Ge Gen Chuan Xiong Dan Shen, Shi Hu and Huai Niu Xi. For cardiac diseases, one must add Rou Gui in a large dose. Usually more than 20 g . One can use Rou Gui and Gui Zhi together. For these cases substitute Chi Shao for Bai Shao.
  • Case History: Cardiac disease
  • Mr. Wang, govt. official, 58, Nov 2004. Very stressful life, smoke and drink a lot. Had heart attack, did bypass. After surgery, fat, can’t walk, tired, SOB, palpitations. Chief complaint: palpitations and chest oppression for ten years, exercise-induced asthma for 3 years. On oxygen. In 2002 coronary artery bypass surgery; 2004 polymyositis. Frequent weakness in extremities, minimal activity brings on palpitations and SOB. Only able to walk for short stretches. On oxygen for 5 hours a day. Tranquilizers and oxygen before bed. Life activities very limited.
  • Formula:
  • Huang Qi 80
  • Gui Zhi 20
  • Rou Gui 10 (put in at end)
  • Chi Shao 40
  • Bai Shao 20
  • Dan Shen 20
  • Dan Pi 12 for psoriasis
  • Tao Ren 20
  • Huai Niu Xi 60
  • Zi Cao 20
  • Sheng Jiang 4 pc
  • Hong Zao 20
  • Water decoction, take twice a day. Advised to increase exercise as possible.
  • Wang continued on basic formula until 2005 (over 300 packs). Increased physical activity significantly and exercising every day, strength in the extremities, no shortness of breath or palpitations, no breathing difficulty, spirit significantly improved. He lost 18 pounds. However, even though he had quit smoking when he had his operation and led a less prodigal life, last year he died of lung cancer.
  • Case History: Spontaneous sweating in cardiac disease
  • Mr. Jiang, 80,2008 February. Many years of hypertension and heart disease, sweats easily with even minimal activity, copious sweat, after sweating feels cold, cough. Hospitalized for heart disease- improved, but sweating persisted. Relatively strong body, moist skin, asthmatic, lower leg edema, enlarged tongue, pale tongue, floating large pulse
  • Formula:
  • Huang qi 60g
  • Gui Zhi 15g
  • Rou Gui 10g
  • Chi Shao 15g
  • Gan Jiang 10g
  • Hong Zao 30pc
  • 5 packs.
  • After one week, patient said: “Sweating very much better, easier to climb stairs”
  • Dr. Huang increased Huang Qi to 100g, no other changes. After 10 more packs, there was continued improvement.

VII. Musculoskeletal diseases

  • A. Lumbar disc herniation, cervical spine disease, bone hyperplasia,
  • frozen shoulder
  • B. Body pain, weakness, stiffness, difficulty with movement, muscular atrophy
  • C. Modifications: Add Huai Niu Xi, Ge Gen, Bai Zhu
  • Case History: Lumbar spinal stenosis
  • 39 year-old woman: 3 years of numbness and pain in lower extremities, lumbar pain for six months, when fatigued feels as though walking on cotton, knee pain, lameness, low back pain worse with weather changes, dull pale-red tongue, thin moist fur, soggy pulse, spinal stenosis and disc protrusion (L4-5)
  • Formula:
  • Huang Qi 30g
  • Gui Zhi 12g
  • Bai Shao 12g
  • Da Zao 15g
  • Sheng Jiang 40g
  • Bai Zhu 12g
  • Gan Cao 10g
  • Fu Ling 30g
  • 5 packs.
  • After two packs, feeling of heat in back, feeling of qi moving down to feet,
  • subjective symptoms improved. After 5 more packs, even though weather changes, low back not painful, only slight numbness in legs but no pain, knees achy with fatigue but not painful, feeling of walking on cotton very reduced. Continued for 5 more packs

VIII. Other diseases
A. Vascular obliterans. arteritis; peripheral vascular disease: For these add Si Miao Yong An Tang: Dang Gui, Xuan Shen, Jin Yin Hua, Gan Cao.
B. Chronic kidney disease, uremia [because of edema] For people who must use dialysis, or may be able to delay dialysis. Huang Qi Gui Zhi, Bai Shao, have a diuretic effect, but also increase circulation to kidneys, help kidney function.
C. Post-stroke: Can combine with Bu Yang Huan Wu Tang.
D. Diabetic peripheral neuropathy: Numbness of the limbs, decrease in sensation. One can combine this with Si Wei Jian Bu Tang: Huai Niu Xi, Chi Shao, Shi Hu, Dan Shen.
E. Varicose veins: Combine with Gui Zhi Fu Ling Wan.
F. Diabetes: Most patients have a good appetite but are weak, with peripheral neuropathy, sores, hypertension, renal failure, heart problems. This is probably for type 2 diabetes.
Add Ge Gen, Chuan Xiong that reduce blood plasma glucose level. This has cerebral protective effects, heart protection, kidney protection. Makes body work better, lowers hunger.
G. Post-partum disease: spontaneous sweating or night sweating, generalized pain, numbness in the hands, atrophy in the legs
H. High fever or colds in the elderly
Case History: High fever of unknown origin
90 year-old man with diabetes, Parkinson’s, atrial fibrillation, and BPH, but mentally clear and physically fit. Previous spring, high fever with cold shivers, had septicemia, after using antibiotics the fever lowered, but then spiked again, he tried this several times with the same results. Happened once a month. Hospitalized and on various meds but no resolution. Current exam: hand trembling, legs unsteady, swollen legs, thick dry tongue fur, dull pale tongue, lower extremity edema, moderate pulse with occasional irregularity
Formula:
Huang Qi 60g.
Gui Zhi 10g.
Rou Gui10g.
Chi Shao 10g.
Bai Shao 10g.
Gegen 60g
Gan Jiang 10g.
Hong Zao 20g.
Water decoction, one bag for 2-3days.Take for 3 months.
From the time began herbs, temperature was normal. After 3months, no more fevers. Had ringworm of the nails that also resolved.

Fang Ji Huang Qi Tang
I. Indications

  • A. Traditionally used for lower extremity edema with soft, loose flesh and lack of strength

II. Original formula dosages

  • Han Fang Ji 4 liang
  • Gan Cao 2 liang
  • Huang Qi 5 liang
  • Sheng Jiang 3 liang
  • Bai Zhu 3 liang
  • Strongest for promoting urination, effective for pain. For a Huang Qi constitution, urination will increase to varying degrees. Dosage of Huang Qi and Fang Ji (30-60g each per day) must be large, Gan Cao very small, but this is original rx, don’t take Gan Cao out completely. Fang Ji important for joint pain in lower extremities, arthritis and gout, promotes urination, important for edema. Use large quantities.
  • Bai Zhu also promotes urination, expels water from whole body including interior.

III. Classical formula pattern

  • A. Original wind water
  • 1. Edema from waist down, heavy feeling in body.
  • 2. Copious sweating, aversion to wind, floating pulse.
  • 3. Joint pain, low back, knees, ankles, difficulty walking.
  • 4. This is wind water: the floating pulse indicates the exterior. The person may sweat from the head. No other exterior disease. The disease includes heaviness in the lower body. From the lumbar up, all is well. From the lumbar down is edematous and inflexible.
  • B. Important symptoms
  • 1. edema that is more distinct from the lumbus down and heavy body
  • 2. sweating and aversion to wind
  • 3: joint pain, especially knees and ankles, may also be heaviness in the joints, inhibited movement, and inflexibility

IV. Dr Huang’s dosages

  • Han Fang Ji 15g
  • Gan Cao 3g
  • Huang Qi 30g
  • Sheng Jiang 10 pc or Gan Jiang 10g
  • Bai Zhu 15g
  • Hong Zao 20g

V. Diseases

  • A. Idiopathic edema, common in women, may combine with Wu Ling San, very effective. Hormone function of client is OK. Get lots of urine. May need to add Yue Bi Tang from Jin Kui Yao Lüe. Ma Huang with Huang Qi potentiate each other.
  • B. Musculoskeletal problems: arthritis of joint with deformity, rheumatoid and rheumatic arthritis, gouty arthritis, lower edema often present. If there is pitting edema, will probably work.
  • C. Lumbar disc herniation: can use with Huang Qi Gui Zhi Wu Wu Tang plus Huai Niu Xi
  • D. Gout: add Wu Ling San, this helps excrete uric acid, basic for gout.
  • E. Hypertension In cases with dull yellow complexion, edema in the lower limb, add Ge Gen, Huai Niu Xi, and Ze Xie . Use a very low dosage of Gan Cao if at all. If using Gan Cao one must add Ze Xie to counteract it.
  • F. Various diseases described in case histories below: intractable knee pain, lower body sweating, obesity, diabetes, diabetic ulcerations on lower extremities, body odor, and excessive sweating.
  • Case History: Intractable knee pain
  • Ms. Zhao, 54; multiple year history of bilateral knee pain that did not respond to acupuncture, tui na, herbs, Western meds, and Chinese herbs. Lower leg edema and knee tissue felt soggy, lack of strength, sweating, overweight, pale complexion, loose stool,
  • some redness in the legs. This was a very difficult case, there wasn’t much hope. She was Huang Qi constitutional type, overweight, sweat easily, etc.
  • Formula:
  • Fang Ji 10
  • Huang Qi 30
  • Bai Zhu 25
  • Gan Cao 3,
  • Sheng Jiang 2
  • Da Zao 10
  • Niu Xi 30
  • Dan Shen 15
  • Shi Hu 12
  • Chi Shao 15
  • Ze Lan 10
  • Ze Xie 10
  • Di Long 6
  • 7 packs.
  • Commentary: This was a case of a student of Dr. Huang. The first formula is the classical one, the next 4 additions are those of Dr. Huang’s for the legs, the last additions are those of the student. 2nd visit: edema and pain both reduced. He added Mu Li and Lu Xian Cao. After 14 packs all symptoms reduced, including sweating.
  • Case History: Sweating
  • 33 year-old man had surgery for tibial fracture and ligament tear. After had abnormal sweating from the same leg and pain. Patient well-built, skin of left leg was darker and sweat was copious, so pants and socks were wet. Dull red tongue with thick slimy yellow fur. Pulse small, soft, and slightly rapid. They tried Si Miao San plus Qin Jiao, Wei Ling Xian, and Wei Mao. This helped with pain, but sweating was mostly the same. The sweat was copious, but not foul-smelling, tongue fur had become thin.
  • They changed the formula to: Fang Ji Huang Qi Tang
  • Fang Ji 10
  • Huang Qi 12
  • Cang Zhu 10,
  • Zhi Gan Cao 5
  • Sheng Jiang 4 pc
  • Hong Zao 3 pc.
  • After 3 packs, sweating reduced. Added Wei Ling Xian 15 for 4 more packs.
  • Case History: Obesity
  • Ms. Wang, 46, last year after her period came found she had gained 8 kg. Symptoms included shortness of breath, copious sweating that was worse with exercise, heaviness of the limbs, lack of mental clarity, poor appetite, hypersomnia, loose stools, easily caught cold. Pale enlarged tongue with tooth marks and a white slimy fur. Slippery pulse.
  • Formula:
  • Fang Ji 60
  • Huang Qi 60
  • Bai Zhu 30
  • Cang Zhu 15
  • Fu Ling 15
  • Ze Xie 15
  • Jiao Shan Zha 20
  • Yin Chen Hao 20
  • Gan Cao 6,
  • Chen Pi 10
  • The patient was extremely obese so needed very large dosages. Upper body sort of OK, but middle body big and legs swollen with pitting edema. Can add Wu Ling San.
  • Case History: Diabetes
  • (This has not been translated, see the power point) Report from Japan, 11 cases of overweight diabetic patients. Used granules for six months, blood sugar, cholesterol, glyiscerides improved with significant weight loss.
  • Case History: Diabetic ulcerations on lower extremities
  • (See power point and picture) Report from Japan Edo period. Ulcers can go to bone, clear pus coming out, loose flesh, but with edema. We see this today. Need large dosage of Huang Qi to reduce swelling and generate new flesh. Dr. Huang would use this and his 4 herb addition.
  • Case History: Body Odor
  • Formula:
  • Fang Ji 30
  • Huang Qi 30
  • Bai Zhu 15
  • Gan Cao 6
  • Sheng Jiang 9
  • Da Zao 20
  • Used to treat 12 cases of body odor, all cured in 2-6 months. Report of 15-year case of body odor, patient obese, soft loose flesh, underarm sweating copious, fatigue.
  • After 2nd day on this formula, large amount of urine and sweating reduced. Symptoms gradually abated.
  • Case History: Excessive sweating
  • 24 year-old woman with excessive armpit sweating that stained her clothing yellow and was foul-smelling. Worse around period and in summer. Reduced taste, poor appetite, fatigue, loose stool, late period with pale blood, obese, liked to eat rich foods, pale tongue with turbid white fur, floating slippery pulse.
  • Formula:
  • Fang Ji 30
  • Huang Qi 30
  • Bai Zhu 15
  • Cang Zhu15
  • Fu Ling Pi 20
  • Ze Xie 20
  • Che Qian Zi 12
  • Che Qian Cao 12
  • Gan Cao 6
  • After more than 20 packs, was cured. Used Fang Ji and Huang Qi up to 60g. This can be used for underarm sweating, especially in summer. Effective because reduces sweat? Odor itself hard to deal with, but reducing sweating helps the situation.

VI. Constitution

  • A. Copious sweating, easily sweating, sweat is yellow and/or foul-smelling
  • B. Edema, especially in the lower extremity, often accompanied with knee pain
  • C. Large, soft abdomen, buttocks and legs soft and saggy
  • D. Common in middle-aged and elderly women

VII: Explanation

  • A. The formula promotes urination. Huang Qi constitution: person is like a bag of water. After using this formula, urination will increase to varying degrees.
  • B. Dosage of Huang Qi and Fang Ji must be large (60 g or more), but Gan Cao should be small ( 3-6 g).

Yu Ping Feng San
I. Indications

  • A. Traditionally used to consolidate the exterior and stop sweating
  • B. Used for fatigue, spontaneous sweating, aversion to wind

II. Original formula dosages

  • Fang Feng 1 liang
  • Huang Qi 1 liang
  • Bai Zhu 2 liang

III. Dr. Huang’s dosages

  • Huang Qi 15g
  • Bai Zhu 20
  • Fang Feng 15
  • Cook in 1000ml of water for 40 minutes to get 2300 ml. Divide and take 2-3 doses. Can also be used as a powder

IV. Constitution

  • A. Layered over normal Huang Qi type: sweat easily, aversion to wind, easily, allergic, nasal congestion, cough or asthma, colds, easily becomes itchy, i.e. more respiratory problems than previous rx.
  • B. Easily has diarrhea or stool that is not fully formed
  • C. Easily develops edema, especially in the lower leg

V. Suitable Diseases

  • A. Copious sweating following chemotherapy or radiation for cancer: use with Zhen Wu Tang and Huang Qi Gui Zhi Wu Wu Tang for low-grade fever and copious sweating following chemo for myeloma
  • B. Post-surgical abnormal sweating :with Huang Qi Gui Zhi Wu Wu Tang for
  • sweating or slow wound healing after appendectomy.
  • Case History: Myeloma
  • Dr. Huang’s patient had many myelomas, very difficult therapy. She was very afraid of cold, sweating, fever. She said was done with chemo, not afraid to die, used Yu Ping Feng San with 60g of Huang Qi, plus Zhen Wu Tang and Gui Zhi. [and Huang Qi Gui Zhi Wu Wu Tang?.] After a week much better. Continued to treat her, she also had proteinuria from chemo damage, gave her that congee formula. She recovered.
  • Case history: Post surgical abnormal sweating.
  • Abdominal surgery, wound not healing, lots of sweating, added Huang Qi Gui Zhi Wu Wu Tang to get wound to close.

VI. Other Diseases

  • A. Pediatric diabetes: may add Gou Qi Zi to keep insulin stable
  • B. Recurrent respiratory infections in children or the elderly: can be considered like Chinese medicine gamma globulin
  • C. Pediatric allergic rhinitis
  • D. Chronic kidney disease: Use with Zhen Wu Tang and Huang Qi Gui Zhi Wu Wu Tang for proteinuria from chronic nephritis
  • E. Also for diabetic kidney disease and copious sweating in diabetics
  • Case History: Fissures in the skin of the hands and feet
  • Elderly farmer with cracked skin on hands and feet for months that were itchy and painful, severely affecting life quality. He was yellow and swollen.
  • Formula: Yu Ping Feng San plus Huang Qi Gui Zhi Wu Wu Tang with Huang Qi @ 60g
  • After 2 packs, no more itching or pain. After one week, fissures had healed. After 2 weeks, skin was healthy looking.

VII. Explanation

  • A. Small dosage, long duration.
  • B. According to Yue Mei Zhong: treated a patient for exterior deficiency with spontaneous sweating using large dose in decoction. After 3-5 packs, symptoms stopped. Then recurred and same formula again produced effect. Then recurred
  • again. Seemed like formula could not produce lasting effect. Saw Pu Fu Zhou
  • treat a similar pattern with powdered formula, 9 g per day, taken for 1 month.
  • Sweating stopped and did not recur.

VIII. Yu Ping Feng San vs. Huang Qi Gui Zhi Wu Wu Tang

  • A. Both formulas treat spontaneous sweating
  • B. Yu Ping Feng San: immune system irregularity, diarrhea, yellow complexion, edema, respiratory and kidney diseases common, more common for pediatrics
  • C. Huang Qi Gui Zhi Wu Wu Tang: irregularity in neurovascular system, muscle pain, dizziness,
  • palpitations, dull purple tongue, vascular and joint diseases common, more common for elderly

IX. Yu Ping Feng San vs. Fang Ji Huang Qi Tang

  • A. Both treat copious sweating and edema
  • B. Yu Ping Feng San: fear of wind, nasal congestion: problems related to respiratory system: wind in the upper
  • C. Fang Ji Huang Qi Tang: lower extremity joint pain: damp in the lower

X. Fang Feng

  • A. Fang Feng is very useful:
  • 1. Joint pain with Bai Shao , Gan Cao, Qiang Huo, for joint pain, both arthritis.
  • 2. Itching, anti-allergic, with Chai Hu and Jing Jie and Bo He to work like this. Pollen allergies, itchy.
  • 3. Immune system disorders with Huang Qi, Bai Zhu and can add Chai Hu. Xiao Chai Hu Tang, Shan Yao Gan Cao tang + Fang Feng is especially good for liver disease. Sjogrens, autoimmune disease, since Fang Feng acts on the immune system.
  • 4. Abdominal pain, Tong Xie Yao Fang, with Bai Shao, Chai Hu , Gan Cao.

Eric Brand on Raw vs Processed Huang Qi:

Huang Qi was initially processed by simply discarding the “neck” of the root, a practice that dates back to the Jin Gui Yao Lue (“Essential Prescriptions from the Golden Cabinet”). Steaming was added a few centuries later in the Lei Gong Pao Zhi Lun (“Master Lei’s Treatise on Drug Processing”). Honey-processing for Huang Qi developed in the Song dynasty (960-1280 CE). Other adjuvants for Huang Qi processing came later, such as wine, ginger juice, rice water, and even human breast milk. Today, the two most popular forms of Huang Qi on the market are the crude form and the honey processed form.

Honey-processed Huang Qi is made by mixing purified honey with water (in Chinese medicine, honey is often boiled before use to make “purified honey,” known as Lian Mi). The water-honey mix is used to briefly soak the Huang Qi, and then the Huang Qi is dry-fried until it becomes deep yellow and is no longer sticky. A toaster oven is often used in the modern day; the honeyed astragalus is simply baked at a low temperature until it becomes deep yellow and dry.

Unprocessed Huang Qi, called Sheng Huang Qi or simply Huang Qi, is the best form for boosting the defense qi to secure the exterior. It is also preferred for drawing toxin and engendering flesh. Finally, unprocessed Huang Qi is best for disinhibiting urination to reduce swelling. It is generally used for spontaneous sweating or the tendency to catch common colds easily due to insecurity of the exterior with weak defense qi (wei qi). It is also indicated for qi vacuity patterns of water swelling and for flat- and welling-abcesses that fail to rupture or rupture and fail to close. Exemplary formulas include Yu Ping Feng San (Jade Wind-Barrier Powder), Fang Ji Huang Qi Tang (Fangji and Astragalus Decoction), and Tou Nong San (Pus-Outthrusting Powder).

Honey-processed Huang Qi, called Zhi Huang Qi, Mi Huang Qi or Huang Qi (Mi), tends to be moistening and is best for boosting qi and supplementing the middle burner. It is used for spleen-lung qi vacuity with reduced food intake, sloppy stool, shortness of breath, and lack of strength. It is also indicated for center qi fall manifesting in enduring diarrhea, rectal prolapse or uterine prolapse. For bleeding due to spleen qi failing to contain the blood, the honey-processed form is also preferred. Exemplary  formulas include Gui Pi Tang (Spleen-Returning Decoction) and Bu Zhong Yi Qi Tang (Center-Supplementing Qi-Boosting Decoction).

Jiao Shu-De sums up the differences succinctly in his Ten Lectures on Medicinals text: “used raw, Huang Qi moves in the exterior…used mix-fried its emphasis is on the interior.” Despite these stated differences and the emphasis from pao zhi texts, there are a few discrepancies around. For example, multiple pao zhi texts state that the action desired for the formula Yu Ping Feng San is best accomplished with the crude product, but the original source text for the formula specified honey-processed Huang Qi.

Link to Thorne Monograph

 

Dose: 9-60g

Ren Shen – Ginseng root – Panax ginseng – “Man Root”

Nature: sweet, slightly bitter, slightly warm

Enters: Spleen, Lung   (some say also Kidney and Heart)

Actions: Powerfully tonifies the source Qi; tonifies Lung Qi; tonifies spleen and stomach Qi; generates body fluids, eases thirst; benefits heart Qi; calms the Shen; slightly nourishes Yin; improves wisdom; the red form (steamed) tonifies Yang.

Indications:
• Qi collapse (as after severe vomiting, diarrhea, bleeding): cold sweats, shallow breathing, shortness of breath, cold limbs, weak and feeble pulse.
Ren shen can be used alone after severe blood loss.
• Spleen Qi deficiency: fatigue, poor appetite, distended epigastrium, chest, or abdomen, vomiting, chronic diarrhea, prolapse of stomach, uterus, or rectum.
• Lung Qi deficiency: shortness of breath, spontaneous sweating, weak pulse, labored breathing, wheezing (usually also a concurrent failure of the kidneys to grasp the Qi).
• Body fluid injury: thirst, wasting and thirsting disorder, injury of body fluids by high fever and profuse sweats.
• Heart Qi/blood deficiency: palpitations, anxiety, insomnia, forgetfulness, restlessness, lots of dreams.
• Adaptogenic: long-term use makes one better able to deal with stressors (temperature changes, fatigue, infection, etc.).
• Has both stimulatory and sedative effects on the CNS.
• Accelerates transmission of nerve impulses, shortens latency period of nerve reflexes.
• Can improve myocardial utilization of nutrients and cardiac function.
• Increases synthesis of proteins and nucleic acids.
• Diabetes: may lower blood sugar and glucosuria, seems to act synergistically with insulin.
• Cultivated forms of ginseng are called Yuan shen.
• Ginseng cured in rock candy, Bai shen/Tang shen is used for Qi and Yin deficiency patterns, especially for the spleen/stomach.
• The small inexpensive rootlets are called Shen xu.
• Fresh-dried ginseng, Sheng shai shen can nourish Yin, and is similar to Xi yang shen (American Ginseng).
• When cured by steam, ginseng turns red – Hong shen – and is warmer, for Qi and Yang deficiency (can rescue devastated Yang).
• Most Korean ginseng is stronger than Chinese and is usually the red form.
• The white form is generally cooler than red.
• Quality is difficult to determine. One measure is that tap root and all lateral rootlets are intact and unbroken, though others dispute the significance of this factor. Another measure is the straightness of the root (where straighter is better). Size and age are the most general indicators of potency. Wild is considered better than cultivated.
• Because of its expense, the herb is often decocted separately in small amounts of water in a double boiler.
• The antidote for ginseng overdose (with symptoms such as headache, insomnia, palpitations, and a rise in blood pressure) is mung bean soup.
Jin: Use 30-50g alone (especially the red form) to stop bleeding from (spleen) deficiency.
PFGC: Can be used for fevers: where the patient’s righteous Qi is constitutionally weak and pathogens are trapped inside.
• Can be used for any deficiency – even with heat or bleeding.
• With Sheng ma, it can drain Lung fire.
• With Fu ling, it can drain kidney fire.
• With Mai men dong, it can boost the pulse.
• With Huang qi and Gan cao, it can lower fever.
• Useful for deficiency pain.
• The imperial herb for slight Yin deficiency with severe Yang deficiency leading to steaming sensations due to the Yin not being able to contain the vital fire.
• Can nourish Yin and produce blood.
• (In the proper context:) it boosts earth to generate metal, brightens the eyes, opens the heart, invigorates mental clarity, nourishes the Jing, supplements the Shen, controls palpitations, resolves thirst, dispels restlessness, opens the channels, boosts the pulse, breaks up accumulations, eliminates phlegm, cures all conditions involving Qi deficiency and blood injury.
• Not for Yin deficiency fire causing asthma and coughing.
HF: Patients with Gu Zheng (Gu parasites) tend to react negatively to Ren shen.
Hsu: Acts synergistically with insulin to lower blood sugar; antidiuretic; lowers blood cholesterol; increases protein synthesis; stimulates sex hormones; cardiotonic.
CHA: (Al Stone, 9-26-2000)
I. Yuan Shen (“Garden Ginseng,” meaning cultivated ginseng)
A. Hong Shen (“Red Root”) Its color is brown and red. It is slightly transparent. After cleaning, it is steamed two to three hours, then oven dried or sun dried. This is the most common variety of Yuan shen. Its smell is very pleasant, with a slight bitter taste.
B. Bian Tao Shen (“Edge Long Root”) Similar to red ginseng in color and quality. It is longer that red ginseng with a greater diameter. Its branch, too is longer and wider. This suggests a better quality medicine than red ginseng. C. Tang Shen (“Sugar Root”) First the Yuan shen is placed into boiling water for 3 to 7 minutes, then placed into cold water right away to soak for about 10 minutes, then sun dried. Liu huang (sulfur) is burnt beneath the ginseng to smoke it. The essence of the Liu huang passes into the ginseng via the smoke. This may be a preservative for the ginseng to keep it free of worms. They use a special needle to puncture tiny holes in the root. Then they place the ginseng into highly concentrated sugar water for more than 24 hours. Then the ginseng is placed under direct sunlight to dry it out. Then they beat the ginseng with a wet towel to soften, and repeat the process from the punching of the holes. Once it has been in the sugar water again for 24 hours it is rinsed off and sun- or oven-dried. The color becomes a lighter yellow/white. The smell is pleasant. The taste is sweet and slightly bitter.
D. Bai Ren Shen (“White Man Root”) Quality and shape is a kind of like sugar shen. Most of the time it has a good shape (straight) and is very white. It is longer than red ginseng. The ginseng’s beard (the long hairy roots at the end of the branches) is short, but very brittle.
E. Sheng Shai Shen (“Raw Sun-dried Root”) This kind of ginseng is washed until clean and then partially dried by placing in the sun for one day (one full day of very clear, brilliant sunshine). The next day, it is smoked with Liu huang, possibly as a preservative. Then the sun-drying process is continued until completely dried. The color is mostly yellow, a little brown. It is crisp and lighter now. The smell is pleasant. The taste is bitter.
F. Bai Gan Shen (“White Dry Root”) The superficial skin of the root is scratched off. The color is light yellow or white. It is called “white” because it has been made lighter by the scraping of the skin. Quality and shape are similar to Sheng shai shen. G. Qia Pi Shen (“Strangled Skin Root”) The method of preparation is similar to Tang shen: Put ginseng into boiling water for 3 min, then remove until cold, then replace into the boiling water. Repeat until the it has been bathed three times. At this point, root will be 30% done. Then, put the it into boiling water for 20 minutes. Remove it, let it cool, and punch tiny holes in it as with Tang shen. Then place it into slightly sweetened sugar water (nowhere near as concentrated as for Tang shen). Then remove and oven dry. This will cause the skin to separate from the meat. Then use a bamboo knife to make small indentations into the root, very superficial. The smell if pleasant. The taste is slightly sweet and slightly bitter as typical ginseng.
H. Da Li Shen (“Great Force Root”) Take fresh raw ginseng for several seconds and remove. [sic] Then dry very well beneath the sun (as many days as necessary until fully dry). This is the most natural form of ginseng. This kind of ginseng is not often exported because it has a short shelf life. It is the strongest and least prepared. It has a slightly yellow color and is slightly transparent. The beard and branches are cut off to leave only the best part of the ginseng, however the head is left on for consumers to better assess the quality of the herb. This root is hard and crisp. Smell is pleasant, taste is bitter.
II. Ye Shan Shen (“Wild Mountain Grown Root”)
The shape looks like garden ginseng. The body of the root is wider and shorter. Usually there are two major branches to the body, which makes the root look like a body with two legs. In the head you will find numerous concentric wrinkles. The legs tend to be curved, not straight like garden ginseng. The root beard (small rootlets) is much longer than that of garden ginseng – one or two times the length of the “legs” of the root. The beardy roots also have pearly spots on them. This is the biggest difference between wild and cultivated ginseng – them pearly whites. Wild ginseng’s color (of the whole body) is a light yellow. The skin of the root is very soft. Its natural smell (before cooking) is stronger than garden ginseng. It is sweet, with a light bitter quality also. The preparation procedures are different. There are three methods of preparation (see above for details): 1. Sheng shai shen 2. Tang shen 3. Qia pi shen
Wild Ginseng of the best quality is very large and juicy, full of liquid. Wrinkles that are small and compact are better than wide and thick wrinkles. Longer head is better than a short one. The more pearls on the beard roots the better.
III. Korean Ginseng [Gao Li Shen or Chao Xian Shen]: Korean ginseng, of course, grows in Korea. It, too, comes in both wild and garden varieties. The more northern, the better, though it is grown in the South as well.
Bei Zhi Shen (“Fork in the Road Straight Root”). Probably named because the herb is a little bigger and the legs resemble a “Y” in the road. These roots have a stronger tonification function.
Production: There is Korean red ginseng and Korean white ginseng. Red is better, stronger than white. Preparation is the same as Chinese ginseng.
SD: Ginseng (Panax ginseng) has been a prominent herb in Chinese medicine for at least twenty centuries. Due to scarcity of the herb at various times, its use has been restricted and substitute herbs have replaced it in certain prescriptions. For example, in China, most prescriptions that would otherwise contain ginseng are made with the less-expensive herb codonopsis.
Classically, ginseng is used to restore vital energy (qi) and to generate fluids (especially for the stomach). A major use was for the recovery from debilitating feverish diseases which parched the body fluids and drained energy. It was also relied upon as a sedative and longevity tonic. Through extensive experience with its use, the number of indications for it increased. The diversity of ginseng actions that were claimed was the basis for its original description as a panacea by Western visitors to China centuries ago. The official genus name, Panax, comes from the word panacea. When Western-style research was initiated in the Orient on a large scale following World War II, ginseng became the primary subject. Its chemical constituents were analyzed, and numerous physiologic actions were determined. These include reduction of stress reaction, normalization of blood pressure and blood sugar levels, increase in endurance, improved mental functions, resistance to disease (and to chemicals and radiation), longer life span, and anti-tumor activities.
Much of the ginseng research during the past few years has done little more than reconfirm previous findings about ginseng’s ability to normalize body functions. These general findings are displayed in Appendix 1. Different
dosages, methods of preparation, and testing situations are tried out in some of the recent studies. Sometimes the results appear contradictory, but as the information accumulates, many of the results can be reasonably explained. The current thrust of research is in three areas: immune system actions, cardiovascular effects, and hormonal effects.
IMMUNE SYSTEM STUDIES
At the Institute of Traditional Chinese Medicine in Jilin Province (where ginseng is grown), researchers in the pharmacology department evaluated the effects of ginseng on immune responses. The immune responses of mice were tested with different dosages of ginseng extracts obtained either from the leaf or the root of ginseng. Significant changes in the response of the reticuloendothelial (RES) system were found,especially with moderate doses of the root extracts. Larger doses did not improve the response. RES cells are the immune system components that devour foreign organisms without leaving their original sites in the liver, spleen, and other tissues of the body. When tumors were implanted in mice, the response of the immune system was notably improved by the ginseng extracts and this caused a reduction of tumor weight by 1/3 to ½. Levels of antibodies in the blood were also significantly increased when the mice, injected with foreign blood cells, had received ginseng pre-treatment. In these experiments, ginseng was administered daily for five to ten days prior to testing the immune system responses. In human patients undergoing cancer therapies with radiation or chemical agents, it was shown that the anti-cancer effects of these therapies were increased. Ginseng administration accelerated recovery of the immune system and the function of the bone marrow (producing red blood cells) in these patients. As a result of these investigations, ginseng extracts are now used to treat patients with chronic hepatitis (who often suffer further depression of immunity due to steroid treatment) and those who have undergone cancer therapies.
A distant relative of ginseng, eleuthero ginseng (Eleutherococcus senticosus), is used in Chinese hospitals to treat cancer patients undergoing chemotherapy. It protects the immune system and is used in the Soviet Union as a preventive for colds and flu.
THE HORMONAL SYSTEM
It was established by modern research in the 1970’s that ginseng relieves stress on the adrenal glands. It has recently been proven that both ginseng and deer antler, a Chinese health tonic often combined with ginseng, affect luteinizing hormone (LH). In laboratory experiments at the Department of Physiology at Jianxi Medical College, animals were given ginsenosides from ginseng and the active fraction from deer antler. Luteinizing hormone secretion increased dramatically, about ten fold. This hormone influences the menstrual cycle in women and it stimulates testosterone secretion in men. Ginseng and antler extracts were also shown to increase testosterone secretion in males; this can help overcome impotence and will have an influence on muscular development. In the laboratory experiments, a 45″“ 90% increase in testosterone levels was found. Ginseng and deer antler have been used for centuries in Chinese remedies for menstrual disorders and for male impotence; this research confirms their efficacy. Luteinizing hormone is produced by the pituitary gland, so it is proposed that ginseng and deer antler ingredients do not have a direct hormonal action but instead influence the production of hormones by the body. In Italian studies of ginseng activity on the glands and hormone secretions in mice, the findings suggested that ginseng has a strong influence on the hypothalamus and pituitary glands, and that the adrenal effects of ginseng that are often noted were linked to these glands. Ginseng extracts of varying strength were given to normal rats and to rats who had their adrenal cortex removed. Based on the biochemical and histological evaluation of their spleen, liver, thymus, and other organs, it was suggested that ginseng induced the pituitary to release ACTH (a steroid hormone also produced by the adrenal cortex), which influenced the functions of the organs. It is generally agreed by researchers today that ginseng exerts its effects on what is called the “pituitary, hypothalamus, adrenal axis.” The term indicates the coordinated functions of these three glands in regulating metabolism, response, and homeostasis. Furthermore, this set of interacting glands may have been indirectly recognized for centuries by the Chinese as a functional unit influencing stress, aging, sexual function, and overall vitality. In the translation of Chinese medical terminology to Western terminology, this functional unit has been assigned to the “kidney.” Hence, one hears Chinese medical specialists frequently speaking of kidney functions we never otherwise associate with the kidney. In fact, the functional unit appears to rely heavily on the pituitary, hypothalamus, adrenal axis. As a result of the hormone research, we have a clearer picture of the ancient science of Oriental medicine. The hormonal effects are usually noted with higher dosages of ginseng. In one of the Swiss studies of athletes using relatively low ginseng dosage (equal to 1.0 grams of ginseng per day), hormone levels were monitored and no significant change was observed. Studies demonstrating a strong hormonal effect used the equivalent of about 3.0 grams per day of ginseng. During a double-blind study of the effects of ginseng conducted by the Institute for Traditional Medicine in the U.S., it was noted that large doses of ginseng (3.0″“4.5 grams per day) appeared to influence the menstrual cycle of women. Reports of altered cycle length or change in bleeding pattern during menstruation were made by 29% of the women receiving ginseng daily for three weeks. For the purpose of regulating menstruation, ginseng is usually combined with tang-kuei and other Chinese herbs, and not used alone.
CARDIOVASCULAR IMPACT
Until recently, Chinese dogma held that ginseng was to be reserved for those who were ill and for those who are showing the effects of aging. Korean and Japanese experience, however, suggests that ginseng can be taken everyday as a preventive health tonic. Now, research shows clearly that one need not be ill to use ginseng: even the healthiest among us may have cause to use it. Athletes, whether beginning joggers or Olympic contenders, agree that ginseng helps them overcome the strain and drain of exercise. A recent Swiss study conducted by Dr. Anton Kirchdorfer shows how ginseng helps. Thirty athletes were given exercise tests on a programmed exercycle to assure a specific level of muscle work. The heart rate and lactate concentration in the blood was measured before, immediately after, and for several minutes following the exercise. Strong exertion for eight minutes raised the athletes heart rate from an average value of about 70 to 155. During recuperation, their heart rate slowly returned to normal over a period of about 20 minutes; their heart rates fell below 100 after 4″“5 minutes. The athletes were then given ginseng daily for 9 weeks. The material used was a standardized extract of active constituents called “ginsenosides.” The tests were conducted again, using the same amount of exercise. Their pulse rates this time increased to only 140, and during recuperation their heart rates fell below 100 within just 3 minutes, and were back to normal in 5 minutes. Lactate (the by-product of muscular oxygen utilization that causes pain following exercise) was measured during the same tests. Before using ginseng, the lactate levels of the athletes increased from 2.0 before exercise to 10.5 afterwards, without returning to normal levels even after 20 minutes. Following 9 weeks of ginseng administration, lactic acid levels only reached 6.2 at their highest point, and decreased to normal in about twenty minutes. The lower heart rate and quicker return to normal suggests improved oxygen utilization and faster clearance of lactate. Additional measurements taken during this same research program demonstrated that reaction time was improved and pulmonary function was greatly enhanced. The effects of ginseng given for 9 weeks persisted for about three weeks after ginseng use was ceased. This persistence of herbal effects following long-term administration has been shown with other herb products. Traditionally, herbalists recommend a short break of one to two weeks when patients are using herbs for an extended period of time. This may be one way of getting the maximum advantage of the herbs used. The findings in this Swiss research are consistent with a previous double-blind study using the same ginseng extracts with 120 members of sports clubs. In that study, conducted by I. Forgo in Switzerland, significant improvements in pulmonary function, reaction time, and overall vitality (as self-evaluated) were found. These effects were especially noted in the 40″“60 age group, less so in the 30″“40 age group. The study lasted 12 weeks. The results obtained with athletes confirm laboratory animal studies that have been conducted in the past. Animals forced to perform vigorous exercise utilized less of their stored glycogen, fatigued less quickly, and generally performed better if they were first administered ginseng. Ginseng has been shown to increase the time which animals could keep up vigorous exercise by as much as 100%. Athletic-oriented research was conducted in China with tien-chi ginseng. Tien-chi ginseng is a close relative to ordinary ginseng, but it grows in a different climate, produces a harder root, and has somewhat different active constituents. The following is a summary of findings: 1. Under usual circumstances, pulse rates of weight lifters the morning after a day of intensive weight lifting did not return to normal levels. If they took tien-chi ginseng, on the other hand, their morning pulse did return to normal. 2. The pulse rate of swimmers following a medium-load training session was about 170, and after 2″“3 minutes rest, it was reduced to about 120. But if tien-chi ginseng was taken, the pulse right after swimming only reached about 125, and returned to normal rates (about 70) after 2″“3 minutes. 3. Differences between those not taking tien-chi ginseng and those taking tien-chi ginseng increased as use of the ginseng was continued over a longer period of time. The experiments were continued for 7 weeks (compared to 9 and 12 weeks for the Swiss studies). The study results with Panax ginseng and tien-chi ginseng are clearly similar to each other; further, they are similar to those obtained by Soviet researchers with eleuthero ginseng. Eleuthero ginseng is a distant relative of these plants; it is a woody shrub, with significantly different chemical constituents, but is used in much the same way as Panax ginseng. Soviet athletes regularly use eleuthero ginseng extract as a health tonic. With regard to oxygen consumption, these three types of ginseng have all been successfully tested in the treatment of oxygen deficit among Chinese workers transferred to the high plateau of Tibet (average altitude: 14,000 feet). This application follows up laboratory animal studies measuring response and survival rate of animals subjected to very low pressure atmosphere. Thus, it does not seem to be a critical concern as to which kind of ginseng is used for this purpose. Some athletes prefer to use several types of ginseng at once. Tien-chi ginseng has the advantage of resolving bruises and other injuries that often occur during sports activities, so it may be especially useful to those just starting an exercise program and those involved in more vigorous sports for that reason. It is gratifying for researchers to see human trials yielding results similar to those obtained during laboratory animal tests; this suggests that the models used in the laboratory were properly chosen.
THE ACTIVE CONSTITUENTS OF GINSENG
One problem with earlier ginseng research is that each scientist might utilize a different quality of ginseng and there may be no data indicating the content of the material that was used. Today, there are established chemical assays to assure that ginseng used in studies is of good quality. In fact, for the purpose of scientific precision, most researchers are using standardized ginseng extracts (the amount of selected active ingredients are standardized). Nearly all ginseng researchers claim that ginseng’s actions are attributable to the combined effect of its glycoside components called ginsenosides (they were previously called panaxosides). These components have a structure similar to steroid hormones, but as indicated by research cited above, they do not have a direct hormonal action; rather, they influence the production of hormones. Eleutherosides, the glycoside components found in eleuthero ginseng, generally do not have a steroid structure. There are at least ten ginsenosides present in Panax ginseng and tien-chi ginseng in quantities that can have a notable physiologic effect. Eleuthero ginseng contains at least seven eleutherosides. If the ginsenosides are isolated individually and tested in laboratory animals, it is found that each has a somewhat different, and sometimes opposite effect. The balancing action of ginseng””for example, lowering blood pressure in those with hypertension and raising blood pressure in those with hypotension””is thought to be due to the complex interaction of different glycoside effects. Thus, to get the desired balancing action of ginseng, it is necessary to utilize the complete set of glycosides. Depending upon the species of ginseng and other factors, its content of glycosides ranges from about 4% to 12% (tien-chi ginseng has the highest levels). White ginseng has the lowest levels of ginsenosides because, during the drying process, enzymes in the ginseng roots break down these active ingredients. Red ginseng is prepared by a steaming process that prevents this breakdown of constituents. Ginsenoside content, both total amount and distribution amongst the different types of ginsenoside, is used as a measure of ginseng quality. Chinese researchers working with flowers of eleuthero ginseng at the Department of Pharmacology, Shanghai College of Traditional Chinese Medicine, demonstrated that the oil fraction had a high activity in reducing stress. Laboratory animals exposed to low oxygen environment or high levels of physical activity performed much better if they received eleuthero flower oil than if they did not. Thus, the oil components, which are different than the glycosides, may be of importance. All parts of the ginseng plant contain a small amount of oils. Furthermore, polysaccharides have been isolated from ginseng and eleuthero ginseng. These components are valuable in enhancing immune system functions. Polysaccharides of similar nature found in medicinal mushrooms such as ganoderma and shiitake, and in Chinese herbs with actions similar to ginseng, such as astragalus, have all been shown to boost weakened immune responses. It is important to note that the same polysaccharides that enhance immune responses also tone down aberrant immune responses associated with autoimmune diseases. Interestingly, a plant unrelated to ginseng, Gynostemma pentaphyllum, was recently shown to contain several ginsenosides. This plant has become an important therapeutic agent in China during the 1990’s, being used to help improve immune system functions in cancer patients. The clinical benefits of this herb suggests that the ginsenosides are the most important of the immune-enhancing agents in ginseng.
From the information presented above, it should be evident that ginseng is to be taken for a period of time before one expects to see substantial results. Some people experience immediate effects, but in general, the use of a ginseng product should continue for at least one week to one month before one looks for notable changes in health and performance. A two to three month period of use may be ideal. Nearly everyone can use ginseng, but experienced Chinese herbalists recommend that persons with the following conditions do not use ginseng except under the advice of a professional: persons with extremely high blood pressure, those who tend to get spontaneous nose bleeds, women with excessive menstrual bleeding, and persons who experience a hot and dry feeling frequently. Ginseng is one of the few Oriental herbs that can be used by itself with good results. However, outside of Korea, where it is frequently used as a single herb remedy, ginseng is most often used in combination with other herbs.
Effects of Ginseng from Earlier Research Studies
Blood Pressure: hypertension patients experience a reduction of blood pressure using low to moderate doses of ginseng; hypotensive patients experience an increase of blood pressure using moderate to large doses of ginseng.
Blood Sugar: diabetic patients experience some lowering of blood sugar with prolonged use; at least one month.
Central Nervous System: calming action in cases of insomnia in low dosage, stimulant action in cases of lethargy, poor digestion, chill, and mental dullness in larger doses.
Stress: reduces stress reaction, including depletion of vitamin C, glycogen, and protein, and preserves life against many physical (e.g., temperature, low oxygen, radiation), chemical (e.g., liver toxins), and biological (e.g., viral) stresses.
Active Constituents of Ginseng
Panaxosides and Eleutherosides: these are glycosides that have been intensively studied. They seem to have many of the central nervous system and cardiovascular effects.
Polysaccharides: these are highly branched chains of sugar molecules; they appear to have a normalizing effect on immune system functions.
Phenolic Compounds, other complex alcohols, and organic acids: these have been recently studied; it is suggested that they contribute an anti-aging effect and reduce fatigue.
Fixed and Volatile Oils: these have an anti-stress effect and are sedative in nature.
Vitamin and Mineral Components: ginseng contains B vitamins and a number of minerals; however, it is unlikely that the amounts contained in the average daily dose of ginseng have much health impact. Nonetheless, ginseng can be classified as a nutritious food. Some authorities believe that ginseng was originally eaten raw or in soups as a food which provided energy and quenched thirst.

Dose: 1-9g (or more for shock) For Qi collapse, cook 30-60g for one hour and drink

 
Ren Shen Lu: the neck/head of root
• Mild emetic (rare use): used to induce vomiting to eliminate phlegm for epilepsy.
• Also for food stagnation and phlegm with deficiency.

 
Ren Shen Ye: the leaf
• Bitter, slightly sweet, cold.
• Clears summer-heat; generates body fluids.
• Treats deficiency heat/fire.
• Summer-heat with thirst.
• Injury to fluids from febrile disease.
• Lung heat: hoarseness.
• Stomach Yin deficiency fire: toothache.
• Drunkenness.

Shan Yao – Dioscorea opposita tuber – Chinese Yam – “Mountain Herb”

Nature: sweet, slightly astringent, neutral

Enters: Spleen, Lung, Kidney

Actions: Tonifies spleen, stomach, Lung, and kidney Qi and Yin; slightly controls body fluids; benefits both the Yin and the Yang of the Lungs and kidneys.

Indications:
• Spleen Qi deficiency: poor appetite, loose stool, fatigue, spontaneous sweating.
• Lung Qi/Yin deficiency: cough, difficulty breathing.
• Kidney Qi deficiency: seminal emission, copious leukorrhea, frequent urination.
• Slowly lowers blood sugar.
• For diabetes (Lung, stomach, kidney Qi deficiency or Qi and Yin deficiency): up to 250g per day, decocted and taken as a tea.
• Powder and make into jook to build spleen Qi and appetite.
• Use raw to tonify the Yin, dry-fry to strengthen the spleen.
• In some damp patients, Shan yao’s astringent quality contraindicates its use.
Li: Useful for nasal dripping – astringes.
PLB: Recent studies indicate that orally consumed diosgenin is not converted to progesterone in the human body. Does not have hormonal effects.
Yoga: Aluka: V, P-; K+ (in excess)
• Nutritive tonic, aphrodisiac, rejuvenative, diuretic, antispasmodic, analgesic.
• For impotence, senility, hormonal deficiency, infertility, colic, nervous excitability, hysteria, abdominal pain, cramps.

Dose: 9-60g (up to 250g/day for wasting and thirsting disorder)

Tai Zi Shen – Pseudostellaria root – “Prince Root” or “Child Root” or “Son of the Emperor Root”

Nature: sweet, slightly bitter, neutral

Enters: Spleen, Lung

Actions: Tonifies Lung Qi and spleen Qi; produces body fluids.

Indications:
• Spleen and Lung Qi deficiency: poor appetite, fatigue, palpitations, spontaneous sweating.
• Lung deficiency, dryness, heat: cough and thirst.
• Qi and yin deficiency: thirst, palpitations, insomnia. Treats chronic febrile disorders.
• Especially indicated for those who are so deficient that they can’t assimilate stronger/richer tonics; also commonly used for those recuperating from chronic illness. [Chen & Chen]
• Commonly used for Spleen Qi deficiency with Stomach yin deficiency.
• Thirst and injury to fluids after a febrile disease.
• Unrelenting fever or summer-heat in children.
• Specifically considered a weak Qi tonic (yet not inexpensive)
• Used with Wu wei zi to treat “neurasthenia”: fatigue, lassitude, depression, anxiety, etc.
• For poor appetite due to Spleen and Stomach deficiency, combine with Bai zhu and Gu ya.
• For acute or chronic hepatitis, combine with Wu wei zi and Yu mi xu.
• For insomnia and palpitations due to Qi and Yin deficiency with heat, combine with Wu wei zi, Suan zao ren, and Bai zi ren.
• For thirst due to Qi and Yin deficiency with heat, combine with Sheng di, Zhi mu, Mai men dong.
• For dry cough due to heat drying Lung fluids, combine with Sha shen, Bai he, Mai men dong, and Bei mu.
• Similar to Xi yang shen, but gentle – weaker than Xi yang shen at tonifying both Qi and Yin, but a reasonable substitute for mild cases of Qi and Yin deficiency.
• Can often be used as a substitute for Ren shen, especially in cases of liver Yang rising.
• Contraindicated for use with Li lu.
MLT: Very similar to Starflower (Trientalis borealis) of the Pacific Northwest United States.

Dose: 9-30g

Notes on This Category

• Herbs in this category are rich and tend to be greasy. Use caution when there is accumulation of dampness in the middle Jiao.
• These herbs are commonly combined with Qi tonics since Qi is necessary for blood production. They may also be combined with herbs to support their digestion (e.g., sha ren, chen pi, mu xiang, ji nei jin, shen qu, etc.) by promoting Qi circulation in the middle jiao.

The two major approaches to nourishing blood are:
1. Build blood directly with blood tonics.
2. Strengthen the digestive system (spleen Qi) to enhance the body’s own production of blood.
(A formula such as Dang Gui Bu Xue Tang, which is just Huang Qi [30g] and Dang Gui [9g], is a simple example of both approaches.)

• Also consider, as appropriate: Qi tonics, Yin tonics, Jing tonics; Gou qi zi, Sang shen, Bai zi ren, Ji xue teng, Dan shen, etc.

Bai Shao Yao – White Peony root – Paeonia lactiflora

Nature: bitter, sour, slightly cold

Enters: Liver, Spleen

Actions: Nourishes blood; astringes Yin; softens the liver (by nourishing and astringing liver blood); relieves pain; subdues liver Yang rising; regulates the menses; adjusts the Ying and Wei; separates a mixture of Yin pathological factors.

Indications:
• Blood deficiency: irregular menstruation, abdominal cramps during menstruation, uterine bleeding, vaginal discharge.
• Yin deficiency leading to floating Yang: night sweats, spontaneous sweating.
• Liver blood deficiency: hypochondriac pain, costal pain, spasm in the limbs.
• Liver Qi stagnation, liver attacking the spleen/stomach: flank, chest, epigastric, or abdominal pain.
• Liver Yang rising: dizziness, headache.
Ying/Wei disharmony: exterior wind-cold from deficiency patterns with continuous sweating that does not resolve the problem.
• Painful spasms in the abdomen, cramping pain or spasms in the hands and feet, abdominal pain associated with dysenteric disorders.
• Vaginal discharge, spermatorrhea.
• The liver, the general, can easily become stiff, stagnant, overpowering – Bai shao softens it.
• This herb has a downward energetic.
• May lower blood pressure.
• Use raw to pacify the liver. Dry-fry the herb to nourish the blood and harmonize the Ying and Wei.
• Never to be combined with Li lu.
• Compared to Dang gui, both are used for pain and blood deficiency patterns. Bai shao is more appropriate for blood deficiency accompanied by heat, while Dang gui is used more for blood deficiency accompanied by cold.

• In many older sources, the name “Shao Yao” is used without differentiating between Chi Shao Yao (red peony root) and Bai Shao Yao (white peony root). Some sources say the difference is the flower color (red versus white) and others say that the medical product Chi Shao is reddish in color while the product Bai Shao is white (this may be actually due entirely to processing methods). According to the folks at NuHerbs, Bai Shao is Paeonia lactiflora with or without the “skin” on it. Their Japanese customers always requested it with the skin (making it look like what many of us believe to be Chi Shao) because they insisted that the skin is the most medicinal part. Upon lab testing it, NuHerbs found that their samples of Bai Shao with the skin removed (what most companies sell) failed quality standards, and they moved to always source the herb with the skin. Chi Shao is actually a different species – Paeonia veitchii. It lacks Bai Shao’s blood nourishing effect (some sources say it does have a weak blood nourishing effect), but is much more cooling (clears heat and cold the blood) and has the additional quality of being able to move blood (it is classified either as a blood mover or a heat-cearing & blood-cooling herb). Some sources also say that Bai Shao has some (mild) ability to move the blood.

MLT: Antispasmodic, blood moving.
• King’s American Dispensatory (Lloyd/Felter)lists indications of this herb as “chorea, epilepsy, spasms, various nerve affections”
PFGC: Can astringe heat that has floated to the upper warmer and entice it down and drain it via urine.
• Due to its bitter essence, it can enter the gallbladder and boost bile production.
• Excellent at purging liver/gallbladder heat, eliminating tenesmus in dysentery or treating eye disorders involving swelling and pain.
• With Fu zi, it can astringe escaping original Yang and entice it back to the lower Jiao (must use a high dose of Bai shao in this case).
HF: A supplement with an anti-Gu nature, possessing acrid, toxin-resolving qualities, useful in Gu Zheng (Gu parasites) formulas.
Hsu: Anti-spasmodic, analgesic, CNS sedative, antibacterial, may help prevent development of gastric ulcer.
DY: Harmonizes the constructive Qi; constrains and protects Yin; nourishes the blood and constrains Yin without attracting nor blocking evils in the interior; nourishes stomach Yin; relieves tension, stops pain; tropism: the Yin division.
• With Chai hu to drain the liver without damaging liver Yin, nourish the liver without causing liver depression Qi stagnation, regulate the spleen, stop pain effectively, harmonize the interior and exterior, and constrain Yin while upbearing Yang. For such indications as:
– 1. Liver depression Qi stagnation causing disharmony between Qi and blood.
– 2. Vertigo, unclear vision, chest and lateral costal oppression, pain, and distention due to liver depression Qi stagnation or to disharmony between the exterior and interior.
– 3. Menstrual irregularities, dysmenorrhea, breast distention, low-grade fever during the menses, premenstrual syndrome, and fibrocystic breasts, all caused by liver depression Qi stagnation or disharmony between the liver and spleen.
• The combination of Bai shao and Chai hu is effective for the treatment of liver and digestive problems caused by liver depression Qi stagnation or liver-spleen or liver-stomach disharmony, such as subacute or chronic hepatitis, hepatomegaly, cholecystitis, gallstones, enteritis, and colitis.
• With Chi shao to nourish the blood, constrain Yin, stop pain, cool the blood without causing blood stasis, and drain and nourish the liver. For indications such as:
– 1. Persistent low-grade fever due to heat in the blood. (Add Sheng di, Di gu pi, and Mu dan pi.)
– 2. Dry mouth and tongue, red and painful eyes due to insufficiency of fluids or Yin caused by residual heat. (Wine mix-fry both herbs and add Xiang fu and Dang gui.)
– 3. Lateral costal and chest pain, abdominal pain and conglomerations due to blood stasis or liver depression Qi stagnation.
– 4. Menstrual irregularities or amenorrhea caused by blood stasis, blood deficiency, and/or liver depression Qi stagnation.
• With Gan cao to engender Yin (sour + sweet), calm the liver, fortify the spleen, supplement Qi and blood, harmonize the liver and spleen, soothe the sinews, and stop pain. In this combination, 6-10g Gan cao and 10-15g (up to 60g) of Bai shao can be used. For indications such as:
– 1. Weakness in the lower limbs and spasms and pain in the limbs due to disharmony between the Qi and the blood which causes inadequate nourishment of the sinews and vessels.
– 2. Abdominal pain due to liver-spleen disharmony. If either disorder is accompanied by cold signs, use wine mix-fried Bai shao and mix-fried Gan cao. If the disorder is accompanied by heat signs, use raw Bai shao (or Chi shao) and raw Gan cao.
– 3. Headaches due to blood deficiency. (Add He shou wu, Bai ji li, and Jiang can.)
• The combination of Bai shao and Gan cao is very effective for numerous problems accompanied by spasms and pain, such as gastritis or colitis, spasm of the gastrocnemius muscle in the leg, contraction of the limbs, tendinitis, lateral costal pain, and hiccups or stubborn vomiting caused by spasm of the diaphragm.
• With Gui zhi to harmonize Yin and Yang, the Qi and the blood, and the constructive and the defensive. This combination drains without damaging Yin, while constraining without retaining evils. They harmonize the vessels, relieve tension and stop pain, as well as support stomach Yin and spleen Yang, while regulating the spleen and stomach. For indications such as:
– 1. Common cold with fever, shivers, slight perspiration, no thirst, headache, thin white tongue fur, and a floating, moderate pulse or, in other words, a wind-cold exterior pattern with disharmony between the constructive and the defensive. (Take Gui Zhi Tang. 10 minutes later, eat very hot rice porridge, and stay well covered in bed to promote perspiration.)
– 2. Spontaneous perspiration and/or night sweats accompanied by fear of wind and cold, a cold feeling in the low back, and frequent catching of colds due to disharmony between the constructive and the defensive. (Use stir-fried Gui zhi.)
– 3. Chest and cardiac area pain due to heart Yang deficiency and disharmony between the Qi and blood. (Use 15-30g Gui zhi. In case of very cold limbs, Fu zi can be added.)
– 4. Abdominal pain with spasms and cramps due to deficiency cold and disharmony between the Qi and blood. (Dose Bai shao:Gui zhi::2:1. Use honey mix-fried Gui zhi and wine mix-fried Bai shao.)
– 5. Pain and/or numbness of the limbs due to disharmony between the Qi and blood. (Use stir-fried Gui zhi and wine mix-fried Bai shao.)
– 6. Vomiting and weakness during pregnancy accompanied by fear of cold, lack of appetite, nausea and a weak pulse in the cubit position due to disharmony of the spleen and stomach and the constructive and defensive. (Use stir-fried Gui zhi and wine mix-fried Bai shao.)
– 7. Weakness in the elderly, during convalescence, postpartum, and post-operatively with fatigue and lack of strength, fear of wind, and slight perspiration due to disharmony between the constructive and the defensive. (Use stir-fried Gui zhi.)
• In cases of vertigo, uncooked Bai shao should be used.
• In cases of liver-spleen disharmony causing diarrhea, Bai shao should be stir-fried until yellow.
• In cases of gynecological problems, wine mix-fried Bai shao should be used.
• In cases of chest or lateral costal pain, abdominal pain, or pain in the stomach area, wine mix-fried Bai shao should be used.

Dose: 6-30g

Dang Gui – Angelica sinensis root – “State of Return”

Nature: sweet, acrid, warm

Enters: Liver, Heart, Spleen

Actions: Nourishes blood; promotes blood (and Qi) circulation; harmonizes the blood; relieves pain; moistens the large intestine; regulates the menses; disperses cold; reduces swelling; expels pus; generates flesh.

Indications:
• For any form of blood deficiency.
• Blood deficiency and stagnation: irregular menses, dysmenorrhea, amenorrhea.
• Blood deficiency: ashen face, tinnitus, blurry vision, palpitations.
• Blood deficiency with chronic wind-damp Bi syndrome.
• Blood deficiency and cold: abdominal pain.
• Blood stasis (especially with cold from deficiency): pain, traumatic injury, Bi, carbuncles/boils.
• Blood deficiency leading to large intestine dryness: constipation.
• Useful for some sores or abscesses (where blood deficiency and stasis are involved).
Dang gui’s combination of nourishing and moving qualities means that it can nourish blood without blocking it and it can move blood without depleting it.
• Injected into acupoints in China for pain (neuralgias, ischemic, arthritis – this form of therapy is not used for acute pain, tumors, infections).
• May reduce vascular plaque formation.
• Compared to Bai shao, both are used for pain and blood deficiency patterns. Bai shao is more appropriate for blood deficiency accompanied by heat, while Dang gui is used more for blood deficiency accompanied by cold.
• Doctrine of signatures (to my eye, anyway [PLB]): shaped like a uterus.
• The four parts of Dang gui:
Dang Gui Tou: head of the root. Most tonifying, less ability to promote blood circulation. DY: Quickens the blood and stops bleeding. Often stir-fried until carbonized to reinforce its hemostatic action.
• Dang Gui Shen: body of the root. Slightly more tonifying than moving.
• Dang Gui Wei: tail of the root. More moving than tonifying. DY: Quickens the blood and breaks blood stasis. This part if often wine-processed to reinforce its action.
Dang Gui Xu: the beard of Dang gui – the rootlets of the main and secondary roots. DY: Dang gui xu quickens the blood and frees the flow of the network vessels. This part is often wine-processed to reinforce its action.
Quan Dang Gui: the entire root, which includes the four parts mentioned above. DY: It harmonizes the blood. Li Dong Yuan said, “The head stops bleeding and is directed upwards. The body nourishes the blood and is fixed to the center. The tails break the blood and flow downward. The whole root quickens the blood and treats everything.”
MLT: Rich in nutrients, including vitamin B-12, folic acid, biotin.
• Stimulates hematopoeisis; also has antiplatelet action.
• One compound stimulates the uterus while another relaxes it and increases DNA synthesis and growth of uterine tissue.
• For all forms of anemia, including pernicious.
BII: Regulates estrogen, tones the uterus.
Yoga: Choraka: VPK=; P+ (in excess)
• Tonic, emmenagogue, rejuvenative (especially for Vata), diaphoretic, antispasmodic, analgesic, anti-arthritic.
• Topical: for wounds, ulcers, itching, and to nourish and beautify the skin.
Hsu: The non-volatile water-soluble compounds stimulate uterine muscle, while the volatile oil inhibits (relaxes) uterine muscle.
• Therefore, to contract the uterus, decoct for a long time (cook off the volatile oil).
• To relax the uterus, add Dang gui at the end and cook over low heat and/or for short duration.
PFGC: Li Dong Yuan said the head of Dang gui controls bleeding and entices its effect to go upward, the body nourishes blood and keeps its effect in the central region, and the tail cracks blood and causes its effect to go down. The entire plant [taken as a whole] vitalizes blood but does not much move around the body.
• With Chuan xiong, Dang gui gains the momentum of budding growth and nourishment.
• With Bai shao, the combination is an essential remedy to rescue Yin and astringe Yang.
Dang gui can harmonize blood in cases of Qi rebellion resulting in coughing – once the blood is harmonized, the Qi will descend.
Dang gui can disperse cold stasis causing diarrhea, abdominal pain, lumbar pain, or headache.
• For disorders of the Chong Mai manifesting in Qi counterflow and internal distress.
• Disorders of Dai Mai manifesting in abdominal pain and a sensation of the lumbar region being submerged in water.
• Dry skin due to undernourished flesh and muscles.
• Can moisten Lung dryness, can smooth aggravation of liver wood.
• Its moistening effect reaches all tissues and muscles.
• Can move blood and control bleeding – useful for hematemesis and epistaxis (for this use, it is best to fry it in vinegar to emphasize its descending effect.
• Its ability to disperse the surface is weak, but it is still an excellent remedy to dispel wind (by moving blood) – good for post-partum seizures.
HF: A supplement with an anti-Gu nature, possessing acrid, toxin-resolving qualities, useful in Gu Zheng (Gu parasites) formulas.
DY: Dispels stasis; downbears the Qi, stops cough, and calms asthma.
Dang gui is probably the best Chinese herb for treating blood stasis due to blood deficiency or accompanied by blood deficiency.
Dang gui, or rather Quan dang gui (whole Dang gui), harmonizes the blood. Harmonizing the blood is a term which (in the Chinese materia medica) is almost specific to Dang gui. This is because Dang gui is one of the few medicinal substances which nourishes and moves the blood simultaneously (other substances which possess both properties only mildly nourish the blood).
• To stop cough and calm asthma, the whole herb (Quan dang gui) should be used.
Dang gui and Shu di are probably the two most effective medicinal substances for treating constipation due to blood deficiency. Dang gui you, the oil extracted from Dang gui, is particularly indicated for nourishing the blood, moistening dryness, moistening the intestines, and promoting defecation.
• With Chuan xiong to move the Qi and quicken the blood without damaging the blood, to nourish the blood without producing stasis, to dispel stasis and stop pain. For the following indications, both herbs should be wine-processed, though uncooked Chuan xiong may be used in the case of headaches or dermatological problems:
– 1. Menstrual irregularities, dysmenorrhea, and postpartum abdominal pain due to blood stasis that may be mixed with Qi stagnation. (Xiong Gui San)
– 2. Rheumatic pain due to wind-dampness and blood vacuity.
– 3. Headaches due to blood deficiency and/or blood stasis. (Jia Wei Si Wu Tang)
– 4. Wounds, ulcers, or enduring cutaneous inflammations due to Qi and blood vacuity with Qi and blood stagnation. (Tou Nong San)
• With Huang qi to supplement the Qi to strongly engender and transform blood, to effectively supplement the Qi and blood. For the following indications, wine mix-fried Dang gui and honey mix-fried Huang qi should be used. Also, the whole Dang gui root (Quan dang gui) or the body of Dang gui (Dang gui or Dang gui shen) should be used. The dosage of Dang gui for the following indications should be relatively low if there is Qi deficiency and weakness in the middle burner.
– 1. Delayed menstruation (a long cycle), postpartum weakness, agalactia due to Qi and blood deficiency. (Shi Quan Da Bu Tang)
– 2. Low-grade fever caused by blood deficiency. (Dang Gui Bu Xue Tang) Wu Kun of the Ming dynasty said, “When the blood is full, the body is cool. When the blood is vacuous, the body is warm.”
– 3. Sores and welling abscesses that do not heal, due to blood and Qi deficiency. (Tou Nong San)
– 4. Numbness of the limbs due to deficient blood not nourishing the sinews.
– 5. Various hemorrhages due to Qi not containing the blood within the vessels. (Dang Gui Bu Xue Tang)
• With Shu di to nourish blood, enrich Yin, supplement the liver and kidneys, downbear the Lung Qi and promote Qi intake by the kidneys, stop cough, and calm asthma. For indications such as:
– 1. Chronic cough and/or asthma due to Yin deficiency of the kidneys associated with blood deficiency. If there is blood deficiency, Qi lacks its root. This can create an imbalance in the upbearing and downbearing function of the Qi with Lung Qi deficiency. If the kidneys are weak, they cannot insure their function of Qi intake. This then results in Qi counterflow and asthma. For these indications, this combination can be found in Jin Shui Liu Jun Jian.
– 2. Blood deficiency. (Si Wu Tang)
– 3. Constipation due to blood deficiency.
PCBDP: In a clinical trial, it was shown to be effective in improving abnormal protein metabolism in 60% of patients with chronic hepatitis or cirrhosis of the liver, and it increased the erythrocyte and platelet count in many patients.

Dose: 3-15g

E Jiao – Ass Hide Gelatin

Nature: sweet, neutral

Enters: Lung, Liver, Kidney

Actions: Stops bleeding; nourishes blood; nourishes Lung Yin and moistens the Lungs.

Indications:
• Any bleeding leading to blood deficiency: hematemesis, hemafecia, epistaxis, uterine bleeding, consumptive disorders with coughing of blood.
• Blood deficiency: dizziness, palpitations, sallow face, vertigo, insomnia.
• Liver Yin deficiency: restlessness, insomnia.
• Lung Yin deficiency: dry cough, asthma.
• Increases WBC’s for cancer, anemia.
• Greasier than Shu di (commonly combined with herbs such as Pei lan, Huo xiang, etc.).
• The substance of choice for blood deficiency with concurrent loss of blood.
• Usually dissolved into a strained decoction or wine, or used in pills.
MLT: Regularly taken by older women to counteract symptoms of dryness associated with aging.
Hsu: Aids in blood clotting, increases RBC count and amount of hemoglobin in the blood, aids against shock due to external wounds.
DY: With Huang lian to drain fire and enrich Yin according to the method of draining the south (i.e. fire) and supplementing the north (i.e. water), reestablish the interaction between the heart and kidneys, quiet the spirit, and treat dysentery damaging Yin. For indications such as:
– 1. Vexation, agitation, and insomnia due to febrile disease which has damaged Yin, deficiency fire, or heart and kidneys not communicating. (Huang Lian E Jiao Tang) Unprepared, or, even better, wine-processed Huang lian should be used.
– 2. Dysentery which damages Yin with pus and blood in the stools due to damp-heat in the large intestine.
– This is a key pair for heart-kidney disharmony, with symptoms mentioned above, plus many psychological disorders, loss of memory, profuse dreams, and tendency to wake up easily and frequently.
• Some treatises say that when E jiao is stored and aged, it is of superior quality. It is then called Chen e jiao.
E jiao has a remarkable ability to promote red blood cell production.

Dose: 3-15g

He Shou Wu – Polygonum multiflorum root – “Mr. He’s Black Hair”

Nature: bitter, sweet, astringent, slightly warm

Enters: Liver, Kidney

Actions: Nourishes blood; augments the Jing; secures the Jing and stops leakage; tonifies the liver and kidneys; eliminates toxicity and treats malaria; relieves fire toxicity; moistens the large intestine and promotes bowel movement; eliminates internal wind and expels wind from the skin (through nourishing blood).

Indications:
• Jing and blood/Yin deficiency: dizziness, blurry vision, early greying of the hair, weakness of the lumbar region and knees, soreness in the extremities, insomnia, seminal emission, uterine bleeding.
• Jing leakage: nocturnal emission, premature ejaculation, vaginal discharge.
• Jing and blood deficiency: chronic malaria, carbuncles, lumps, constipation.
• Fire toxicity: carbuncles, neck lumps, goiter, sores, scrofula.
• Blood deficiency: wind rash with itching.
• Bensky/Gamble: compared to Shu di, He shou wu is thought to focus more on the liver, while Shu di focuses more on the kidneys.

• This herb causes liver damage in some users, especially with longer-term use (1 month or more) and high doses. Click here for one of several studies: Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series 

• When He shou wu is prepared with black beans, its action is focused more on the kidneys.
He shou wu is drier than Shu di. It does not have Shu di’s viscous, cloying properties, does not impair digestion, and is acceptable for use with mild dampness.
• Weaker than Shu di at nourishing blood, stronger than Shu di at nourishing Jing.
• Use the prepared form to nourish Jing and blood and tonify the liver and kidneys.
• Use the dry form to moisten the large intestine for constipation and for its anti-inflammatory action.
• Lowers serum cholesterol.
• Widely used for hypertension and coronary heart disease.
• Do not cook this herb in a steel vessel – it alters the chemistry of the herb.
• This herb is also known (mistakenly) as Fo ti tieng.
MLT: Often steamed with black soy beans and yellow rice wine (giving it a reddish-brown color) to increase its tonic properties.
• Its chemistry resembles human adrenocorticoids.
• Contains much lecithin (may be responsible for the herb’s cholesterol-controlling effects).
• Reduces the heart rate while slightly increasing circulation of blood through the heart.
• Very good for lumbar pain from blood/Jing deficiency.
HF: A supplement with an anti-Gu nature, possessing acrid, toxin-resolving qualities, useful in Gu Zheng (Gu parasites) formulas.
BF: In He Shou Wu Lu (Song of He Shou Wu), it is said that this herb boosts the Qi.
• In Dian Nan Ben Cao, it is said that this herb astringes the Jing and hardens the kidneys.
• In Kai Bao Ben Cao, it is said that this herb mainly treats scrofula, disperses welling abscesses and swellings, treats head and face wind sores and the five kinds of hemorrhoids, stops heart pain, boosts the blood and qi, blackens the hair, brightens the color of the cheeks, and also treats various women’s postpartum and abnormal vaginal discharge diseases (several of these patterns involve damp-heat).
Yoga: Decreases Pitta and Vata; increases Kapha and ama (when used in excess)
• Tonic, rejuvenative, aphrodisiac, astringent, nervine.
• For anemia, neurasthenia, impotence, low back pain, enlarged lymph glands, arteriosclerosis, diabetes.
• With Gotu kola to counteract aging (He shou wu for the tissues, Gotu kola for the mind).
Hsu: Purgative (by anthraquinone derivatives) – stimulates intestinal peristalsis; inhibits increase in serum cholesterol, decreases absorption of cholesterol from the alimentary canal, prevents retention of lipid in serum or inhibits deposition of lipid on inner membrane of arteries; antiviral; cardiotonic.

Dose: 9-30g

Long Yan Rou – Longan fruit (Euphoria longan) – “Dragon Eye Flesh”

Nature: sweet, warm

Enters: Heart, Spleen

Actions: Tonifies Qi and nourishes blood of the Spleen and Heart; calms the Shen.

Indications:
• Heart and Spleen blood and Qi deficiency: insomnia, palpitations, poor memory, dizziness, excessive worry, fatigue. Can be used alone to nourish the Heart and Spleen. Despite its sweetness, it’s not stagnating in nature. May also be combined with Ren shen, Huang qi, Dang gui, Suan zao ren for this condition (or Gui Pi Tang).
• Qi and blood deficiency: fatigue, weakness, shortness of breath, spontaneous sweating, pale or sallow complexion (commonly seen in chronic illness and elderly).
• Especially for problems associated with excessive pensiveness or overwork.
• For diarrhea due to Spleen deficiency, combine with Sheng jiang, Bai zhu, Shan yao, and Yi yi ren.
• For edema in post-partum women, combine with Sheng jiang and Da zao.
• Like other moistening tonic fruits Sang shen and Gou qi zi, Long yan rou can be safely taken over a long period of time.
• Often eaten alone or taken as an infusion.
• Soaked in grain-based liquor to make a tincture, used for Qi & blood deficiency with cold due to Yang deficiency (drink daily). Also for insomnia from deficiency and cold, take a small portion before sleep.
LL: Very warm. Not for heat patterns except when combined appropriately.

Dose: 6-15g (to 30)

Part One Begins Here – Herbs That Quiet the Shen and Nourish the Heart

Herbs in both parts of this category (nourishing herbs that quiet the shen and heavy/anchoring herbs that quiet the shen) are commonly combined with:
A. Herbs that nourish blood and Yin when there is Yin or blood deficiency of the heart.
B. Herbs that clear heat from the heart when there is excess heart heat or fire.
C. Herbs that subdue liver Yang when there is liver Yang rising.
D. Herbs that clear heat from the Stomach, when there is Stomach heat/fire disturbing the Shen.

 

Also Consider, When Appropriate, Herbs From Other Categories That Nourish and Quiet or Anchor the Shen:
Bai He [Nourish Yin], Da Zao [Tonify Qi], Dai Zhe Shi [Subdue Liver], Dan Shen [Move Blood], Fu Ling/Shen [Drain Damp], Fu Xiao Mai [Astringent], Lian Zi [Astringent], Long Yan Rou [Nourish Blood], Mu Li [Subdue Liver], Ren Shen [Tonify Qi], Shi Chang Pu [Open Orifices], Tian Zhu Huang [Resolve Phlegm], Wu Wei Zi [Astringent], Xi Xian Cao [Expel W-D], Xi Jiao [Cool Blood], Zhen Zhu [Subdue Liver],  Zhen Zhu Mu [Subdue Liver].

Bai Zi Ren – Biota seed = Thuja orientalis = Platycladus – Chinese Arborvitae

Nature: sweet, neutral

Enters: Kidney, Large Intestine, Heart, Spleen

Actions: Nourishes heart blood; quiets the Shen; moistens the large intestine, promotes bowel movement.

Indications:
• Heart blood deficiency: insomnia, palpitations, forgetfulness, anxiety, irritability (most effective herb for heart blood deficiency insomnia).
• Large intestine dryness due to Yin or blood deficiency: constipation, especially in the elderly, debilitated, and in post-partum women.
• Yin deficiency: night sweats.
• More oily than Suan zao ren – caution with loose stools, phlegm.
• This herb must be crushed before cooking.
• When used topically, it is dry-fried until the oil seeps out.
DY: Supplements heart Qi and blood; quiets the Hun, Po, and Shen; boosts the intelligence.
• With Suan zao ren for mutual reinforcement, to effectively nourish both the liver and the heart, tranquilize the heart, and quiet the spirit. For indications such as:
– 1. Palpitations, profuse dreams, and insomnia due to heart blood (and Qi) deficiency. (Tian Wang Bu Xin Dan) Defatted Bai zi ren and stir-fried Suan zao ren should be used.
– 2. Constipation with dry stools due to blood deficiency and intestinal fluid insufficiency.

Dose: 6-18g

He Huan Pi – Albizzia bark – Mimosa tree – “Collective Happiness Bark”

Nature: sweet, neutral

Enters: Heart, Liver

Actions: Quiets the Shen; relieves mental stress and depression; relieves constraint; promotes blood circulation; dissipates swelling; alleviates pain; calms the five organs and promote happiness.

Indications:
• Anger, restlessness, insomnia, poor memory, constrained emotions, irritability (when using it for insomnia, it is especially indicated when due to Qi problems [usually constraint]).
• Blood stasis: trauma, carbuncle, internal abscess, pain and swelling.
Li: Nourishes heart blood.
Hsu: Tonic, stimulant, analgesic, anthelmintic, diuretic, oxytocic action.

Dose: 9-30g

 
He Huan Hua: the flower
• Sweet, neutral.
• Same functions as the bark, though generally stronger overall, more moving to the Qi, and promotes the free flow of stagnant liver Qi.
• Primarily for depression, constrained emotions, irritability, insomnia, especially when accompanied by epigastric pain and feelings of pressure in the chest.
• There are at least four different plants used as this herb, including albizzia flower, which consists of many pink hairs when fresh and becomes brown when dry, and several unrelated others. Many practitioners prefer the substitute species to the “true” herb.

Dose: 6-15g

Ling Zhi – (Chi Zhi, Dan Zhi) – Ganoderma mushroom – Reishi

Nature: bitter, sweet, warm

Enters: Heart, Liver, Lung

Actions: Chen: Nourishes the heart and calms the Shen; stops coughing and arrests wheezing, dispels phlegm; tonifies Qi and nourishes blood.

Indications:
• Restless Shen, spleen Qi and heart blood deficiency: insomnia, forgetfulness, fatigue, listlessness, poor appetite.
• Cough and asthma, difficulty sleeping due to dyspnea, profuse sputum. With Ku shen and Gan cao in the simplified ASHMI formula for asthma.
• Qi and blood deficiency, weak digestion: poor appetite, listlessness, loose stools, fatigue, dizziness, soreness of lower back. Can be used alone.
• Antineoplastic activity: by enhancing immune function. Increases monocytes, macrophages, and T-lymphocytes. Increases production of tumor necrosis factor, interleukin, and interferon.
• Cardiovascular: increases cardiac contractility, lowers blood pressure, increases resistance of cardiac muscle to hypoxia.
• Antibiotic properties, broad spectrum, and inhibits E. coli, B. dysenteriae, Pseudomonas spp., pneumococci, streptococci (type A), staphylococci, and others.
• Hepatoprotective, antidiabetic, antitussive, expectorant, sedative, analgesic, and anti-asthmatic effects.
Hsu: Nourishes, supplements, tonifies, eliminates toxicity, astringes, disperses accumulation.
• For deficiency fatigue, neurasthenia, insomnia, bronchial cough in elderly, cancer.
SNBCJ: The six colors of Ling zhi are the first six herbs listed in the superior class section of the Shen Nong Ben Cao Jing. [only red and black are commonly available in the U.S.] The color of the mushroom indicates its flavor and affinities, based on five element correspondences.
• Of all varieties, the SNBCJ says, “Protracted taking may make the body light, prevent senility, and prolong life so as to make one immortal.”
Qing zhi (green/bluegreen) is sour and mainly affects the liver.
Huang zhi (yellow) is sweet and mainly affects the spleen.
Bai zhi (white) is acrid and mainly affects the Lungs.
• Purple also exists (Zi zhi), which is not associated with any single element.
Hei zhi (black) is salty and balanced. It mainly treats urinary dribbling block, it disinhibits the water passageways, boosts kidney Qi, frees the nine orifices, and sharpens the hearing
Chi zhi (red) [the most common form available, and the one which is used to calm the Shen] is bitter and balanced. It mainly treats binding in the chest, boosts the heart Qi, supplements the center, sharpens the wits, and [causes people] not to forget. Its other name is Dan zhi (Cinnabar Ganoderma).
GIRI: Enhances the immune system; contains carcinostatic component (β-(1-3)-D-Glucan); antitumor (interferon-inducing) activity; reduces blood pressure; lowers serum cholesterol; lowers serum glucose; inhibits platelet aggregation; treats hepatitis; promotes robustness.
• Historical reputation as a cancer cure.
• Appearance varies tremendously, based on culture conditions – six major colors, four major shapes.
• Once extremely rare. Now mass cultivated on bed logs or sawdust.
Amato: Anti-inflammatory. May reduce the inflammation which is a critical factor in Alzheimer’s and cardiovascular disease.
CHA: (Karen S Vaughan, 8-26-2000): The ganodermas (black G. lucidum, red G. lucidum, G. oregonense, G. tsuga, G. adspersum and G. applanatum) are tonic, immune strengthening, protect against cancer, have anti-tumor properties, calm the spirit, protect and clear heat from the central nervous system, open the heart, lower serum cholesterol and are good for adrenal fatigue and for depression and anxiety. They enter all five zang organs. They have anti-allergic effects, inhibiting histamine production and stabilizing immunoglobulin levels. They lower blood pressure, are antioxidant, antiviral and antibacterial. Combining with astragalus, atractylodes and Ren shen increase phagocytosis, promote immune globulin formation, promote lymphocyte transformation, and induce the generation of interferon. Chinese mountain climbers use Ling zhi to alleviate altitude sickness by oxygenating the blood.
I learned from a Thai doctor with a cancer practice, Santi Rosswong, to make a water decoction of Ganoderma lucidum (Ling zhi) with 10% cordyceps [Dong chong xia cao] for stamina. But since the polysaccharides in ganoderma are quite long, it has been shown to be more effective if the decoction is taken with not less than 500 mg of vitamin C, and 5 mg of folic acid each time. (The vitamin C is based upon Japanese research by Morishige and the folic acid is based upon Santi’s clinical experience.) Take several tablespoons (or more) every three hours. The most important dose is just before retiring, which should be larger. Take the folic acid and vitamin C with each dose.
There are two types of tinctures. One uses a concentrated decoction and adds alcohol to stabilize it. When I make it, I learned from Chris Hobbs to shoot for 25% alcohol to protect the polysaccharides, to ensure that I got between 22% and 28%, the lower number for spoilage and the upper number being a maximum for the polysaccharide protection. This appears to be the best formulation for immune system effects. The other way is to use a high alcohol formation to get the triperetenes, but I understand that this destroys the polysaccharides and differs significantly from the constituents extracted in traditional uses or from powdered extracts. It may have stronger CNS effects however. I know several herbalists who make a high alcohol tincture and add it to the subsequently decocted marc to get the best of both (and they understand that the high alcohol just makes the polysaccharides clump together but does not destroy them). There is not a consensus.
Ling zhi has various steroidal compounds, long chain polysaccharides, bitter triperetenes such as ganodermic acid and some volatile oils. Unlike Echinacea which activates macrophages, ganoderma is not believed to stimulate the immune system directly. It is probably an immune regulator rather than an immune stimulant. Ling zhi mushrooms get to the bone marrow and induce the marrow to put on more nucleated marrow cell mass, according to Jia. The marrow then increases B-cell production, which in turn increases antibodies. The DNA and RNA made in the bone marrow increases production of lymphocytes. This very deep immune nourishing means that it may be appropriate for AIDS patients although the patient should not suffer from undue dampness. For cancer therapy, combined with other fu zheng herbs, Ling zhi can be quite useful, even for patients undergoing chemo and radiation. Hobbs recommends low dose decocted ganoderma with cinnamon bark and orange peel as a tonic drink (for those not suffering from undue dampness) and I find that preparation, with roasted dandelion or chicory, combines well with coffee, helping neutralize coffee’s negative effects.
PLB: Some sources (including Subhuti Dharmananda of ITM) indicate that when ethanol is introduced to a water extract of Ling zhi (at greater than 25% by volume) the polysaccharides are not destroyed, but precipitated. Therefore, in a bottle of Ling zhi extract with over 25% ethanol, the polysaccharides are likely to be stuck to the sides of the bottle or settled at the bottom (or they are still stuck in the manufacturer’s vessels). When attempting to deliberately concentrate the polysaccharides, this is a useful phenomenon. Water extracts may be treated with up to 99% ethanol so polysaccharides – a greyish-white powder – can be claimed. For normal use, hot water extracts are best, and should be preserved with less than 25% ethanol (or as much glycerine as you like).
Weng Weiliang, et al.:

Effects on central nervous system
ling zhi preparation could reduce spontaneous activity of mice, strengthen the inhibitory effects of reserpine and chlorpromazine on nerve center, antagonize the excitatory function of benzedrine on nerve center, prolong the pentobarbital sodium induced sleep time, strengthen hypnogenesis effect of pentobarbital sodium at sub-threshold dose, antagonize electrical convulsion. Besides, it also had analgesic effect.
Effects on respiratory system
ling zhi had obvious antitussive effect, it could prolong the latent period of cough induced by ammonia stimulation, or decrease the times of cough significantly. chi zhi preparation had spasmolytic effect on smooth muscle contract of isolated trachea induced by histamine, and the effect was directly proportional to the medicine concentration.
Effects on cardiovascular system
ling zhi could significantly increase the cardiac contraction, decrease the heart rate in isolated toad heart, increase the contraction force of in situ rabbit heart. chi zhi liquid (3g/kg) could antagonize acute myocardial ischemia caused by hypophysin, significantly lower the high T wave in ECG.
Hot water extract of ling zhi could lower blood pressure, this effect was the most obvious 3 hours after oral administration. Initial clinic test also proved its blood pressure lowering effect and fat lowering effect. The blood pressure lowering effect of mycelin extracted from the mycelium of ling zhi had the characteristics of taking effect quickly, short action time, and dosage dependence.
ling zhi could also antagonize blood coagulation, prevent the thrombus formation, inhibit the platelet aggregation, and increase the deformability of aged RBC.
Effects of improving anoxia tolerance
chi zhi preparation could increase the anoxia tolerance of normal mice and mice pre-treated isoprenaline under lower pressure and normal pressure circumstance. Dried powder of fermented ling zhi could also increase the anoxia tolerance ability of mice, particularly the ability of cardiac muscle, and lower the oxygen consumption whole animal, improve the cardiac metabolism of anoxic animals.
Effects of lowering blood sugar
Ethanol extract of chi zhi had no influence over the increase of insulin secretion 10 minutes after oral administration of glucose, but had inhibitory effect on the continuous decrease of plasma insulin 30 minutes after the administration. It could also inhibit the increase of blood sugar induced by injection of adrenalin or oral administration of glucose. Polysaccharides of ganoderans A, B, C and heteroglycan isolated from ling zhi were injected intraperitoneally to mice at the dosage of 100mg/kg, the results showed that it could blood sugar.
Effects of protecting liver and detoxification
The increase of serum GPT and accumulation of liver triglyceride in mice induced by CCl4 injection could be obviously improved by oral administration of ethanol and ether extract of fruit body onload=”highlight();” of zi zhi and chi zhi. Besides, the extract could also relieve fatty liver caused by ethionine, promote the liver regeneration and strengthen the detoxifying function.
Immune hepatic injury was markedly induced by BCG or BCG plus inflammatory cytokines in BALB/c mice in vivo and in vitro. Under BCG-stimulated condition, augment of the liver weight and increase of the serum/supernatant ALT level were observed, as well as granuloma forming and inflammatory cells soakage were observed by microscopic analysis within liver tissues. Moreover, NO production was also increased by BCG or/and CM stimuli in the culture supernatant, and a lot of iNOS positive staining was observed in BCG-prestimulated hepatic sections. Application of Ganoderma lucidum polysaccharide (GLP)significantly mitigated hepatic tumefaction, decreased ALT enzyme release and NO production in serum/supernatant, improved the pathological changes of chronic and acute inflammation induced by BCG-stimuli in mice. Moreover, the immunohistochemical result showed that GLP inhibited iNOS protein expression in BCG-immune hepatic damage model. The study indicates that NO participates in immune liver injury induced by Mycobacterium bovis BCG infection. The mechanisms of protective roles by GLP for BCG-induced immune liver injury may be due to influence NO production in mice.
Effects on smooth muscle
chi zhi preparation could inhibit the smooth muscle activity of isolated rabbit intestines and isolated ileum of Guinea pig, and the effect increased with the increase of medicine concentration. Concentrated solution of fermented chi zhi could also obviously inhibit the contraction of isolated rat uterine.
Effects of immune regulation
Extract of mycelium of bo gai ling zhi could significantly promote the phagocytosis rate of celiac macrophages and activity of lysosome in mice, obviously inhibit DNA synthesis in lymphocytes and T and B lymphocyte transformation induced by ConA and bacillus coli endotoxin. ling zhi polysaccharide had certain immunoenhancing effect.
The polysaccharide component with a branched (1–>3)-beta-D-glucan moiety from G. lucidum (PS-G) has shown evidence of enhancement of immune responses and of eliciting anti-tumor effects. Annexin V staining and MTT assays reveal that PS-G is able to inhibit spontaneous and Fas-induced neutrophil apoptosis, and this effect of PS-G is enhanced by the presence of zVAD (a caspase inhibitor) and GM-CSF. The antiapoptotic effect of PS-G is diminished by the presence of wortmannin and LY294002 (two PI-3K inhibitors), but is not altered by PD98059 (a MEK inhibitor). Western blotting indicates the stimulating effect of PS-G on Akt phosphorylation and its inhibition of procaspase 3 degradation, which occurs in neutrophils undergoing spontaneous apoptosis or triggered death by Fas. Taken together, PS-G elicitation of antiapoptotic effects on neutrophils primarily relies on activation of Akt-regulated signaling pathways.
A fucose-containing glycoprotein fraction which stimulates spleen cell proliferation and cytokine expression has been identified from the water-soluble extract of Ganoderma lucidum. Proteomic analysis of mouse spleen cells treated with this glycoprotein fraction showed approximately 50% change of the proteome. Further studies on the activities of this glycoprotein fraction through selective proteolysis and glycosidic cleavage indicate that a fucose containing polysaccharide fraction is responsible for stimulating the expression of cytokines, especially IL-1, IL-2 and INF-gamma.
Anti-allergic effect
ling zhi could obviously inhibit the allergic reaction of Guinea pig passively sensitized by egg albumen antiserum, tetanus toxoid antiserum on antigen attack, it could also significantly inhibit the release of allergic mediators such as histamine and SRS-A by lung tissue of Guinea pig actively sensitized by egg albumen antiserum or tetanaus toxoid antiserum on antigen attack. This effect would strengthen with the increase the dosage of ling zhi.
Anti-tumor effect
Water decoction of ling zhi could inhibit the growth of tumor. Hot water extract of mycelia of artificially cultured chi zhi had inhibitory effect on the growth of fibrosarcoma and metastasized focus of lung. Ganodenic acid, a kind of triterpene isolated from chi zhi, had cell toxicant on cultured liver carcoma in vitro.
The triterpene-enriched fraction, WEES-G6, was prepared from mycelia of G. lucidum by sequential hot water extraction, removal of ethanol-insoluble polysaccharides and then gel-filtration chromatography. It’s found that WEES-G6 inhibited growth of human hepatoma Huh-7 cells, but not Chang liver cells, a normal human liver cell line. Treatment with WEES-G6 caused a rapid decrease in the activity of cell growth regulative protein, PKC, and the activation of JNK and p38 MAP kinases. The changes in these molecules resulted in a prolonged G2 cell cycle phase and strong growth inhibition. None of these effects were seen in the normal liver cells. This findings suggest that the triterpenes contained in G. lucidum are potential anticancer agents.
A study was designed to investigate the protective effect of a dietary water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi or Mannentake) mycelia (designated as MAK) on the induction and development of azoxymethane (AOM)-induced colon tumors in male F344/Du Crj rats. A total of 80 animals were divided into five groups at six weeks of age, groups 2, 3 and 4 being given weekly subcutaneous injections of AOM (15 mg/kg body onload=”highlight();” weight) for the initial 3 weeks to induce colon tumors. Rats in group 1 and 5 were injected with the vehicle, 0.9% (w/v) saline, following the same schedule. Rats in groups 1, 2, 3, 4 and 5 were fed MF, MF, 1.25% MAK, 2.5% MAK and 2.5% MAK diets, respectively, starting 1 week before AOM treatment and throughout the six-month experimental period. There were no significant differences in number of ACF, total AC and AC per site among groups 2 to 4, but the tumor incidence was significantly lower, and tumor size was smaller in group 4 (AOM + 2.5% MAK) than in group 2 (AOM + MF). Additionally, beta-catenin positive tumor cell nuclei were significantly decreased in the MAK-fed rats (groups 3 and 4), which also demonstrated lowering of the PCNA labeling index and a shortened germinal region in the colon. The present results thus indicate that dietary MAK could act as a potent chemopreventive agent for colon carcinogenesis.
Spores or dried fruiting body onload=”highlight();” of G. lucidum inhibit constitutively active transcription factors AP-1 and NF-kappaB in breast MDA-MB-231 and prostate PC-3 cancer cells. Furthermore, Ganoderma inhibition of expression of uPA and uPA receptor (uPAR), as well secretion of uPA, resulted in the suppression of the migration of MDA-MB-231 and PC-3 cells. The data suggest that spores and unpurified fruiting body onload=”highlight();” of G. lucidum inhibit invasion of breast and prostate cancer cells by a common mechanism and could have potential therapeutic use for cancer treatment.
Different concentrations of Ganoderma lucidum(Leyss ex Fr) Karst Compound(GLC) (from 4 mg/ml to 12 mg/ml) could promote human bone marrow granulocyte-macrophage colony forming unit (CFU-GM) proliferation, but suppressed the growth of K562 leukemic cell colonies, and IC50 was 9.2 mg/.ml. The data from liquid culture demonstrated that GLC could suppress K562 cells proliferation in a dose-dependent(from 4 mg.ml-1 to 20 mg.ml-1) and time-dependent(from 1-5 days) manner. K562 cells could be induced to differentiate into more mature erythrocytic cells by 4 mg/.ml and 8 mg/ml GLC. It is concluded that GLC may be a good medicine for leukemia therapy.
Anti-aging effect
Water extract of chi zhi could prolong the average life span of drosophilas, but it could neither lengthen the maximum life time, nor inhibit the brain MAO-B activity in mice.
Antiviral effect
To investigate antiherpetic substances from Ganoderma lucidum, various protein bound polysaccharides, GLhw, GLhw-01, GLhw-02, GLhw-03, were isolated by activity-guided isolation from water soluble substances of the carpophores. These substances were examined for their antiviral activities against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) by plaque reduction assay in vitro. Among them, the acidic protein bound polysaccharide, GLhw-02 of a brownish substance, exhibited the most potent antiherpetic activity with 50% effective concentrations (EC50) of 300 approximately 520 microg/ml in Vero and HEp-2 cells, and its selectivity indices (SI) were more than 20. GLhw-02 was identified to consist mainly of polysaccharide (approximately 40.6%) and protein (approximately 7.80%) by anthrone test and Lowry-Folin test, and showed the usual molar ratio (C:H:O = 1:2:1) of carbohydrates by elemental analysis. These results suggest that GLhw-02 possesses the possibility of being developed from a new antiherpetic agent.
A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 micrograms ml-1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM.
Mucosal healing effect
Fruiting bodies of Ganoderma lucidum (GLPS) at 250 and 500 mg/kg by intragastric input caused ulcer-healing effect in the rat; this was accompanied with a significant suppression of tumor necrosis factor (TNF)-alpha gene expression, but with an increased ornithine decarboxylase (ODC) activity. In RGM-1 cells, GLPS at 0.05, 0.25 and 1.0 mg/ml significantly enhanced [3H]thymidine incorporation and ODC activity in a concentration-dependent manner. However, these effects were abrogated by the addition of the ODC inhibitor, DL-alpha-difluoromethyl-ornithine (DFMO). GLPS at 0.25-1.0 mg/ml also increased mucus synthesis, as indicated by the increased D-[6-3H]glucosamine incorporation in RGM-1 cells. Furthermore, GLPS at 0.05-1.0 mg/ml increased the c-Myc protein expression. These findings indicated that GLPS produced a mucosal healing effect in the rat model, perhaps due partly to the suppression of TNF-alpha and induction of c-myc and ODC gene.
Antiperoxidative, antiinflammatory, and antimutagenic effects
The ethanol extract of the mycelium of Ganoderma lucidum occurring in south India showed significant inhibition of Fe2+-induced peroxidation of lipid in rat liver (IC(50) 510 +/- 22 micro g/ml) and 37% inhibition of croton oil-induced peroxidation on the mouse skin at 20 mg/0.1 ml/skin. Carrageenan-induced acute and formalin-induced chronic inflammatory edema were inhibited by 56 and 60%, respectively, by the extract at 1,000 mg/kg body onload=”highlight();” wt (i.p). The extract at a concentration of 5 mg/plate showed inhibition of mutagenicity elicited by direct acting mutagens, NaN(3) (55.5 and 75.7%) and MNNG (50.0 and 57.5%) for S. typhymurium strains TA100 and TA102, respectively. The extract at the same concentration also inhibited mutagenicity elicited by NPD (52.4 and 64.2%) and B[a]P (60.7 and 59.6%) for TA98 and TA100 strains, respectively. The B[a]P was activated in the presence of rat liver microsomal (S9) fraction. The results revealed that ethanol extract of Ganoderma lucidum mycelium possessed significant antiperoxidative, antiinflammatory, and antimutagenic activities. The findings suggest a medicinal use for the ethanol extract of the mycelium of G. lucidum occurring in South India.
Mice peritoneal macrophages were injured by reactive oxygen species (ROS), derived from tert-butylhydroperoxide (tBOOH). The survival rate of macrophages was measured by MTT assay, and the morphological changes of macrophages were observed under light and electron microscopes. It was found Ganoderma lucidum polysaccharides peptide (GLPP) (50, 100, 200 mg/kg, ip for 5 d) could inhibit the foam cell formation and necrosis of macrophages. The survival rate of macrophages was increased. GLPP (3.125, 12.5, 50, 200 mg/L) given to the cultured macrophages brought the same protective effects. Under the electron microscope it was found that GLPP (100 mg/kg, ip, for 5 d) could protect the organelle such as mitochondria against injury by tBOOH. The results indicated that GLPP had significant scavenging ROS and antioxidant effects.
Hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; this indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages.
The amino-polysaccharide fraction (designated as ‘G009’) from Ganoderma lucidum was tested for the ability to protect against oxidative damage induced by reactive oxygen species (ROS). G009 significantly inhibited iron-induced lipid peroxidation in rat brain homogenates and showed a dose-dependent inactivation of hydroxyl radicals and superoxide anions. It also reduced strand breakage in phiX174 supercoiled DNA caused by UV-induced photolysis of hydrogen peroxide and attenuated phorbol ester-induced generation of superoxide anions in differentiated human promyelocytic leukaemia (HL-60) cells. These findings suggest that G009 from Ganoderma lucidum possesses chemopreventive potential.
Hot-water extract of Ganoderma lucidum had good radioprotective ability, as well as protection against DNA damage induced by metal-catalyzed Fenton reactions and UV irradiation. Water-soluble polysaccharide isolated from the fruit body onload=”highlight();” of Ganoderma lucidum was as effective as the hot-water extract in protecting against hydroxyl radical-induced DNA strand breaks, indicating that the polysaccharide compound is associated with the protective properties.

• Coronary heart disease: ling zhi preparation had therapeutic effects on angina pectoris and increased blood fat in coronary heart disease to a certain degree, it could lower serum cholesterol, triglyceride and b-lipoprotein. 20% Ling Zhi Tincture, 10ml tid was used to treat 30 cases of angina pectoris for consecutive more than half a year, the results were 17 markedly effective, 18 effective, 4 ineffective.
• Arrhythmia: Ling Zhi Injection was used to treat 53 cases of various types of arrhythmia, the results showed that arrhythmia disappeared completely in 20 cases, 13 improved, 7 had a relapse, and 13 were ineffective.
• Chronic bronchitis: ling zhi preparation had quite good therapeutic effect on chronic bronthitis, but it took effect slowly, usually 1~2 week after administration. It also had good long-term therapeutic effect.
• Bronchial asthma: Infantile patients with bronchial asthma were treated with Ling Zhi Injection im 1~2 ml for consecutive 1 month. 27 cases were treated, and 9 were markedly effective, 14 effective, and 4 ineffective.
• Viral hepatitis: ling zhi preparation was used to treat hepatitis of various types, the total effective rates were 73.07%~97%, markedly effect rates were 44%~76.4%. Generally speaking, it had better effects on acute hepatitis than on chronic hepatitis.
• Leukopenia: Artificially cultured ling zhi was used to treat 52 cases of leukopenia caused by various reasons, the results: 11 cases were markedly effective, 12 effective, 21 improved, the near-term effective rate was 84.6%, the total number of WBC increased by 1088/mm3.
• Malignant hemopathy: Lao Jun Xian (ling zhi) Oral Liquid combining chemotherapy was used to treat 26 cases of malignant hemopathy, the total effect rate was 88.9%.
• Impotence: Sliced ling zhi, 6g per day, was decocted with water to get concentrated juice. The juice was taken when getting up early with empty stomach, or 1 hour before meals. 36 cases were treated, the total effective rate was 93.94%.
• Infantile idiopathic thrombocytopenic purpura: Ling Zhi Syrup (each ml contained 0.175g raw drug), 10~15mg, tid, a course of treatment consisted of 2 weeks ~ 2 months. 30 cases were treated, and 27 cases had an over half year follow-up survey, among them, 19 markedly effective, 3 effective, 1 improved, and 4 ineffective. The increase of platelet increase by more than 100,000/mm3 in 12 cases, 6~90,000/mm3 in 6 cases, 4~50,000/mm3 in 8 cases and 2~30,000/mm3 in 1 cases.

 

Dose: 1.5-15g or more (some say 15g is the minimum effective daily dose)

Suan Zao Ren – Zizyphus seed – Sour Jujube seed – “Sour Date Seed”

Nature: sweet, sour, neutral

Enters: Heart, Liver, Gallbladder, Spleen

Actions: Nourishes heart Yin and liver Yin/blood; quiets the Shen; astringes sweat.

Indications:
• Heart and liver blood or Yin deficiency: insomnia, palpitations.
• Liver Yin deficiency with Yang rising: irritability.
• Weak constitution: spontaneous or night sweats.
• Sedative, hypnotic.
• Tolerance develops (abates with a break).
• Lowers blood pressure.
Raw: stronger sedative; can clear heat and treat insomnia due to Yin deficiency heat. May make some patients too sleepy.
Dry-fried: more effective for spontaneous sweats.
• Often combined with Hou po (Suan zao ren:Hou po ::2:1), Chen pi, or other herbs to counteract its greasiness.
• Can be taken alone, 4g 1-2 hours before bed for insomnia.
• Should be ground, or at least broken, before use.
Hsu: Stimulates the uterus, caution in pregnancy; inhibits the CNS.
BII: Suan Zao Ren Tang is as effective as some benzodiazepenes for nervousness, anxiety.
DY: Nourishes heart Yin and blood; quiets the Hun and Shen; supplements the liver and gallbladder; treats heart palpitations due to gallbladder deficiency.
• With Bai zi ren for mutual reinforcement, to effectively nourish both the liver and the heart, tranquilize the heart, and quiet the spirit. For indications such as:
– 1. Palpitations, profuse dreams, and insomnia due to heart blood (and Qi) deficiency. (Tian Wang Bu Xin Dan) Defatted Bai zi ren and stir-fried Suan zao ren should be used.
– 2. Constipation with dry stools due to blood deficiency and intestinal fluid insufficiency.

Dose: 9-20g

Shou Wu Teng (Ye Jiao Teng) Polygonum multiflorum vine (aerial portion of He Shou Wu) – “Vine to Pass Through the Night”

Nature: sweet, slightly bitter, neutral

Enters: Heart, Liver

Actions: Nourishes the heart and blood; unblocks the channels; quiets the Shen; alleviates itching.

Indications:
• Yin or blood deficiency: insomnia, irritability, and especially dream-disturbed sleep
• Blood deficiency (with channel blockage): general weakness, soreness, pain, numbness.
• Topical: use as a wash for itching and rashes.
• I have found it unusually effective, even as a single herb, for insomnia.
MLT: Sore, aching, tired limbs from blood deficiency with internal wind.

Dose: 9-30g

Yuan Zhi – Polygala root – Chinese Senega – “Profound Will” or “Long-term Memory”

Nature: acrid, salty, slightly warm

Enters: Lung, Heart, maybe Kidney

Actions: Quiets the Shen; relieves mental stress; resolves phlegm; opens the orifices of the heart; disperses swelling; reduces abscesses; improves the memory; supports the Jing; disperses stagnant heart Qi, helps the heart and kidney communicate.

Indications:
• Insomnia, palpitations, disorientation, poor memory, mental stress, restlessness, especially with brooding or constrained, pent-up emotions.
• Blockage of orifices of the heart by phlegm: mental disorders, fuzzy- headedness, epilepsy, emotional and mental disorientation.
• Lung phlegm: cough with copious sputum, especially when difficult to expectorate.
• Carbuncles, boils, abscesses, sores, swollen and painful breasts: (uncommon use) – used in powdered form and applied topically or taken with wine.
• Stimulates animal uteri.
• Excessive amounts can cause nausea and vomiting.
• Caution with peptic ulcer, gastritis.
Li Shi Zhen: This herb reaches the kidneys, improves the memory, supports the Jing.
Li: Warm and drying – caution with Yin deficiency.
DY: Use honey-fried or licorice-processed to avoid irritation to gastric mucous membranes and nausea.
MLT: Similar to various Western species, including Western Senega Snake root.

Dose: 6-9g

Part Two Begins Here: Heavy Substances That Anchor the Shen

These substances are all minerals, with the exception of Hu Po (amber). Their “heavy” quality can be thought of through the doctrine of signatures as conferring an anchoring effect on the Shen. In the case of amber, although it’s not a mineral (instead, old, hardened sap), its qualities of being  old and very slow to form perhaps contribute to a similar quality.

These herbs are all somewhat difficult to digest and are minimally soluble in water. For this reason, it doesn’t exactly make sense to purchase them as granules. They are as potent as they can get in their raw form. Unlike a plant herb, where something can be extracted and potentiated, a decoction or granule is going to be much, much weaker than the raw substance. It’s like taking a 1 gram calcium tablet, boiling it in water, straining the liquid, and dumping out the calcium powder that’s at the bottom of the pan. How much do you think made it into the water? Just a fraction of what was in the pill. The only possible advantage to using any of these herbs as granules might be that they’re easier to digest than the raw powder, but this is only because they’re mostly starch and very little mineral. For much less money, you could have just used the raw powdered medicinal at a dose of something like 10-20% of what you would have used in granule form (you’ll have to figure out the actual math on this).

Ci Shi – Magnetite – (Oxides of Iron, also Magnesium and Aluminum) – “Magnetic Stone”

Nature: acrid, salty, cold

Enters: Heart, Liver, Kidney

Actions: Anchors and quiets the Shen; subdues liver Yang rising; nourishes the kidneys and liver; brightens the eyes and promotes hearing; brings Qi from Lung to the kidneys (aids the kidneys in grasping the Qi).

Indications:
• Hyperactive liver Yang due to liver Yin deficiency: restlessness, insomnia, palpitations, dizziness, headache, convulsions, tremors.
• Fear: convulsions in children.
• Liver/kidney Yin deficiency: blurry vision, tinnitus, poor hearing or deafness.
• Kidney Qi deficiency: asthma.
• Caution for long term use: probably contains heavy metals.
• Very difficult to digest.
• Be cautious of damage to the (anatomical) liver and heart.
• Usually prepared by being fired, dipped in vinegar, then pulverized.
• Generally cooked 20-30 minutes longer than other herbs.
DY: Should be systematically combined with Shen qu (which “enables the digestion of metals”) so it can be digested.
• With Shi chang pu to enrich the kidneys, calm the liver, diffuse impediment, open the portals, and sharpen the hearing. For indications such as:
– 1. Tinnitus and/or deafness due to Yin deficiency or deficiency fire. (Use vinegar dip-calcined Ci shi.)
– 2. Headaches, vertigo, heart palpitations, vexation and agitation, and insomnia due to Yin deficiency causing Yang hyperactivity. (Use unprepared Ci shi. However, it is important to know this form can cause abdominal pain. Therefore, the dosage should be moderate [15g] and it should be combined with Shen qu.)
Hsu: Inhibits the CNS; stimulates formation of blood cells (hemopoietic).

Dose: 9-30g (1-3g directly as powder)

Hu Po – Amber – Succinum

Nature: sweet, neutral

Enters: Heart, Liver, Bladder

Actions: Anchors and quiets the Shen; relieves convulsions, tremors, and palpitations; promotes blood circulation; dispels blood stasis; promotes urination; reduces swelling and promotes healing.

Indications:
• Shen disturbance: insomnia, palpitations, excessive dreams, forgetfulness, anxiety, seizures; also for childhood convulsions and seizures.
• Blood stasis: amenorrhea, pain from trauma, palpable immobile masses; coronary heart disease.
• Scanty, difficult urination or retention of urine, hematuria.
• Sores, carbuncles, ulcerations of the skin, swelling and pain around the scrotum or vulvular area.
• Generally not cooked.

Dose: 0.9-3g (directly as powder or pill)

SD: Not all amber is derived from pine resin, as other trees also release similar resins, but pines are considered a primary source. Pine resin contains a number of aromatic compounds: the terpenes, such as pinene, carene, sabinene, limonene, etc., which may be lost during the period of aging to become amber. There are also molecules that give the resin its sticky quality, such as those that make up the hardened pine resin product called colophonium (rosin), mainly abietic acid (image above) and pimaric acid.

These compounds found in pine resin are either pure hydrocarbon (pinene is an example of a pure hydrocarbon, containing only carbon and hydrogen), or hydrocarbons with small amounts of oxygen. There is very little of any other element in the resin (some resins may contain sulfur; a small amount of minerals might be present).

When the tree resin resides in the ground for millions of years, it hardens as moisture is lost and as some of the hydrocarbons cross-link (polymerize) to form longer chains. Pine resin has a relatively low cross-linking capability, so the process is slow and limited. The resulting amber is still chemically similar to the original resin, but it contains more of an essentially inert hydrocarbon mass, which is what gives it the hardness and glass-like nature that is appreciated when using amber for decorative items. Amber still contains some of the larger terpene molecules (4). In a single study of Baltic amber reported in 1877, but repeated by most modern authors, it was said to have 3-8% succinate (succinic acid), which is probably a derivative of the original simple terpenes.

MEDICINAL USES IN CHINA

Succinum is classified in China as being sweet in taste (though, in fact, it has barely any taste, being only slightly bitter and sweet; it has no fragrance), and neutral in nature. It is useless in decoction because so little material is extracted in boiling water (there is some extraction into alcoholic media). Mainly, Chinese amber is ground to powder and swallowed down with water or, more commonly, with a decoction of herbs that make up a formula with the succinum. It is also combined into pills made with powder or extract of the other ingredients. Typical dosing for succinum is 1.5-3.0 grams for one day. Because the powder is very fine, to avoid getting it stuck in the throat or inhaled, it is common to stir the powder into the warm decoction and swallow it down; being soaked in the liquid, the powder won’t cause any problems.

In the Materia Medica (5), succinum is listed among the “settling” or “heavy” sedatives, which are mainly mineral materials; in fact, amber is organic and quite light weight. There is an ancient saying in China that “when the tiger dies, its soul enters the earth and transforms into stone,” referring to the droplets of amber. So the material is called tiger’s soul: hupo (the po is the bodily soul; there are also spirit souls, called hun, that can roam about, but the po goes into the ground). Another sedative used by the Chinese is called fu-shen (spirit of poria), which is a segment of pine root with a solid fungus, poria (also called hoelen), that grows on it. In terms of sedative effects, fu-shen and amber are attributed similar properties. The properties of amber are also shared with other, chemically unrelated, fossil materials such as dragon bone and dragon teeth (mainly fossilized remains of mastodons and other large animals from the ice age period; they are mainly composed of calcium carbonate and other mineral components).

The calming effect of succinum is only one of the claimed properties, which include these main areas:

Subduing fright, tranquilizing the mind, and relieving convulsion. Succinum is used in the treatment of palpitation, amnesia, dreaminess, insomnia, epilepsy, etc. According to Jiao Shude (6), it is mainly used to treat epilepsy; this is typically first diagnosed during childhood, so amber is used in pediatric formulas. According to the traditional Chinese viewpoint (which differs markedly from the modern medical interpretation in this regard), epilepsy is caused by children becoming frightened when they see a strange sight or hear a strange sound. An example of a Chinese treatment for epilepsy in babies and young children is the ancient Hupo Zhenjing Wan (Amber Fright-Settling Pill), a formula of 25 ingredients (7), including minerals (pearl, cinnabar, realgar; the latter two are based on heavy metals), animal parts from endangered species (rhino horn, musk), as well as ordinary herbs (mentha, angelica, uncaria, etc.). A smaller version of this formula is called Hupo San (Amber Powder), with 14 ingredients, but including the cinnabar and musk, as well as other substances of concern; several of its ingredients must be swallowed as powder, the others made into tea. A more suitable formula incorporating amber for modern use is Hupo Duomei Wan (Amber Sleep-improving Pill), made with just five ingredients: amber, codonopsis, hoelen, licorice, and antelope horn (an endangered animal species, that can be substituted by their domestic water buffalo horn); this formula is not indicated for epilepsy, however.

Alleviating water retention and relieving stranguria (difficult urination). Succinum is applied to the urinary disorders such as stranguria complicated by hematuria (blood in the urine), particularly when caused by pathogenic heat. Succinum is considered to be like hoelen, with which it is often combined, in promoting urination through its bland nature. A formula for kidney and bladder stones, with blood in the urine, is called Hupo San (Amber Powder; different than the formula by the same name mentioned above), with amber, plantago seed, juncus, and mentha (the three herbs are made as tea, which is then used to swallow down the amber powder). A modern formula, produced in Taiwan (Kaiser Pharmaceuticals) and sold worldwide, is Hupo Huashi Pian (Amber Stone-Transforming Tablets), which is used for kidney and bladder stones with blood in the urine; the formula includes imperata and san-chi (notoginseng; also called tien-chi ginseng) for stopping or preventing bleeding, and diuretic herbs for promoting the passage of stones. Some of the ingredients of the tablet, such as desmodium, lygodium spore, and orthosiphon, are reputed to shrink stones. In a Chinese clinical report (8), a formula called Paishi Decoction was given to 215 patients with renal, urethra, or bladder stones every four hours, resulting in elimination of stones in nearly 60% of the patients. The formula included amber, dianthus, plantago seed, gardenia, lysimachia, gallus (jineijin), rehmannia, achyranthes, lygodium spore, phellodendron, akebia, and licorice. A similar formula (9), called Rongshi Decoction (replacing dianthus, rehmannia, and phellodendron with malva, talc, bamboo leaf, and rhubarb), was given twice daily to 32 patients with stones in the urinary system. This method required an average treatment time of 45 days, but it was claimed that 30 patients had passed their stones. A third formula of similar nature (10), called Hupo Shiwei Decoction, using pyrrosia, talc, lysimachia, and lygodium spore as the main diuretic herbs, and with several blood vitalizing herbs (e.g., red peony, sparganium, zedoaria, and vaccaria) to accompany the amber, was given three times daily to 51 patients having urolithiasis. It was reported that 35 were cured, and that stones were found in the urine of many of the patients, the largest stone passed was 1.6 x 0.8 cm. In the Chinese clinical work, patients were told to drink plenty of water and also to do jumping exercises to try and help move the stones down.

Promoting blood circulation to remove blood stasis. Succinum is used in the treatment of amenorrhea and abdominal mass caused by blood stasis and stagnation of vital energy. Amber is also recommended for lower abdominal pains affecting the genitalia, such as pain of the testes, prostate, uterus, or vulvar region. Amber is included in the 28-ingredient formula Da Tiaojing Wan (Major Menstruation-Regulating Pill) for irregular and painful menstruation (7). A clinical report (11) described a formula for benign prostate swelling, called Bushen Sanjie Decoction, derived from the traditional Rehmannia Eight Formula with addition of tonic herbs, such as codonopsis, astragalus, and asparagus, and blood vitalizing herbs, including amber, pangolin scale, eupolyphaga. It was claimed that following treatment for 6-12 months, 25 of the 30 patients so treated showed some improvement. Recently, amber has been included in some formulas for treatment of heart disease, because of its claimed blood vitalizing effects; for example, it was combined with ginseng and notoginseng in the treatment of angina (12). Yang Yifan (13) also mentions the use for heart disease, saying: “In clinical practice, it is used for patients with heart diseases when the blood is not circulating properly, and at the same time the patient has palpitations and restlessness, such as seen in coronary heart disease.” The same formula with amber, ginseng, and notoginseng has been prescribed in cases of chronic liver disease to normalize the blood conditions (14). Jiao Shude (6) mentions that amber “frees the orifices” which is designation for treating conditions such as atherosclerotic blockage of the arteries and blood clots that can cause angina, heart attack, and stroke.

Other internal uses: Amber is used as an ingredient in tonic formulas, often along with pearl powder. A qi and blood tonic formula for lowering blood lipids-Jianyanling-is comprised mainly of amber, astragalus, pearl, rehmannia, ho-shou-wu, polygonatum root, and American ginseng; in addition to lowering lipids, it is used as an anti-aging formulation and a treatment to aid recovery for cancer patients after undergoing standard medical therapies (15, 16). Succinum is used in treating stomach ache, also in formulas with pearl. An example is the formula designated Weibao; the basic formula is comprised of pearl and amber with alisma, indigo (qingdai), mume, bletilla, licorice, san-chi, and rhubarb. To this, various additions would be made according to the presenting signs. In the study report of 100 patients treated with the Weibao formulas for chronic gastritis, about 80% of patients were said to show significant improvement of symptoms when using the herbs for 3-6 months (17).

Topical applications: Astringing ulcers and promoting tissue regeneration. Used externally, it is efficacious in the treatment of ulcers, boils, swellings, etc.

Since this fossil resin has ingredients in common with those of the original resin, a look at other Chinese pine materials that contain the resin may shed light on the actions of amber. Aside from fu-shen (mentioned previously), there are two of them still used today (5):

Colophonium (pine resin; rosin; originally called songzhi = pine teeth, and now called songxiang = pine fragrance) is said to be sweet and warm, and having the properties of drying dampness and dispelling wind and wind-damp (e.g., treats rheumatism). It is mainly used topically.

Pine Nodes (songjie = pine node) is described as bitter and warm, having the properties of dispelling wind, drying dampness, and strengthening tendons and muscles. It is often used for “rheumatism.”

Further, if one examines other resins, such as “dragon’s blood” (xuejie), used in Chinese medicine, they are typically recommended for vitalizing blood and alleviating pain, and applied topically to heal wounds.

Long Gu – Fossilized Bone (usually mammal vertebrae and extremities) – “Dragon Bone”

Nature: sweet, astringent, slightly cold

Enters: Heart, Liver, Kidney

Actions: Anchors and quiets the Shen; subdues the liver; suppresses liver Yang rising; astringes and controls any body fluids.

Indications:
• Heart/shen agitation: insomnia, palpitations, epilepsy, depression, mania, anxiety.
• Liver Yang rising: dizziness, restlessness, irritability, easily angered, blurry vision, vertigo.
• Deficiency/weak body constitution: spermatorrhea, leukorrhea, uterine bleeding, night sweats, spontaneous sweating, vaginal discharge.
• Topical: powdered and calcined for non-healing carbuncles, furuncles, sores and ulcerations.
• Its sedative property is probably due, in part, to its richness in calcium.
• Drier than Mu li and stronger to settle the Shen, better for tremors.
• Often used with Mu li to harness rising Yang.
• Use Long gu raw to settle and calm the Shen.
• Use the calcined form as an astringent for preventing leakage of fluids and for non-healing sores.
• Cook 20-30 minutes longer than other herbs.
Hsu: Anti-inflammatory, expectorant, hemostatic, astringent.
DY: Quiets the Hun.

Dose: 15-30g

 
Long Chi: fossilized teeth
• Astringent, cool.
• Basically same as Long gu, but more sedating, and especially good for palpitations with anxiety, insomnia, and dream-disturbed sleep.

Dose: 9-15g

Sheng Tie Luo – Iron filings – “Raw Iron Leavings”

Nature: acrid, cool

Enters: Heart, Liver

Actions: Calms the liver; sedates the Shen.

Indications:
• Withdrawal-mania, delirium from febrile disease, palpitations, insomnia, being easily startled or prone to anger.
• Decoct for an extra 60-90 minutes.
• Note high doses of iron are toxic, particularly to children. Even in adults, excess iron may contribute to an increased risk of heart disease and colon cancer.

Dose: 9-30g

Zhu Sha – Cinnabar – Mercuric Sulfide – “Vermillion Sand”

Nature: sweet, cold, toxic

Enters: Heart

Actions: Anchors and quiets the Shen; clears heat and eliminates toxicity from the heart; sedates the heart; prevents putrefaction; expels phlegm and clears heat.

Indications:
• Shen disturbance / hyperactive fire in the heart: insomnia, hot sensation in the chest, palpitations, restlessness, anxiety, convulsions. Depending on the herbs with which it is combined, it can be used for treating patterns of heat excess, phlegm-heat, or blood deficiency.
• Heat and toxicity: carbuncles.
• Topical: mouth sores, sore throat, snake bite, carbuncles.
• Wind-phlegm dizziness and Lung heat
• Especially indicated in cases resulting from fright and anxiety.
• Antiseptic
• Use only the recommended dosage, take for a short time.
• Contraindicated in patients with a Western diagnosis of liver or kidney disease.
• To avoid mercury poisoning, DO NOT HEAT this herb.
Jin: Can substitute Hu po when Zhu sha is unavailable or inappropriate. [Or illegal]
Liu: Temporary use of appropriate dose when indicated is harmless.
Li: “[When overused] this herb makes people stupid.”

Dose: 0.3-2.7g (directly as powder or pill, or added to strained decoction)

Notes on This Category

• These herbs are to be used only for excess conditions (heat, toxicity, phlegm, etc.). They are forbidden for Yang or Qi collapse.
• These herbs are very acrid and have the potential to damage the Qi.
• Also consider: Niu huang, Zao jiao, Yu jin, Yuan zhi, herbs that resolve phlegm (Bai fu zi, Dan nan xing…)
• These herbs are commonly combined with:
A. Herbs that clear heat and eliminate toxicity when loss of consciousness is due to (Xue level) heat and toxicity.
B. Herbs that disperse cold and promote Qi circulation when loss of consciousness is due to cold phlegm (this is not common).

An Xi Xiang – Benzoin – (Resin of Styrax benzoin and other Styrax species) – “Peaceful Rest Fragrance”

Nature: acrid, bitter, neutral

Enters: Heart, Liver, Spleen

Actions: Opens the orifices; promotes Qi circulation; promotes blood circulation.

Indications:
• Delirium or coma with a stifling sensation and focal distention in the chest and abdomen.
• Qi and blood stagnation: pain in the chest and abdomen.
• Tinctures of the herb have been shown to directly stimulate the mucosa of the respiratory tract and promote expectoration.
• Difficult to procure in the U.S.
Hsu: Stimulates CNS; stimulating expectorant – when dissolved in hot water and inhaled, directly stimulates the mucosa of the respiratory tract, increases secretions, promotes discharge of phlegm.
• Inhaling too high a concentration can irritate the nose, eyes, and throat.
PCBMP: Antiseptic, expectorant, astringent.
• Topical: on wounds, ulcers (including of the mouth) to protect and disinfect.
• Inhale for coughs, bronchitis, colds.

Dose: 0.3-1.5g (in pills and powders)

Bing Pian – Borneol – (Natural form is extracted from Dryobalanops aromatica or Blumea balsamifera) – “Ice Slice”

Nature: acrid, bitter, slightly cold

Enters: Heart, Spleen, Lung

Actions: Clears heat; relieves pain; dissipates nodules and stagnant fire; alleviates itching; aromatically opens the orifices, revives the spirit.

Indications:
• Used topically (especially for heat) for eye, throat, skin, and mouth problems: toothache, sore throat, pain and swelling of the throat, mouth ulcers, carbuncles, eczema (with Qing dai, Shi gao, sesame oil), sores, scabies, neuralgia, photophobia, excessive tearing. Commonly used topically to regenerate flesh.
• Loss of consciousness and convulsions due to various causes, primarily heat and toxicity.
• Mildly stimulates the peripheral sensory nerves.
• Has a stimulatory effect on the higher centers of the brain.
• Similar in action to She xiang, but weaker.
• Never cook or expose to heat.
• Natural borneol is Mei pian. It is safe, most effective, but difficult to procure. Most borneol is synthetic and should probably not be taken internally, except perhaps in very small doses.
Hsu: Antibacterial, antifungal; stimulates CNS.
SD: The Chinese traditionally obtained their borneol (as an isolate) mainly from Dryobalanops aromatica and from Blumea balsamifera. The latter is used as the herb Ainaxiang (fragrant herb that looks like artemisia), which is rich in borneol and also contains limonene, camphor, and other terpenoid compounds. The extracted borneol (longnaoxiang; fragrant dragon’s brain; also known as bingpian [ice slice] referring to the appearance of the finished product) is considered to be suitable for abdominal and chest pains, intestinal parasites, phlegm congestion, and fevers. Blumea is in the same plant family (Labiatae) as capillaris, chrysanthemum, and saussurea, which also contain important terpenes.
Borneol and bornyl acetate are ingredients in the following herbal materials: cardamon, magnolia, nutmeg, turmeric, ginger, liquidambar, lindera, camphor oil. These herbs are all used in the treatment of pain syndromes.
Three forms of borneol were mentioned in the Bencao Gangmu: aifen (powdery borneol), the crude product aipian (the refined substance, now known as bingpian), and aiyu, a by-product of distillation. The material was obtained from Blumea grown in the southern part of China, primarily Hainan Island (near Canton), or from imported material (from Borneo in Indonesia) derived from Dryobalanops. Borneol was originally used as a carminative to reduce fevers and alleviate digestive distress. It was also said to inhibit worms. Another name given to borneol was longnaoxiang (dragon camphor fragrance), referring to its alchemical applications (the term “nao” also means brain).
Today borneol is classified as an agent for opening blocked orifices, and is described as pungent, bitter, and slightly cold. It is indicated for severe obstruction of the orifices (that may cause coma or convulsive diseases), for heat syndromes, and for pain. Although not often mentioned as useful for this purpose, borneol is a common addition to treatments for lung diseases in modern clinical practice. It is also applied topically (usually with other substances) for a wide range of conditions, mainly for swelling in the throat, mouth sores, ear infections, cervical erosion, psoriasis, boils, pain, and eye diseases.
Because the resin is strongly aromatic and, partly, because of its historically high price (which has been reduced in recent years, in part due to the availability of the synthetic version), the recommended dosage is quite small. Many herb guides list the internal dosage as 30 to 100 mg, taken in powders or pills (if added to a decoction, it will all evaporate). The Pharmacopeia of the PRC indicates 150 to 300 mg per day. It appears that Chinese Herbal Medicine: Materia Medica by Bensky and Gamble has an error in reporting of dosages, indicating 300 to 900 mg per day, a higher recommendation than virtually all other sources.
TOPICAL APPLICATIONS OF BORNEOL
Borneol is used in greater frequency for topical applications than for internal use. Those applications are numerous, but especially apply to injuries, burns, rheumatic pains, hemorrhoids, skin diseases, and ulcerations of the mouth, ear, eye, and nose. Borneol (or camphor) is almost always used in complex formulas, and typically comprises 1.6 to 8.5 percent of the total prescription. Because topical preparations are often difficult to make in convenient form on the spot, they are frequently used as patent remedies.
In the English-Chinese Encyclopedia of Practical Traditional Chinese Medicine, vol. 4, a recipe for treating purulent otitis media is:
borneol 20% , dragon bone 33%, alum 20%, kaempheria (camphor root) 27% , one pig gallbladder. The powdered materials are applied in the ear once per day. Kaempheria (shannai) is a relative of ginger that contains borneol and camphor. Traditionally, kaempheria is used topically for toothache and internally for warming the spleen and stomach to treat cold pain in the abdomen, vomiting, and diarrhea.
The Manual of Dermatology in Chinese Medicine provides the following examples of special preparations with borneol for application to the skin:
Luhui Binz Zhu Weifu Ji: 1 fresh aloe-vera leaf, 0.3-1.0 grams borneol, a pinch of pearl powder: mash the ingredients together and apply 1-2 times daily for herpes zoster sores.
Bing Shi Dan: 30g calcined gypsum powder, 0.6g borneol powder: combine and apply to herpes zoster pustules.
Di Yu Er Cang Hu Gao: 18g each of phellodendron, red atractylodes (cangzhu), and xanthium, 36g sanguisorba, 3g menthol, and 1.5g each of calomel and borneol: grind to powder, combine with petroleum jelly, and apply to skin 2-3 times daily for atopic dermatitis.
Dong Chuang You: combine 5g borneol and 15g camphor with 100g dried chili peppers: grind the borneol and camphor into powder and add to a hot water extract of chili pepper (steep peppers in hot water for 10 hours in closed container, string and then add alcohol to precipitate solids that are removed). Add glycerine and apply the ointment 3-4 times daily to the affected area (but not ulcerated lesions) for treating frostbite.
Qing Liang Fen: combine powdered talcum (120g), licorice (20g) and borneol (12g): sprinkle on affected area 3-5 times daily for treatment of sunburn causing erythema, wheals, or itching.
Dahuang Bingpian Fang: combine 100g rhubarb powder and 20g borneol in 250g table vinegar: let steep for 7 days; apply to affected sites 3 times daily for seborrheic dermatitis.
Dingxiang Bingpian San: combine 30g cloves with 6g borneol: grind to powder and apply to underarms 1-2 times daily to treat sweat odor.
TOXICITY
The California Health Department, Food and Drug Branch, has raised concerns about the safety of borneol in patent remedies. Guanxin Suhe Wan, because it is currently available in the form of small capsules, might be accidentally taken in some overdose, but it seems unlikely that anyone would consume several times the 3 capsule recommended amount.
For references purposes, borneol is included in the amount of either 1% or 2% in some of the Seven Forests herb formulas made available from ITM for prescription by practitioners. In 700 mg tablets, this corresponds to 7-14 mg of borneol per tablet. With daily dosing of 6-18 tablets (the upper dose being the highest recommended in the ITM literature and twice the highest amount suggested on the label), the amount of borneol taken in one day can range from 42 mg (6 tablets, 1%) to 252 mg (18 tablets, 2%). The amount of borneol is either below or within the range suggested by the Chinese Pharmacopoeia (100-300 mg), and corresponds well with recommendations in various Materia Medica guides (which have dosages as low as 30 mg). The Seven Forests formulas, used as examples of traditional-style prescriptions, have about the same concentration of borneol (1-2%) as does ordinary cardamon seed. Cardamon, including sharen and baidoukou, commonly used as a medicinal as well as food spice, typically contains 2-3% essential oil, for which borneol and camphor, as well as closely related chemical compounds, are the primary constituents.
The concern about borneol apparently stems from a worry about camphor oil.

Dose: 0.3-0.9g (taken directly)

She Xiang – Musk (Secretions from the Musk Deer)

Nature: acrid, warm

Enters: Heart, Spleen, Liver

Actions: Promotes blood circulation, relieves pain and swelling, dissipates clumps; intensely opens the orifices, revives the spirit, unblocks closed disorders; induces labor, hastens delivery, facilitates passage of stillborns.

Indications:
• Heart misted by phlegm or heat, heat entering the pericardium in warm-febrile disease, or other disorders which impair consciousness: loss of consciousness, coma, convulsions, delirium, fainting, stupor, closed disorders, tetanic collapse, phlegm collapse, seizures.
• Blood stasis: pain – acute chest and abdominal pain, Bi syndrome, trauma, toxic sores, carbuncles, immobile palpable masses, coronary artery disease, angina pectoris – comparable to nitroglycerine. For blood stasis disorders, it is used topically (in plasters, compresses) as well as internally.
• To discharge the placenta or fetus, combine with it with Rou gui.
• Powerfully anti-inflammatory.
• Thought to stimulate the CNS in small doses and inhibit it in large doses.
• Strongly stimulates the uterus; stimulates the heart.
• Possesses male hormone-like effects.
• Raises blood pressure.
• Musk deer are endangered and importation is illegal. Most commercially available musk is synthetic or is collected from raised deer.
• Due to its expense, this herb is never cooked.
• This is the most intensely aromatic and penetrating substance in the materia medica.
• Contraindicated in pregnancy and in cases of Yin deficiency heat.
• Helps other herbs cross the blood-brain barrier. Useful for brain conditions such as cancer and migraines.

Dose: 0.6-1.5g

Shi Chang Pu – Acorus rhizome (A. gramineus) – Related to and similar to the American species A. calamus (Calamus, Sweetflag)

Nature: acrid, warm

Enters: Heart, Stomach, Liver

Actions: Opens the orifices; calms the Shen; vaporizes phlegm; resolves damp; adjusts the stomach/harmonizes the middle Jiao; brightens the eyes; improves hearing; benefits muteness; mildly induces resuscitation.

Indications:
• Damp-phlegm obstruction of the heart and sensory orifices: fuzzy head, loss of consciousness, dizziness, forgetfulness, dull senses, seizures, stupor, phlegm blockage of the ears including deafness.
• Damp accumulation with Qi stagnation: chest, epigastric, and abdominal fullness and pain.
• Damp/phlegm in the middle Jiao which disturbs the mind.
• Used internally or externally for wind-cold-dampness: Bi syndrome, trauma, sores.
• Potential use in ADD/ADHD (e.g., Seven Forests Acorus Tablets).
• Increases digestive secretions, relaxes intestinal spasm.
• Ulcerations of the cornea: with Hu po, Gou qi zi, and Ju hua.
• Hoarseness with accompanying sputum in the throat or swollen, edematous vocal cords: with Jie geng and Shi hu.
• This herb’s ability to open the orifices is secondary to its general, aromatic action in vaporizing phlegm.
• Powdered herb can be blown up the nose in emergency situations.
• Used in Ayurveda to antidote marijuana.
• Contains beta-asarone, which has been show to be carcinogenic to animals in laboratory studies. These studies do not conclusively demonstrate any danger from standard therapeutic doses in humans. Also, beta-asarone is destroyed by prolonged cooking. Traditionally, Shi chang pu is long-cooked with other herbs. Beta-asarone has also been shown to be responsible for some of Acorus’s therapeutic effects. This study showed a benefit from beta-asarone in rats with Alzheimer’s disease. This in vitro study showed benefit against beta-amyloid (AD plaques) from a combination of beta-asarone and CBD.
DY: Some materia medica maintain that Shi chang pu opens the nine portals (the seven sensory orifices plus the anus and urethra). It is particularly effective for sensory or psychological problems such as deafness, tinnitus, nasal obstruction, blurred vision, loss of consciousness, slow-wittedness, loss of memory, dementia, and psychoses.
Shi chang pu is incompatible with meat, lamb’s blood, and Yi tang.
• With Chan tui to effectively rouse the spirit and open the portals. For vertigo, tinnitus, and deafness due to obstruction of the portals.
• With Ci shi to enrich the kidneys, calm the liver, diffuse impediment, open the portals, and sharpen the hearing. For indications such as:
– 1. Tinnitus and/or deafness due to Yin deficiency or deficiency fire. (Use vinegar dip-calcined Ci shi.)
– 2. Headaches, vertigo, heart palpitations, vexation and agitation, and insomnia due to Yin deficiency causing Yang hyperactivity. (Use unprepared Ci shi. However, it is important to know this form can cause abdominal pain. Therefore, the dosage should be moderate [15g] and it should be combined with Shen qu.)
Shi chang pu is a generic name which covers three distinct medicinal substances:
– 1. Jiu jie chang puAnemone altaica: Transforms phlegm; eliminates wind-phlegm; opens the orifices. To treat sensory or psychological disorders due to phlegm confounding the orifices of the heart, Jiu jie chang pu is the most appropriate and effective of these various medicinals.
– 2. Xian chang pu or Xi ye chang puAcorus gramineus var. pulsillus: Is prescribed fresh (Xian) and clears heat; transforms phlegm-heat; used for loss of consciousness due to febrile disease or accumulation of phlegm-fire.
– 3. Shi chang puAcorus gramineus: Transforms phlegm; eliminates dampness; stimulates hunger.
Bai chang pu or Shui chang puAcorus calamus [Sweetflag] is substituted for Shi chang pu by the majority of importers. This has a similar action to Shi chang pu, but is less powerful.
HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.
Hsu: Stimulates secretion of digestive juices, prevents abnormal fermentation in the GI tract; analgesic – relieves spasms of intestinal tract smooth muscle; sedative; antifungal; diuretic.
JTCM: For insomnia, particularly after history of using sleeping pills which have blocked the orifices of the heart with phlegm: use Wen Dan Tang plus Shi chang pu, Yuan zhi, He huan pi. In Ben Cao Gan Mu, Shi chang pu is said to tonify the heart Qi.
• Somnolence: when due to spleen Qi sinking, preventing the clear Yang from reaching the head, add Shi chang pu to Bu Zhong Yi Qi Tang. When due to phlegm-heat flaring up and blocking the orifices of the heart, add Shi chang pu to Huang Lian Wen Dan Tang.
• Fresh Shi chang pu juice can be dropped into the ear to unblock the ear and disperse EPIs.
• Tongue stiffness after wind-stroke.
• Hoarse voice, loss of voice, difficulty speaking: fresh herb gives better results than dry – use 15g fresh slices in tea (particularly effective with Chao yi, Xuan shen, Ma bo).
• Leukorrhea: in Ben Cao Gan Mu, it is said that Shi chang pu can treat uterine bleeding and leukorrhea. Use Hua Zhuo Tiao Jin Tang for dampness and imbalance of the Chong and Dai Mai: Shi chang pu 15g/day, Chao yi ren 30, Cang zhu 10, Bai zhu 10, Che qian zi 10, Chao huang qin 12.
• Inhibits growth of fungus. Especially good for women with both digestive disorders and leukorrhea.
• Short cook to preserve the volatile oil which calms the mind.
MLT: With Yu jin for mental derangement, the effects of intoxicating drugs such as marijuana, and lack of focus.
Yoga: Vacha, meaning “speaking” the power of the word, of intelligence or self-expression that this herb stimulates.
• Pungent, bitter, astringent/heating/pungent; V, K-; P+
• Stimulant, rejuvenative, expectorant, decongestant, nervine, antispasmodic, emetic.
• Colds, coughs, asthma, sinus headache, sinusitis, arthritis, epilepsy, shock, coma, memory loss, deafness, hysteria, neuralgia.
• Used by Vedic seers.
• Rejuvenates the brain and nervous system, purifies and revitalizes.
• Rejuvenates Vata and secondarily, Kapha.
• Clears the subtle channels of toxicity and obstructions.
• Promotes cerebral circulation, increases sensitivity, sharpens the memory, enhances awareness.
Sattvic nature.
• Helps transmute sexual energy, feeds Kundalini.
• Apply paste to the forehead for headaches, on joints for arthritis.
• Take nasally for congestion, polyps, to revitalize prana.
• Take with fresh ginger to counter its emetic properties.
• Take powder nasally to resuscitate from shock or coma.
• Caution with bleeding.
Weng Weiliang, et al:
• Epilepsy: shi chang pu extract was used to treat 90 cases of grand mal epilepsy and epileptiform discharge in EEG. Dosage for adult: 50mg, tid, 30 days as a course of treatment. In the clinical observation for 3 months ~ 2 years, the effective rate was 83.3%.
• Pulmonary encephalopathy: shi chang pu was made into injection. Mild pulmonaryencephalopathy was treated with intravenous injection of 10ml this injection mixed with 20ml 5% glucose, bid. For severe cases, the dosage was increased. 5~7 days as a course of treatment. 279 cases were treated, and the total effective rate was 74.89%.
• Coronary heart disease, pectoris angina: shi chang pu, xuan shen, chuan lian zi, long yan rou, sheng shan zha, chao mai ya, dang gui, long gu, mu li, chao zao ren, shu di, water decoction. 82 cases of pectoris angina due to coronary heart disease were treated, after days, 92.68% was relieved, and the EKG improving rate was 65.85%.
• Atrophic gastritis: dang shen, shi chang pu, e zhu, dang gui, pu gong ying, gan cao were used to treat 61 cases of atrophic gastritis, 27 cases were markedly effective, 14 effective.
RW: Aromatic bitter; powerful stomach tonic, encourages its secretions; stimulates the appetite for any type of anorexia.
• Chew the herb to help quit smoking.
• Tonic effect on the mucus membranes of the mouth and throat, and stimulates saliva.
• Put bits of the herb into a piece of cloth for a teething baby to chew on.
• Topical: the oil is refreshing and stimulating – for tired feet, varicose veins, more.
PCBMP: Chinese studies show the herb to be anti-arrhythmic, hypotensive, vasodilatory, anti-tussive, antibacterial, and expectorant.
• The American variety may be preferable to the Chinese kind, since it contains less or no β-asarone (a carcinogen) and is also more aromatic, with superior spasmolytic activity.
MW: Opens the sinuses (as in nasya oil) and third eye.
• Good for slow speaking, voice sounding impacted, or when the voice is wearing out, especially due to smoking or singing. Acts on the trachea.
• Post-stroke: inability to speak.
• Joint pain.
IBIS: (A. calamus)
• Qualities: aromatic, pungent, bitter, sweet, warm, dry.
• Affinities: mucous membranes.
• Actions: carminative, diaphoretic, sialogogue, spasmolytic, stomachic.
• Therapy: encourages secretory action of stomach; anorexia nervosa; lack of appetite in asthenic, young girls; children with umbilical colic; children with appetite disorders; tones mucous membrane lining mouth and throat; to stop smoking; teething children (Weiss, pp. 44-45); acute and chronic dyspepsia; gastritis; gastric ulcer; intestinal colic (British Herbal Pharmacopoeia, p. 14). Increases appetite, improves digestion.
• Use with caution during pregnancy due to emmenagogue effect (Lust, Farnsworth)
• Potential hallucinogen (Kinghorn; Lewis and Elvin-Lewis; Schultes and Hofmann, p. 201) [large dose of the fresh herb]
• Isolated constituents, beta-asarone and safrole, have been shown to be carcinogenic (Duke, pp. 14-15)
CHA: (Karen S Vaughan, 8-30-2001)
(Regarding the concern of beta-asarone carcinogenicity:)
Traditionally, in Mideastern and European herbalism, the Acorus calamus was candied, thus cooked for a long period, which would reduce the beta-asarone. Native Americans did chew the raw root as well as infuse and decoct it, but the dosage would tend to be self-limited as the taste can become unpleasant after prolonged chewing. (And I believe that the native American calamus species are somewhat milder.) However, in large doses sweet flag can be mildly hallucinogenic and quite emetic.
The Mongolians, who brought calamus to Russia in the 13th century, were known for planting the stronger Indian and Chinese versions of the root near water sources in order to keep the drinking water pure. It’s nickname “Mongolian Poison” appears to be a slur against the Mongols rather than a reference to the plant, which was considered benign. However, this tradition made more use of the antiseptic qualities of calamus.
The live plant was introduced into Europe in 1565 and widely distributed by the botanist Clausius. It was decocted for food stagnation, and for problems of the liver, gallbladder, kidney, bladder and for malaria. Leaves were burned as an aromatic disinfectant and insectide. The roots were burned to clear the air from typhus, cholera and influenza. It was used topically and in alcohol solution as a disinfectant, for scrofula and for ulcerous skin conditions.
In Ayurveda, Acorus calamus is known as Vacha and is generally used as a dried powder. This probably leads to a partial dispersion of the essential oils. It is considered light and drying and is frequently used for epilepsy and as a gargle for acute tonsilitis. It can be boiled with milk to reduce the mucous-producing properties of the milk. It is also used to counteract the effects of constant marijuana smoking.
One note which may account for the California ban: sweet flag oil is widely used as an aromatic wine adulturant.
The FDA frowns upon the sale and use of calamus and has issued directives to certain herb dealers not to sell it to the public. (An FDA directive is simply a polite word for a threat of hassling without a law to back it.) At present there are no federal laws against calamus.

Dose: 3-9g (up to 15g)

Notes on This Category

These herbs each possess any of four major actions:
1. Clear Liver Heat.
2. Subdue Liver Yang.
3. Extinguish Liver Wind.
4. Calm/Anchor the Shen.
These herbs are commonly combined with:
A. Herbs that clear heat or reduce fire from the liver when there is liver heat leading to Yang rising or liver wind.
B. Liver and kidney Yin tonics when liver wind is due to Yin deficiency of the liver and kidneys.
C. Herbs that quiet the Shen when there is Shen disturbance.
D. Herbs that resolve phlegm when liver wind stirs up phlegm and blocks the channels and collaterals.

Bai Ji Li (Ci Ji Li) – Tribulus fruit – Puncture vine – Caltrop – Tribulus terrestris

Nature: bitter, acrid, neutral

Enters: Liver, Lung

Actions: Subdues the liver, anchors the yang; frees the flow of liver Qi; eliminates external wind, dispels wind-heat; promotes vision; stops itching.

Indications:
• Liver yang rising: headache, dizziness, vertigo, hypertension.
• Liver Qi stagnation: distention in the chest, costal region, and flanks, postpartum galactostasis or insufficient lactation.
• Wind: skin eruption with itching, hives, vitiligo.
• Wind-heat: red, swollen, painful eyes, increased tearing; nasal congestion.
• Promotes urination.
• Lowers blood pressure.
• Recent Western use as “herbal Viagra” to improve libido and erectility.
• Guohui Liu: Useful for Liver attacking transversely, causing bloating, etc. (15-30g)
Yoga: Gokshura: sweet, bitter/cooling/sweet; VPK=
• Diuretic, lithotriptic, tonic, rejuvenative, aphrodisiac, nervine, analgesic.
• Cools and soothes the membranes of the urinary tract; stops bleeding.
• Rejuvenative to Pitta, calms Vata. Invigorating for postpartum women.
• Difficult or painful urination, edema, kidney or bladder stones, chronic cystitis, nephritis, hematuria, gout, rheumatism, lumbago, sciatica, impotence, infertility, seminal debility, venereal disease, cough, dyspnea, hemorrhoids, diabetes.
Hsu: Hypotensive, sedative.
DY: Upbearing and dispersing; calms the liver, resolves depression.
• With Sha yuan zi to regulate upbearing and downbearing and the liver and kidneys. Together, they course the liver and rectify Qi, resolve depression and calm the liver. They harmoniously supplement the liver and kidneys – they enrich the kidneys and secure the essence, nourish the liver and brighten the eyes. For such indications as:
– 1. Vertigo, unclear vision due to liver and kidney deficiency. (Use salt mix-fried Bai ji li – this alleviates the draining and dispersing characteristics of the herb and reinforces its supplementing aspect.)
– 2. Lumbar pain, seminal emission, premature ejaculation, frequent urination due to kidney deficiency. (Use salt mix-fried or stir-fried Sha yuan zi.)
– 3. Abnormal vaginal discharge due to kidney deficiency.
Examine.com’s literature review concluded: “Tribulus Terrestris is a herb commonly sold as an aphrodisiac, sexual performance enhancer, and testosterone booster. Currently, it seems that it does have scientific grounds to claim it is an aphrodisiac and perhaps high doses could be seen as a sexual performance enhancer.
“Science on Tribulus and testosterone is mixed and trending towards being ineffective. Currently three human studies have been conducted on the matter and found no fluctuations in testosterone with doses between 200-450mg Tribulus daily for up to 8 weeks. Higher doses in rats that correlate to 750mg in humans routinely find testosterone increases in castrated rats, and a single study exists to suggest that this testosterone boost at the same high dose can apply to normal rats.
“Beyond those claims, Tribulus is claimed to be a heart healthy compound and a large dose (3g) has been demonstrated to reduce blood pressure over the course of 4 weeks, with noticeable improvement at one week, in persons with hypertension.”

 

Dose: 6-12g

Dai Zhe Shi – Hematite – “Red Stone from Dai County”

Nature: bitter, cold

Enters: Liver, Heart, Pericardium

Actions: Subdues the liver, suppresses liver Yang rising; clears liver heat; descends the Qi of the Lungs and stomach, strongly directs rebellious Qi downward; cools the blood; stops bleeding; anchors the Shen.

Indications:
• Stomach Qi rebellion: belching, hiccups, vomiting. Use when Ban xia is not enough. This herb is not appropriate for morning sickness of pregnancy.
• Failure of Lung Qi to descend: wheezing, asthma.
• Liver Yang rising, liver fire: headache, dizziness, tinnitus, pressure around the eyes.
• Hematemesis, epistaxis. Primarily for bleeding due to heat, but can also be used for bleeding due to cold from deficiency when combined with appropriate herbs.
• Should be boiled for approximately 30 minutes before adding other herbs.
• Often calcined or pulverized after soaking in vinegar.
• Major known constituents include diferric trioxide, aluminum, silicon, magnesium, tin.
• Bensky/Gamble classifies this with herbs that anchor the Shen.
MLT: For short term use only – likely contains traces of arsenic.

Dose: 9-30g

Di Long – Earthworm – Lumbricus – “Earth Dragon”

Nature: salty, cold

Enters: Liver, Spleen, Bladder, Lung

Actions: Removes obstructions from the channels and collaterals; relieves asthma, calms wheezing; clears heat; extinguishes liver wind; stops spasms and convulsions; promotes urination.

Indications:
• Lung heat obstruction: asthma, wheezing. Clears Lung heat.
• Liver wind: convulsions with high fever, seizures – can be used alone.
• Damp-heat: Bi syndrome with red, painful, swollen joints.
• Obstruction of channels and collaterals: hemiplegia, sequelae of wind-stroke, for either hot or cold (with appropriate combination) Bi.
• Bladder heat: painful urination or retention of urine, cystitis, urinary stones, edema.
• Liver Yang rising: hypertension. Lowers blood pressure. Over 90% effective for essential hypertension in one study.
• Hot, manic type schizophrenia. (Recent use)
• Temporarily lowers men’s sperm count.
• May temporarily lengthen the penis.
• May inhibit the effects of histamine on smooth muscle.
• This herb’s effectiveness is enhanced by washing it in wine.
• This herb’s ability to treat spasms and convulsions (compared to Ling yang jiao and Gou teng) focuses mainly on its ability to open up and penetrate.
• Doctrine of signatures: earthworms’ (and other insects’) ability to remove obstructions is indicated by their skill at wriggling through small places or plowing right through the earth.
• Contains the fibrinolytic enzyme lumbrokinase. May have benefit in cardiovascular disease. One study showed “Oral lumbrokinase improves regional myocardial perfusion in patients with stable angina.”
• A very safe herb.
MLT: Insects [and worms] represent the essence of pure neurological instinct reaction that is akin to the manifestation of involuntary reflexes such as spasms, shaking, and stroke. Described as “strange proteins,” they seem to have a corrective effect on the nervous system. Customarily administered as a powder in capsules.
Hsu: Antipyretic, hypotensive (probably by direct action on CNS), bronchodilator, stimulates the uterus, small intestine and large intestine.

Dose: 5-15g

Gou Teng – Uncaria stem and thorns – Uncaria rhynchophylla, U. sinensis, and related species – “Hook Vine”

Nature: sweet, slightly cold

Enters: Liver, Pericardium, Heart

Actions: Clears liver heat; subdues liver yang; extinguishes liver wind, alleviates spasms; releases the exterior.

Indications:
• Liver wind: convulsions, tremors, seizures, eclampsia. Especially useful when due to intense heat.
• Liver heat: distention and pain in the head, red eyes.
• Liver Yang rising (including Yin deficiency patterns): dizziness, vertigo, irritability, blurry vision.
• Wind-heat: fever, headache.
• Lowers blood pressure. For hypertension take 30g twice a day. Especially useful when due to liver Yang rising. If there is liver Yin deficiency, combine with Bai shao – 2:1::Gou Teng:Bai Shao (i.e. 15g Bai shao BID). Gou teng’s hypotensive effect diminishes if it is cooked too long. Old stems, without thorns, have no hypotensive effect.
• Similar to Ling yang jiao, but while antelope horn enters the blood level, Gou teng enters the Qi level and is especially useful for problems secondary to externally-contracted wind-heat.
• Do not cook longer than 10 minutes.
• It is traditionally believed that the more hooks and less stems, the stronger the herb.
• Contains rhynchophylline – a non-competitive NMDA receptor antagonist (anesthetic) and calcium channel blocker.
Hsu: Hypotensive – inhibits vasomotor center, dilates peripheral blood vessels; sedative, inhibits the CNS; prevents epilepsy; antiviral – especially against respiratory viruses.
From “Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity.”:
• RESULTS: Rhynchophylline was the main constituent of several components identified from Uncaria species. Rhynchophylline mainly acts on cardiovascular and central nervous system diseases, including hypertension, bradycardia, arrhythmia, sedation, vascular dementia, epileptic seizures, drug addiction, and cerebral ischemia. Rhynchophylline also has effects on anticoagulation, inhibits vascular smooth muscle cell proliferation, and has been shown to be anti-endotoxemic. The active mechanisms are related to modulation of calcium and potassium ion channels, protection of neural and neuroglial cells, and regulation of central neurotransmitter transport and metabolism. More studies are necessary to verify the pharmacological activities and determine the exact mechanisms of rhynchophylline activity.
• CONCLUSIONS: Rhynchophylline treatment of cardiovascular and central nervous system diseases has a strong linkage with traditional concepts and uses of Uncaria species in ethnopharmacological medicine, such as treatment for lightheadedness, convulsions, numbness, and hypertension. As a candidate drug for several cardiovascular and central nervous system diseases, rhynchophylline will attract scientists to pursue the potential pharmacological effects and mechanisms with new technologies. Relatively few clinically relevant studies of rhynchophylline have been conducted. Thus, more in vivo validations and investigations of antihypertensive and neuroprotective mechanisms of rhynchophylline are necessary.

Dose: 6-15g

 

 

On the related herb Cat’s Claw / Una de Gato – Uncaria tomentosa:
This species grows much larger than the Chinese forms. The bark is used.
Its similarity (or lack thereof) to Gou teng has not been clearly established.
Major claims are that it is an immune enhancer, antiviral/antibiotic, anti-inflammatory, antispasmodic. Extracts (under the trade name Samento or Saventaro) are commonly used to treat Lyme disease. Shown in studies to fight the progression of Alzheimer’s disease (better when combined with Ginkgo leaf and Gotu Kola).
Recently, there has been some controversy over the constituents TOA’s (tetracyclic oxindole alkaloids) and POA’s (pentacyclic oxindole alkaloids). Numerous sources claim TOA’s are ineffective or even harmful, while the medicinal potency of the plant comes from the POA’s. Consequently, there are products which claim to be TOA-free and/or which maximize POA’s.
SD: Cat’s claw is one of several dozen herbs being promoted these days as an effective treatment, even a potential cure, for cancer, AIDS, chronic fatigue syndrome, candida infection, arthritis, and other disorders for which modern medicine is often unsatisfactory. The broad spectrum of action claimed for these herbs is not an impossibility, as the disorders that are said to be treated involve the immune system: there could be a central regulatory mechanism affected by a natural compound that leads to improvements for many patients with various diseases. The suggestion that the herbs produce dramatic effects or are curative rather than merely helpful is more problematic, as clinical evaluations of several such materials have failed to confirm many of the claims that were based on individual case studies.
Cat’s claw seems exotic because it is a native Indian remedy from the mountains of Peru. Yet, there is no evidence that it is any more valuable than less exotic items from China, India, Europe, or the U.S. which were previously considered exotic. Apparently, the root bark of the plant has been used by the aborigines in the area where it grows for gastric distress, skin diseases, arthralgia, and cancer. It is not clear how accurately cancer was diagnosed (in most medical traditions, cancers, abscesses, and non-malignant swellings were lumped together), nor what effect this herb had in native hands, nor whether it was only one of several remedies provided in combination to the patient. The “claw” which characterizes this vine may have been selected by “doctrine of signatures” as something that could penetrate and puncture a lump or grab the cause of localized pain. In China, the related plant Uncaria rhynchophylla (gouteng), is said by native healers to effectively treat headaches: the hook on the vine indicates that it can go in and grasp the pain to pull it out. This explanation may also come after the observation of effects, as an aid to memory: Chinese research confirms that the herb can treat certain types of headache, especially that associated with hypertension.
The active components of cat’s claw are mainly alkaloids, glycosides (triterpenes and procyanidins), and tannins. The oxindole alkaloids of the stem (including the hooks) are the same as those found in the Chinese plant that is far more intensively analyzed. Rhynchophylline, the main alkaloid, has been made into a drug in China for treating hypertension and headache due to vascular constriction. The alkaloids in the root bark of cats’ claw are in the same category as rhynchophylline, but are slightly differently. The claim made by some investigators appears to be that these unique alkaloids are responsible for the ability of the plant to treat cancer and to inhibit viral infections. Enhancement of phagocytosis in vitro was reported in 1985 by Wagner, a European researcher who has focused efforts on revealing immune-enhancing actions of natural products (his work with echinacea, eleutherococcus, and the liver-protective herb sylibum is frequently reported in the alternative medicine literature). However, it is not clear that sufficient amounts of such alkaloids are consumed so that one would obtain this effect nor how strong the effect might be. Based on his research experience, Wagner believes that polysaccharides, terpenoids, alkaloids, and polyphenolic compounds from plants have immunostimulating activity.
The triterpenoids of cat’s claw have been shown to have an anti-inflammatory effect. This effect is not surprising: dozens of plants with triterpenoids have an anti-inflammatory action; triterpenoid compounds often have a steroidal structure. Other materials have been isolated from the herb, such as oleanolic acid (which has anti-allergy actions), but the amounts are so small as to make their presence insignificant in relation to the herbal activity in clinical practice. Clearly, one can find numerous compounds in this plant and attribute healthful activities based on in vitro tests that require large amounts of the compounds, but that doesn’t mean one is likely to obtain those effects from oral consumption of recommended amounts (e.g., 20 grams by decoction or infusion, much less by ingestion of encapsulated powders) of the crude herb.
In a patent application for use of cat’s claw alkaloids for immune-modulatory effects against cancer, other alkaloids with similar effects obtained from other plants are mentioned, such as berbamine and matrine, ingredients identified from common Chinese herbs (e.g., hu-chang and sophora) that boost certain immune responses and which can be used in the treatment of cancer (Chang and But 1987). The question that arises is this: is it worthwhile collecting a species that has a limited growing range for which the root bark may be the key ingredient, and which is quite expensive, rather than using readily available plants that are less expensive and are already cultivated and which have far more supporting research for the intended application? The patent application also lists more than a dozen phenols/quinones and terpenes as examples of natural substances “with stimulating effect on the immunological system.”
That aside, one can examine carefully the research to date. In one study (Aquino, et al. 1991), anti-inflammatory compounds were isolated. In rat paw inflammation experiments (usually used in the study of potential anti-arthritis remedies), dosages of 2 g/kg of the dried bark (corresponds to typical human dosage of 140 grams of the herb) were used, and the most active isolated fractions were able to inhibit the rat paw edema by about 40%. Aspirin is a lot easier to use and more effective and although aspirin may cause gastric irritation, so might the isolated components of cat’s claw. The common, cultivated Chinese herb tang-kuei, has an anti-inflammatory action that is slightly greater than that of aspirin, weight for weight.
Antiviral activity of quinovic acid glycosides from cat’s claw were also analyzed (Aquino, Simone, and Pizza, 1989). As the authors of the study report: “an inhibitory effect against VSV [vesicular stomatitis virus] was evident for all the nine compounds tested, although at relatively high concentrations with respect to the toxic dose….” In other words, the antiviral activity was weak unless you approach the point where the herbal components would kill the cells as well. Before one reaches cell killing by a compound, severe side effects would tend to be observed clinically. The authors continue: “almost all these quinovic acid glycosides were inactive against rhinovirus type IB infection….” These same authors mention in their introduction the antiviral action of glycyrrhizin (from licorice). This and other components from readily-available and inexpensive herbs have been demonstrated effective in treating viral infections; for example, glycyrrhizin can cure a portion of clinical cases of chronic hepatitis B infection and it has been shown, in vitro, to inhibit HIV.
The potential antitumor activity of cat’s claw remains pure speculation. In a paper about the constituents of various Uncaria species in Peru, it was suggested (de Matta, et al.) that catechin in the root bark may be responsible for the effect. Catechin is believed to be anticarcinogenic, but it is obtained from dozens of other herbs (it is often found in barks) that are much more easily obtained (rhubarb is the main source used in Chinese anticancer studies). In a recent evaluation of antimutagenic effects (Rizzi, et al., 1992), it was speculated that cat’s claw acts as an antioxidant, thus potentially reducing the incidence of transformation to cancer cells via an oxidation reaction. Yet, there are dozens of antioxidants already identified which have this property, many of which have useful nutritional benefits (e.g., vitamins C and E, selenium, cysteine) and which are inexpensive and readily available. While these are thought to be useful in reducing cancer risk, their impact on existing cancers is minor.
To get around the rather poor outcomes found in laboratory experiments and the availability of alternative sources for materials for which similar claims could be made, promoters of cat’s claw resort to hyperbole. Philip Steinberg, a nutritional consultant, proclaims it a “wondrous herb from the Peruvian Rainforest,” and refers to an article by a chiropractor, Brent Davis, who proclaims it a “world class herb.” The patent issued more than five years ago is trotted out as primary evidence of its value. Indeed, cat’s claw has been sold in Europe, but an analysis of the capsules of product show that it is extremely low in the supposed active components compared to reference samples from Peru (Stuppner, Sturm, and Konwalinka, 1992) so that any claims made for it are likely placebo effects.
To promote the product, “The Cat’s Claw Quarterly” was generated. As illustration of its irresponsible reporting, the 10 page first issue carries not one author’s name. Keplinger, the holder of the above-mentioned patent is reported to have been treating AIDS patients in Europe. He proclaims benefits were observed as follows: “within twenty days treatment there were positive signs in the immune system.” Anyone working with AIDS knows that the manifestations of the disease is highly variable and that few, if any, patients stick to only one remedy at any time; besides that, there was no way to show “positive signs” in the immune system within twenty days back then (in 1987, two years before this first issue of the newsletter). An herbal correspondence course devotes lesson 26 to cat’s claw, as part of the larger section on “killing cancer.” All that is offered is a rambling narrative of the author’s attempt to track down information on cat’s claw (one section is headed “very little written about cat’s claw”). As an example of successful use of the herb for cancer, here is one story he relates from Austria, where Keplinger works: Male 14-year-old [with lymph leukemia]. Chemotherapy was applied. However, patient suffered extreme discomfort. Cat’s claw given. Three week’s later, blood values improved. Patient more active. Since the blood condition improved so much, they thought this was because of the chemotherapy. So they increased the dosage of chemotherapy. The blood test did not reveal further pathology. The patient is now considered a mostly healthy child.” That certainly shows that cat’s claw is effective against cancer by the contorted reasoning methods employed by such writers. Chemotherapy, which is effective in many cases of childhood leukemia, by this reasoning came out poorly in this report. In a letter to Townsend Letter for Doctors (an informal and unreviewed magazine), Steinberg claims that one Peruvian physician spoke at an international congress on traditional medicine “about his and his colleagues’ successes with Uncaria tomentosa and other herbs in treating 14 types of accurately diagnosed cancer in 700 patients.” The suggestion to be taken by the unsuspecting reader is that it was this herb that was responsible for the undefined successes. One wonders what these physicians actually did and what was actually said about the results.
Cat’s claw may indeed be a good remedy for gastritis (one wouldn’t be able to determine that from the current literature, however: gastritis isn’t as interesting as cancer and AIDS). Herbal therapies for gastritis are relatively easy for native herbalists to select, because the effects are usually prompt. There are hundreds of other gastritis remedies available; its just a matter of whether or not the gastritis sufferer will try them. If the first they try is cat’s claw, it may well be one they can say works for them.
At this time, there is no evidence that cat’s claw has significant immunological properties. It may have such properties, but there are potential problems with promoting it for this application. First, it appears that the tops of the plant, which mainly contain rhyncophylline in the stem and tannins in the leaves, are probably not effective for this purpose. In China, where immune regulators are a central area of concern, Uncaria species are not counted among them. When purchasing powdered materials, it is difficult to know if one is getting the right species (importers already caution that you buy their species of cat’s claw and not an alternative one, Uncaria guaianensis, available on the Peruvian market), much less the right plant part. If the root bark, which may have relatively unique compounds, is to be used, then the plants must be dug up, and we have one more case of damage to the rain forest plants. It has been suggested that the upper bark might have the same activity as the root bark, and it is possible, with vines, to collect the tops and still have the plant grow back. However, a careful analysis of the vine bark must be made and one must be assured of getting just this part (there isn’t much bark on this plant). But, why bother? There are so many established immune-regulating herbs already available that putting great effort into this one seems unappealing.
What about the current research status? In the U.S., this is being trusted to practitioners of natural medicine untrained or poorly trained in clinical evaluations who are to report on the effects in their patients (who are almost certainly taking other remedies at the same time) under the general heading of conducting a “clinical trial.” These practitioners will no doubt claim benefits seen in numerous patients, as they have in the past for each remedy that has been brought out for informal evaluation by practitioners untrained in research methodology. In Austria, Dr. Keplinger is said to be using a medicine extracted from the vine along with AZT in AIDS patients. His results (from the past eight years of experience) are being reported not in medical journals but in newspapers, such as El Comercio (Lima). In Peru, researchers are making a sincere effort to analyze the ingredients and effects of the plant. As reported in journals, the observed effects have been quite limited and the activities can be explained by compounds and mechanisms that do not require one use cat’s claw. Yet, an American distributor says that “Cat’s claw promises to become a major therapeutic agent worldwide in the very near future due to its unusual and significant health-stimulating properties.”
It is quite unfortunate that the diligent efforts of Peruvian researchers are being largely ignored in favor of the outlandish claims of chiropractors, nutritional consultants, and writers of informal correspondence courses. Desperate AIDS and cancer patients, as well as others, may be taken in by this (that is, after all, what the effort is all about), and spend their limited resources on this potentially endangered rain forest remedy when better-studied, more effective, and less expensive remedies are available to them. This is the ongoing problem with alternative medicine: uncritical acceptance of remedies promoted by persons with limited knowledge, but strong financial interests, and unreliable enthusiasm. If cat’s claw is a legitimate contributor to treatment of serious illnesses, then let the scientific knowledge be compiled and analyzed and then compared to what is known about other plant remedies before it is touted as the newest remedy for cancer and AIDS.
Appendix: Other Uncaria Species
Uncaria vines are native to Japan, China, Vietnam, and the Malaysian peninsula. Among the species used in China, interchangeably, are U. rhyncophylla, U. macrophylla, U. hirsuta, U. sessifructus, U. formosana, and U. scandens. The branch and stem are used for their nerve-inhibiting actions, associated with the alkaloid components. They are thus applied as a sedative, anticonvulsant, hypotensive, and analgesic. In Vietnam, U. tonkinensis is used; the bark of the vine is considered useful in lowering fever; it is said that the bark contains no alkaloids, but does contain catechin and catechutannic acid. In Malaysia, Uncaria gambir is used. The top of the plant is rich in tannins and is not very suitable for internal use (except temporarily to treat dysentery). Rather, it is applied topically for its antiseptic action (attributable to tannins) and some analgesic effects (probably due to the alkaloids). The roots are considered a remedy for intestinal inflammation, which is a common application of tannins. Such compounds may also have a positive effect on gastritis and urethritis, conditions for which cat’s claw has been claimed to be of use.

Jiang Can – (Bai Jiang Can) – Silkworm (Bombyx) infected with Beauveria bassiana

Nature: salty, acrid, neutral

Enters: Liver, Lung

Actions: Eliminates external wind, eases itching and relieves pain; extinguishes liver wind, relieves spasms and convulsions; resolves phlegm, dissipates nodules; clears heat, dissipates stagnant heat.

Indications:
• Wind: skin eruption with itching.
• Liver wind or wind-phlegm-heat: convulsions, facial paralysis, deviation of the mouth and eyes in wind-stroke, seizures.
• Liver heat or attack of the liver channel by wind-heat: headache, red eyes, sore, swollen throat, loss of voice.
• Stagnant heat: carbuncles, sore throat, toothache.
• Phlegm accumulation: lumps, scrofula, nodules.
• Use raw for dispersing wind-heat, otherwise dry fry.
• Compared to Wu gong and Quan xie in the treatment of wind and spasms, Jiang can is most appropriate for those due to phlegm-heat.
• Pound before cooking.
Hsu: Hypnotic, antispasmodic, stimulates adrenal cortex.
Dose: 3-9g (0.9-1.5g as powder or pill)

Jue Ming Zi – Cassia seed – Fetid Cassia seed – “Seeds of Realized Brightness”

Nature: sweet, bitter, slightly cold

Enters: Liver, Large Intestine, Kidney

Actions: Clears liver heat; expels wind-heat; promotes vision; moistens the large intestine, promotes bowel movement.

Indications:
• Liver heat or liver channel wind-heat: red, swollen, itchy, painful eyes with photophobia and increased tearing. Especially useful when liver heat is accompanied by constipation.
• Heat or dryness in the large intestine (especially from liver Yin deficiency): constipation.
• Used to prevent atherosclerosis: lowers blood pressure and serum cholesterol.
• Hypercholesterolemia: in one study of 100 patients (mean value 246.9 mg%, and as high as 484) given Jue ming zi decoction, 85% had normal values within 2 weeks. 98% were normal within 4 weeks. However, the value of total serum cholesterol as a measure of morbidity/mortality is questionable.
• Can counteract the constipating effects of some other herbs in this category (such as Mu li).
• Compared to Ju hua, Jue ming zi is better at clearing liver fire and benefiting the kidneys; Ju hua more effectively pacifies the liver and disperses wind-heat.
• Dry fried: tonifies the liver and is used for eye problems due to liver and kidney deficiency.
• Antibiotic effect.
• Bensky/Gamble classifies with herbs that drain fire.
• Bensky/Gamble: Do not use with Huo ma ren; not recommended when there is diarrhea or hypotension.
MLT: Pan roast and powder, and use as a coffee substitute for hypertension.

Dose: 9-15g (up to 30g alone)

Ling Yang Jiao – Antelope Horn

Nature: salty, cold

Enters: Liver, Heart

Actions: Clears liver heat; subdues liver yang (remarkably); extinguishes liver wind; promotes vision; clears heat and toxicity; clears damp-heat; quiets the Shen.

Indications:
• Liver wind: convulsions, spasms – infant, epilepsy, other seizure disorders, including for recalcitrant fevers, internal wind due to intense heat.
• Liver Yang rising: dizziness, vertigo, headache, blurry vision, red eyes, photophobia, hypertension, spasms, convulsions.
• Liver fire: red eyes, headache.
• Heart blockage by heat and toxicity with liver wind stirring: high fever, unconsciousness, delirium, involuntary limb movement.
• Wind-damp-heat: Bi syndrome.
• Doctrine of signatures: Antelopes and mountain goats live (and thrive) at high altitudes. The herb is useful for Yang that rises, like the peak of a mountain, and also for mountain sickness – increases resistance to a low oxygen environment.
• Less effective than Xi jiao (rhinoceros horn) at clearing heat and toxicity, but more effective at relieving spasms and extinguishing wind. The two horns are used together in severe cases of coma and convulsions due to high fever (however, rhinoceros horn should no longer be used, given rhinos’ endangerment).
• Take directly as powder or pills.
• Ling yang jiao is similar to Gou teng, but while Gou teng enters mainly the Qi level, Ling yang jiao enters the blood level, relives toxicity, and treats heat in the blood
Hsu: Antipyretic, anticonvulsive – tranqulizing, antispasmodic – inhibits CNS.

Dose: 0.9-3g (directly)

 
Shan Yang Jiao: Mountain Goat horn
• For ecological considerations, this herb may be used in place of Ling yang jiao.
• Mountain goat horn is much weaker – use 10 times the dose of antelope horn that would be used.

Dose: 9-60g

Mu Li – Oyster Shell

Nature: salty, astringent, slightly cold

Enters: Liver, Heart, Kidney

Actions: Subdues the liver and suppresses rising liver yang; anchors the Shen; benefits the Yin and anchors floating Yang; softens and disperses hardness, nodules, stagnation of phlegm and fire; astringes and controls body fluids; neutralizes acid (calcined form) and alleviates (stomach) pain.

Indications:
• Liver yang rising (including with Yin deficiency): restlessness, insomnia, palpitations, dizziness, vertigo, tinnitus, bad temper, red, flushed face
• stagnation of phlegm and fire: masses, lumps, swollen lymph nodes and glands, scrofula, goiter.
• Weak constitution (deficiency only – steaming bone disorder or following a warm febrile disease): seminal emission, leukorrhea, uterine bleeding, spontaneous or night sweats.
• Acidity: heartburn, excessive stomach pain with sour taste (Bensky/Gamble recommends the calcined form for this, while Liu says to swallow 10g uncooked, non-calcined Mu li). Note: Mu li contains a high amount of calcium carbonate. The carbonate acts as a pH buffer in the stomach, but calcium is a stimulus for acid secretion in the stomach (because it is soluble only at a low pH). At best, Mu li is a branch treatment for acidity. As antacids go, Mu li – and all antacids which contain calcium – may be inferior to those comprised of other mineral carbonates (such as sodium bicarbonate – baking soda).
• Muscle cramps: by “softening hardness” – anecdotally useful as a standalone herb, even in the common form of oyster shell calcium pills. Also beneficial for restless legs.
• Useful in treating night sweats due to tuberculosis.
• Weaker than Long gu to quiet the Shen, but stronger than Long gu to subdue liver Yang.
• “Slipperier” than Long gu.
• For astringing body fluids, use the calcined form, Duan mu li. For all other purposes use the unprepared form (note Bensky/Gamble says to use the calcined form for neutralizing acid).
• Cook for 20-30 minutes longer than other herbs.
• Bensky/Gamble classifies with herbs that anchor the Shen.
• Some sources claim Mu li works synergistically with Bei mu, Gan cao, Niu xi, and Yuan zhi, and that it has adverse effects when combined with Ma huang, Wu zhu yu, and Xi xin.
• The nacre in oyster shells is composed primarily of calcium carbonate in a crystal form known as aragonite.
Hsu: Astringent, sedative, analgesic, antioncotic.
• Use 90-120g for neck lymphadenitis.
DY: With Huang qi to supplement Qi, constrain Yin, secure the exterior, and stop perspiration. For indications such as:
– 1. Spontaneous perspiration due to Qi or Yang deficiency. (Mu Li San) Use calcined Mu li.
– 2. Night sweats due to Yin deficiency. (This combination is appropriate for moderate Yin deficiency. In cases of deficiency fire, this pair cannot be used alone.)
– 3. Spontaneous and nighttime perspiration due to Qi and Yin deficiency. (Mu Li San) Use calcined Mu li.

Dose: 15-30g

Quan Xie – Scorpion – Buthus

Nature: acrid, salty, neutral, toxic

Enters: Liver

Actions: Extinguishes liver wind, relieves convulsions; eliminates external wind; cleans and dissipates stagnation of (fire) toxicity, dissipates nodules; removes obstruction from channels and collaterals, relieves pain.

Indications:
• Liver wind, wind-phlegm: convulsions (acute or chronic infant), tetany, tics, deviation of the mouth and eye in wind-stroke, tremors, opisthotonos, seizures. This herbs is among the most effective at eliminating wind.
• External wind: convulsions due to tetanus (wind invades wound).
• Stagnation of toxicity: carbuncles, lumps, toxic sores, swellings – includes topical use – follows the theory “use toxin to attack toxin.”
• Obstruction of channels and collaterals (blood stasis): stubborn headaches, migraines, Bi syndrome.
• Lowers blood pressure; tranquilizer.
• Weaker anticonvulsive effect than Wu gong. Compared to Wu gong and Jiang can in the treatment of wind and spasms, Quan xie is most appropriate when there is heat.
• Start with a very low dose and slowly raise it (if necessary).
• Often combined with Wu gong.
• Contraindicated for internal wind due to blood deficiency; pregnancy.
LL: Essential for a serious headache – always consider this herb.
MLT: For cancer/tumors: powder Quan Xie with Wu gong and Jiang can, suspend in water in a cloth bag while cooking an egg in the water. Eat the egg and drink the broth.
Hsu: Antispasmodic (weaker than Wu gong), antifungal, sedative.

Dose: 2-5g or 0.9-1.5 of just the tail (0.6-0.9g directly as a powder)

Shi Jue Ming – Abalone shell – Haliotis – “Stone Sense Brightness”

Nature: salty, cold

Enters: Liver, Kidney

Actions: Clears liver heat; subdues the liver and suppresses rising liver yang; promotes vision, dispels superficial visual obstruction.

Indications:
• Liver yang rising: dizziness, vertigo, headache, hypertension.
• Liver fire: red and swollen eyes, nebulas, blurry vision, optic neuritis, photophobia, pterygium.
• Topical ophthalmic: apply as a very fine powder to eyes.
• If the digestion is poor, use only 15g.
• Decoct for about one hour longer than other herbs.

Dose: 9-30g

Tian Ma – Gastrodia rhizome – “Heavenly Hemp”

Nature: sweet, neutral

Enters: Liver

Actions: Subdues the liver and suppresses liver Yang rising; extinguishes liver wind, relieves convulsions; eliminates wind-damp; relieves pain.

Indications:
• Wind-phlegm or liver Yang rising: dizziness, also headaches, migraines. This is perhaps the best herb for dizziness in the pharmacopeia.
• Liver wind: convulsions, trembling, epilepsy, tonic-clonic spasms, opisthotonos, tetany, wind-stroke – including with hemiplegia, dizziness, and numbness of the extremities.
• Wind-damp: Bi, pain and numbness of the lower back and extremities.
• High doses can cause nausea and vomiting.
• Since this herb is expensive, some deceitful sellers in China will steam potatoes to shrink them and then sell them as Tian ma.
• Some advise against using this herb in cases of Yin deficiency (such as liver wind due to liver Yin deficiency), claiming that it is warm and dry, however, MLT says: similar to Gou teng, but its sweet flavor gives it Yin tonic properties.
Hsu: Anticonvulsive, cholagogue.
SD: Gastrodia refers to the tuber of an orchid, Gastrodia elata. This plant has an unusual requirement for survival: it must have the Armillaria mellea mushroom mycelia incorporated into the tuber in order to maintain its maturation and growth, and it requires another fungus, Mycena osmundicola, to sprout the seeds. When supplies of the crude gastrodia became rare in the 1970’s, attempts at cultivating the herb repeatedly failed until this complex synergistic plant/mushroom relationship was determined. Then, cultivation became easy, though it was not until the late 1980’s that an adequate cultivated supply of gastrodia was developed.
Interestingly, the medicinal benefits of gastrodia were found to be mainly the metabolites of the Armillaria mushroom. In other words, if one could grow the mushroom, the gastrodia tuber could be dispensed with and one could use just the mushroom material in place of gastrodia. This mushroom cultivation (by batch fermentation) was accomplished and the material was tested in the 1970’s; today, gastrodia mushroom (Armillaria) is frequently used instead of cultivated gastrodia. In the meantime, wild gastrodia, along with all other wild orchids, has been put on the endangered species list.
Gastrodia was listed in the ancient Shennong Bencao Jing (ca. 100 A.D.) and was later classified by Tao Hong as a superior herb, meaning that it could be taken for a long time to protect the health and prolong life (as well as treating illnesses). It was originally called chiqian, meaning red arrow, because of its red stem shaped like an arrow. Later it was named tianma, or heavenly hemp (ma, usually translated as hemp, refers to many plants that have fibrous stems, such as the well-known mahuang).
The traditional use of gastrodia is to calm internal wind and dispel invading wind, and invigorate circulation in the meridians; thereby treating headache, dizziness, vertigo, convulsions, paralysis, and arthralgia. In the book Chinese English Manual of Commonly-Used Herbs in Traditional Chinese Medicine, the three basic indications are reduced to this elaborated pair:
1. Calm the liver wind: For syndrome of liver-wind stirring inside, such as infantile convulsion, tetanus, epilepsy, as well as dizziness and headache due to excess of liver yang or the attack of wind-phlegm; recently it is also used for treatment of neurasthenia, nervous headache, and hypertension;
2. Expel wind evil and alleviate pain: For migraine, arthralgia due to wind-dampness, numbness of extremities, and general fatigue.
According to research reports, the main active ingredients include gastrodin, a complex glycoside, plus vanillyl alcohol and vanillin, which, as their names suggest, are related to the flavor vanilla (vanilla comes from the fruit of another orchid, Vanilla planifolia, and the primary flavor is vanillin, which is synthetically produced as the standard flavor substitute). Vanillin has been shown to have anticonvulsive effects. There have been numerous other compounds identified in both Armillaria and the gastrodia tuber, with roles that are not yet established.
The gastrodia mushroom, Armillaria (also listed as Armillariella), is known in China as tianma mihuanjun.
Like many other medicinal mushrooms, Armillaria contains immune-enhancing polysaccharides, but the amount of the gastrodia mushroom usually ingested is not sufficient to provide a substantial immune-enhancing action. Gram for gram, the armillaria mushroom is more potent than the gastrodia tuber, mainly because it is the primary source of the active constituents. An exact quantitative comparison has not been determined, and may vary with the different therapeutic applications, but, generally speaking, the dosage of armillaria to be used is about half that of gastrodia tuber. Because these products are safe to use, armillaria can be used in the same amount as the gastrodia rhizome it
replaces in order to attain superior effects.
Gastrodia tuber is traditionally given in decoction in doses of 3.0–10.0 grams per day; the gastrodia mushroom (fermentation product) or gastrodia tuber is given in the form of a powder in doses of 1.0–1.5 each time, 2–3 times per day (total dosage of 2.0–4.5 grams/day).
According to Icones of Medicinal Fungi, Armillaria fermentation products “are found to produce satisfactory effect in treatment of dizziness caused by hypertension, insufficient blood supply to the arteries’ cone base, Meniere’s syndrome, as well as functional disorders in autonomic nervous system. They are also effective in improving numbed limbs, insomnia, tinnitus, epilepsy, vascular headache, and apoplectic sequela [post-stroke syndrome].”
The Advanced Textbook on Traditional Chinese Medicine and Pharmacology mentions that “This herb is mild, and can subdue hyperactive liver yang, eliminate wind, and remove obstruction in the collaterals, and is indicated for all kinds of wind syndromes, either cold or heat type or due to internal or external wind. For such cases, it is combined with other herbs according to the specific conditions. It is an important herb to treat dizziness.”
Examples of combining gastrodia with other herbs include these, from the Textbook:
¨ For dizziness and headache due to hyperactive liver yang, combine with uncaria and haliotis.
¨ For upward disturbance of wind-phlegm, combine with pinellia and atractylodes.
¨ For migraine, combine with cnidium.
¨ For convulsion due to irritation by liver wind, combine with antelope horn and uncaria.
¨ For tetanus [tonic convulsion, a wind-phlegm disorder due to external wind] combine with arisaema and siler.
¨ To relieve wind and remove obstruction in the collaterals [luo vessels], producing rheumatic pain and numbness
of the limbs, combine with chin-chiu, chiang-huo, and achyranthes.

Dose: 3-10g (0.9-1.5g directly as powder)

Wu Gong – Centipede – Scolopendra

Nature: acrid, warm, toxic

Enters: Liver

Actions: Extinguishes liver wind, relieves convulsions; eliminates external wind; cleans and dissipates stagnation of toxicity; removes obstruction from channels and collaterals, relives pain, dissipates nodules.

Indications:
• Wind, tetanus: acute or chronic infant convulsions, opisthotonos, spasms, seizures, lockjaw.
Stagnation of toxicity: carbuncles, lumps, nodules, neck lumps, sores, poisonous snake bites, stings. Used internally and topically.
• Blood stasis, obstruction of channels: stubborn headaches, migraines, Bi syndrome, impotence. Directs herbs to the penis.
• Very effective at treating diphtheria (used with Gan cao in study).
• Antifungal.
• Possesses anti-tumor effects (in vitro).
• Effective for submandibular lymphadenitis.
• Some sources say to remove the legs and head – only use the trunk and tail.
• May cause stomach upset.
• Often combined with Quan xie.
• Stronger than Quan xie and Jiang can for wind and spasms. Since it is warm, is most appropriate for wind-cold. It is superior to the other two in the topical treatment of toxic swellings.
• Doctrine of signatures: Its form indicates its ability to direct to the penis and treat impotence. Liu: “Like an arrow that directs herbs to the penis.” Bugs, in general, are adept at squirming into small places, and are useful for opening blockages and freeing the channels.
• Usually taken directly in powder form (often in capsules).
• Contraindicated in pregnancy.
Hsu: Antibacterial, hypotensive, antispasmodic.

Dose: 0.9-3g (0.6-1g as powder or pill)

Zhen Zhu – Pearl – Margarita

Nature: sweet, salty, cold

Enters: Liver, Heart

Actions: Anchors the Shen; clears liver heat; eliminates superficial visual obstructions; sedates the heart; settles tremors, convulsions, and palpitations; astringes, promotes tissue regeneration; enhances the skin.

Indications:
• Shen disturbance or liver wind: palpitations, childhood convulsions, seizures.
• Disharmony of heart and Shen: easily frightened or angered.
• Liver heat: red, swollen eyes, nebulas, pterygium, blurred vision.
• Skin: take 1-2g internally daily to enhance skin.
• Topical: for non-healing ulcers, macerated areas (usually throat or gums); applied to the eyes as a very fine powder or in eye drops for nebulas; applies to the skin to soften, refine, and enhance its color.
• Often cooked with tofu and water for two hours prior to being ground into powder.
• Bensky/gamble classifies with herbs that anchor the Shen.
Hsu: Antihistamine, anti-allergic, diuretic.

Dose: 0.3-1g usually directly as powder/pill

Notes on This Category

These herbs promote proper circulation and dispel stasis for the recovery of normal blood circulation. According to Guohui Liu, with normal use, they will not move blood in an aberrant manner (with a few possible exceptions). Most of the herbs in the category are not anticoagulants.

Commonly combined with:
A. Herbs that warm the interior and disperse cold when blood stagnation is caused by cold obstruction.
B. Herbs that clear heat and cool the blood when blood stasis is due to congealing of the blood by heat.
C. Herbs that eliminate wind, cold, and damp when the channels are obstructed by invasion of these factors.
D. Qi tonics when Qi is deficient, and also to protect the Qi from damage by these herbs.
E. Blood tonics when blood is deficient, and also to protect the blood from damage by these herbs.
F. Herbs that resolve phlegm when blood stasis is caused by phlegm.

Other Herbs that Promote Proper Blood Circulation, to Consider When Appropriate:
An Xi Xiang [Open Orifices], Bie Jia [Nourish Yin], Chi Shao [Cool Blood], Da Huang [Promote BM], Dang Gui [Nourish Blood], Du Huo [Dispel Wind-Damp], Fu Zi [Warm Interior], Gu Sui Bu [Tonify Yang], Gui Zhi [Acrid, Warm], He Huan Pi [Calm Shen], Hong Teng [Clear Heat & Toxicity], Jing Jie Tan (charred) [Acrid, Warm], Lu Jiao [Tonify Yang], Mu Dan Pi [Cool Blood], Mu Tong [Drain Damp], Pu Huang [Stop Bleeding], Qian Cao Gen [Stop Bleeding], San Qi [Stop Bleeding], She Xiang [Open Orifices], Wa Leng Zi [Topical Herbs], Xie Bai [Move Qi], Xu Duan [Tonify Yang], Xue Yu Tan [Stop Bleeding], Xue Jia [Topical Herbs], Zao Jiao Ci [Resolve Phlegm], Zi Cao [Cool Blood].

Chuan Shan Jia – Pangolin scales – “Penetrate Mountain Scales”

Pangolins are remarkable creatures and they are endangered. Attempts to raise them in captivity have failed.

Like certain other (usually animal-derived) Chinese medicines, their legendary status is inflated. Furthermore, the market is flooded with plastic fakes.

No one needs pangolin scales in order to get well. Any trained herbalist can create an effective formula using other blood movers instead. If you buy this product, you fuel the demand for more. Stop using pangolin scales. 

I provide the following information just for historical reference, and to understand, if you ever encounter Chuan Shan Jia in a prescription, what the intended action is, so that you can choose a suitable alternative. 

 

Nature: salty, slightly cold

Enters: Liver, Stomach

Actions: Promotes blood circulation and dispels blood stasis from the channels; promotes lactation; relieves swelling; drains pus; unblocks menstruation; expels wind-dampness from the channels.

Historical Indications:
• Blood stasis: amenorrhea, masses, Bi syndrome, early stage carbuncles/boils or with pus that does not drain, lumps, dysmenorrhea. Alternatives to consider: Hong hua, Chi shao, Chuan xiong, Mu dan pi, Yi mu cao, Dan shen, Tao ren, Wang bu liu xing, Wu ling zhi, Tu bie chong, etc.
• Galactostasis after childbirth. Alternatives to consider: Pu gong ying, Wang bu liu xing, Si gua luo, Mu tong, etc.
• Toxic swellings: abscesses, boils. Can dissolve as yet unformed pus, but it is more useful for suppurative lesions. Can be used topically. Alternatives to consider: Zi hua di ding, Lian qiao, Tian hua fen, Chi xiao dou, Niu bang zi, Zao jiao, Chi shao, Mu dan pi, Xuan shen, Zhi zi, Tu fu ling, etc.
• Wind-damp obstruction of channels: pain, stiffness or spasms in the limbs, pain that prevents bending and stretching. Alternatives: see herbs that expel wind-dampness (Wei ling xian, Xi xian cao, Hai tong feng, Qin jiao, Du huo, Qiang hup, Mu gua, Wu jia pi, etc.)
• When the patient lacks breast milk and is Qi deficient, do not count on this herb to promote lactation.
• Hemostatic in surgery.
• Has been used for the treatment of hematuria.
• Traditionally this herb is powdered and taken directly. Too expensive to cook.
• Contraindicated in pregnancy.
• The unprepared form is black. The prepared form has been fried until yellowish.
• Though sometimes referred to as “anteaters,” pangolins are not true anteaters.

Chuan Xiong – Ligusticum root – Szechuan Lovage – Cnidium

Nature: acrid, warm

Enters: Pericardium, Liver, Gallbladder

Actions: Promotes blood and Qi circulation; eliminates external wind; relieves pain; moves Qi upward.

Indications:
• Blood (and Qi) stasis: irregular menstruation, amenorrhea, difficult labor, lochioschesis, and many kinds of pain, including abdominal, chest, flank, hypochondriac, dysmenorrhea, pain from traumatic injury, pain from carbuncles and boils, headaches, Bi syndrome.
• External wind disorders: headache, dizziness, painful obstructions, skin disorders; wind-damp arthritis/rheumatism.
• Reaches from the head down to the sea of blood.
• For a variety of wind patterns (wind-cold, wind-heat, wind-dampness, etc.) depending on the herbs it is combined with.
• Overdose may cause vomiting and dizziness.
Hsu: Antispasmodic, analgesic: inhibits intestinal and uterine contraction; slightly hypotensive; tranquilizer (essential oil); antibacterial, antifungal.
DY: Treats the Qi within the blood; dispels stasis; in the upper body, it goes toward the head and the eyes; in the lower body it goes toward the sea of blood (uterus [“Sea of Blood” may also indicate the Chong Mai or liver]); drying.
• For wind-cold (headache, etc.), use the uncooked form.
• For menstrual problems, pain, and inflammations, use the wine-processed form.
• With Dang gui to move the Qi and quicken the blood without damaging the blood, to nourish the blood without producing stasis, to dispel stasis and stop pain. For the following indications, both herbs should be wine-processed, though uncooked Chuan xiong may be used in the case of headaches or dermatological problems:
– 1. Menstrual irregularities, dysmenorrhea, and postpartum abdominal pain due to blood stasis that may be mixed with Qi stagnation. (Xiong Gui San)
– 2. Rheumatic pain due to wind-dampness and blood vacuity.
– 3. Headaches due to blood deficiency and/or blood stasis. (Jia Wei Si Wu Tang)
– 4. Wounds, ulcers, or enduring cutaneous inflammations due to Qi and blood vacuity with Qi and blood stagnation. (Tou Nong San)
• With Shi gao to dispel wind, clear and drain heat, quicken the blood and move the Qi, and stop pain. For headaches due to wind-heat or full heat (particularly that which is located in the Shaoyang or Jueyin channels). Use unprepared Chuan xiong. For wind-heat headaches, add herbs that dispel wind.
• Headaches: Chuan xiong is mainly used for wind-dampness and wind-cold headaches. However, it can be used for all kinds of headaches if combined appropriately. For wind-damp, add Qiang huo and Bai zhi. For wind-cold, add Fang feng and Jing jie. For wind-heat, add Ju hua and Bo he. For blood stasis, add Hong hua and Yan hu suo. For blood deficiency, add Dang gui and Ji xue teng. For full heat, add Shi gao and Zhi mu. For Qi stagnation, add Chai hu and Bai ji li. For liver Yang hyperactivity, add Tian ma and (Huai) Niu xi.
Weng Weiliang, et al: This herb is indicated in the treatment of headache, rheumatic arthralgia, abdominal pain with mass formation, pricking pain in the costal regions, swelling and pain due to traumatic injury, arthralgia due to cold, spasm of tendons, menstrual disorders, amenorrhea, dysmenorrhea.
HF: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).
SD: Chuanxiong is a frequently used Chinese herb, commonly called ligusticum or cnidium. The latter name is the term most often used in the ITM literature, adopted from the common name offered by Oriental Healing Arts Institute (OHAI) in publications 30 years ago. The herb has been obtained from Ligusticum chuanxiong (= Ligusticum wallichii) in China and from Cnidium officinale in Japan; the OHAI literature was heavily influenced by Japanese herb scholars. Recent evaluation of the genetic material of these two source materials has led to the suggestion that they are, in fact, the same plant, and that Cnidium officinale should be renamed as Ligusticum chuanxiong (1).
There are several active constituents in chuanxiong, but one of the most interesting is the alkaloid ligustrazine, which has the chemical name tetramethylpyrazine (because it is a pyrazine ring with four symmetrically placed methyl groups); it is sometimes simply called TMP. Isolated alkaloids from chuanxiong, and purified synthetic ligustrazine, have been used in China as medicinal agents for 30 years. The initial applications were based on traditional uses of the crude herb in decoctions and pills: for vitalizing blood circulation in the treatment of cardiovascular diseases
and for treatment of headache and vertigo.
LIGUSTRAZINE BY IV ADMINISTRATION
Ligustrazine is rapidly absorbed when taken orally, but it is also rapidly excreted in the urine. In order to maintain high blood levels, oral doses must be taken every few hours. Alternatively, ligustrazine can be given by IV drip over several hours to keep the blood levels high. Such administration is typical for hospitalized patients in China who have suffered heart attack or stroke and for treatment of serious childhood diseases (it is administered to infants who can not swallow herbal decoctions or pills). However, for most non-emergency uses, the IV form of administration is not convenient; further, it is not routinely available outside of China. Still, the IV use of this compound over the past three decades, both for adults and children, illustrates the lack of toxicity from TMP.
LIGUSTRAZINE BY ORAL ADMINISTRATION
Ligustrazine as a component of chuanxiong is only present in small amounts, perhaps 1%, so that a 9-12 gram quantity of the crude herb in decoction (as might be used in modern clinical practice in China) yields about 90 mg-120 mg of ligustrazine for a one-day dose. While this quantity may provide some benefits, contributing one active component to a complex mixture, it is not adequate to get the full benefit of ligustrazine that has been described in clinical and laboratory work with the isolated compound. Oral dosing of 100 mg or more each time, at least three times a day would be necessary to get sufficient blood levels for the desired effects.
To enhance the action of ligustrazine, even when given in adequate dosage, Chinese doctors often combine it with one or more herbs that have the related therapeutic action of vitalizing blood. The main herb used in combination with ligustrazine is salvia, either alone or with tang-kuei.
APPLICATIONS
The applications of ligustrazine in China are many, and at first may appear quite diverse. However, upon examining the various applications, one can appreciate ligustrazine as providing a “protective effect.” Following are brief reviews of a few of the uses of ligustrazine.
Renal failure and dialysis: Ligustrazine has been used to slow or halt the progress of renal failure in Chinese patients (2). Experimental studies have been conducted to demonstrate this effect in laboratory animals (3). One of the proposed mechanisms is the superoxide scavenging effect, one type of antioxidant action (4). Salvia has also been used to protect against renal failure (see ITM review: The use of salvia for patients with renal failure). Ligustrazine with salvia and tang-kuei have been used to aid patients undergoing renal dialysis (5). TMP is also used in conjunction with prednisone for patients with primary nephritic syndrome, which is said to function better than prednisone therapy alone (6). In the treatment of infants, ligustrazine was used to protect against the renal toxicity of gentamycin (7). Ferulic acid, possibly the primary active component of tang-kuei and one of the active components of chuanxiong, has shown benefits for treatment of patients with diabetic nephropathy (8).
Lung diseases with fibrosis: Ligustrazine is known to be a pulmonary vasodilator (9), but an area of particular interest is its action to protect against pulmonary fibrosis (10). Salvia and an active fraction of salvia (labeled IH764-3) have also been used for protection against pulmonary fibrosis (11-13), alone or with ligustrazine.
Neuroprotection for stroke: Chinese physicians have used chuanxiong and ligustrazine for treatment of stroke patients. Ligustrazine has been shown to have protective effects for the neurons, possibly based on anti-inflammatory activity (14-15). In clinical applications, ligustrazine in high dosage (480 mg/day) was found to lower fibrinogen and improve blood circulation in patients who suffered a stroke (16). Salvia is also known to confer neuroprotective effects in case of stroke (see review article: Neuroprotective herbs and active ingredients). Ferulic acid or its sodium salt (sodium ferulate) is used in Chinese medicine to treat stroke patients; in laboratory studies, it was shown to limit damage and help reactivation of impaired nerve cells (17).
In sum, ligustrazine alone or with salvia may provide protection to the kidneys, lungs, and brain through antioxidant and anti-inflammatory effects; these substances reduce fibrosis and improve blood circulation. The addition of tang-kuei, especially as a good source of ferulic acid (see structure, below), may further improve the effects.

Dose: 3-10g

Dan Shen – Salvia miltiorrhiza root – Red Sage – “Cinnabar Root”

Nature: bitter, slightly cold

Enters: Heart, Pericardium, Liver

Actions: Promotes blood circulation and dispels blood stasis; cools the blood; relieves swelling; mildly nourishes blood; calms the Shen; unblocks the menses.

Indications:
• Blood stasis: irregular menstruation, amenorrhea, abdominal pain after childbirth, pain in the chest, abdomen, epigastrium, masses and pain in the limbs, lochioschesis.
• Blood stasis with liver Qi stagnation: pain in the ribs or hypochondria.
• Heat in the blood and blood stasis: carbuncles, boils.
• Febrile disease (including Ying level): restlessness, delirium, high fever, eruptions, red tongue.
• Heat and blood stasis in the heart: insomnia, palpitations, irritability, restlessness. Also for heart/kidney Yin deficiency heat patterns.
• Primary herb for coronary heart disease in China. (Particularly in combination with San qi, Gui zhi, Shan zha, etc.)
• For immune system disorders Liu combines with Dang gui.
• For CNS-mediated pain, including post-stroke, combine with Huang qi in doses of 15-30g of each (when Qi deficiency and blood stasis are present)
• Promotes tissue regeneration; opens coronary arteries; reduces blood sugar; reduces serum cholesterol; protects the liver; enhances the immune system; vasodilator; relieves angina pectoris.
• Wine-frying the herb enhances its blood circulating properties.
• This herb can be compared to the formula Si Wu Tang, though Dan shen is weaker at nourishing blood and stronger at moving blood than Si Wu Tang.
• Do not use large doses in patients predisposed to bleeding.
• Note: the Salvia genus contains many herbs with drastically different properties – e.g., culinary sage – Salvia officinalis (also a diaphoretic), and the hallucinogenic drug Salvia divinorum. “Salvia” alone is not a sufficient name.
BII: May improve visual acuity in glaucoma.
MLT: Regulates cholesterol, triglycerides. Premiere herb for heart problems, especially angina.
Hsu: Dilates peripheral blood vessels, lowers blood pressure; strong antibacterial properties.
DY: Engenders new tissue; nourishes the heart.
• With Mu dan pi to quicken the blood and dispel stasis, cool the blood, and eliminate deficiency heat. For indications such as:
– 1. Hematemesis, epistaxis, metrorrhagia, purpura, and also rubella and pruritis due to heat in the blood division.
– 2. Menstrual irregularities, dysmenorrhea, amenorrhea, dark purple menstrual blood with clots, and postpartum abdominal pain due to heat in the blood which causes blood stasis.
– 3. Continuous, low-grade fever due to Yin deficiency heat. In this case, if there are night sweats, use Di gu pi instead of Mu dan pi.
– 4. Hot, red, swollen, painful joints due to hot Bi or impediment.
• With San qi to quicken the blood, dispel stasis, nourish the heart, open the network vessels, stop pain, and settle palpitations. For indications such as chest Bi or impediment, i.e. cardiac problems with pain and severe palpitations. For these indications, wine mix-fried Dan shen should be used. This combination treats heart pain no matter what the cause. This action may be reinforced by adding Shi chang pu, Xie bai, Gua lou pi, Gui zhi, and Tan xiang.
• With Tan xiang to regulate and rectify the Qi and blood, move the Qi and blood, free the flow of the network vessels, and stop pain. For the following indications, wine mix-fried Dan shen should be used:
– 1. Chest Bi or impediment, heart diseases with severe cardiac pain due to Qi and blood stasis. If heart blood stasis is severe, add San qi, Hong hua, and Yan hu suo. If Qi stagnation is severe, add Chen xiang and Qing mu xiang. If there is phlegm-damp obstruction in the chest, Gua lou pi, Jie geng, and Zhi ke. If there is chest Yang deficiency, add Xie bai, Gui zhi, and Fu zi. If there is Qi deficiency, add Huang qi, Zhi gan cao, and Ren shen.
– 2. Stomach pain due to Qi and blood stasis.
Dan shen has “very interesting action” on coronary heart disease, circulatory system diseases, and hypercholesterolemia.
Dan shen only mildly nourishes blood. To reinforce its supplementing action, it should be prepared with pig or tortoise blood.
Dan shen is incompatible with vinegar or any other very sour or acrid food.
IBIS: Occasional hypersensitivity may lead to excessive bleeding or fever.
Weng Weiliang, et al: Clinical studies excerpted from Weng Weiliang, et al., Clinical Chinese materia medica, Henan Science & Technology Press, 1998, retrieved HERE:
• Viral myocarditis: Experiential formula Si Shen Yin which consisted of dan shen 12g, hai er shen 12g, nan sha shen 9g, ku shen 9g, zhi gan cao 3g, guang yu jin 9g, chao zao ren 9g, lian zi xin 2g was made into granules to treat viral myocarditis. Twice daily, 1 pack every time. 39 cases were treated, the courses of treatment ranged between 20 to 60 days, and the clinic symptoms improved to different extent.
• Acute myocardial infarction: Dan Shen Injection 10g~24g was added into 500ml 5% glucose or low molecular dextran for intravenous drip. Once daily, 7~14 days as a course of treatment. 388 cases of acute myocardial infarction were treated, the incidence rate of heart failure was 29.9%, the mortality rate within hospitalization was 27.2%, which were lower that those in the control group but without statistic significance. The mortality rate in males was 16.2% and was significantly lower than that of the control group. No difference in female group.
• Diabetes: Compound Dan Shen Injection 8~12ml was added into 500m 0.9% NaCl Injection for intravenous injection, once daily, for 28 to 43 days. 120 cases of diabetes were treat, 50 cases were markedly effective, 55 improved, 15 had no changes.
• Hepatocirrhosis: 20ml Compound Dan Shen Injection was added into 250ml low molecular dextran for intravenous drip, once daily, 30 days as a course of treatment. 43 cases of hepatocirrhosis were treated, 10 were markedly effective, 28 effective, and 5 ineffective..
• Chronic simple rhinitis: 2ml Compound Dan Shen Injection (each ml contains 2g dan shen and 2g jiang xiang) was mixed with 2ml physiological saline solution for nasal drip to treat chronic simple rhinitis. Three times daily, 2 drops each side every time. 4 weeks as a course of treatment. 38 cases were treated, 22 were cured, 10 markedly effective, 3 improved, and 3 ineffective.
WIKI: Results from animal and human studies support the use of Danshen for circulatory disorders to some extent because it is known to decrease the blood’s ability to clot in at least two ways. First, it limits the stickiness of blood platelets. It also decreases the production of fibrin, the threads of protein that trap blood cells to form clots. Both these effects help to improve blood circulation. In addition, chemicals in danshen may relax and widen blood vessels, especially those around the heart. In animal studies, chemicals in danshen may also have protected the inner linings of arteries from damage. Some other research suggests it may increase the force of heartbeats and slow the heart rate slightly.
• In animal studies, Danshen has appeared to interfere with the development of liver fibrosis — the formation of scar-like fibers in the liver. Because the nonfunctioning fibers crowd out active liver tissue, liver function decreases gradually as the amount of fibrous tissue increases. Having chronic hepatitis and habitually drinking large amounts of alcoholic beverages are the major causes of liver fibrosis, which could also result from exposure to chemicals or certain drugs. Danshen may also increase blood flow into the liver, so the length of time that potentially damaging substances stay in the liver may be reduced, also reducing the possible injury they may cause. Results from a few animal studies showed it may also protect kidney tissues from damage caused by diabetes. In China, danshen has also been studied for treating acute pancreatitis, a painful and possibly dangerous inflammation of the pancreas. [23]
Salvia miltiorrhiza inhibits alpha-glucosidase activity.[24]
• Danshen may stop the spread of several different cancer cell types by interrupting the cell division process[25] and also by causing cancer cells to undergo cell death (apoptosis).[15] In contrast, the cerebrovascular protective effect of Salvianolic acid has been found to be due to prevention of apoptosis.[9]
• For HIV, chemicals in Danshen may block the effectiveness of an enzyme, HIV-1 integrase, that the virus needs to replicate.[26]
• Salvia may stimulate dopamine release and has protective effects against free radical-induced cell toxicity.[27][28]
S. miltiorrhiza stimulates increased osteogenesis in vivo (bone cell growth).[29]
• Salvianolic acid B could possibly facilitate the repair of tubular epithelial structures and the regression of renal fibrosis in injured kidneys.[30]
• Danshen has been shown to potentiate the effects of the common anticoagulation drug warfarin, leading to gross anticoagulation and bleeding complications. Danshen should be avoided by those using warfarin.[31]

Dose: 6-15g (up to 60g when used alone or in treating vasculitis)

E Zhu – Zedoaria rhizome – Curcuma zedoaria, C. aromatica, or C. kwangsinensis

Nature: acrid, bitter, warm

Enters: Liver, Spleen

Actions: Strongly promotes blood and Qi circulation and dispels blood stasis; dissolves accumulations, eliminates food retention; relieves pain.

Indications:
• Blood stasis: amenorrhea with abdominal pain and masses, ovarian cysts, fibroids, epigastric masses.
• Food retention: fullness, constriction, distention, pain in the epigastrium, chest, and abdomen.
• Childhood nutritional impairment.
• Controls some cancers – particularly cervical (especially grade II and below).
• Stimulates motility of GI tract.
• Its powerful nature can damage the Qi (do not use for long periods).
• This is the strongest herb in the pharmacopeia to eliminate food retention.
• Much stronger than Ru xiang and Mo yao to move blood and relieve pain.
• Often combined with San leng. Liu says E zhu is stronger than San leng at moving blood, but weaker than San leng at moving Qi. Bensky/Gamble says just the opposite.
• Fry with vinegar to enhance its blood circulating properties and stop pain.
• Kamto: San leng + E zhu is a great combination for treating depression.
RW: Carminative (a type of turmeric).
Li: (Often with San leng) for blood stasis in difficult skin conditions.
PCBDP: Aromatic; stimulant; treats some tumors.
Hsu: Some antihistamine effects; promotes resorption of coagulated blood; inhibits cancer cell growth; stomachic.
HF: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).
DY: Breaks the Qi and quickens the blood; treats the blood within the Qi; treats Qi stagnation which causes blood stagnation; tropism: liver, spleen, and Qi division.
• With San leng to strongly and effectively break both the Qi and blood, regulate and rectify the Qi and blood, stop pain, and reduce food accumulation. (Note that breaking the Qi and breaking the blood are both attacking methods that can damage the Zhen Qi if used inappropriately, too much, or for too long.) For indications such as:
– 1. Abdominal lump glomus, hepatomegaly, splenomegaly due to blood and/or Qi stasis. (E Leng Zhu Yu Tang)
– 2. Amenorrhea, dysmenorrhea, menstrual clots, and infertility due to blood stasis. (San Leng Wan) Both herbs should be vinegar mix-fried for these indications.
– 3. Abdominal pain due to food accumulation. (E Zhu Wan) Vinegar mix-fried E zhu should be used.

Dose: 3-9g

Hong Hua – Carthamus flower – Safflower – “Red Flower”

Nature: very acrid, warm

Enters: Heart, Liver

Actions: Promotes blood circulation, dispels blood stasis from the channels, opens the channels; alleviates pain; unblocks the menses.

Indications:
• Blood stasis: dysmenorrhea, amenorrhea, postpartum abdominal pain or dizziness, abdominal masses, lochioschesis, traumatic injury – wounds and pain, painful obstruction of the chest, non-suppurative sores, carbuncles.
• Heat and blood stasis: dark red skin eruptions, suppressed rashes, including measles.
• Beneficial in coronary artery disease. May also lower cholesterol.
• For Berger’s disease, combine with Ru xiang, Mo yao, Dang gui, Tao ren.
• For angina pectoris, often combined with Tao ren, Dan shen, Chuan xiong.
• Usually added near the end of cooking a decoction – should not be cooked long.
• Contraindicated in pregnancy.
• Bensky/Gamble: To harmonize the blood, use 0.9-1.5g.
Chen: Used successfully in one study to treat peptic ulcer.
DY: In a small dose (1-2g), it can slightly nourish blood. In a moderate dose (3-5g), it harmonizes the blood. At the usual dose (6-10g), it quickens the blood. At a high dose (10-15g), it breaks blood [stasis].
• Tends to dispel stasis in the upper part of the body and in the channels.
• With Tao ren: Hong hua is stronger than Tao ren at moving blood, while Tao ren is stronger at dispelling stasis. Together, they complement and reinforce each other to effectively quicken the blood, dispel stasis, engender blood, and stop pain. For such indications as:
-1. Cardiac and chest pain due to heart blood stasis. (Add San qi, Dan shen, Xie bai, and Gua lou pi.)
– 2. Amenorrhea, dysmenorrhea, menstrual irregularities, and dark menstrual blood with clots due to blood stasis. (Tao Hong Si Wu Tang)
– 3. Fixed, stabbing, and severe pain aggravated by pressure due to blood stasis. The combination appears in many formulas for these indications, based on the location and nature of the pain (Xue Fu Zhu Yu Tang, Tong Qiao Zhu Yu Tang, Fu Yuan Huo Xue Tang, Shen Tong Zhu Yu Tang, etc.).
– 4. Traumatic injuries with pain and swelling due to blood stasis. (Xiao Zhong Zhi Tong Tang)
MLT: Similar to, but stronger than Western Calendula.
PCBDP: Laxative, diuretic.
Hsu: Stimulates the uterus to contract rhythmically/tonically – particularly effective in pregnancy – fast, long lasting effect.
Dose:  3-10g (0.9-1.5 to harmonize blood) See comments from Dui Yao above.

Hu Zhang – Bushy Knotweed root and rhizome – Polygonum cuspidatum – “Tiger’s Cane”

Nature: bitter, cold

Enters: Liver, Gallbladder, Lung

Actions: Promotes blood circulation; relieves pain; eliminates toxicity; clears heat; drains dampness; resolves phlegm; stops coughing; slightly promotes bowel movement.

Indications:
• Especially indicated for a combination of phlegm, damp, heat, and blood stasis.
• Blood stasis: amenorrhea, traumatic injury, Bi syndrome.
• Damp-heat: jaundice, turbid vaginal discharge, painful urination.
• Heat-toxicity: burns, snake bites, skin infections, carbuncles. Often the fresh ground herb is applied topically.
• Lung phlegm-heat: cough.
• Heat accumulation: constipation (use 30g – discharges heat, toxicity).
• While in some users the laxative effect is minimal or absent, in others it can be significant.
• Guohui Liu: especially useful for hepatitis.
• Many constituents (resveratrol, piceatannol, polydatin, emodin) with medicinal properties elucidated through modern research:
– (from the scholarly folks at Herbal Vitality of Sedona) Anti-angiogenic (vitro), antibacterial against streptococci (vitro)/ vibrio (vivo), decreases histamine release (vitro), decreases COX-2 expression (vitro), anti-oxidant (vitro), antiviral – hepatitis B (vitro), anti-inflammatory (vivo), anti-allergenic (vivo), protects against burns (vivo), tyrosine kinase inhibitor, decreases oncogene function (vitro), neuroprotective (emodin / vivo), decreases leukopenia due to radiation (emodin / vivo), polydatin is cardioprotective (vitro) and decreases CAM expression (vivo), resveratrol has glucose regulating properties (vitro), inhibits cancer cell lines (vitro), decreases VEGF activity (vivo), decreases expression of NF-KappaB, COX-2, MMP9 (vivo), protects against bone loss (vivo), and is anti-inflammatory (vivo); piceatannol is hypolipidemic (vivo); stilbenes cause apoptosis of leukemic cells (vitro).
• Antiviral, antibacterial.
• Promotes leukocyte proliferation for leukopenia (particularly due to radiation or toxic chemicals).
• Contraindicated in pregnancy.

Examine.com on Resveratrol:
• Resveratrol is best known for its cardiovascular health benefits. In humans, resveratrol improves endothelial function and may have a blood-pressure-lowering effect in some populations. In vitro, resveratrol protects against atherosclerosis.
• In adults with type 2 diabetes, resveratrol improves fasting glucose, HbA1c, and insulin sensitivity but doesn’t appear to benefit adults without the disease. Resveratrol consistently reduces the inflammatory cytokines C-reactive protein (CRP) and TNF-alpha.
• Despite the plausibility of resveratrol’s potential effects on blood lipids and body composition, resveratrol doesn’t appear to improve blood lipids in adults with nonalcoholic fatty liver disease (NAFLD) or body composition in adults with cardiometabolic conditions.
• Resveratrol has poor bioavailability due to its rapid and extensive metabolism.
• The therapeutic dose of resveratrol ranges from 8.1 mg per day to 3,000 mg per day. Though human studies suggest resveratrol can be supplemented at dosages up to 5,000 mg (5 grams) daily with few to no side effects outside of some intestinal upset and nausea.
• Resveratrol doses of 1,000 mg/day or more may interfere with the biological effects of commonly administered drugs by inhibiting cytochrome p450 isoenzymes. For example, resveratrol inhibits enzymes that play a role in the metabolism of statins, calcium channel blockers, immunosuppressants, antifungals, non-steroidal anti-inflammatory drugs (NSAIDS), anticoagulants, beta-blockers, antidepressants, opioid analgesics, and antihistamines, among others.
• The cardioprotective effects of resveratrol are primarily due to its ability to protect cells against oxidative damage by scavenging free radicals and inhibiting their production. Resveratrol also increases antioxidant levels[22] and inhibits the production of pro-inflammatory cytokines (i.e., TNF-α, IL-1β, and IL-6). Resveratrol also appears to have anti-fibrotic and anti-hypertrophic effects in the heart and may improve mitochondrial biogenesis and function.
• Regarding its lipid-lowering and glucose-lowering effects, resveratrol activates the metabolic regulators AMPK and Sirt1, thereby improving lipid metabolism and fat accumulation in the liver and increasing glucose uptake into skeletal muscle (i.e., improving insulin sensitivity) — explaining resveratrol’s potential to treat nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and related conditions.

Dose: 9-30g

Ji Xue Teng – Millettia or Spatholobus root and vine

Nature: bitter, slightly sweet, warm

Enters: Liver, Heart, Spleen

Actions: Promotes blood circulation; mildly nourishes blood; relaxes the tendons; activates the collaterals, dispels stasis from the channels and collaterals; unblocks the menses.

Indications:
• Blood stasis: irregular menstruation, slow menstrual flow, dysmenorrhea, Bi syndrome.
• Blood stasis with blood deficiency: amenorrhea.
• Wind-dampness with blood deficiency or blood stasis: numb extremities, lumbar pain, knee pain, generalized joint soreness.
• Blood stasis or wind-stroke: weak extremities in the elderly, or paralysis and vertigo.
• For leukopenia from chemotherapy, radiation, aplastic anemia – combined with Dang gui, Bai shao, Shu di huang.
Hong teng – Sargentodoxa – (an herb that clears heat and eliminates toxicity) is used as this herb in many parts of China. It has none of Ji xue teng’s blood-nourishing properties or the ability to relax the tendons. Efforts should be taken to procure the correct herb if Ji xue teng’s unique properties are desired.
Hsu: Hypotensive.
Subhuti Dharmananda: May help antidote lead poisoning.
Millettia is the common name that has been selected to refer to the stems, obtained from several climbing legume shrubs containing a red resin, that are labeled as jixueteng in Chinese. The Chinese name describes the material as a stem (teng) with a sap having a color, which is reddish brown, reminiscent of dried chicken’s blood (ji = chicken; xue = blood). The main species used as sources of this herb are:
1. Spatholobus suberectus (most common species traded today and the official species in the Pharmacopoeia of the People’s Republic of China); see Figure 1; additionally Spatholobus harmandii and Spatholobus sinensis are used as substitutes.
2. Millettia dielsiana, Millettia nitida, Millettia speciosa, Millettia gentliana, Millettia reticulata, Millettia pachycarpa.
3. Mucuna birdwoodiana, Mucuna sempervirens, Mucuna castanea.
This group of plants represents a relatively recent addition to the Chinese Materia Medica, first recorded two centuries ago in the Bencao Gangmu Shiyi (Omissions from the Grand Materia Medica, 1765 A.D.), where it was said that it “activates blood, warms the waist and knees, and cures paralysis caused by wind.” This herb is not included in any of the commonly mentioned traditional herb formulas from the Qing Dynasty (1644–1911 A.D.).
Jixueteng did not have a strong reputation among traditional herbalists during the 20th century prior to the 1980’s. In Medicinal Plants of East and Southeast Asia (1), a compilation of information gathered during 1959–1961, the genera listed above are mentioned:
· Under the heading Mucuna it is stated that “Mucuna is scarcely worth mentioning medicinally.” The limitedinformation for this genus is that it “is a tonic.”
· Under the heading Millettia, it is stated that it “has few uses from the Malay Peninsula and Indonesia;” some mention of the leaves and root are made, but not of the stem; as to Chinese use, it is mentioned that Millettia dielsiana is “employed locally in Yunnan as anti-anemic; a new compound was isolated from the reddish bark; Millettia pachycarpa is used as a tonic and to induce the growth of red blood cells.”
· For Spatholobus, Chinese uses are not mentioned, though applications in Burma and Indonesia include: “ingestion of the sap as a treatment for faulty menstruation and uterine hemorrhage; an infusion of the stem is taken also to treat cough and fever.”
Jixueteng was deemed inconsequential enough that it was not included in the Synopsis of the Pharmacopoeia (2) prepared at the American College of Traditional Chinese Medicine in 1984, though the authors mentioned the herb in some sample prescriptions for recovering the hemopoietic system in their 1980 booklet Treatment of Toxic Side Effects Resulting From Radiation and Chemotherapy by Traditional Chinese Medicine (17). The herb is also absent from many of the illustrated Materia Medica guides that were compiled during the 1980’s. In the
book Aging and Blood Stasis (32), written by a physician who worked from the 1930’s to the 1980’s, jixueteng, commonly classified as an herb for promoting blood circulation and treating blood stasis, is not included in any of the prescriptions. The situation has changed dramatically in recent years: millettia has been elevated to one of the commonly used herbs of modern Chinese medicine.
TRADITIONAL ACTIONS AND INDICATIONS
The traditional actions of jixueteng mentioned in modern works, such as Chinese-English Manual of Common-Used Herbs of Traditional Chinese Medicine (3), are: “To enrich the blood and promote blood circulation, relax tendons and activate meridians.” Traditional indications are: “For blood deficiency and blood stasis syndrome manifesting as anemia, menalgia (painful menstruation), menoxenia (menstrual bleeding), or soreness, numbness, and immovability of extremities.” As another example, in Modern Study and Application of Materia Medica (43), its actions are: “To tonify the blood and activate its circulation, relieve rigidity of muscles and joints, and promote menstruation.” The indications are “Arthralgia due to wind and dampness, aching pain in the waist and knees, numbness of the extremities, malnutrition of the muscles and tendons, and irregular menstruation and amenorrhea due to deficiency of the blood.”
Depending on the source book consulted, jixueteng is found classified either as a blood nourishing herb, along with tang-kuei, peony, rehmannia, and ho-shou-wu, or as a blood vitalizing herb, along with salvia and red peony. In recent attempts to classify the blood vitalizing herbs into subgroups, Li Lianda (21) placed millettia along with tangkuei, moutan, salvia, raw rehmannia, and red peony as “mildly active herbs, nourishing the blood to promote circulation.”
C.S. Cheung (24) explained the close relationship of generating blood and vitalizing blood this way: The essence of fluid and grain is injected into the meridians and forms yingqi. It then circulates to the heart and transforms into blood. The blood flows to every part of the body and moistens and lubricates all tissues. When there is insufficiency of yingqi, the vaporization [dispersement] of qi is endangered. Thus, the blood does not flow smoothly, encouraging the formation of blood stasis and ecchymosis [congealed blood, outside the vessels]. New blood is unable to be generated when obstructed by stasis and ecchymosis. Consequently, therapeutic measures are taken to remove the obstruction and regenerate blood.
For this function, Cheung mentions the herbs tang-kuei, salvia, millettia, and turtle shell. Under millettia, he describes the functions as “tonifies and circulates blood, loosens ligaments, vitalizes the luo vessels, eliminates blood stasis and ecchymosis, and generates new blood and tissue.” The indications given are “blood deficiency diseases involving the meridians, draft wetness, numbness, cold pain.”
Qin Bowei (23), a famous herbalist of the 20th century, stated that: In harmonizing the blood, jixueteng is best at quickening the network vessels and freeing the channels. Cooked into paste, it is referred to as Jixueteng Jiao and is particularly strong. Yu Nanzhi [a famous herbalist] refers to this as a great supplementer of qi and blood, being most appropriate in geriatric and gynecological illnesses.
References to “activate meridians,” “vitalize the luo vessels,” and “free the channels” are translations of the Chinese term tongmai. Mai is the general term that means a vessel, channel, meridian, or a passageway, and the term is used in the modern medical sense of blood vessel. Tong means to be able to pass through or, as an activity, to make passable. Thus, tongmai indicates that use of the herb makes it possible for the qi and blood to flow through the meridians without obstruction. Where there is obstruction, one can experience pain, numbness, swelling, and stiffness. In general, the method of activating meridians is based on warming up the yangqi to promote vigorous movement.
The ability of millettia to supplement qi and blood, vitalize blood, alleviate cold pain, and free the channels brings to mind a traditional formula with similar properties: Huangqi Guizhi Wuwu Tang (Astragalus and Cinnamon Five Herb Combination) comprised of astragalus, peony, cinnamon, ginger, and jujube. Designed long before millettia was added to the Chinese Materia Medica, this formula is from the Jin Gui Yao Lue (ca. 220 A.D.). A modification of the formula was recommended by Wang Weilan (25) for treating soreness and weakness in the back and knees and numbness of the extremities in persons with qi and blood deficiency. To the traditional formula, he added tang-kuei, millettia, red peony, citrus, and chin-chiu (this last herb is often prescribed when there is a wind-damp syndrome in persons of deficiency constitution). He  particularly favored the combination of millettia with red peony in formulas for bi syndrome (arthralgia, numbness) to vitalize the blood, open the luo vessels, relax the ligaments, and relieve pain. In explaining bi syndrome, he stated that:
Deficiency of the normal qi is the basis of the internal factor and leads to the looseness of the cutaneous tissue [openness to external influence] and the lowering of the body’s resistance. If the external factor is the contraction of cold in winter, then the cold evil can take the opportunity to enter the weak and deficient body and to directly strike at the ligaments and bones, thus causing internal damage to the blood and the meridians, qi stagnation, blood stasis and ecchymosis, and limitation of movements….
According to this interpretation, herbs that enhance qi and blood, dispel the cold, and vitalize blood are of particular importance; hence, millettia is a key herb in treating bi syndrome in persons with deficiency syndrome.

RECENT APPLICATIONS OF MILLETTIA
It is the purported ability of millettia to aid the production of blood cells that has captured the attention of several Chinese researchers. A formula was developed for this purpose called Tang-kuei and Millettia Combination (Danggui Jixueteng Tang), recorded in the book Zhongyi Shanke Xue (Chinese Medicine for Blood Disorders) and relayed in Thousand Formulas and Thousand Herbs of Traditional Chinese Medicine (4):
Tang-kuei and Millettia Combination
Tang-kuei 15 g
Millettia 15 g
Rehmannia 15 g
Salvia 9 g
Peony 9 g
Longan 6 g
This formula follows the principle of vitalizing blood to generate new blood and nourishing blood to aid circulation of blood; it is indicated for “advanced stage of bone [marrow] injuries with qi and blood deficiency, or for the tumors with white blood cell or platelet reduction during chemotherapy or radiation therapy (4).” In modern practice, astragalus is often included in formulations of this type to treat the qi deficiency and aid in the generation of blood, even though millettia has been said to have the ability to generate qi.
A number of basic preparations of millettia have been described in recent literature. Millettia paste was mentioned in the Annals of Shunning Fu (40), where it was stated that: “When combined with carthamus, tangkuei, and oryza, and cooked into paste, jixueteng is a sacred herb for blood diseases.” Millettia Wine and Millettia, Shouwu, and Longan Wine are mentioned as treatments of wind diseases and blood deficiency syndrome: millettia, as a single herb, for bi syndrome (arthralgia and myalgia), and the three-ingredient wine for “lassitude of extremities,
dizziness, palpitation, insomnia, early greying of hair, and pallor due to deficiency of both qi and blood (41).”
Millettia Sugar Broth, in which jixueteng is decocted and combined with 40% its weight of sugar, and used for treating loss of blood and anemia, is mentioned in Chinese Medicinal Herbs (40). Millettia usage in food therapy has also been described (44, 45). Millettia is boiled with eggs (after the egg is hard boiled, the shell is removed, and the egg returned to the decoction for continued cooking); sometimes jujube is included. Then, the eggs are eaten and the decoction drunk as a treatment for anemia. A tablet made of jiexueteng extract as the sole ingredient, Jixueteng Qingao Pian, is produced by the Shanghai Native Medicine Works; it is described as a treatment for bi syndrome; amenorrhea or dysmenorrhea due to deficiency of blood and/or stagnation of blood; and increasing white blood cell count in cancer patients who suffer leukopenia due to chemotherapy or radiation (42). Jixueteng injection has also been prepared in China (37). In Dictionary of Chinese Medicine (40, 43), the simple decoction of 30 grams millettia given daily on a long term basis was reported helpful for leukopenia induced by radiation therapy. During the 1980’s and up to the present, several clinical trials were conducted involving treatment of leukopenia and thrombocytopenia in which millettia was included in the herbal formulas and results of the therapy were reported in Chinese medical journals.
REVIEW OF HERB THERAPIES TO COUNTERACT CHEMOTHERAPY-INDUCED LEUKOPENIA
In an extensive review article (Countering the side effects of modern medical therapies with Chinese herbs), the use of formulas that had been reported, according to the results of clinical trials, as successfully countering leukopenia was presented. The descriptions of formulas that contained millettia and the results claimed from giving them to patients are relayed again here, with slight editing of information from the previous article and a few additions.
The Astragalus-Jujube Combination (Qi Zao Granule) was applied to treating white blood cell suppression from various causes (5). The formula is comprised of 18 grams each of astragalus, jujube, millettia, and hoelen, concentrated into extract granules. According to the clinical report, patients with white blood cell counts below 3.5 were treated for 20–30 days with this mixture: 56% of the patients had their white cell counts increased by at least 4.0 above the initial value and 24% had the white cell counts increased at least 1.0 above the initial value; granulocytes similarly increased. The figures for the response of the control group were 25% and 5% respectively. The same formula was used in the treament of cor pulmonale (22), with lymphocyte transformation rate depressed by the treatment, indicating that the primary effect in leukopenic patients was to benefit white blood cell production.
An expanded version of that formula was clinically tested for cancer patients with impaired immune functions (6). The prescription, Shengxue Tang (Generate Blood Decoction), is made with 30 grams each of astragalus and millettia, and 10–15 grams each of hoelen, lycium fruit, pseudostellaria, ligustrum, and cuscuta (the latter four herbs replacing jujube in the Astragalus-Jujube Combination). According to the clinical report, 242 cancer patients, mostly having stomach or intestinal cancer, and being diagnosed as having spleen-qi deficiency, were administered this formula. After only a few days of treatment (each course of therapy was only 2–3 days), macrophage phagocytosis, lymphocyte transformation rates, E-rosette formation rates, and killing ability of natural killer cells of peripheral blood were significantly increased.
Although reversal of leukopenia was not a direct outcome measure for the study of Shengxue Tang, the prescription is similar to others that were demonstrated to have that outcome. For example, another version of this formula, labeled Fuzheng Zengxiao Fang, was reported to ameliorate leukopenia, as well as to significantly reduce the experience of fatigue and gastro-intestinal distress in cancer patients undergoing chemotherapy (7). The formula is comprised of astragalus, millettia, lycium fruit, ligustrum, pseudostellaria, atractylodes, asparagus, and carthamus (thus, hoelen and cuscuta in Shengxue Tang are replaced by atractylodes, asparagus, and carthamus).
In another study, patients completing treatment with chemotherapy and radiation therapy (mainly for lung and esophageal cancers) were then administered a modified version of Shiquan Dabu Tang (Ginseng and Tang-kuei Ten Combination), with the added herbs: millettia, polygonatum, lycium fruit, ho-shou-wu, cornus, lotus seed, and dioscorea. After 30 days administration of the herbs to 60 patients, it was reported (8) that there were statistically significant improvements in total white blood cells, natural killer-cell rate, and ratios of CD2, CD4, and CD8.

Another formula of similar nature was used in a study (9) on the side effects of cancer therapy in patients with many types of cancer. The formula is:
Huten Tang
astragalus 40 g
millettia 30 g
hoelen 30 g
hu-chang 30 g
cuscuta 20 g
lycium fruit 15 g
psoralea 15 g
tang-kuei 15 g
atractylodes 12 g
licorice 10 g
Hu-chang and millettia (both used to boost white blood cells) were deemed the main herbs in the formula. The herb therapy was initiated 3–5 days prior to starting chemotherapy and continued until one week after finishing chemotherapy. The effectiveness of the therapy was evaluated by considering a broad set of indicators, such as red and white blood cell levels, extent of gastro-intestinal reactions, avoiding loss of hair, and improving tumor shrinkage. According to the author, 39% of the patients had an excellent outcome, and 43% had a notably effective response,
while only 7% failed to respond at all. This prescription is an elaboration of one described for leukopenia due to radiotherapy (40), which is comprised of 30 grams each of hu-chang, millettia, and tang-kuei (all used for building blood), along with 9 grams of licorice.
A formula relying on similar key herbs and the same basic therapeutic principle was used for 60 cases of leukopenia (38), given astragalus, millettia, hu-chang, psoralea, gelatin, polygonatum, rubia, and jujube. It was reported that 52 of the patients had marked improvement in the lymphocyte counts, and that the average hemoglobin and platelet counts also increased.
The same basic principle of therapy was utilized in another trial (11) involving patients being treated mainly for tumors of the lung, breast, and stomach, with the following formulation:
Fuzheng Guben Fang
astragalus 40 g
ho-shou-wu 40 g
millettia 30 g
oldenlandia 30 g
pseudostellaria 30 g
gelatin 20 g
licorice 20 g
ligustrum 20 g
rehmannia 20 g
atractylodes 15 g
peony 15 g
tang-kuei 15 g
The formula was modified to address specific symptoms. The herbs were given along with chemotherapy, while a control group received Western drugs, vitamins, and berbamine (an herbal leukocyte raising alkaloid derived from sankezhen: Berberis soulieana) along with their chemotherapy. According to the report, the formula prevented the decline in leukocytes better than the control treatment, and the patients also had fewer other side effects, such as nausea and weariness.
In a review (12) of herbal treatments for granulocytopenia (a type of leukopenia), 28 recipes that were reported to be highly effective were analyzed. It was found that the most commonly used herb ingredients were astragalus (in 21 formulas) and jixueteng (in 20 formulas), followed by salvia (in 13 formulas), psoralea (in 12 formulas) and tangkuei (in 11 formulas). Other herbs that were used repeatedly but in fewer than 10 formulas each were ligustrum, jujube, lycium fruit, epimedium, licorice, and hu-chang. A tablet made primarily with the commonly used herbs,
including psoralea, epimedium, ligustrum, astragalus, jujube, tang-kuei, salvia, millettia, and hu-chang, and also containing placenta, cornus, and sanqi (13), was given to cancer patients who suffered leukopenia due to cancer chemotherapy as well as others suffering from leukopenia due to other causes (e.g., chronic hepatitis, drug poisoning, radiation, and unknown causes). According to the report, after a course of treatment of two weeks (15 tablets per day, each tablet 1.85 grams of herb material), leukopenia was completely reversed in 49% of patients and another
29% showed marked improvement in leukocyte counts.
In a mouse study of herbal effects on cyclophosphamide-induced leukopenia, a mixture of astragalus, hu-chang (hu zhang), and millettia (Huanghuji Mixture) was compared to the effect of hu-chang alone and with the effect of vitamin B4. According to the report (14), hu-chang had the greatest effect, with the Huanghuji mixture slightly less effective, and vitamin B4 having a relatively weak effect.
According to a review of cancer therapy approaches used in China (27), the herbal combination Dao Jing Tong #17, with main ingredients millettia, salvia, and curcuma, was reported to enhance the action of the anti-cancer drug camptothecin against leukemia and it protects against pulmonary fibrosis caused by radiation therapy (these effects were reported in mice studies). It was also reported that “Various preparations for raising the white cell count have been made with the following ingredients: Illicium verum (dahuixiang), sophora, and millettia. They have been used in hundreds of cases of radiation and chemotherapy induced agranulocytosis.” These three herbs are in the legume family (see: Legumes).
THROMBOCYTOPENIA
Millettia has been incorporated into several modern prescriptions for treating thrombocytopenia. For example, in a series of reports (10, 33), Fu Xian Tang, also called Sanyao Fang: a decoction made with 30 grams each of millettia and agrimony, and 9 grams of rumex (suanmogen), was given for treatment of thrombocytopenia (33). It was reported that 57 of 62 cases had their platelet count raised to over 100,000. This response occurred within one week for most patients. As another example, a decoction of 15–30 grams each of astragalus, millettia, and codonopsis, 10–30 grams each of tang-kuei and cnidium, 8–10 grams carthamus, and 10–30 grams each of red peony and leonurus, was given one dose per day to patients for an average of one month each (range: one week to two months). In all of the 18 cases of idiopathic thrombocytic purpura (ITP), the platelet count increased to greater than 100,000, but the effects were short-lasting in all but 5 cases (15).
In a study of 46 cases of ITP, patients were divided into two groups: those with blood stasis syndrome and those with spleen deficiency syndrome (26). For the former group, the general prescription given (which could be modified for individual cases) was comprised of millettia, red peony, rubia, tang-kuei, salvia, codonopsis, jujube, eclipta, and rehmannia (separately, a cup of tea made from notoginseng flowers was given). Of the 30 cases with the blood stasis type, the treatment was deemed markedly effective or effective in half the cases, and there was some improvement in all but three cases. The average course of therapy was 12 weeks.
A study of three treatments for ITP was conducted using either prednisone, coenzyme A, or a Chinese herb decoction (29) made with 20 grams each of astragalus and polygonatum plus 12 grams atractylodes to tonify qi, 15 grams each of millettia and tang-kuei to nourish and vitalize blood; 12 grams each of red peony and moutan to vitalize blood and cool blood heat; and 10 grams of carthamus to vitalize blood and resolve stasis. Treatments were administered for 4–8 weeks. According to the study report, prednisone had the strongest effect (82% rate of improvement), Chinese herbs had a good effect (65% rate of improvement), and coenzyme A had only a slight effect (35% improvement, but none markedly effective).
Patients with advanced gastric adenoma undergoing chemotherapy were treated (16) with Shengxue Tang, a decoction containing astragalus, millettia, ligustrum, cuscuta, lycium, pseudostellaria, atractylodes, and hoelen; it was reported that six weeks administration along with the chemotherapy resulted in increased platelet counts.
Patients with acute leukemia often suffer from thrombocytopenia, since the cancerous stem cells that produce leukocytes crowd out the cells that produce platelets. In a study of combined Chinese medical and Western medical treament of acute leukemia (49), 30 patients received standard chemotherapy alone (as a control) or in combination with a decoction made from two types of jixueteng (30 grams each of Spatholobus and Mucuna) and 15 grams of another member of the legume family that has similar actions, moghania (yitiaogen), plus a complex formula
containing cynanchum, frankincense, phragmites, hoelen, cissus, pueraria, rehmannia, polygonatum, ligustrum, and oldenlandia (each herb in dosages of 10–30 grams). According to the report, in addition to improving the level of platelets and red blood cells, the herbs contributed to a higher rate of remission than in the control group (83% vs. 63%) and a longer average duration of remission (390 days vs. 268 days).
DOSAGE AND COMBINING
The dosage recommendations for millettia vary among the Materia Medica descriptions. The frequently cited dosage ranges are 9–15 grams per day or 15–30 grams per day, but some sources mention up to 60 grams per day. In one book describing individual species (45), for Millettia nitida, a therapy using 60–120 grams per day was mentioned for anemia. Among the clinical reports reviewed here for which dosage was mentioned, 30 grams per day seems to be the standard amount used, though some formulas included only 15–18 grams. Millettia is frequently incorporated into prescriptions of 8 or more ingredients, but in four of the clinical reports mentioned above, it was used in small formulas with only 2–3 other herbs. Most commonly, millettia was combined with astragalus, lycium fruit, ligustrum, rehmannia, and tang-kuei in formulas for generating blood cells.
TOXICITY, ADVERSE EFFECTS, AND CONTRA-INDICATIONS
No reports of toxicity or adverse reaction to millettia have appeared in the Chinese literature available to ITM. In one report (37) on the safety of jixueteng injection (with Spatholobus suberectus specified as the source material), it was stated that its tolerance dose in mice was 200 times the therapeutic dose and that the LD50 in mice was over 100 g/kg, a huge amount. No irritation was induced by injecting the drug into different sites in rabbits. It did not cause allergic reaction in guinea pigs. If injected into mice at high dosage for several days after initiation of
pregnancy, it reduced the pregnancy rate; this effect was not observed in rats, however. High doses of millettia (15– 30 grams/day or more), such as used in correcting leukopenia, should not be used during pregnancy; in general, Chinese literature recommends avoiding blood-vitalizing herbs during pregnancy, with certain limited exceptions.
ACTIVE CONSTITUENTS
At this time, it is not clear which active constituents of jixueteng are responsible for the claimed effects of the herb in complex formulas, though it appears likely that the flavonoids are the dominant constituent of interest. There is a deficiency in information about the constituents and pharmacology in the literature that may reflect the fact that there are so many different source species involved. The Leguminoceae, family to which all the jixueteng species belong, provides four basic types of active constituents:
1. Flavonoids, which are the dominant group of active constituents for this plant family—found in most of the species in significant quantities—such as those from soybeans (e.g., genistein and diadzein) that have become well-known (see: Flavonoids for health; Soybeans for health). Psoralea, which is used with some frequency in the formulas for treating leukopenia, is a legume that is rich in flavonoids.
2. Alkaloids, such as oxymatrine and matrine found in sophora root, which also have the effect of protecting bone marrow functions (see: Sophora);
3. Saponins, including triterpenes, that are reputed to promote blood circulation, improve oxygen utilization, and protect against adverse influences (adaptogenic effect); and
4. Polysaccharides, such as those contained in astragalus, that are reported to counteract the bone marrow suppression induced by chemotherapy and to enhance macrophage functions (see: The physiological responses to immunologically-active polysaccharides);
Thus far, there have been no reports of medicinally active polysaccharides or alkaloids in jixueteng. Several flavonoid compounds have been identified for Millettia pachycarpa (18) and for Millettia reticulata (19). These are polymethoxyflavones, isoflavones, and flavonoid alcohols. Spatholobus suberectus, the most commonly used source of jixueteng in China today, was analyzed to reveal the following constituents (34, 40):
· Isoflavones similar to genistein (these are found also in pueraria flower and root, sophora tops, licorice root, wisteria, and soy bean): formononetin, ononin, afromosin, diadzein
· Chalcones (a group of flavonoids, found also in licorice root and sophora tops): isoliquiritigenin, tetrahydroxychalcone, licochalcone
· Coumestans (a group of flavones, found also in sophora tops, better known in alfalfa): medicagol
· Condensed flavonoids (also known as tannins and found in many herbs, notably green tea): epicatechin
· Other flavonoids: pruetin, cajinin, methoxyhydroflavonol
· Triterpenes: friedelan, taraxerone
· Sterols: beta-sitosterol, daucosterol, methoxycoumesterol, camphesterol, stigmasterol
· Phenolic organic acids: protocatechuic acid
Flavonoid compounds similar to those in Spatholobus have been found in other herbs that are reputed to have blood-vitalizing activity, such as dragon’s blood (Daemonorops draco: xuejie), sappan (Caesalpinia sappan; sumu) and dalbergia (Dalbergia odifera: jiangxiang); the latter two herbs are in the same plant family as millettia. Like the jixueteng vines, these other herbs have red resins; in fact, sappan was long known in Europe as brasil wood, which means “red dye” wood (the country of Brazil, where this plant was found growing, is named after it). The millettia flavonoids have platelet aggregation inhibiting effects and coronary dilating activity that helps explain their use in treating cardiovascular diseases (19). While many flavonoids are colorless, there are some that are pigments, such as afromosin in Spatholobus and brasilin in sappan. It is possible that the traditional Chinese focus on red colored herbs—originally selected because of the ancient concept that these were affiliated with blood circulation—has resulted in use of a group of herbs with highly effective blood-vitalizing flavonoids, some of which are red pigments.
NON-LEGUME SUBSTITUTES FOR JIXUETENG
A study of market materials used for jixueteng reveals that the following are also used (30, 31): Kadsura interior, Kadsura heteroclita, and Schizandra propinqua of the Schizandra Family (formerly included in the Magnolia family) and Sargentodoxa cuneata (of the Lardizabalaceae). Kadsura species are widely used in Chinese medicine; for example, kadsura bark (zijingpi) is said to invigorate blood circulation, disperse swelling, remove toxin, clean blood, regulate menstruation, and promote urination; kadsura rhizome (haifengteng) is said to remove wind and
dampness and promote the flow of meridians; and kadsura root (hongmuxiang; meaning fragrant red wood) is reported to move qi, invigorate blood, and control pain. These are properties attributed to jixueteng as well. Schizandra, a close relative, is usually used as a source of medicinal fruits, but it is the stem that is used for jixueteng. Sargentodoxa cuneata is known as hongteng (red stem) or as xueteng (blood stem) and is said to remove toxins and furuncles, invigorate blood circulation, promote the flow of channels, dispel wind, and kill intestinal parasites. Like the legumes that give rise to jixueteng, these plants have a red color and are reputed to promote circulation of blood. The active constituents have not been analyzed.
MECHANISM OF ACTION ON HEMOPOIETIC SYSTEM
In a recent study (20) of treatment of aplastic anemia, two formulas with jixueteng (one for invigorating yang, one for nourishing yin) were evaluated (dosages are in grams per day):
Jixueteng Zhengyang Tang
Millettia 100
Astragalus 60
Eclipta 30
Ligustrum 30
Ho-shou-wu 24
Cuscuta 18
Epimedium 18
Psoralea 12
Tang-kuei 12
Fenugreek 6
Placenta 6
Ginseng 3
Jixueteng Yijing Tang
Ligustrum 100
Eclipta 100
Rehmannia 90
Millettia 30
Ho-shou-wu 30
Astragalus 30
Salvia 24
Cuscuta 12
Gelatin 9
Lycium 9
Psoralea 6
Tang-kuei 6
The formulas were administered according to the primary diagnosis of either dominant yang deficiency or dominant yin deficiency. In certain circumstances, additional herbs and/or hormone therapy would be used as deemed necessary. Red blood cells, white blood cells, and platelets all increased significantly after patients received the herb treatment for several months (up to 2 years for this study). Bone marrow biopsies were used to evaluate the condition of the bone marrow before treatment (in 106 patients) and then after treatment in 45 patients who had good results based on their blood picture. According to the authors:
Before treatment, there were nucleated cells in 84% (89/106) among the cases with low hemopoietic tissue in the bone marrow, which had been replaced by fatty tissue. Re-examination of 45 cases after treatment showed hyperactive proliferation of bone marrow in 40 cases (89%), the lipid cells decreased, the percentage of granulocytic, erythroblastic, and megakaryotic series increased significantly, and the islands of erythroblastic series could easily be seen. The marrow vascular network was significantly reduced before treatment, even to the extent that no small vessel or capillary was found in sections from 22/106 cases (21%), and expanded and broken sinuses were found. After treatment, the number of vessels significantly increased and the morphology of the sinuses and capillaries became normal with intact wall structure. The reticulofibrosis (RF) of marrow increased after treatment and most of them were fine in appearance, distributed scantily in tissues. No cases showed RF of high degree [diffuse fibroreticulation accompanied with either scattered coarse fibers or local collagen fibrosis]….Study of the bone marrow matrix showed that the increase of vascular network, restoration of vascular structure, and proliferation of RF may be due to the more active new vessels and increased secretion of RF from adventitial reticulocytes to construct the matrix skeleton.
Although aplastic anemia differs from bone marrow suppression via chemotherapy or radiation, it is possible that improved microcirculation in the marrow vascular network could also explain some of the effects of millettia on the cancer therapy induced bone marrow suppression. In the cancer cases, the physical damage to the bone marrow is less than in aplastic anemia (at least, initially), but the impairment of stem cell activity might be accompanied by reduced microcirculation. Along these lines, it is of interest to note that another herb, hu-chang, frequently used with millettia in the formulas, has been classified as a blood vitalizing herb in several Chinese texts (sometimes, it is classified among the heat and toxin clearing herbs). In the Bencao Gangmu Shiyi where millettia was first recorded, it is commented that (40): “the decoction of hu-chang is effective for diseases of the bone joints and blood stasis.” It is possible that these two herbs are useful in the complex prescriptions for bone marrow disorders because of their contribution to bone marrow microcirculation. When accompanied by other herbs, such as those that contain
polysaccharides that may stimulate the bone marrow cells (e.g., astragalus, lycium, epimedium), the bone marrow may be able to function optimally within the limits imposed by the potent activity of the anticancer drugs or repeated radiation exposure.
In a study of mechanism of action of herbs on the bone marrow (28), researchers administered herbs to mice with cyclophosphamide-induced marrow suppression in three combinations:
1. A blood vitalizing combination comprised of 15 grams each millettia and salvia.
2. A kidney tonifying combination comprised of 30 grams each rehmannia and ho-shou-wu, plus 15 grams each of ligustrum, psoralea, and cistanche.
3. A combined therapy group with all seven of the above herbs.
According to the study analysis, the kidney tonification herbs (#2 above) enhanced the growth of marrow progenitors for granulocyte-macrophages (thus benefited leukocytes), while the blood-vitalizing group promoted the erythroid progenitors (thus increased red blood cells) and improved marrow stroma function (which benefits the granulocyte-macrophages). The combined therapy produced greater increases in each of the bone-marrow cell-lines than the component parts. The combination kidney-tonifying and blood-vitalizing therapy was given to 50 patients suffering from aplastic anemia (most patients also received stanazol); it was reported that 41 of them (82%) responded well, an improvement compared to the 57% of patients responding well to stanazol alone. Among 9 patients who received only the herbs, 5 had remission and 2 showed marked improvement.
Proposed mechanisms by which the bone marrow was restored by the herbal treatments included removal of sialic acid from cell membranes resulting in proliferation signaling, increase in cytokines that stimulate the stem cells, and restoration of superoxide dysmutase function. Electron microscope studies indicated that the blood-vitalizing herbs and the combined kidney-tonic and blood-vitalizing therapy were better than the kidney-tonifying therapy alone at recovering the micro-environment [capillary bed] of the bone marrow.
OTHER USES
In recent practice, jixueteng appears in several formulas reported in Chinese clinical trials for treating cardiovascular diseases, liver fibrosis, rheumatoid arthritis, sciatica, and skin diseases. However, the formulas are quite large, and several of the herbs contained in them are known to have the desired effects, so the role of millettia in these treatments is unclear.
As an example of the applications to treat skin ailments, following are two prescriptions with millettia from a literature review related in the book Treatment of Psoriasis with Traditional Chinese Medicine (35):
· Jinyin Huzhang Tang: 15 grams each of lonicera, hu-chang, salvia, millettia; 12 grams each of raw rehmannia, red peony, sophora flower, 9 grams isatis leaf
· Buxue Qufeng Tang: 30 grams each of astragalus, millettia, and polygonum stem; 15 grams each of raw rehmannia, and dictamnus; 12 grams each of codonopsis, tang-kuei, trichosanthes, and isatis leaf; 9 grams clematis; and 5 grams each of angelica, siler, and citrus.
Following is a formula that was reported useful for treating vitiligo in a clinical trial involving 30 cases (36):
· Huoxue Qufeng Tang: salvia, cnidium, millettia, tang-kuei, moutan, tribulus, schizonepeta, saussurea, magnetite (proportions not given).
The next formula was prescribed for chronic skin ulcers (39):
· Guizhi Tang Jiajian: cinnamon, peony, ginger, jujube, licorice, millettia, smilax, coix, tang-kuei, atractylodes, cyathula (proportions not given); it was reported that 41 of 48 patients suffering from skin ulcers due to persisting wound infections, burns, or varicose veins were cured.
In all of these treatments for skin ailments, millettia is combined with tang-kuei or salvia or both. These herbs are used to nourish blood and vitalize blood circulation.
As examples of using millettia to treat bi syndromes, a review of formulas in the book Bi Syndromes (46) provides the following modern modifications of traditional formulas (name of traditional formula given, followed by ingredients of modified version):
· Sanbi Wan: tu-huo, chin-chiu, clematis, stephania, chaenomeles, trachelospermum, eucommia, astragalus, cyathula, millettia, loranthus, tang-kuei, siler, cinnamon, and baked licorice. This is recommended for early stage arthritis, involving influence of wind, cold, and dampness (the three inducers of bi, sanbi).
· Fangfeng Tang: siler, ma-huang, tang-kuei, chin-chiu, pueraria, chiang-huo, schizonepeta, millettia, trachelospermum. This is indicated for “wandering bi,” in which the painful sensation migrates, rather than being always in a fixed location.
· Tao Hong Siwu Tang: astragalus, tang-kuei, codonopsis, cnidium, salvia, rehmannia, persica, carthamus, millettia, earthworm. This is used for skin bi, such as scleroderma, in persons with qi deficiency and blood stagnation syndrome.
· Shiquan Dabu Tang: ginseng, astragalus, rehmannia, tang-kuei, cinnamon, salvia, hoelen, millettia, baked licorice. This is used for blood vessel bi, such as arteritis, in persons with qi and blood deficiency syndrome.
· Shentong Zhuyu Tang: persica, carthamus, frankincense, myrrh, tang-kuei, cnidium, millettia, cyathula,liquidambar, chiang-huo. This is used for tendon bi, such as contracting pain in the limbs, in persons with blood stagnation syndrome.
· Wang Qiuzhou Tang: morus twig, kadsura, millettia, siegesbeckia, cinnamon, cnidium, peony, red peony, myrrh, frankincense; this is used for tennis elbow.
In addition, a patent remedy developed during the 1980’s, Yao Tong Ling (Anti-Lumbago Tablets, different than the one commonly marketed in the U.S.) is mentioned. It is comprised of tu-huo, chiang-huo, chin-chiu, kadsura, millettia, carthamus, tang-kuei, cnidium, asarum, cinnamon, eucommia, and rehmannia. Millettia has been included in other recent patent products, such as Duzhong Hugu Wan for chronic bi syndrome due to liver and kidney deficiency, and Mugua Wan for limb numbness and weakness (42, 48).
In all of these formulas for bi syndromes, millettia is accompanied by some of the ingredients of Siwu Tang, Tang-kuei Four Combination.
To treat multiple sclerosis, which involves limb numbness and paralysis, Chinese physicians have recommended formulas that include millettia (47). As examples:
· For deficiency of qi and weakness of the kidney: astragalus, morinda, cibotium, ophiopogon, cuscuta, pueraria, chaenomeles, achyranthes, tortoise shell, and millettia.
· For deficiency of kidney and liver, with phlegm-obstruction of the channels: tang-kuei, curcuma, rehmannia, hoelen, acorus, silkworm, ho-shou-wu, salvia, chaenomeles, peony, cnidium, millettia, and zizyphus.
In these formulas, millettia is combined with chaenomeles to treat stiffness of the extremities.
It can be seen, from the limited presentation of modern uses of millettia, that this herb has rapidly moved from obscurity to prominence in the practice of herbal medicine. No doubt, the increasing reliance on millettia will lead to further analysis of its constituents, pharmacology, and clinical application.
Dose: 9-15 (to 30g in severe cases)

 

Ji Xue Teng Jiao:
• This is Ji xue teng made into an enriched syrup by concentrating it and adding malt sugar syrup and extracts of Hong hua, Niu xi, Xu duan, and black beans.
• Slightly sweet, astringent, aromatic, warm.
• Similar effect to Ji xue teng, but stronger at nourishing blood.
• Dissolve it into a strained decoction.
Dose: 4.5-9g

Jiang Huang – Turmeric rhizome – Curcuma longa – “Ginger Yellow”

Nature: acrid, bitter, warm

Enters: Liver, Spleen, Stomach

Actions: Strongly promotes blood circulation; dispels blood stasis from the channels and collaterals; relieves pain; unblocks menstruation; disperses wind-cold; promotes Qi circulation.

Indications:
• Blood stasis: pain in the shoulder, chest, hypochondria, abdomen, and amenorrhea, dysmenorrhea. Especially effective for shoulder pain.
• Wind-cold-dampness: Bi syndrome, especially in shoulders, limbs.
• Blood stasis due to cold from deficiency.
• Topical: stops bleeding and pain.
• Can be made into an ointment with oil.
• Cholagogue.
• Stimulates the uterus.
• Lowers blood pressure.
• Curcuminoids, thought to be the primary active components (with curcumin being the most researched), are notoriously poorly absorbed. In Ayurveda, turmeric is often routinely combined with pippali (Bi Bo) and/or black pepper (Hu Jiao), to help its absorption. Interesting, a number of classic martial arts hit formulas (die da jiao) include the combination of Jiang Huang and Bi Bo. It’s now known that Bi Bo and Hu Jiao contain piperine, which enhances absorption of other compounds (and is used commercially as an absorption enhancer with a variety of nutritional supplements).
• One study showed piperine (the active pungent compound in black pepper – hu jiao – and pippali – bi bo) can dramatically increase the absorption of curcumin (perhaps as much as 2000%). [Planta Med. 1998 May;64(4):353-6. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.]
MLT: Increases bile flow, reduces liver enzymes SGOT and SGPT, prevents and dissolves gall stones.
• Anti-inflammatory, analgesic for sports injury, musculoskeletal trauma, inflammatory bowel disease, arthritis, rheumatoid arthritis.
BII: Contains curcumin – a powerful and safe anti-inflammatory; protective against cancer development.
• Possible uses in: atherosclerosis, cancer, gallbladder disease (curcumin increases bile acid output over 100%, and greatly increases the solubility of bile – may prevent and treat gall stones), rheumatoid arthritis, general inflammation.
Yoga: Haridra: K-; P, V+ (in excess)
• Stimulant, carminative, alterative, vulnerary, antibiotic while improving digestive flora.
• Gives the energy of the Divine Mother and grants prosperity.
• Cleanses the chakras, purifies the channels of the subtle-body.
• Helps stretch the ligaments, good for the practice of hatha yoga.
• Promotes proper metabolism.
• Topical: sprains, strains, bruises, itching.
Hsu: Increases the detoxifying abilities of liver.
• Stimulates the uterus to contract (paroxysmally).
• The ethanol extract is hypotensive.
CHA: (Karen S. Vaughan, 8-30-2001) Fungal infections of the feet: soaking the feet in a turmeric footbath is part of Ayurveda and is also done in traditional Hawaiian medicine.
Weil: Knee arthritis: This research, from Italy, was a three-month trial involving 50 patients diagnosed by x-ray with osteoarthritis of the knee. The Italian team was investigating the effect on arthritis symptoms of a special formulation of turmeric designed to improve its absorption by the body. Half the participating patients took the turmeric formulation in addition to standard medical treatment; those in the second group continued following their physicians’ recommendations.
After 90 days, the researchers found a 58 percent decrease in overall reported pain and stiffness as well as an improvement in physical functioning among the turmeric group compared to the controls. These changes were documented with a standard medical scoring method used to assess symptoms of knee and hip osteoarthritis. In addition, another scoring method showed a 300 percent improvement in the emotional well being of the turmeric patients compared with the others. And blood tests showed a 16-fold decline in C-reactive protein, a marker for inflammation. Patients in the turmeric group were able to reduce their use of non-steroidal anti-inflammatory drugs by 63 percent, compared to the other group.
Results of this study are very good news for the millions of people worldwide who suffer from osteoarthritis and haven’t been adequately helped by available treatments. The dose of the turmeric formulation used in the study was one gram per day. It is now commercially available in the United States and Europe.
Turmeric may also be useful for prevention of symptoms of rheumatoid arthritis, but this evidence comes from animal studies, not human trials.
Research also suggests that turmeric may prevent changes that lead to Alzheimer’s disease, and animal studies have shown that turmeric may be effective in the prevention or treatment of colon, breast and prostate cancers.

Dose: 3-9g

On Curcumin/Curcuminoids from Examine.com:
Curcumin is the yellow pigment associated with the curry spice, Turmeric, and to a lesser extent Ginger. It is a small molecule that is the prototypical ‘curcuminoid’, and has effects similar to other polyphenols but unique in a way as it is a different class of polyphenol (relative to the other classes of ‘flavonoid’, ‘stilbene’, etc.)

It exerts potent anti-inflammatory effects, and these anti-inflammatory effects seem to be quite protective against some form of cancer progression. However, curcumin has additional anti-cancer effects that are independent of its anti-inflammatory effects and thus is a heavily researched molecule for both cancer prevention and treatment.

Other areas of interest as it pertains to curcumin are alleviating cognitive decline associated with aging, being heart healthy by both electrical means and reducing lipid and plaque levels in arteries, and both reducing the risk of diabetes and being a good treatment for the side-effects associated with diabetes.

It has a poor oral bioavailability (a low percentage of what you consume is absorbed) and thus should be enhanced with other agents such as black pepper extract, called piperine. This is unless you want the curcumin in your colon (as it is a colon anti-inflammatory and can help with digestion), in which case you wouldn’t pair it with an enhancement.

Doses up to 8g curcuminoids in humans have been shown to not be associated with much adverse effects at all, and in vitro tests suggest curcumin has quite a large safety threshold.

A good general intake of curcumin, as a supplement, would be 500mg of curcuminoids that is enhanced in some manner. 500mg of curcumin with 20mg piperine, or 500mg of curcumin microsomes or curcumin phosphatidylcholine.

For any effects on colon and intestinal tissue (colon cancer prevention, reducing inflammation associated with Crohn’s, etc.) it would be good to use a dose of 2-4g curcumin or turmeric without any enhancement.

Benefits have been seen with as little as 100-200mg turmeric sprinkled on curry, so even if you don’t supplement it would be prudent to use some turmeric in daily life.

1.1. Sources

Curcumin (Diferuloylmethane) is the main active ingredient of the spice Turmeric (also known as Curcuma Longa or JiangHuang), which consists of Curcumin as well as thee other curcuminoids (Demethoxycurcumin , Bisdemethoxycurcumin, and Cyclocurcumin)[1][2] in which curcumin can consist of up to 80% of curcuminoids by weight, dependent on location of growth.[3] Both curcumin and Ginger belong to the family of Zingiberaceae known as the ‘Ginger Family’.

Curcuminoids appear in the entire Curcumin genus, although most commonly in Longa. Curcumoinds exist in:

Curcuma Longa (Turmeric, or JiangHuang) at around 22.21-40.36mg/g in the rhizomes and 1.94mg/g in the tuberous roots
Curcuma Phaeocaulis at 0.098mg/g in the rhizomes
Ginger
Shampoo ginger (Zingiber zerumbet L)

Other names for curcumin can be NCB-02 (a standardized mixture of curcuminoids), E100 (code used for food coloring), MERIVA (curcumin bound to soy lecithin, or phosphatidylcholine) and THERACURMIN (curcumin microsomes).

Commercially available extracts of ‘curcumin’ may not be wholly curcumin, but a blend consisting of 77% curcumin (17% demethoxycurcumin, 3% bisdemethoxycurcumin, last 3% not classified but assumed to possess a cyclocurcumin content).[11]

1.2. Structure and Properties

The structure of curcumin, officially known as diferuloylmethane, is two ferulic acid moeities bound together with an additional carbon to abridge the carboxyl groups. It can exist in a enol form (pictured below) or a keto form, which is molecularily symmetrical with two ketone groups on the backbone.

Curcumin is the compound in Turmeric which exert the characteristic bright, yellow color of Turmeric. Due to its intense coloration, it is sometimes used as a food additive with the code of E100.[12][8]

Curcumin is lipophilic and highly insoluble in water, and is acid-stable when measured around the pH of the stomach.[13]

2. Pharmacology

2.1. Absorption

Due to the poor intestinal absorption, however, curcumin is effective in reaching colonic tissue. An oral dose of 3.6g curcumin (which has been shown to increase plasma levels to 11.1+/-0.6nmol/L[14]) is able to increase the levels of curcumin in colorectal tissue to 7.7+/-1.8nmol/g (normal) and 12.7+/-5.7umol/g (malignant).[14]

2.2. Systemic

Curcumin, due to its lipophilicity, is transported in the blood via transports; most likely binding to Human Serum Albumin.[15]

Without aiding absorption, an oral dose of 500mg/kg bodyweight in rats results in peak plasma levels of 1.8ng/mL.[16]

When investigating humans oral dosages of 2, 4, and 8g curcumin daily for 3 months results in circulating levels of 0.51+/-0.11, 0.63+/-0.06, and 1.77+/-1.87uM; respectively. These Cmax values were attained around 1-2 hours post-administration and then rapidly declined.[17] Another human study found that 3.6g of curcumin resulted in levels of 11.1+/-0.6nmol/L an hour after consumption, with the lower dose tested (0.45g) not able to influence serum levels of curcumin;[14] this dose is about 1/45th the circulating amount of the 4g curcumin dosage in the previous study, and the reason for discrepancy is unclear.[17][14][18] Higher dosages induce a Cmax of 2.30+/-0.26 ?g/mL (10g) and 1.73+/-0.19 ?g/mL (12g); the reason for the drop in Cmax is unknown, but hypothesized to be due to saturation of the transporters.[19]

Increasing the oral dose to 10g induces an AUC of 35.33+/-3.78 ?g/mL, and a 12g dose induces an AUC of 26.57+/-2.97 ?g/mL.[19]

2.3. Bioavailability

The efficiency of an oral dose in increasing plasma levels of curcumin (bioavailability) is poor;[20] due to this, methods are being investigated to increase bioavailability. One clinical toxicology study in humans looking at oral curcumin found that doses below 8,000mg didn’t influence serum levels significantly, but only doses of 10g or 12g[21] (although some studies do note serum spikes at 4g).[17]

Pairing Curcumin with Piperine, a black pepper extract that is also an inhibitor of glucuronidation enzymes in the intestines and liver, is able to increase bioavailability 20-fold (2000% of baseline values) when 20mg piperine is paired with 2g curcumin.[22]

Complexing curcumin with phospholipids (a phosphatidylcholine-curcumin complex known as Meriva) can increase its incorporation into lipophilic membranes, increasing Cmax and AUC five-fold in rats[23] and making 450mg Meriva as effective as 4g curcumin in humans (unpublished trial).[18] Other trials suggest a factor of 29-fold higher absorption in humans, although said enhanced absorption favors demethoxycurcumin rather than curcumin.[24]

Beyond Piperine and Phospholipids, nanoparticle emulsions show promise. THEACURCUMIN emulsion (nanoparticles) possesses a 40-fold higher AUC (Area-under-Curve) when compared to basic curcumin power in rats, and a 27-fold higher AUC in humans.[10] although another study found merely a 10-fold increase in AUC and a 40-fold increase in Cmax in rodents.[25] This increased bioavailability is, in part, due to increased water-solubility.[26] Usage of nanoparticles can be used up to 210mg without any apparent saturation in absorption, and increase to Cmax to 275+/-67ng/mL, an AUC of 3,649+/-430 ng/ml/h, and a half-life of 13+/-3.3 hours.[26]

For any systemic purpose, it would be wise to increase curcumin bioavailability; either by taking it with a meal and piperine (Black Pepper) or one of the enhanced delivery systems. If using curcumin for any effects on the colon, poor bioavailability is desirable (if not absorbed, it heads to the colon) and no measures for bioavailability enhancement should be made

2.4. Metabolism

The major metabolites of curcumin in humans are curcumin sulfate (via sulfation enzymes of P450) and curcumin glucuronide (via glucuronidation by P450).[16][14][19]

In the bile, tetrahydrocurcumin and hexahydrocurcumin have been noted in rats, and to a lesser degree dihydroferulic acid and ferulic acid.[27]

2.5. Excretion and Clearance

One study using an intravenous dose of curcumin at 40mg/kg bodyweight in rats noted that the dose of curcumin was essentially cleared from plasma after one hour.[16]

3. Longevity and Life Extension

3.1. Autophagy

Autophagy is a Longevity associated process involving selective destruction of damaged cellular organelles, sometimes described as cellular housekeeping or maintenance;[28][29] autophagy appears to activated by many polyphenols[30] including curcumin, Resveratrol, silybin (from Milk Thistle), Quercetin, and catechin (common, but usually known to be a component of the four Green Tea Catechins).

Curcumin (and the metabolite tetrahydrocurcumin [31]) appear to induce autophagy via Akt/mTOR/p70S6K and ERK1/2 signalling pathways (inhibition and activation, respectively[32]) and so far has been detected in glioma,[32] uterine,[33] oral cancer,[34] and leukemic cells.[31] In drosophilia, flies with mutations in the osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, or age-1 genes fail to have life extension from curcumin[35] although mev-1 and daf-16 appear to be indepednent.[35]

Beyond the possible roles in longevity, autophagy promotion from curcumin is thought to be protective against gliomas[36][37] as glioma cells are resistant to apoptosis but readily destroyed by autophagy.[38][39] Parkinson’s pathology may be attenuated with curcumin via preservation of autophagy[40]

Curcumin appears to induce autophagy secondary to beneficial modulation of mTOR and ERK1/2 signalling (inhibition and activation, respectively) which may underlie both longevity promoting and select anti-cancer effects

3.2. Interventions

In drosophilia, curcumin can induce longevity via antioxidative properties[35] independent of caloric restriction yet is not complementary with caloric restriction (suggesting acting upon the same pathway)[41][42][43] with most efficacy at 100mM of the feed.[41] Interesting, administration of curcumin for an entire lifespan has been shown to have a possible suppressive effect on longevity but administration for youth (drosophilia health span, which is about the first 30% of life) prolonged median and maximum lifespan by 49% while administration during middle age (up to 45% of lifespan) had less promotion and administration in older age (senesence) reduced median lifespan by 4% (although maximum still increased 11%).[41]

Curcumin has been shown to promote longevity independent of caloric restriction in fruit flies, and appears to have more potency in youth than in older individuals (where some suppressive effects on lifespan are noted)

The metabolite of curcumin, tetrahydrocurcumin, appears to promote longevity in male mice by 11.7% at a dietary intake of 0.2% tetrahydrocurcumin, but is dependent on administration as youth.[44] This study failed to note an effect when mice started curcumin feeding at 19 months (the above results noted with earlier feeding at the 13th month), suggesting the youth requirement extends to mammals.[44] Longevity enhancement in mice has been noted elsewhere.[45]

Conversely, one mouse study has noted a failure of curcumin to enhance lifespan when given at similar doses and times in F1 hybrid mice, despite caloric restriction being effective[46] and lifetime administration of curcumin (0.2%) starting at 4 months has also failed to promote lifespan in UM-HET3 mice.[47] Assuming a food intake of around 8.55g/45g bodyweight[48] and body weights around 45g for the majority of the life[46][47][44] an estimated intake of curcumin daily would be 17.1mg (converting to 380mg/kg bodyweight and an estimated human dose[49] of 22.8mg/kg or 1.5g for a 150lb person)

There is some promising, but currently mixed, evidence to support the role of curcumin in anti-aging. This may follow the same motifs of requiring ingestion of curcumin in youth or at least prior to midlife,

It is an unproven but attractive theory that curcumin works via Chaperone-mediated autophagy (covered on the Longevity page) due to both being prolongevity yet less effective in aged subjects (due to decreasing LAMP-2A expression)

4. Cellular Mechanisms

Curcumin is able to induce effects either directly (the first domino in a series) or downstream of the primary effect (subsequent dominoes). This section serves to differentiate the two and harmonize mechanisms.

4.1. Direct

AP-1, a class of transcription factors made of dimerizations of c-Fos, c-Jun and related proteins that is involved with cell proliferation, survival, and differentiation[50] bind to their receptor on the cell nuclear (TPA response element) to induce effects associated with AP-1.[51][52] The effects of AP-1 differ depending on the proteins that make it up, but curcumin is able to interfere with the AP-1 released by tumor promoters[53] and is able to enhance some phase II (anti-oxidant) enzymes by moderating some better AP-1 confirmations.[54]

Curcumin is also seen as a direct mTOR inhibitor, able to prevent the association of the raptor subset with the TOR protein, inhibiting mTORC1 activity directly without significant influence from AMPK-TSC or Protein Phosphatase A2.[55][56]

Curcumin can also directly inhibit DNA polymerase lambda,[57] focal adhesion kinase (FAK),[58] Src,[58] Protein Kinase C,[59] p300 (CREB Binding Protein),[60] Thioredoxin reductase,[61] Lipoxygenase (LOX),[62] and tubulin.[63]

It may also directly affect (negatively) 17beta-HSD3[64] and 5-alpha reductase.[65]

Curcumin has been noted to directly and potently inhibit the Glycogen Synthase Kinase-3? (GSK3?) enzyme with an IC50 of 66.3nM.[66]

4.2. Junction points

Junction points are defined as proteins or receptors that, by their activation or inactivation, influence a great deal of related proteins.

nF-kB, a proinflammatory transcription factor, is inhibited by curcumin via a two-fold mechanism of preventing p65 translocation to the nucleus, and by preventing the degradation of the molecule which holds nF-kB in a dormant state, IkB.[67] The co-activator of nF-kB, Notch-1, is also suppressed by curcumin although abnormally high levels of Notch-1 can reduce the inhibitory effects of curcumin on nF-kB.[68] nF-kB moderates over 200 related proteins related to cell proliferation, invasion, metastasis, chemoresistance, and/or inflammation.[69][11]

As mentioned previously, the proteins of AP-1 are also seen as a sort of junction point mediating cell proliferation and survival.[50]

4.3. Indirect/Downstream

The main proteins and molecules that are downstream of nF-kB, and thus are reduced in potency when nF-kB is inhibited, are Bcl-2, Bcl-xL, cyclin D1, interleukin-6 (IL6), cyclooxygenase 2 (COX2) and matrix metallopeptidase-9 (MMP9).[70][71][72]

5. Cardiovascular Health

5.1. Cardiac Tissue

Curcumin is suspected to be able to protect against cardiac hypertrophy, inflammation, and thrombosis via inhibition of the protein p300, a Histone acetyltransferase (HAT) and it’s downstream pathways. This inhibition has been shown to prevent heart failure in rats.[73]

5.2. Endothelium

Via induction of Heme-Oxygenase 1 (HO-1), curcumin can prevent the endothelial (blood vessel) dysfunction associated with high blood glucose in a dose dependent manner and may offer protection from side-effects associated with diabetes.[74] In an animal model of diabetes, curcumin has also preserved a degree of endothelial health during disease progression (although it was unable to, at 200mg/kg bodyweight, prevent changes).[75]

This protective effect has also been demonstrated with LPS insult, a pro-inflammatory condition, and curcumin dosed at 50-100mg/kg bodyweight in rats;[76] changes in endothelial contractability (via TNF-a) have also been reduced with curcumin.[77] Protection from L-NAME induced hypertension has also been seen.[78]

In regards to blood pressure, one human study has noted significant decreases in blood pressure but was conducted in a nephritic disease state.[79] Not much human evidence looks at the effects on blood pressure in otherwise healthy individuals.

Appears to hold protective effects on blood vessels, but its clinical significance is not known; seems promising, and most likely mediated through Heme Oxygenase-1

5.3. Triglycerides

500mg curcumin daily has been shown to reduce triglycerides by 47% (110+/-21mg/dL to 58+/-9mg/dL) over 7 days, while a higher dose of 6g reduces triglycerides by 15% (93+/-13mg/dL to 79+/-11mg/dL); the cause for the lowered efficacy of high doses is not known.[80] These were seen in otherwise normal weight and healthy young subjects.[80]

5.4. Cholesterol

500mg curcumin daily has been demonstrated to reduce total cholesterol levels by 17% while a higher dose of 6,000mg reduces total cholesterol by 5% in otherwise healthy subjects.[80]

6. Interactions with Neurology

6.1. Cognition

One study assess curcumin and cognitive injury noted that, in control rats that were not injured, curcumin at 500ppm was able to increase BDNF levels to approximately 140% of control; this was independent of significant changes to CREB (105%) and phosphorylated CREB (93%).[81]

6.2. Stress

In vitro, curcumin can abolish the induction of the NMDA receptor subunit R2B mRNA by corticosterone[82] when corticosterone is incubated at 0.1mM and curcumin at concentrations as low as 0.62uM;[83] this may be related to the ability of curcumin in vitro to prevent corticosterone-induced neuronal death.[83]

Curcumin at 5, 10, and 20mg/kg was fed to rats daily for 21 days, and upon being subject to acute stress and subsequent cognitive testing; curcumin dose-dependently reduced the negative influence of stress on spatial memory with both higher doses (10, 20mg/kg) being significant and slightly less effective than 10mg/kg imipramine.[83]

6.3. Neuronal Injury

Curcumin at 500ppm in rats (a dose similar to some anti-Alzheimer’s dosages[84]) for 4 weeks on either a high fat or normal diet who were then subject to a fluid percussion injury noted that the increased oxidation in the brain (139% normal diet, 239% high fat diet; high fat did not induce oxidation without neural injury) was reduced to 45-47% in both groups and BDNF was normalized despite its inherent reduction in neural injury,[81] and other proteins that tend to be reduced in this form of injury are somewhat normalized with curcumin.[85] Cognitive performance was declined after injury, and the reduction was attenuated but not normalized.[81]

6.4. Alzheimer’s Disease

Curcumin is able to inhibit aggregation of beta-amyloid proteins in the brain, and thus prevent neural inflammation which would normally be downstream from said aggregation. The former has been noted in vivo[86] and has been hypothesized to be the reason as to why higher circulating levels of Beta-Amyloid have been noted (statistically insignificant) with curcumin supplementation[87] as beta-amyloid is prevented from aggregating in the brain,[88] and thus must circulate somewhere.

Mechanistically, curcumin may be able to reduce Beta-amyloid build-up in neural tissue

In a rodent model with advanced Alzheimer’s Disease characterized by beta-amyloid accrual, curcumin was able to attenuate the decline in neural performance and was synergistic with DHA; a component fatty acids from Fish Oil.[89] This synergism may be related to how both agents can reduce beta-amyloid aggregation, but by differing mechanisms;[90][91] some authors hypothesize that this synergism may be further enhanced by exercise[92] due to an interaction with exercise and fish oil on neuronal plasticity.[93]

A 6-month trial has been conducted on Curcumin and Alzheimer’s, using basic curcumin at either 1 or 4g daily for 6 months in a population of 50+ year old chinese persons suffering from cognitive decline for at least 6 months prior to trial onset. Scores on the MMSE, a rating scale for Alzheimer’s, increased progressively in the placebo (indicating cognitive decline) but were mostly static in both curcumin groups.[87] This trial is limited in statistical power due to its sample size of 27 completions and multiple confounds, however.[87]

Some therapeutic promise, but evidence is limited

7. Implications for Digestion and the Intestines

Curcumin tends to be most relevant to the colon due to its poor oral bioavailability. Oral bioavailability is a measure of how much of a molecule as a percentage is absorbed from the gut, and whatever is left over (in this case, a large amount) is carried on to the colon where it may interact with colonic microflora or the colonic walls.

7.1. The Colon and Ulcerative Colitis

One double-blinded multicenter study noted that, in conjunction with standard therapy for Ulcerative Colitis, 2g of curcumin daily (1g with two different meals) was able to confer significant protection against colonic inflammation and improve symptoms of Ulcerative Colitis for as long as it was used.[94] Less mortality and relapse was noted with curcumin usage, but the difference was not significant 6 months after cessation of usage like it was for the 6 months it was being used for.[94] These effects were seen earlier in both Ulcerative Colitis and Crohn’s Disease, two human conditions associated with intestinal inflammation.[95]

8. Interactions with Glucose Metabolism

8.1. Mechanisms

In liver cells, Curcumin at 20uM appears to activate Adenosine Monophosphate Kinase (AMPK) to the same degree as Metformin (2mM), which is 400-fold more potent on a concentration basis.[96] Although glucose uptake into cells tends to be secondary to AMPK activation[97] and has been noted with both Metformin and another potent AMPK activator Berberine, this study noted that Curcumin failed to induce glucose uptake, instead noting a trend to reduce glucose uptake.[96] This inhibition of glucose uptake has been noted elsewhere, where 100uM Curcumin was shown to inhibit insulin-stimulated GLUT4 translocation[98] despite curcumin twice being shown to not significantly interact with the insulin receptor itself (not cell type specific).[99][96]

Remarkably potent AMPK activator, yet seems to fail at inducing glucose uptake into cells (and thus undermines many of the inherent benefits of AMPK as it pertains to diabetes)

8.2. Blood glucose

The effect of curcumin to lower blood glucose was one of the first effects to be seen with curcumin, seen in 1972.[100][101]

One of the mechanisms of this blood glucose lowering effect is by stimulating Adenosine Monophosphate Kinase (AMPK) in skeletal muscle, drawing in glucose.[102] This effect is enhanced with the presence of insulin, and since insulin also activates the PI3K pathway curcumin appears to be synergistic with insulin in regards to reducing blood sugar levels.[103] Curcumin can also activate AMPK in other cells, such as liver cells[96] and some cancer cells.[104]

8.3. Diabetes

Curcumin is able to alleviate the downstream inflammatory reactions that occur during times of diabetes and metabolic syndrome in rats[105] and, vicariously through its anti-inflammatory effects, improve insulin resistance.[106][105]

9. Interactions with Fat Mass

9.1. Mechanisms

Curcumin has been noted to attenuate lipolysis induced by TNF-? and isoproterenol (representative of catecholamines) in 3T3-L1 adipocytes, which was thought to be secondary to suppression of ERK1/2 activation.[107] ERK1/2 is known to be regulated by AMPK[108] which curcumin has been found to activate[109] (in liver cells, this was noted to be of comparable potency to Metformin but requiring 20uM to Metformins 2mM[96]); all of these events being similar to the known AMPK activator Berberine.

Fatty Acid Synthase (FAS) is inhibited by Curcumin with an IC50 of 26.8?M (59.1?M in regards to ?-ketoacyl reduction); the inhibition was noncompetitive when NADPH was the substrate, but mixed competitive with either acetyl or malonyl Coenzyme A[110] and had both slow and fast acting components in a concentration and time dependent manner.[110] 20uM of Curcumin abolished lipid accumulation in isolated 3T3-L1 cells undergoing differentiation, which may have been due to downregulation of PPAR? and CD36;[110] another study notes that PPARy activation by Curcumin is dependent on AMPK activation.[109]

Curcumin appears to be a potency activator of AMPK

9.2. Inflammation (Adipose Tissue)

Inflammation appears to play a role in obesity, particularly one cytokine known as TNF-?; adipose of genetically obese mice overexpress TNF-? which is also seen in adipocytes of overweight individuals[111] and TNF-? expression appears to negatively correlate with LPL activity.[112] TNF-? itself does exert lipolytic activity,[113] so its elevation in obesity may be as a biomarker of underlying dysregulation rather than a per se contributor; the possibility of TNF-? resistance (a phenomena similar to insulin resistance, as TNF-? has its own receptor class on adipocytes[114]) also being possible.[111] TNF-? is a potent activator of nF-kB (nuclear receptor) which mediates many of its effects,[115] and overactivity of nF-kB and TNF-? in adipocytes are both highly correlated with metabolic syndrome and obesity.[111]

In general, excessive inflammation in adipocytes (assessed by looking at biomarkers thought to be representative of inflammation such as TNF-?) is highly correlated with obesity and metabolic syndrome; interventions which reduce inflammation in adipocytes tend to also be those that can reduce fat mass in persons suffering from excessive inflammation

A reduction in immune cell infiltration in adipose tissue has been noted in vivo when mice are given 3% curcumin in the diet for up to 4 weeks, as assessed by histological examination.[105]

9.3. Adipokines

Curcumin appears to be associated with an increased FOX01 transcription activity and increased adiponectin production in vivo (with higher circulating levels of adiponectin noted in both genetic and diet induced obesity, but lean control mice did not experience an increase);[105] FOXO1 is known to positively influence adiponectin transcription in fat cells.[116][117]

Leptin secretion from adipocytes appears to be suppressed with 12 and 24 hour incubation with Curcumin in a concentration and time dependent manner.[118]

9.4. Interventions

In obese mice given curcumin (3% of feed), despite noting an increase in food intake relative to control; this reduction in body fat was not observed in normal mice.[105]

9.5. Side-effects related to Obesity

In a study on rats, sympathetic activation from circulating fatty acids (commonly seen in obesity) is reduced via curcumin’s lipid lowering effects; the resulting state is cardioprotective independent of weight loss.[119]

Curcumin can also suppress angiogenesis in rat fat cells, a longer term adaptation associated with prolonged obesity.[120] This is a general mechanism that applies to more cell types as well.[121]

10. Oxidation and Anti-Oxidation

When comparing 500mg curcumin against 6g curcumin, the anti-oxidative potential of the two does not significantly differ; if anything, 500mg curcumin seems superior due to insignificantly higher AUC of the increase in anti-oxidant abilities as measured by ORAC.[80] This is thought to be due to a possible pro-oxidant effect of curcumin at higher dosages, seen with other anti-oxidants.[122][123]

11. Interactions with Inflammation and Immunology

11.1. Mechanisms

One of curcumin’s most well-researched effects on inflammation is inhibiting TNF-a induced activation and nuclear translocation of nF-kB, a protein that influences the genetic code to produce inflammatory cytokines. This has been seen in immune cells after oral ingestion of 150mg curcumin (Resveratrol at 75mg, Green Tea Catechins at 150mg, and soy at 125mg as confounders)[124] but also in isolation in vitro[125] and in vivo.[126][127][128][129] Activation of nF-kB can increase protein content (amounts) of Cyclooxygenase-2 (COX-2), a pro-inflammatory enzyme; pretreatment with curcumin reduces COX-2 upregulation induced by inflammatory cytokines.[130] Other pro-inflammatory enzymes that are suppressed by curcumin are iNOS, LOX (directly inhibited), and Phospholipase A2 (directly.)[131]

Curcumin appears to be able to suppress most adhesion molecules investigated, including E-selectin and P-selectin, ICAM-1, VCAM-1, and ELAM-1, the latter three are due to nF-kB inhibition downstream of Akt.[132][133]

Curcumin can reduce inflammation through a variety of means; preventing pro-inflammatory signals from acting on the nucleus (nF-kB related), reducing the ability of immune cells to get to sites of inflammation (adhesion related), and reducing the exacerbation of already present inflammation by reducing the activity of inflammatory enzymes (COX2, LOX related).

11.2. Treatment of Arthritis

Curcumin is associated with reducing a variety of inflammatory signals, and a lot of them that are associated with arthritis and inflammatory joints.[134]

When dosed equally (200mg/kg in rats), curcuminoids from turmeric are 4.6-8.3% more effective than the active components of Ginger in suppressing inflammation associated with cytokine release in arthritis.[135] Both herbs are more potent than indomethacin.[135]

12. Bacteria and Viral interactions

12.1. Virus replication

One study found that curcumin was able to suppress replication of the Rift Valley fever virus and its fully virulent form (ZH501) in vitro.[136] A modification to the IKK-? protein (which inhibits I?B? and serves to enhance nF-kB signalling) keeps IKK-? in an active state and exacerbates inflammatory signalling, curcumin can bind to IKK-? and allow I?B? to suppress nF-kB activation and inflammation, which prevents virus replication.[136]

13. Implications in Cancer Metabolism

13.1. General (Not mechanisms)

Curcumin has the ability to protect DNA from oxidation via the heavy metal arsenic[137], and this protection has been demonstrated in human trials after oral ingestion 1g of a 20:1 curcumin:piperine (Black Pepper) combination for 3 months.[138] Blood lymphocytes were the biomarker for DNA damage.

In rats fed a low dose of curcumin (0.03% of the diet), curcumin was able to prevent formation of adducts in hepatic DNA induced by an injection of the carcinogenic benzo(a)pyrene.[139] Curcumin also prevented adducts in colonic cells when administered at 2% of the diet with meals.[140]

13.2. General (Mechanisms)

One of the mechanisms under investigation for chemoprotective effects of curcumin is the inhibitory effect on nF-kB, a protein that can influence genetic coding and transcription when activated. Normally, TNF-a (a pro-inflammatory cytokine) positively influences nF-kB activity and induces cell growth, survival, and inflammation. Curcumin can inhibit the interaction between the two molecules without reducing TNF-a levels, and aside from the inhibition of cytoprotection the elevated levels of TNF-a can induce cellular death via Fas-associated protein cell death and caspase-8.[141] This mechanism appears to ‘sensitize’ cells to cell death induced by TNF-a by inhibiting cellular survival via nF-kB[142][143] and is most likely due to curcumin’s ability to prevent or reduce activation of p38 in the face of other activators.[144][145][146]

Curcumin is also able to suppress a transcription factor associated with nF-kB, the Notch family of proteins; this potentiates the suppressive effects on nF-kB, but Notch-1 overexpression is able to act in reverse and attenuate curcumin’s suppressive effects on nF-kB.[68]

Other notable products downstream of nF-kB that are reduced by curcumin administration are cyclooxygenase-2 (COX-2), cyclin D1, adhesion molecules, MMPs, inducible nitric oxide synthase, Bcl-2, Bcl-xL, and tumor necrosis factor (TNF); most of which are associated with cancer metabolism in some manner.[72][71][130] Curcumin appears to directly inhibit IKK? as the method of reducing nF-kB translocation.[147]

In a B-CLL cell culture, curcumin was able to induce apoptosis with an IC50 of 5.5uM while its effects in healthy mononucleated (non-cancerous) cells were associated with an IC50 of 21.8uM.[125]

13.3. Prostate Cancer

Secondary to inhibiting expression of the cytokines CXCL1 and CXCL2 (a downstream effect of nF-kB translocation inhibition), curcumin appears to negatively regulate several factors that can lead to prostatic tumor meta-stasis (COX2, SPARC and EFEMP) which can lead to less metastasis in vivo.[147] As siRNA inhibition of CXCL1/2 also had these effects, this appears to be the metabolic lever of concern.[147]

14. Interactions with Hormones

14.1. Testosterone

Curcumin, at 100mg/kg bodyweight in rats, has been shown to preserve testosterone levels when coadministered with a drug (Metronidazole) that causes testosterone reductions and worsens parameters of sperm.[148]

Protective effects on the testes have also been noted with curcumin in regards to alcohol, where curcumin (80mg/kg bodyweight) was able to preserve testicle structure and testosterone levels despite alcohol consumption,[149] most likely though preventing the oxidation of ethanol to acetylaldehyde.[150] Other compounds that damage the testicles and reduce testosterone, but are protected against by curcumin, include excessive chromium levels[151] and cadmium.[152]

When looking at the 17beta-HSD3, the final step in testicular testosterone synthesis, curcumin was found to be a noncompetitive inhibitor with an IC50 of 2.3uM, and brought Luteinizing-Hormone stimulated testoterone levels down to 34% of control at a concentration of 10uM.[64] This effect was not dose-dependent, and concentrations of 1uM were not significantly different from 0.1uM and control cells.[64]

Curcumin may also possess inhibitory actions against 5-alpha reductase, the enzyme that converts testosterone into the more potent androgen DHT. The IC50 value is reportedly between 5-10uM.[65]

Given the above two mechanisms (17beta-HSD3 and 5AR inhibition) are anti-androgenic in nature, it would be prudent to observe in vivo effects of curcumin. The only current study on the matter used injections of PEG-curcumin at 0.5mg (giving a Cmax of 7ug/mL to then decline to 1ug/mL) noted a decrease in circulating testosterone levels and function of seminal vesicles, although testicle weight did not decline.[153]

In regards to aromatase, the enzyme that converts testosterone to estrogen (and thus higher activity would mean a more anti-androgenic profile), curcumin does not directly inhibit aromatase in vitro[154] but appears to reduce the catalytic activity of aromatase (also known as CYP1A) in mice.[155] Clinical relevance of these effects is not known.

Curcumin appears to have protective effects on testicular functions, but possesses anti-androgenic activity. The concentration required for inhibition is high, but it appears to occur in vivo when it is met; it is uncertain what oral dose is needed for these effects, but it might occur with superloading and increasing bioavailability. Low doses of curcumin may have no adverse effect whatsoever

14.2. Estrogen

In regards to possible anti-estrogen effects, the lack of inhibition on aromatase[154] but potential to reduce catalytic activity of aromatase[155] suggests some interactions may exist at this stage. One study comparing normal rats versus a Menopausal model (ovariectomized) noted that 10mg/kg oral ingestion in the normal mice was able to reduce circulating estrogen levels.[156]

100nM of Curcumin is able to act as an agonist at estrogen receptors in MCF7 breast cancer cells, but has low activation of target genes relative to estradiol, although more potent than Quercetin and Enterolactone (from Sesamin).[157] It is possible that Curcumin may act as a Selective Estrogen Receptor Modulator (SERM) and compete for the more potent estradiol, as it has been noted to reduce estrogen-induced cell proliferation elsewhere (was not tied directly to the estrogen receptor in this study).[158]

In regards to anti-estrogenic activity, limited but theoretical potential of Curcumin to be antiestrogenic via either reducing the effects of aromatase or via acting as a SERM (not yet wholly established)

A pegylated curcumin derivative (similar bioactivity, designed for ingections) at 500mg in rats is able to exert estrogenic effects as assessed by sex organs (uterine changes indicative of estrogenicity in females).[153]

High doses appear to be estrogenic

15. Interactions with Skeletal Muscle

15.1. Acute Protective Effects

Through it’s anti-oxidant effects, curcumin can ameliorate oxidative damage to skeletal muscle via Ischemia/Reperfusion when preloaded at 100mg/kg (I.P injection) to rats, with a potency greater than Vitamin E.[159] Curcumin also ameliorates the increase in inflammatory cytokines associated with Ischemia/Reperfusion injury.[159][160]

As for the mechanisms of the above, curcucmin (5-10uM) appears to increase Glucose-Regulated Protein 94 (Grp94) expression, which regulates calcium homeostasis; this regulation of calcium homeostasis appears to precede the standard inhibition of nF-kB activation and reduce the state of oxidation when an oxidative insult is produced.[161] Interestingly, curcumin can also inhibit upregulation and damage from lead via preventing Grp94 upregulation,[162] and general protection against cadmium as well.[163]

15.2. Catabolism/Anabolism

Curcumin (via injection) is also implicated in increasing the recovery of skeletal muscle capacity associated with deloading, although it was not able to preserve skeletal muscle mass during deloading.[164] These results differ from earlier ones showing a 100mg/kg oral dose of curcumin in rats was able to reduce muscular atrophy while a higher dose of 250mg/kg actually improved skeletal muscle weight.[165]

Curcumin is able to inhibit Atrogin1/MAFbx and its subsequent ubiquitin ligase activity in vitro at 25uM,[166] which induces skeletal muscle catabolism downstream of p38/MAPK induced by TNF-a. This has been confimed in rats with injections of 10-60ug/kg curcumin daily for 4 days which preserved lean mass in the face of LPS, by preventing p38 activation and the subsequent Atrogin1/MAFbx activation.[166]

15.3. Glucose metabolism

Skeletal muscle, via glucose uptake and oxidation, is a tissue regulator of glucose metabolism.

Some fatty acids, such as palmitic acid, can activate (phosphorylize) IRS-1 which causes negative feedback to the insulin receptor and desensitizes muscle cells to insulin-stimulated glucose uptake; curcumin appears to prevent this from occurring.[167] This effect is shared by Green Tea Catechins.[167] Improvements in this mechanism of insulin resistance have been seen in vivo with dose-dependent oral doses of curcumin at 50, 150, and 250mg/kg bodyweight.[168] AMPK activation appears to be a key intermediate in these effects.[168][102] Beyond acting upon IRS, curcumin may also increase glucose uptake into skeletal muscles by acting on muscarinic acetylcholine receptors and then through PLC and PI3K.[169]

Curcumin has been implicated in reversing some abberations in skeletal muscle associated with type II diabetes, such as upregulation of beta-adrenergic receptors and Akt,[170] the downregulation of NRF2 and Heme Oxygenase-1,[171] and downregulation of AMPK and CPT-1.[168] At least one study has suggested that the state of diabetes may be a prerequisite, and although it didn’t measure all above parameters it did note no effects of curcumin in non-diabetic mice.[172]

16. Interactions with other Organ Systems

16.1. Liver

Curcumin appears to be able to reduce diet-induced liver fat builded (steatohepatitis) at 0.15% of the diet which is thought to be secondary to activation of AMPK and induction of PPAR?.[173]

16.2. Kidneys

At least one human intervention showed that curcumin was able to suppress diabetic nephropathy (related to kidney function) and decrease proteinuria at a dose of 500mg turmeric (22.1mg curcumin) thrice a day with meals for 2 months. The mechanism of action appears to be suppressing pro-inflammatory cytokines like TGF-b and IL-8. These benefits have been shown to extend to nephritis associated with lupus at the same dosing protocol in humans.

Curcumin exerts this apparent kidney protection via suppressing inflammation and related cytokines or mRNA associated with inflammation (MCP-1, IL-8, nF-kB). Curcumin at 5mg/kg bodyweight (rats) is able to prevent histological changes (related to macrophage infiltration) in kidney structure associated with experimental LPS injections when administered simultaneously and in delaying the inevitable progression of renal failure.

Some protective changes are also present, as curcumin can upregulate Heme-Oxygenase 1 in kidney cells partially via nF-kB suppression and this mechanism is linked to kidney protection effects.

Demonstrated to have protective effects on the kidneys in clinical settings, and animal studies suggest this may extend to preventative measures as well

17. Nutrient-Nutrient Interactions

17.1. Piperine

Pairing Curcumin with Piperine, a Black Pepper extract that is also an inhibitor of glucuronidation enzymes in the intestines and liver, is able to increase bioavailability 20-fold (2000% of baseline values) when 20mg piperine is paired with 2g curcumin.

The pairing of the two has been demonstrated synergistic in attenuating benzo(a)pyrene toxicity in various tissues[179][180] as well as mitigating DNA damage.

Interestingly, this synergism does not seem to apply to preventing hypertension induced by L-NAME; both compounds are effective in attenuating high blood pressure from a lack of Nitric Oxide, but their effects are not even additive.

17.2. Ginger

Ginger and Turmeric are both plants in the same family of plants, and may have related phytonutrient profiles due to this association.

One study investigating the combination of 6-gingerol enhanced ginger and turmeric topical solution (at 3% and 10% respectively) found enhanced wound healing with both compounds in isolation and slightly better recovery with the combination, although not synergistic.

The combination appears to be more effective than either compound in isolation in suppressing some adverse blood parameters associated with metabolic syndrome, such as high blood sugar and lipids.

17.3. Soy Isoflavones

The soy isoflavones, particularly genistein and daidzein, appear to be synergistic with curcumin as it pertains to reducing androgen receptor content and circulatin Prostate-Specific Antigen (PSA) levels in otherwise healthy men; insinuating the combination could be useful against prostate cancer. The dosages used were fairly low in this study, 40mg of isoflavones (66% daidzein, 10% genistein) and 100mg curcumin daily for 6 months, and dropped PSA from 18.8+/-12.4 to 10.2+/-6.2ng/mL.

17.4. Docosahexaenoic acid

One component of Fish Oil, docosahexaenoic acid (DHA), exert synergistic effects in anti-cancer signalling in breast cancer cells which is apparently unique when looking at the mechanisms of either compound in isolation. This synergism apparently extends over into each compounds anti-inflammatory effects, and this mechanism extends to EPA.

17.5. Vincristine

Curcumin at 1uM concentration in cancerous leukemia cells has been shown to synergistically enhance the actions of Vincristine, an alkaloid isolated from Madagascar Periwinkle (not to be confused with Vinpocetine, from another species of Periwinkle). This occurred in 4 out of 5 samples when Vincristine was incubated at 10uM.

17.6. Rolipram

Curcumin shows synergism with Rolipram (a potent PDE4 inhibitor); PDE4 inhibitors increase cAMP levels via PKA in cancerous leukemia cells. Additive in 1 out of 5 tested samples and synergistic in the other four.

A nutraceutical PDE4 inhibitor (at the moment, synergism untested) is Resveratrol.

17.7. Iron

A wide variety of phenolic compounds (of which curcumin is one) are able to bind to dietary non-heme iron and inhibit its absorption; this is seen with Green Tea Catechins and Quercetin mostly. Curcumin has been found to interact with some ions after digestion.

When testing for the interaction of turmeric and iron, whole turmeric at 0.5g was found to not adversely affect iron absorption.

17.8. Itself

Curcumin is one of the four curcuminoids, a curcuminoid being defined as a molecule with two ferulic acid moieties bound together. At least one study has looked at the effects of each ingredient in isolation and the combination, and in regards to its nematocidal effects the four curcuminoids show synergism with each other.

17.9. Garcinol

Garcinol is a polyisoprenylated benzophenone chalcone molecule that is found in Garcinia Indica, a plant in the mangosteen family of fruits. It was found synergistic in inducing apoptosis in pancreatic tumor cells with an apparent synergism 2-10 fold higher than the sum of the two.

18. Safety and Toxicology

18.1. General Safety

According to human interventions investigating anti-cancerous effects of curcumin, doses up to 10g daily of curcumin are not associated with any acute or salient signs of toxicity. When using enhanced formulations to increase circulating levels of curcumin, 1g of MERICA (Curcumin bound to lecithin) over 8 months is not associated with any side-effects.

18.2. Side-effects

Dosages of 6g daily have been associated with minor flatulence and a yellowing of the stool, both of which stopped after supplement cessation.

Jiang Xiang – Dalbergia heartwood – “Descending Fragrance”

Nature: acrid, warm

Enters: Heart, Liver, Spleen, Stomach

Actions: Promotes blood and Qi circulation, dispels blood stasis; stops bleeding; relieves pain.

Indications:
• Blood stasis: pain in the chest, hypochondria, pain and bleeding in trauma, fractures, sprains, contusions.
• Spleen and stomach Qi stagnation: epigastric and abdominal pain.
• Topical: for lacerations.
• Coronary heart disease.
• Bensky/Gamble classifies this with herbs that stop bleeding.
HF: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).

Dose: 6-9g (1.5-3g directly as powder)

Liu Ji Nu – Artemisia anomala – Anomala – “Liu’s Resident Slave”

Nature: bitter, warm

Enters: Heart, Spleen

Actions: Dispels blood stasis; unblocks menstruation; alleviates pain.

Indications:
• Blood stasis: amenorrhea, post partum abdominal pain; falls, fractures, contusions, sprains.
• Acute viral hepatitis: icteric or anicteric phase. Rapidly improves the appetite.
• Topical: as a powder/ointment for contusions, bleeding from wounds, and especially burns. In one study, an ointment made from the herb was beneficial in treating all 24 cases of second- and third-degree burns, with healing occurring in three days to three weeks.

Dose: 3-9g

Lu Lu Tong – Sweetgum fruit – Liquidambar – “All Roads Open”

Nature: bitter, neutral

Enters: Liver, Stomach

Actions: Promotes blood and Qi circulation; opens the middle Jiao; unblocks the channels; promotes urination.

Indications:
• Stagnation: Epigastric pain, abdominal distention, irregular, scanty menses.
• Wind-damp Bi syndrome with pain and stiffness of the lumbar region and knees.
• Edema with difficult urination.
• Doctrine of signatures: resembles a pollen grain or mast cell – useful for allergic disorders. Also, Li: its tiny points indicate its ability to guide to small places (sinuses, channels, etc.).
Hsu: Anti-allergic effect, cures urticaria and allergic rhinitis.

Dose: 3-9g

Mao Dong Qing – Ilex root – Rough-haired Holly – Ilex pubescentis

Nature: bitter, astringent, neutral

Enters: Heart

Actions: Clears heat and toxicity; invigorates blood circulation; promotes flow of the channels.

Indications:
• Wind-heat EPI.

• Lung heat: cough, water distention in the larynx, swollen painful throat, tonsillitis.

• An ingredient in the popular patent remedy Gan Mao Ling.
• Dysentery.
• Coronary disease; thrombotic infarction; vasculitis.

• Topical: burns.
• Anti-tussive; bacteriostatic; expectorant; hypotensive; dilates coronary arteries; probably has antiviral properties.
Dose: 30-120g (to 500g for phlebitis)

Meng Chong – Tabanus – Gadfly

Nature: bitter, slightly toxic, slightly cold

Enters: Liver

Actions: Powerfully promotes blood circulation and removes blood stasis.

Indications:
• Blood stasis: amenorrhea, traumatic injury, masses.
• May cause diarrhea (which can be beneficial if there is blood stasis in the intestines).
• This is the strongest herb to promote blood circulation in the pharmacopeia.
Hsu: Anticoagulant and hemolytic effects.

Dose: 1.5-3g

Mo Yao – Myrrh – Commiphora myrrha resin

Nature: bitter, neutral

Enters: Heart, Liver, Spleen

Actions: Promotes blood circulation, dispels blood stasis, relieves pain; relieves swelling; promotes tissue regeneration; relaxes the tendons.

Indications:
• Blood stasis: dysmenorrhea, amenorrhea, epigastric pain, Bi syndrome, traumatic injury, carbuncle pain, appendicitis, immobile abdominal masses, abdominal pain, chest pain, sores, swellings.
• Topical: non-healing carbuncles, ulcers, sores.
• Stomatitis, gingivitis, laryngitis.
• Stronger for severe pain (e.g. angina pectoris) than Ru xiang.
• Better than Ru xiang at removing blood stasis.
• May lower cholesterol and prevent plaque.
• Stimulates gastrointestinal motility.
• Antifungal.
• Fry with vinegar to enhance its blood circulating properties.
• Related to the Ayurvedic herb Guggul.
JC: Tonic, stimulant, powerful antiseptic and disinfectant (mucus membranes), vulnerary (healing), expectorant, emmenagogue, astringent, carminative, purgative (large dose), cardiac stimulant.
• Increases WBC count.
• Enhances the eliminative function of the mucus membranes of the bronchi and genitourinary tract.
DY: The uncooked herb is irritating to the stomach and mucus membranes.
Yoga: Bola: K, V-; P+ (in excess)
• Bitter, astringent, sweet/heating/pungent.
• Alterative, emmenagogue, astringent, expectorant, antispasmodic, rejuvenative, analgesic, antiseptic; prevents decay, reverses aging, rejuvenates the mind and body.
• Closely related to Guggul (Commiphora mukul).
• Dispels old, stagnant blood from the uterus.
K&R: Anti-inflammatory, astringent, immune stimulant, epitheliogenic.
• Metal: clears phlegm from the mucus membranes.
• For bronchitis, urinary tract infections, pharyngitis, gingivitis, skin ulcers.
• Increases WBC count.
PCBDP: Lowers lipids, cholesterol; inhibits platelet aggregation; appears to activate the thyroid gland (animal studies).
IBIS: Anticatarrhal, antimicrobial, antiseptic, astringent, carminative, expectorant, stimulant.
• [Western] Dosage: tincture: 2 – 5 mL.
• Mucous membranes pale and lax; tonsils enlarged and spongy; throat pale and tumid; chronic bronchitis with profuse secretion of mucus or muco-pus, difficult to expectorate; soreness and sponginess of gums; ptyalism; weight and dragging in pelvis in females; leukorrhea; muscular debility (Felter and Scudder, p. 483)
• External: spongy and bleeding gums; sore throat with aphthous or sloughing ulcers; chronic pharyngitis with tumid, pallid membranes and elongated uvula; spongy, enlarged tonsils (Felter and Scudder, p. 483)
• Internal: enfeebled conditions with excessive mucous secretion, especially in the bronchial and renal mucosa; chronic bronchitis; chronic gastritis; atonic dyspepsia (Felter and Scudder, p. 483); pharyngitis; respiratory catarrh; common cold; furunculosis; mouth ulcers; gingivitis (British Herbal Pharmacopoeia, p. 73)
• Contraindicated during pregnancy (Felter and Lloyd, p. 1300) due to its emmenagogue and abortifacient effects (Brinker, Farnsworth)

Dose: 3-12g

 
BII (Guggulipid, from Guggul, Commiphora mukul): Lowers cholesterol and triglycerides – cholesterol typically will drop 14-27% in 4-12 weeks while triglycerides will drop 22-30%.
• Increases the liver’s metabolism of LDL and uptake of LDL from blood.
• Standard dosage is 25 mg of guggulsterone [a component] TID.
• Non-toxic, safe in pregnancy.
• Beneficial in acne vulgaris.
• May inhibit platelet aggregation.
• Useful in atherosclerosis, however the high dosage required of the crude herb or extracts can lead to side effects and therefore pure guggulipid (guggulsterone) should be used.

Chuan Niu Xi – Cyathula root – “Sichuan Ox Knee”

Nature: sweet, bitter, neutral

Enters: Liver, Kidney

Actions: Expels wind; promotes urination, drains dampness; invigorates the channels and blood; disperses blood stasis; directs fire and blood downward; weakly nourishes the liver and kidneys.

 

Indications:
• Stronger to move blood and alleviate pain, but less tonifying than Huai niu xi.
• Pain due to wind-dampness – especially lower back pain.
• Musculoskeletal pain, traumatic injury.
• Atrophy and spasm in the lower extremities.
• Painful urination with blood in the urine.
• Amenorrhea, postpartum abdominal pain, difficult labor, abdominal masses.
• Hematemesis, epistaxis, toothache, ulcers on the tongue and mouth, headache and dizziness associated with fire flaring upward and abnormal bleeding.

Dose: 4.5-9g

Huai Niu Xi – Achyranthes root – “Ox Knee”

Nature: bitter, sour, neutral

Enters: Liver, Kidney

Actions: Promotes blood circulation, dispels blood stasis; tonifies the liver and kidneys; strengthens the sinews and bones, benefit the joints; promotes urination; conducts blood, fire/heat/Yang, and herbs downward; clears damp-heat in the lower Jiao; unblocks the menses.

Indications:
• Blood stasis: irregular menstruation, dysmenorrhea, amenorrhea, abdominal pain after childbirth, traumatic injury, lochioschesis.
• Liver and kidney deficiency: weak, sore lower back, and lower limbs (knees).
• Liver Yang rising, upper body bleeding, or flare-up of fire: hematemesis, epistaxis, toothache, mouth sores, headache, dizziness, bleeding gums, blurred vision.
• Lower Jiao damp-heat: knee pain, lower back damp Bi syndrome, painful urinary dysfunction, vaginal discharge, stones, hematuria.
• Lower Jiao blood stasis (damp-heat): urethral pain, hematuria.
• In its raw form, it is better at promoting blood circulation.
• When it is cooked, it is more tonic. In its raw form it is more blood-moving.
• Lowers blood pressure – sometimes used in very high doses for this purpose.
Hsu: Analgesic, antispasmodic (GI), diuretic, hypotensive (temporary vasodilation), anti-allergic action

Dose: 9-15g

Ru Xiang – Frankincense – Mastic – Boswellia carterii – “Fragrant Milk”

Nature: bitter, acrid, warm

Enters: Heart, Liver, Spleen

Actions: Promotes blood and Qi circulation; relieves pain; relieves swelling; promotes tissue regeneration; relaxes the sinews, invigorates the channels.

Indications:
• Blood stasis: dysmenorrhea, amenorrhea, epigastric, chest, abdominal pain, Bi syndrome, traumatic injury, carbuncle pain, appendicitis, early stages of carbuncles, sores, swellings, wind-damp Bi syndrome, rigidity, spasms, angina pectoris. Often used with Mo yao (in studies, for chest pain).
• Pain, redness, swelling of the gums, mouth, and throat.
• Topical: as powder or ointment to reduce swelling, generate flesh, alleviate pain, and promote healing of non-healing carbuncles, ulcers, and traumatic injuries.
• Can easily exhaust the Qi.
• Better than Mo yao at relaxing the tendons.
• Fry with vinegar to enhance its blood circulating properties.
Hsu: Strong antibacterial properties.
DY: The uncooked herb is irritating to the stomach and mucus membranes.
Ru xiang is superior to Mo yao for simultaneously moving Qi and blood and freeing the flow of the network vessels to treat Bi with loss of articular mobility and contracture of the sinews.

 

Dose: 3-9g

BII: on a constituent, boswellic acids:
• Osteoarthritis: several mechanisms of anti-arthritic action, including inhibition of inflammatory mediators, prevention of decreased glycosaminoglycan synthesis, and improved blood supply to joint tissues.
400mg boswellic acids TID

Examine.com: On Boswellia serrata (the Indian species – though probably there is a lot of overlap, and I think much of this article is not at all specific to the serrata species):

Boswellia Serrata is a gum resin extracted from a tree, which is sometimes burnt (the entire species of Boswellia is commonly known as Frankinsence) as an aromatic or otherwise administered as medicine. It has most usage for medicine in Ayurvedic medicine, some reading into Traditional Chinese Medicine, and its usage extends to the Middle East and other tropical regions.

Boswellia Serrata, via its active boswellic acids, appears to be a novel inhibitory of a pro-inflammatory enzyme called 5-Lipoxygenase and may possess other anti-inflammatory effects (such as nF-kB inhibition, which are not as novel). These anti-inflammatory effects have been investigated for their benefits in osteoarthritis (OA), and it appears that oral Boswellia supplements can suppress pain and immobility associated with OA quite significantly with the effects taking as little as a week to occur. The studies are well conducted, but funded by the producers of the tested supplements. There are limited non-funded interventions with Boswellic for this claim, but they seem to agree with the battery of funded study in effect size.

Remarkably, Boswellia appears to be quite anti-cancer that appears to be more anti-proliferative rather than apoptotic (the latter meaning to induce regulated cell death) since it is a potent inhibitor of angiogenesis and cell invasiveness. There are not a large battery of studies on these claims, but preliminary mouse and rat evidence where the rodents are injected with tumors suggest that Boswellia can potently suppress tumor growth (Pancreatic, Colorectal) and in some cases actually outright prevent tumor growth (Prostatic, Glioma). Boswellia appears to be a very promising anti-cancer herb due to the potency it exhibits in animals, with one study noting this after oral administration (100mg/kg of the main boswellic acid in animals). The potency has been replicated in other cancer cell lines in vitro (including breast, cervical, myeloma and leukemia) but these cancers do not yet have animal interventions yet.

Boswellia appears to be fairly nontoxic, has a history of usage as a phytopharmaceutical for brain edema associated with radiotherapy (a cancer treatment), and the general anti-inflammatory and anti-cancer effects make it a fairly interesting herb relative to others that have subpar evidence.

The anti-inflammatory and anti-cancer benefits appear to be dose-dependent, with the minimal dose that has been seen as effective being 3 doses of 400mg Boswellia Serrata (basic extract) taken daily with meals. If using Boswellia Serrata itself, doses can increase up to 1800mg taken thrice a day, but are usually in the range of 800-1200mg taken thrice a day.

If using the blends of 5-Loxin or Aflapin (concentrated sources of the main bioactive AKBA), oral doses of 100-250mg are taken once a day with a meal.

Preliminary evidence actually denotes that Boswellia’s AKBA can abolish some (but not all) tumors and their proliferation in rodents. Including pancreatic cancer, prostate cancer, and gliomas.

4.3. Neuroinflammation

A controlled study in mice where 1 hour of Ischmia (deprivation of oxygen) was followed by 24 hours of Reperfusion (resupply of oxygen coupled with oxidative damage) had intravenous Incensole Acetate administered at 1, 10, or 50mg/kg during Reperfusion found that the lesions in control were reduced by 22.3%, 57.8%, and 69.6% respectively.[51] Protection from neurological deficit induced by I/R injury followed a similar dose-dependent trend, and the mechanisms were thought to be secondary to anti-inflammation (with 50mg/kg reducing proinflammatory cytokines by 88% (TNF-?), 77% (IL-1?) and 80% (TGF-?) while suppressing nF-kB activity up to 84% at the highest dose and in a dose-dependent manner).[51] This protective effect was acute in nature, as starting intravenous application of Incensole Acetate 6 hours after reperfusion (rather than immediately) attenuated the reduction in infarct size form 77% to 37%.[51]

 

4.4. Edema

Boswellia Serrata gum was assigned the orphan drug status for the reduction of peritumoral edema by the European Medicines Agency (EMA) in 2002, where it goes by (in Europe) the name of H15.[52] A series of case studies in 12 persons with cerebral edema (7 glioblastoma, 2 anaplastic astrocytoma, two low-grade astrocytoma, and one with cerebral metastases from malignant melanoma) either off or on a stable dose of corticosteroids were given 1200mg H15 thrice a day (3600mg total) for 12 weeks was associated with reduced edema in 2/7 tumor bearers but benefitted all patients with edema due to radiotherapy.[52] Out of the 7 patients with tumors, no tumor responded to Boswellia and overall Boswellia was well tolerated.[52] Similar results have supposedly been found in a clinical trial mentioned in some studies,[53] where 30 patients with glioblastoma recieving 1200mg thrice daily Boswellia extract had less peritumoral edema accompanied with a general improvement of well being. The trial (Winking M et al; Boswellic acid as an inhibitor of the perifocal edema in malignant glioma in man. Neurooncology 1996) is not located online.

Appears to have limited but promising clinical effectiveness in reducing neural edema associated with radiotherapy

In a small unblinded study of 4 persons with chronic cluster headaches who also reported disturbed sleep (due to the headaches) given 350-700mg Boswellia Serrata thrice daily (1050-2100mg total) for up to 3 months noted resoluations in nocturnal headaches in all four subjects and an attenuation of overall headache severity and frequency.[54] It should be noted that cluster headaches have edema as a possible sign.[55]

Basically case studies (so not the most statistically sound), but shows promise for cluster headaches

 

4.5. Depression

A constituent of Boswellia known as Incensole (Acetate) appears to have anti-depressant effects in the Forced Swim Test in mice when injected with 50mg/kg acutely[8] and is effective at 10mg/kg in submissive mice.[12] Lower doses appear effective over time, with 1-5mg/kg in the submissive mice (10-50% acute dose) having similar effects after 1 week of ingestion.[12]

When 10mg/kg in submissive mice was compared to Paroxetine at 10mg/kg, it was technically not statistically different although underperformed,[12] while in normal mice given 50mg/kg it was less effective than 5mg/kg Diazepam in a Forced Swim Test.[8] Anti-depressant effects of Incensole Acetate may be mediated by TRPV3 receptors, as mice lacking these receptors do not have anti-depressant effects in response to injected Incensole.[8]

 

4.6. Anxiety

A constitient of Boswellia known as Incensole Acetate has failed to significantly influence anxiety at the same dose required to exert anti-depressive effects, 10mg/kg in submissive mice.[12] A reduction in anxiety has been seen at 50mg/kg in otherwise healthy mice as assessed by an elevated plus maze (with comparable effects to Diazepam).[8]

Anxiolytic effects of Incensole Acetate may be mediated by TRPV3 receptors, as mice lacking these receptors do not have anxiolytic effects in response to injected Incensole.[8]

 

4.7. Locomotion

A constitient of Boswellia known as Incensole Acetate has failed to significantly influence locotmotion at the same dose required to exert anti-depressive effects.[12] A reduction in locomotion has been noted in otherwise healthy mice given 50mg/kg Incensole.[8]

 

4.8. Cognition

One study using Boswellia papyrifera (similar assortment of bioactives, but may not apply to Serrata) as a 300mg/kg ethanolic extract orally thrice a day (900mg/kg total dose) for 4 weeks showed significant reductions in escape latency and travel distance in a water platform finding test; suggesting improved spatial memory formation.[56] These effects were also seen with isolated Boswellic Acids, and 300mg/kg Boswellic acids thrice a day (900mg/kg) was as effective at enhancing spatial memory formation as the active control of Nicotine (as tartrate salt; 1mcg infusion into the brain daily) although 100mg/kg thrice a day (300mg/kg) was also effective.[56]

 

5. Cardiovascular Health

 

5.1. Platelets

8 hours after consumption of 800mg Boswellia Serrata, there appears to be reduced collagen and arachidonic acid-induced blood clotting in otherwise healthy persons with no effect on Thrombin formation;[43] this was attributed to inhibition of cathepsin G,[41] but was deemed to be weak when compared to Naproxen.[43]

 

5.2. Immunology

Endothelial cells respond to TNF-? (a pro-inflammatory cytokine), and 22% of the genes influenced by TNF-? (n=552) are influenced by Boswellic Acids,[22] particularly those related to proteolysis, cell adhesion, and inflammation.[57] Three metalloproteins (MMP-3, 10, and 11) are potently suppressed in HMECs (endothelial cells) with incubation of Boswellic acids, with more potency being derived from a mixture with a higher concentration of 3-O-Acetyl-11-keto-?-Boswellic Acid (AKBA) where TNF-? induced MMP release was almost abolished.[22] These effects may underlie the protection seen with AKBA in ApoE-/- mice, where 100umol/kg injections of AKBA halved the size of lesions induced by LPS, a proinflammatory molecule[58] and to explain a reduction in TNF-? induced ICAM-1 secretion in vitro (ICAM-1 being an adhesion factor).[59] It should be noted that the direct sequestering of LPS applies to ?-Boswellic Acid and not AKBA, and cannot explain these observed results.[58]

The anti-inflammatory effects of AKBA may be cardioprotective by reducing inflammation and artherosclerosis; this has been seen in vivo after injections, but practical significant of oral ingestion is not known (AKBA tends to have low oral absorption)

 

6. Fat Mass and Obesity

 

6.1. Warmth

A component of Boswellia known as Incensole (Acetate) appears to actiate TRPV3, a receptor upon which activation induces the sensation of warmth;[8] this is a mechanism similar to Evodia rutaecarpa, and the sensation of warmth may create a false positive for fat loss (despite no energy being expended to produce heat, but merely a sensory change).

Warmth from Boswellia Serrata (currently not demonstrated to be an effect) may be a false positive for fat loss due to having the ability to act on a receptor class that induces the sensation of warmth independent of fat burning

 

7. Skeleton and Bone Health

 

7.1. Osteoclasts

A protein known as RANKL is able to induce osteoclastogenesis via activating nF-kB[60][61] and boswellia serrata (via AKBA) can suppress RANKL-induced osteclastogenesis secondary to nF-kB inhibition at a concentration as low as 300nM (75% inhibition in vitro); AKBA also prevented TNF-? from activating nF-kB (3?M).[24] It does not appear to directly interfere with the TNF-? induced nF-kB complexation, but interferes with the genomic transcription of nF-kB.[24]

Boswellia serrata (via nF-kB inhibition from AKBA) appears to hinder the proliferation of osteoclasts

 

7.2. Mechanisms

In human chondrocytes (joint cells), Boswellia with 30% AKBA is able to suppress the TNF-? induced release of MMP-3 with an IC50 of 31.71ug/mL;[59] thought to be relevant to osteoarthritis pathology.

 

7.3. Osteoarthritis

Boswellia Serrata is thought to aid the pathology of Osteoarthritis due to being involved in a herbal combination therapy alongside Ashwagandha and Curcuma Longa (source of Curcumin);[62] the same mixture of herbs which has failed to show any benefit to Rheumatoid arthritis.[63]

In a study comparing two treatments against placebo, the first treatment under the brand name of 5-Loxin (100mg of Boswellia Serrata standardized to 30mg AKBA) was compared to another formulation of Boswellia (Aflapin at 100mg) in 60 persons with confirmed osteoarthritis;[59] the results over 90 days suggested that 5-Loxin reduced symptoms of osteroarthritis on several rating scales by 31.6% (Visual Analogue Scale), 30.3% (WOMAC; pain subset), 42.2% (WOMAC; stiffness subset), 21.25% (WOMAC; functionality subset), and 18.35% (Lequesne’s Functional Index) although the Aflapin group outperformed on all parameters. Both groups reported statistically significant improvements within a week of treatment (around 8% reduction with 5-Loxin)[59] with another study noting improvements by day 5 on VAS and LFI rating scales but not WOMAC[64] and a third study suggesting that the improvements within a week occur with higher (250mg) dose of 5-Loxin and take longer with lower (100mg) doses.[65] Overall magnitude of benefits in other studies are improved symptoms of osteoarthritis as assessed by VAS (37.6%), LFI (32%), and WOMAC subsets of pain (40.1%) stiffness (41.3%) and function (38.8%) after 30 days of 100mg Aflapin[64] and reductions in VAS (48.83-65.94%), LFI (23.79-31.34%), WOMAC pain ( 39.61-52.05%) function (49.34%) and stiffness (62.22%) over 90 days of either 100mg or 250mg of 5-Loxin; with the more significant improvements associated with the higher oral dose and both the function ( 28.62%) and stiffness (42.5%) with the low dose failing to be statistically significant.[65]

Currently a multitude of well controlled studies with either 5-Loxin or Aflapin (nutraceutical patents of Boswellia Serrata with concentrated AKBA to 30% and 20%, respectively), but all the studies using these formulations procured external funding from the producer of the supplements. It did not appear to have any influence on the results and seem to have been conducted indpendently.

Another study of persons with osteoarthritis noted that 6g of basic plant extract in three doses of 2g alongside meals was able to reduce knee pain 70.96-73.68%, shoulder pain by 83.33%, and absolved spinal pain from baseline; improvements occurred in swelling and joint mobility to similar degrees and improvements were noted in happiness and activity levels secondary to reduced pain.[66] Conclusions from this study are limited due to being unblinded and without control group,[66] and despite the promise of the above studies in potency there may not be sufficient independent evidence for Boswellia Serrata for attenuating general joint pain.[67][68]

Definitely shows a large degree of promise in treating joint pain without adverse effects, but the amount of interventions on the matter are enough to show this promise but not enough to draw conclusive statements on its efficacy for treating joint pain; a highly promising but not fully established nutraceutical

 

8. Inflammation and Immunology

 

8.1. Mechanisms (Enzymatic)

5-Lipoxygenase (5-LOX) is an enzyme that used Arachidonic Acid (omega-6 fatty acid) as a substrate to create pro-inflammatory cytokines such as 5-hydroxyeicosatetraenoic acid (5-HETE) and Leukotriene B4; this 5-LOX/Leukotriene pathway being a pro-inflammatory signalling pathway in the body.[69] 11-keto-?-boswellic acid and 3-O-Acetyl-11-keto-?-boswellic acid are inhibitors of 5-LOX with IC50 values of 2.8uM and 1.5uM respectively,[70][71] and although other Boswellic acids (such as ?-boswellic acid) can inhibit the enzyme partially the 11-keto group appears to enhance potency.[71] The inhibitory potential of Boswellic Acids on 5-LOX is nonredox in nature.[72] Due to the inhibitory potential of these two Boswellic acids in particular on 5-LOX, the 11-keto Boswellic acids are thought to be the most important.

However, serum binding of AKBA to albumin is very high (greater than 95%), and 800mg of Boswellia given to participants failed to influence plasma Leukotriene B4 levels (which should be reduced with oral intake of 5-LOX inhibitors);[44] whether this can be overcome with higher doses traditionally used in interventions is not known.

Boswellic Acids do not appear to greatly inhibit 12-LOX nor Cyclooxygenase (COX) enzymes in vitro, nor do they prevent peroxidation of Arachidonic acid induced by iron or ascorbate.[73][74] One study using platelets, however, did note inhibition on COX1 and 12LOX by 3-O-acetyl-11-keto-?-Boswellic Acid (AKBA) with an IC50 of 6uM in platelets and 32uM in a cell-free assay;[75] with another author suggesting that their unpublished data is in accordance.[76]

The most well known mechanism of action of Boswellia appears to he 5-Lipoxygenase inhibition, and the two most potent bioactives in this regard appear to be the 11-keto Boswellic acids. The 5-LOX inhibition is direct and specific, rather than a general inhibition that can be induced by anti-oxidant compounds; however, whether this mechanism is active in vivo is currently under investigation (with one report suggesting it is unlikely)

No significant interactions with the two Cyclooxygenase enzymes (COX1 and COX2), the targets of NSAID drugs, although some inhibition of COX1 may be possible

Other antiinflammatory mechanisms of Boswellic acid include nF-kB inhibition,[77] which has been noted in vivo in mice given the boswellic acid AKBA in 100umol/kg injections[58][78] and appears to be mediated by multiple mechanisms. In response to Tumor-Necrosis Factor alpha (TNF-?), AKBA appears to bind directly to IKKs and prevent activation of I?B? and p65 (which then prevents induction of nF-kB)[79] and may also directly bind to Lipopolysaccharide (LPS; a bacterial toxin that induces nF-kB).[80] ?-Boswellic acid was able to sequester LPS with an IC50 of 1.8uM, which underperformed the active control of polymyxin B which wholly sequestered LPS at 100nM.[80][81] This appears to be a main mechanism of anti-inflammation, as the reduction of iNOS induction seen in macrophages is wholly due to binding to LPS (with Boswellic acids that do not bind to LPS, such as AKBA, being ineffective).[80] Both studies noted that nF-kB translocation induced by interferons (IFN-?) was unaffected by Boswellic acids.[79][80]

Incensole Acetate in Boswellia species may also inhibit nF-kB activation, as Incensole can inhibit IKK activation loop phosphorylation induced by TAK/TAB and has no inhibitory effect in T-Cells.[82]

General inhibitory effects on nF-kB, a locus for inflammation in response to antigens and dietary stressors; Incensole seems to have novel mechanisms of action, and ?-Boswellic acid appears to bind directly to LPS

Cathepsin G (CatG) inhibition, with ?-Boswellic acid having an IC50 of 0.8umol/L.[41] Cathepsin inhibition is a therapeutic target for antiinflammatory actions in neutrophils (immune cells).[83] AKBA may also be relevant for CatG inhibition as it has an IC50 of 1.2umol/L

Microsomal prostaglandin E2 synthase inhibition has been noted with Boswellic acids,[84] where the IC50 value for ?-Boswellic acid is 5umol/L and the 11-keto Boswellic acids (‘main’ two) appear to be relatively inert following injections into rats.[84] MPE2S inhibition is an antiinflammatory therapeutic target.[85] Additionally, a lupeolic acid (a minor class of compounds in Boswellia Serrata) appears to inhibit Phospholipase A(2) with an IC50 range of 2.3-6.9uM in general and cytoplasmic PLA(2)? at 3.6uM; this inhibits formation of Arachidonic Acid prior to subsequent metabolism by 5-LOX, 12-LOX, or COX-1.[86]

Human Leukocyte Elastase (HLE) is also inhibited by Boswellic acids.[87] HLE is an enzyme released by immune cells (PMNs) and 3-O-Acetyl-11-keto-?-Boswellic acid inhibits HLE with an IC50 of 15?M (7.5ug/mL has also been reported[76]), and in this same study they noted some inhibition with both ?-boswellic acid and Ursolic Acid, but an apparent lack of effect of the structurally related compound 18-?-glycyrrhetinic acid (from Licorice).[87] No other compound in this assay inhibited 5-Lipoxygenase.

Several other direct anti-inflammatory mechanisms exist that are within the physiological ranges observed in pharmacokinetic studies, suggesting that they may be relevant to the actions of Boswellia

 

8.2. Innate Immunity

?-boswellic acid and ?-boswellic acid have been noted to inhibit the guinea pig complement system at 5-100uM (Wagner et al. 1987 in German; cited vicariously through[76]) and have been replicated elsewhere,[88] and this was thought to be secondary to inhibiting C3-convertase in vitro.[88]

 

8.3. Adaptive Immunity (B-Cells and Antibodies)

In a test in mice given sheep erythrocytes (to stimulate humoral immunity), a single dose of 50-200mg/kg Boswellic acids (mixed) induced a dose-dependent reduction of primary hemagglutinating antibody titres when measured 4 days after simultaneous administration of Boswellic acids and the antigen by 10.4–32.8%,[89] Azathioprine at 200mg/kg as an active control reduced hemagglutinating antibody titres by 10.4%.[76]

However, when oral dosing of Boswellic acids were given for 5 days preceding and following exposure to the antigen antibody production was increased by 15.38–26.92% at oral doses of 25-200mg/kg Boswellic acids (with most potency at the lowest dose).[89] This same dose range produced a 37.93–63.79% increase in the primary humoral response when preloaded for 7 days, while the active control of Levamisole (2.5mg/kg) increased the primary response by 25%.[89]

Increased antibody synthesis has also been noted with the polysaccharide fragment in both primary (83.8%) and secondary (79.3%) titres in response to oral ingestion of 10mg/kg polysaccharide, which was more potent than the active control of 2.5mg/kg Levamisole (which was comparable in potency to 1-3mg/kg polysaccharide) over 7-15 days of treatment.[20]

May enhance immunity (antibody response to antigens, or adaptive immunity in response to infection) but this may require constant loading rather than acute loading. A single dose may actually be immunosuppressive

One study conducted in mice given an antigen (hepatitis B surface antigen) using BOS2000 (polysaccharides) as an adjunvant alongside vaccination noted that BOS2000 was able to dose dependently increase the IgA response to the antigen, with 10mcg/mL outperforming 0.5mg/mL aluminum (active control) and doses up to 80mcg increasing the response further.[90]

May augment vaccine efficacy, but no oral studies have been conducted

 

8.4. Lymphocytes

It has previously been noted that in non-immunized mice with no antigen, Boswellic acids have no cumulative effect on Lymphocyte proliferation at 1.95-125ug/mL while acute incubation with Boswellic acids and mitogen stimulating factors (PHA, LPS, Alloantigen, and Concanavalin A) suppress proliferation of lymphocytes.[89] This is in contrast to a study conducted with Boswellia cartenii in heparanized venous blood from participants where acute incubation of different extracts with mitogens (PHA) suggested that T-cell transformation was enhanced with the ethanolic extract (containing Boswellic acids common to both species).[91] This study noted that that TC50 value (concentration of bioactive converting half of lymphocytes to active T-cells) ?-boswellic acid, Acetyl-?-boswellic acid, and Acetyl-?-Boswellic acid were 0.0022uM, 0.005uM, and 0.0029uM respectively. Other compounds that appeared to be active were Lupeol (0.0029uM) and 3-oxo-tirucallic acid (0.011uM) while 1mg/mL of the alcoholic extract overall had a TC50 of 0.55mg/mL and induced 90% conversion at 1mg/mL.[91] These effects were reported to be comparable to Echinacea Purpurea.

Stimulation has been noted with the polysaccharide fragment in response to mitogens at 1, 3, and 10mg/kg with maximal effectiveness at 3mg/kg.[20] This same study noted a proliferation of both CD4 and CD8 positive lymphocytes.[20]

Mixed results in regards to lymphocyte proliferation, but appears to stimulate proliferation (pro-immunity result)

 

8.5. Macrophages

Activation of Macrophages by LPS (may only hold biological relevance when it comes to gut-immunity relations, as LPS is unique to bacteria) can be abolished with direct binding between ?-Boswellic acid and LPS.[80]

Otherwise, phagocytosis of macrophages is enhanced when Boswellic acids are incubated with the macrophages at concentrations of 1.95–125?g/mL, with maximal efficacy at 62.25?g/mL.[89] Enhancement of phagocytosis is also noted in vivo after oral adminsitration of low doses of the polysaccharide component BOS 2000 where 1, 3, and 10mg/kg increased phagocytosis [20] Relative to the active control of 2.5mg/kg Levamisole, 1mg/kg was similarly effective while 3mg/kg was more effective and 10mg/kg outperforming all other groups.[20]

 

8.6. Pancreatic

In a rodent model of toxin-induced Type 1 diabetes (multiple low dose streptozotocin at 40mg/kg), injections of 150mg/kg Boswellia Serrata (5.48% and 4.66% KBA and AKBA) failed to influence blood glucose in otherwise normal mice yet outright abolished the increase of blood glucose in response to the toxin when both were administered fro 5-10 days and measured over 25 subsequent days.[92] Histology between control and the Boswellia group did not appear significantly different from each other, and the serum increase in granulocyte-colony stimulating factor was normalized (with a significant attenuation of GM-CSF) while the levels of IL-1A, IL-1?, and TNF-? were equal between control and Boswellia (attenuation of IL-2, IL-6, and IFN-? that was not equal to control but lesser than disease control group).[92]

Anti-inflammatory effects have potent protective effects against streptozotocin-induced toxic effects to the pancreas, with this rat study literally negating most of the toxic effects of streptozotocin

Read this whole article.

San Leng – Sparganium rhizome (or Scirpus) – “Three Edges”

Nature: bitter, acrid, neutral

Enters: Liver, Spleen

Actions: Strongly promotes blood and Qi circulation, and dispels blood stasis; relieves pain; dissolves accumulations.

Indications:
• Blood stasis: amenorrhea with abdominal pain, post-partum abdominal pain, abdominal masses, dysmenorrhea.
• Food retention and stagnant Qi: (severe) distending pain in the epigastrium and abdomen.
• Often combined with E zhu. Liu says San leng is stronger than E Zhu at promoting Qi circulation, but weaker than E zhu at promoting blood circulation. Bensky/Gamble says just the opposite.
• Used with E zhu in oncology (useful in hepatic carcinoma in one study).
• Kamto: San leng + E zhu is great combination for depression.
HF: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).
DY: With E zhu to strongly and effectively break both the Qi and blood, regulate and rectify the Qi and blood, stop pain, and reduce food accumulation. For specific indications and notes on this combination, see E zhu in this category.

Dose: 3-9g

Shui Zhi – Leech – Hirudo

Nature: bitter, salty, slightly toxic, neutral

Enters: Liver, Bladder

Actions: Strongly dispels blood stasis; reduces immobile masses.

Indications:
• Blood stasis: amenorrhea, traumatic injury, masses.
• Wind-stroke.
• Hypercholesterolemia.
• Coronary heart disease.
Shui zhi eyedrops are very effective for acute conjunctivitis. (May cause transitory pain upon application, but no other side effects.)
• Hirudin (a component): anticoagulant (especially in ethanol extract) – is denatured by heat. Therefore, the herb should not be cooked long, if at all. Leech extracts (hirudin) are tremendously popular in Chinese hospitals, used for everything Warfarin (Coumadin) is prescribed for.
• Leech secretes a histamine-like substance that acts as a vasodilator.
• Contraindicated in pregnancy.
• Some say the herb should be toasted until yellow, then powdered and taken directly.
• Guohui Liu says: Much stronger than Tu bie chong. Bensky/Gamble say: More moderate than Tu bie chong but with a more sustained effect.
MLT: Hirudin interferes with the clotting effect of thrombin on fibrinogen.

Dose: 1.5-6g

Si Gua Luo – Luffa – Dried skeleton of vegetable sponge – “Net of String Melon”

Nature: sweet, neutral

Enters: Liver, Lung, Stomach

Actions: Expels wind; invigorates the channels; expels phlegm; expels summer-heat; promotes urination; benefits the breasts.

Indications:
• Damp-heat obstruction of the channels and muscles: chest and flank soreness, pain and soreness in the muscles and sinews, stiffness in the joints. Also for traumatic injury.
• Lung heat: cough with high fever, chest pain, and sputum that is difficult to expectorate.
• Summer-heat: fever, scanty urine.
• Swollen, painful breasts; insufficient lactation; breast abscess.
• Antitussive and expectorant (though not as strong as the vine if the same plant).
• Doctrine of signatures: its affinity for the muscles and sinews is reflected in its sinewy, fibrous makeup.

Dose: 6-12g (up to 30g when used alone)

Su Mu – Sappan wood – Caesalpinia sappan

Nature: sweet, salty, slightly acrid, neutral

Enters: Liver, Heart, Spleen

Actions: Promotes blood circulation; dispels blood stasis from the channels; relieves pain; reduces swelling; stops bleeding.

Indications:
• Blood stasis: amenorrhea, abdominal pain after childbirth, pain and swelling of traumatic injury – falls, fractures, contusions, sprains.
• Excessive post-partum bleeding with dizziness, vertigo, and shortness of breath.
• Similar to Hong hua but not often used – usually for fractures and sprains.
• Antibiotic: particularly against staph, salmonella.
• Contraindicated in pregnancy.
Hsu: Analgesic; inhibitory effect on the CNS; tranquilizer – a small dose can induce sleep; shortens blood coagulation time.

Dose: 3-10g

Tao Ren – Peach kernel – Prunus persica (or P. davidiana)

Nature: bitter, neutral

Enters: Liver, Heart, Large Intestine, Lung

Actions: Promotes blood circulation, dispels blood stasis; moistens the large intestine, promotes bowel movement; unblocks the menses.

Indications:
• Blood stasis: dysmenorrhea, abdominal pain after childbirth, traumatic injury, flank pain, Lung abscess, intestinal abscess with immobile abdominal mass.
• Large intestine dryness: constipation.
• Alcohol extractions have a weak anticoagulant effect.
• Traditionally this herb is used with its peel. To promote bowel movement, remove the tip.
• Contraindicated in pregnancy.
• Sometimes double kernels occur (they look like “Siamese twin” kernels) – these are said to be toxic.
Hsu: Anticoagulant, antiphlogistic, detoxicant, laxative.
DY: Tends to dispel blood stasis in the lower part of the body, in the abdomen, and in the organs; very slightly nourishes blood.
• Like Xing ren, Tao ren is slightly toxic. The toxicity is localized in the superficial skin and the tip of the seed. The preparation, scalded Tao ren, eliminates this toxicity. However, in this form, Tao ren is less powerful at quickening the blood and dispelling stasis.
• With Hong hua: Hong hua is stronger than Tao ren at moving blood, while Tao ren is stronger at dispelling stasis. Together, they complement and reinforce each other to effectively quicken the blood, dispel stasis, engender blood, and stop pain. For specific indications and notes on this combination, see Hong hua in this category.

Dose: 4.5-10g

Tu Bie Chong (Di Bie Chong, Zhe Chong) – Eupolyphaga – Wingless Cockroach – “Land Soft-Shelled Turtle”

Nature: salty, slightly toxic, cold

Enters: Liver, Heart, Stomach

Actions: Strongly dispels blood stasis; promotes regeneration of tendons and bones.

Indications:
• Blood stasis: amenorrhea, abdominal pain after childbirth, masses, numb and swollen tongue.
• Sprains, fractures, contusions, lacerations.
• Acute lumbar strain: toast, grind and take as a powder (1-1.5g).
• Coronary artery disease
• For numb and swollen tongue, grind 6g herb with 3g table salt and apply directly.
• Usually ground and put into a tea bag (will float otherwise).
• Soak in wine and then dry-fry to enhance the herb’s effect.
• Contraindicated in pregnancy.
• Liu: Weaker than Shui zhi. Bensky/Gamble: More intense but shorter-acting than Shui zhi. Tu bie chong is used more for treating channel-level problems. The two herbs are often used together.
• Kamto: Ideal for stroke ““ guides to brain. (This is the large, winged cockroach actually)
HF: For cancer: (doctrine of signatures) cockroaches go where the nastiest stuff is and eat it.

Dose: 3-6g

Wang Bu Liu Xing – Vaccaria seed – (Ficus pumila, Hypericum sampsoni, and Vicia sativa also used as substitutes, each with unique properties) – “King Who Does Not Stay But Departs”

Nature: bitter, neutral

Enters: Liver, Stomach

Actions: Promotes blood circulation, invigorates the channels; dispels blood stasis; reduces swelling; promotes lactation; unblocks menstruation; slightly promotes urination.

Indications:
• Blood stasis: dysmenorrhea, amenorrhea; galactostasis after childbirth, mastitis.
• Swellings: benign prostatic hypertrophy/prostatitis, testes, breasts.
• Topical: herpes zoster (shingles) – use a paste of the toasted, powdered seeds mixed with sesame oil. Apply locally once or twice a day and leave on for (at least) 30 minutes. Avoid open sores.
• Used as ear seeds, particularly for the treatment of gall stones.
• Stimulates the uterus.
• Pound before decocting or fry until it pops like popcorn.

Dose: 3-30g

Wu Ling Zhi – Flying Squirrel feces (Pteromys or Trogopterus) – “Fat of the Five Spirits”

Nature: bitter, sweet, warm

Enters: Liver, Spleen

Actions: Promotes blood circulation; relieves pain; dispels blood stasis; stops bleeding.

Indications:
• Blood stasis: pain – dysmenorrhea, abdominal pain after childbirth, chest, epigastric, or abdominal pain; lochioschesis, amenorrhea, uterine bleeding.
• Childhood nutritional impairment with focal distention.
• Often combined with Pu huang in Shi Xiao San for pain (usually dysmenorrhea with bleeding).
• Dry fry the herb to stop bleeding.
• Vinegar fry it to enhance its blood circulating properties.
• Often decocted in cheesecloth or a tea bag.
• Bat (Pteropus) feces is sometimes used as this herb.
CHA: Heiko Lade, 3-19-01: No one in China has used the correct Wu ling zhi for about 20 years because the habitats where flying squirrels used to live are virtually non-existent now, and it is almost an extinct species. Instead they use the feces of a wild field rat.
MLT: For fibroids, uterine or ovarian cysts, tumors.
Hsu: Analgesic – relaxes spasm of smooth muscle; antibacterial (tuberculosis), antifungal.

Dose: 3-10g

Yan Hu Suo – Corydalis rhizome

Nature: acrid, bitter, warm

Enters: Heart, Liver, Spleen, Stomach, Lung

Actions: Promotes blood and Qi circulation, relieves pain.

Indications:
• Blood and Qi stagnation: pain – chest, abdomen, epigastrium, limbs, hernial, trauma, and especially dysmenorrhea. This is the premier analgesic herb.
• Can be used for any kind of pain when combined appropriately.
• Treats ulcers.
• Possesses 1% the analgesic strength of opium.
• Some hypnotic effects; used to promote sleep for insomnia.
• Toast or fry in vinegar to enhance its blood circulating properties.
• Use as a powder for a stronger effect.
Jin: Focuses on the liver.
RW: Greatly reduces the tremors of Parkinson’s disease, chorea minor, and other forms of ataxia.
NAH: Contains the alkaloid bulbocapriine, which has been used for Parkinson’s, Meniere’s, convulsions.
Hsu: Tranquilizer, analgesic, spasmolytic, anti-ulcerative agent.
DY: When used alone or with small amounts of other herbs, use up to 50g in decoction or 10g directly as powder.
• Stops pain in the whole body – the upper and lower, interior and exterior.
• A medicinal for the qi within the blood. It moves the Yang aspect of the blood. It disperses Qi stagnation in the blood and blood stagnation in the Qi. It is, therefore, a medicinal which quickens simultaneously the Qi and blood, but which, nevertheless, has more of its action on the blood than the Qi.
• With Chuan lian zi to clear heat, eliminate dampness, course the liver, move the Qi and blood, and stop pain. This combination (Jin Ling Zi San) is used for indications such as:
– 1. Pain in the chest, epigastrium, abdomen, and lateral costal regions due to liver depression Qi stagnation sometimes associated with liver blood stasis. (Use wine mix-fried Yan hu suo and scorched Chuan lian zi.)
– 2. Liver depression Qi stagnation transforming into liver heat or fire.
– 3. Dysmenorrhea and menstrual irregularities due to Qi and/or blood stasis. (Use scorched Chuan lian zi and vinegar mix-fried Yan hu suo.)
– 4. Heart pain due to Qi and blood stagnation. (Use wine mix-fried Yan hu suo and scorched Chuan lian zi.)
– 5. Inguinal hernia or diseases of the scrotum or testicles due to Qi stagnating in the liver channel. (Use scorched Chuan lian zi and vinegar mix-fried Yan hu suo.)
– 6. Hepatitis, cholecystitis, and angiocholitis due to damp-heat in the liver and gallbladder. (Use scorched Chuan lian zi and vinegar mix-fried Yan hu suo.)
– This combination is a major analgesic which can be added to other prescriptions when pain is a key manifestation of the disorder and especially if this pain is due to Qi stagnation and blood stasis. If there is a headache, add Chuan xiong and Hong hua. If there is chest pain, add Jie geng, Zhi ke, and Xie bai. If there is lateral costal pain, add Chai hu and Yu jin. If there is stomach and epigastric pain, add Mu xiang and Dan shen. If there is lower abdominal pain, add Mu xiang and Tao ren. If there is lower abdomen pain occurring on both sides of the abdomen in the area traversed by the liver channel, add Wu yao and Xiao hui xiang.

Dose: 4.5-12g

Yi Mu Cao – Leonurus heterophyllus – Chinese Motherwort – “Benefit Mother Herb”

Nature: acrid, bitter, slightly cold

Enters: Heart, Liver, Bladder

Actions: Promotes blood circulation, dispels blood stasis; regulates the menses; reduces masses; promotes urination, relieves swelling and edema.

Indications:
• Blood stasis: irregular menstruation, slow flow, amenorrhea with lower abdominal pain, lochioschesis and abdominal pain after childbirth, infertility, immobile abdominal masses, premenstrual abdominal pain.
• Edema with scanty urination, especially with hematuria.
• Acute systemic edema, especially when accompanied by hematuria.
• Damp-heat in the lower Jiao.
• Benign prostatic hypertrophy, prostate cancer, testicular pain.
• Contracts the uterus.
• Opens the coronary arteries, treats coronary artery disease.
• Lowers blood pressure.
• Generally contraindicated in pregnancy.
• The Western (L. cardiaca) and Chinese species appear to be very similar. However, there’s not much in the Chinese literature on its use for heart problems, while this is a central focus of the herb in Western herbal medicine, second only to its OB/GYN uses, and evident by its species name. The Western species has also been attributed calming effects. It may be, as Thomas Avery Garran suggests in his book “Western Herbs According to Traditional Chinese Medicine: A Practitioner’s Guide,” that the Western species is generally therapeutically broader and superior.
MLT: Also for acute and chronic nephritis; postpartum uterine bleeding; incomplete involution of uterus; myocardial infarction: increases circulation to the coronary artery, lowers heart rate, improves microcirculation, prevents platelet agglutination.
• Cook 27g Yi mu cao with 9g Dang gui and take in 3 doses to help restore the womb after childbirth.
K&R: (L. cardiaca) Cardiotonic; stimulates oxytocin; antispasmodic; mild diuretic.
• Fire yin.
• Precordial pain, palpitations, cardiopathy, heart disease.
• Amenorrhea, dysmenorrhea; contracts and clears the uterus postpartum.
• PID – improves circulation in the lower abdomen.
• Relieves edema from nephritis; hematuria from renal calculi.
• Insomnia; goiter; epilepsy.
• Recent use in China as a morning-after contraceptive.
• Lowers blood viscosity and platelet aggregation rate.
• The extract is used for headache, insomnia, vertigo, peripheral circulatory paresthesias.
JC: (L. cardiaca) Emmenagogue, heart tonic, diaphoretic, tonic, nervine, antispasmodic, aperient, hepatic, diuretic.
• May be the best heart tonic known. Calms and supports the heart and nerves, may be used in large doses. Beneficial as a healing tonic in recovering from debilitating fever where other tonics are inadmissible.
• Chest cold, cramps, pains: foment over affected area and take internally.
• Delayed menstruation: give the syrup in hot water. When normal flow is re-established, take cold as a tonic.
• Influenza, severe colds, low fevers: give as hot as can be taken until the patient perspires freely.
• Acute and chronic heart problems (palpitations, endocarditis, pericarditis, intermittent pulse, etc.), epilepsy, nervous exhaustion, spasms, twitching, chorea, neuralgia, spinal disease, indigestion, liver affections, vaginitis (douche).
PCBDP: Chinese studies show anti-platelet aggregation action, lowers blood lipids, inhibitory effects on pulsating myocardial cells.
RW: (L. cardiaca) Antithyroid: for hyperthyroidism, palpitations, tachycardia.
MW: (L. cardiaca) Doctrine of signatures: has “goose tongue” leaves – a signature for rhythm – for the heart – palpitations.
• Also a good spinal remedy – for spinal irritation.
Hsu: Stimulates the uterus, increases flexibility and tonicity of uterus (much weaker than pituitary hormones); diuretic; hypotensive; antibacterial.
DY: Slightly nourishes blood – just enough to not damage the blood when used to dispel stasis.
• Must be used in relatively high dosage (15-30 or more).

Dose: 9-60g (to 120g for edema in glomerulonephritis)
Chong Wei Zi: the seed
• Sweet, slightly cold.
• Dispels blood stasis, but is also astringent and tonic; cools the liver; brightens the eyes.
• For excessive menstruation/uterine bleeding.
• Liver heat: for red, painful, swollen eyes, pterygium.

Dose: 3-9g

Yu Jin – Curcuma tuber (Curcuma aromatica, but sometimes: C. longa, C. kwangsinensis, C. zedoaria) – “Constrained Metal”

Nature: acrid, bitter, cold

Enters: Heart, Liver, Gallbladder, Lung

Actions: Promotes blood and Qi circulation, dispels blood stasis; promotes circulation of liver Qi; relieves pain; clears heart heat; cools the blood; opens the orifices of the heart; normalizes the function of the gallbladder and relieves jaundice.

Indications:
• Qi or blood stasis which has created heat.
• Liver Qi stagnation and blood stasis: pain in the chest, hypochondria, costal region, and abdomen, irregular menstruation, dysmenorrhea, masses in the abdomen.
• Blockage of the heart by damp-heat: distention in the chest and epigastrium, fuzzy head.
• Blockage of heart by stagnant phlegm and Qi: seizures, mania, mental depression, anxiety, agitation.
• Liver Qi stagnation heat: hematemesis, hematuria, epistaxis during menstrual period.
• Gallbladder disorders: damp-heat, jaundice, gall stones, hepatitis.
• Lung heat.
• Topical and internal: pain related to traumatic injury, chronic sores.
• Viral hepatitis: effective at alleviating pain, treating jaundice, and reducing organomegaly.
• There are two main types of Yu jin: Chuan yu jin (“River Constrained Gold”) is less commonly used, is considered to be milder, and is usually used for patients who are relatively weak; Guang yu jin (“Broad Constrained Gold”) is the more commonly used variety.
• There has been much confusion in the identification of Yu jin vs Jiang huang, and even another Curcuma species, E zhu. Subhuti Dharmananda explains the taxonomy and history in this article.
MLT: Use with Shi chang pu for mental derangement, the effects of intoxicating drugs such as marijuana, and lack of focus.
Hsu: Promotes production and secretion of bile; stimulates motor activities of the stomach; stimulates gastric secretions and appetite.
HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.

Dose: 4.5-9g

Yue Ji Hua – Partially-opened Chinese Tea Rose – Rosa chinensis – “Moon Season Flower”

Nature: sweet, warm

Enters: Liver

Actions: Promotes blood circulation; regulates menstruation; reduces swelling.

Indications:
• Blood stasis: scanty menstruation, amenorrhea, chest pain, abdominal pain and distention.
• Swelling: neck swellings, scrofula.
• With brown sugar: for amenorrhea or scanty menstruation with abdominal pain, emotional stress, and constipation.
Dose: 3-6g

Zang Hong Hua – Xi Hong Hua – Saffron – Crocus sativa stigma

• Similar to Hong hua but much stronger and much more expensive.
• It is used in relatively severe cases, mainly for painful obstruction of the chest.
• Used for depression. Extensive research in Iran (main global producer) looks very promising.
• Topical for acne.
• Regulates menstruation.
• Eases cough and asthmatic breathing.
• Reduces fever and inflammation.
• Not to be confused with Meadow Saffron (Colchicum autumnale) which is toxic.

Dose: 1-3g in decoction or 0.5-1.5g eaten directly

Ze Lan – Lycopus – Bugleweed – “Marsh Orchid”

Nature: acrid, bitter, slightly warm

Enters: Liver, Spleen

Actions: Promotes blood circulation (without damaging Zhen Qi), dispels blood stasis; promotes urination, relieves edema; frees the flow of liver Qi; opens the channels; unblocks the menses.

Indications:
• Blood stasis: irregular menstruation, dysmenorrhea, amenorrhea, abdominal pain during menses and after childbirth, masses in the abdomen, traumatic injury, abscess, pain and swelling, pain in the chest and hypochondria, carbuncles.
• Edema over the face and body, dysuria, particularly post partum.
• Postpartum painful urinary dysfunction.
• Cardiotonic effect.
• Also for prostatitis/benign prostatic hypertrophy.
• Topical: for pain and swelling, traumatic injury, abscesses.
• Very safe herb.
• In some parts of China, Pei lan (Eupatorium) is sometimes used as this herb. (Pei lan does not promote blood circulation.)
HF: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).
K&R: Thyroid inhibitor, pituitary inhibitor (TSH, gonadotropins, prolactin), sympatholytic. Fire yang.
• Tachycardia and arrhythmia especially with hyperthyroidism.
• Hormonal influence to treat various prostate and ovary disorders.
RW: Antithyroid: for milder hyperthyroidism: small doses, takes 3-4 weeks for good effect (mainly helps palpitations). Use with Leonurus.

Dose: 3-15g (up to 30g topically)

Notes on This Category

Commonly combined with:
• A. Herbs that disperse the Lungs and resolve phlegm when there is attack of the Lungs by an EPI.
• B. Herbs that clear heat and resolve phlegm when there is Lung phlegm-heat.
• C. Herbs that clear damp-heat when there is damp-heat in the middle Jiao.
• D. Herbs that warm the interior when there is spleen cold-dampness.
• E. Herbs that promote digestion when there is food retention.
• F. Herbs that tonify spleen Qi when there is spleen Qi deficiency.
• G. Herbs that nourish liver blood and Yin and promote blood circulation when there is liver Qi stagnation.
• Since these herbs disperse Qi and tend to be aromatic and drying, they are generally used with caution for patients with Yin or Qi deficiency.
• Since the dispersing effect of many of these herbs is dependent on their volatile oils, these herbs are generally decocted for no longer than 15 minutes.
• When using Chen pi, Ju hong, Ju He, Qing pi, Zhi shi, Zhi ke, Fo shou, Xiang yuan, and other citrus herbs, remember to consider the possibility of the patient’s having a citrus sensitivity or allergy.
• The term “adjusts the middle Jiao” refers to an herb’s ability to re-establish the proper ascent and descent of Qi by the spleen and stomach.
• Also consider these Qi moving herbs from other categories, as appropriate: An Xi Xiang [Open Orifices], Bai Jie Zi [Resolve Phlegm], Bai Dou Kou [Aromatic Transform Damp], Bing Lang [Kill Parasites], Bo He [Acrid, Cool], Cao Dou Kou [Aromatic Transform Damp], Du Huo [Expel Wind-Damp], E Zhu [Move Blood], Gua Lou Pi [Resolve Phlegm], Hou Po [Aromatic Transform Damp], Jiang Xiang [Move Blood], Lu Lu Tong [Move Blood], Rou Dou Kou [Astringent], Ru Xiang [Move Blood], San Leng [Move Blood], Sha Ren [Aromatic Transform Damp], Yan Hu Suo [Move Blood], Yu Jin [Move Blood], Zi Su Ye [Acrid, Warm Release Exterior].

Chen Pi – Aged Citrus peel (usually Tangerine or Mandarin Orange) – Citrus reticulata, C. tangerina, C. erythrosa – “Aged Peel” – And Related Herbs: Ju Pi (unaged peel), Ju Hong (only the outer red part of the peel), Ju He (citrus seed), Qing Ju Ye (the bluegreen leaf)

Nature: acrid, bitter, warm

Enters: Spleen, Lung, Stomach

Actions: Regulates Qi; adjusts the middle Jiao (acrid lifts the spleen Qi, bitter descends the stomach Qi); dries dampness; resolves phlegm; helps the spleen to transport; relieves the diaphragm; directs Qi downward.

Indications:
• Spleen/stomach Qi stagnation: distention in the epigastrium and abdomen, belching, bloating, fullness, nausea, vomiting. Also used for various other forms of nausea and vomiting.
• Accumulation of dampness in the middle Jiao: distention in the chest, epigastrium, and abdomen, stifling sensation in the chest, poor appetite, fatigue, loose stool, thick and sticky tongue coat. An important Qi-level herb of both the spleen and Lung channels, it is especially appropriate for disorders involving both channels.
• Phlegm-damp in the Lungs: cough with copious sputum, difficulty breathing, stifling sensation in the chest.
• Added to tonics to help keep their rich quality from stagnating the Qi.
• Some effectiveness as a transdermal carrier of other substances.
• Mastitis: Chen pi was used with Gan cao in one study to yield good results in 70% of the cases, usually within 2-3 days. The longer the duration of the mastitis, the less effective the treatment.
Chen pi is aged (cured) to eliminate secondary effects and reinforce its primary actions. Generally, the older the Chen pi, the higher the quality and the more effective.
• Use with caution when there is heat.
• Can be carried to guard against taking on patients’ sicknesses.
• Compared to Qing pi, Chen pi has a more harmonious nature and tends to enter the Qi level of the spleen and Lungs. Its actions are primarily vertical and it is therefore used for both coughing and vomiting. Qing pi, on the other hand, has scattering and unblocking properties that are relatively harsh; it is accordingly prescribed for breaking up Qi stagnation. Its actions are more horizontal and it is therefore used primarily for pain.
DY: Moderately fortifies the spleen; harmonizes the stomach, stops vomiting; rectifies the Qi on the right side of the body; downbears stomach Qi counterflow.
• Three essential therapeutic methods are used to treat phlegm-dampness:
– 1. Transforming and drying existing phlegm or evacuating it through expectoration.
– 2. Moving Qi – if Qi moves with fluidity, phlegm is expelled through expectoration and stagnant dampness, which is the origin of the production of phlegm, is moved and does not accumulate – thus dampness does not congeal into phlegm.
– 3. Supplementing the spleen – to promote the transformation and transportation of water and food, and prevent the accumulation of dampness and the engenderment of phlegm.
Chen pi possesses all three essential functions for the elimination of phlegm-dampness – it transforms phlegm, moves Qi, and fortifies the spleen.
• Zhang Zi-he of the (12th century) Southern Song dynasty, said: “Chen pi is upbearing and floating, goes to the Lungs and spleen, influences the upper (body) and frees the flow.”
Chen pi is often added to formulas which supplement the Qi, blood, or Yin in order to ease the assimilation of rich herbs and to avoid Qi stagnation. It can be systematically added to these types of formulas whenever spleen deficiency is suspected.
• With Ban xia for mutual reinforcement, to fortify the spleen, rectify the Qi, dry dampness, transform phlegm, and stop vomiting. For such indications as:
– 1. Cough due to an accumulation of phlegm-dampness. (Use lime-processed Ban xia.)
– 2. Chest oppression, nausea, and vomiting due to stomach disharmony and phlegm-damp stagnation. (Use ginger-processed Ban xia and stir-fried Chen pi.)
• With He zi to effectively constrain the Lung Qi, rectify the Qi, and increase the voice. For hoarse voice, loss of voice, and chronic cough (deficiency type) with loss of voice and phlegm in the throat. (He zi is contraindicated in cases of phlegm-heat or full patterns.)
• With Qing pi to soothe the liver, regulate the stomach, harmonize the liver and spleen, harmonize the liver and stomach, rectify the Qi, and stop pain. For epigastric and abdominal distention and pain, chest and lateral costal region distention and pain due to disharmony of the liver and spleen, liver and stomach, or a liver depression Qi stagnation. For these indications, uncooked or stir-fried Chen pi and vinegar mix-fried Qing pi should be used. In cases of liver-spleen disharmony, add Bai shao, Chai hu, and Bai zhu. This pair is also sometimes used to treat food accumulation in the stomach, diarrhea with abdominal distention due to liver-spleen disharmony, and premenstrual syndrome due to liver-spleen disharmony.
• With Sang bai pi to clear the Lungs and transform phlegm, rectify the Qi, stop coughing and calm asthma. For cough and asthma due to Lung heat with abundant yellow phlegm.
• With Zhu ru to clear and warm simultaneously, eliminating mixed cold and heat in the stomach. They harmonize the stomach, downbear Qi counterflow, and stop vomiting. The combination can be used in the formula Ju Pi Zhu Ru Tang for indications such as:
– 1. Nausea, vomiting, and epigastric and abdominal distention due to spleen-stomach deficiency mixed with cold and heat. (In actuality, the spleen is deficient and cold or at least benefits from the use of warm ingredients, and the stomach is hot and requires clearing with cold medicinals.)
– 2. Nausea and vomiting during pregnancy.
Ju pi vs. Chen pi: Ju pi is the recent skin, while Chen pi is the aged skin. Ju pi is very drying and acrid, more draining and irritating to the stomach. Chen pi is moderate and more efficient. Chen pi is preferred for use in clinical practice.
Hsu: Stomachic; expectorant; anti-emetic; regulates the intestines; hemostatic – strengthens capillaries; antibacterial; increases blood pressure; stimulates the heart; inhibits GI and uterine activity; slightly inhibits urinary excretion.
HF: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).

Dose: 3-9g

 
Ju Hong: Just the red part of the peel
• Acrid, bitter, warm. Enters the Lung and stomach channels.
• Similar to Chen pi, but more drying and aromatic than Chen pi and less effective at harmonizing the middle and regulating the stomach and spleen.
• Resolves phlegm, dispels wind-cold.
• Primarily used for vomiting, belching, phlegm-damp coughs.
DY: Scatters cold, rectifies the Qi; resolves the exterior; dries dampness, transforms phlegm; disperses food stagnation and distention.
• With Zi wan to effectively dry dampness and transform phlegm without drying the Lungs, rectify the Qi, and stop cough. For indications such as:
– 1. Cough with profuse phlegm and chest oppression due to accumulation of phlegm and Qi stagnating in the Lungs.
– 2. Cough with itchy throat, low grade fever, fear of cold, and profuse phlegm due to wind evils attacking the Lungs.

 
Ju He: The seed
• Liu: Shaped like a testicle: guides to and treats testicular problems.
DY: Moves the Qi; scatters nodulation; stops pain; directed toward the Jueyin channel and the Qi division, directed toward the lower burner, into the kidney channel and treats shan. See Li zhi he in this category for notes on shan.
• With Li zhi he, these two herbs are directed toward the liver channel and especially to the region of the pelvis. They effectively scatter cold and nodulation, and stop pain. For specific indications of this combination, see Li zhi he in this category.

 
Qing Ju Ye: Bluegreen citrus leaf
• Frees liver Qi.

Chen Xiang – Aquilaria sap – Aloeswood – “Sinking Fragrance” or “Fragrant Dense Herb”

Nature: acrid, bitter, warm

Enters: Spleen, Stomach, Kidney

Actions: Regulates Qi, relieves pain; descends stomach Qi, adjusts the middle Jiao; directs rebellious Qi downward, regulates the middle Jiao; warms the kidneys, aids them in grasping the Qi.

Indications:
• Blood stasis or cold obstruction (including from deficiency) with Qi stagnation: distention, pain, or a feeling of pressure in the chest, epigastrium, or abdomen.
• Stomach or spleen cold (including from deficiency): rebellious Qi wheezing, vomiting, hiccups, belching.
• Kidney deficiency: asthma, wheezing, cough with difficulty breathing.
• Particularly useful for stagnation in the lower abdomen.
• The true herb is expensive, very aromatic, precious – do not cook it. It is usually powdered and taken directly.
• Powerfully inhibits M. tuberculosis, Shigella.
• Traditionally, this is not just the wood of this tree, but specifically very old wood, and, some say, wood that has been underwater for many years.
Hsu: Antibacterial – for typhoid, dysentery; analgesic, tranquilizing effects.

Dose: 1.5-3g

Chuan Lian Zi – Melia fruit – Sichuan Pagoda Tree fruit – Sichuan Chinaberry

Nature: bitter, cold, slightly toxic

Enters: Liver, Stomach, Small Intestine, Bladder

Actions: Regulates Qi (especially liver Qi), relieves pain; kills parasites, treats fungal disease; clears heat; dries dampness.

Indications:
• Liver Qi stagnation or liver attacking the stomach: costal, hypochondriac, epigastric, or abdominal pain. Also for hernial disorders. Especially useful when there are heat signs.
• Damp-heat Qi stagnation: epigastric, abdominal, flank, or hernial pain.
• Roundworms, tapeworms: abdominal pain. More effective at treating the pain than killing the parasites.
• Particularly useful for stagnation in the flanks and lower abdomen.
• Topical: for fungal infections on the scalp.
• May irritate the stomach – when given in a large dose for a long time, it injures the mucous membrane of the stomach.
• May cause elevation of liver enzymes.
• Must be broken up before using.
Jin: Safe to use in pregnancy (when indicated). Unlike some herbs in this category, this herb is not especially drying.
Li: When used for excess conditions, it will not irritate the stomach.
• Use as a sitz bath for yeast infections, and as a wash for other fungal diseases.
DY: With Yan hu suo to clear heat, eliminate dampness, course the liver, move the Qi and blood, and stop pain. This combination (Jin Ling Zi San) is used for indications such as:
– 1. Pain in the chest, epigastrium, abdomen, and lateral costal regions due to liver depression Qi stagnation sometimes associated with liver blood stasis. (Use wine mix-fried Yan hu suo and scorched Chuan lian zi.)
– 2. Liver depression Qi stagnation transforming into liver heat or fire.
– 3. Dysmenorrhea and menstrual irregularities due to Qi and/or blood stasis. (Use scorched Chuan lian zi and vinegar mix-fried Yan hu suo.)
– 4. Heart pain due to Qi and blood stagnation. (Use wine mix-fried Yan hu suo and scorched Chuan lian zi.)
– 5. Inguinal hernia or diseases of the scrotum or testicles due to Qi stagnating in the liver channel. (Use scorched Chuan lian zi and vinegar mix-fried Yan hu suo.)
– 6. Hepatitis, cholecystitis, and angiocholitis due to damp-heat in the liver and gallbladder. (Use scorched Chuan lian zi and vinegar mix-fried Yan hu suo.)
– This combination is a major analgesic which can be added to other prescriptions when pain is a key manifestation of the disorder and especially if this pain is due to Qi stagnation and blood stasis. If there is a headache, add Chuan xiong and Hong hua. If there is chest pain, add Jie geng, Zhi ke, and Xie bai. If there is lateral costal pain, add Chai hu and Yu jin. If there is stomach and epigastric pain, add Mu xiang and Dan shen. If there is lower abdominal pain, add Mu xiang and Tao ren. If there is lower abdomen pain occurring on both sides of the abdomen in the area traversed by the liver channel, add Wu yao and Xiao hui xiang.

Dose: 3-9g

Da Fu Pi – Betel husk – Areca peel – “Big Abdomen Peel”

Nature: acrid, slightly warm

Enters: Large Intestine, Small Intestine, Stomach, Spleen

Actions: Promotes the downward movement of Qi; reduces stagnation; expels dampness; promotes urination, reduces edema.

Indications:
• Food stagnation, Qi obstruction: epigastric and abdominal distention, regurgitation of food, belching with acid regurgitation. Especially useful when these disorders are accompanied by constipation.
• Damp stagnation in the stomach and intestines.
• Abdominal distention with edema, especially superficial edema, or the symptoms of food stagnation. Also for damp leg qi.
• Strengthens the contractions and tension of the intestines.

Dose: 6-9g

Fo Shou – Finger Citron – “Buddha Hand”

Nature: acrid, bitter, warm

Enters: Liver, Stomach, Spleen, Lung

Actions: Frees the flow of liver Qi; regulates Qi; adjusts the middle Jiao; resolves phlegm; mildly dries dampness; harmonizes the stomach, strengthens the spleen.

Indications:
• Liver Qi stagnation: costal, hypochondriac, or flank pain, distention in the chest, belching.
• Spleen/stomach Qi stagnation: distention and fullness in the epigastrium and abdomen, epigastric pain, poor appetite, belching, nausea, vomiting.
• Lung phlegm: cough with copious sputum. Especially useful for unrelenting coughs with chest pain. Because its phlegm-resolving function is mild, it is not used in treating the early stages of externally-contracted coughs.
• This herb is strong at moving Qi, but weak at alleviating pain.

Dose: 3-9g

 
Fo Shou Hua: the flower
• Similar properties to the fruit, but milder.
• More effective than the fruit at directing Qi downward.
• Often used for cough and wheezing due to rebellious Lung Qi.

Li Zhi He – Litchee nut (Leechee)

Nature: sweet, astringent, warm

Enters: Stomach, Liver

Actions: Regulates Qi, relieves pain; eliminates cold obstruction (particularly in the liver channel).

Indications:
• Cold obstruction of Qi in the liver channel: lower abdominal, genital, testicular, hernial pain, swelling (also for heat in the liver channel when combined with cold herbs).
• Liver Qi stagnation: epigastric pain; abdominal pain, particularly pre-menstrual or post-partum.
• Guides to the genitalia; can guide herbs to the prostate for prostatitis.
• Ringworm: powder the herb, mix with sesame oil, and apply topically.
• Must be broken up before use.
DY: Moves the Qi and blood; scatters cold; directed toward the Jueyin channel and the blood division; directed toward the lower burner, the kidney channel, and treats shan. (Shan: 1. A generic term for all disease of the scrotum and testicles. 2. Hernias, specifically inguinal hernias. 3. Severe abdominal pain associated with anuria and constipation. “Cold Shan” may indicated either of two pathologies: 1. Severe periumbilical pain and abdominal spasms together with spontaneous cold perspiration, fear of cold, cold limbs, a deep tight pulse, and sometimes, in severe cases, numbness of the limbs and generalized stiffness due to a stagnation and congelation of cold evils in the interior of the abdomen. 2. Scrotal or testicular disease due to stagnation and congelation of cold dampness in the liver channel with pain, contracture, swelling and hardening of the testicles, pain radiating toward the scrotum, worsened by cold, etc.)
• With Ju he, these two herbs are directed toward the liver channel and especially to the region of the pelvis. They effectively scatter cold and nodulation, and stop pain. For the following indications, both herbs should be salt mix-fried, because salt guides the action of these herbs toward the lower burner, toward the pelvis, and toward the kidneys. In addition, salt promotes the softening of nodulations in the treatment of shan.
– 1. Inguinal hernia, swelling and pain of the testicles, and scrotal hernia, all due to cold Qi congealing and stagnating in the liver channel.
– 2. Piercing pain in the pelvis due to Qi stagnation and blood stasis.
– 3. Masses in the pelvis (chronic salpingitis, chronic salpingo-ovaritis, chronic adnexititis, ovarian cysts, endometriosis, and fibroids) due to Qi and blood stagnation.
– 4. Abnormal vaginal discharge due to vacuity cold.
– This combination is used successfully in strangury patterns, particularly for stone strangury and Qi strangury (Qi stagnation type), in order to counteract piercingly painful urination and spasms and contractures in the pelvis. For these indications, the combination is an auxiliary treatment and should be added to other standard formulas that treat strangury.

Dose: 6-15g (24-30g for epigastric pain)

Mei Gui Hua – Young flower of Chinese Rose – Rosa rugosa

Nature: sweet, slightly bitter, warm

Enters: Spleen, Liver

Actions: Promotes Qi circulation, relieves constraint; harmonizes the blood and disperses stasis.

Indications:
• Liver/spleen disharmony: stifling sensation in the chest, pain and distention in the flanks and epigastrium, belching, poor appetite.
• Blood stasis: irregular menstruation, premenstrual breast tenderness, menstrual pain.
• Blood stasis secondary to trauma.
• Antidotes antimony poisoning.
• Often used in medicinal wines and made into pastes.
• Bensky/Gamble: When treating menstrual dysfunction, Xiang fu is preferred when there is scanty bleeding, while Mei gui hua is more ideal for excessive bleeding.
MLT: Used in Ayurveda for depression.

Dose: 1.5-6g

Mu Xiang – Auklandia/Saussurea root or Costus – “Fragrant Wood”

Nature: acrid, bitter, warm

Enters: Stomach, Spleen, Large Intestine, Gallbladder

Actions: Regulates Qi, adjusts the middle Jiao, relieves pain; strengthens the spleen, prevents stagnation (does not tonify Qi); adjusts and regulates stagnant Qi in the intestines.

Indications:
• Qi stagnation in the stomach/spleen and/or intestines (including from food retention): distended epigastrium, borborygmus, lack of appetite, epigastric or abdominal pain, nausea, vomiting, diarrhea or dysentery with tenesmus. Because of its slightly astringent quality, this is a common herb for treating tenesmus.
• Liver or gallbladder Qi stagnation: flank pain, distention, or soreness.
• Damp-heat: distending pain in the costal/hypochondriac region, bitter taste in the mouth, yellowish tongue coat.
• Spleen/stomach Qi deficiency: distended epigastrium, poor appetite, vomiting, diarrhea.
• Often included (as with tonics) to facilitate absorption of rich or heavy substances. Especially useful when the transformative and transportative functions of the spleen are weak.
• Particularly useful for paraumbilical stagnation and stagnation in the upper abdomen.
• The unprepared herb is used for stopping pain, while the prepared form (fried with wheat bran) is better for treating diarrhea.
Some sources say this herb is so aromatic and bitter that it can cause dryness.
• This herb should only be cooked for 5 minutes (or less).
Chuan mu xiang – Vladimiria – is sometimes substituted for Mu xiang. It is similar to Mu xiang, but weaker.
MLT: This herb’s action comes from its volatile oils [which will evaporate from extended exposure to heat], therefore, add it during the last 5 minutes of cooking.
• A small amount helps prevent griping from purgatives.
Hsu: Acts on the vagus nerve – stimulates the large intestine, increases peristalsis, moderates pain and gas in the GI tract; antibacterial properties.
HF: An important herb in anti-Gu therapy to move Qi (xing Qi) and break accumulation (po ji).
DY: Dries dampness; arouses the spleen, disperses food stagnation.
• With Bing lang to move the Qi, disperse food stagnation, and stop pain. For such indications as:
– 1. Lack of appetite, abdominal and epigastric distention and pain aggravated by pressure, difficult defecation or dry stools due to food stagnation in the stomach and intestines. (Bing lang should be stir-fried until scorched.)
– 2. Dysentery or diarrhea with tenesmus and abdominal pain due to Qi stagnation. (Use scorched Bing lang and roasted Mu xiang.)
– 3. Constipation or difficult defecation due to Qi stagnation. (Use scorched Bing lang.)
• With Huang lian to rectify the Qi, drain heat, dry dampness, and treat dysentery. This combination is used in Xiang Lian Wan for indications such as diarrhea, bloody and purulent dysentery, abdominal pain, and tenesmus due to damp-heat and Qi stagnation in the large intestine. Roasted Mu xiang should be used.

Dose: 1.5-9g

Qing Pi – Bluegreen Citrus peel – Immature Chen Pi – “Bluegreen Peel”

Nature: bitter, acrid, warm

Enters: Liver, Gallbladder, Stomach

Actions: Frees the flow of liver Qi (particularly in the lower Jiao); strongly regulates Qi, breaks up stagnant Qi, dissipates clumps; disperses accumulation of pathogens; eliminates food retention; dries dampness, transforms phlegm.

Indications:
• Liver Qi stagnation: pain – costal, hypochondriac, breast, lower abdomen, genital, hernial, flank.
• Food retention: distention, pain, or a stifling sensation in the epigastrium. Can be used for severe cases.
• Stagnant Qi/blood: masses, lumps, liver Qi stagnation surrounding food retention.
• Phlegm-dampness with malarial disorders. Especially useful for breast abscesses with this etiology.
• Raises blood pressure.
• Much stronger than Chen pi.
• Compared to Chen pi, Qing pi has scattering and unblocking properties that are relatively harsh; it is accordingly prescribed for breaking up Qi stagnation. Its actions are more horizontal and it is therefore used primarily for pain. Chen pi, on the other hand, has a more harmonious nature and tends to enter the Qi level of the spleen and Lungs. Its actions are primarily vertical and it is therefore used for both coughing and vomiting.
• Guohui Liu: Compared to Chai hu, which mainly addresses liver Qi stagnation in the upper Jiao and costal region, Qing pi mainly addresses liver Qi stagnation in the lower Jiao (though neither herb’s action is entirely limited to that area).
DY: Sinking, drastic; drains the liver and gallbladder Qi; disperses lump glomus; moves the Qi on the left side of the body.
• Its drastic action of breaking Qi contraindicates its long term use.
• 3g rectifies the Qi, 6g moves the Qi, 9g breaks the Qi.
• Zhang Zi-he of the (12th century) Southern Song dynasty, said: “Qing pi is downbearing and sinking, goes to the liver and gallbladder, influences the lower (body) and drains.”
• In combination with Chen pi to soothe the liver, regulate the stomach, harmonize the liver and spleen, harmonize the liver and stomach, rectify the Qi, and stop pain. See Chen pi in this category for specific indications and notes.
• When Qing pi is small, the whole fruit is used. It is then called Xiao qing pi or Xin qing pi.

Dose: 3-9g

Shi Di – Persimmon (Kaki) calyx

Nature: bitter, astringent, neutral

Enters: Lung, Stomach

Actions: Descends rebellious Qi, eases hiccups and belching.

Indications:
• Stomach Qi rebellion: hiccups, belching. For either hot or cold patterns, depending on the herbs with which it is combined.
DY: With Ding xiang to effectively warm the middle burner and scatter cold, downbear Qi counterflow, and stop hiccups. For indications such as:
– 1. Hiccups due to cold in the stomach.
– 2. Nausea and vomiting due to deficiency cold in the spleen and stomach.
– For these indications, this pair is present in Shi Di Tang. For hiccups, add Chen xiang.

Dose: 6-12g

Tan Xiang – White Sandalwood (heartwood) – Santalum

Nature: acrid, warm

Enters: Lung, Spleen, Stomach

Actions: Regulates Qi, adjusts the middle Jiao; disperses cold, relieves pain.

Indications:
• Cold obstruction, Qi stagnation: chest and abdominal pain.
• Stomach cold: thin, clear, watery vomit.
• Promotes activation of local immune system. Some people hang a small bag of it over the chest to prevent EPI’s.
• Recently used for coronary artery disease.
• Precious and expensive. When used in decoctions, it should be added near the end of cooking, to preserve its aromatic compounds. Often used as a powder. Choose cultivated sandalwood, as the wildcrafted product is endangered.
DY: With Dan shen to regulate and rectify the Qi and blood, move the Qi and blood, free the flow of the network vessels, and stop pain. For the following indications, wine mix-fried Dan shen should be used:
– 1. Chest Bi or impediment, heart diseases with severe cardiac pain due to Qi and blood stasis. If heart blood stasis is severe, add San qi, Hong hua, and Yan hu suo. If Qi stagnation is severe, add Chen xiang and Qing mu xiang. If there is phlegm-damp obstruction in the chest, Gua lou pi, Jie geng, and Zhi ke. If there is chest Yang deficiency, add Xie bai, Gui zhi, and Fu zi. If there is Qi deficiency, add Huang qi, Zhi gan cao, and Ren shen.
– 2. Stomach pain due to Qi and blood stasis.
Yoga: Chandana: P, V-; K or Ama+ (in excess)
• Bitter, sweet, astringent/cooling/sweet.
• Alterative, hemostatic, antiseptic, antibacterial, carminative, sedative, refrigerant.
• Eye diseases, cystitis, urethritis, vaginitis, acute dermatitis, herpes zoster, bronchitis, palpitations, gonorrhea, sunstroke.
• Calms and cools the body and mind; stops sweats; reduces fever.
• Applying the oil on the third eye relieves heat and thirst and is good for fever or overexposure to the sun.
• Helps the awakening of intelligence, special function to help open the third eye, increase devotion, and promote meditation.
• Aids in the transmutation of sexual energy.
• Good for most inflammation; good anti-Pitta herb.
• External: as a paste or oil for infectious sores, ulcers.
Hsu: Diuretic; increases WBC count.

Dose: 3-9g (1.5-3g as powder)

 

The Essential Oil:
K&R: Urinary antiseptic.
• Water: UTI (in deficient patient), impotence, frigidity.
Metal: Chronic bronchitis, tuberculosis, chronic or severe diarrhea.
KAD: An active substance of agreeable odor employed in the treatment of subacute and chronic affections of mucous tissues, particularly gonorrhoea after the active symptoms have been mitigated. Chronic bronchitis, with fetid expectoration, chronic mucous diarrhoea, chronic inflammation of the bladder and pyelitis are also said to be benefitted by it. It occasionally disturbs the gastrointestinal tract, and, like copaiba, which it was introduced to supersede, it will occasion cutaneous eruptions. The dose ranges from 5 to 20 drops, in capsules or emulsion. (Note, this essential oil is often adulterated, due to its expense. Only genuine, steam-distilled oil should ever be taken internally.)
EODR: Anti-tumor, antiviral, immune stimulant
• Cancer, viral infections (herpes simplex – cold sores, herpes zoster, HPV, etc.), acne, wrinkles, scars.
• Enhances deep sleep, may remove negative programming from the cells. High in sesquiterpenes that stimulate the pineal gland and the limbic system of the brain, the center of emotions. Can be grounding and stabilizing.
• Apply 2-4 drops directly on location.

Wu Yao – Lindera root

Nature: acrid, warm

Enters: Lung, Spleen, Kidney, Bladder

Actions: Regulates Qi, relieves pain; warms the kidneys; disperses cold; spreads and unblocks the Qi mechanisms, smooths the flow of Qi, facilitates the middle.

Indications:
• Cold obstruction with Qi stagnation: distention in the chest; costal, hypochondriac, epigastric, abdominal and hernial pain; dysmenorrhea; borborygmus.
• Kidney/bladder yang deficiency cold: frequent urination or incontinence.
• While generally more restricted to cold problems, Wu yao treats a wider area than most herbs – for pain anywhere in the trunk from the genitals to the chest.
• Particularly useful for paraumbilical stagnation and stagnation in the lower abdomen.
MLT: Contains borneol – very penetrating and analgesic.
Hsu: Increases intestinal peristalsis, expels gas.
DY: Its area of pronounced action is the abdomen in general and the lower abdomen in particular. It can guide herbs to this area.
• Warms and scatters cold in the liver and kidney channels.

Dose: 3-9g

Xiang Fu – Cyperus rhizome – Nutgrass – “Aromatic Appendage”

Nature: acrid, slighty bitter, slightly sweet, neutral (some say warm)

Enters: Liver, San Jiao

Actions: Frees the flow of liver Qi; regulates menstruation; relieves pain.

Indications:
• Liver Qi stagnation (including with liver/spleen disharmony): pain – costal, hypochondriac, breast, epigastric, abdominal.
• Liver Qi stagnation: irregular menstruation, dysmenorrhea.
• Any “women’s” Qi stagnation problem.
• Particularly useful for stagnation in the upper abdomen.
Xiang fu’s volatile oils contain an estrogen-like substance.
• Bensky/Gamble: When treating menstrual dysfunction, Xiang fu is preferred when there is scanty bleeding, while Mei gui hua is more ideal for excessive bleeding.
• Frying it in vinegar enhances the herb’s ability to enter the liver channel and alleviate pain.
• Frying it in wine enables it to penetrate all the channels.
Yoga: Musta: pungent, bitter, astringent/cooling/pungent; P, K-; V+ (in excess)
• Stimulant, carminative, astringent, alterative, emmenagogue, antispasmodic, anthelmintic.
• Dispels premenstrual congestion of blood and water, menstrual regulator; especially good for emotional problems of PMS.
• Good digestive stimulant for Pitta-types; liver stimulant.
• Improves absorption in the small intestine; stops diarrhea; useful for gastritis.
• Kills parasites; may help candidiasis.
• Chronic fever.
MLT: Amazonian tribes use it as birth control, maybe because an ergot-like fungus with oxytocic properties grows on the root hairs (especially in the jungle).
Hsu: Analgesic; inhibits contraction of uterus.
DY: With Gao liang jiang to warm the stomach and drain cold, move the Qi, and stop pain. For indications such as pain in the epigastrium alleviated by warmth and pressure, chest and lateral costal distention, and nausea due to cold in the stomach and Qi stagnation. For these indications, the combination is used in Liang Fu Wan. Vinegar mix-fried Xiang fu should be used. In cases of severe cold, a larger dose of Gao liang jiang should be used. In cases of severe Qi stagnation (as evidenced by epigastric distention and pain aggravated by pressure), a greater quantity of Xiang fu should be prescribed.
SD: Cyperus is known in Chinese as xiangfu or xiangfuzi. The term xiang means fragrant, and usually is applied to strong and pleasant fragrances, such as those occurring in culinary spices, perfumes, and incenses. The character fu is the same as that used to describe aconite (fuzi); the term was likely used because the appearance of the cyperus rhizomes, the part used, reminded herbalists of the aconite roots. In much of the rest of the world, cyperus is referred to as nutgrass or purple nutsedge (sedge is a term indicating blade-like leaves and rush-like stems and is often applied to the plants of the entire Cyperaceae family); the nut is the rhizome (or tuber), which forms rounded or elongated balls along a tangle of thin roots.
The plant is considered an invasive weed; it has been called “the world’s worst weed.” The plant requires sun and moist conditions, though it grows in sandy soil (one of the old Chinese names for it was shacao, meaning sand weed), as well as in loamy moist fields and in tropical rainforests. It has a vast growing range, crossing the globe and particularly noted in the Pacific Islands (where its leaves are used for weaving) as well as along coastal regions. It is especially prevalent in southern India, where its essential oil is used in perfumery. As an invasive weed, it is considered troublesome in 92 countries and adversely affects more than 50 crops, including sugar cane, corn, cotton, rice, and many vegetables. Cyperus grows rapidly and fills the soil with its tangle of roots and rhizomes; this one species (C. rotundus) can produce up to 40,000 kg/hectare of underground plant material. In addition to taking up nutrients and physical space, the plant produces sesquiterpenes, accumulating in the rhizomes, which inhibit the growth of other plants.
For medicinal use in China, the underground portion is collected in autumn, cooked for a short time in boiling water or steamed, with the fibrous roots burnt off; the rhizomes are sliced in half down the center, and dried in the sun.
Cyperus, like other plants, has numerous chemical constituents, many of which may show pharmacological activity, but the main active components appear to be the sesquiterpenes. These are aromatic, spicy tasting molecules. Among the main sesquiterpenes identified in cyperus rhizomes thus far are:
alpha-cyperone, beta-selinene, cyperene, cyperotundone, patchoulenone, sugeonol, kobusone, and isokobusone.
Cyperus also contains other terpenes, such as the commonly occurring plant component pinene (a monoterpene), and several derivatives of the sesquiterpenes, such as cyperol, isocyperol, and cyperone.
These active constituents are found in the volatile oil of cyperus rhizomes, which makes up only about 0.5-1% of the dried rhizome; prolonged cooking of the herb will cause loss of some portion of these constituents. Their main pharmacological actions may be antispasmodic and analgesic effects.
APPLICATIONS
Cyperus is considered by many traditional practitioners to be the best Chinese herb for alleviating depression of qi circulation. According to Jiao Shude (1):
Acrid and slightly bitter in flavor and neutral in nature, cyperus is the most commonly used qi-rectifying and depression opening medicinal. It is diffusing in nature and is able to free the qi aspect of the 12 channels and 8 vessels. In older literature, it was said to govern all qi, resolve the six depressions (qi, blood, phlegm, food, damp, and fire), and regulate menstruation. Cyperus is aromatic, acrid, and dissipating. It regulates qi, soothes the liver, and resolves depression. It treats liver qi depression due to inhibited emotions, which manifests in abdominal fullness and distention, rib-side distention and pain, no pleasure in eating, and oppression in the chest with a liking for long exhalation [sighing]…Cyperus moves qi and frees stagnation; when there is free flow, there is no pain. Cyperus is most commonly used for qi stagnation and stomach pain (caused by anger, or stomach pain exacerbated by bad moods…)…. Because cyperus is a qi-moving medicinal that can also enter the blood aspect, it is traditionally called a qi-in-blood medicinal. It rectifies qi and regulates menstruation, and it is effective for signs such as menstrual irregularities, overdue periods, and abdominal pain during menstruation that are due to liver qi depression in emotionally-inhibited women.
The six depressions (liuyu) mentioned for the older literature were discussed by Zhu Danxi (13th Century). These were outlined by Liu Yiren in the 19th Century book Heart Transmission of Medicine (2); the term depression, as used here, refers to stagnation of circulation, rather than the mental condition we think of today, though there may be a mental correlation to the physical disorder:
Danxi said: ‘So long as the qi and blood enjoy harmonious flow, none of the hundreds of diseases can arise. Once they are depressed and suppressed, various diseases are produced.’ In general, depression is part of any disease. If depression endures, it will generate disease, or, if a disease has endured, depression will be generated. Therefore, to treat any disease, one has to take depression into account in the treatment scheme.
There are six categories of depression: qi, blood, dampness, heat, food, and phlegm. Qi depression manifests as chest and rib-side pain and a deep, choppy pulse. Blood depression manifests as lack of strength in the four limbs and ability to take in food, reddish stools, and a deep pulse. Dampness depression manifests as migratory pain around the body or pain in the joints that starts in wet and cold weather, and a deep, thin and moderate pulse. Heat depression manifests as visual distortion, oppression (chest discomfort), reddish urine, and a deep, rapid pulse. Food depression manifests as acid belching, persistent satiety and fullness, and no liking of food….Phlegm depression manifests as panting and fullness arising on movement and a deep, slippery pulse in the inch opening.
Another view of cyperus is presented by Yang Yifan (3):
Cyperus is a very commonly-used herb to regulate the liver qi. It is pungent, sweet, slightly bitter, and warm, and enters the liver and triple burner meridians. Cyperus is an effective and gentle herb for regulating the qi. It is warm and pungent but without a harsh and drying nature. It promotes liver qi movement, but without the possibility of injuring the yin and blood of the liver. It is slightly bitter, so it can reduce the slight liver heat that is generated by liver qi stagnation. The sweetness can soften the liver and moderate the speed of the qi movement. All these characteristics match the pathological changes in the syndrome of the liver qi stagnation. Because it also enters the triple burner meridian, which is the passage of the qi and water, it can effectively spread the qi throughout the entire body. In clinical practice, cyperus is used for treating syndromes and symptoms associated with liver qi stagnation, such as distention in the hypochondria region, feelings of tightness in the chest, irritability, depression, irregular menstruation, dysmenorrhea, distention and pain in the breasts, and infertility. Since cyperus is so effective for regulating the qi, it is regarded in TCM as the chief of all herbs that regulate the qi and the first-line choice for treating gynecological disorders.
USE IN FORMULAS
Cyperus is included in dozens of traditional herb formulas. To help illustrate its contribution, we look to the formulas comprised of just a few ingredients (4). Yueju Wan (Pills to Relieve Stagnancy of All Kinds) was presented by Zhu Danxi as a treatment for the six depressions. It is comprised of just 5 herbs: cyperus, red atractylodes (cangzhu), cnidium (chuanxiong), shen-chu (shenqu), and gardenia (zhizi), in equal proportions, powdered and taken 6-9 grams each time. The formula treats qi stagnation as the primary syndrome (relying on cyperus) with herbs for secondary manifestations: damp accumulation (red atractylodes); blood stagnation (cnidium); food accumulation (shen-chu); and heat stagnation (gardenia); the sixth entity, phlegm, is resolved by clearing damp, food, and heat. Typically, the syndrome involves abdominal fullness and pain, often accompanied by digestive reactions, such as acid regurgitation, indigestion, vomiting, or diarrhea. Yueju Wan may be utilized in cases of liver-gallbladder diseases. An expanded version of this formula is Liuyu Tang, which adds chih-ko (zhike) citrus (chenpi), perilla stem (sugeng), forsythia (lianqiao), scute (huangqin), and licorice (gancao).
Another example is the two herb formula Liang Fu Wan, pills of galanga (liangjiang) and cyperus (xiangfu). The two herbs are used in equal proportion, ground to powder and taken 6 grams each time. Galanga helps treat pain; this simple formula has uses similar to Yueju Wan, but is applied when pain is the primary manifestation of stagnation. A decoction, Xiang Ju Tang, made from equal parts cyperus (xiangfu), aurantium (juhong), and pinellia (banxia), plus a smaller amount of licorice, is also used for abdominal stagnancy, with a focus on symptoms of dull sensation and distention associated with damp accumulation. And a final example would be Zhengqi Tianxiang San (Heavenly Fragrance Powder for Normalizing Qi), made with cyperus as the primary ingredient and smaller amounts of lindera (wuyao), citrus, perilla leaf (zisuye), and dry ginger (ganjiang). This is powdered and taken 3 grams each time; it is particularly recommended for qi stagnation with sense of uprushing qi affecting the chest and for qi stagnation associated with persistent emotional distress. In all these cases, cyperus is combined with herbs having an acrid taste derived from essential oils, enhancing the aromatic qi-regulating aspect of cyperus. Sesquiterpenes are found in citrus materials (e.g., chenpi, juhong, and zhike) and in ginger family plants (e.g., ganjiang and liangjiang). One of the cyperus ingredients, ?-selinene, is also found in red atractylodes (cangzhu).
CYPERUS IN AYURVEDIC MEDICINE
Cyperus rotundus is thought to have originated in India and then spread from there during the past 2,000 years (it first appeared in a Chinese medicine book around 500 A.D.). The rhizome is used in Ayurvedic medicine, usually called musta, mustak, or mustaka, and is mentioned in the ancient Caraka Samhita (ca. 100 A.D.). Its uses in modern Ayurvedic medicine are primarily for treating fevers and digestive system disorders (diarrhea, vomiting, indigestion, etc.). It is also known as an emenagogue (treats delayed menstruation) and an analgesic useful for dysmenorrhea (painful menstruation). Cyperus is considered a diuretic, but it must be combined with other diuretics to yield a desired result in treating urinary disorders. It is classified as being bitter and astringent, light and dry, cold, pungent (aromatic), and pacifying kapha and pitta (5, 6). Cyperus is an ingredient in popular Ayurvedic formulas such as the herbal honey Chyawanprash, and the women’s blood tonic and uterine regulating formula Ashokarishta. It may also be used as a single herb remedy.

Dose: 4.5-12g

Xiang Yuan – Citrus Vilsonii Tanaka

Nature: acrid, slighty bitter, sour, warm

Enters: Liver, Spleen, Lung

Actions: Frees the flow of liver Qi; regulates Qi; adjusts the middle Jiao; resolves phlegm; mildly dries dampness; harmonizes the stomach, strengthens the spleen.

Indications:
• Liver Qi stagnation: costal, hypochondriac, or flank pain, distention in the chest, belching.
• Spleen/stomach Qi stagnation: distention and fullness in the epigastrium and abdomen, epigastric pain, poor appetite, belching, nausea, vomiting.
• Lung phlegm: cough with copious sputum. Especially useful for unrelenting coughs with chest pain.

• Compared to Fo Shou, this herb is milder at moving Qi, but stronger at resolving phlegm.

Dose: 3-9g

Xie Bai – Chinese Chive bulb – Bakeri

Nature: acrid, bitter, warm

Enters: Lung, Stomach, Large Intestine

Actions: Activates Yang/unblocks the Yang Qi; disperses accumulation of cold, phlegm, and dampness; regulates Qi, disperses Qi stagnation, promotes the movement of Qi and blood, and alleviates pain; directs Qi downward.

Indications:
• Obstruction of cold, phlegm, damp in the chest preventing the dissemination and flow of Yang Qi: chest pain, difficulty breathing, stifling sensation in the chest, flank or upper back pain, coughing, wheezing. Also for blood obstructing the heart channel, and such Western presentations as angina and coronary heart disease.
• Stomach Qi stagnation or damp stagnation in the large intestine: dysentery with tenesmus.
• Cold stagnant Qi: epigastric fullness, distention, abdominal pain.
• Do not use long term in cases of peptic ulcers.
DY: Modern research shows this herb lowers serum cholesterol.
• With Gua lou to effectively free the flow of Yang and move the Qi, loosen the chest and clear the Lungs, transform phlegm and scatter nodulation, stop pain, moisten the intestines, and free the flow of the stools. For indications such as:
– 1. Constipation due to fluid dryness of the large intestine and/or Qi stagnation.
– 2. Yin binding constipation. (Constipation due to spleen-kidney Yang deficiency or sometimes due to dryness in the large intestine caused by an essence-blood deficiency with pale lips, white tongue fur, and clear, copious urination.)
– 3. Chest Bi with oppression of the chest and epigastrium, cough, profuse phlegm, piercing pain in the chest radiating toward the back, and shortness of breath due to accumulation of turbid phlegm blocking the Qi and Yang of the chest. (Gua Lou Xie Bai Ban Xia Tang – which can be favorably combined with Er Chen Tang) Use Gua lou which has been stir-fried until scorched.
– 4. Chest Bi and cardiac disease with intense heart pain due to heart Qi and blood stasis and deficiency of heart Yang. (Gua Lou Xie Bai Bai Jiu Tang) For these indications, the combination can be favorably reinforced by adding Dan shen, San qi, Tan xiang, and Gui zhi. The Gua lou should be stir-fried until scorched.

Dose: 4.5-9g (30-60g when used fresh)

Notes on This Category

Commonly combined with:
• A. Acrid, warm herbs that relieve exterior syndromes when there is exogenous cold attack.
• B. Herbs that promote Qi circulation when there is Qi stagnation associated.
• C. Herbs that tonify spleen and/or kidney Yang when there is Yang deficiency of either organ.
• D. Herbs that tonify source Qi when there is Yang collapse.

• These herbs are to be used with caution for patients with heat, Yin deficiency, or in pregnant women.

Bi Ba – Bi Bo – Long Pepper fruit – Pippali

Nature: acrid, hot

Enters: Spleen, Lung, Stomach, Kidney, Large Intestine

Actions: Warms the middle; disperses cold from the stomach and intestines (middle and lower Jiaos); alleviates pain.

Indications:
• Stomach cold: nausea, vomiting, belching, acid regurgitation, rumbling, abdominal pain.
• Topical: as a powder for pain, especially toothache.
• Antibiotic effect.
• Usually taken directly in powder or pill form.
• Contains piperine – used as a carrier to increase absorption of other substances through digestive tract (e.g., curcumin) and slow metabolism of certain drugs.
MLT: Reverses the flow of rebellious Qi.
• The Ayurvedic mixture Trikatu (the main stimulant compound of Ayurveda) consists of equal parts Bi bo, Hu jiao and Gan jiang. Powder the herbs and mix with honey. Take for cold digestion, allergies with clear/whitish discharges, abdominal and other pains caused by cold.
Yoga: Pippali: V, K-; P+
• Stimulant (digestive and respiratory systems), expectorant, carminative, aphrodisiac, anthelmintic, analgesic.
• Colds, coughs, asthma, bronchitis, laryngitis, arthritis, rheumatism, gout, dyspepsia, abdominal distention, flatulence, abdominal tumors, lumbar pain, sciatica, epilepsy, paralysis, worms.
• Strongly heating, dispels cold, congestion, and Ama, revives weakened organ functions.
• Unlike black pepper, it is a rejuvenative, mainly for the lungs and for Kapha.
• Use as a milk decoction for degenerative lung diseases like asthma.
• Strengthens reproductive functions.
• Take 3 pods with a little honey each morning to control excess secretions, mucus, and Kapha.
Trikatu (mentioned in MLT above) rejuvenates Agni, burns away Ama, allows for the assimilation of other medicines and foods.
Hsu: Analgesic, stomachic, antibacterial.

Dose: 1.5-4.5g (usually taken directly as a powder or pill)

Chuan Jiao – Hua Jiao – Szechuan Pepper fruit – Chinese Prickly Ash – Zanthoxylum bungeanum

Nature: acrid, hot, slightly toxic

Enters: Spleen, Stomach, Kidney

Actions: Warms the middle Jiao, disperses cold, relieves pain; kills parasites.

Indications:
• Yang deficiency with cold in the spleen and stomach: epigastric and abdominal pain, vomiting, diarrhea.
• Roundworms: abdominal pain, vomiting.
• Pinworms: can be used as an enema.
• Schistosomiasis: Chuan jiao can be useful, increases appetite, reduces organomegaly. (Given in capsules in study.)
• Topical: as a poultice or compress for pain.
• Can reduce or stop lactation within 1 or 2 days postpartum.
• Overdose can cause paralysis of the diaphragm.
• Good quality Chuan jiao should cause numbness of the lips when eaten.
• Not to be combined with Li lu. Not to be used for Yang rising headaches.
• Farong Zhang: The seed inside ““ Jiao mu ““ is safe; its toxicity is in the fleshy covering.
Yoga: Tamburu: V, K-; P+
• Powerfully destroys toxins (Ama), kills worms and candida.
• Good for Sama Vata and arthritis; anti-rheumatic, increases peripheral circulation.
JC: (Z. americanum, Z. clava-herculis, Z. faxineum bark and berries. Berries are considered more effective, as they contain a volatile oil.)
• General stimulant (including cardiac), tonic, alterative, pungent, deobstruent, diuretic, antiseptic, diaphoretic, sialogogue, nervine. Plus, the volatile oil (found in the fruit) is stimulant, antispasmodic, carminative, acts principally upon mucus membranes.
• Dispels obstruction from all parts of the body.
• Asthma, cholera, cold extremities, colds, colic, diarrhea, dropsy, dyspepsia (atonic), female problems (chronic), flatulence, hepatic problems, lumbago, paralysis (including of tongue), pharyngitis, syphilis, rheumatism (chronic), scrofula, skin disease, poor circulation, mouth sores, toothache, ulcers, wounds. Can be chewed for mouth sores and toothache.
• Rheumatism liniment: mix 1 ounce [28.4g] of the herb in 4 ounces olive oil. Use with massage.
NAH: (Z. americanum, Z. clava-herculis)
• Stimulating to the circulation (the berries are reputedly more powerful than the bark, which is also used in Western herbalism) – causes blood to flow to the periphery, promotes sweating (helps reduce fevers).
• One common name is “toothache tree” since it can be chewed as a counter-irritant for toothache pain.
• Warms the stomach, stimulates the salivary glands and mucous membranes, reduces colic and flatulence, strengthens debilitated digestion, especially if the pulse is weak and the tongue is pale and flabby.
• Considerable reputation for allaying rheumatic pain.
• Reputed to have anti-cancer activity – the isolated benzophenanthridene alkaloids are reported to be destructive to cells, however, there are no accounts of adverse side-effects from medicinal doses.
Dose: 1.5-6g

 
Jiao Mu: the seed
• Bitter, acrid, cold; enters the bladder and spleen channels.
• Moves water; calms wheezing.
• Edema with fullness and distention or wheezing and cough due to congested fluids.

Dose: 1.5-6g

Ding Xiang – Clove flower bud – “Spike Fragrance”

Nature: acrid, warm

Enters: Spleen, Stomach, Kidney

Actions: Warms the middle Jiao; descends stomach Qi; warms the kidneys, tonifies kidney Yang.

Indications:
• Stomach cold: hiccups, vomiting, poor appetite, abdominal pain, diarrhea.
• Kidney Yang deficiency: impotence (Fu zi is superior), clear vaginal discharge (usually accompanied by weakness in the legs).
• Spleen or stomach cold from deficiency: lack or appetite, vomiting, diarrhea.
• Topical: fungal infections. (Treatment should not be interrupted.)
• Use as a powder locally or a rinse for toothache. Long history as a dental anaesthetic.
• Male cloves are preferred, as they provide a faster onset of action.
• Increases secretions of sputum from the gastric mucosa without increeasing acidity.
• Contraindicated in combination with Yu jin.
Hsu: Broad antibacterial, antiviral, antifungal; tranquilizing; adrenaline-antagonizing action – inhibits excitory transmission of the AV nodes of the heart; vasodilator; stimulates the uterus.
HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.
BF: The Ben Cao Zai Xin says this herb opens the nine orifices, soothes depressed Qi, eliminates wind, and moves water.
DY: Scatters cold, stops pain.
• Male flowers, Gong ding xiang (“Spike Fragrance Father”), is reputed to be more powerful than the female flowers, Mu ding xiang (“Spike Fragrance Mother”).
• With Shi di to effectively warm the middle burner and scatter cold, downbear Qi counterflow, and stop hiccups. For indications such as:
– 1. Hiccups due to cold in the stomach.
– 2. Nausea and vomiting due to deficiency cold in the spleen and stomach.
– For these indications, this pair is present in Shi Di Tang. For hiccups, add Chen xiang.
Ding xiang you, the aromatic oil extracted from cloves, warms the stomach and scatters cold. Applied externally, it treats epigastric pain, rheumatic pain, and toothache due to cold.
Yoga: Lavanga: K, V-; P+
Rajasic.
• Analgesic, stimulant, expectorant, carminative, mild aphrodisiac.
• Topical: administer the oil in the ear for tinnitus.
JC: Stimulant; the most powerful aromatic/carminative; stomachic; expectorant; anti-emetic; antispasmodic; astringent; rubifacient; antiseptic; digestive; increases circulation, stimulates excretory organs, stimulates and disinfects the kidneys, skin, liver, and bronchial mucous membranes.
• Toothache (use the oil), vomiting (especially in pregnancy), cholera, ague, infant convulsions (use a poultice on the nape of the neck), colic/flatulence (use a poultice on the abdomen), neuralgia, diarrhea, griping, hypotension, palsy, rheumatism, zygotic disease, nausea, epilepsy.

Dose: 1.5-4.5g (0.5-1g directly as powder)

 

Clove Essential Oil (topical)
K&R:
• Key for fatigue, memory loss, depression, colitis, weak libido.
• Oxytocic, aphrodisiac, parasympathomimetic, sympatholytic.
Water: severe fatigue, anergy, depression, melancholia, memory loss, impotence, frigidity, diarrhea from chronic intestinal disease, Crohn’s disease, hemorrhagic rectocolitis, headache, UTI, edema, renal insufficiency, dental cavities, deafness.
Metal: pulmonary infection, tuberculosis, anorexia, parasites, chronic diarrhea, aerocolitis.
• Strong topical antiseptic/antifungal.
EODR:
• Phenomenally powerful antioxidant.
• Anti-aging, anti-tumor, antimicrobial, antifungal, antiviral, analgesic/anesthetic, antioxidant, anticoagulant, anti-inflammatory, stomach protectant (ulcers), lice, toothache, acne.
• Scent: mental stimulant; encourages sleep, stimulates dreams, creates a sense of protection and courage.
• Dilute 1 part EO with 4 parts fixed (seed /vegetable) oil; apply 2-4 drops on location, gums, or mouth.
• For tickling cough, put a drop on the back of the tongue.
• Caution: anti-coagulant properties can be enhanced when combined with Warfarin, aspirin, etc.

Fu Zi – Zhi Fu Zi – Prepared lateral (daughter) root of Aconite – “Appendage” or “Attached Son”

Nature: acrid, hot, toxic

Enters: Heart, Kidney, Spleen, and, according to some sources, all other meridians, too

Actions: Restores collapsed Yang; tonifies heart fire, unblocks the vessels, and improves circulation; tonifies kidney Yang; disperses cold, warms the channels, relieves pain; reaches the 12 channels.

Indications:
• Yang collapse: cold sweats, cold extremities, feeble pulse, diarrhea with undigested food (often after severe vomiting, diarrhea, or sweats). In these cases, Fu zi assists the heart Yang to unblock the vessels and improve circulation, and tonifies kidney Yang to augment fire and avoid loss of the source Yang.
• Heart, spleen, or kidney Yang deficiency: any associated patterns.
• Wind-cold-dampness: Bi syndrome, especially when cold is predominant. Also for cold blocking the organs, channels, sinews, bones, or blood vessels.
• Congestive heart failure.
• Lowers heart rate and slightly lowers blood pressure.
• Anti-inflammatory.
• Guohui Liu uses higher doses on Americans – up to 45g (so far) – and often begins with 10g.
• Guohui Liu recommends cooking Fu zi for at least 2 hours, until it no longer numbs the tongue, while Bensky/Gamble says to cook it for 30-60 minutes before adding other herbs.
• Watch for development of heat symptoms: burning urination, canker sores, bleeding, hard, dry stool.
Gan cao, Gan jiang, and honey substantially diminish Fu zi’s toxicity (as do Xi jiao, Jin yin hua, and Lu dou).
• Symptoms of poisoning: vomiting, diarrhea, palpitations, drooling, nausea, vomiting, lightheadedness, blurry vision, numbness in the mouth and extremities, premature atrial contractions, dyspnea, tremors, incontinence, stupor, reduced temperature and blood pressure, death.
• Atropine and lidocaine have been used successfully in treatment of overdose.
• Contraindicated in pregnancy or Yin deficiency.
• One form of processing renders the herb black, called Hei fu pian or Hei fu zi (“Black Appendage”). Its action is focused on the kidneys.
• Another form of processing renders the herb white, called Bai fu pian or Bai fu zi (“White Appendage”). It is used by some for treating painful obstruction (Bi syndrome).
Sheng fu zi, the untreated herb, is used – rarely – when the full force of the herb is required – usually for emergencies and topical use.
PFGC: Enters and tonifies Ming Men; is pure Yang, moves without being confined, can reach any part of the body.
• For severe cold disorders causing: cold extremities, hiccups, nausea, regurgitation of food, diarrhea, cramps, wind obstruction, masses and accumulations, disorders of the Du Mai with stiffness and rigidity of the spine, chronic infant convulsions, greyish papules, skin ulcerations that do not heal with dispersing herbs.
• Aconite opens the pores to expel wind and cold from inside.
• Some books say that in combination with blood tonics, it can moisten deficiency of original Yin (not for complete water exhaustion).
• In extreme Yin syndromes with signs of false Yang, take the decoction cool.
• Though its action is opening, it also has a strong astringing effect: for profuse sweats from Yang collapse (cold body), diarrhea from intestinal cold, Yang deficiency in the lower Jiao with escaping Yin, cold excess syndromes with spontaneous seminal emission.
• Though all Yang things have the tendency to float upwards, aconite has ability to entice fire downward.
• Boosts both the imperial and ministerial fires.
• When the surface Yang of the Taiyang system floats precariously on the outermost surface, producing fever, aconite has ability to link it with the astringing energy of the Shaoyin system and heat symptoms will naturally disappear.
• If the inner core of the Shaoyin network is diseased, aconite can entice the energy to come up from below and make the pulse reappear.
Wu tou represents the mother Yin which is already depleted of the procreative force.
Tian xiong (an aconite root which does not spread laterally, but just grows fatter) represents the solitary Yang which is unable to procreate by itself.
Fu zi is the seedling of Wu tou and Tian xiong and thus contains both Yin and Yang.
MLT: Main herb for tonifying the Ming Men.
• Antidote to poisoning: mung bean congee (also Atropine).
Hsu: (Fu zi and Wu tou) Cardiotonic – increases contraction of the heart and improves circulation to the whole body; analgesic; antiphlogistic; stimulates the adrenocortical system of the pituitary, benefits patients with dysfunction of the adrenocortical system through adrenocortical hormone-like actions.
DY: Operates within the Qi division; returns Yang and stems counterflow; strongly supplements Yang; in the exterior, it is directed to the skin to drain cold; in the interior, it is directed to the three burners to drain cold; invigorates Ming Men fire; assists Yuan Yang; acts mainly on heart Yang (upper Jiao), spleen Yang (middle Jiao), and kidney Yang (lower Jiao).
• With Gan jiang for mutual reinforcement, to return Yang and stem counterflow. For indications such as:
– 1. Loss of consciousness, cold spontaneous perspiration, cold limbs, and a minute pulse due to Yang desertion. (Si Ni Tang) Use bland Fu zi.
– 2. Pain and a feeling of cold in the stomach and abdomen, vomiting, and diarrhea due to spleen vacuity cold. (Fu Zi Li Zhong Wan) Use blast-fried Fu zi.
• With Da huang (which operates within the blood division) to warm the interior, precipitate accumulation of cold, and evacuate the stools. For constipation, abdominal pain, fear of cold, and cold limbs due to accumulation of internal full cold. (Da Huang Fu Zi Tang).
When the pair of Da huang and Fu zi is combined with Xi xin, it has shown an interesting action in the treatment of cold-damp Bi or impediment with Yang deficiency and blood stasis (use wine mix-fried Da huang for this) as well as for Bi with an accumulation of heat in the stomach and intestines with persistent constipation.
• With Huang qi for mutual reinforcement, to supplement the Qi and warm the Yang, return Yang, secure the exterior, and stop perspiration. For indications such as cold spontaneous perspiration accompanied by aversion to cold, cold limbs, lassitude of the spirit, a pale tongue with white fur, a fine, weak pulse, and in severe cases, profuse sweating, loss of consciousness, and a minute pulse due to Yang deficiency or Yang collapse.
Fu zi is incompatible with soy sauce and millet.
RW: (part of root not specified) Neuralgia (facial/ trigeminal): 5-10 drops tincture (1:5::herb:menstruum) 3 times daily (increase dosage slowly).
IBIS: Actions: sedative, anti-inflammatory, synergist.
• Dosage: Tincture: 0.5 – 8 gtt., up to t.i.d.; Root: 0.06 g.
• Therapy: irritation of mucous membranes, facial neuralgia, fever and inflammation (especially with sudden onset), acute disease with restlessness.
• Toxic amounts of alkaloids have been absorbed through the skin. (Duke, pp. 12-13)
• Internal use may result in immediate oral burning, tingling, numbness, and throat constriction; followed by salivation, gastritis, nausea and vomiting. Characteristic tingling may spread over the entire body surface. Dysarthria, ataxia, vertigo, blurred vision, paresthesias and general weakness can follow. Myotoxic effects include stimulation followed by depression of cardiac, smooth and skeletal muscle. Alkaloidal effects on CNS and peripheral nerves produce a curare-like paralysis with labored respirations spreading from upper extremities to lower. Death from cardiac arrhythmia and respiratory failure occurs within 1-8 hours. (A.M.A., p. 20; Dreisbach, p. 434; Levy and Primack, p. 120; Theines and Haley, p. 24)
• The odor has a narcotic effect and can lead to eye irritation and swelling (Tedeschi, Eckert, and Tedeschi, p. 1525).
• Treatment for overdose: body warming (internally and externally), administration of atropine 0.05 mg/kg body weight, 2 – 3 mg total dose, and a potassium permanganate (1:1000) gastric lavage (Levy and Primack, p. 120; Theines and Haley, p. 24; Cooper, et al; Turnball)
• Laboratory changes: hypocalcemia due to reduction in free Ca++ ions.
Huang Huang lecture notes: [See also his brilliant book, Ten Key Formula Families in Chinese Medicine]

I. Fu Zi
A. We use Zhi Fu Zi (Aconiti Carmichaeli, Radix Lateralis, Preparata)
B. Family Ranunculaceae
C. Standard species: Aconitum carmichaeli Debx. (?? [??] Wü Tóu lit. “crow’s head” or “black head”)
D. Alkaloids: aconitine, hypaconitine, mesaconitine, talatisamine, monoacetyltalatis- amine, isotalatizidine, etc.
E. Decocting takes the most toxic substances and breaks it down those

II. “Fu Zi is the most useful herb and also the hardest to use”
A. Number 1 for restoring the yang & rescuing from rebellion
B. Famous doctors
1. Yan Guan in the Ming used ginger juice treated Fu Zi to the point he was called “Yang Fu Zi”.
2. Zheng Qin-An in the late Qing used Fu Zi and Gan Jiang for all yin type diseases whatever the symptom. Ex. toothache, he would see constitution as weak and would use Fu Zi.  Wasn’t paying attention to disease, but to person.  He was the of the “Fire God” (??  hu? shén) current.  Because he focused on the person, Fu Zi became popular.  This is a very old school.
3. 20th century Sichuanese physician Zhu Wei-Ju became famous when he came to Shanghai.  He used Fu Zi to treat many serious diseases & emergencies. He realized all Shanghai doctors were using Wen Bing formulas.  He had success using Si Ni Tang type formulas so nicknamed him called “Qu Fu Zi.”
4. Famous modern doctor from Yunnan, Wu Pei-Heng called “Wu Fu Zi” because he used very large dosages, up to 400g.  Used large pot to cook Si Ni Tang as one must have a large amount of water, one can’t keep adding water.  If one adds water, this method won’t break down toxic ingredients.
C. Why “Hardest to Use”?
1. Fu Zi patterns can be difficult to differentiate
2. In emergencies once can wait too long and lose the opportunity to use it.  Ex. he saw a patient who had been in extremely cold water, with extremely cold lower extremities.  He used Ma Huang Xi Xin Fu Zi Tang and it worked as he used it immediately.
3. If used when inappropriate, no therapeutic effect
4. As it is toxic, when inappropriately used can have significant side effects.  0.2mg of aconitine can lead to toxic side-effects; 3-5mg can be fatal.  It’s very powerful but very difficult to use:  He worked in an arthritis ward.  There was a very recalcitrant case of upper joint pain, old doctor wanted to use Wu Tou.  After giving her this and she had toxic reaction, and all but died, it took many emergency doctors to revive her…but the pain was gone.

III. Symptoms of Aconite Poisoning
A. Nausea, vomiting, abdominal pain, diarrhea, , blurred vision, mydriasis, burning sensation, numbness of the mouth and tongue, numbness of the limbs or the whole body, restlessness, dizziness, pallor, bilateral loss of vision, difficult respiration, tremors, low blood pressure.
B. Aconitine can directly damage the myocardium; toxicity can lead to ventricular fibrillation
C. Long use side effects:  Fire spirit school’s two main proponents died in their 40’s.  This not a good sign.  Do not take large dosages for a long time to increase longevity.  First use safely, appropriately for heart problems, edema, joint pain.  1. Does this disease respond to Fu Zi? 2. Is  patient right constitution? 3. Must have appropriate matching of other herbs, and correct dosage, and appropriate form of medicine: decoction, pills, granules.

IV. Fu Zi Presentation
A. Most importantFu Zi pulse is faint and thin.
1. Very faint, very thin; almost imperceptible; or
2. Sunken and hidden, so only palpable near the bone; or
3. Suddenly becomes floating, big, soft and empty
B. Usually occurs after profuse sweating, diarrhea, bleeding, etc.; or
C. Extreme fatigue or cold
D. Patient is constitutionally weak or
E. Tongue is moist, cannot be dry.  White coating, big, fat, swollen, dark.
F. Other related symptoms
1. Listless, extreme fatigue, faint voice;
2. Important: People withdrawn, laconic, indolent, no shen, no affect, very fatigued, don’t like to talk, voice low, hard to get history.  [If people come in and talk and talk about being cold, very agitated, and pulse agitated, this not appropriate.]
G. Cold: below elbows and knees, unformed stool, edema, fears cold, frigid extremities;
1. Loose stools or diarrhea, may have undigested food particles and also abdominal fullness and pain
2. Edema — especially pitting edema of the lower limbs swollen face, legs, ascites, pleurisy, decreased liver and kidney function.
3. Blood pressure, cardiac function, renal function all low
4. From one perspective equals yang deficiency or shaoyin disease
H. #2 Most Important Severe Pain
1. While pale and weak, white ashen face, yet also irritable and uneasy with generalized or non-fixed pain [e.g. cancer and CNS related pain]
2. Joint pain to the point of breaking out in a sweat [e.g. gout, discogenic pain];
3. Intense abdominal pain without tenderness or hardness and no redness of the tongue or yellow greasy coating;
4. Chest pain that goes through to the back with icy cold past elbows/knees like angina.
5. Sciatica type pain. Think of Gui Zhi Jia Fu Zi Tang.
6. But not for pyschogenic pain.

V. Fu Zi constitution
A. Dark, slightly puffy complexion
B. Dispirited, listless, lusterless eyes, no spirit in the eyes, shallow breathing, laconic
C. Fatigue, difficult to get out of bed
D. Chills, no thirst
D. Sunken, faint, weak pulse without force

VI. Comparison with Gan Jiang
A. Fu Zi: primarily cardiovascular issues with a sunken frail pulse; good at treating pain, while:
B. Gan Jiang: primarily digestive issues with a white, greasy tongue coating; good at treating distention and fullness of the abdomen

Fu Zi family of formulas
I. The family
A. Sì Nì Tang (Frigid Extremities Decoction)
B. Sì Nì Jia Rén Shen Tang (Frigid Extremities Decoction plus Ginseng)
C. Zhen Wu Tang  (True Warrior Decoction)
D. Fù Zi Li Zhong Wán (Aconite Accessory Root Pill to Regulate the Middle)
E. Fù Zi Xiè Xin Tang (Aconite Accessory Root Decoction to Drain the Epigastrium)
F. Wu Tóu Tang (Aconite Decoction)

Sì Nì Tang (Frigid Extremities Decoction)
N.B.: This is the most important of the Fu Zi family formulas.

I. Classical Functions
A. Restore the yang
B. Rescues from rebellion

II. Original formula dosages
Fu Zi 1 piece (If robust use a big piece)
Gan Cao 2 liang
Gan Jiang 1.5 liang

III. Classic Presentation

A. Pulse so faint as to be almost imperceptible, very low BP
B. Frigidly cold extremities and chills;
C. Incessant diarrhea with undigested food particles, with abdominal pain.

IV. Dosages based on Experience
Zhi Fu Zi 30g
Gan Jiang 15g
Zhi Gan Cao 15g
Water decocted

V. Indications
A. Shock from any cause, usually add Ren Shen [Korean Ren Shen is best]as in Si Ni Jia Ren Shen Tang.  Cardiogenic shock.  Dr. Huang has used Si Ni Tang + Zhen Wu Tang + Rou GuiFu Zi to 50g.
B. Cardiac Insufficiency marked by fatigue, shortness of breath, palpitations, weight loss, muscular atrophy, being bedridden.
C. Unrelenting diarrhea: For acute gastroenteritis, chronic colitis, or infants with rotavirus gastroenteritis — add Huang Lian; sudden turmoil disease.  Most often no significant rise in temperature, cold limbs, listless.
D. Long-standing Stomach Problems: For chronic gastritis, peptic ulcer, and functional indigestion.  One usually adds Huang Lian, Huang Qin, and Da Huang, particularly in robust men with good appetites that get full easily and have a tendency towards pain and diarrhea. N.B.: This is Si Ni Tang plus + Xie Xin Tang
Fu Zi 10
Gan Jiang 10
Gan Cao 5
Huang Lian 2
Huang Qin 5
Zhi Da Huang 5
Sometimes one may add Rou Gui 10 for abdominal pain.  There are usually signs of cold and heat: a robust person but with a dark face, a thick tongue coat, but white, can eat a lot but gets diarrhea.

VI. Constitutional Findings
A. Face: dark, pale, or dark yellow complexion; listless; appears tired; lusterless and baggy eyes; dark, washed-out, and dry lips
B. Tongue: pale, swollen, and dark with many teeth-marks; the coating is white & thick, black & moist, or white & slimy
C. Body: soft & loose flesh without tone; usually dry skin that lacks luster
D. Habitus: fears cold & attracted to warmth, cold limbs [especially lower]; easily fatigued, indolent
E. Loose, unformed stools; profuse, clear urine; no thirst or only drinks a little or fond of warm liquids
F. Weak forceless pulse.
G. Abdomen may be distended but no pain or resistance.  May not even be cold.
N.B.: If a patient presents like this no matter why he comes in, one should give him Si Ni Tang.  This presentation is not rare, due to overuse of antibiotics and intravenous infusions, overindulgence in cold foods and drink and rich food, flimsy fashions, over work, air-conditioned environments, and sedentary lifestyles.  When antibiotics kill good bacteria, this is yang xu.  They overuse them in China for everything.  Pre-modern physicians used Si Ni Tang for some problems, such as sudden turmoil, that are not that common focus at present

VII. Shu vs. Sheng Fu Zi
A. Originally used unprocessed. The classic use of unprepared Fu Zi to restore the yang should be taken seriously  However, Gan Jiang and Gan Cao were added.  These decrease toxicity as well as warm.  These three are mostly used together, they are more functional and less toxic.  If one uses a large does of Fu Zi, must combine with these other herbs.  If one uses prepared, it is not necessary to use Gan Jiang and Gan Cao.
B. If use unprocessed, should boil water first then cook longer.  Zhang boiled Wu Tou with honey.  Perhaps the honey raised the boiling temperature.
C. Wu Pei Heng used decoctions of sufficiently cooked Fu Zi or Si Ni Tang with Rou Gui for toxicity from insufficiently cooked Fu Zi.
D. Fan Zhong Lin, late 20th C, Sichuan doctor skilled in using Si Ni Tang, emphasized the tongue:  Pale red or pale and dark, swollen with teeth-marks, gray and greasy or white and slimy coat. Dr. Huang feels this is not sufficient, need pulse, face, affect, etc.

VIII. Si Ni Tang vs. and Si Ni San
A. A Si Ni San presentation usually has only the hands and feet cold, tight rectus muscles and pain in the chest and hypochondrium.  The eyes are looking out and vigilant.
B. In a Si Ni Tang presentation the hands and feet cold are colder, no response below ribs, dull ribs.  The mental and emotional states are completely different, the eyes are dull.
IX. Si Ni Tang + Rou Gui
A. Si Ni Tang plus Rou Gui is the formula of choice for shock, profuse spontaneous sweating, and abdominal pain.
B. In emergencies when there is not time to prepare Si Ni Tang, first use an infusion of Rou Gui.

Sì Nì Jia Rén Shen Tang
I. Indications
A. Common addition for patients with intense diarrhea, sweating, or hemorrhage.  For acute but also chronic diarrhea.
B. Any hemorrhage.
C. Manchurian Korean ginseng is preferred.

Zhen Wu Tang 
I. Classical Functions
A. Warms the yang
B. Promotes water metabolism

III. Dosages based on Experience
Prepared Fu Zi 10-20g
Fu Ling 15-30g
Bai Shao 15-30g
Sheng Jiang 15-30g
Bai Zhu 15-30g
Water decocted

IV. Classical Presentations
A. “The person still is feverish with palpitations below the heart, the head is dizzy, and the body twitches and trembles like it is going to fall on the ground” (82)
B. Abdominal pain, urinary dysfunction, a feeling of heaviness and pain in the limbs, and diarrhea”(316)
C. “The person might cough, or have [dysfunctional] urination, or diarrhea,

V. Key Symptoms
A. Twitching & Trembling like one is going to fall down. This is like a description using only the lineaments of the person, the main outlines.  Shows a person that has vertigo-like symptoms, unsteady, head is disconnected.  Described in lots of ways, walking on cotton or clouds, feel like going to fall to one side, or as follows.
B. Often seen as being weak and unsteady
C. Patient may describe as feeling as if they are walking on cotton or clouds
D. Others may say that their heads feel heavy and their feet light

VI. Accompanying symptoms
A. Digestive complaints: abdominal pain, unformed stool, or diarrhea with no particular precipitant
B. Scanty urine
C. Systemic edema, but especially in abdomen where there is yang xu with fluid buildup.
D. Heavy and painful limbs.  It’s hard for the patient to move because of the excess fluids

VII. Constitutional Findings
A. Listless, no spirit in eyes, may be extremely fatigued, fear of cold with cold limbs from a major disease;
B. Excess water, superficial edema, or diarrhea, or urinary dysfunction, or palpitations, or tremors.  Water in a discrete place, not just in flesh, in abdomen, in head, etc.
C. Tongue is important: swollen, large, pale with white or gray coating and slimy
D. Pulse: sunken, thin or large, empty, & weak.

VIII. Usage
A. Collapse; heat exhaustion
B. Sudden nausea, dizziness, pallor, shallow breathing, cold sweat, weakness; may collapse
C. From inappropriate use of Ma Huang Tang or due to too much sweating.  If mild symptoms, just use Gui Zhi Gan Cao Tang, if more intense, use this.
Case History: Sweating from inappropriate use of Ma Huang Tang.
A male patient, with slight sweating at the onset of a disease, a weak pulse, and aversion to drafts.  After mistakenly treated with Ma Huang Tang he experienced nonstop sweating, feverishness, chest pain, jumpy with palpitations, unable to sleep at night, incoherent speech, tremors, shakes.  Dr. Xu – treated him with Zhen Wu Tang.  Main issues better after 3 packets.
N.B. Almost all instances of non-stop sweating in Shang Han Lun are due to inappropriate use of Ma Huang Tang, take Ge Gen Tang in the evening, etc.  Everything in this case history point to side effects of Ma Huang Tang.  Xu also added things to clear heat.
Case History:  Sweating from yang collapse, 1970, Hennan.  Mr. Zhang, 34 y.o.; thin and somewhat debilitated. Took exterior-releasing herbs two times for a wind-cold and then a purgative.  This resulted in profuse, continuous sweating, bedclothes soaked, listless, low fever, tight musculature, dizzy to the point of being unable to stand; excretions normal; pulse sunken & thin.  Dr. Huang: This guy was already debilitated, given too strong diaphoretic and purgative.  Too much sweating lead to yang devastation.  Dizziness is marker as well as tremors.
Formula:
Zhi Fu Zi [cooked 1st] 30g
Bai Shao 30g
Bai Zhu 30g
Fu Ling 30g
Sheng Jiang 30g
Decocted and sipped over time.

IX. Other and modern diseases
A. Dilated cardiomyopathy
Young people have an enlarged heart, this is congenital.  Often need heart transplant, but these are hard to come by, so may be willing to take Chinese meds.  They are overweight, edematous, add Huang Qi, Rou Gui, looks like Zhen Wu Tang with Huang Qi Gui Zhi Wu Wu Tang.  These probably won’t cure this but can improve the quality of life.
Case History: Congestive Heart Failure, Zhao Xi-Wu, Academy of Chinese Medicine uses Zhen Wu Tang.  This has Fu Zi but also diuretics.  This combo of strengthen heart with diuretics is very good. It is usually combined with Sheng Mai San, Wu Ling San [increases urination, if can’t urinate, feel heavy and encumbered.], Ma Xing Shi Gan Tang [Ma Huang with a weak heart is not a great idea, but used properly it is OK, especially with cough and wheeze. etc.] After taking herbs there is a significant increase in urinary output, ease of breathing, no pharmaceuticals are required.  Dr. Huang adds Rou Gui, Huang Qi, Long Gu, Mu Li. This patient couldn’t move, with wheezing, spit up pinkish sputum, left ventricular type.  Besides wheezing have enlarged liver, ascites, extreme edema of legs.  Heart problems are the main reason for death.  Most people take Western meds, but Zhao started to treat it.
Case History: Chronic Bronchitis And Asthma. A woman had chronic bronchitis and asthma , was bent over, took steroids causing a hump and edema.  Dr. Huang used Zhen Wu Tang with the above additions.  She took it ½ year, she improved slowly, and could finally walk.
N.B. Zhen Wu Tang may keep these people out of crisis, out of hospitals even if they are not much improved.
Case History: Undiagnosed Heart Problems.
Monk, 30+ years old, with irritability and oppressive sense in the chest for a few days followed by dark blood from both vomiting and diarrhea.  Sunken and faint pulse; extreme abdominal fullness, urinary difficulty, swollen limbs that are heavy and numb, 2-3 bowel movements a day, low spirits and no appetite.  Food stagnating in the chest that causes the qi to be upset when it enters the ?  May also have had ascites. He recovered very fast with Zhen Wu Tang.
N.B. Dr. Huang feels people who don’t take herbs all the time seem to respond to less and lower doses.
Case History: Hypertension
Female, 70 y.o. with hypertension for over 10 years. 1st visit 180/100mmHg, as has not taken her meds for the last couple of weeks.  Palpitations, dizziness, unsteady feet “as if walking on cotton.” Slight leg edema, lack of appetite. Tongue – pale, white slippery coat; Pulse sunken, thin, normal force.
Formula:
Fu Zi 10
Chuan Wu 10
Bai Shao 10
Fu Ling 15
Cang Zhu 10
Sheng Jiang 15
3 days later symptoms lessened, BP160/90 mmHg.  10 more packets- BP140/80mmHg; herbs stopped and at 1 year follow up was OK.
N.B. HBP not necessarily liver yang rising.  If yang xu, use Zhen Wu Tang.  These people are unsteady, dizzy, and have edema.  Get rid of excess fluid their blood pressure comes down.  Ex. a village doctor uses the classic formulas very well.  He wrote a good book, became famous, moved to big city.  Used to farm half time, because he was alone he knew how to make medicinals.  He used this strategy with success.
N.B.: Erectile Dysfunction can be a side effect of long-term Western meds, Chinese meds are better since they do not have so many side effects.  Current doctors look at numbers for results, not at how patients feel.  So if these Western meds cause these sorts of problems it is often overlooked.
B. Chronic Renal Disease
Sallow complexion, lower limb edema, unformed stool, proteinuria.  The general formula is  Zhen Wu Tang plus Yu Ping Feng San plus Wu Ling San.
Case History: Chronic Renal disease
Woman in early sixties, quite severe.  In hospital she would have gone to the renal department, but because she had a fever, they sent her to Dr. Huang.  Fever, no urination, adverse to cold and sweating.
Formula: Zhen Wu Tang plus Yu Ping Feng San + Gui Zhi.  She said it worked and tasted good, that before the Chinese herbs were terrible tasting and with huge packets of herbs, with disgusting herbs.  This was because the combinations were formulated by using the biomedically-defined functions of the herbs.  These were not formulas, just a bunch of herbs thrown together.  In comparison Dr. Huang’s were better tasting and he used many fewer herbs.  She decided to continue to see him.  She started with 3+ proteinuria and these numbers just went down.  Then her family came to see him.  She is still OK.
C. Cirrhosis with ascites
The general formula is Zhen Wu Tang with Wu Ling San ­and ­Huai Niu Xi:
The dosages are:
Fu Zi 30
Bai Shao 30
Chi Shao 30
Bai Zhu 30 up to 60
This increases diuresis, maybe it dilates blood vessels around kidney.
N.B.: Ascites, the first time a patient has it, it is easy to cure, but recurrences get harder and harder to treat.  By the time they are referred to Chinese medicine, cases may be very difficult.  Sometimes Chinese medicine can still help.
Use large doses of Niu Xi, smaller of Fu Zi, maybe 10g.  Bai Zhu takes interperineal fluids and disperses them; increases albumen in blood.  It is kind of a natural albumen, sounds like egg white in Chinese.  North of Shang Hai is the epicenter of cirrhosis, Mao Han Ping, old doctor there uses large doses of Bai Zhu with success.  Bai Shao is also very important.  It regulates immune system, unblocks obstruction of blood, dilates blood vessels.  Wang Chen Bai, Beijing military doctor, originally Western, then Chinese, is a very good liver disease doctor.  He has his own special formula, Chi Shao, Dan Shen are the main ingredients for stubborn jaundice.  Chi Shao dosage quite high, maybe up to 80g.  There is a need to break up the constraint.
Severe liver disease patients often have spasms of lower legs.  A cirrhosis patient of Dr. Huang’s had horrible restless legs, he used Xiao Jian Zhong Tang with large dosage of Bai Shao, not only did the restless leg go away, but ascites improved.  For liver disease, must use large dosages of Shao Yao, for spasms use Bai Shao, for stubborn jaundice, use Chi Shao.  Large dosages of Shao Yao may be a laxative.  A small dose is 15-20g.
Case History: Jaundice
Billiary obstruction, itchy skin, constipation.  Dr. Huang asked if there were leg spasms, patient said yes, so he used Shao Yao Gan Cao TangBai Shao 30, Gan Cao 10 per day.  This is a relatively inexpensive formula but all the patient’s functions improved, and she was astounded.  Western surmised that maybe spasms around the billiary tract was original cause, but this was uncertain.  5 years later she is OK.  If splenomegaly
Bie Jie , Long Gu, Gui Zhi.  A young patient had this with large portal vein, not only symptoms improved but portal vein became normal.  This made a big impression on Dr. Huang.
D. Cirrhosis with portal hypertension:
The general formula is Zhen Wu Tang with ­and Rou Gui, Long Gu, Bie Jia.
There is some evidence this may control the progression of the disease.
Case History: Cirrhosis (see power point for pictures of this patient.)
1st visit 2006-02-07 Chief Complaint: positive Hepatitis B tests -HbsAg,anti-HBe,antiHBc.  History of other positive Hepatitis B tests with a history of others in his family having liver disease. DISEASE  – cirrhosis, organomegaly.  Decreased appetite, averse to cold, stomachache, hypochondrial distention &pain, averse to greasy foods with diarrhea after eating them, abdominal pain post BM.  Portal vein measures 1/3-1.4cm.  HR 90 beats/min, pitting edema lower limbs;  pale, tender tongue with white, greasy coat; middle level of the pulse is empty .
Formula:
Zhi Fu Zi 6g
Bai Shao 30g
Bai Zhu 30g
3rd visit 2006-03-07:After taking the herbs his appetite increased, stool became formed, and throat pain was gone and abdominal distention is not that noticeable. Still slight edema of the legs; pale red enlarged tongue.
Formula:
Zhi Fu Zi 6g
Bai Shao 30g
Bai Zhu 60g
Fu Ling 30g
Zhu Ling 30g
Ze Xie 40g
Rou Gui 6g
Gui Zhi 10g
Gan Jiang 6g
Da Zao 30g
4th visit 2006-04-29:Complexion improved, stool is formed; leg edema; tongue pink with a thin, white coat; pulse moderate, empty, & big.
14th visit 2008-04-22:Appetite and stool are OK, has gained weight; BP140/95mmHg; slight edema of the legs; tongue enlarged and tender with a thin coating; bleeds when brushes teeth, conjunctiva are red and moist, symptoms of anemia are improved.
Told to avoid overly hot or hard food
Formula:
Zhi Fu Zi 10
Tia Xiong 10 [added by patient]
Bai Zhu 60g
Bai Shao 30g
Fu Ling 20
Gan Jiang 6
Rou Gui 10
Da Zao 20
15th visit 2008-06-03: Less sensitivity to cold, pain over liver area is not very noticeable, the spleen has gained 1mm in width over the last month.
Formula: add 15 each of Long Gu and Bie Jia
2011-06-15 Ultrasound: Diffuse changes in the liver with nodularity, thickened wall of the gallbladder, enlarged spleen, portal vein wider
Formula:
Zhi Fu Zi 10
Tia Xiong 10
Bai Zhu 60g
Bai Shao 30g
Fu Ling 20
Gan Jiang 10
Sheng Long Gu 15
Bie Jia 15
This is a two day dose.
This disease was not cured but controlled and progressing slowly.  No ascites, no vomiting of blood, no western meds.
E. Hypothyroidism:
Combine with Dang Gui Shao Yao San, if listless Ma Huang Fu Zi Gan Cao Tang.
F. Perimenopausal syndrome
With cold and painful joints, spontaneous sweating: combine with Gui Zhi Jia Long Gu Mu Li Tang
Case History: Perimenopausal syndrome
Fear of cold, sweats a lot, thyroid normal.  Patient previously used Huang Qi and Shi Gao, lots of astringents, which didn’t help much.  Dr. Huang gave her Rou Gui, a couple weeks later, sweating went down.  Still had cold throat and was cold with edema but felt better.  Used Zhen Wu Tang + Rou Gui and Hong Zao.  She got better.
With lots of cold combine with Gui Zhi Jia Long Gu Mu Li Tang. Pulse should be weak, some sunken, some floating.  Tired very easily, joint pain.  To fit this, the patient shouldn’t have emotional problems.
G. Intestinal tuberculosis, peritoneal tuberculosis:
This usage pioneered by Otsuka Keisetsu
Case History: Headache
Case of Liu Du-Zhou.  Li X, middle-aged male chauffeur . In the
summer he usually drinks large volumes of cold water or beer and developed a headache in the fall that was worse at night. To control the headaches he had to smack his head with his palm or take analgesics; he really suffered. His vision had also been cloudy for over a month. His complexion was very dark, tongue pale with a slimy coating, & pulse sunken, wiry, and moderate. DX – Yang deficiency with overflowing fluids, turbid yin scurrying upwards to veil the clear yang
Formula:
Fu Zi 12,
Fu Ling 18
Bai Zhu 9
Sheng Jiang 12
Zhen Wu Tang is great for pain.  Complexion is very important in the diagnosis: dark, no luster; and make sure the tongue is correct.  Make sure the problem is due to cold, not heat. He added Gui Zhi, and finished with Ling Gui Zhu Gan Tang.
Case History: Cervical Spine Case
Case of Hu Xi-Shu.  Vertigo, palpitations, left posterior shoulder pain, tension and pain in the left hand with aching above and below the elbow. Frequent nocturia, a pale tongue with a greasy white coat on the root, and a sunken, slippery pulse.  Diagnosis: Yang deficiency with pathogenic water attacking upwards
Formula: Unmodified Zhen Wu Tang:
Fu Ling 12
Bai Shao10
Sheng Jiang 10
Bai Zhu 10
Zhi Fu Zi 6
After 3 packets the dizziness was less, but everything was unchanged. Increased Zhi Fu Zi to10 & add Gui Zhi 10 and Zhi Gan Cao 10 for another week – shoulder and back pain was better.
N.B.:  Both these famous jing fang doctors added Gui Zhi for pain.  Both influenced by Japanese book Han Dynasty Medicine. Talked about presentation matching formulas, no zang fu, wu xing.  He is now very popular, wasn’t respected in his time, too practical, not theoretical.  He was very good, very based in SHL presentations.  Used Da Chai Hu Tang and Gui Zhi Fu Ling wan for asthma, Da Chai Hu Tang for GB stones.
H. Arthritis
Cold, painful type.
Case History: Tremors
90 y.o. man who had fallen into a river in December. For the fortnight since he had been sensitive to cold, especially at night, and also had cold tremors during which his whole body would shake uncontrollably as if he had been severely frightened. No fever or pain, he had no other major complaints, and was in relatively good spirits.  Tongue: pale and enlarged; white, greasy coat.
Formula:
Zhi Fu Zi 20
Fu Ling 20
Bai Shao 15
Bai Zhu 15
Sheng Jiang 15
After 5 packets she was cured.
N.B.: There was a student’s case history.  When you see people with shivering, shaking, tremors, see if they fit a Zhen Wu Tang constitution, must be correct constitution to work.
Case History: High Fever & Edema
86 y.o. man in hospital due to stroke had a fever of at least 39C° for a month that had not responded to any antibiotic. Not only comatose but on respirator. Ice pack on head.  Enormous abdomen, very soft, scrotum very enlarged, edema in legs, pulse irregular change from large to small.  Dr. Huang used Hong Shen, Rou Gui, with Zhen Wu Tang.  Put it down his nose.  Patient’s temperature went up, but Dr. Huang said don’t worry, take ice pack off head.  Also stop giving him so much food.  Finally his temperature, it went down 1/5 degree, stayed there for a while, but his face better, pulse better.  Dr. Huang added Huang Qi 60, and reduced Fu Zi.  Then temp start to decrease, edema decreased, returned to consciousness, scrotum got smaller.  He likes to see ICU: these patients are so sick it is apparent what is wrong, get well quickly.
I. Insomnia
Will have some Zhen Wu Tang corroborating factor.  Common in post-menopausal women, women can become yang xu with night sweats or spontaneous sweats, HA, joint pain.  Women’s sleep best in their 20-30s, body is warm, sleep best, menses copious, red lips, red tongue.  If there are mouth ulcerations, dry stool, these are from fire.  But these women are also beautiful and sex drive high, and sleep the best.  Women need this fire, after 50 as fire goes out, face turns yellow, lips dry, breasts sag, legs get thick, with insomnia.[11]
Case History: Insomnia
Woman 55, sallow complexions, unformed stool, very fatigued.  Sleeping 2 hours a night.
Zhi Fu Zi 15
Bai Shao 15
Bai Zhu 15
Fu Ling 15
Gan Jiang 10
Gan Cao 10
Long Gu 15
Mu Li 15
Gui Zhi
Gui Zhi Jia Long Gu Mu Li Tang is aimed at insomnia and sweating.  Things improved, better sleep.
Case History: Insomnia
35 year-old man.  Slept only 2 hours a night.  Tongue red, urine yellow, dizziness, lack of clarity, trembling in flesh.  Used Zhen Wu Tang, after two bags, sleeping up to 7-8 hours per night.
Case History: endometrium cancer,
Zhen Wu Tang’s usage is very broad.  Dr. Huang used it for endometrium cancer. In this case the patient had very dry stool, blood would come out with mucus.  Many would use have used Da Huang, but hers was a yang xu constitution.  Face was yellow, little fat, dark macula on face, pale lips, also had fatty liver.  Was fairly attractive.  Taking Western meds made her unattractive.  Dark complexion, no period, encumbered feeling, used drugs to stop period, these were stopping yang?  He didn’t worry about stool, just used Zhen Wu Tang with Ma Huang Gui Zhi.  Take a bag one day, then a break for one day.  This is to regulate constitution, or one bag for two days, but one cup a day.  For long term can’t use 3 cups everyday.  Mucus stopped, face better, affect better soon, then one pack every three days.  Ma Huang can unblock stools, stools became softer.
N.B.: To expel cold and damp, adding Ma Huang and Gui Zhi greatly helps, can bring on period.  Amenorrhea may be due to cold, can’t just use blood-moving herbs, need Fu Zi, Ma Huang.

X. Explanation
A. Traditional formula to warm the yang and facilitate water metabolism “yang deficiency with [pathogenic] water.”
B. Yang deficiency = sunken, thin, weak pulse; listless, cold limbs with sensitivity to cold. This occurs in major illnesses.
C. [Pathogenic] water = extra fluids, e.g. edema, diarrhea, urinary dysfunction, palpitations, etc. with an enlarged tongue that has a slimy coat. Sometimes we can see the water, sometimes cannot see it.  Dizziness, unsteadiness, twitching, flustered heart, are also from invisible water in interior.  Can usually see this on the tongue, enlarged and slippery coat.
XI Compared to Wu Ling San
A. Zhen Wu Tang condition is more severe (heart, liver, brain reduced)
B. Yang deficiency is at another level and has effected cardiac and renal functions
C. Psychoemotional state is listless or even stuporus, while in Wu Ling San it is basically normal;
D. Edema is less superficial than for Wu Ling San.
N.B. Wu Ling San types are not listless and withdrawn, just water, no yang xu, but both can have palpitations.  Wu ling San has water in abdomen, gurgling, vomiting of fluids, lots of diarrhea.  In Zhen Wu Tang water is not in the intestines, no gurgling.  Can use these together for lots of water, severe thirst, and vomiting.  For fatty liver, Wu Ling San as a powder helps, since this is damp and cold in liver.

XII. Additions:
A. Ren Shen (Ji Li) add for shock, desertion disease, cardiac insufficiency
B. Rou Gui for palpitations, irregular heart, and for sweat, abdominal pain (below umbilicus, has to do with intestinal spasms.)  Tongue is purplish or dark.
C. Long Gu and Mu Li for palpitations, copious sweating and insomnia.  Pulse will be more floating but without force.  Chi pulse superficial.  Palpitations in lower abdomen, use Long Gu, in heart and chest use Mu Li.  Most often use them together.
D. Ma Huang and Gan Cao not too common because lots of these types of patients have heart problems.  If you want to add them, they should have a healthy heart.  Period not present or scanty, skin is dry and sallow, patients are heavier and robust.

Fu Zi Li Zhong Tang
I. Dosages
A. Equal amounts of:
Zhi Fu Zi large
Ren Shen,
Pao Jiang,
Zhi Gan Cao
Bai Zhu
Coarsely grind into a powder and take 4qian in 1.5 cups of water and cook until .7 of a cup is left; remove the dregs and take.

II. Presentation in Source
A. For deficiency cold of the Spleen and Stomach with abdominal pain, decreased food intake, diarrhea, vomiting, clenched jaw with inversion of the limbs which can lead to cold inversion with deep-set cold, sudden turmoil with toxic viscera, yin macules with miasmic toxin, swollen and ulcerated throat, sores of the mouth and tongue; and a sunken, slow or sunken, thin pulse; also treats overabundant yin that barricades the yang.
B. Formula is what disease does it treat, what kind of constitution is going to have this disease.  Lecture focuses on patient and disease.  This may be an acute disease, fainting, vomiting, diarrhea, severe throat pain.  Then there are chronic diseases: deep set cold problems.
C. Constitution is reflected in the sunken pulse.  Pulse is emphasized because of constitution.  Can have irritability.  Xu cold affecting stomach spleen and overabundant yin barricades yang.

III. Typical Dosages
Zhi Fu Zi 10
Dang Shen 10g
[or Hong Shen 5 g]
Gan Jiang 10g
Bai Zhu 10g
Zhi Gan Cao 5g
These are Dr. Huang’s conservative dosages.  Can use pills, Henan brand.

IV. Indication #1 — Diarrhea
A. Frequent diarrhea with undigested food particles
B. Worse with cold
C. Acute: enteritis, rotavirus gastroenteritis
D. Chronic: post antibiotic diarrhea, post chemotherapy diarrhea
E. Infantile diarrhea with indigestion of milk and stool (frothy) that can be green, white, or light yellow; often seen in summer or fall.  [If unable to administer to a breast-feeding child, give to the mother.]
F. Dr. Huang frequently takes this while traveling to prevent diarrhea that can occur due to fatigue on trips.
Case History: Diarrhea
By Wang Meng-Ying [1808-67?].  Summertime, lots of people getting wen bing.  Doctors were using clear-heat resolve-toxin formulas.  But an older women had diarrhea and vomiting, and Wang decided was not the same as the epidemic, hers was actually cold damp problem.  Why?  Tongue was very dark.  Sometimes this indicates Da Cheng Qi Tang.  Why not here?  Pulse was sunken, very weak and she feared cold and her mouth was not dry, and she was heavy.  So he used Fu Zi Li Zhong Wan with success.
N.B.:  One can often use this for overweight patients with sunken weak pulse.  Look for tongue dark or black, but mouth not dry and there is no thirst.

V. Indication #2 — Abdominal Cold & Pain
A. Seen is chronic gastritis, IBS, acute enteritis, stomach flu, indigestion
B. Also used to treat abdominal pain in horses and donkeys.  Can treat animals, will lie down and get up, listless, legs and ears will be cold, mouth will be white, lots of saliva, then use this.  This is more in late fall and winter, or a cold spring when eating spoiled or damaged forage.
Case Study: ?????????1987?03? ??????????????????6?,?????
Chinese Veterinarian Journal: 1987, 3rd quarter.  Yue Rufu reports he used Fu Zi Li Zhong Tang to treat cold pain in six instances with satisfactory results.

VI. Indication #3 — Digestive Tract Cancer
A. Pancreatic cancer, liver cancer, colon cancer, etc. with bloating, lack of appetite, etc.
B. Especially useful after chemotherapy when the vast majority of patients have no appetite, nausea, vomiting, distention, and diarrhea.
C. If there is intense cancer pain, need at least 30g of Fu Zi
D. Often adds Hong Shen to help gain weight, helps spirit and appetite.

VII. Indication #4 — Bleeding
A. Besides bleeding from the upper digestive tract, also used for dysfunctional uterine bleeding, subcutaneous bleeding, epistaxis.
B. Blood will be thin & dark; the person will be averse to cold and sweat. .
C. Fan Wen-Hu from Ningbo uses to treat vomiting of blood
Case History: Shock
Dr. Huang used this plus Rou Gui to treat his wife who suddenly went into shock from upper digestive tract bleeding while visiting Germany. She ate something wrong, no BM, then black BM.  Said was OK, Dr. Huang went to class.  Wife had cold sweat, fatigue, couldn’t feel pulse.  Luckily was in a clinic, wanted to call ambulance.  Dr. Huang said no.  They had Fu Zi Li Zhong Wan  in granules, he wanted Rou Gui in addition, also sugar.  She has xu cold constitution, dusky lips, no spirit.  Put hot water on belly in place of moxa.  30 minutes later she started coming back.  2 hours later she much better.  Then went to Munich, rested two days, was OK.  Also used congee at lunch.
Case History: Coughing of Blood
Case history of Ning bo.  Coughing of blood, pulse deep, tongue pale.  Ning said must take warm herbs or die.  He used this with Dang Shen 24g and added Pao Jiang 6, Fu Ling 10 g, and 2 bowls of child’s urine (staunches bleeding).  He eventually added San Qi and E Jiao.  He eventually returned  to his original formula plus Dang Gui.   Dr. Huang felt the same about wife, if he had used cold herbs she would have died, with the hot herbs she got better.

VIII.  Indication #5 Shock
A. Cardiogenic shock after an MI with profuse cold sweat. Need a very large dose.
B. Dr. Huang fears this, esp. from fatigue, when he can’t eat regularly, so he always carries the patent and eats it.
C. Also from cold pain from diarrhea with cold sweat, can alleviate pain, let BP rise.

IX. Indication #6 Oral cavity disease
A. Drooling in children, halitosis, oral ulcers, swollen& painful lips, periodontal disease.
B. Usually accompanied by cold, diarrhea, copious, clear urine, neither thirst nor a dry mouth, listless. Lips are gums are usually purplish.
C. Mouth related to stomach. Their state of health usually not good, long clear urine, diarrhea, tired, etc.  Fu Zi Li Zhong Wan may bring pus out of gums and help them heal.
Mouth ulcers, can’t always use heat-clearing herbs, but may add them.  May add Huang Lian to Fu Zi Li Zhong Wan for this.  For drooling, Fu Zi Li Zhong Wan can deal with fluids.

X. Indication #7 Excessive bile after surgery on the Gall Bladder
A. After GB surgery have lots of thin bile leaking out, clear and watery.  This is for cold excretions.

XI. Constitutional Findings
A. Sallow, dark complexion, listless, pigmented skin on the limbs;
B. Decreased appetite, abdominal distention, diarrhea, abdominal pain;
C. Pulse lacks force;
D. White, greasy tongue coating
E. Cold wintry constitution.

XII. Compared with Si Ni Tang
A. Fu Zi Li Zong tang warms and tonifies; the patients are usually thin, have a poor appetite; problems are usually chronic and affect the digestive tract.
B. Si Ni Tang is commonly used to treat acute and serious diseases by restoring the yang and rescuing from rebellion.
C. Fu Zi Li Zhong Wan can be used this way in big dosage.

XIII. Compared with Li Zhong Tang
A. In addition to fear of cold and the digestive symptoms such as diarrhea that mark the Li Zhong Tang presentation, this formula also warms the yang to treat withdrawal, a weak pulse, and other systemic signs and symptoms.
B. “From first to second floor.”  Li Zhong Tang only digestion problem, adding Fu Zi also treats listlessness, a weak pulse, and heart and kidney problems.

XIV: Compared to Zhen Wu Tang
A. With Fu Zi Li Zhong Tang there is free flowing of urine and no edema.

XV. Modifications & additions:
A. For a dark, pale tongue, palpitations, and sweating add Rou Gui, Fu Ling
B. If thin without an appetite and a dry mouth, add Hong Shen
C. For intense pain, increase the dosage of Fu Zi to at least 30g and add Xi Xin.
D. For complexes of cold and heat, can be combined with herbs such as Huang Lian.
E. Can be used for constipation, but only if the stools are first hard then loose and watery.

Fu Zi Xie Xin Tang
I. Introduction and Functions
A. An ancient emergency formula, used for such urgent conditions as vomiting of blood, collapse, and food poisoning.
B. Unblocks the yang and drains focal distention
C. Treats focal distention, chills, listlessness, sweating
D. Used very commonly for the weak, yang xu with bleeding.
E. Do hot and cold herbs cancel each other?  They do their own thing.  Their cooperation helps resolve situation.  Dr. Huang cooks all the medicinals together without the steeping of cold and boiling of hot.  Try this for robust people that don’t respond well to either hot or cold

II. Original dosages and preparation
Da Huang 2 liang
Huang Lian 1 liang
Huang Qin 1 liang
Zhi Fu Zi 1 piece [decocted separately]
Take the above 4 ingredients, chop [the first] three and steep in 2 sheng of water that is just beginning to boil. Wring out [the juice].  Remove the dregs and add Fu Zi juice.  Divide and take warm twice a day.   [Fu Zi is cooked separately, just use infusion of other ones, they are just steeped in boiling water.]
Explanation: The original formula uses boiling water to steep the “three yellows,” Fu Zi is boiled separately.  This method is from Zhang Zhong Jing’s experience, but his rational is not clear.  Perhaps at that time he considered that the three yellows’ [essence] was easily brought out by boiling, however Fu Zi needs to be cooked a long time and therefore must be cooked separately.

III. Classic Presentations
A. With focal distention below the heart, if there is also chills and sweating, Fu Zi Xie Xin Tang masters it. (Shang Han Lun, line 155)

IV. Constitutional Perspective
A. Can be seen as a combination of a Fu Zi presentation with a Xie Xin Tang presentation.
B. While the original text only mentions chills and some sweating, the patient should also be listless or constantly drowsy.
C. Yakazu Domei used this formula for people with a Da Huang Huang Lian Xie Xin Tang presentation who had slightly cold hands and feet and were…

V. Typical Dosages
Zhi Fu Zi 15g
Da Huang 10g [Wine Fried]
Huang Lian 5g
Huang Qin 5g

VI. Constitutional Aspects
A. Discomfort in the upper abdomen, listless or drowsy, irritable and restless, palpitations, easily flustered, laconic or unclear of speech, chills, cold hands and feet, easily sweat;
B. Dry, greasy tongue coating; sunken pulse; and white as well
C. Sallow dark complexion
D. Usually have a history of gastric disorders or hypertension;
E. Most common in the middle-aged to elderly
F. Mental problems indicate may have brain problem to point of infarction
G. History of heart disease
H. Xie Xin Tang is for vomiting of blood, nose bleeds, focal distention.  Fu Zi is for listlessness, weak pulse, fear of cold, etc. tired to the point of hard to eat.  So this is a mixture of hot and cold, xu and shi.

VII. Indication #1 Hemorrhage
A. Hemorrhage from the upper digestive tract, vomiting of blood, epistaxis, cerebral vascular accident.
B. “This is appropriate for stomach disorders or vomiting of blood/nosebleeds whenever the pattern is excessive and hot with a yang deficient constitution.” Zheng Qin-An

VIII. Indication #2 – Stroke
A. Much on this in the Japanese literature.
B. The modern author Long Ye Yi Xiong [????] uses this for strokes where the exterior is cold and the interior hot. This is marked by irritability & incoherent speech.  C. May also have intermittent shaking of the head or spontaneous movements of the hands. For a Xie Xin Tang presentation but with a complexion that is not flushed, average color blood or anemia, cold hands and feet, perhaps a sunken pulse, and usually tension in the epigastrium.
D. Odai Yodo [mid 19th century]
“In the elderly with food stoppage, when they have a feeling of oppression and faint, they are unconscious, have epigastric fullness, icy cold extremities, a blood-drained complexion, cold sweat on the forehead, a hidden pulse that is almost impalpable, it looks as if they have had a stroke. This is called ‘food constraint’ or ‘food inversion’ and Fu Zi Xie Xin Tang is appropriate.”
N.B. Expansion of the ???  This is a pre-operative therapy approach.  Odai’s account may be MI, also GB problems affecting heart. Typically in elderly.

IX. Indication #3–Stomach Diseases
A. Stomach diseases in patients with yang deficient constitutions. Usually the person is robust, swarthy, and has a big belly and an enlarged tongue.
B. Good appetite but easily gets abdominal distention and diarrhea.
C. Usually add Gan Jiang and Gan Cao
NB: Dr. Huang uses this formula mostly for stomach diseases

X. Indication #4 Polycystic Ovary Syndrome
A. Usually with amenorrhea, diarrhea, poor sleep, flushed face with acne

XI. Indication #5 Recurrent oral ulcers
A. This is a sign one can use this formula, if cold constitution

XII. Food allergies
A. Can add Wu Ling San or Ping Wei San
B. If with severe diarrhea, Li Zhong Wan

Dose: 1.5-15g (to 45g or more)

HF:

Heiner Fruehauf, director of the Classical Chinese Medicine program at the National University of Natural Medicine in Portland, Oregon, is the foremost expert (in the West, at least) on the medicinal use of aconite products, a product of his study and elucidation of the Fire Spirit School (Huoshen Pai) of Sichuan herbalism.

Fruehauf notes that aconite had a much more prominent place in Chinese herbalism historically than it occupies today, with contemporary practitioners, especially in the West rarely using it, or limiting use to just a few grams a day. Meanwhile, Fire Spirit School practitioners may use up to 200g a day, and even claimed that sometimes these high doses are less likely to produce “overheating”-type side effects than lower doses.

It is beyond the scope of this website to cover all that Fruehauf has said about the use of aconite (I suggest you search for Fruehauf+fu zi), but I have included a few excerpts from his interview by Bob Quinn, which can be found in its entirety HERE:

“Traditionally, once the aconite tuber was harvested it underwent a number of detoxification procedures involving steaming, soaking in brine, and repeated rinsing in flowing, clean water. Most of these steps are skipped in modern times. Most modern fuzi is over-brined and is not washed properly in flowing water. In the worst case scenario, and this sadly happens all too frequently, the fuzi is processed with bleach or other harsh chemicals. You can imagine that this has a very severe effect on the aconite’s healing properties. Also, modern fuzi slices tend to be small, because the plant was not grown in the right area and in the right manner.

“In the case of fuzi, the area in Jiangyou where this herb is still cultivated by local peasants has shrunk to less than 20 acres in modern times. Most aconite on the market is grown elsewhere in China and is then shipped to Jiangyou, to get a local stamp so it can appear that it was grown where it should have been grown. This is a real tragedy, since there is a real difference; just the visual appearance of the Jiangyou fuzi tuber is much larger than that of fuzi grown elsewhere. Most of the genuine fuzi is snatched up by Korean and Japanese companies who still value ancient herbal traditions. They are very much aware of the superior quality of Jiangyou fuzi, while in the west virtually nothing is known about the dramatic differences in aconite quality due to place, time, and processing. As a clinician you quickly recognize the value of genuine aconite that has been grown and processed in the traditional manner.

“With the modern fuzi most practitioners are forced to work with two things can happen: In the first scenario, the aconite is inert, as if sawdust had been added to the formula. In the second scenario, the patient may develop an allergic reaction to the aconite—and remember, this toxicity stems from improper processing, not any sort of natural toxicity of the plant—and gets some sort of uncomfortable feeling in their body. I can say with great confidence that this sort of reaction is not due to any sort of unwanted toxicity in the aconite itself.

“Genuine fuzi does unfold a powerful function in the body that is unlike other warming herbs like ginger, cinnamon, or evodia. For instance, when you want to treat severe heart failure with edema, or, say, kidney failure in patients about to go to dialysis, it is very difficult to make any progress without this herb in Chinese medicine. There is real power in this herb. The ancient Chinese were not exaggerating when they called it the “King of the 100 Herbs.” For me, as a serious herbalist who specializes in treating patients with debilitating diseases, this was a great discovery and clinical breakthrough. I am very grateful for it. I found it important enough to station a Classical Pearls employee semi-permanently in Jiangyou, to ensure proper processing of the genuinely grown and harvested fuzi. In this way, I can import the real thing for my own clinic and Classical Pearls.

“Insomnia and anxiety are typically defined as being yin-deficient conditions in TCM. Due to the depleting effect of our modern lifestyle however, there is usually an underlying yang deficiency present in these patients. Stress can be defined as a situation when we spend our (yang) life-force rather than safeguarding and storing it. The primary problem we have here is therefore one of yang storage. This is what fuzi does—it entices the yang to go back into a state of storage. When you add Suanzaoren Tang to an aconite based formula, you will thus see much better results in anxiety and insomnia patients than with Suanzaoren Tang itself. This is the approach I have taken in the design of the Peace Pearls.

“Then, considerations of dosage are important in aconite use. According to the Fire Spirit School and even Ye Tianshi, the pioneer of the fever school, heavy doses off an herb cause the qi to go to the lower burner, while light doses cause it to go to the upper burner. This is true not just for aconite, but for any herb. When asking similar questions to physicians in the Fire School lineage, they said that uprising symptoms like palpitations and dizziness—which, again, is most often caused by improper herb processing—can come from prescribing too small a dose of fuzi. Since fuzi is traditionally charged with drawing the fire of mingmen into the battery of the lower burner, higher doses are more appropriate for this purpose. In the case of the Fire Spirit School physicians, they start with 60 grams and go up to 120-200 grams of aconite per day.

“I personally don’t think that extremely high fuzi doses in the amounts I just mentioned are absolutely necessary. In my own clinical practice, I generally prescribe 18-30 grams of these fuzi [concentrated] granules in formulas designed to last a week. Of course, the amount used should match the purpose of the formula. Bamboo Pearls, my main formula for arthritis, rheumatoid arthritis, aching fracture sites and other types of body pain is based on Guizhi Shaoyao Zhimu Tang. This formula deliberately features just 9 grams of fuzi, because the aconite is used here for its function of being the “opener of the twelve channels.” In medium amounts, fuzi drives out body pain. However, if you want to treat severe anxiety, severe insomnia, severe damage to the Heart-Kidney shaoyin layer, severe damage to the taiyin layer that aconite also enters, you need to use higher doses. Note that some classics originally refer to fuzi as a sweet herb; we see this digestive-strengthening focus and taiyin affinity in Fuzi Lizhong Tang for instance. It is also interesting here to note that the Heart was originally labeled as an earth organ before the fire organ designation was added. Even in English we have that convention, by saying that someone is a “sweetheart.” Fuzi is thus primarily an herb to warm, tonify and bolster the yang qi of both postnatal taiyin and prenatal shaoyin network functions.

An important thing I learned from Drs. Lu Chonghan and Liu Lihong is the image of dribbling the ball in soccer. In the game of soccer, you eventually want to shoot a goal, meaning that the sole point of dribbling is to get the ball into scoring position. In this analogy, scoring a goal is to reinforce the vital fire of mingmen with aconite. Dribbling is to remove qi and blood stagnation, resolve phlegm, etc., with other herbs. From the perspective of the Fire Spirit School, all chronic patients will eventually need an aconite formula, even if we see a lot of heat in a patient at first. Eventually, all treatments get to the stage where we need to get between the goal posts by penetrating the Gate of Life (mingmen), also referred to as Kidney yang, and fuzi is the main herb for doing this.

“I find the following formulas most useful for this purpose: First, the aconite base formula in the Fire Spirit School is the historically all-important yet nowadays rarely used remedy Sini TangSini Tang, as I use it, consists of aconite in one of its medicinal forms, whether it is fuziwutou, or even caowu (if there is pronounced body pain); plus a form of ginger, either ganjiang (dry ginger), shengjiang (fresh ginger), paojiang (roasted ginger), or even gaoliangjiang (galanga); and finally some form of licorice, either gancao (unprocessed licorice) or zhi gancao (honey-baked licorice), most commonly the zhigancao. We know this formula as the Shanghan lun approach to life-threatening situations where the spirit needs to be anchored in the body, but in the Fire Spirit School it is the base formula for all chronic conditions once meridian stagnation has been resolved.

“The other aconite formulas I want to mention here are all derivatives of Sini Tang. There is Fuzi Lizhong Tang, a classical modification of the Shanghan lun formula Lizhong Tang, which allows us to affect both prenatal and postnatal realms in the body. It is very suitable to be used as one of those “shoot the goal” formulas—possibly with the addition of some yin tonics and a tiny amount of huanglian, as I have done for yin-yang balance in the Vitality Pearls. Another formula that I frequently use in this context, which originates directly from the Fire Spirit tradition, is Qianyang Dan. This formula, which literally translates as “Submerge the Yang Pellet,” was created during the 19th century by Zheng Qin’an, the Qing dynasty master of the Fire Spirit School. Qianyang Dan is basically Fuzi Lizhong Tang minus baizhu plus amomum/cardamon in the form of sharen or baidoukou. Dr. Zheng and his disciples in the Lu and Peng family lineages look upon sharen and baidoukou in the same way as aconite—an herb that warms, dispels dampness, and most importantly, causes the qi to go back down into storage. Different from the regular definition of these herbs as aromatic appetite enhancers, they are here recognized as key minister herbs for aconite, helping it with the all-important job of getting the yang-qi back into the box. Peace Pearls, one of the aconite formulas recently created for the Classical Pearls line, is essentially a combination of Qianyang Dan with Suanzaoren Tang. The Peace Pearls primarily treat anxiety and insomnia. Qianyang Dan is also at the core of Guanyin Pearls, a remedy addressing hot flashes and other menopausal complaints. Similar to Peace Pearls, Guanyin Pearls combines the yang bolstering effect of Qianyang Dan with the yin tonic elements of Erzhi Wan and Erxian Tang. If just the regular approach of using yin tonics was used to treat these disorders, the primary problem of yang leakage would remain unaddressed. I find that until there is a clear therapeutic focus on this leakage of source yang, it is difficult to make lasting progress in the treatment of anxiety, insomnia, hot flashes, and other conditions involving the upflaring of qi.”

See complete interview and Fruehauf’s many other resources. 

Wu Tou: Aconite main root
• Includes two types: Chuan wu, Sichuan aconite, the garden variety (the form that is commonly used), and Cao wu, the wild variety (even stronger and more toxic, rarely used internally).
• Acrid, bitter, warm, very toxic; enters the heart, liver, spleen, kidney.
• Expels wind-damp, disperses cold, alleviates pain.
• Cold-dampness: Bi syndrome, cold and pain in the chest and abdomen, intense headaches, pain from trauma.
• Severe migratory arthralgia.
• Heart pain that radiates toward the back.
• Better at dispelling cold, eliminating obstruction, and alleviating pain than Fu zi, but less tonifying and more toxic.
• Must be cooked at least 30-60 minutes before adding the rest of the herbs (some say 60-90 minutes).
• Frequently used topically for pain.
• Traditionally not to be combined with Bai mu, Gua lou, Bai ji, Ban xia, Bai wei.

Dose: 1.5-9g

Gan Jiang – Dry Ginger rhizome – Zingiber

Nature: acrid, hot

Enters: Spleen, Stomach, Heart, Lung

Actions: Warms the middle Jiao; rescues collapsed Yang; expels interior cold; warms the Lungs, resolves harmful body fluid, transforms phlegm; warms the channels, stops bleeding.

• Yang collapse: very weak pulse, cold limbs, etc. Gan jiang alone cannot be counted on. Combine it with Fu zi.
• Yang deficiency cold: hemorrhage of various types, especially uterine bleeding – only when the bleeding is chronic, pale in color, with cold limbs, white face, and a soggy, thin pulse.
• Spleen and stomach cold (either Yang deficiency or externally-contracted excess cold): cold and pain in the epigastrium and abdomen, vomiting, diarrhea.
• Lung cold: cough with thin white sputum, difficulty breathing, cold in the back.
• Raises blood pressure (by acting on central sympathetic centers).
• Downregulates some detoxification genes ““ may prevent some drugs from working
DY: Gan jiang is often used to reinforce the action of Fu zi. As a pair, they are used to return Yang and stem counterflow. For specific indications and notes on this combination, see Fu zi in this category.
Gan jiang warms the spleen and stimulates its functions of transformation and transportation. This has the effect of promoting the upbearing of the clear toward the Lungs and the downbearing of the turbid toward the large intestine. Furthermore, it prevents development of phlegm which the spleen tends to discharge into the Lungs. It transforms cold phlegm (the Chinese word for transform literally means “to melt”) in the Lungs by warming the Lungs. This then promotes diffusion and downbearing [by the Lungs]. In turn, this has the effect of regulating and freeing the flow of the water passageways in order to prevent the development of new phlegm, and downbearing the rebellious Lung Qi.
Gan jiang has clearly demonstrated its efficacy for cold-type asthma in clinical practice. It is, therefore, often systematically added to reinforce the impact of conventional treatments for this pattern of cough and asthma.
• With Wu wei zi: While Gan jiang treats the disease mechanism (see previous bullets), Wu wei zi treats the branch manifestations (i.e. cough and asthma) by securing the Lung Qi by its astringent nature. As a pair, Gan jiang andWu wei zi effectively warm the Lungs, transform phlegm, stop cough, and calm asthma. For indications such as cough and/or asthma with profuse, clear, and white phlegm due to cold in the Lungs, Lung Yang deficiency, or phlegm-cold. For these indications, the combination is used in Xiao Qing Long Tang accompanied by Xi xin.
• With Huang lian to eliminate cold accumulation and depressive heat, drain mixed cold and heat, in order to stop vomiting and diarrhea. The pair allows one to regulate upbearing and downbearing, to harmonize Yin and Yang, and to treat mixed cold and heat. The ratio of the two herbs can be adjusted (3-10g each) depending on whether heat or cold is predominant (use equal doses if heat and cold exist in equal proportion). For indications such as:
– 1. Vomiting, acid regurgitation, belching, epigastric pain or distention, and clamoring stomach (a feeling of hunger, burning, emptiness, unease, and sometimes pain in the stomach with nausea and acid regurgitation) due to a mixture of cold and heat in the stomach. (Ban Xia Xie Xin Tang) Use stir-fried Huang lian unless heat is severe.
– 2. Diarrhea, dysentery, and stomach rumbling due to mixed heat and cold and/or disharmony between the stomach and intestines. (Use stir-fried Huang lian unless heat is severe.)
– 3. Glossitis, stomatitis, and chronic, recalcitrant mouth ulcers due to spleen Yang deficiency and stomach fire.
Yoga: Sunthi, Nagara (dry), Ardraka (fresh): V, K-; P+
• Pungent, sweet/heating/sweet. The most Sattvic spice.
• With honey, it relieves Kapha.
• With rock candy, it relieves Pitta.
• With rock salt, it relieves Vata.
• Dry ginger is better than fresh as a stimulant and expectorant for reducing Kapha and increasing Agni.
• Fresh ginger is a better diaphoretic, better for colds, cough, vomiting and deranged Vata.
• The herb is also a heart tonic.
• Use as a paste for pain and headache.
BII: Carminative, intestinal spasmolytic.
• For all symptoms of motion sickness, and also for morning sickness in pregnancy.
• Some anti-inflammatory effects.
• Useful for migraines, arthritic conditions.
• Also useful in: atherosclerosis, headaches, inner ear dysfunction, nausea, vomiting, osteoarthritis, pain (rheumatic), rheumatoid arthritis.
Hsu: Raises blood pressure – reflexively stimulates the vasomotor center and stimulates the sympathetic nervous system.
• Anti-emetic, anti-diarrheal.
DY: This herb is specifically the older, more mature (dried) rhizome.

Dose: 3-12g
Pao Jiang: Quick-fried Ginger (or fried until slightly blackened)
• Bitter, astringent, warm. Enters the liver and spleen. Warms the channels, stops bleeding, alleviates pain.
• Stops bleeding associated with cold from deficiency: bleeding with defecation or uterine bleeding due to Spleen Qi/Yang deficiency such that blood is not held in the vessels.
• Less potent than Gan jiang at warming the interior, though may be better at treating lower abdominal disorders.

Gao Liang Jiang – Galanga rhizome – Alpinia officinarum

Nature: acrid, hot

Enters: Spleen, Stomach

Actions: Warms the middle Jiao, relieves pain.

Indications:
• Cold in the spleen and stomach: pain in the epigastrium and abdomen, vomiting, diarrhea, hiccups.
DY: With Xiang fu to warm the stomach and drain cold, move the Qi, and stop pain. For indications such as pain in the epigastrium alleviated by warmth and pressure, chest and lateral costal distention, and nausea due to cold in the stomach and Qi stagnation. For these indications, the combination is used in Liang Fu Wan. Vinegar mix-fried Xiang fu should be used. In cases of severe cold, a larger dose of Gao liang jiang should be used. In cases of severe Qi stagnation (as evidenced by epigastric distention and pain aggravated by pressure), a greater quantity of Xiang fu should be prescribed.
Gao liang jiang is very acrid and drying. Its action is drastic, and it should not be prescribed over a long period of time, for fear of damaging stomach Qi and Yin.
PCBDP: Carminative, stimulant.
• Dyspepsia.
• In a paste with bloodroot [Sanguinaria] to treat periodontal diseases (including gingivitis) and skin cancer.
• Has anti-ulcer activity, possible anti-tumor activity.
Hsu: Stomachic, analgesic (stronger than Gan jiang), broad antibacterial.

Dose: 1.5-9g

Hu Jiao – Black Pepper – “Barbarian Pepper”

Nature: acrid, hot

Enters: Large Intestine, Stomach

Actions: Warms the middle; disperses cold; alleviates pain.

Indications:
• Stomach cold: vomiting, diarrhea, abdominal pain.
• Diarrhea (chronic, non-infectious studied) – can be used orally or applied to the navel in a plaster.
• Nephritis: In one study, 10 patients were given two steamed eggs daily into which Hu jiao was placed prior to steaming. All but one patient (who had nephritis for 10 years) were cured.
• A large dose can be used for pain associated with malignancies.
• When prescribed in large doses (up to 30g), it must be cooked at least 2 hours.
• Contains piperine – used as a carrier to increase absorption of other substances through digestive tract (e.g., curcumin) and slow metabolism of certain drugs.
Yoga: Marich: The Sun, named because it contains large amounts of solar energy. Pungent/heating/pungent; K, V-; P+
• Stimulant, expectorant, carminative, febrifuge, anthelmintic.
• Chronic indigestion, toxins in the colon, degenerated metabolism, obesity, sinus congestion, fever, intermittent fever, cold extremities.
• Take nasally in ghee for sinus congestion, headache, seizures.
• Burns up Ama; energizes Agni.
• Good antidote for cold/raw food.
• With honey it is a powerful expectorant and mucus cleanser, dries up secretions.
• Excessive amounts can be an irritant – it is Rajasic in nature.

Dose: 1.5-4.5g

Rou Gui – Inner bark of Vietnamese Cinnamon (Cinnamomum loureirii)

Nature: acrid, hot

Enters: Kidney, Spleen, Heart, Liver

Actions: Tonifies heart fire and kidney Yang; disperses cold to relieve pain; warms, activates, and unblocks the channels; conducts floating Yang back into kidneys; encourages the generation of Qi and blood.

Indications:
• Kidney Yang deficiency, waning at the Ming Men: cold extremities, intolerance of cold, weak lumbar region and knees, impotence, frequent urination.
• Spleen and Kidney Yang deficiency: cold and pain in the epigastrium and abdomen, poor appetite, loose stools.
• Cold-dampness: low back pain, Bi syndrome.
• Failure of the kidneys to grasp the Lung Qi: wheezing.
• Yang deficiency: carbuncles.
• Qi and blood deficiency with cold: ulcers resistant to healing
• Floating Yang: flushed face, severe sweats, wheezing, weak and cold lower extremities, a deficient and rootless pulse (i.e. conditions of (false) heat above, cold below). Also used for other conditions where the upper part of the body is hot (e.g. dry mouth, sore throat, or toothache that become worse at night) and the lower part is cold (e.g. lower back pain, cold lower extremities, diarrhea, weakness in the proximal position of the pulse). To conduct floating Yang back to the kidneys, a tiny dose is used – 0.1 to 0.5g.
• Deep cold causing Qi or blood stasis: cold in the blood causing amenorrhea or dysmenorrhea; yin-type boils (concave, usually ooze a clear fluid), abscesses or sores that do not heal.
• With Qi and blood tonics as an auxiliary herb for chronic deficiency of Qi and blood.
• Injected into BL-13 for asthma. Clinical trials showed it to be very effective.
• Antibacterial and antifungal properties.
• Crush into small pieces before using.
• Weaker than Gui zhi at warming, activating, and unblocking the channels.
• Decoction causes loss of the volatile oils which are responsible for much of its effect. Usually taken directly as a powder, pill, or tincture (can also be added to a strained decoction).
• Recently used to treat blood sugar dysregulation and diabetes.
Yoga: Twak: pungent, sweet, astringent/heating/sweet; Sattvic; V, K-, P+
• Stimulant, diaphoretic, carminative, alterative, expectorant, diuretic, analgesic.
• Colds, sinus congestion, bronchitis, dyspepsia.
• Relieves pain of toothache, and muscular pain.
• Strengthens the heart, promotes Agni.
• Is less likely to aggravate Pitta than ginger is.
• Good general drink for Vata.
Hsu: Vasodilator, diaphoretic, alleviates pain due to GI spasms, inhibits abnormal fermentation processes in intestines.
DY: Supplements the source Qi.
• By supplementing source Qi, it assists in the engenderment of Qi, blood, and essence (as in Shi Quan Da Bu Wan [Ba Zhen Tang + Huang qi and Rou gui]).
• Real Rou gui is very expensive. Many importers sell the culinary quality – Gui pi – which has little medicinal value. It focuses on the middle burner. It does not reinforce kidney Yang or Ming Men fire.
• With Huang lian (3-6g each) to harmonize Yin and Yang, drain the south (heart fire) and supplement the north (kidney Yang), and re-establish the interaction between the heart and kidneys. For indications such as:
– 1. Insomnia, vexation, and agitation due to heart and kidneys not communicating. (Such as for kidney Yang deficiency which cannot move and upbear kidney water, which then becomes dead and stagnant, and fails to nourish heart Yin and control heart fire which rises upward. Use Jiao Tai Wan.)
• As a powder (Rou gui mo or Rou gui mian), some expense can be spared, as it needs only be prescribed at a dose of 1-2g daily, taken directly or added to a decoction within the last 5 minutes of cooking.
Dose: 1.5-4.5g (to conduct floating Yang back to the kidneys, use 0.1-0.5g)

 

Guan Gui: the thinner bark of trees that are 6-7 years old
• This bark has less oil than Rou gui, and is considered to be drier.
• Weaker than Rou gui for supplementing the original Qi, but better for warming the middle and drying dampness. Guan gui is mainly for the middle burner and spleen.
• Less tonifying for Yang Qi than Rou gui.
Dose: 4.5-9g
Rou Gui Xin (Gui Xin): the heart of Rou gui
• This is cinnamon bark which has been cleaned of its fine, superficial layer.
• It is believed to be superior for reinforcing heart Yang and for re-establishing the interaction between the heart and kidneys.

 

Also consider…
Essential Oil of Cinnamon 
K&R: Key for fatigue, weak digestion, weak libido.
• Sympathomimetic, adrenal cortex stimulant, carminative, astringent, antibacterial, oxytocic, antispasmodic.
Earth: flu, parasitosis, digestive mycosis, fatigue after infection, spastic colitis, obsessions, contracts uterus for labor, stimulates sexual appetite, stimulates CNS.
Metal: flu, hemoptysis, melancholy, stimulates psychic functions.
EODR: Cinnamon Bark Essential Oil: anti-inflammatory (COX2 inhibitor), powerfully antibacterial, antiviral, antifungal, anticoagulant, circulatory stimulant, stomach protectant (ulcers), antiparasitic (worms).
• Cardiovascular disease, infectious diseases, viral infections (herpes, others), digestive complaints, ulcers, warts.
• Dilute 1 part essential oil in 4 parts vegetable/seed (fixed) oil; apply 1-2 drops on location.
• May irritate mucus membranes if inhaled undiluted.

Wu Zhu Yu – Evodia fruit / Euodia / Tetradium ruticarpum

Nature: acrid, bitter, hot, slightly toxic

Enters: Liver, Spleen, Stomach, Kidney

Actions: Warms the middle Jiao, disperses cold, relieves pain; stops diarrhea; frees the liver Qi; redirects rebellious Qi, stops vomiting; warms the liver channel and organ; dries dampness; expels damp-cold; leads fire downward (topically).

Indications:
• Yang deficiency cold in the middle Jiao: severe pain in the epigastrium and abdomen.
• Liver and/or stomach channel disorders from cold or phlegm: headaches, epigastric pain, nausea, drooling, reduced taste sensation, pale tongue, wiry or weak pulse.
• Cold in the liver channel: hernial disorders.
• Liver Qi stagnation, Qi rebellion, or Liver attacking the stomach: vomiting, acid reflux, flank pain, severe vertex headache. For liver/stomach disharmony (liver channel heat attacking the stomach), Zuo Jin Wan is commonly used – 6 parts Huang lian with 1 part Wu zhu yu. Indications: hypochondriac pain, indeterminate gnawing hunger, epigastric focal distention, vomiting, acid regurgitation, belching, bitter taste in the mouth, dry mouth, red tongue, yellow coat, wiry, rapid pulse.
• Topical: Grind the herb to a powder. Combine it with water or vinegar (vinegar is stronger) to form a mud. Apply it to the soles of the feet (covering K-1) and cover it with plastic wrap. Put socks on and walk on it for up to 6 hours. This tonifies/warms the kidneys for kidney deficiency; leads fire downward – for rising Yang, mouth or tongue sores, toothache; speeds up metabolism (helps weight loss); lowers blood pressure (in 12-24 hours). This method of application may lose efficacy (particularly for weight loss) after several consecutive treatments.
• Irritable bowel syndrome: powder the herb, mix it with vinegar, and apply it to the navel.
• Useful for early and subacute eczema, childhood eczema, and localized neurodermatitis.
• Antibiotic and antiparasitic effects; analgesic.
• The constitutents evodiamine, evodol, and rutaecarpine are anti-inflammatory via COX-2 enzyme inhibition.
• Very drying. Can injure the Qi. Not for long term use.
• Administering a Gan cao decoction before this herb can reduce its side effects.
• Contains small amount of 5-MeO-DMT (about 0.21% in aerial parts), a powerful psychedelic (also one of the active ingredients [through different plant sources] of the related DMT in Ayahuasca, and toad secretions – e.g., Sonora Desert Toad).
• Some sources claim the correct genus name is Euodia and that Evodia is a misspelling.
Hsu: Constricts the uterus; anthelmintic; antifungal; analgesic; stimulates blood circulation.
• Large doses cause CNS stimulation and hallucinations [probably due to DMT content].
DY: This is one of six medicinals which have been traditionally aged for the purpose of reducing secondary effects and reinforcing their therapeutic actions. Generally, the longer it is kept, the more efficient it becomes.
• With Huang lian to effectively drain liver fire, harmonize the stomach, downbear counterflow, and stop pain, acid regurgitation, and vomiting. For indications such as:
– 1. Lateral costal pain and distention, nausea, vomiting, acid regurgitation, belching, clamoring stomach, and a bitter taste in the mouth due to liver depression transforming into fire which disturbs the stomach. (Zuo Jin Wan)
– 2. Diarrhea and dysentery due to damp-heat.
– The usual dosage for this pair is 3-10g Huang lian and 2-5g Wu zhu yu. Traditionally, the combination is for liver fire causing liver-stomach disharmony which, in turn, leads to nausea, vomiting, and acid regurgitation. In this case Huang lian should be prescribed in a larger quantity and Wu zhu yu in a lesser amount. However, this pair can also be used in patterns where cold and heat are mixed. In this case, if heat is predominant, the dosage of Huang lian should be proportionately more. If there is concomitant stomach Yin deficiency, add Shi hu. If cold is predominant, the dosage of Wu zhu yu should be proportionately more. If there is concomitant Qi deficiency, add Dang shen. If cold and heat are present in identical proportions, the quantities of both herbs should be equal.

Examine.com:

1. Sources and Composition

1.1. Sources

Evodia Rutaecara, the dried unripe fruit of which is also known as Wu zhu yu (Wu Chu Yu, interchangeably) or Evodia Fruit, is a herb used in Traditional Chinese Medicine at doses of 3-9 grams (of the berries) for the purposes of warmth, intestinal comfort (specifically; to alleviate abdominal pain, acid regurgitation, nausea and diarrhea), dysmenorrheal, and fighting inflammation and infections.[1] It is frequently used in a combination supplement called Wu Zhu Yu Tang, which consists of Evodia fruit with Jujube Fruit and Panax Ginseng (1:1:1 ratio) and Ginger root (twice the amount of any one other ingredient) which is a decoction used for hypertension or as Zuo jin wan which is used for gastrointestinal distress alongside Rhizoma Coptidis at a 1:6 ratio (Evodia:Coptidis). Another decoction exists called Fan zuo jin wan, which is Rhizome Coptidis and Evodia in the inverse ratio.

When consuming Wu Zhu Yu Tang in a traditional manner, the estimated intake of Rutaecarpine is 16mg daily (extrapolated from the average intake of 9g berry extract taken thrice a day) and slightly higher levels of evodiamine.[2][3]

Traditionally eaten when you are cold; apparently warms you up real nicely while making your stomach and intestines happy. Also supposedly fights cancer

1.2. Composition

  • Evodiamine[4] and dehydroevodiamine, two forms of one of the main compounds belong to the ‘quinazolinocarboline alkaloid’ class [5] Evodiamine is found in the range of 0.2-1.6%, with the lower range of the samples tending to have more dehydroevodiamine (0.12-0.86%), suggesting interconversion[6]
  • Rutaecarpine and its metabolite 10-hydroxyrutaecarpine (as well as the former’s glycoside, rutaecarpine-10-O-rutinoside[7]) the forms of the other main quinazolinocarboline alkaloid.[5] Rutaecarpine is at around 0.15-0.55% in evodia fruit.[6]
  • Other quinazolinocarboline alkaloids such as wuchuyine and rhetsinine[8][9] and Evodiamide, which is at around 0.005-0.08% usually, although some plants have been noted as high as 0.4-0.6%[6]
  • The quinoline alkaloids Evocarpine, Dihydroevocarpine, 1-methyl-2-n-nonyl-4(1H)quinolone[5] as well as a large amount (17+) of others[10]
  • Wuzhuyuamide-I[7] at low levels (0.00003%)[11] and Wuzhuyuamide-II, two similarly structured compounds to evodiamine and rutaecarpine[12]
  • Flavonoids and flavonoid glycosides such as isorhamnetin-7-O-rutinoside and diosmetin-7-O-?-d-glucopyranoside[5]
  • Acylgluconic acids such as trans-feruloylgluconic acid and trans-caffeoylgluconic acid[11] at 0.00003% and 0.0006% whole fruit, respectively (although can be isolated in a methane-ethanol extraction)[11]
  • Limonoid compounds such as Limonin[13] (not to be confused with Limonene) as well as evodirutaenin, evodol, and shihulimonin A[14]
  • Myo-Inositol[11] at 8g per 299.5g sample (2%)[11]
  • Pthalic acid dibutyl ester at 8mg per 299.5g (miniscule)[11]
  • Essential oils of ?-pinene (72.82%), 1R-?-pinene (8.90%), and ?-myrcene (1.99%)[15]

Despite the similarities in action to Capsaicin, which is hot pepper extract; isolated evodiamine possesses no significant taste nor spiciness. A large amount of crystal data for evodiamine can be found here.[4]

2. Pharmacology

2.1. Serum values

After oral administration of a Wu zhu yu decoction (Evodia, Panax Ginseng, and Jujubae Fructus at a 1:1:1 ratio, and Ginger at twice the amount of any one ingredient; ethanolic extract) given at 12g/kg orally (2.4g/kg Evodia ethanolic extract) the following parameters were found for various compounds in Evodia Rutaecarpa.[5]

  • Evodiamine had a half-life of 0.93 ± 0.45 hours, a Tmax of 1.49 ± 0.22 hours, a Cmax of 19.52 ± 8.17ug/mL, and an AUC of 71.27 ± 15.52ug/h/mL.[5] Another study finding a Cmax of 49 ± 19ng/mL after 500mg/kg ingestion evodiamine in isolation,[17] along with the former pinpoint a bioavailability of pure evodiamine at around 0.1% in isolation and slightly higher as Evodia Rutaecarpa. Another study using basic Evodia ethanolic extract found that 40mg/kg of an extract (35% evodiamine by weight, so 14mg/kg) conferred a Cmax of 164.8 ± 65.1ug/mL;[18] relative to the previous study, this suggests that a dose of 35.7-fold lower, if taken in an ethanolic berry extract, has an average peak blood concentration 3.36-fold higher. The Tmax in all studies seems to hover between 30-60 minutes, however.[17][18][5]
  • Rutaecarpine had a half-life of 0.98 ± 0.39 hours, a Tmax of 1.26 ± 0.23 hours, a Cmax of 13.46 ± 7.03ug/mL, and an AUC of 62.44 ± 18.85ug/h/mL.[5] Another study found low bioavailability of Rutaecarpine in isolation (Concentration of 2.4 ± 3.0ng/ml 30 minutes after 40mg/kg crude drug[19]) but administering Rutaecarpine as a solid dispersion (mechanical technique) increased the concentration in the blood 7.5-fold (to 18.1 ± 1.8ng/mL[19]) Nanoemulsions have also shown benefit in increasing the absorption rates.[20] A basic concentration ethanolic extract of Wu Chu Yu (pre-ripe) berries (40% of a 40mg/kg oral ingestion, so 16mg/kg), reaches blood levels of 215.3 ± 80.4ug/mL in rats.[18] The improvement in bioavailability is similar to that seem with evodiamine, where an oral dose 2.5-fold lower can have a blood concentration 89.7-fold higher if consumed in the form of a concentrated berry ethanolic extract. Similar to evodiamine, Tmax of all studies hovered around 30-60 minutes regardless of the Cmax.[5][19][18]
  • Dehydroevodiamine had a half life of 0.79 ± 0.21 hours, a Tmax of 1.07 ± 0.15 hours, a Cmax of 7.64 ± 0.63ug/mL, and an AUC of 12.39 ± 2.71ug/h/mL.[5] In isolation, dehydroevodiamine appears to have better bioavailability than the previous two molecules (averaged at 15.35% in rats[9]) yet at least one study has investigated Dehydroevodiamine and its circulating levels in conjunction with other plants, and consumption of Evodia alongside Rhizoma Coptidis (1:6 ratio, combination known as Zuojinwan) appears to preserve the Tmax (1.6 hours without, 1.8 hours as Zuojinwan) yet elevate the Cmax 2.66-fold (15,383 ± 7166 to 40,992 ± 21,052) while reducing the Tmax (3.5 ± 3.0 hours to 1.5 ± 1.1) and causing a large increase in the AUC to infinity by 174% (68,134 ± 19,162 to 186,715 ± 39,211).[21]

The three main components of Evodia Rutaecarpa all appear to be highly subject to herb-herb interactions, where their absorption and circulating levels are much higher when in the form of the whole plant rather than isolated chemical and even higher when paired in Traditional Chinese Medicine decoctions. It may be worthless to supplement evodiamine or rutacarpine in isolation if your goal is to get it to your blood (fine if you want it in the colon) due to poor bioavailability

  • 10-hydroxyrutaecarpine had a Cmax of 0.76 ± 0.16ug/mL and a Tmax of 0.50 ± 0.25 with an AUC of 9.32 ± 2.93ug/h/mL, but an undetectable half-life.[5]
  • 1-methyl-2-n-nonyl-4(1H)quinolone had a Cmax of 3.16 ± 1.28ug/mL at a Tmax of 0.77 ± 0.15 hours, its AUC was 9.83 ± 1.51ug/h/mL and half-life was 2.18 ± 0.47 hours.[5]
  • Evocarpine had a half-life of 0.53 ± 0.18 hours and a Tmax of 0.88 ± 0.17 hours, with a Cmax of 11.53 ± 6.97ug/mL and an AUC of 33.66 ± 10.52ug/h/mL.[5]
  • Dihydroevocarpine had a half-life of 0.49 ± 0.21 hours and a Tmax of 0.79 ± 0.15 hours, a Cmax of 6.05 ± 2.87ug/mL and an AUC of 16.53 ± 5.79ug/h/mL.[5]
  • Isorhamnetin-7-O-rutinoside had a half-life of 0.67 ± 0.30 hours, a Tmax of 0.95 ± 0.25 hours, a Cmax of 2.21 ± 0.32ug/mL, and an AUC of 7.54 ± 1.03ug/h/mL.[5]
  • Diosmetin-7-O-?-d-glucopyranoside had a half-life of 0.95 ± 0.51 hours, a Tmax of 1.53 ± 0.17 hours, a Cmax of 1.73 ± 0.51ug/mL, and an AUC of 9.41 ± 3.57ug/h/mL.[5]

In general, all compounds tend to have low to moderate bioavailability and relatively rapid pharmacokinetic profiles; hitting their peak concentrations in the blood before or at an hour after administration. Evodiamine and Rutaecarpine seem to really benefit from being ingested as a whole berry rather than isolated compounds

2.2. Systemic Distrubution

Evodiamine appears to be carried in the blood and distributed into organs, and one study in rats found the volume of distribution to be 560ml/kg[22] and found evodiamine (and metabolites) to be deposited in the liver, kidneys, heart, lung, and adipose tissue at a concentration higher than plasma, and other tissues it diffused in were at lower levels relative to plasma.[22]

2.3. Brain Distribution

When investigating dehydroevodiamine, it has been demonstrated that this molecule can cross the blood brain barrier of the rat and enter the brain via linear kinetics.[23] When a plasma level of 4.82 ± 1.55 ?g/mL was measured in rats, the concentrations in the brain were 1.11 ± 0.4 (cortex), 0.93 ± 0.24 (hippocampus), 0.64 ± 0.28 (striatum), 1.13 ± 0.33 (cerebellum), 1.04 ± 0.3 (brain stem), and 1.18 ± 0.18 ?g/g (everything else).[9] On average, concentrations of dehydroevodiamine that circulate in the brain are 3-4x lower than plasma levels.[9]

2.4. Metabolism and Enzymatic Interactions

Dehydroevodiamine appears to be subject to P450, and its circulating metabolites consist of five glucuronides (two identified ones at the 10 and 11 carbon) and one sulfate (Dehydroevodiamine-12-sulfate) in freely moving rats.[9]

Rutaecarpine is metabolites mostly by cytochrome P450 1A2 (aromatase) at the 10, 11, and 12 carbon positions, although 3 is not unheard of[24][25] and into the four metabolites of 3, 10, 11, or 12-hydroxyrutaecarpine.[26] Metabolism into 3- and 10- hydroxyrutaecarpine is strongly inhibited by ketoconazole, suggesting it is metabolized by CYP3A4; the other two metabolites (11- and 12-hydroxyrutaecarpine) are metabolized by CYP1A but can also be metabolized by CYP3A4 and CYP2D6.[3]

Interestingly, Rutaecarpine’s metabolite 10-hydroxyrutaecarpine, which is produced by CYP3A4, can act as an aromatase inhibitor, inhibiting CYP1A1 and CYP1A2 (two aromatase isomers) with IC50 values of 2.56 ± 0.04uM and 2.57 ± 0.11uM, respectively.[3] Rutaecarpine also shares aromatase inhibitory potential with preference for CYP1A2,[27] but prolonged (3 days) ingestion of rutaecarpine,[28] Evodia,[2] or a Wu Zhu Yu Tang mixture of which effects are attributable to Evodia[2] may cause CYP1A induction and thus the opposite effects of inhibition.

Rutaecarpine technically is an aromatase inhibitor, but causes increased aromatase activity relatively quickly

CYP1B1 is also inhibited by 10-HRT at 0.09 ± 0.01uM.[3] CYP3A4 seems to be unaffected by rutaecarpine.[28]

2.5. Excretion

24 hours after administration of evodiamine, 82% of evodiamine and its metabolites are excreted with 23% of that excretion occuring via the urine and the rest via feces.[22]

After an oral bolus of 500mg/kg bodyweight dehydroevodiamine, most of it is conjugated by P450; the amount of unchanged metabolite in the urine and feces are 0.5% and 6% of the initial oral dose, respectively.[9]

Rutaecarpine has a large amount of fecal excretion (~42%) after oral ingestion, and its main urinary metabolite is 10-hydroxyrutaecarpine, which is the result after rutaecarpine interacts with the CYP1A2 enzyme.[26]

3. Mechanisms of Action

3.1. Vanilloid Receptors

Evodiamine is an agonist of the vanilloid receptor,[29] a property also seen with the red pepper extract Capsaicin. It appears to be slightly less potent than capsaicin, requiring thrice the concentration in vitro to maximally stimulate the receptors.[29][30]

Through interactions with vanilloid receptors, Evodia Rutacarpa possesses antinocioreceptive (pain relieving) effects.[31]

4. Interactions with Fat Mass and Obesity

4.1. Thermogenesis

Evodia Rutacarpa has been investigated for its effects on body fat due to it being used traditionally as a warming agent and as a ‘hot herb’; references to thermogenesis in the Chinese literature.

1-3mg/kg bodyweight evodiamine administered subcutaneously was able to drop core body temperature by 1C in fasted mice, while fed mice required 10mg/kg to achieve the same effect.[32] These drops in internal temperature were matched with extra heat dissipation from the rat tail, indicative of thermogensis, almost immediately.[32] The ability of evodiamine’s mechanisms of action, TRPV1 activation, to make areas tolerant to the cold is also a possibility; cold hyposensitivty (responding less to the cold) indirectly increases perceptions of heat.[33]

This heat production, however, is not the sole reason for evodiamine’s fat burning effects.[34]

Evodiamine has been traditionally used to increase warmth, and it appears it might increase both heat production and reduce the perception of cold. However, the studies from which this data is drawn are not suited to human oral consumption of Evodia

4.2. Effects in adipocytes

When incubated in preadipocytes, evodiamine is able to activate the MAPK cascade, which reduces insulin-induced phosphorylation of Akt and also PPAR? activity, which thus decreases preadipocyte differentiation.[34] The classical mechanisms of evodiamine, as agonist of TRPV1 receptors,[35] can also work to reduce preadipocyte differentitation;[36] thus there may be two similar mechanisms of action occurring.

Inhibition of preadipocyte differentiation has been noted elsewhere relatively dose-dependently, but most significantly at 4uM concentration or above[37] and in vivo following injections of evodiamine.[38] The authors mentioned this was ‘negative crosstalk’ with insulin signalling, which interferes with its effects.[34]

Evodiamine appears to exert anti-obesity effects via inhibiting preadipocyte differentiation

4.3. Interventions

One study on mice fed 0.03% evodiamine and rats fed 1.35% evodia extract (standardized to 0.02% evodiamine) in their obesity causing diets over 21 days showed no difference in food intake compared to control (important to note, as the adverse taste of Capsaicin screws with food intake in animal studies) but a small reduction in fat mass on mice (28% reduction of perirenal fat, 11% less epididymal fat) and decreases in weight (-10.3% relative to control) and increased thermogenesis; suggesting evodiamine may exert an anti-obesity effect.[32] Another study investigating mechanisms fed 0.03% evodiamine for 6 months and noted significant anti-obesity effects by reducing the rate of weight gain, and this persisted in UCP1 knockout mice who were unable to produce heat from evodiamine.[34]

Evodiamine has been shown to prevent fat gain to a degree in mice fed a diet that induces fat gain, but has not yet been demonstrated to induce fat loss. The heat producing effects of evodiamine may not be related to attenuation of fat gain

5. Interactions with Inflammation

5.1. Endothelium

When evodiamine is incubated with endothelial cells, it is able to inhibit IL-1? (at 10uM) and Thromboxane B2 (TXB2) secretion (at 10uM) in response to inflammatory signals (LPS) and was able to decrease the levels of E-selectin on endothelial cells; although no response was dose-dependent.[39]

5.2. Macrophages

Both evodiamine and rutaecarpine have been shown to inhibit PGE(2) production in macrophages that are stimulated by LPS (a pro-inflammatory signal)[40] and in macrophages undergoing hypoxia.[41] Evodiamine was further able to prevent upregulation of COX-2, a pro-inflammatory enzyme, while rutaecarpine was ineffective at doing so.[40] Dehydroevodiamine can also reduce COX-2 activity and mRNA translation[42] while rutaecarpine seems to be more of a direct inhibitor rather than manipulating protein content of COX enzymes, able to inhibit both COX-1 and COX-2 with IC50 values of 8.7uM and 0.28uM, respectively.[43]

Another compound, goshuyuamide II, was demonstrated to be able to inhibit 5-LOX and reduce synthesis of leukotrienes.[40]

5.3. Cytosolic Signalling

The combination decoction of Evodia Fructae and Coptidis Chinensis 1:6 (Zuo Jin Wan) has been shown in vitro to inhibit both nF-kB translocation and AP-1 signalling in HepG2 (liver) cells with IC50 values of >200 and 22.9?g/ml for AP-1 and nF-kB, respectively for the combination.[15] Berberine was able to inhibit AP-1 and nF-kB with IC50 values of 9.5 and 50?M, respectively, while Evodiamine was only inhibitory on AP-1, and to lesser potency than Berberine.[15]

Evodiamine has been shown to inhibit nF-kB activation in macrophages at 1-10uM concentration in response to pro-inflammatory signals.[40]

6. Interactions with Cancer

6.1. Topoisomerase Inhibition

Topoisomerases (I and II) are enzymes that regulate the separating of DNA strands so DNA can be replicated. DNA gets unwound when a phenolic nucleophile attacks the 3′ end of DNA, causing it to bind to Tyr723 on the TopoI enzyme, which allows DNA to unwind and relax; it is eventually then attacked by the 5′ end of the DNA and the two ends reunite in a process called religation. Topoisomerase I basically holds the 3′ end for a bit while DNA gets replicated.[44] Topoisomerase I inhibitors can prevent DNA from religating, and induce cytotoxicity (cell death); which is actually a good idea for cancer cells that overexpress Topoisomerase I as they die much faster than regular cells.

Evodiamine has an IC50 value of 6.02uM in MCF-7 breast cancer cells, which express high levels of Topoisomerase I, and only slightly less cytotoxic than Camptothecin which is a research standard drug.[45] Evodiamine is able to prevent DNA religation in a concentration-dependent manner in a similar manner to Camptothecin, by making a complex with Topoisomerase I and the 3′ DNA strand it holds.[45] Evodiamine has demonstrated cytotoxixity in breast cancer cells elsewhere[46] and was shown in adriamycin-resistant breast cancer cells to induce cell death both in vitro and in vivo with a potency greater than that of paclitaxel.[47]

Evodiamine is a dual catalytic topoisomerase I and II inhibitor,[48] and shows efficacy against some cells that are resistant to the more potent topoisomerase I inhibitor Camptothecin,[48] and does not seem to induce DNA damage.[48] A flavanoid from evodiamine also possesses dual inhibitory potential.[46]

A mechanism by which Evodia Fructs may be anti-cancer; awaits more studies to see its overall clinical relevance, but its dual inhibition is novel and promising at least

6.2. Apoptosis

Apoptosis, or the event of cell death, is an important biomarker in cancer therapy.

Evodia components have been demonstrated to induce apoptosis in gastric cancer cells (SGC-7901)[49][50][51] and (N-87),[10] Breast cancer cells (MCF-7)[52][46][45] and (NCI/ADR-RES),[53] Liver cells (HepG2),[10][54] Leukemia cells (HL-60)[10] (THP-1)[52] and (U937),[55] Lung (H-460)[10] and (LLC),[56] Colon (COLO-205),[57][58] Thyroid (ARO),[59] Melanoma (A375-S2),[60][61][52][62] and (B16-F10),[56] Cervical Cancer (HeLa),[63][52] fibrosarcoma (L929),[52] and has been demonstrated in vivo to inhibition the Sarcoma-180 tumor model when fed as the decoction Zuo jin wan.[64][65] More often than not, these effects are attributed to Evodiamine and its metabolites although in some instances flavanoid glycosides are to credit.

7. Nutrient-Nutrient Interactions

7.1. Caffeine

When rutaecarpine (active indole in Evodia) is fed to rats, the AUC and Cmax values of Caffeine are significantly reduced; meaning rutaecarpine can reduce the exposure of caffeine to the body.[66][67] This also extends to the similar xanthine compound theophylline.[68] These effects extend to consumption of Evodia itself, and combination decoctions such as Wu Chu Yu-Tang.[67]

This effect is rather significant; pretreatment of 80mg/kg oral Rutaecarpine daily for 3 days (a high dose, but its bioavailability is unaugmented) in rats reduced the Cmax to 31% of the control group, the Tmax to 22%, the AUC to 5% of control, and reduced the half-life from 0.73+/-0.07 hours to 0.27+/-0.1 hours.[66] Similar trends were seen for all metabolites of caffeine (paraxanthine, theophylline, theobromine)

Rutaecarpine is able to induce (increase) activity of various hepatic enzymes such as CYP1A2, CYP2B, and CYP2E1;[28][69] CYP2E1 induction is seen at 80mg/kg oral ingestion in rats while only 20mg/kg is needed for CYP1A2.[67] As Caffeine is highly metabolized by CYP1A and CYP2E1, their increased activity causes greater metabolism of caffeine in a shorter time frame and thus limits systemic exposure.

Rutaecarpine appears to potently suppress the circulating levels of caffeine via increasing hepatic and intestinal degradation; a highly antagonistic compound

7.2. Rhizoma Coptidis

The pair of Evodia fruit and Rhizoma Coptidis (rhizome of Coptis chinensis) is known as Zuo jin wan and is a Traditional Chinese Medicine decoction for gastrointestinal distress. It is paired with 6 parts Rhizoma Coptidis to 1 part Evodia Fructus (6:1 ratio). Conversely, reversing the ratio and favoring Evodia in the 6:1 ratio is the basis for Fan zuo jin wan, another Chinese decoction.[70]

Coptis and Evodia form a dichotomy of cold and hot (Yin and Yang), respectively, where Coptis reportedly induces a cold state and a seeking process for a warm environment while Evodia induces heat and the seeking behavior for a cold environment.[71] Coptis seems to be able to reduce internal body temperature and oxygen consumption in mice and prolong time spent in a warm environment (as assessed by warm pads) while Evodia increases time in a cold environment, and increases both oxygen consumption and body temperature.[71] Zuo jin wan is classified as cold whereas Fan zuo jin wan is classified as warm.[70][71] The only currently known biomarker for this temperature preference is liver ATPase activity.[72][73]

Coptis Chinensis and Evodia Fructus appear to be mostly antagonist to each other in how they are seen to affect temperature; yet they are used together in decoctions and mixtures (some Yin Yang stuff I guess). The historical reports of Evodia’s ‘heat’ and Coptis’s ‘cold’ properties actually do seem to have some merit, as evidenced by the rat preference tests trying to bioregulate their temperature

When looking at the pharmacokinetics of the combination, Rhizoma Coptidis appears to benefit the pharmacokinetics and circulating levels of some bioactives in Evodia such as dehydroevodiamine[21] by about 274% of the value of Evodia alone despite the same oral dosage (AUC value).[74] Evodia seems to either not significantly affect the pharmacokinetics of some Coptidis molecules such as coptisine (acutely)[21] yet increase general absorption[75] but can reduce the AUC of various alkaloids (coptisine, palmatine, jateorrhizine) after prolonged ingestion and reduce the AUC and Cmax values of the Berberine content of Coptidis Rhizoma either chronically[75] or acutely.[74] This was hypothesized to be secondary to Evodia Fructus pretreatment enhancing the expression of hepatic UGT1A1, a sulfation enzyme, which conjugated compounds in Coptidis Rhizoma.[75]

Coptidis chinensis rhizome enhances the bioavailability and circulating amount of co-ingested Evodia fruit, but Evodia fruit hinders the absorption and circulating amount of the active ingredients of Coptidis Chinensis; almost as if the former is sacrificing itself for the latter

7.3. Paeoniflorin

Paeoniflorin is the main bioactive found in the herb Paeonia Lactiflora, and its bioavailability and circulating amounts are enhanced by various herbs. Although not to the same degree of Fennel fruit (which increases bioavailability to 226.02% of the level of Paeoniflorin in isolation), consumption of Paeoniflorin alongside Evodia fruit elevates relative absorption to 123.62%.[76]

Paeonia Lactiflora doesn’t do much for Evodia, but Evodia enhances the absorption of Paeonia Lactiflora bioactives

Dose: 3-9g

Xi Xin – Asarum root – Often referred to as “Wild Ginger,” though unrelated to ginger – “Thin Acrid”

Nature: acrid, warm, slightly toxic

Enters: Lung, Kidney

Actions: Alleviates pain; releases the exterior, eliminates wind, disperses cold; warms the Lungs, resolves harmful fluid, transforms phlegm; opens the nose; mildly promotes sweating.

Indications:
• Wind-cold or any exterior cold pattern, especially with the addition of dampness or underlying Yang deficiency: headache (especially Shaoyin, radiating to the teeth), toothache, body aches, Bi syndrome, other pain.
• Cold and harmful fluid in the Lungs: cough with thin, whitish sputum, difficulty breathing.
• Nasal congestion – various types.
Shaoyin syndrome, fever, deep pulse.
• Topical: in powder, mixed with water and glycerine, and applied to the navel (for at least 3 days) for oral lesions.
• Better at warming the interior than releasing the exterior.
• For nasal and oral problems, it is often powdered and sucked directly into the affected areas.
• Antipyretic; analgesic.
• Liu: Can be used in doses as high as 10g daily for body aches. Monitor the patient for signs of toxicity – not for prolonged use at higher doses.
• Bensky/Gamble classifies this herb with acrid warm herbs that release the exterior.
• Contains aristolochic acid in aerial parts. Use only the root

• Caution in patients with renal problems. May be restricted by FDA.
Hsu: Local anesthetic, analgesic; antitussive.
DY: Powerful analgesic. Despite its warm quality, it can be combined with appropriate herbs for any pain pattern.
• Toxic at doses over 5g per day.
IBIS: Carminative, diaphoretic.
• Avoid in stomach inflammation and/or intestinal inflammation due to its spicy stimulant effects (Brinker).
• Avoid during pregnancy due to its emmenogogue and abortifacient effects (Lewis & Elvin).

Dose: 1-3g

Notes on This Category

Commonly combined with:
• A. Herbs that promote Qi circulation.
• B. Herbs that warm the interior, when there is interior cold associated.
• C. Herbs that transform dampness, when there is dampness in the middle Jiao.
• D. Herbs that clear heat when there is heat associated. (Lian qiao is most commonly used.)
• E. Herbs that tonify the spleen and stomach when there is deficiency of either organ.

Gu Ya – Rice sprout – Oryza

Nature: sweet, neutral

Enters: Spleen, Stomach

Actions: Promotes digestion (mainly of starch); adjusts the middle Jiao; slightly tonifies the spleen and stomach; promotes the appetite.

Indications:
• Food retention, including when due to spleen or stomach deficiency: indigestion – especially with accumulation of undigested starchy foods (contains amylase). Also appropriate in cases of hot food stagnation.
• Spleen or stomach deficiency: poor appetite, weak digestion.
• Will not damage stomach Qi – very safe.
• The raw form is mainly used to aid digestion.
• The dry-fried form is stronger at tonifying the stomach and spleen.
• This herb’s potency is greatly diminished by cooking or prolonged toasting. It is best taken powdered and added to a prepared decoction.

Dose: 9-15g

Ji Nei Jin – Chicken Gizzard Lining – “Chicken Inner Gold”

Nature: sweet, neutral

Enters: Spleen, Stomach, Small Intestine, Bladder

Actions: Slightly strengthens the spleen; promotes digestion; strongly eliminates food retention; controls Jing and urine; transforms hardness and dissolves stones.

Indications:
• Food retention: malnutrition in children or distention of the epigastrium, poor appetite. Can be used alone in mild cases of food retention.
• Seminal emission, incontinence, enuresis, frequent urination. Especially for children.
• Stones in the urinary or biliary tract.
• Usually considered more effective when taken directly as a powder.
• Note: this herb is often heat treated before entering the United States (presumably due to concerns about bird flu or other contaminants). If the herb derives its potency in part from ventriculin and digestive enzymes, this heat treatment may damage these substances and reduce its efficacy. You could theoretically make your own from domestic chickens.
Hsu: Increases gastric secretions, promotes motor activity in the stomach, increases the rate of expelling air, stimulates the nerves and muscles of the GI tract.
DY: Frees strangury.
• With Hai jin sha to free strangury, transform stones, and, therefore, treat stone strangury. For stone strangury and urinary lithiasis due to damp-heat. This combination can be reinforced by combining it with Jin qian cao, Hua shi, Qu mai, and Che qian zi.
• With Mang xiao to strongly and effectively soften hardness, disperse accumulation, clear heat, and transform stones. For renal, urethral, or bladder lithiasis. Neither substance should be cooked. For greatest efficacy, the two herbs should be ground to a powder (6-10g Ji nei jin and 3-10g Mang xiao) and taken, 6g at a time, twice daily, dissolved in hot water.
SD: Jineijin is the inner lining of the chicken gizzard, which has a yellowish-gold color (ji = chicken; nei = inner; jin = gold). This substance has been in use for about 2,000 years, and was mentioned, along with other parts of the chicken also used medicinally, in the Shennong Bencao Jing (ca. 100 A.D.). At that time, jineijin was described as a treatment for diarrhea (1). Later, it developed a reputation for promoting digestion and astringing fluid discharge, which are therapeutic approaches used in the treatment of diarrhea, but these can also be applied to alleviating nausea, vomiting, and indigestion, as well as astringing excess urination, seminal emission, or leukorrhea. The claimed digestion promoting effect has been broadened to indicate that jineijin aids not only meat digestion, which was one of the early attributions, but also digestion of grains, and it is said to alleviate chronic digestive disorders, such as stomach ulcers, atrophic gastritis, and stomach prolapse. An additional property was attributed to jineijin: breaking down masses, being used for any kind of stagnation in the internal organs, for lower abdominal masses in women, for gallstones and kidney stones, and for tumors.
Its digestion-promoting activity has been the primary focus of its use in traditional Chinese medicine. As described by Yang Yifan (2); “Jineijin not only reduces the stagnation of meat, but also aids digestion of all other kinds of food. Its action in relieving food stagnation is quite strong and it is very effective in treating fullness in the stomach, nausea, vomiting, and diarrhea.” According to the famous physician Jaio Shude (3): “Jineijin primarily disperses food…used to fortify the spleen and open the stomach, disperse water and grain, and assist movement and transformation.” The Advanced Textbook on Traditional Chinese Medicine and Pharmacology (4) notes that jineijin “is effective for treating dyspepsia, food stasis, and infantile malnutrition…for spleen dysfunction in transformation and transportation marked by loss of appetite.” In comparing jineijin with other substances used for promoting digestion, this text indicates that it has a “strong effect.”
VENTRICULIN
The gizzard lining has trace amounts of digestive enzymes in it, but these cannot be a major source of the action of this substance. In our digestive process, there is a release of digestive juices with enzymes in quantities far higher than one would obtain from jineijin. The active component that has been isolated from the gizzard lining is called ventriculin. This substance was used in modern medicine during the early 20th century, at which time it was derived from hog stomachs. It had been primarily prescribed as a treatment of pernicious anemia, a condition which often resulted from poor absorption of vitamin B12, and for atrophic gastritis (also called chronic gastritis), one of the main causes of pernicious anemia in adults. Ventriculin was later replaced by other drugs.
Ventriculin was developed into a drug at the Simpson Memorial Institute for Medical Research, a center at the University of Michigan opened in 1926 and specifically created to identify a cure for pernicious anemia. At that time pernicious anemia had become a serious problem, with a particularly high rate in Michigan. The money to set up this center was donated in 1924 by a leader in the iron industry, Thomas Simpson, who suffered from this disease, which was incurable and deadly. Even before a director could be appointed, a treatment for pernicious anemia was identified in 1926 through research at other laboratories, for which the discoverers were awarded the Nobel Prize in 1934. That treatment involved consumption of massive quantities of liver extract.
Dr. Cyrus Sturgis was appointed as inaugural director of the Simpson Institute, and his research in 1929 led to the development of Ventriculin. This substance may have functioned by two mechanisms: providing a missing intrinsic factor secreted by the stomach lining that is needed for B12 absorption and stimulating secretion of gastric acid and digestive enzymes, such as pepsin, which help release essential nutrients from food, including vitamin B12. The University arranged with Parke-Davis, a Michigan company that had opened a factory in Detroit during the 1870s, to produce the drug. Later, it was determined that atrophic gastritis was primarily caused by H. pylori bacterial infection or an autoimmune disorder, leading to other approaches to therapy. In relation to the use of jineijin for digestive weakness, the potential for ventriculin to stimulate the secretion of gastric digestive substances is the main area of interest.
According to Chinese studies, as relayed in the summary book Pharmacology and Applications of Chinese Materia Medica (5), a large dose of jineijin could even affect people with normal digestion:
45-60 minutes following ingestion of the roasted jineijin powder (5 g) in healthy individuals, the gastric secretion was increased by 30-37% compared with the control group; two hours later the condition was normalized. The acidity of the gastric juice was also greatly increased. The free acid and total acid generally began to rise 1 hour after the medication, peaking in 1-2 hours; the condition was gradually restored to normal after 3 hours….The onset of the incremental effect on the digestive juices was slow, but the effect was prolonged. Gastric motility was also markedly increased as shown by the prolongation of peristalsis and accentuation of peristaltic waves, resulting in rapid emptying of the stomach. Since jineijin itself contains only a very small amount of pepsin and amylase, the increase of gastric secretion and motility following medication was believed to be due to stimulation of the gastric neuromuscular receptors as mediated by the humoral factor.
The research cited above was from 1963, and there have been few detailed studies since. According to a 1973 clinical report relayed in the same summary, it was noted that jineijin (usually as an ingredient in an herbal formula) “was especially suitable for dyspepsia and gastric discomfort due to insufficient digestive enzymes. It reduced abdominal distention, abnormal intestinal fermentation, halitosis, and mushy stool, etc.” In a 1975 report, one researcher considered that the mechanism of action was mainly due to increased gastric secretion promoted by ventriculin.
Although roasting is a common process for preparing jineijin, roasting likely damages some of the ventriculin, so using the raw material may be superior. The original purpose for roasting it was to enhance the treatment of diarrhea. Roasted herbs, with ginger and atractylodes as typical examples, are commonly used for that purpose. Roasting produces adsorption sites in carbon-based materials to bind up fluids, bacteria, and toxins; this is the same reason that activated charcoal is used for treatment of diarrhea. Roasting isn’t a required step for promoting secretion of digestive fluids.
The absence of significant amounts of digestive enzymes in jineijin is also the case with commonly used Chinese herbs employed for treating indigestion, such as crataegus, raphanus, atractylodes, and citrus. Sprouted barley (maiya) does contain some amylase (for breaking down starch). This is a heat-labile enzyme, so that decocting maiya reduces the amylase activity by one-third compared to using just the powdered herb; it is reduced by half again if the herb is roasted as is often done in China. A study conducted in 1964 (5) suggested that maiya “mildly promoted the secretion of gastric acid and pepsin in humans. Mild cases of indigestion could be treated with a decoction of 9-15 grams of the herb.” The fermented wheat or barley product called shen-chu (shenqu) also contains some protease and amylase derived from the yeast fermentation, and the situation is similar: a substantial dose in decoction form is needed to treat mild indigestion.
The potential benefits to having additional digestive enzymes-particularly at a higher level than available through Chinese herbs for treating cases of indigestion-is evident. Modern technology makes it possible to get a sufficient amount of these enzymes in a small volume, such as in a capsule or tablet. These substances can be obtained from fungal/yeast, plant, or animal sources and are then concentrated to varying extents. Enzyme supplements have become a popular method of therapy.

Dose: 3-9g (1.5-3g directly as powder)

Lai Fu Zi – Radish seed – Raphanus

Nature: acrid, sweet, (maybe bitter), neutral

Enters: Spleen, Stomach, Lung

Actions: Descends the Lung Qi; resolves phlegm; promotes digestion, eliminates food retention; slight function to promote bowel movement.

Indications:
• Food retention: bloating, fullness, distended epigastrium and abdomen, belching with fetid odor, acid regurgitation, abdominal pain, or diarrhea with hesitant elimination.
• Food retention leading to dampness/phlegm in the Lungs: coughing, wheezing.
• Lung phlegm accumulation: cough with copious sputum.
• The raw form is used for food stagnation.
• The dry-fried form is used for productive coughs.
• The fried form is used for promoting bowel movement.
• Antimicrobial, antifungal properties.
• Reduces serum triglycerides.
• Compared to Su zi and Bai jie zi: All are capable of transforming phlegm, regulating the Qi, and alleviating wheezing. However, Bai jie zi warms the Lung Qi, Lai fu zi disperses the Lung Qi, and Su zi descends the Lung Qi.
JTCM: For abdominal distention after surgery: fry 200g Lai fu zi, grind to a powder, wrap in cloth or a tea bag, heat it, and apply it to the navel until the distention abates (can also apply a TDP lamp to keep the bag hot).
• For eczema and prevention of viral and fungal growths: fry the herb for 30 minutes, let it cool, grind it to a powder, mix it with vinegar, and apply it topically once a day.
PLB: For respiratory conditions with phlegm (allergies, asthma, etc.) which are exacerbated by food sensitivities.
Hsu: Antibacterial, antifungal, stomachic, expectorant.

Dose: 6-12g

Mai Ya – Barley sprout

Nature: sweet, neutral (warm if fried)

Enters: Spleen, Stomach, Liver

Actions: Promotes digestion (mainly of starch); mildly frees the flow of liver Qi; adjusts the middle Jiao; strengthens the stomach and spleen; inhibits lactation.

Indications:
• Food retention: distended epigastrium and abdomen, poor appetite. Particularly useful for over-consumption of starch and for cold food stagnation. Also for poorly-digested milk in infants.
• To stop nursing or for stagnant milk with distending pain in the breasts, use a large dose (to 60g).
• Liver Qi stagnation: stifling sensation and distention in the epigastrium or costal region, belching, poor appetite.
• Spleen deficiency: weak digestion, poor appetite.
• Treats hepatitis, especially acute.
• When using herbs which strongly subdue the liver, add a small amount of Mai ya – a sprout which possesses the “springing-forth” nature of wood – so as not to insult the proud general – to let it still rise upward.
• The raw form is neutral, and is used mainly to reduce and guide out.
• The dry-fried form is warm, and is better at strengthening the spleen, improving the appetite, and inhibiting lactation.
• The powdered form is better for aiding in the digestion of grains.
Hsu: Slightly stimulates secretion of pepsin and gastric acid.
• Treats painful and swollen mammary glands and milk stagnation due to cessation of breast feeding.
MLT: For blocked lactation with distended breasts, take 25g raw sprouts and 25g fried, in decoction, each day.
BF: I have lots of experience using Mai Ya to stem lactation, both in China and the U.S. To achieve this effect, the med must be used in large doses (30-60g) and lightly stir-fried till aromatic. I have found this med to be very dependable for this effect, and there is quite a lot of published research on this med’s effect on PRL. I have used Mai Ya for women who had lost their babies during birthing, for women with galactorrhea due to hyperprolactinemia, and for women with galactorrhea-amenorrhea syndrome, and it has always worked.

Dose: 12-30g (6-15g directly as powder)

Shan Zha – Crataegus fruit – Hawthorn (C. pinnatifida or C. cuneata)

Nature: sour, sweet, slightly warm

Enters: Spleen, Stomach, Liver

Actions: Promotes blood circulation and dispels blood stasis and clumps; promotes digestion, eliminates food retention, digests fat. The partially charred form stops diarrhea (and is superior for moving blood).

Indications:
• Food retention: distended epigastrium, abdominal pain, diarrhea. Particularly for over-consumption of meat or fatty foods.
• Blood stasis: abdominal pain (including post-partum), clumps, testicular pain and hernial disorders.
• Chronic diarrhea/dysentery: use the partially-charred form.
• Breast lumps: use the seeds.
• Hypertension; coronary artery disease; elevated serum cholesterol.
• Oddly, this herb has been shown to promote hair growth in this study.
• This herb’s combination of sweet and sour flavors give it the potential to nourish Yin.
• The herb is used commonly used raw for dispelling blood stasis and is dry-fried for food stagnation.
Li: Softens hardness: clots, etc.
Jin: Add to phlegm-resolving formulas to treat phlegm due to food sensitivity.
• For acne: pimples are deposits of oil (fat) and this herb helps digest fat (see Jin’s acne formula.
• For weight loss: digests fat.
MLT: Reduces hypertension, cholesterol, blood lipids; also for murmurs, enlarged heart.
Yoga: V-, P+; K+ (in excess)
• Not for Pitta-type (hot) heart conditions.
• Especially good for Vata heart conditions like nervous palpitations, or the heart problems of old age (the age of Vata) like cholesterol and arteriosclerosis.
Hsu: Increases secretion of digestive enzymes; antibacterial, vasodilator.

Dose: 9-15g (to 30g)

 
Western Hawthorne, C. oxycantha and many other species (in Western herbalism, the leaves and flowers are also often used):
K&R: Cardiac sedative, hypotensive, sympatholytic, febrifuge, diuretic and astringent, coronary dilator, chronotrope negative (strong), bathmotrope negative, antispasmodic.
• Fire and wood excess:
Fire: slows and reinforces the heart’s contractions, treats tachycardia, extrasystoles, arrhythmia, promotes vasodilation of the coronaries and treats sequela of infarctus, increases oxygen supply to the heart, stimulates venous walls (varices, varicose ulcer), diminishes arterial tension, treats arterial hypertension, can reverse arteriosclerosis; diuretic.
• Diminishes diarrhea from full heat in the small intestine, inhibits the sympathetic tonus.
• Precordial pain or oppression, dyspnea, rapid and weak heart contractions, cardiac hypertrophy, endocarditis.
• Also for such Fire yang symptoms as: vertigo, dizziness, anguish, insomnia, night terrors, enuresis, hot flashes of menopause.
Wood: disperses liver and gallbladder channels, calms sympathetic nervous system, calms sympathotonic spasms, CNS sedative.
• The flowers and berries are astringent – use in decoction for a sore throat.
• East Asian uses: for blood stasis, menstrual pain, postpartum lower abdominal pain, intestinal bleeding, lower abdominal distention.
• Increases stomach acidity to help digest meats and fats.
• Treats bacterial dysentery and chronic enteritis.
• Chinese research has shown that its flavones can alleviate myocardial ischemia. Its flavones also can reinforce the crosslinking of collagen that forms connective tissue, and can prevent the release of pro-inflammatory substances such as prostaglandins, leukotrienes and histamine, and thus prevent tissue destruction in inflammatory diseases of the soft tissues.
• Potentiates the action of barbiturates.
• Topical: for angina.
• Not for acute cardiac insufficiency (use Lily of the Valley [Convallaria] or Foxglove [Digitalis]) – Hawthorn should be taken over time to improve the functional tone of the myocardium and prevent arteriosclerosis.
• Contraindicated for stomach ulcers with hyperacidity.
BII: Beneficial in: atherosclerosis, cardiac arrhythmia, CHF, hypertention, peripheral vascular disease, vascular fragility.
• Reduces angina attacks, lowers blood pressure and serum cholesterol.
IBIS: (berries, flowers, leaves)
• Qualities: sweet, slightly bitter, cool, dry, astringent.
• Affinities: heart, arteries, blood.
• Actions: cardiotonic, myocardial trophorestorative; coronorary and peripheral vasodilator, anti-arrhythmic, antioxidant, hypocholesterolemic, hypotensive, positive inotrope.
Dosage:
• Tincture (flowers & leaves) : 1 – 2 ml T.I.D.
• Tincture (berries) : 2 – 4 ml. T.I.D.
• (Preparations may vary, some are 50/50 Flower/Berries.)
• Dried herb : Infusion (flowers & leaves) Decoction (berries) Two teaspoons per cup (30gm/500ml) One cup T.I.D.
• Powdered dried herb : 500 – 1000 mg T.I.D.
• Standardized Extract : 100-250mg T.I.D. (Standardized to 1.8% vitexin or 10% total flavonoids as hyperoside)
• Therapy: coronary artery disease; angina pectoris; myocardial hypoxemia; Cardiac insufficiency (NYHA Stage I and II), arrhythmias; senile degeneration of the heart and atherosclerosis; post-infectious weakening of myocardium (Weiss pp. 164-65); paroxysmal tachycardia; Buerger’s disease, (British Herbal Pharmacopoeia), synergist to reduce dosage of cardiac glycoside herbs (or drugs).
• Specific indications: hypertension with myocardial weakness, angina pectoris (British Herbal Pharmacopoeia).
Pharmacology:
• Cardioactivity: It is established that Crataegus oligomeric procyanidins and flavonoids increase myocardial and coronary blood flow, that it is positively inotropic and and hypotensive, but the mechanism of action is unclear. Crataegus flavonoids inhibit cAMP Phosphodiesterase, and myocardial Na+/K+ ATP’ase. The same compounds exhibit high antioxidant free radical scavenging activity, and are hypolipidemic via an action on hepatic LDL receptors and increased bile secretion. Crataegus also inhibits TXA2 (Thromboxane) formation, while stimulating prostacycline. Crataegus prolongs rather than reduces the myocardial refractory period, unlike most positive inotropes, hence reducing risk of arryhthymia. Animal studies have confirmed the abilty of Crataegus to lower blood pressure, increase myocardial perfusion, minimize ischemic damage (reduces post infarct LDH by 50%).(Literature Review see American Herbal Pharmacopoeia).
Clinical trials:
• Several controlled studies have been performed with Crataegus extracts and NYHA stage I and II cardiac insufficiency patients. Crataegus increased exercise tolerance, decreased systolic BP and heart rate (Schmidt 1994), decreased severity of symptoms subjectively as well as HR, BP (Leuchtgens, 1993). In another group (n=1476) Crataegus decreased symptom severity by 66%, and was associated with systolic drop of 10mm and diastolic drop pf 5mm average blood pressure. (Loew, 1996)
Drug interactions:
• Crataegus will synergize with the cardiac glycoside containing plants such as Convallaria, Digitalis, Strophanthus, Urginea, Apocynum, Asclepias etc., as well as the hypotensive alkaloids of Veratrum and Rauwolfia. Western clinical herbalists use Crataegus as an adjuvant to lower the dose of these more toxic herbs required for effective action.
• Crataegus potentiates the activity of cardiac glycosides including digitoxin, digoxin etc. Patients using these medications should be monitored by a herbalist or physician since the dose of pharmaceutical drug will need to be reduced during intercurrent therapy.
Joseph Coletto (OCOM): Extract of the berry (e.g. Scientific Botanicals’ solid extract) is both tasty and excellent for oral lesions and irritation (administer repeatedly and hold in the mouth).

Notes on This Category – Drastic Purgatives / Cathartics

These herbs powerfully eliminate pathological factors (chiefly harmful fluid) by drastically promoting bowel movement.
The effect of these herbs is generally milder when they are roasted or dry fried.
Use with great caution, especially with weak patients. The results can be quite bad.
Contraindicated in pregnancy.

Commonly combined with:
A. Herbs that clear heat and nourish Yin when Yin is damaged by excess heat.
B. Blood tonics when there is blood deficiency.
C. Herbs that promote Qi circulation.
D. Herbs that release the exterior, when there is an EPI associated.
E. Herbs that support the Zhen Qi when the patient has a weak constitution.

Ba Dou – Croton seed – “Clinging Bean”

Nature: acrid, hot, toxic

Enters: Stomach, Lung, Large Intestine

Actions: Unblocks cold accumulation and vigorously purges the bowels; drives out water and reduces edema; dispels clogged phlegm, benefits the throat; promotes healing of abscesses and ulcers.

Indications:
• Severe cold accumulation in the interior: constipation, abdominal fullness, distention, pain.
• Phlegm clogging the throat: difficult breathing, wheezing, severe fullness and distention in the chest and diaphragm.
• Phlegm misting the sensory orifices.
• Ascites.
• Topical: for abscesses that have suppurated but not yet ulcerated, to accelerate the ulcerating process. Also for severe ulcers such as phagedena.
• Bowel obstruction: The prepared herb (see below) was used in 50 cases of intestinal obstruction. The adult dosage was 150-300mg; a lower dosage was used for children. When necessary, the dosage was repeated every 3-4 hours. 40 cases were cured. When there is severe obstruction or no response to this treatment within 48 hours, immediate surgery is required.
• This herb is extremely harsh and should always be used with caution. It is said to be able to “chop through the gate and open the door.”
• When taking this herb, one should avoid drinking hot liquids, as this may severely aggravate its laxative effect.
• If the herb causes unremitting diarrhea, one should take cold rice congee or a tea made from Huang lian and Huang bai.
• The herb is mainly used in its de-fatted form, Ba dou shuang.
• The oil: Oral administration of ½ to 1 drop of the oil causes a burning sensation in the mouth, gastric mucosa, and vomiting, then multiple episodes of watery diarrhea within 30-40 minutes, together with severe abdominal pain and tenesmus, and inflammation of the oral mucosa and GI tract. External application of the oil stimulates the skin and causes redness which may progress to blisters.

Dose: 0.1-0.3g in pills

Da Ji – Euphorbia pekinesis or Knoxia valerianoides – Peking spurge root – “Big Lance from the Capital”

Nature: bitter, acrid, cold, toxic

Enters: Lung, Kidney, Large Intestine

Actions: Strongly eliminates harmful body fluid by purging the bowels; relieves swelling, dissipates nodules.

Indications:
• Retention of harmful fluid: relatively moderate accumulation of fluid in the chest and flanks with such symptoms as labored breathing, dull pain in the lateral aspect of the chest, expectoration of thick sputum, a thick, greasy tongue coat; ascites, hydrothorax, edema.
• Phlegm and fire: lumps.
• Heat and toxicity: carbuncles and boils, red, swollen, painful, toxic, sores. Also used topically for sores and scrofula.
• Acute or chronic nephritis.
• Ascites due to schistosomiasis.
• Milder than Gan Sui.
• Cooking it with honey and Da zao reduces its harsh properties.
• Frying it in vinegar reduces its toxicity.
• Traditionally forbidden in combination with Gan cao. Recent animal studies have shown that a mixture of the two herbs has a much lower LD50 (i.e much higher toxicity) than Da ji alone.
MLT: Very similar to Gan sui. The two are often combined.

Dose: 1.5-3g (1g in powders)

Gan Sui – Euphorbia kansui root – “Sweet Process”

Nature: sweet, bitter, cold, toxic

Enters: Lung, Kidney, Large Intestine

Actions: Violently purges the bowels to strongly eliminate harmful body fluid; clears heat; reduces swelling.

Indications:
• Retention of harmful body fluid: severe accumulation of fluid in the chest and abdomen – ascites, hydrothorax; also for generalized edema, facial edema, abdominal distention. May be combined with Zhu ling to simultaneously promote urination.
• Internal wind and phlegm: epilepsy (uncommon use).
• Topical: for swollen, painful, nodular skin lesions due to damp-heat. This herb is most appropriately used during early stages of this disorder. Herbs that clear heat and eliminate toxicity should be given orally simultaneously.
• Within 30 minutes following administration, borborygmus and cramps will begin.
• The use of this herb is generally limited to robust patients with severe patterns of excess.
• May be given in alternation with Ren shen to avoid causing depletion.
• Frying in vinegar reduces its purgative function.
• Roasting it reduces its tendency to cause vomiting.
• Rarely used in decoctions. The active ingredients may not be water soluble.
• Traditionally forbidden in combination with Gan cao. Animal studies have not produced any conclusive data on this combination.
MLT: The juice can be used topically as a counterirritant to clear warts and other skin nodules.

Dose: 0.3-1g taken directly as power or in pill form

Qian Niu Zi – Morning Glory seed – Pharbitis (Ipomoea) – “Cowherd Seeds”

Nature: acrid, bitter, cold, toxic

Enters: Lung, Kidney, Large Intestine, Small Intestine

Actions: Drives out harmful fluid by promoting bowel movement and urination; dispels accumulation; expels phlegm and fluids; expels intestinal parasites, reduces food stagnation.

Indications:
• Heat accumulation in the stomach or intestines: severe constipation, abdominal distention, urinary difficulty, leg edema.
• Damp-heat accumulation in the stomach and intestines: constipation. (Lower dosage for this indication than the previous indications.)
• Fluid congestion obstructing the Lungs: cough, wheezing, fullness in the chest and abdomen.
• Roundworm or tapeworm infestation.
• Food stagnation.
• Dry-fry the herb for a milder effect.
• Contains d-lysergic acid amide, similar hallucinogenic effect to LSD in large doses.
MLT: Mildest herb in this category.

Dose: 4.5-9g (or 1.5-3g alone as powder)

Shang Lu – Poke root – Phytolacca – “Commerce Continent”

Nature: bitter, cold, toxic

Enters: Lung, Kidney, Large Intestine, Bladder, Spleen

Actions: Eliminates harmful fluid by promoting bowel movement and urination; relieves swelling, reduces sores and carbuncles.

Indications:
• Retention of harmful body fluid: edema, scanty urination, urinary difficulty, constipation.
• Heat and toxicity: carbuncles, sores. Also used topically.
• For skin lesions, it is ground up and applied as a paste with petroleum jelly, honey, or egg white.
• When used internally, it is generally stir-fried with vinegar, which reduces its toxicity.
• The root must be dried, aged more than 3 months, and cooked long to neutralize its toxic elements.
• The traditional antidote for poisoning from the herb (particularly from the berries) is fresh Gan cao and Lu dou (Mung bean).
JC: Powerful alterative, relaxant, cathartic, emetic, resolvent, deobstruent, detergent, anti-syphilitic, antiscorbutic, nutritive.
• Cancer, skin problems, hardened liver, scanty flow of bile, hard, swollen, or enlarged glands (especially the thyroid, spleen, lymph, breast), abnormal growths, bony enlargements from direct injury, rheumatism, dyspepsia, inflamed kidneys.
• Slow but persistently powerful action.
MW: For the stagnant person: lazy, flabby, tired, flops down after work, apathetic (especially teenagers), lack of personal delicacy, disregard of surrounding objects, indifferent to life, “For the person who eats, sleeps, and shits in the same place.” (A few drops of the tincture)
• Has definitely cured cancer. As a cancer preventative, boil it twice.
• For stagnant Qi, blood, and fluid.
NAH: Powerfully stimulates the lymphatic system: tonsilitis, swollen glands, mastitis (poultice).
IBIS: (fresh root, berries)
• Affinities: skin; glandular structures of the buccal cavity, throat, and sexual system; mammary glands; fibrous and serous tissues and mucous membranes of the digestive and urinary tracts; heart; spinal cord; bowels (Felter and Lloyd, p. 1473).
• Alterative, antirheumatic, anticatarrhal, cathartic, emetic, fungicide, narcotic, parasiticide.
• [Western] dosage: tincture of fresh root: 0.2 – 1 mL. tincture of berries: 0.2 – 1 mL. dry powder: 60 – 300 mg.
• Appearance: tongue hurts upon protrusion (Wood).
• Pulse: dull stroke with tremulous or vibratile wave (Scudder, 1903, p. 154).
• Specific indications: pallid mucous tissues with ulceration; sore mouth with small blisters on tongue and mucous membranes of cheeks; sore lips; hard, painful, enlarged glands; mastitis; orchitis; parotitis; aphthae; soreness of mammary glands, with impaired respiration; faucial, tonsillar, or pharyngeal ulceration; pallid, sore throat, with cough or respiratory difficulty (Felter and Lloyd, p. 1475).
• Internal: acute inflammations of the throat; adenitis; acute inflammations of the breast; children’s glandular and skin disorders; sciatic rheumatism; syphilitic disorders with ulceration; long-standing ulcers in psoriasis, dermal abscesses, fissures, boils, and carbuncles (Ellingwood, p. 375); chronic rheumatism; chronic respiratory catarrh; tonsillitis; laryngitis; mastitis (British Herbal Pharmacopoeia p. 157).
• External: as ointment in scabies, tinea, sycosis, acne; as poultice in abscess, mastitis (British Herbal Pharmacopoeia p. 157).
• Contraindicated in pregnancy.
• Laboratory test results: agglutination of red and white blood cells is promoted by pokeweed mitogen (Tedeschi, Eckart and Tedeschi, p. 1524); pokeweed mitogen has been found to stimulate both B and T lymphocytes (Kinghorn, p. 84-90; Von Oettingen, p. 500)

Dose: 3-9g

Notes on This Category

• Da huang, Lu hui, and Fan xie ye all contain anthraquinone glycosides which make them stimulant laxatives (as well as having some antibiotic effect) – increasing peristalsis. (The common Western herbal purgatives Cascara sagrada and Frangula are also stimulants containing anthraquinones.)
• Other common laxatives include citrus seed extracts and castor oil (the latter is a strong stimulant). Psyllium seed husk (a Plantago species), flax seed meal, and Pang da hai, when eaten, are high-fiber bulk-forming laxatives, which retain water and stimulate peristalsis by forming a mass in the intestines.
• All but the fiber (bulk-forming) laxatives are generally contraindicated in pregnancy.
• The herbs in this category are commonly combined with:
A. Herbs to clear heat and toxicity, promote Qi and blood circulation.
B. Herbs to warm the interior, when there is constipation due to Yang deficiency (e.g. Da huang + Fu zi).
C. Herbs that release the exterior, when there is an EPI associated.
D. Herbs that support Zhen Qi, when the patient has a weak constitution.

Chief Applications:
1. Dry and hard stool due to excess heat or fire in the large intestine.
2. High fever, coma, delirium due to blockage of the heart by excess heat.
3. Headache, red and painful eyes, toothache, hemoptysis, hematemesis due to flare up of fire from the liver, Lungs, stomach, or large intestine.
4. Tong Yin Tong Yang: Purgation when there is leakage (incontinence) due to blockage.

Da Huang – Rhubarb root and rhizome – Rheum – “Big Yellow”

Nature: bitter, cold

Enters: Stomach, Large Intestine, Liver, Heart, Spleen

Actions: Clears heat, reduces fire; eliminates toxicity; promotes blood circulation, dispels blood stasis; drains accumulation and stagnation; drains damp-heat; drains heat from the blood, clears heat obstructing the blood level.

Indications:
• Any accumulation or stagnation of heat or damp-heat in the large intestine, including Yangming stage invasion: high fever, profuse sweating, thirst, constipation, abdominal distention and pain, delirium, yellow tongue coat, full pulse.
• Stomach fire: hematemesis, epistaxis.
• Blood stasis: amenorrhea, lochioschesis, masses, trauma, hemorrhage, fixed pain, stasis due to intestinal abscess.
• Damp-heat: jaundice, painful urination, acute hot dysentery.
• Heat and toxicity: carbuncles, boils, furuncles, burns. Use internally and/or topically.
• Blood in the stool due to bleeding hemorrhoids or heat accumulation in the intestines.
• Excess heat obstructing the blood level: fever, hot, swollen, painful eyes, or fire toxin sores.
• Antineoplastic, antifungal, and antibacterial effects.
• May lower cholesterol.
• Also for schistosomiasis.
• Topical: for dermatitis, stomatitis, oral ulcers/canker sores.
• As a paste with vinegar on K-1 for abdominal distention. Change every 2 hours.
• Local application of a decoction has been shown to be effective in the treatment of stomatitis, oral ulcers, and folliculitis, especially those caused by Staphylococcus aureus.
• Ecthyma: a powder made of Da huang and Gan cao, used with a multilayered soybean plaster, was applied in 12 cases of ecthyma of up to 13 years duration. All cases healed within 1-4 weeks.
• A 1g dose has a mild effect to stimulate the appetite.
Da huang’s purgative effect takes 6-8 hours.
Da huang has astringent tannin which has a constipating effect that outweighs the purgative effect when taken in small doses (<0.3g).
• For strong purgation, cook only 5 minutes. The longer the cook time, the milder the purgative effect.
• The wine or vinegar treated form has a stronger effect of promoting blood circulation, and is a milder purgative.
• To stop bleeding, use the charred form.
• The alcohol-prepared form can direct to the face.
• When using Da huang, the sweat and urine may be notably yellow.
• Contraindicated for nursing mothers because components are excreted in breast milk.
• One of four herbs in Essiac tea, a cancer formula.
• Anti-inflammatory: a COX inhibitor
Li: “Dissolves fat” – for obesity, high cholesterol, etc. (including with Dan shen, Shan zha, San Qi).
K&R: Metal and wood excess.
• Metal: constipation, dyspepsia, dysentery.
Wood: biliary dyskinesia, gallstones, high cholesterol, blood stasis.
• Anti-inflammatory.
• Has bacteriacidal action against Bacerioides fragilis, which has been found in large quantities in the gallbladders of patients with hepatic or gallbladder disease.
BII: Reduces bleeding of duodenal and gastric ulcers.
Yoga: Amla-vetasa: P, K-; V+
• Purges Pitta, Ama, and stagnation.
DY: To moderate Da huang’s purgative effect, combine it with Gan cao.
• Can be used for any type of constipation, when combined with other herbs specific for the pattern.
• Up to 3g Da huang is lightly purgative and stimulates digestion. Over 3g, the higher the dose, the purgative its effect is. There is a wide variability in the degree of sensitivity of patients to the purgative effects of Da huang. Profuse diarrhea can occur with only 3g in one patient, while constipation can resist a 12g dose in another patient.
• Wine mix-fried Da huang is very slightly purgative. Carbonized Da huang is not purgative.
• With Fu zi to warm the interior, precipitate accumulation of cold, and evacuate the stools. For constipation, abdominal pain, fear of cold, and cold limbs due to accumulation of internal full cold. (Da Huang Fu Zi Tang).
When this pair is combined with Xi xin, it has shown an interesting action in the treatment of cold-damp Bi or impediment with Yang deficiency and blood stasis (use wine mix-fried Da huang for this) as well as for Bi with an accumulation of heat in the stomach and intestines with persistent constipation.
• It is noteworthy to mention that some practitioners believe that small doses (1-3g) of Da huang can have supplementing effects and that this medicinal can be integrated into any formula that supplements the middle burner. However, this is probably an indirect effect. As it is said, the bowels function when they are freely flowing. The spleen cannot be fortified and healthy if the stomach and intestines are not free flowing. In addition, when the spleen becomes weak and, therefore, loses its control over transportation and transformation, the stomach typically becomes hot due to accumulation and depression. Therefore, a small amount of Da huang can address this accumulation and heat even if the main symptoms are those of spleen deficiency and there is no marked constipation.
• With Mang xiao for mutual reinforcement, to effectively precipitate full heat and internal accumulation, and free the flow of stools. (Dose of each: up to 15g) For indications such as:
– 1. Constipation with dry, hard stools and abdominal pain which worsens with pressure due to heat accumulation in the Yangming bowels. (Da Cheng Qi Tang)
– 2. Constipation with dry, hard stools, high fever, delirium and mental confusion, and dry, yellow tongue fur due to full heat in the Yangming bowels. (Da Cheng Qi Tang)
– 3. Chronic or severe constipation due to heat.
MLT: For burns (not open sores) soak Da huang in vinegar for 1-3 days and apply locally.
• Use the charred form for diarrhea and to stop bleeding.
PFGC: Enters the blood layer, cracks all forms of stagnant blood. Since its Qi is fragrant, it can also enter the Qi layer – therefore, in small doses, Da huang can regulate Qi and treat Qi stagnation pain.
• Purges all kinds of masses and accumulations.
• Can treat mania by opening the epigastric region and resolving phlegm-heat. Use up to 60g when the pulse is clearly excess.
• Its fragrant orifice-opening effect can disinhibit urination.
• Can also clear heat in the upper Jiao – for all pain in the eyes and oral cavity.
• Descends stomach heat and “entices stomach Qi to move downwards” – excellent for hematemesis.
• Can “drain the old and generate the new.”
Hsu: Stimulates bile and pancreatic secretions; broad antibacterial; anti-carcinogenic effect.
JC: (“Turkey Rhubarb”) Cathartic (aperient to brisk purgative, depending on dosage), hepatic, cholagogue, astringent, tonic, stomachic, antibilious, sialogogue, vulnerary, anthelmintic, peristaltic.
• Given in small doses, it is a valuable stomach tonic, increasing saliva and gastric juices, improving the appetite, promoting the action of the liver and the flow of bile (without astringing the intestines), and facilitating absorption throughout the system.
• Increases circulation in the glands by the GI tract and increases peristalsis by stimulating the muscular layer of the bowel.
• In larger doses (2-3g), it produces copious yellow, pultaceous stools in 6-8 hours, with considerable hepatic stimulation and some griping (although the larger doses may produce severe griping, the herb will never inflame the digestive mucous membrane).
• Highly esteemed as a laxative tonic for children and infants because of the milk-like quality of its action. It acts chiefly on the duodenum, and generally does not clog or produce an after-constipation. The tonic and astringent action following evacuation makes it a valuable remedy for diarrhea due to irritating matter in the bowel – it removes the irritating substance, its astringent properties check the diarrhea, and then it tones and corrects the accompanying atonic indigestion.
• Particularly useful for hemorrhoids with constipation, atonic dyspepsia, infantile digestive and intestinal disorders, and both constipation and diarrhea.

Dose: 3-12g

Fan Xie Ye – Senna leaf – Cassia angustifolia or C. acutifolia – “Purgative Leaf of the Foreigners”

Nature: sweet, bitter, cold

Enters: Large Intestine

Actions: Purges accumulation and stagnation.

Indications:
• Excess heat in the large intestine: constipation.
• Do not cook too long (over 10 minutes) or at too high a temperature – just add to water at 95°-100° C and let it steep. Water temperatures under 75° C will not be hot enough to extract the purgative constituents of this herb. Cooking over 1 hour will completely eliminate any purgative properties.
• Doses over 10g may cause nausea, abdominal cramps, and vomiting (can be combined with Huo xiang to prevent these side effects).
Fan xie ye’s purgative effect takes 2-6 hours.
• Sources conflict on Fan xie ye’s strength and nature:
Liu: Milder purgative than Da huang.
Li: Stronger purgative than Da huang.
BII: Probably the best-tolerated laxative.
MLT: Can cause griping – combine with a warming herb to counteract this side effect (e.g. Sheng jiang, Chen pi).
K&R: Metal yang, water yang.
• Inhibits resorption of water from the colon.
• Contraindicated with intestinal inflammation, pelvic congestion, or pregnancy.
JC: Cathartic (pods: laxative; leaflets: simple purgative), slight stimulant, antibilious, anti-periodic, tonic.
• A somewhat prompt cathartic that acts on nearly the entire intestinal tract, especially the colon. Suitable for chronic constipation. Acts locally on the intestine wall, increasing peristalsis and secretions, to produce copious yellow stools. Does not constipate afterwards.
• The leaves cause griping and flatulence (the pods do not), and the odor is nauseous to many persons. The griping and nausea may be alleviated by adding some corrective herb, such as: cloves, ginger, cinnamon, coriander, fennel, manna, etc. Often given with licorice.
• Two main varieties, Alexandrian or Nubian senna (Cassia acutifolia, C. senna, C. lenitive, C. officinalis, C. aethiopica) and East Indian or Tinnevelly senna, are used. The former is preferred by most herbalists since it is milder, but equally certain in its action.
• Should not be used when there is an inflamed condition of the GI tract.
• Shortly after administration (2-30 minutes) it may dye the urine reddish.
IBIS: Drug interactions:
• Sennosides aggravate nephropathy from analgesics associated with dehydration (DeSmet).
• Decrease in absorption of oral drugs due to decrease in bowel transit time (DeSmet).
• Aggravates loss of potassium associated with use of diuretics (DeSmet).
• Overuse or misuse can cause potassium loss leading to increased toxicity of cardiac glycosides (Wichtl, DeSmet) such as those in Adonis, Convallaria, Urginea, (Brinker, DeSmet) Helleborus, Strophanthus, and Digitalis (Brinker).

Dose: 1.5-3g for mild purgation. 5-10g for strong purgation.

Lu Hui – Aloe (dried concentrate) – A. vera or A. ferox

Nature: bitter, cold

Enters: Liver, Large Intestine, Stomach

Actions: Clears liver heat; kills parasites (especially roundworms) and strengthens the stomach; purges accumulation and stagnation; drains fire.

Indications:
• Heat accumulation (liver and/or large intestine): constipation, dizziness, headache, tinnitus, irritability, fever. Also used for chronic constipation.
• Roundworms. Also for ringworm.
• Childhood nutritional impairment, especially when due to roundworms: abdominal pain, sallow face, thin muscles.
• Stronger than Da huang, but can be mild when dosed appropriately.
• Very bitter. Often encapsulated.
• As effective in enema form as when taken orally.
Liu: Less likely to cause griping than Da huang.
Hsu: Low doses are a cholagogue, stimulate intestinal peristalsis.
• High doses induce abdominal pain and congestion of the pelvic cavity.
• Anti-carcinogenic effect.
• Aloe ulcin inhibits histamine synthesis.
IBIS: Note: The leaf gel, commonly consumed as a cleansing juice preparation, is a different product. (McGuffin, p.7).
• Affinities: intestines, skin.
• Actions: laxative on lower gastrointestinal (slow acting 10-15 hours), can also be a purgative; cathartic; bitter tonic, stomachic, hepatic; vermifuge/ anthelmintic; emmenagogue; vulnerary, demulcent, and emollient.
• Dosage: tincture: 1 – 4 mL. resin [Lu hui]: 100 – 300 mg.
• Therapy: atonic constipation; burns; to increase menstrual flow; insect bites; asthma.
• Toxicity varies between different species and varieties of Aloe; barbaloin can be very griping (especially in dried form) and cause severe intestinal irritation; Aloe vera [Lu hui], which has very little, if any, barbaloin, is usually considered non-toxic.
• Contraindicated in pregnancy and cases of menorrhagia or metrorrhagia; also in patients with gastrointestinal inflammation, irritable plethoric conditions and hemorrhoids; not to be used by patients with chronic constipation (Felter and Lloyd, pp. 151-152; Morton, pp. 47-50; U.S. Dispensatory, pp. 46-50).
• Produces catharsis in nursing child (Morton, pp. 47-50).
• May cause or potentiate kidney irritation (Brooks).
• Contraindicated in children younger than 12 due to depletion of electrolytes and water (De Smet).
• Extended use of more than 8-10 days may cause loss of peristalsis from intestinal smooth muscle and mesenteric plexi damage (De Smet).
• Drug interactions: Aloe can cause potassium loss which may lead to increased toxicity of cardiac glycosides such as those in Adonis, Convallaria, Urginea, Helleborus, Strophanthus, and Digitalis (De Smet; Wichtl). Aloe can reduce the absorption of oral drugs and increases potassium loss caused by diuretics (De Smet).

Dose: 0.3-3g (usually taken directly as powder or in capsules)
Aloe in various forms (fresh gel, extract, powder):
BII: Cancer: contains a potent immunostimulant polysaccharide – acemannan – especially effective for leukemia, but also should be considered for: HIV, bronchial asthma, diabetes mellitus, immunodepression.
• May have an anti-ulcerative effect on the GI tract.
Yoga: Kumari: A young girl/virgin, called so because it imparts the energy of youth and brings about the renewal of the female nature.
• Bitter, astringent, pungent, sweet/cooling/sweet.
• VPK= (gel). The powder, except in very low doses, will aggravate Vata.
• Alterative, bitter tonic, rejuvenative, emmenagogue, purgative, vulnerary.
• Regulates sugar and fat metabolism.
• Tonifies all Agnis. Reduces Pitta.
• Fever, constipation, obesity, inflammatory skin diseases, swollen glands, conjunctivitis, bursitis, jaundice, hepatitis, enlarged liver or spleen, herpes, venereal disease, amenorrhea, dysmenorrhea, menopause, vaginitis, tumors, intestinal worms.
• The powder is a strong purgative. Caution: take with a carminative (turmeric, rose, etc.).
DH: For a dry person/constitution. Doctrine of signatures: Aloe retains moisture, even in extremely dry environments.

Notes on This Category

• Also consider, as appropriate, these herbs from other categories which also moisten the intestines:

Bai Zi Ren [Calm Shen], Dang Gui [Nourish Blood], Dong Kui Zi [Drain Damp], Feng Mi  [Tonify Qi], Gua Lou Ren [Resolve Phlegm-Heat], He Shou Wu [Nourish Blood], Hei Zhi Ma [Nourish Yin], Hu Tao Ren [Tonify Yang], Jue Ming Zi [Subdue Lv/Exting Wind], Lu Hui [Purge to Eliminate Pathogens], Mai Men Dong [Nourish Yin], Mang Xiao [Purge to Eliminate Pathogens], Niu Bang Zi [Acrid, Cool], Qin Jiao [Dispel Wind-Damp], Rou Cong Rong [Tonify Yang], Sang Shen  [Nourish Yin], Su Zi [Stop Cough], Suo Yang [Tonify Yang], Tao Ren [Promote Blood Circulation], Xing Ren [Stop Cough], Zi Cao [Clear Heat/Cool Blood].
• In addition, consider herbs that generate body fluids, herbs that moisten the Lungs, herbs that nourish Yin and Blood, herbs that mobilize stagnant Qi and blood, and, when appropriate, herbs that purge accumulation.

Huo Ma Ren – Ma Zi Ren – Cannabis seed – “Fire Hemp Seeds”

Nature: sweet, neutral

Enters: Large Intestine, Stomach, Spleen

Actions: Slightly nourishes blood/Yin; moistens the large intestine to promote bowel movement; clears heat; promotes healing of sores.

Indications:
• Blood deficiency, Yin deficiency, or body fluid deficiency: constipation, especially in the elderly, postpartum, or after febrile disease.
• This herb must be ground before use.
• An auxiliary herb for sores and ulcerations. Taken orally or applied topically.
• Mildly lowers blood pressure.
• Doses over 60g may cause nausea, vomiting, restlessness, diarrhea.
• Sometimes the name Ma Zi Ren is used to refer to flax seed.

Dose: 9-30g (to 45g when used as the principal herb in a prescription)

Yu Li Ren – Bush Cherry pit – Prunus japonica or P. humulis – “Constrained Plum Pit”

Nature: acrid, bitter, neutral

Enters: Large Intestine, Small Intestine, Spleen

Actions: Moistens the large intestine to promote bowel movement; promotes urination to treat edema.

Indications:
• Dryness or Qi stagnation in the intestines: constipation.
• Edema with abdominal distention or leg qi with difficult urination and constipation.
• Stronger than Huo ma ren at moistening the intestines and promoting bowel movement.
• For stubborn insomnia after a frightening event, this herb is taken as a folk remedy: Decoct it in yellow wine for 10 minutes, then add the drained seeds to an appropriate prescription based on the diagnosis.
• Some patients may get slight cramps in the intestines from this herb.
• Crush before use.
MLT: Contains 60-75% oils which give it its lubricating properties.
Hsu: Emollient laxative, stronger purgative than cannabis; diuretic.
Dose: 3-9g

Notes on This Category

These herbs work predominantly by any of four major actions:
1. Descending Lung Qi.
2. Astringing Lung Qi.
3. Dispersing Lung Qi.
4. Moistening the Lungs.

As appropriate, consider combining with:

– herbs that resolve phlegm
– astringents
– herbs that warm the interior
– yin tonics
– Qi tonics
– yang tonics
– surface releasing herbs
– herbs that clear heat
– herbs that eliminate food retention, etc.

In my own practice, I have encountered some stubborn cases of cough that didn’t respond satisfactorily to any/all the herbs in this category (administered, of course, in an appropriate formula based on the zangfu pattern). Perhaps my formulas were flawed. However, over the years I have grown to trust three herbs more than any others for difficult coughs: Chuan bei mu, the Western herb Mullein (leaf and fower), and the needles of evergreens (Pine, Spruce, and Fir). The Western herb Lobelia (inflata sp.) is also a powerful, if also enigmatic, herb in the treatment of respiratory complaints. While it is an emetic in moderate doses, small doses can be used as an “activator” of the respiratory tract in combination with an appropriate formula.

Bai Bu – Stemona root – “Hundred Parts”

Nature: sweet, bitter, neutral

Enters: Lung

Actions: Moistens the Lungs, stops coughing; kills parasites.

Indications:
• Acute or chronic cough: Especially useful for deficiency cough, including Yin deficiency. A key herb for tuberculosis. Pertussis: over 85% effectiveness rate in one clinical series of over 100 patients. In other studies a preventative function was also noted.
• Topical: as a tincture or decoction for lice, pinworms, fleas, bedbugs.
• For pinworms, Bai bu can also be used as an enema, 30-60g per day for 3 days.
MLT: For lice, apply a 20% alcoholic solution or strong decoction. Also can be used as a flea wash for animals.
Hsu: Pesticide, antitussive, antitubercular, antibacterial, antifungal, antiviral.

Dose: 3-9g

Bai Guo – Ginkgo nut – “Silver Almond”

Nature: sweet, bitter, astringent, neutral, slightly toxic

Enters: Lung, Kidney

Actions: Astringes the Lungs to relieve wheezing; expels phlegm, softens stubborn phlegm; eliminates dampness; stops discharge; stabilizes the lower Jiao.

Indications:
• Difficult breathing, wheezing, coughing, with copious sputum.
• Kidney or spleen Qi deficiency or damp-heat: vaginal discharge, turbid urine.
• Lower Jiao instability: frequent urination, incontinence, spermatorrhea.
• Use raw for treating phlegm and clearing heat.
• Use prepared to stop wheezing and restrain urine.
• May aid in alcohol withdrawal by causing a distaste for alcohol.
• Because of its greater toxicity, when the raw herb is used, its dosage is usually reduced.
• Usually the husk is removed and the seed is crushed before use.
• Cautiously used for coughs with thick and sticky sputum, and in cases of excess.
• Symptoms of overdose include vomiting, headache, fever, tremors, irritability, dyspnea. The antidote is 60g of boiled Gan cao or 30g of boiled ginkgo shells. This reaction may be avoided by including the hard shells and thin linings of the seeds when using this herb.
• Bensky/Gamble classifies this herb as an astringent.
Hsu: Antibacterial, antiviral effects.

Dose: 4.5-9g

Kuan Dong Hua – Coltsfoot flower – Tussilago – “Welcome Winter Flower”

Nature: acrid, warm

Enters: Lung

Actions: Descends (and disperses) Lung Qi; moistens the Lungs; resolves phlegm; stops coughing.

Indications:
• A key herb for many types of cough. Can be used alone for damp-phlegm or cold-phlegm. For phlegm-heat, combine with cool herbs.
• Fry in honey to enhance its ability to moisten the Lungs.
• Often combined with Zi wan since Zi wan is superior for resolving phlegm while Kuan dong hua is superior for stopping coughs.
K&R: Emollient, expectorant, antitussive, vagolytic, slightly diaphoretic and tonic.
• Metal yin: cough, acute bronchitis, laryngitis, tracheitis, lymphadenitis, postinfectious fatigue, emphysema, silicosis.
• Contains pyrrolizidine alkaloids – may damage the liver with excessive use.
RW: The combination of its bitter and mucilaginous qualities gives it expectorant/demulcent plus tonic properties.
• The choice remedy in chronic respiratory problems, especially chronic emphysema and silicosis: have a cup of the tea immediately upon waking, while still in bed.
• Reports of carcinogenicity may be disregarded if the herb used properly.
MLT: Pertussis.
PCBDP: Recent research: anti-inflammatory, immunostimulant, demulcent, antispasmodic.
MW: Good for deteriorating respiratory conditions, “incurables” – e.g. emphysema.
• Also for sore feet with respiratory conditions.
• Alcohol extracts its alkaloids – therefore, always take it as a tea rather than as a tincture.

Dose: 1.5-9g

Ma Dou Ling – Aristolochia fruit – Birthwort – “Bell of a Horse’s Hat”

Nature: bitter, slightly acrid, cold

Enters: Lung, Large Intestine

Actions: Resolves phlegm; clears Lung heat; stops coughing, relieves wheezing.

Indications:
• Lung heat: cough with difficult breathing.
• Lung deficiency: prolonged cough.
• Bleeding hemorrhoids.
• Hypertension with lightheadedness and flushing: lowers blood pressure an average of 15 mm Hg diastolic.
• Very bitter. May make some patients vomit. Gua lou is often substituted.
• Honey-frying this herb makes it less cold and bitter, and reduces the side effects of nausea and vomiting.
• Contains aristolochic acid [only slightly soluble in water – Merck Index], which has been associated with renal damage when misused. This herb is likely obsolete in the United States due to legal restrictions on its import and use.

Hsu: Strong expectorant (stronger than ammonium chloride).

Dose: 3-9g

Mu Hu Die – Oroxylum seed – “Wood Butterfly”

Nature: sweet, bland, cool

Enters: Liver, Lung

Actions: Moistens the Lungs, clears the voice, stops coughing; comforts the liver, regulates Qi; topically promotes healing of sores.

Indications:
• Hoarseness, cough, sore throat.
• Qi constraint: flank and epigastric pain.
• Topical: ulcerated, suppurative sores.
Hsu: Anti-inflammatory, decreases capillary permeability.
Li: Often uses to free constrained liver Qi.
SD: Oroxylum refers to the seeds from the tree Oroxylum indicum, commonly called the Tree of Damocles. The tree has been named after an incident depicted in an ancient story by Cicero, in which there is a sword hanging over the head of Damocles, from which we get the well-known reference to the “sword of Damocles.” This tree has long, fruit pods that hang down from the branches, looking like dangling swords. Within these pods are the seeds that come to be used in Chinese herbal medicine; when the pod bursts open the seeds flutter to the ground, often traveling some distance, looking like butterflies. Thus, the seeds, with their white, paper-thin “wings” are known to the Chinese as muhudie, or the tree butterfly (mu= tree; hudie = butterfly).
The traditional use of this herb is for moistening the lungs to control dry cough due to heat; restoring normal voice in cases of hoarseness or irritation; resolving liver qi stagnation and improving the flow of qi; and harmonizing the stomach. It is also used topically, to help treatment of persistent skin ulcers. Oroxylum is a relatively rarely used herb, and it is not found in many of the Materia Medica books available in English.
The seed contains oils and flavonoids (1, 2). One of the main flavonoids, chrysin, has been the subject of much study; among its potential applications is to alleviate anxiety (related to alleviating liver qi stagnation); chrysin is one of the main active components in the popular sedative plant passionflower (Passiflora coerulea). Oroxylum seeds also contains the flavonoid baicalein and its derivatives; this compound, usually obtained from Scutellaria baicalensis (named after this particular species, which also contains chrysin as one of its flavonoids), has been shown to have several useful applications for lung diseases. Chrysin, baicalein, and the other flavonoids in oroxylum have anti-inflammatory and anti-allergy effects, though the herb and its flavonoids may need to be used in high doses to get those responses.
Oroxylum root bark is the part used in Ayurvedic medicine, administered as an astringent, bitter tonic, stomachic, and anodyne. It is included in famous tonic formulations, such as Chyawanprash.

Dose: 1.5-9g

Pi Pa Ye – Loquat leaf – Eriobotrya

Nature: bitter, neutral

Enters: Lung, Stomach

Actions: Descends stomach and Lung Qi; harmonizes the stomach, clears stomach heat; resolves phlegm; stops coughing; clears Lung heat.

Indications:
• Wind-heat, dryness, or fire in Lung: cough with sticky sputum. Especially suitable for dry coughs.
• Stomach heat: vomiting, belching, hiccups, nausea.
Pi pa ye’s expectorant action is very mild.
• Common ingredient in acne formulas – benefits the skin by clearing the Lung.
• Hairs on the leaf may cause throat irritation, belching, or vomiting. The leaves are therefore usually scrubbed to remove the hair. These side effects can also be avoided by honey frying the herb, which additionally gives the it the ability to moisten the Lungs.
• Frying in ginger juice enhances its ability to stop nausea and vomiting.
Hsu: Antitussive, expectorant, antiviral.

Examine.com:

1. Sources and Composition

1.1. Sources

Eriobotrya japonica (of the family rosaceae) is a Food Product known as Loquat, Biwa, or Pipa (English, Japanese, and Chinese respectively) and is also sometimes called Japanese or Chinese Plum (despite not belong to the genera of fruits known as plums, the prunus fruits). The food product is a fruit weighing 20-80g with a thin and tough skin yet an internal pulp varying in color from white to deep orange to salmon pink.[1]

The term ‘Loquat’ refers to the genera (eriobotrya) rather than the species (eriobotrya japonica), and this particular species is called common or wild Loquat (with a variant, eriobotrya japonica var. zaozhong known as ‘Zaozhong 6’ Loquat) and is the most commonly sold Loquat;[2] others include Tibet Loquat (eriobotrya elliptica), Oak leaf (eriobotrya prinoides) and Daduhe Loquat (eriobotrya prinoides var. dadunensis), Taiwan (eriobotrya deflexa) and Hengchun Loquat (eriobotrya deflexa var. koshunensis), Bengel Loquat (eriobotrya bengalensis), Fragrant Loquat (eriobotrya fragrans), Guangxi Loquat (eriobotrya kwangsiensis), Obovata Loquat (eriobotrya obovata), and Big flower Loquat (eriobotrya cavaleriei).[2]

Eriobotrya japonica is one of various species in the genera (Eriobotrya) that refers to Loquat fruits, and it the most commonly sold species in this family for the purposes of being consumed

The leaves that this plant bears appear to be a Traditional Chinese Medicine by the name of pipaye and for the treatment of lung-related diseases including cough, asthma, and chronic bronchitis as well as for headache, lower back pain, and dysmenorrhea[3][4] as well as to quell the stomach and reduce vomiting during sickness.[5] The flowers also appear to have a similar history, being used for cough and sputum amongst other lung-related issues.[6]

This plant appears to have historical usage for the treatment of lung related disorders and some other possibly inflammation related disorders (headache and lower back pain)

1.2. Composition

The leaves of Loquat (Eriobotryae folium) contain:

  • Euscaphic acid,[12][13][14] 1?-hydroxyeucsaphic acid,[15] and a ferulic acid derivative known as 3-O-trans-feruloyleuscaphic acid[16][17]
  • Ursolic Acid (16mg/g dry weight in one study[18] but elsewhere at 1.969-5.675mg/g;[12] usually 50% of total triterpenoids[14]), 2?,19?-Dihydroxy-3-oxo-urs-12-en-28-oic acid, 2?,3?,19?-trihydroxyolean-12-en-28-oic acid (0.992-2.972mg/g[12]), and 2?-hydroxyursolic acid (4.6mg/g dry weight[18]),[13] and 2?,3?-dihydroxyursolic acid (0.615-1.190mg/g[12]). An ursolic acid lactone is also present in low levels[15]
  • Corosolic acid (1.887-5.396mg/g dry weight[12]) and 3-epicorosolic acid[15]
  • Oleanolic acid[13] at 1.7mg/g dry weight in one study[18] and 0.530-1.637mg/g elsewhere;[12] also ?-hydroxyoleanolic acid[14] and ?-oleanolic acid[15]
  • Maslinic acid[13] at 800µg/g dry weight in one study[18] and 0.869-1.890mg/g elsewhere[12]
  • Betulinic acid and methyl betulinate[15]
  • Arjunic acid[14] and methyl arjunolate[15] (named after Terminalia arjuna)
  • Pomolic acid[13]
  • Tormentic acid (20mg/g in the callus but not detectable in the leaves in one study[18] but at 0.579-1.858mg/g elsewhere[12]) as well as 3-O-p-coumaroyltormentic acid (cis and trans isomers)[3][18] at 2.9mg/g in the callus yet only 200µg/g in the leaves[18] and 23-O-coumaroyltormentic acid (both isomers)[19]
  • Hyptadienic acid[3][18] and Nerolidiol glycosides[20][21]
  • Cinchonain IIb (flavonolignan)[22] and Cinchonain Id 7-O-glucoside[22][23]
  • Glycosides of Vomifoliol (Megastigmane; aka. 3-oxo-?-ionol) including Eriojaposide A (6R,9R isomer with 9-O-?-xylopyranosyl-(1″?6′)-?-glucopyranoside[16][22]) and B (6R,9R isomer with 9-O-?-rhamnopyranosyl-(1″?6′)-?-glucopyranoside[16]) as well as a 3-oxo-?-ionyl-9-O-glucoside (6R,9R isomer),[22] (6S,9R)roseoside (glucoside),[22] 9-O-apiosyl?(1?6)?glucoside and an apiofuranosyl variant,[16][22] xylosyl?(1?6)?glucoside,[22] and Citroside A[16]
  • (-)-Epigallocatechin-3-O-gallate (EGCG)[22]
  • Quercetin as 3-Sambubioside and 3-rhamnoside[24]
  • Kaempferol as 3-rhamnoside[24] and the acetylated flavonoid kaempferol-3-O-?-L-(2?,4?-di-E-p-coumaroyl)-rhamnoside[25][26]
  • Naringenin (as 8-C-?-L-rhamnopyranosyl-(1?2)-?-D-glucopyranoside)[23]
  • Chlorogenic Acid and methyl chlorogenate,[24] a variant with higher antioxidative properties[27]
  • Procyanidin B2[22] and C1[22] as well as other oligomers[22][23]
  • Ferulic acid[20]
  • ?-sitosterol[16]

When comparing species of the eriobotrya genera against one another, the japonica species appears to have either comparable or lower flavanoid and phenolic content in their leaves;[2] being measured at 31.47-47.5mg/g phenolics as gallic acid equivalents (GAEs) and 109.3+/-4.8mg/g flavonoids as rutin equivalents (REs) based on dry weight of the leaves.[2][28] Relative to other plants in Traditional Chinese Medicine, eriobotrya japonica appears to have a high phenolic content behind only dioscorea bulbifera and tussilago farfara.[28]

The ethyl acetate extract has been known to concentrate the pentacyclic triterpenoids, where a metabolic extract (20.1% yield) can be fractioned into an ethyl acetate extract (24% yield; 5% total dry weight) results in higher levels of ursolic acid (9.7%), euscaphic acid (4.9%), corosolic acid (4.4%), 3-O-trans-coumaroyltormentic acid (4.0%), 1?-hydroxyeuscaphic acid (2.9%), oleanolic acid (2.7%), maslinic acid (1.7%), 2?,3?,23?-trihydroxyolean-12-en-28-oic acid (1.3%), 3-O-cis-coumaroyltormentic acid (0.8%), 3-epicorosolic acid, methyl ursolate, and methyl arjunolate (each 0.2%) and ursolic acid lactone, betulinic acid, methyl betulinate, and ?-oleanolic acid (each 0.1%).[15]

For the most part, the leaves contain either triterpenoids (of which ursolic acid is by far the largest in amount and has a bunch of hydroxylated and acetylated variants) and the vomifoliol glycosides; there are also the common catechins and the procyanidins that they form

The flower of loquat tends to contain:

  • Oleanolic acid (0.38-0.51mg/g dry weight[29]) and 2?,3?,23?-trihydroxyolean-12-en-28-acid[30]
  • Ursolic acid (2.15-2.68mg/g dry weight[29]) and 2?,3?,19?-trihydroxyurs-5,12-dien-28-acid[30]
  • Amygdalin (1.23-1.56mg/g dry weight[29])

The flowers have a total flavonoid content of 1.59+/-0.24mg/g and total phenolic content of 7.89+/-0.87mg/g dry weight;[6] they appear to be concentrated in methanolic and ethanolic extracts and less in ethyl acetate and acetone extracts, and antioxidant potential of the flowers generally correlates with the flavonoid and phenolic content.[6]

The flowers contain both triterpenoids and flavonoid components, with most (but not all) of the antioxidant potential probably coming from the flavonoids

The seeds of loquat tend to possess:

  • Proteins at 4.9% dry weight[31]
  • Lipids at 2.4% dry weight[31]
  • Sugars (carbohydrate) at 72.1% dry weight[31]
  • A mostly insoluble fiber content of 7% dry weight[31]
  • An ash content of 2.1% dry weight[31]
  • Amygdalin at 20mg/g dry weight[31]
  • Catechins such as (+)-catechin (2.16mg/g), epicatechin (0.68mg/g), epigallocatechin (0.12mg/g), and epicatechin gallate (0.09mg/g)[31]
  • Chlorogenic acid (0.04mg/g)[31]

Despite traditional usage of the seeds (particularly ethanolic extracts), there are not many unique constituatives in them relative to the leaf extracts; they do seem to be higher in carbohydrates than many seeds, however

1.3. Formulations and Variants

There appears to be an anti-acne compound formulation known as BC-AF which consists of eriobotrya japonica, saliva miltiorrhiza, and glycyrrhiza uralensis (Licorice).[32]

Some traditional chinese medicines have been paired together in the form of an anti-acne medication

It appears that loquat leaves can be fermented with camellia sinensis tea leaves (primary source of Green Tea Catechins) in a 1:9 ratio,[33] and when this occurs it develops synergism in inhibiting carbohydrate uptake;[34] the IC50 for inhibiting maltose uptake via inhibiting the maltase enzyme (65µg/mL) is three-fold higher than either plant alone, and this is thought to associated with the unique bioactives theasinensin A (IC50 142µM), theasinensin (225µM), strictinin (398µM) and 1,6-digalloylglucose (337µM), although it seems most of the inhibitory effects were attributed to currently not known molecules.[34] It does, however, appear to accelerate the production of Theaflavins gallates and thearubigins relative to fermenting camellia sinensis alone, without affecting the Caffeine content of the green tea.[35][36]

There also appears to be inhibitory effects on the sucrase enzyme (IC50 of 200µg/mL) which was mostly due to camellia sinensis but was still greater than it alone (IC50 350-430µg/mL) suggesting slight enhancement.[34] There also appears to be an inhibitory effect on lipid absorption (thought to be due to pancreatic lipase inhibition at around an IC50 value of 1.081mg/mL), and when given to rats at mg/kg prior to a soybean emulsion noted a significant reduction in lipid spikes in serum.[36]

This combination has been used successfully to reduce serum glucose spikes following oral ingestion of maltose (with 50mg/kg of the hot water extract of the combination) by 23.8%[37] and the suppression of insulin spikes following said meal was said to be 16-fold higher than the reference drug arcabose;[37] when given alongside the diet, the combination in rats appears effective in reducing obesity and high blood triglycerides.[36]

Fermenting one part loquat leaves alongside nine parts green tea leaves appears to synergistically increase how effective the green tea leaves are at inhibiting maltose and sucrose uptake from the intestines. In a sense, the fermentation process of green tea (to make it black tea) may be enhanced when 10% of the leaves are loquat

2. Longevity

2.1. Rationale

The 70% ethanolic extract of the seeds of eriobotrya japonica incubated in fibroblast at 0.5-2% of medium noted that the bradykinin-induced calcium efflux seen in senescent cells (which normally have attenuated calcium release in response to stimulators[38][39]) was restored to levels seen in young cells and increase the number of overall cells in culture that responded to bradykinin, although it failed to have a per se influence on young cells at the same concentration.[40]

Due to restoring a biomarker that is impaired with aging to levels seen in youthful control, the seed extract of eriobotrya japonica is thought to have antiaging properties

3. Neurology

3.1. Neuroprotection

In PC12 cells incubated with A?1-42 (neurotoxic protein fibril), a 5% ethanolic leaf extract preincubated for 24 hours is able to preserve cell viability in a concentration dependent manner in the range of 5-100?g/mL, reaching a protective effect similar to 100?M Vitamin C.[41]

The antioxidant effects cause some general neuroprotective effects; no in vivo evidence at this point in time and practical significance of this information is not known

3.2. Analgesia

An n-butanolic leaf extract (0.7% yield of dry leaves) at 250-500mg/kg oral ingestion appears to possess anti-nocioceptive properties in a battery of tests (tail immersion, hot plate, acetic acid writhing, and formalin) with a potency either comparable to or slightly lesser than the reference drugs of tramadol (intravenous injections of 10mg/kg) and indomethacin (oral);[42] the leaf extract appears to be antagonistic with opioid drugs in reducing pain acutely (30 minutes after oral intake), with no interaction at later times (60-120 minutes).[42]

While components of the leaf may have respectable analgesic effects, this is limited to a high oral dose of a very limited concentration and likely does not apply to oral supplementation of this plant (seeds or leaves)

3.3. Memory and Learning

Eriobotrya japonica leaf extract (5% ethanolic) fed to mice at the dose of 100-300mg/kg for three weeks prior to injections of A?1-42 (and then administered for another week) is able to attenuate the learning deficits seen by attenuating the 65% reduction in step-through latency (A?1-42 control) to 21% and 14% (100mg/kg and 300mg/kg, respectively).[41]

Alongside the neuroprotective effects are anti-amnesiac effects in a model of brain damange from protein fibrils (related to Alzheimer’s disease); the dose is not an impractically high dose, suggesting that it may be relevant

4. Cardiovascular Health

4.1. Absorption

Eriobotrya japonica leaves appear to inhibit pancreatic lipase with an IC50 value of 4.5mg/mL, which is weaker than camellia sinensis (IC50 of 2.245mg/mL) although it appears to be synergistic when fermented alongside camellia sinensis at a 1:9 ratio (IC50 of 1.081mg/mL);[36] this synergism also manifested during an oral triglyceride load, with the leaves of loquat by themselves at 200mg/kg inhibiting the subsequent AUC in serum by a minimal 2.2% (camellia sinensis by itself 35%) and the mixture by 62%.[36]

Appears to be able to inhibit fat absorption by an incredibly small amount, and practically speaking this is probably too small to exert any appreciable effect in the body

4.2. Atherosclerosis

The water extract of multiple parts (fruit, peel, seeds) show antioxidative properties in reducing LDL oxidation with comparable potency, although the seed ethanolic extract seemed to be most potent.[10]

General antioxidant effects beget a reduction in lipid peroxidation, but the practical significance of this information is currently not known

5. Interactions with Glucose Metabolism

5.1. Absorption

The leaves of eriobotrya japonica appear to inhibit sucrase (IC50 values of 2.81mg/mL and 2.87mg/mL basic and fermented leaves, respectively) and maltase (2.24mg/mL and 10.5mg/mL basic and fermented leaves, respectively) activity in vitro, although it appears that they are more notable in enhancing the inhibitory actions of camellia sinensis when fermented in a 1:9 ratio (loquat:green tea).[34] When looking at the ?-amylase enzyme, a water extract of the leaves failed to show any inhibitory properties up to 1mg/mL.[43]

Not overly significant inhibitory effects on carbohydrate (disaccharide) uptake from the intestines, as assessed by its inhibitory effects on the enzymes that break down sucrose and maltose

5.2. Insulin

In isolated pancreatic ?-cells (INS-1) the leaf extract at 320µg/mL is able to stimulate insulin secretion to 260% of baseline, a potency comparable to 1?g/mL glibenclamide.[44] It was noted cinchonain Ib was a causative agent by increasing insulin secretion in the presence of glucose to 122-214% in the concentration range of 10-320µg/mL, and there was a mild increase in plasma insulin (150%) for the four hours following oral ingestion of 108mg/kg cinchonain Ib with no significant influence on blood glucose.[44]

The leaf extract overall suppresses insulin secretion, which was thought to be due to the epicatechin (more prominent than cinchonain Ib in the leaf) since it suppressed insulin secretion in vitro to 57-94% of baseline in the same 10-320µg/mL range.[44]

Despite cinchonain Ib being an insulin secretagogue, the leaf extract appears to suppress the release of insulin from the pancrease by a small amount after oral ingestion possibly related to the epicatechin content

In diabetic rats (alloxan and streptozotocin), supplementation of the total triterpenoid fraction at 100-300mg/kg daily for one week is able to increase insulin concentrations relative to diabetic control by 53-84% (27-43% normalization to nondiabetic control).[45] The flavonoid fragment may be slightly more effective at this particular property, with 300-450mg/kg reducing fasting insulin (44-57% normalization to nondiabetic control) with a similar potency to gliclazide.[46]

May attenuate the reductions in insulin that are seen in some animal models of diabetes

5.3. Blood Glucose

In otherwise normal mice, the triterpenoids (mostly tormentic and corosolic acid) fed over the course of a week can reduce fasting blood glucose (measured in eye socket blood) by 36-44% in the dosage range of 100-300mg/kg, the higher dose being comparable to 50mg/kg gliclazide.[45] The total flavonoids also show blood glucose reducing properties in this context, but require higher doses (300-450mg/kg, with 150mg/kg ineffective) and are less effective than gliclazide.[46]

The leaf extract (25.9% total triterpenoids; 8.7% ursolic acid and 8.2% tormentic acid) fed to mice at 200-1,000mg/kg alongside a high fat diet for four weeks (after a six week high fat run in period) was able to prevent further weight gain associated with reduced food intake, and reduced circulating glucose and improve responses to an oral glucose tolerance test;[5] while this study noted an increase in liver PPAR? in a dose-dependent manner, the increase in AMPK activity of the liver was only present at the lowest dose.[5]

There may be a reduction in blood glucose secondary to attenuating weight gain seen in rodents during a high fat diet, which is known to cause a species-dependent increase in both body weight and parameters such as blood glucose

5.4. Type II Diabetes

Supplementation of eriobotrya japonica (200-1,000mg/kg of an extract with 85.35% total triterpenoids) for four weeks to mice who became obese on a high fat diet was able to reduce fat with no apparent dose-dependence noted, although the improvements in the adipokine profile and insulin sensitivity appeared to be slightly dose-dependent.[47] The potency appeared to be comparable to 10mg/kg rosiglitazone at the highest dose tested for reducing blood glucose and insulin as well as improving insulin sensitivity.[47]

In type II diabetic rats (Otsuka Long-Evans Tokushima) and mice (KK-Ay) given the seed extract at 10% of the diet over the course of four months failed to modify weight gain or either hepatic or plasma lipids yet reduced circulating basal insulin concentrations (halved the difference between diabetic state and control) and significantly abrogated the increase in glucose seen in control groups.[31]

In regards to potential bioactives, amgygladin at doses found in the seed but taken by itself (0.2-2% of the diet) has failed to show any benefit to fasting glucose or insulin[31] and a nerolidol glyoside has noted acute (2-4 hours) reductions in blood glucose in alloxan-induced diabetic rats but not normal rats when ingested at 25-75mg/kg.[21] The total triterpenoid fraction (100-300mg/kg) appears to be effective when isolated from the leaves[45] (particularly euscaphic acid[48]) and the flavonoids (150-450mg/kg) also appear effective;[46] in the context of reducing blood glucose and improving insulin in animal models of diabetes, the triterpenoids (100-300mg/kg) and the flavonoids (150-450mg/kg) seem equipotent.[45][46]

The seeds and leaves appear to have protective effects when given to diabetic animals, with higher than normal doses of these components having comparable efficacy to some antidiabetic drugs (rosiglitazone, gliclazide). This may be mostly due to the triterpenoids of the plant with special reference towards ursolic, euscaphic, and corosolic acids

6. Obesity and Fat Mass

6.1. Adipogenesis

Isolated corosolic acid from eriobotrya japonica at 15-45µg/mL appears to increase glucose uptake into adipocytes by 8.1-18.6% over control cells in the absence of insulin (and to a level significantly lesser than insulin at 1nM as reference), and was augmented in the presence of insulin.[49] Despite the increased glucose uptake, corosolic acid appears to suppress fat accumulation and proliferation associated with suppressing PPAR? and C/EBP? expression.[49]

Corosolic acid has some interesting benefits to adipocytes, but the high concentration required (for triterpenoids at least) paired with the relatively low levels of this in eriobotrya japonica leaves suggest that this mechanism is not relevant following oral ingestion

7. Bone and Joint Health

7.1. Dental Health

In cultured gingival fibroblasts, a 70% ethanolic eriobotrya japonica leaf extract (7.39% Ursolic Acid) was able to suppress an LPS-induced increase in inflammation as assessed by nitrite, TNF-?, and IL-6 when pretreated at 20–80?g/mL; it reached a similar antiinflammatory effect as 2-8?M isolated ursolic acid.[50]

Potential antiinflammatory effects of the triterpenoids may precede anti-inflammatory activities in the gums

8. Inflammation and Immunology

8.1. Interferons and Immunoglobulins

Injections of the hydrophilic (water soluble) leaf extract into mice is able to increase the secretion of IFN-? from the spleen over the next 48 hours when 1-10?g is injected into mice, although there is a suppression at 100?g and while IL-17 is also stimulated it lasts for less than 24 hours; this was also seen with the water insoluble components, but these insoluble components also suppressed TGF-?.[51]

When measuring the serum, it appears that both extracts reduce circulating TGF-? without significantly influencing IL-17, and an increase in IFN-? is seen in lung tissue.[51] The increase in IFN-? from mitogens is also enhanced when whole human blood is incubated with the leaf extract of eriobotrya japonica at 1-100?g/mL with peak efficacy around 1-10?g/mL.[52]

There is an increase in interferons that positively influence immunity, and an increase has been detected in the lungs following administration of the leaf extract

8.2. Macrophages

The leaf extracts (methanolic at 12.5–75µg/mL) of eriobotrya japonica appear to suppress nF-kB activity and MAPK phosphorylation (JNK, ERK, and p38) in macrophages stimulated with LPS and secondary to that suppress iNOS and COX-2 induction, reducing nitrite formation from 9-fold (LPS control) to 2-fold[53] while 500µg/mL of the n-butanolic extract of the leaves (0.7% yield) has been noted to inhibit nF-kB translocation (from LPS) and suppressed nitrite formation by 87.7%.[42] These effects also occur in alveolar macrophages[54] and are thought to underlie some antitussive properties of eriobotrya japonica.

There is an increase in TNF-? and IL-12p70 secretion in whole human blood stimulated with mitogens from 1µg/mL of the leaf extract, while the increase in TNF-? persists up to 10-100µg/mL while IL-12p70 does not; this is indicative of possibly stimulatory effects on macrophages, and reversed the suppression of corticosteroid induced immunosuppression of these cytokines.[52]

May have some currently unexplored modulatory effects on macrophages, since it has been noted to reduce macrophage activation in models of bronchitis and systemic inflammation yet also has a per se stimulatory effect on macrophages and reduces corticosteroid-induced suppression of them

8.3. Mast Cells

A water extract of the leaves of eriobotrya japonica (12.5% yield) in isolated HMC-1 (mast) cells stimulated with the antigen PMA noted that at 100-1,000µg/mL the leaf extract attenuated IL-8 secretion while 1,000µg/mL was required to attenuate TNF-? and IL-6 secretion associated with nF-kB inhibition.[55] Elsewhere, 100-1,000µg/mL of the leaf extract has been found to mildly attenuate the release of histamine in response to an antigen.[56]

This same extract was later found to attenuate compound 48/80 induced anaphylaxis as mortality was halved at 100mg/kg injections and prevented at 500mg/kg, with the preventative effects only occurring when administered prior (as administration of even 1,000mg/kg 20 minutes after compound 48/80 was ineffective).[56]

Potential anti-allergic properties of the leaves and seeds, but this requires quite a high concentration in vitro and the limited animal evidence suggests that a large dose of the supplement is required to exert these antiallergic effects; may not be relevant to standard supplemental doses

8.4. Allergies

The seed extract of eriobotrya japonica (70% ethanolic with 13% yield) given at an unspecified dose (‘5 times greater than the calculated human equivalent’; which according to this study[57] may be 1,250mg/kg) alongside sensitization to antigens (DTNB and oxazolone) and daily thereafter noted a suppression of ear edema by 11.3-19.2% when the rats were reintroduced to the antigens.[58]

Oral ingestion of higher than normal doses of the seed ethanolic extract appear to have mild anti-allergic effects when it comes to contact dermatitis

8.5. Virology

When testing triterpenoids in inhibiting the activation of Epstein-Barr virus, it seems that they had an inhibitory property comparable to the reference (EGCG from Green Tea Catechins).[18]

9. Interactions with Hormones

9.1. Estrogen

Eriobotrya japonica leaf extract has been noted to possess estrogenic effects at a concentration of 100µg/mL which was as potent as 100ng/mL 17?-estradiol in a yeast assay.[59]

Potential interactions with estrogenic signalling of currently unknown relevance to the human body

9.2. Cortisol

The dichloromethane methane of eriobotrya japonica leaves 11?-HSD1 is inhibited (IC50 of 43+/-3µg/mL) preferentially over 11?-HSD2 (88+/-5µg/mL), although both inhibitory effects were weaker than the reference of glycyrrhetinic acid from Licorice.[60]

1,000mg/kg of a leaf extract (85.35% triterpenoids) but not 200-500mg/kg given to mice for four weeks after being fed a high fat diet was able to mildly decrease expression of the 11-?-hydroxysteroid dehydroxygenase 1 (11?-HSD1) gene in the liver and white adipose tissue, despite the expression of this gene not necessarily being altered with the onset of obesity and insulin resistance.[47] This was replicated with the reference drug of 10mg/kg rosiglitazone.[47]

The enzyme that reduces cortisone into the active cortisol appears to be mildy hindered at high oral doses of this leaf, likely not highly relevant to oral supplementation of this leaf

10. Peripheral Organ Systems

10.1. Stomach

A 70% ethanolic extract of the seeds from eriobotrya japonica (dose unspecified) for 14 days with the last dose an hour before indomethacin induced stomach ulceration was able to attenuate the ulceration and oxidative changes[61] and elsewhere the same extract and timing given 15mL of either the human dose (37.5mg per 15mL; or 250mg/kg) or two concentrated forms (three and five times the aforementioned dose) noted reductions in the ulcer index in response to aspirin (31-71% protection), histamine (28-71%), serotonin (60-75%), pylorus ligature (25-43%; nonsignificant), and Alcohol with or without additional hydrochloric acid (39-60% and 34-49%) where the most effective dose of 112.5mg (750mg/kg) was equally effective as Teprenone (25mg/kg twice daily).[57]

Higher than average doses of the ethanolic seed extract appear to be respectably protective against gastric ulceration from a variety of sources based on the limited animal evidence available

10.2. Liver

The leaf extracts of eriobotrya japonica are known to possess antioxidative properties per se (IC50 for reducing lipid peroxidation was 30.35µg/mL) and higher potency with a water extract (10.08µg/mL) or partial ethanolic (15.62µg/mL), all of which appeared to outperform Vitamin E as reference (40.24µg/mL).[62] These antioxidant effects are thought to partially explain hepatoprotective effects against oxidative toxins, such as in rats given hepatotoxicity from dimethylnitrosamine (carcinogen) followed up by oral ingestion of various seed extracts in unspecified doses where there were protective effects (reduced liver enzymes and fibrosis) with all fragments with most potency coming from the 70% ethanolic extract.[63]

Methyl chlorogenate has been noted to suppress nF-kB activity in the liver of rats subsequently given an inflammatory agent via injections (t-butylhydroperoxide), with 2-10mg/kg of methyl chlorogenate suppressing nF-kB activity in a dose-dependent manner and the higher dose not being significantly different than control.[27]

In rats consuming a diet that induces fatty liver (a methionine-choline deficient diet) also given the 70% ethanolic seed extract of eriobotrya japonica (12% yield) at 270mg daily (approximately 2,450-3,000mg/kg) for 15 weeks, there was a full and partial attenuation of changes in the liver enzymes AST and ALT, respectively.[64] The seed extract was also associated with reductions in oxidative stress in liver tissue, fat accumulation in the liver, and subsequent fibrosis.[64]

There are standard protective effects in the liver which may be related to the antioxidant properties of this compound; currently it has not been compared to reference drugs in an assessment of potency

In rats fed a diabetic and obesogenic diet given the seed extract (10% of the diet) which was sufficient to reduce blood glucose and insulin levels, there was no significant influence on hepatic fatty acids or cholesterol concentrations.[31]

The dose that appears to exert beneficial effects towards glucose metabolism has failed to exert any appreciable benefit to cholesterol and lipid content of the liver

10.3. Lungs

One study measuring IFN-? concentrations have noted an increase in lung tissue following injections of 1-10?g of the water soluble extract from eriobotrya japonica leaves[51] and oral ingestion of 150-450mg/kg of the total triterpenoids has been noted to increase lung activity of the superoxide dismutase (SOD) enzyme.[65]

A possible immunostimulatory effect involving an increase in IFN-? has been reported in the lung tissue, and oral ingestion of high doses of the triterpenoids has been confirmed to increase antioxidant enzyme status in lung tissue

In isolated lung epithelial cells (A549) treated with the proinflammatory LPS, the leaf water extract of eriobotrya japonica appears to reduce the secretion of proinflammatory cytokines such as IL-1? (IC50 of 43.5+/-1.56µg/mL; normalized to control at 125µg/mL), TNF-? (33.6+/-1.4µg/mL; normalized to control at 64µg/mL), and IL-8 (35.4+/-1.4µg/ml; normalized to control at 500µg/mL) associated with nF-kB inhibition.[66] These effects were thought to simply be due to Ursolic Acid since it inhibited IL-8 production with an IC50 of 2+/-0.14µM (oleanolic ineffective).[66]

Total triterpenoids of eriobotrya japonica leaf (50-450mg/kg) fed to rats for 28 days after pulmonary fibrosis (induced by an injection of bleomycin A5) was able to alleviate fibrosis in the lungs and trachea, and this alleviation was associated with reductions in both protein content and mRNA of TNF-? and TGF-?1.[14] The doses of 50-450mg/kg were not significantly different than 1.2mg/kg dexamethasone (reference drug)[14] and this dose also appears to be effective in reducing LPS induced inflammation in the bronchus associated with reducing immune cell infiltration[67] and reducing macrophage activity and nF-kB activation in said macrophages.[68] In regards to LPS induced inflammation, all three doses tested (50, 150, and 450mg/kg) are either statistically comparable to each other and to 1.2mg/kg dexamethasome[67] or the two higher dsoes are while 50mg/kg is statistically protective but less so.[68]

Very high doses of the triterpenoids appear to be quite protective against damage in the lungs in response to inflammatory stimuli, but due to the high doses used this may not be practically reflective of oral supplementation of basic extracts

10.4. Kidneys

A 70% ethanolic extract of the seeds of eriobotrya japonica given at 15mL daily (dose unspecified but possibly in the range of 250-500mg/kg) was able to partially attenuate the increases in creatinine and BUN seen with adriamycin toxicity;[69] there was a partial abrogation of lipid peroxidation, and no influence on the reduction in albumin.[69]

Potential protective effects of unknown practical relevance

11. Interactions with Cancer Metabolism

11.1. Mechanisms

A family of molecules that can inhibit apoptosis in the cell (inhibitors of apoptosis proteins, or IAP) has a subset which are X-linked inhibitor of apoptosis proteins (XIAPs) which can bind to caspase-9 from the mitochondria (on XIAP’s BIR3 domain[70]) and prevent caspase-9 from inducing apoptosis. This process is normally inhibited by another protein from the mitochondrial called Smac/DIABLO which interacts with the BIR3 domain and prevents it from influence capsase-9.[71]

A acetylated flavonoid form eriobotrya japonica leaves known as kaempferol-3-O-?-L-(2?,4?-di-E-p-coumaroyl)-rhamnoside appears to bind to the BIR3 domain in an inhibitory manner (ie. is a Smac mimetic) with an IC50 of 10.4?M;[25] it is greatly dependent on the rhamnose sugar and the two coumaric acid moieties, and free Kaempferol does not appear to have this property.[25] Kaempferol itself, however, has been implicated in downregulating the protein content of XIAP[72][73] despite not directly binding to it.

A acetylated flavonoid in this plant appears to be a direct small molecule inhibitor of XIAP function, which may be involved in increasing apoptosis in cancer cells. Due to the unknown content of this molecule in the leaf, it is unknown how relevant this information is

Some triterpenoids in eriobotrya japonica leaves appear to be topoisomerase I inhibitors with most potency coming from 3-O-(E)-p-coumaroyltormentic acid (IC50 of 20.3?M) which was comparable to camptothecin (28.1?M) and stronger than ursolic acid (26.3?M), betulinic acid (36.5?M), oleanolic acid (64.3?M), and maslinic acid (80.6?M).[74]

Some triterpenoid structures may be inhibitors of topoisomerase I; practical significance of this data in regards to supplementation of this supplement is currently unknown

11.2. Invasion and Metastasis

Eriobotrya japonica is able to downregulate MMP2 and MMP9 and subsequently reduce invasion of B16F10 melanoma cells (concentration dependent up to 250-500µg/mL[75]) and MDA-MB-231 breast cancer cells (10-50µg/mL; up to 80% with the leaf extract[76]), which is thought to be due to ursolic acid and 2?-hydroxyursolic acid since they both suppressed MMP2 (to 10% of control) and MMP9 (25% of control) at 1.25µg/mL in a manner associated with reducing nF-kB translocation into the nucleus.[75]

Potential antiinvasive effects secondary to ursolic acid

11.3. Breast Cancer

Eriobotrya japonica (leaf extract with 17.2% yield) appears to have antiproliferative effects in MDA-MB-231 breast cancer cells with an IC50 of 4+/-0.2µg/mL, which was significantly better than its effects on other cancer cells such as cervical HeLa cells (23+/-1.1µg/mL), lung A549 cells (14+/-0.6µg/mL), and ovarian SK-OV-3 cells (306+/-14.2µg/mL).[59]

In vitro preliminary evidence suggests a respectable antiproliferative effect on the invasive breast cancer cell line

11.4. Leukemia

In leukemic cells (HL-60, U937, Jurkat and THP-1), isolated triterpenoids (ursolic, corosolic, oleanolic, and maslinic acids) have shown antiproliferative actions with most potency coming from corosolic and ursolic acids in the concentration range of 6.25-25?M.[77] Corosolic acid was further tested and was noted to induce apoptosis via inducing DNA fragmentation via oxidative stress in a mitochondrial dependent manner associated with increasing Bax translocation into the mitochondria.[77] An acetylated triterpenoid (3-O-(E)-p-coumaroyltormentic acid) has shown similar properties in HL-60 (EC50 of 6.9?M) with a potency comparable to ursolic acid (5?M) and betulinic acid (6.4?M) by inducing apoptosis via the mitochondrial pathway.[74]

Potential benefits which are mostly just secondary to ingestion of ursolic acid

11.5. Sarcoma

In mice bearing Meth-A tumors who are then injected with 0.1mg of an eriobotrya japonica hydrophilic extract, injections do not appear to induce IFN-? secretion from the spleen with a single dose (seen in normal mice) but three repeated daily doses appeared to mildly stimulate IFN-? production with no influence on IL-17 nor TGF-?1.[51]

Despite the above, injections of the water insoluble components greatly increased median lifespan from 27 days in control to 78 days while the water soluble extract failed to prolong lifespan.[51]

11.6. Adjuvant Usage

One study in hamsters where mucositis was induced using 5-fluorouracil, the 70% ethanolic seed extract (54mg; around 640mg/kg) taken daily for a week prior to the drug and continued until the end of the experiment was able to fully prevent leukocyte infiltration and lipid peroxide yet only appeared to attenuate the thickness of mucositis in the cheek tissue by approximately half.[78]

One study has noted benefits to oral mucositis, but it has not been investigated whether this adjuvant treatment benefits or hinders the usage of chemotherapeutics in treating cancer

12. Safety and Toxicology

12.1. General

The n-butanolic extract of the leaves (0.7% total) yield appears to be acutely nontoxic up to 2,000mg/kg oral intake in mice,[42] and when looking at a 70% ethanolic extract (measured in dry leaf equivalents) the leaf appears to have an LD50 of 40.1g/kg bodyweight in mice.[79]

The seed extract given to mice over a period of four weeks at an oral dose of 8,000mg/kg has failed to exert any clinical signs of toxicology.[31]

At this moment in time there is insufficient evidence to suggest absolute safety but no reports of harm assocaited with the supplement; toxicity induced in animals appears to suggest that it is not acutely damaging

Dose: 4.5-12g

Su Zi – Zi Su Zi – Perilla seed

Nature: acrid, warm

Enters: Lung, Large Intestine

Actions: Descends Lung Qi; stops coughing, eases difficult breathing; mildly resolves phlegm; moistens the large intestine, promotes bowel movement.

Indications:
• Lung Qi fails to descend: coughing, wheezing, including patterns with copious phlegm. Used mainly for cold patterns. Especially indicated when the exhale is more labored than the inhale and there is a stifling sensation in the chest.
• Dryness of the large intestine: constipation.
• Compared to Bai jie zi and Lai fu zi: All are capable of transforming phlegm, regulating the Qi, and alleviating wheezing. However, Bai jie zi warms the Lung Qi, Lai fu zi disperses the Lung Qi, and Su zi descends the Lung Qi.
• Usually ground before use.

Dose: 4.5-9g

Sang Bai Pi – Morus bark – “Mulberry White Bark”

Nature: sweet, cold

Enters: Lung, Spleen

Actions: Drains Lung heat (to the bladder); stops coughing, eases difficult breathing; promotes urination, reduces edema.

Indications:
• Lung heat: cough with copious phlegm and difficult breathing.
• Edema related to an excess syndrome.
• Lung heat obstructs the descent of Lung Qi, preventing water from moving and cutting off perspiration: floating edema, facial edema, swelling of the extremities, fever, thirst, difficulty in urination, floating pulse.
• Hypertension: moderately lowers blood pressure.
• Honey fry when using the herb for coughing and wheezing.
Hsu: Diuretic, sedative, hypotensive.
DY: Disinhibits urination and disperses swelling without damaging Yin; eliminates evils from the Qi division.
• With Chen pi to clear the Lungs and transform phlegm, rectify the Qi, stop coughing and calm asthma. For cough and asthma due to Lung heat with abundant yellow phlegm.
• With Di gu pi to clear the Yin and Qi divisions, to effectively clear heat and drain fire from the Lungs, eliminate deficiency fire damaging the Lungs, stop cough, and calm asthma. For the following indications, the combination is found in Xie Bai San:
– 1. Cough and asthma with expectoration of yellow, sticky, and thick phlegm, fever and thirst due to Lung heat.
– 2. Cough accompanied by evening fever or low but persistent fever with skin which is warm to the touch due to deficiency heat damaging the Lungs.
– For the above indications, honey mix-fried Sang bai pi should be used. This combination can treat both full and deficiency heat. The Lungs are a delicate viscus and are easily damaged by heat. Full heat easily damages Lung Yin, causing both full and deficient heat simultaneously. This pair addresses this situation very well. In case of full heat, add Huang qin, Pi pa ye, and Zhe bei mu. In case of deficiency heat, add Zhi mu and Mai men dong.

Dose: 6-15g

Ting Li Zi – Descurainia or Lepidium seed

Nature: bitter, acrid, very cold

Enters: Lung, Bladder

Actions: Strongly promotes urination, moves water, relieves edema; resolves phlegm; clears heat; descends Lung Qi; calms wheezing.

Indications:
• Lung phlegm accumulation or Lung heat: cough with copious sputum, difficulty breathing, gurgling sound in the throat.
• Lungs fail to dominate the water passages or excess-type obstruction of Lung and bladder Qi: facial edema, fluid accumulation in the chest or abdomen, urinary difficulty.
• For hydrothorax, combine with Xing ren and Mang xiao.
• Large doses have produced a cardiotonic effect in various animals (positive ionotropic effect and negative chronotropic effect – increases cardiac output and reduces venous pressure).
Liu: Not for deficiency. Its purgative function is as strong as rhubarb – can damage the Qi.
Hsu: Purgative; expectorant, alleviates pharyngitis, facilitates removal of phlegm from throat.
DY: With Da zao to powerfully drain the Lungs, disinhibit urination, and drastically evacuate phlegm without damaging Yin or the stomach. Together, they downbear Qi and calm asthma. For indications such as asthma, cough with stertor, wheezing, a swollen face, and oliguria due to accumulation of phlegm in the Lungs. (Ting Li Da Zao Xie Fei Tang)
• There are two types of Ting li zi:
Tian ting li is sweet and comes from the south. Its draining and dispersing properties are moderate. It drains the Lungs and expels phlegm without damaging the stomach.
Ku ting li is bitter and comes from the north. This is the most currently prescribed in clinical practice and the most effective. Its draining action is strong. It strongly drains the Lungs and expels phlegm and can damage the stomach. In order to slow down the drastic action of this herb, it can be stir-fried until scorched. Also, its combination with Da zao is essential.

Dose: 3-9g

Xing Ren – Apricot seed – Prunus

Nature: bitter, slightly warm, slightly toxic

Enters: Lung, Large Intestine

Actions: Descends the Lung Qi, stops coughing, eases difficult breathing; moistens the large intestine, promotes bowel movement.

Indications:
• Lung fails to descend its Qi: cough, difficulty breathing. Appropriately combined, this herb can be used for either hot or cold patterns. It is the especially useful for externally contracted dry coughs, and coughs which are accompanied by wheezing.
• Dryness of the large intestine: constipation
• Topical: grind to a powder and mix with water to form a paste. Apply locally for acne, dog bites, trichomonas vaginitis.
• Forms a cyanide compound (hydrocyanic acid) in the body: lethal dosage for adults is approximately 50-60 kernels, and in children about 10 kernels. Cooking it, removing the outer coating, and mixing it with sugar all reduce its toxicity. Overdose can be treated with administration of activated charcoal and syrup of ipecac [Cephaelis ipecacuanha]. The bark of the apricot tree and the cortex of its root have also been used traditionally as antidotes. Use cautiously with infants.
• The type most often used are the bitter kernels which grow in northern China, called “bitter apricots” – Ku xing ren – or “northern apricots” – Bei xing ren. Sometimes, especially in the treatment of dry or deficient coughs, the sweet apricots grown in southern China are used. These are called “sweet apricots” – Tian xing ren – or “southern apricots” – Nan xing ren.
DY: The slight toxicity of Xing ren is located in the superficial skin and the tip of the seed. The preparation of Dan xing ren (scalded apricot seed) by removing the tip and skin, considerably reduces the risk of toxicity.
Tian/Nan xing ren (the sweet, southern type) is sometimes used – it is not toxic, and is favored for asthma and cough of the deficiency type and dry constipation.
• With Chuan bei mu to moisten while transforming phlegm, downbear the Qi, and stop cough. For indications such as:
– 1. Chronic cough and/or dry cough with little or no phlegm, difficultly expectorating, and dry throat due to Lung vacuity.
– 2. Relentless cough with expectoration of yellow phlegm due to external evils or an accumulation of phlegm-heat in the Lungs.
• With Jie geng to effectively regulate the Lungs’ function of dispersing and descending, to transform and disperse phlegm, stop cough, and calm asthma. For such indications as cough and/or asthma with chest oppression, profuse phlegm, sore throat, and aphonia due to an attack of external wind (wind-cold or wind-heat) that disturbs the diffusion and downbearing function of the Lungs.
– Both herbs have the function of dispersing and descending the Lung Qi, however, Jie geng mainly disperses while Xing ren mainly descends. Both herbs transform and disperse phlegm, however, Xing ren mainly transforms while Jie geng mainly disperses (promotes expectoration of) phlegm.
Hsu: Expectorant, antitussive, emollient, laxative.

Dose: 3-9g

The Warmer Phlegm-Resolving Herbs Start Here

The herbs in this category are neutral or warm. They are used mostly for cold phlegm, phlegm-dampness, or phlegm in a neutral environment, without the presence of heat.  However, they are sometimes used even for the treatment of phlegm-heat (when combined with cooling herbs), because their acrid, warmer natures make many of them very powerful drying herbs for eliminating phlegm.

Also consider, as appropriate: herbs the resolve phlegm-heat, herbs that drain dampness, herbs that warm the interior, herbs that promote Qi and blood circulation, herbs that release the exterior, herbs that stop coughing and wheezing, etc.

Bai Fu Zi – Typhonium rhizome – “White Appendage”

Nature: acrid, sweet, warm, toxic

Enters: Spleen, Stomach, Liver

Actions: Eliminates both internal and external wind; relieves convulsions; dries dampness; resolves phlegm; eliminates toxicity; disperses stagnation of phlegm, dissipates nodules; stops spasms; expels wind-cold-dampness; alleviates pain.

Indications:
• Wind-phlegm: Bell’s palsy, migraine, tetanus, dizziness, deviation of the mouth and eyes in wind-stroke. Specific for phlegm problems of the face and head – enters the Yangming stomach channel.
• Phlegm and toxicity: snake bite, masses, scrofula or other nodules. Often used topically.
• Wind-cold-dampness: dizziness, severe lateral headaches, numbness, facial pain, facial weakness, or any head pain with signs of damp-cold or wind-dampness.
• Some effectiveness against tuberculosis.
• In Northern China, the root of Aconitum coreanum is used as this herb. It is known as Guan bai fu, and it should not be confused with Typhonium since it is very toxic. If you buy this herb (as I have) and it looks just like white Fu zi, it probably is.
Hsu: Analgesic, tranquilizer.

Dose: 1.5-6g

Bai Jie Zi – White Mustard seed

Nature: acrid, warm

Enters: Lung

Actions: Warms the Lungs, eliminates phlegm; promotes Qi circulation, dispels Qi stasis; removes phlegm from the channels and collaterals; dissipates nodules, reduces swelling, alleviates pain.

Indications:
• Phlegm-cold accumulation: Coughing copious and thin sputum, difficulty breathing, distention and pain in the chest and hypochondriac region, hydrothorax.
• Phlegm(-cold) obstruction in the channels and collaterals: multiple abscesses, carbuncles, lymphoma, joint pain, body aches, yin-type boils, bedsores, watery, oozing sores. A valuable herb for the treatment of any kind of pain when phlegm or dampness obstructs the channels and collaterals.
• Often applied as a plaster for asthma (on BL-13, 15, 17) – promotes local blood circulation.
• Topical: for lumps and pain. Long Western history of use in baths and plasters for pain. Caution: may cause blistering of the skin. Do not use on patients with skin sensitivities.
• Must be crushed before using.
• Compared to Su zi and Lai fu zi: All are capable of transforming phlegm, regulating the Qi, and alleviating wheezing. However, Bai jie zi warms the Lung Qi, Lai fu zi disperses the Lung Qi, and Su zi descends the Lung Qi.
Li: Very warming.
PCBDP: Rubefacient, counter-irritant, stimulant, diuretic, emetic.
• Externally used for rheumatic pains and bronchitis.
Hsu: Expectorant: the oil slightly irritates the gastric mucosa, causing slight nausea which reflexively increases the bronchial secretions needed to expel phlegm.
• Topical: decreases pain and inflammation.

Dose: 3-9g

Bai Qian – Cynanchum root and rhizome – “White Before”

Nature: acrid, sweet, neutral

Enters: Lung

Actions: Strongly eliminates phlegm; descends Lung Qi, relieves coughing.

Indications:
• Lung Qi stagnation and failure to descend: cough with thick, sticky sputum, gurgling in the throat, wheezing, difficulty breathing.
• Not drying.
• Combine with acrid herbs for wind-cold or wind-heat
Bai qian’s ability to descend rebellious Lung Qi is similar to, but weaker than, Ma huang’s. Bai qian can be used to treat wheezing and coughing in patients who are not strong enough to tolerate Ma huang.
DY: This herb “disperses” phlegm – xiao tan – close to the Western idea of expectorating phlegm.
• Can be used in the treatment of almost every type of cough. Due to its neutral nature, it can be used for coughs due to either cold or heat.
• With Qian hu, for mutual reinforcement in dispersion of phlegm. They complement each other to downbear (mainly via Bai qian) and diffuse (mainly via Qian hu) the Lung Qi in order to effectively treat cough. For such indications as: cough with abundant phlegm or phlegm which is difficult to expectorate, itchy throat, chest oppression due to blockage of the Lung Qi and Lung Qi counterflow. The combination can be used in the treatment of numerous respiratory diseases: chronic bronchitis, dyspnea, asthma, whopping cough, cough associated with a cold, etc.
• In case of cough due to wind-cold or wind-heat, the uncooked form of the herb should be prescribed.
• In case of cough caused by an accumulation of phlegm in the Lungs, the herb should be stir-fried until scorched.
• In case of chronic cough, dryness in the Lungs, or if the patient is old, use the honey mix-fried form of the herb.

Dose: 3-9g

Ban Xia – Pinellia rhizome – “Half Summer”

Nature: acrid, warm, slightly toxic

Enters: Lung, Stomach, Spleen, Gallbladder, Heart

Actions: Resolves phlegm; dries dampness; descends rebellious stomach Qi, harmonizes the stomach, stops vomiting; dissipates lumps and distention, disperses swelling and relieves pain.

Indications:
• Phlegm-damp (especially when originated in the spleen): cough with copious sputum.
• Rebellion of stomach Qi (including from stomach phlegm-damp): nausea, vomiting.
• Phlegm obstruction: pressure, distention in the chest or epigastrium, plum pit sensation, masses, carbuncles, phlegm nodules in the neck (including goiter, scrofula), or other obstruction caused by phlegm anywhere in the body.
• Compared to Bei mu, Ban xia is more effective for phlegm-damp, while Bei mu is more for phlegm-heat. Ban xia is better at transforming phlegm lodged in the stomach, while Bei mu is better at transforming phlegm in the Lungs. The two are often used together to mutually enhance each other’s therapeutic properties.
• Tincture of Ban xia was effective in treating 95% of cases of acute toothache.
• Effective in acute suppurative otitis media.
Ban xia is always prepared for internal use with ginger, alum, or vinegar. Prepared Ban xia is called Fa ban xia. The ginger-prepared form is specifically referred to as Jiang ban xia. That prepared with alum is called Qin ban xia.
• Raw Ban xia is toxic and is only used externally to reduce ulcerations, deep-rooted sores, and carbuncles.
• Overdose can generally be cured with oral administration of raw ginger.
• Contraindicated in combination with aconite products.
• Must be crushed before use.
• Ban xia qu is powdered and fermented Ban xia with Gan cao. It promotes digestion and resolves phlegm. It is particularly good when food stagnation has led to phlegm accumulation.
Li: Ban xia is a nice addition when treating the Ren Mai (e.g. chronic UTI), as it opens all the channels. It is vital for lower Jiao problems.
• The Chong and Ren Mai connect with the Yangming. Therefore, moving stomach Qi with Ban xia helps unblock the Chong and Ren.
MLT: One of the strongest antitussives; stops post-nasal drip and excessive saliva.
• Avoid the form prepared with Ming fan (Alum) since it may have a cumulative toxic effect.
PFGC: Ban xia can open up coagulations; can revive accidental death victims when the powder is blown up the nose.
Ban Xia Tang can resolve insomnia by restoring proper communication between the body’s Yin and Yang aspects.
Ban xia can be considered to open the orifices.
Ban xia contains the storing and descending momentum of autumn metal: can pull things down, can calm the Chong Mai
Ban xia can relieve paralysis caused by wind-cold-damp.
• Alum-processing destroys its pungency and can induce nausea rather than treating it.
• It is best to buy unprocessed Ban xia, soak it in hot water for 10 days changing the water daily, then cut it into halves, put it in fresh cold water, bring it to a boil, remove it from heat, let it cool, and then dry it.
CHA: (Karen S. Vaughan) While our materia medicas list about 10 functions of Ban xia, only about two of them apply to any given preparation. Fa ban xia, for instance (usual preparation) rectifies spleen deficiency, harmonizes the stomach, and deals with insubstantial phlegm leading to vertigo, insomnia or delirious speech. Jiang ban xia is needed to deal with nausea, vomiting, rebellious Qi and coughs due to colds with phlegm. Qing ban xia is necessary for coughs with damp, phlegmy Bi syndrome, especially with nodulations or long-standing conditions without nodulations. Zhu li ban xia is used for serious mental disturbances such as schizophrenia.
Hsu: Strong antiemetic – decreases excitation of the vomiting center in the brain. Ban xia also has an emetic component which is destroyed by heating it. Furthermore, this toxic compound is quite insoluble in water.
• Sedative.
• Slightly decreases pressure inside the eye.
Heiner Fruehauf and Chip Chace: Articles by Zhang Xi-chun indicate that Ban xia has a slippery nature that helps supplement both the spleen and kidney. By removing phlegm-damp, it helps restore the normal spleen qi, and by disinhibiting dampness, helps supplement the kidney. Zhang Xi-chun says that when the pungent nature of ban xia is used to counteract phlegm or damp, the normal moistening actions of spleen and kidney are benefitted. “Just as Cheng Wuyi has put it: “˜Pinellia is pungent and dispersing; it moves water and thus moistens kidney dryness. In other words, if dryness counteracts dampness, water becomes uninhibited, and if pungent flavors transform fluids, the dryness becomes moist.’ He also says that it is used for vacuity constipation in the elderly, therefore, it is a mistake to say that it is excessively drying.” [from Z’ev Rosenberg]
DY: Fortifies the spleen; disperses food accumulation.
• With Chen pi for mutual reinforcement, to fortify the spleen, rectify the Qi, dry dampness, transform phlegm, and stop vomiting. For such indications as:
– 1. Cough due to an accumulation of phlegm-dampness. (Use lime-processed Ban xia.)
– 2. Chest oppression, nausea, and vomiting due to stomach disharmony and phlegm-damp stagnation. (Use ginger-processed Ban xia and stir-fried Chen pi.)
– Both herbs are traditionally cured to reduce secondary effects and reinforce their therapeutic actions. The longer they are kept, the more effective they become.
• With Huang lian to harmonize upbearing and downbearing, Yin and Yang, to clear heat, dry dampness, transform phlegm, and stop vomiting. For indications such as nausea, vomiting, chest and epigastric fullness and distention, thick, yellow phlegm, yellow, slimy tongue fur, and a wiry, slippery pulse due to damp-heat, turbid phlegm, and/or mixed cold and heat causing stomach disharmony. Huang Lian Tang is typically used. For these indications, ginger-processed Ban xia and ginger mix-fried Huang lian should be used.
• With Huang qin to harmonize and re-establish the interaction between Yin and Yang, to effectively clear heat, drain fire, harmonize the stomach, stop vomiting, and scatter nodulation. For such indications as:
– 1. Vomiting and nausea due to a Shaoyang pattern. (Xiao Chai Hu Tang) Use ginger-processed Ban xia. When Ban xia is removed from Xiao Chai Hu Tang, the alternating fever and chills disappear, but the pain and distention of the chest and lateral costal regions persist.
– 2. Phlegm-heat. (Qing Qi Hua Tan Wan) Use lime-processed Ban xia and win mix-fried Huang qin.
– 3. Lack of appetite, nausea, vomiting, and distention and sensation of fullness in the stomach, diaphragm, and chest caused by a pattern of mixed cold and heat. (Ban Xia Xie Xin Tang) Use ginger-processed Ban xia and bran stir-fried, ginger mix-fried or stir-fried-until-scorched Huang qin.
• With Sheng jiang to transform phlegm, downbear counterflow, harmonize the stomach, and stop vomiting. For such indications as:
– 1. Nausea, vomiting with not thirst and slimy tongue fur due to phlegm-dampness stagnating in the middle burner. (Xiao Ban Xia Tang) Ginger-processed Ban xia should be used.
– 2. Enduring cough with white, watery, and profuse phlegm. Use lime-processed Ban xia.
• With Shu mi (Millet) to transform phlegm, harmonize the stomach, and quiet the spirit. For such indications as insomnia with heart palpitations, nausea, and cough with thin phlegm due to phlegm-dampness accumulation in the middle burner causing stomach disharmony. Ban xia and Shu mi are probably the best combination to treat insomnia due to stomach disharmony, i.e. stagnant food preventing the defensive Qi from entering the interior.
• With Zhu ru for mutual reinforcement, to effectively dry dampness, clear heat, transform phlegm, harmonize the stomach, and stop vomiting. For such indications as:
– 1. Hiccup, nausea, and vomiting due to counterflow of stomach Qi. (Use ginger-processed Ban xia and ginger mix-fried Zhu ru.)
– 2. Vertigo, agitation, and insomnia due to phlegm turbidity. (Use lime-processed Ban xia and ginger-processed Zhu ru.)
– 3. Nausea and vomiting during pregnancy due to disharmony of the stomach, phlegm-heat, or heat in the stomach. In cases of stomach disharmony, add Zi su geng and Sha ren. In cases of stomach cold, add Sheng jiang and Sha ren. In cases of phlegm-heat, add Pi pa ye. In cases of stomach heat, add Bai mao gen and Pi pa ye.
Ban xia is incompatible with mutton, sheep blood, and maltose.

Dose: 4.5-12g

Jie Geng – Platycodon root – Balloon Flower root

Nature: bitter, acrid, neutral

Enters: Lung

Actions: Disperses Lung Qi; eliminates phlegm; drains pus; benefits the throat; guides herbs upward.

Indications:
• Cough with copious sputum or less, difficult-to-expectorate sputum, chest congestion, hoarse voice, sore throat. Combined appropriately, it can be used for both wind-cold and wind-heat coughs.
• Sore throat, loss of voice – especially when due to external heat, but also when due to other factors, such as phlegm-heat or Yin deficiency heat.
• Lung abscess or throat abscess: cough with a mixture of pus, blood, and yellowish, foul sputum.
• This is the premier herb for dispersing stagnant Lung Qi.
Hsu: Expectorant – promotes saliva and bronchial secretions; antitussive; antifungal; tranquilizer; analgesic; antipyretic; anti-inflammatory; vasodilator; hypotensive.
DY: Guides other herbs to the Lungs, chest, and the Lung channel. Jie geng can raise herbs which otherwise have a tropism for the lower burner towards the middle or upper burner. Loosens the diaphragm. Mainly upbears but also downbears.
• Can be used to treat the upper body (Lungs – the superior origin of fluids) for certain lower body problems (oliguria, dysuria, anuria).
• With Gan cao to clear heat, transform phlegm, disinhibit the throat and stop pain, evacuate pus, and resolve toxins.
– 1. Pulmonary abscess with cough, expectoration of profuse, purulent phlegm, and chest oppression and pain due to heat stasis in the chest. (Jie Geng Tang)
– 2. Pain, redness, and swelling of the throat due to heat (deficient or excess, external or internal).
– 3. Loss of voice and/or hoarse or husky voice.
– For indications 2 and 3, the combination can be reinforced by adding He zi, as in He Zi Tang. For these indications, in cases of Lung dryness, honey mix-fried Jie geng should be used.
• With Xing ren to effectively regulate the Lungs’ function of dispersing and descending, to transform and disperse phlegm, stop cough, and calm asthma. For such indications as cough and/or asthma with chest oppression, profuse phlegm, sore throat, and aphonia due to an attack of external wind (wind-cold or wind-heat) that disturbs the diffusion and downbearing function of the Lungs.
– Both herbs have the function of dispersing and descending the Lung Qi, however, Jie geng mainly disperses while Xing ren mainly descends. Both herbs transform and disperse phlegm, however, Xing ren mainly transforms while Jie geng mainly disperses (promotes expectoration of) phlegm.
• With Zhi ke to effectively regulate upbearing and downbearing, regulate the upper and middle burners, diffuse the Lung Qi, and loosen the chest and diaphragm. For indications such as:
– 1. Chest and diaphragm oppression or distention or chest Bi due to accumulation of phlegm and Qi stagnation. (Jie Geng Zhi Ke Tang)
– 2. Epigastric distention, stomach rumbling, and difficult defecation due to disturbance of ascending and descending. Note: Zhi ke and Jie geng do not moisten the intestines, do not soften the stools, and do not precipitate the bowels. However, Zhi ke moves and descends the Qi in the large intestine in order to improve evacuation of the stools, while Jie geng disperses and descends Lung Qi. When the Lung Qi correctly descends, the large intestine Qi does the same. Therefore, although Zhi ke and Jie geng do not have a direct action on peristalsis, they can treat constipation due to Lung-large intestine Qi stagnation. Hence, this pair may be used to advantageously reinforce any formula that specifically treats constipation.
Jie geng is incompatible with pork, seaweed, and Chinese cabbage.

Dose: 3-9g

 
Gan Jie Geng: Adenophora tracheloides – “Sweet” Jie geng
• Cold.
• Moistens the Lungs; clears heat; relieves fire toxicity.
• See its relative, Nan sha shen.
• When Jie geng is specified, Platycodon – Ku jie geng (“bitter” Jie geng) is implied. It is much more commonly used than Adenophora.

Xuan Fu Hua – Inula flower – Elecampane – “Revolved, Upturned Flower”

Nature: bitter, acrid, salty, slightly warm

Enters: Lung, Spleen, Stomach, Large Intestine, Liver

Actions: Descends the Qi of the Lungs and stomach, stops vomiting and burping; resolves phlegm and harmful fluids; promotes blood circulation, frees the connecting vessels; free the liver Qi and subdues the liver.

Indications:
• Vomiting or burping, especially when due to spleen damp, spleen/stomach deficiency cold, or stomach phlegm.
• Lung phlegm accumulation: cough with copious sputum, wheezing.
• Retention of harmful fluid in the Lungs: distention in the chest and diaphragm.
• Qi and blood stagnation: distending pain in the costal or hypochondriac area.
• Liver Qi stagnation or liver invading the middle Jiao.
• Anti-emetic, anti-nauseant. Good for nausea after chemotherapy.
• Honey fry the herb for patients with Lung deficiency to ameliorate its warmth and prevent it from harming the Qi or Yin.
• Liu: this is the only flower in the Chinese pharmacopeia which does not disperse (it descends).
MLT: The root and flower are similar, but the root is probably more Qi tonic than the flower.
• Contains quercetin and isoquercetin – both useful for upper respiratory allergies.
DY: Usually flowers have an upbearing, floating nature. However, Xuan fu hua, on the contrary, downbears the Qi and disinhibits urination.
• The flower (Xuan fu hua) and stem (Xuan fu geng) of this plant have similar actions. However, Xuan fu geng is superior for downbearing the Qi and disinhibiting urination, while Xuan fu hua is superior for dispersing phlegm, downbearing the Qi, and calming asthma.
• With Dan nan xing to clear heat, transform phlegm, stop cough, calm asthma, extinguish wind, and wash away phlegm in the channels and network vessels. For indications such as:
– 1. Cough, asthma, and chest oppression due to phlegm-damp obstruction, phlegm-heat, or stubborn phlegm in the Lungs.
– 2. Numbness in the limbs due to (wind) phlegm in the channels and network vessels.
– In the absence of heat, and in the presence of cold or damp patterns, processed Tian nan xing may be favorably prescribed instead of Dan nan xing.
Yoga: Pushkaramula: (root and flower) K, V-; P+
• Expectorant, antispasmodic, carminative, analgesic, rejuvenative.
• For colds, asthma, cardiac asthma, pleurisy, dyspepsia, cough, nervous debility
• A rejuvenative tonic to the lungs. Promotes longevity of lung tissue, helps absorb water from the lungs, reduces swelling.
• Calms the mind, the digestive system, and the female reproductive system.
• Topical: apply as a paste for muscular pain.
MW: The plant told him, in a dream, that its flowers could be used for grief.
• It is said that where Helen of Troy’s tears fell, this plant grew.

Dose: 3-12g (flower)

 
On the common related Western herb, Elecampane root:
K&R: Expectorant, alterative, choleretic, diuretic, pituitary stimulant, sympathomimetic, vagolytic.
• Water, wood, fire, earth, metal deficiency.
• Strengthens and cleanses the mucosa of the gastrointestinal and respiratory tracts.
• Good for glandular insufficiency, immune deficiency, renal insufficiency.
Metal: bronchorrhea, pertussis, copious expectoration, asthma, emphysema, tuberculosis, immunoallergic pneumopathies, sarcoidoses, anemia, leukorrhea, insufficient menses, amenorrhea, dermatoses, chronic diarrhea.
Water: oliguria, edema, glomerulonephritis, acute and chronic arterial hypertension.
Wood: choleretic, immune stimulant, hepatomegaly, herpes, insufficient bile secretion.
Fire: hypotension, lipothymia, syncope from vagotonia, stimulates pituitary and testicular activity, FSH and LH-like activity.
Earth: splenomegaly, gastroptosis, gastric atony, chronic diarrhea, hypothyroidism, insufficient hypophysial function, amenorrhea, impotence, frigidity.

Zao Jiao – Gleditsia fruit – Chinese Honeylocust – “Soap Thorn”

Nature: acrid, warm, slightly toxic

Enters: Large Intestine, Lung

Actions: Powerfully dispels phlegm; opens the orifices, promotes resuscitation; dissipates clumps, reduces swellings; suppository: unblocks the bowels and expels roundworms

Indications:
• Phlegm: obstruction, phlegm nodules, coughing or wheezing with copious, difficult-to-expectorate sputum.
• Excessive phlegm: sudden unconsciousness with facial paralysis or seizures.
• Initial stage of abscesses and boils, or abscesses with pus that is difficult to discharge.
• Suppository: for constipation and intestinal obstruction due to roundworms.
• Increases secretions in the stomach and respiratory tract. Significant expectorant effect, though not as strong as that of Jie geng.
Hsu: Strong hemolytic actions; antibacterial; antifungal; expectorant.

Dose: 0.6-1.5g in pill and powder form only

Zao Jiao Ci – Gleditsia spine/thorn

Nature: acrid, warm

Enters: Liver, Stomach

Actions: Reduces swellings; discharges pus; promotes blood circulation; reduces abscesses; expels wind; kills parasites.

 

Indications:

• Add to formulas for masses (uterine fibroids, tumors, etc.) to break the surface of the mass.
• Used during early stages of swollen sores to encourage suppuration or to induce those that have already closed to burst. Not for use with ulcers that have already burst.
• Leprosy.
• Ringworm.

Dose: 3-9g

Cooling Phlegm-Resolving Herbs Begin Here

Several herbs in this category can be used for either hot or cold patterns when combined appropriately. Even when there is phlegm-heat, the warm and neutral herbs in the previous category (Herbs that Resolve Phlegm-Cold) are often used in combination with heat-clearing herbs.

Also consider, as appropriate:
• herbs that promote Qi and/or blood circulation
• herbs that drain dampness
• herbs that clear heat (including damp-heat and heat-toxins)
• herbs that release the exterior
• herbs that stop coughing and wheezing
• herbs that tonify Qi and/or Yang when deficiency is present

Chuan Bei Mu – Tendrilled Fritillaria bulb – “Shell Mother from Sichuan”

Nature: bitter, sweet, slightly cold

Enters: Lung, Heart

Actions: Moistens Lungs; clears heat; resolves phlegm; stops coughing; resolves masses and lumps.

Indications:
• Phelgm-fire nodules, sores, swellings, scrofula, Lung or breast abscess.
• Possibly the most effective herb for cough in the Chinese pharmacopeia. Useful for many types of cough, mainly chronic cough with Yin deficiency fire, cough with slight sputum that is difficult to expectorate, or cough with blood-streaked sputum.
• Lung yin deficiency: prolonged cough with little sputum and dry throat.
• Milder than Zhe bei mu and therefore more appropriate for children.
• More effective than Zhe bei mu at transforming phlegm and moistening the Lungs.
• Most effective in treating cough accompanied by constrained Qi, manifesting in a reduced appetite and a stifling sensation in the chest and upper abdomen.
• Quite expensive: therefore, it is generally powdered and taken uncooked along with a decoction.
• For dry Lungs: core an Asian pear and fill the center with powdered Chuan bei mu. Replace the top of the plug of pear flesh so the pear is sealed, steam lightly, then eat the whole thing.
• These herbs are always used in their processed form, since they are toxic in their raw state.
• Not to be used with Aconite products.
• Both forms can be very useful in the treatment of heartburn and GERD.
Hsu: Antitussive, expectorant.
• Alkaloids have atropine-like action – decrease secretions, stop contraction of bronchial smooth muscle, dilate pupils.
• Inhibits the CNS, stimulates heart muscle.
DY: Moistens, treats enduring, chronic coughs – such as due to Yin deficiency or dry heat.
• With Zhi mu to clear and moisten the Lungs, enrich Yin, drain fire, transform phlegm, and stop cough. For such indications as:
– 1. Enduring dry cough with little phlegm and difficult expectoration, sometimes fever, dry mouth, and a dry, red tongue due to water deficiency causing rising fire or due to Lung Yin deficiency. (Use stir-fried Zhi mu)
– 2. Cough due to Lung heat which causes Lung dryness.
• With Xing ren to moisten while transforming phlegm, downbear the Qi, and stop cough. For indications such as:
– 1. Chronic cough and/or dry cough with little or no phlegm, difficultly expectorating, and dry throat due to Lung vacuity.
– 2. Relentless cough with expectoration of yellow phlegm due to external evils or an accumulation of phlegm-heat in the Lungs.
Article by Eric Brand on differentiating Chuan Bei Mu from the mediocre substitute Ping Bei Mu.

Dose: 3-12g or 1-3g directly as powder

Zhe Bei Mu – Non-tendrilled Fritillaria bulb – “Shell Mother from Zhejiang”

Nature: bitter, cold

Enters: Lung, Heart

Actions: Dispels stagnant heat and phlegm; stops coughing; resolves masses and lumps.

Indications:
• Phelgm-fire nodules, sores, swellings, scrofula, Lung or breast abscess.
• Both forms of Bei mu are always used in their processed form, since they are toxic in their raw state.
• Not to be used with Aconite products.
• Both forms can be very useful in the treatment of heartburn and GERD.
• Compared to Chuan bei mu, this form is used more for acute Lung wind-heat/phlegm-heat: cough with yellow, sticky sputum.
• Stronger than Chuan bei mu at clearing heat and dissipating nodules, swellings, and difficult-to-expectorate phlegm.
• Clears hot phlegm from the ear, as in pediatric otitis media.
DY: More often used for acute, full, or external type coughs.
Hsu: Antitussive, expectorant.
• Alkaloids have atropine-like action – decrease secretions, stop contraction of bronchial smooth muscle, dilate pupils.
• Inhibits the CNS, stimulates heart muscle.

Dose: 3-9g

Dan Nan Xing – Prepared Arisaema rhizome – Jack-in-the-Pulpit

Nature: bitter, cold

Enters: Lung, Liver, Spleen

Actions: Strongly resolves phlegm and dries dampness; disperses swelling, relieves pain; disperses wind-phlegm in the channels; eliminates both internal and external wind, relieves convulsions.

Indications:
• Wind-phlegm obstructing channels: numbness, paralysis, convulsions, tremors, seizures, stroke, opisthotonos, lockjaw.
• Stubborn phlegm: cough, distended sensation in the chest.
• Good for stubborn phlegm. Treats phlegm over the whole body.
• Topical: for swelling and pain, deep-rooted sores, injuries, ulcers, carbuncles.
• Often used in pediatrics.
• Extremely drying in nature.
Dan nan xing is prepared by soaking Tian nan xing in Ming fan (alum), Sheng jiang (ginger), and ox/pig bile.
• I chose to list Dan nan xing, rather than Tian nan xing, as the primary herb here (with Tian nan xing below), because in the U.S., Tian nan xing is rarely used. However, it is usually presented as subordinate to Tian nan xing.
Li: Dan nan xing is one of the best herbs for phlegm-heat throughout the whole body.
MLT: Stimulant, expectorant, diaphoretic, irritant (Tian/raw).
Hsu: Sedative, antispasmodic, expectorant, antitumor activity (inhibits growth).
DY: With Xuan fu hua to clear heat, transform phlegm, stop cough, calm asthma, extinguish wind, and wash away phlegm in the channels and network vessels. For indications such as:
– 1. Cough, asthma, and chest oppression due to phlegm-damp obstruction, phlegm-heat, or stubborn phlegm in the Lungs.
– 2. Numbness in the limbs due to (wind) phlegm in the channels and network vessels.
– In the absence of heat, and in the presence of cold or damp patterns, processed Tian nan xing may be favorably prescribed instead of Dan nan xing.

Dose: 3-9g

 
Tian Nan Xing:

Nature: bitter, acrid, warm, toxic

Enters: Liver, Lung, Spleen
• In its raw, unprepared form, is very toxic and is mainly used as a topical application for yin-type abscesses, trauma-induced swelling and pain, and swelling of the joints. When used internally, it is always treated (usually with fresh ginger) which greatly reduces its toxicity. If numbness of the tongue is experienced after ingestion, granulated sugar can be taken as an antidote.
Zhi nan xing, the treated form (not Dan nan xing), is somewhat less toxic than raw. It is used mainly for wind-stroke (also see indications of Dan nan xing above). If one simply asks for Tian nan xing, Zhi nan xing is the form that will be given at a pharmacy. It is not to be used internally if it still has its outer skin.

Dose: 4.5-9g (treated); 0.3-1g (untreated, in pills and powders only)

Fu Hai Shi (Fu Shi, Hai Fu Shi) – Pumice – Or occasionally Costazia skeleton (an aquatic invertebrate similar to coral) – “Float on the Sea Stone”

Nature: salty, cold

Enters: Lung

Actions: Softens and resolves hardness and masses; promotes urination; clears Lung heat; resolves phlegm.

Indications:
• Lung heat: cough with thick, sticky sputum or coughing up blood.
• Phlegm: masses, nodules, scrofula.
• Hot or stony painful urinary dysfunction – urinary tract infection, kidney or bladder stones.
• Pumice is very light – some say it can slightly disperse Lung Qi.
• To promote urination, grind into a powder and take directly.
• When decocting, place it in a tea bag.
• History of use as an abrasive for softening skin, and more recently in spas as a powder as an exfolliant.

Dose: 6-15g

Gua Lou – Trichosanthes whole fruit

Nature: sweet, cold

Enters: Lung, Stomach, Large Intestine

Actions: Moistens the Lungs and Large Intestine; promotes bowel movement; promotes healing of sores; clears phlegm-heat; expands and promotes Qi circulation in the chest; clears Lung heat.

Indications:
DY: Sweet, cold, moistening, clearing, downbearing; clears the Lungs; transforms phlegm; loosens the chest, scatters nodulations; moistens dryness, moistens the intestines; promotes Qi circulation; loosens the chest and diaphragm and frees the flow of impediment.
• Though Gua lou is sweet and cold, it is used for chest Bi due to Qi stagnation and blood stasis and/or chest Yang deficiency. Though Gua lou is sweet, it does not supplement, nor produce Qi stagnation. Though it is cold, it does not cause obstruction. In cases of chest Yang deficiency or stagnation, Gua lou is combined with herbs that balance its cold nature, such as Xie bai, Bai jiu, Gui zhi, and Tan xiang.
• With Xie bai to effectively free the flow of Yang and move the Qi, loosen the chest and clear the Lungs, transform phlegm and scatter nodulation, stop pain, moisten the intestines, and free the flow of the stools. For indications such as:
– 1. Constipation due to fluid dryness of the large intestine and/or Qi stagnation.
– 2. Yin binding constipation. (Constipation due to spleen-kidney Yang deficiency or sometimes due to dryness in the large intestine caused by an essence-blood deficiency with pale lips, white tongue fur, and clear, copious urination.)
– 3. Chest Bi with oppression of the chest and epigastrium, cough, profuse phlegm, piercing pain in the chest radiating toward the back, and shortness of breath due to accumulation of turbid phlegm blocking the Qi and Yang of the chest. (Gua Lou Xie Bai Ban Xia Tang – which can be favorably combined with Er Chen Tang) Use Gua lou which has been stir-fried until scorched.
– 4. Chest Bi and cardiac disease with intense heart pain due to heart Qi and blood stasis and deficiency of heart Yang. (Gua Lou Xie Bai Bai Jiu Tang) For these indications, the combination can be favorably reinforced by adding Dan shen, San qi, Tan xiang, and Gui zhi. The Gua lou should be stir-fried until scorched.

Dose: 10-20g

Gua Lou Pi – Trichosanthes peel

Nature: sweet, cold

Enters: Lung, Stomach, Large Intestine

Actions: Promotes Qi circulation in the chest; clears Lung heat; eliminates phlegm, moistens.

Indications:
• Lung heat: cough with thick and sticky sputum, including dry coughs with difficult-to-expectorate sputum.
• Lung phlegm-heat: distention or pain in the chest.
• Qi accumulation in the chest: stifling or distended sensation, constriction, pain, diaphragmatic pressure.
• Painful obstruction of the chest, Lung abscess, breast abscess.
• May help break down granulomas.
Gua lou pi is less moistening than Gua lou ren.
• Not to be used with Aconite products.
Li: Stronger than Gua lou ren to open the chest.
MLT: Same energetics as the whole fruit (Gua lou), but better for dry throat, cough, and wind-heat-phlegm that is difficult to expectorate.

Dose: 9-30g

Gua Lou Ren – Trichosanthes seed

Nature: sweet, cold

Enters: Lung, Stomach, Large Intestine

Actions: Moistens the Lungs and large intestine; promotes bowel movement; promotes healing of sores; clears phlegm-heat; expands the chest.

Indications:
• Large intestine dryness: constipation – especially when accompanied by Lung heat with dry mouth, thirst, and irritability.
• Lung heat/phlegm-heat: cough with thick, sticky, difficult-to-expectorate sputum, chest pain.
• Accumulation of phlegm in the chest: stifling sensation, pain, diaphragmatic pressure.
• Adjunct herb for breast abscesses, swellings, and for sores that have not yet suppurated.
Gua lou – the whole fruit – is similar in effect to the seed, but is less effective at lubricating the intestines, transforming phlegm, and dissipating nodules.
• Not to be used with Aconite products.
MLT: Dry constipation associated with thirst.
Hsu: Antibacterial, anti-cancerous – mild inhibitory action on tumors.

Dose: 10-15g

Hai Zao – Sargassum – Black tangly seaweed

Nature: salty, cold

Enters: Liver, Stomach, Kidney, Lung

Actions: Softens masses; resolves phlegm; promotes urination, reduces edema.

Indications:
• Phlegm accumulation: masses, lumps, neck nodules – goiter, scrofula.
• Adjunct herb for edema due to leg qi or floating edema.
• Pain associated with hernial disorder.
• Stronger than Kun bu to promote urination.
• May soften atherosclerosis.
• Contains iodine – caution with hyperthyroidism (when due to iodine excess).
• May lower cholesterol.
Li: With Kun bu, also with Gui ban: for polycystic kidneys, all cysts and swellings, inner ear phlegm. Also for some thyroid problems.
MLT: Often used with Kun bu for swollen glands (especially the thyroid) and tumors.
SD: Heavy metal poisoning: has been shown to bind heavy metals.
Hsu: Anticoagulant [when decocted] (this component possesses same action as heparin [about half the strength]), antifungal, hypotensive, lowers serum cholesterol.

Dose: 4.5-15g

Huang Yao Zi – Dioscorea bulbifera tuber – “Yellow Medicine”

Nature: bitter, neutral, toxic

Enters: Heart, Liver, Lung

Actions: Dissipates nodules, reduces masses; cools the blood, stops bleeding; reduces toxicity of toxic swellings.

Indications:
• Masses: many kinds of cancer, especially those involving the esophagus, stomach, uterus, and colon; also for goiter.
• Bleeding: hematemesis, hemoptysis, uterine bleeding.
• Topical: sores, snake bite, dog bite.
• Thyroid tumors: tinctures and decoctions have been used in many clinical series for thyroid tumors, including endemic goiter and thyroid cancer. It has been most effective in treating nonmalignant tumors of short duration in relatively young patients. Side effects included nausea and vomiting that required cessation of treatment. There are also recorded cases in which tinctures led to significant liver dysfunction and jaundice.
• Esophageal and gastric tumors: in one series of 28 cases, tinctures of Huang yao zi improved symptoms in 18 cases. In a few cases there were adverse effects on the liver.
• Often taken in wine, or directly in pill or powder form.
• To avoid hepatotoxicity, the herb is given only for a few weeks at a time (while monitoring liver function). It may be resumed after a break.

Dose: 6-15g

Kun Bu – Kelp thallus – Ecklonia – Kombu – OR Laminaria (Hai Dai – which possesses nearly the same properties)

Nature: salty, cold

Enters: Liver, Stomach, Kidney

Actions: Softens masses and nodules; resolves phlegm; promotes urination, reduces swelling.

Indications:
• Phlegm: swellings, masses, nodules in the neck, sensation of fullness and obstruction in the chest.
• Adjunct herb for edema and leg qi.
• Stronger than Hai zao at resolving phlegm and soften masses.
• Shown to have an anti-asthmatic and antitussive effect in many animals.
• Contains iodine – caution with hyperthyroidism (when due to iodine excess).
• Useful in treating both hyperthyroidism (temporarily improves the symptoms) and hypothyroidism (due to a lack of iodine).
• Extracts of this herb and Undaria have been used for their fucoxanthin content as a non-stimulating thermogenic supplement for weight loss.
SD: Heavy metal poisoning: has been shown to bind heavy metals.
K&R: Earth, metal, and water yin.
• Glandular stimulant, remineralizer.
• Treats obesity and cellulite by nourishing thyroid function.
• Rich in minerals and nutrients for various deficiencies.
• Retarded development, anorexia, emaciation, asthenia, anemia, frigidity, impotence.
• Strengthens a weak constitution for chronic problems like asthma, emphysema, sinusitis, arthritis, collagenoses, chronic dermatoses, amenorrhea, oligomenorrhea, hypothryroidism, polyneuritis, paralysis.
• Adjunct herb for autoimmune disorders, degenerative disease, cancer.
MLT: Long Western tradition for regulation of the thyroid and for weight reduction (due in part to high iodine).
• Binds toxins to help their excretion.
Hsu: Antitussive, expectorant, hypotensive (slight, temporary).

Dose: 4.5-15g

Meng Shi – Mica or Lapis – Chlorite-Schist

Nature: sweet, salty, neutral

Enters: Lung, Liver

Actions: Calms the liver, relieves convulsions and palpitations; descends the Lung Qi; resolves phlegm.

Indications:
• Stubborn phlegm: cough and difficulty breathing with old, viscous, clumped phlegm.
• Liver wind stirring, phlegm-heat: convulsions, palpitations, seizures, mania-withdrawal.
• Severe food stagnation.
• Bensky/Gamble classifies as an herb to stop cough and wheezing.
Duan meng shi, the calcined form, is more easily absorbed then the raw form.

Dose: 9-15g

Pang Da Hai – Boat Sterculia seed – “Fat Big Sea”

Nature: sweet, cold

Enters: Lung, Large Intestine

Actions: Clears heat and disperses Lung Qi; clears large intestine heat; promotes bowel movement; encourages the expression of rashes (topical use).

Indications:
• Lung heat: hoarse voice, sore throat, tonsilitis.
• Lung phlegm-heat: cough.
• Heat and dry feces in the colon: constipation with concurrent headache, red eyes, and feverish body.
• Good for the combination of hoarse voice with constipation.
• Use alone in hot water for hoarseness/sore throat and watch its metamorphosis.
• Topical: as an external wash for incomplete expression of rashes.
Hsu: Strongly inhibits influenza viruses; laxative (when eaten) by absorption of a large amount of water into colon; hypotensive; diuretic; analgesic.

Dose: 4.5-9g

Qian Hu – Peucedanum root – Hogfennel – “Before Barbarians”

Nature: bitter, acrid, slightly cold

Enters: Lung

Actions: Descends Lung Qi; eliminates phlegm; mildly disperses wind-heat.

Indications:
• Lung heat or Lung Qi stagnation with failure of the Lung Qi to descend: cough with thick and sticky sputum, wheezing.
• Wind-heat or wind-cold: cough, copious sputum. Most often for wind-heat.
• Can be used with Chai hu for externally-contracted diseases presenting with cough, rebellious Qi, thick sputum, and/or malarial disorders.
DY: With Bai Qian, for mutual reinforcement in dispersion of phlegm. The two herbs complement each other to downbear (mainly via Bai qian) and diffuse (mainly via Qian hu) the Lung Qi in order to effectively treat cough. For such indications as: cough with abundant phlegm or phlegm which is difficult to expectorate, itchy throat, chest oppression due to blockage of the Lung Qi and Lung Qi counterflow. The combination can be used in the treatment of numerous respiratory diseases: chronic bronchitis, dyspnea, asthma, whopping cough, cough associated with a cold, etc.
• In case of cough due to wind-cold or wind-heat, the uncooked form of the herb should be prescribed.
• In case of cough caused by an accumulation of phlegm in the Lungs, the herb should be stir-fried until scorched.
• In case of chronic cough, dryness in the Lungs, or if the patient is old, use the honey mix-fried form of the herb.
Hsu: Dilates coronary artery; expectorant – stimulates secretions of the respiratory tract (effect similar to Jie geng, but weaker antitussive action); antihistamine action.

Dose: 4.5-9g

Tian Zhu Huang – Siliceous Secretions of Bamboo – Tabasheer – “Heavenly Bamboo Yellow”

Nature: sweet, cold

Enters: Heart, Liver, Gallbladder

Actions: Clears heat and resolves phlegm to calm the Shen and ease convulsions; stabilizes fright.

Indications:
• Lung phlegm-heat: difficult-to-expectorate sputum.
• Phlegm-heat: convulsions, spasms. Especially useful for childhood convulsions.
• Wind-stroke due to phlegm accumulation: gurgling sound in the throat.
• Mental disturbances due to fright.
• Compared to Zhu li, Tian zhu huang is gentler and less cold, and is therefore more appropriate for children.
• The fully natural product is rare. Heat is usually applied to the bamboo, the secretions are collected from a node and then crystallized.
Yoga: Vamsha-rochana (includes Zhu ru): P, V-; K+
• Demulcent, expectorant, tonic, rejuvenative, antispasmodic, hemostatic; nurtures the heart, soothes the nervous system.
• For colds, cough, fever, asthma, bleeding disorders, emaciation, debility, dehydration, palpitations, vomiting, consumption.
• Helps Lung weakness, helps recovery from chronic disease.
• Strong anti-Pitta herb.

Dose: 3-9g (0.6-1.2g taken directly)

Ze Qi – Euphorbia helioscopia – “Marsh Lacquer”

Nature: acrid, bitter, cool, slightly toxic

Enters: Large Intestine, Small Intestine, Lung

Actions: Transforms phlegm; stops cough, arrests wheezing; dissipates nodules; promotes urination, strongly reduces edema.

Indications:
• Lung heat with phlegm and congested fluids: coughing, wheezing.
• Scrofula: used both internally and topically (as a wash, paste, or powder).
• Edema in the upper abdomen, face and eyes, and extremities.
• Bacillary dysentery: In one study of 79 cases, oral preparations markedly improved 44 cases and improved 13.
• Esophageal cancer: In one study of 64 cases (using IM injection of a 20% solution of neutral saponins), in terms of their ability to swallow, 10 cases were cured, 18 were markedly improved, 30 were improved. Results were generally noted within five days. The herb had no effect if the patient had previously undergone radiation therapy.

Dose: 3-15g

Zhu Li – Dried Bamboo Sap

Nature: sweet, very cold

Enters: Heart, Lung, Stomach

Actions: Clears heat, transforms phlegm, penetrates to and unblocks the channels; transforms phlegm-heat, stops coughing.

Indications:
• Phlegm obstructing sensory (heart) orifices: fainting, paralysis of the hands or feet, hemiplegia, coma.
• Phlegm-heat: Cough. Used in small doses as powerful adjunct herb.
• Channel obstruction: spasms of the extremities.
• Take directly. May be mixed with ginger juice to offset its cold nature (as when used in a large dose for coma).
• Compared to Tian zhu huang, Zhu li is extremely cold and slippery in nature, and therefore is very effective in clearing heat and moistening excessive dryness.

Dose: 30-90g (9-15g for cough)

MLT: Important in the preparation of Sito Paladi Churna (Ayurvedic cold/cough remedy):
• Take 8 parts Zhu li, 16 parts raw brown sugar, 1 part cinnamon (Rou gui), 4 parts black pepper (Hu jiao), 2 parts cardamom (Sha ren).
• Grind into a powder.
• Take 1 teaspoon at a time with warm water or milk.
• Strongly warming, clears mucus, helps digestion.

Notes on This Category

• Some herbs in this category only drain dampness, while others both drain dampness and clear heat.
• Some herbs in this category have the potential to damage Yin or Qi. Be cautious with Yin or Qi deficiency.
• Herbs in this category are frequently combined with:
A. Herbs that relieve exterior syndromes and promote sweating when there is edema and an exterior syndrome simultaneously.
B. Herbs that warm the kidneys and spleen when there is Yang deficiency of these organs.
C. Herbs that clear heat and reduce fire when there is both dampness and heat.
D. Herbs that stop bleeding when there is bleeding due to heat forcing blood out of the vessels.

Bi Xie – Tokoro rhizome – Fish-Poison Yam – Dioscorea hypoglauca or D. tokoro (and other species)

Nature: bitter, neutral

Enters: Liver, Stomach, Bladder

Actions: Strongly drains damp; eliminates wind-dampness; clears damp-heat from the skin; separates the pure from the turbid; relaxes the sinews, unblocks the connecting channels.

Indications:
• Dampness: painful urination with turbid urine (like rice porridge) or vaginal discharge (can be used for problems due to either deficiency or damp-heat).
• Wind-damp or damp-heat: Bi syndrome, lower back pain, numbness or stiffness of the lower extremities, muscle aches. (mild effect)
• Damp-heat accumulation at the skin: skin lesions such as eczema, pustular sores.
• In cases of damp-heat induced painful urinary dysfunction, this herb is most appropriate when dampness is predominant.
MLT: Antibacterial, antifungal, antirheumatic, anti-inflammatory, antitussive, antiparasitic.
• Similar to Western wild yam (D. villosa) – for damp-heat: jaundice, hepatitis, and gallbladder and rheumatic diseases.
SD: May help antidote lead poisoning.

Dose: 9-15g

 
May bear some similarities to Western Wild Yam – Dioscorea villosa:
JC: Antispasmodic, relaxant, stimulant, antibilious, diaphoretic, expectorant, diuretic, hepatic, cholagogue, stomachic, tonic, anti-emetic, antirheumatic, anti-asthmatic, emetic (large dose).
Good for pain.
RW: Contains diosgenin – a precursor used in the synthesis of progesterone and other steroids.
PLB: Studies indicate that orally consumed diosgenin is not converted to progesterone in the human body. Does not have hormonal effects.
IBIS: Anodyne, anti-inflammatory, antirheumatic, antispasmodic, cholagogue, diaphoretic.
• [Western] dosage: tincture: 1 – 2 mL. powder: 400 – 800 mg.
• Specific indications: bilious colic; skin and conjunctiva yellow, with nausea and colicky pain; tongue coated, stomach deranged, and paroxysmal pain in the abdomen; twisting or boring pain, radiating from the umbilical region, with spasmodic contraction of the belly muscles; colic with tenderness on pressure, which gives relief to the spasmodic action (Felter and Scudder, p. 344)
• Therapy: indigestion; dysenteric tenesmus; cholera morbus; ovarian neuralgia; spasmodic dysmenorrhea; nausea of pregnancy; after-pains; obstinate and painful vomiting; gastralgia (Felter and Lloyd, p. 660); intestinal colic; diverticulitis; rheumatoid arthritis; muscular rheumatism; cramps and intermittent claudication; cholecystitis; dysmenorrhea; ovarian and uterine pain (British Herbal Pharmacopoeia, p. 79)
• Contraindicated during pregnancy due to teratogenic potential (Brinker, p. 43)
• Contraindicated in peptic ulcers; long term use may potentiate ulcers and/or prevent their detection.
• Caution is advised in patients with history of recent surgery, diabetes, hypoglycemia, nephrotic syndrome, urinary tract infections, acute infectious hepatitis, leukemias, Graves’ disease, or related genetic disorders (Langer and Greer, pp. 66 – 67); caution is also advised for those with thyroid problems, as studies indicate a possible goitrogenic response (Langer and Greer, p. 79).
• Large doses cause nausea, vomiting, diarrhea (Spoerke, p. 149; Felter and Lloyd, p. 661)

Bian Xu – Polygonum aviculare – Knotweed

Nature: bitter, slightly cold

Enters: Bladder

Actions: Stops itching; clears damp-heat; promotes urination; unblocks painful urinary dysfunction; kills parasites.

Indications:
• Damp-heat in the lower Jiao: painful urination.
• Damp-heat: skin disorders with itching, including tinea.
• Intestinal parasites: tapeworm, hookworm, pinworm.
• Douche for trichomonas.
• Topical: wash for surface parasites.
• Also for bacillary dysentery.
• Increases the tension of the uterus – used to stop postpartum uterine hemorrhage.
• In cases of damp-heat induced painful urinary dysfunction, this herb is most appropriate when dampness and heat are equally severe.
MLT: Common weed around the world, used widely for urinary tract inflammation.
TS: The gravel remedy. Its chief influence is on the bladder and it has been known to remove stones from the bladder when all other treatment had failed. It will prevent the formation of gravel when there is a tendency, and it frequently dissolves stones already formed. It is desirable to combine it with Equisetum.
Hsu: Antibacterial, hypotensive, anthelmintic.

Dose: 9-15g

Che Qian Zi – Plantago seed – “Before the Cart Seeds”

Nature: sweet, cold

Enters: Kidney, Liver, Lung, Bladder

Actions: Drains dampness and harmful body fluid by promoting urination (without damaging Yin); clears heat from the liver; brightens the eyes (mildly nourishes Yin); clears heat and resolves phlegm from the Lungs (mild); stops coughing; normalizes malpositioned fetus (at 8 months); mildly nourishes Jing; solidifies the stool (by promoting urination).

Indications:
• Bladder damp-heat: scanty urination, painful urination, edema.
• Liver heat: red, painful, swollen eyes, photosensitivity.
• Liver and kidney Yin deficiency: blurry vision, cataracts, dry eyes.
• Summer-heat with dampness: diarrhea.
• Can be used alone for any diarrhea (usually does not address the root).
• Scanty milk after childbirth.
• Female infertility: strengthens the Jing of kidneys and liver.
• Lung heat: cough with copious sputum.
• Injection into joint spaces has the effect of tightening overly lax joint capsules. This effect has been used clinically in treating recurring dislocation of the temporomandibular joint.
• In one study, in which Che qian zi was used in treating 68 cases of malpositioned fetus diagnosed at eight months, 90% of the subjects had a normal presentation at birth.
• Often put into a bag for cooking, to keep it from floating or passing through the strainer.
• Often dry-fried when used to promote urination.
• Often fried in wine when used for kidney deficiency.
Hsu: Antitussive, expectorant.

Dose: 4.5-9g

 
Che Qian Cao: entire plant
• Sweet, cold.
• Not as effective as the seed in promoting urination, but more effective at clearing heat and it also eliminates toxicity.
• Used internally and topically in the treatment of abscesses and swellings.

Dose: 9-30g

K&R: (various parts of the plant): Astringent, diuretic, sympathomimetic, pituitary stimulant.
• Wood excess, wood deficiency, earth deficiency, metal deficiency.
• Inflammation of the kidneys, gonorrhea, associated low back pain, eye diseases, Lung Yang deficiency, bronchitis, laryngitis.
Wood: conjunctivitis, allergic rhinitis, allergic asthma, allergic eye conditions.
Metal: emaciation, retarded development, bronchitis, laryngitis, tuberculosis, constipation, chronic diarrhea, leukorrhea, eczema, acne.
Earth: strengthens stomach and upper digestive functions; for malnutrition, retarded development, nephrotic syndromes.
JC: (root, leaves, flower spikes, seeds of Plantago major or P. lanceolata)
• Alterative, depurant, diuretic, emollient, mildly astringent, refrigerant, deobstruent, antiseptic, vulnerary, antivenomous, styptic, antisyphilitic, anthelmintic (vermicide).
• The roots and leaves have moderately diffuse and stimulating alterative effects on the circulatory system. They also assist the glandular system, healing lymph and epidermal areas in scrofulous and skin diseases.
• Excellent for kidney and bladder disorders.
• An effective remedy for poisonous bites and stings.
• The best herb for blood poisoning: reduces swelling and heals limbs where amputation seems imminent.
• Eases pain and heals the lower intestinal tract.
• Diarrhea, glandular swellings, hemorrhoids, piles, kidney and bladder disorders, lumbar pain, scanty urine, enuresis, edema, scrofula, syphilis, thrush.
• Douche for leukorrhea, menorrhagia.
• Topical: for bleeding, use as a poultice and drink. Use as a wash for malignant or bleeding ulcers, toothache, burns, scalds, erysipelas, inflamed eyes. Wash with a strong infusion for itching, ringworm, old wounds.

Chi Xiao Dou – Aduki bean – Phaseolus calcaratus – “Little Red Bean”

Nature: sweet, sour, neutral

Enters: Heart, Small Intestine

Actions: Promotes urination to relieve edema; clears heat; eliminates toxicity; drains pus; dispels blood stasis; reduces swelling; clears damp-heat, treats jaundice.

Indications:
• Retention of harmful fluid: edema with distended abdomen, urinary difficulty, leg qi edema.
• Blood stasis, fire toxicity: carbuncles, sores, furuncles.
• Damp-heat: jaundice.
• Topical: combine with egg white, vinegar, and honey, and apply to carbuncles and boils due to damp-heat.

Dose: 9-30g

Deng Xin Cao – Rush pith – Juncus – “Lamp Wick Herb”

Nature: sweet, bland, slightly cold

Enters: Heart, Lung, Stomach

Actions: Drains dampness by promoting urination; clears heat from the heart channel – descends heart heat to the small intestine.

Indications:
• Hot, painful or dark, scanty urine.
• Pediatric sleep disorders with dark, scanty urine and irritability, especially at night.
• Heart and kidney not communicating (due to heart fire with kidney Yin deficiency): insomnia or restless sleep.
MLT: Specific for urinary tract infections, sore throat, damp-heat, incessant crying of babies.

Dose: 1.5-4.5g

Di Fu Zi – Kochia fruit – “Earth Skin Seeds”

Nature:  bitter, cold

Enters: Bladder

Actions: Stops itching; clears heat; drains dampness, promotes urination.

Indications:
• Damp-heat: skin disorders such as eczema, scabies and other dermatological problems where itching is a major symptom. Also for damp-heat in the external genitalia. Good with Huang bai. Can be used both internally and topically for skin problems.
• Damp-heat in the lower Jiao: painful urination, dark, burning, scanty urine.
• Not to be used in combination with Hai piao xiao.

Dose: 6-15g

Dong Gua Ren – Benincasa seed – Winter Melon seed – Wax Gourd seed

Nature: sweet, slightly cold

Enters: Lung, Large Intestine, Stomach, Small Intestine

Actions: Clears heat; expels phlegm; promotes discharge of pus; promotes urination; drains dampness.

Indications:
• Heat in the Lungs or intestines: expectoration of thick, yellow sputum, etc.
• Damp-heat with phlegm obstruction in the upper or lower Jiao: intestinal abscess, Lung abscess – when the patient is exhausted easily, scar tissue surrounds the abscess and antibiotics cannot get through.
• Especially useful in the treatment of damp-heat vaginal discharge.
• Topical: grind and use the powder as sunscreen.

Dose: 3-12g

Dong Kui Zi – Dong Kui Guo – Muskmallow seed – Malva verticalla or Abutilon seed / Velvetleaf seed

Nature: sweet, cold

Enters: Large Intestine, Small Intestine, Bladder

Actions: Promotes lactation, benefits the breasts; moistens the intestines; drains dampness and heat; promotes urination, unblocks painful urinary dysfunction.

Indications:
• Damp-heat in the lower Jiao: painful, hot, bloody, or stony urination.
• Retention of harmful body fluid: edema.
• Insufficient fluids in the intestines: constipation with dry and hard stool.
• Insufficient lactation, painful swollen breasts, early stages of breast abscess.
• Especially useful for urinary/edema disorders accompanied by constipation.
MLT: Similar to Western Althea/Marshmallow [mainly used for its soothing mucilaginous properties] – for irritated urination from dryness.
• Milder than Hua shi.
• Demulcent; increases richness of mother’s milk.

Dose: 6-15g

Fu Ling – Poria sclerotium (mushroom) – Hoelen – Tuckahoe – Includes Fu Shen, Fu Ling Pi, Chi Fu Ling, Fu Shen Xin

Nature: sweet, bland, neutral

Enters: Heart, Spleen, Kidney, Lung

Actions: Drains dampness and harmful body fluid by promoting urination; tonifies spleen Qi; calms the Shen; transforms phlegm; harmonizes the middle Jiao.

Indications:
• Spleen Qi deficiency with dampness: loose stool, fatigue, poor appetite.
• Stagnation of fluids or dampness: edema, scanty urination, difficult urination, diarrhea.
• Retention of harmful body fluid in the spleen: dizziness, palpitations, cough, headache (The spleen Qi is prevented from lifting to the head: dizziness, headache; from lifting to the heart: palpitations; and from lifting to the Lungs: cough.)
• Shen disturbance: insomnia, palpitations, forgetfulness (Fu shen may be preferable).
• Said to promote longevity.
• Reduces blood sugar.
• Drains without harming the Qi or Yin.
• Weight loss: can be powdered and mixed 50/50 with powdered rice, then dry fried into a “cookie” with small amount of sweetener, eaten as main food.
• Compared to Yi yi ren, Fu ling’s tonic effect is much stronger. But unlike Yi yi ren, Fu ling does not treat wind-dampness.
PFGC: Balances earth; transforms stomach phlegm-rheum into useful body fluids; can bank earth and engender metal – beneficial to both the stomach/spleen and Lungs; stops excessive sweat loss.
• “The Qi of the pine tree enters the earth, where, after a long time, it forms hoelen. the material quality of hoelen is formed by Yin Qi, while it has been conceived by Yang.”
• Purely benevolent, always tonifying.
• Key herb for excessive sweats causing palpitations causing insomnia.
• Hoelen settles kidney water rushing up to fill the void of depleted heart fluid (use a large dose in critical situations).
Li: Commonly uses up to 30g/day for severe dampness. Combines large doses of Fu ling with non-greasy Yin tonics (such as Huang jing) when there is both dampness and Yin deficiency.
MLT: High in potassium salts, which may be responsible for its fluid regulating properties.
Frees interstitial fluid for excretion and regulates intercellular fluid – unlike most diuretics, it does not cause thirst.
PCBDP: Contains several acids shown to be cytotoxic to hepatoma in vitro.
DY: With Bai zhu, the two herbs reinforce each other to effectively supplement the spleen and dry dampness, percolate dampness, and disinhibit urination. For such indications as:
– 1. Edema due to accumulation of dampness, due in turn to spleen deficiency. (Bai Zhu San)
– 2. Fatigue, weakness in the limbs, lack of appetite, loose stools or diarrhea caused by spleen deficiency with accumulation of dampness. (Shen Ling Bai Zhu San)
– 3. Vertigo, blurred vision, and/or heart palpitations due to phlegm-dampness. (Ling Gui Zhu Gan Tang)
– 4. Chronic cough due to phlegm-dampness and spleen deficiency. (Liu Jun Zi Tang)
• With Yi zhi ren to fortify the spleen, secure the kidneys, reduce urination, and stop diarrhea. For indications such as:
– 1. Strangury with chyluria, milky, turbid urine, and dysuria due to deficiency cold in the kidneys or kidney Qi not securing with imbalance in the function of transformation of the bladder. (Use salt mix-fried Yi zhi ren)
– 2. Diarrhea due to deficiency cold of the spleen and kidneys. Particularly watery diarrhea. Use Yi zhi ren which has been stir-fried until scorched.

Dose: 9-15g (up to 60g for acute facial edema)

Fu Ling is the generic term for the entire mushroom, which consists of:
• Fu Ling Pi: the blackish “bark.”
– More diuretic, slightly tonic.
– Frees urination without affecting the Qi.
– Disperses swelling, treats edema and oliguria caused by severe accumulation of dampness due to spleen deficiency.
Dose: 15-30g.

• Chi Fu Ling: the pinkish flesh just beneath the blackish bark.
– Drains heat, frees urination.
– For strangury, oliguria, and red or dark urine due to damp-heat.
Dose: 5-15g

(Bai) Fu Ling: the white flesh which comprises most of the mushroom.
– Tonic and moderately draining.
– Frees urination, tonifies the spleen, quiets the Shen.
– For edema, oliguria, and phlegm due to spleen deficiency.
– For nausea and vomiting due to damp stagnation in the middle Jiao.
– For loss of appetite due to spleen deficiency.
Dose: 5-15g

Fu Shen: the flesh which surrounds the parasitized root.
– Stronger at quieting the Shen than Fu ling. Calms the heart, quiets the spirit.
– For insomnia, disturbed sleep, palpitations, loss of memory.
HF: (Fu Shen) An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas because emotional disturbance is common in patients with Gu.
Dose: 5-15g

Fu Shen Xin: the parasitized pine root at the heart of the mushroom.
– Strongest at quieting the Shen.
– Tranquilizes the heart, calms the liver, drains wind and dampness.
– For insomnia, cardiac pain, spasms of the sinews.
Dose: 5-10g

Hai Jin Sha – Japanese Fern spores – Lygodium – “Sea Gold Sand”

Nature: sweet, cold

Enters: Bladder, Small Intestine

Actions: Drains dampness and heat by promoting urination.

Indications:
• Damp-heat and/or stones in the lower Jiao: painful urination with blood or turbidity.
• This herb is superior for pain relief (urinary).
• Often cooked in a bag to keep from floating to the surface.
DY: Frees strangury; clears heat from the small intestine, bladder, and blood division.
• With Ji nei jin to free strangury, transform stones, and, therefore, treat stone strangury. For stone strangury and urinary lithiasis due to damp-heat. This combination can be reinforced by combining it with Jin qian cao, Hua shi, Qu mai, and Che qian zi.
• With Jin qian cao for mutual enhancement, to strongly clear heat and eliminate dampness, disinhibit urination, free strangury, and expel stones. For indications such as:
– 1. Stone and/or sand strangury, renal lithiasis, bladder lithiasis. For these indications, the combination can be enhanced by adding Ji nei jin, Che qian zi, Dong gua ren, and Qu mai.
– 2. Gallstones due to damp-heat in the gallbladder. For this indication, the combination can be reinforced by adding Yin chen hao, Yu jin, Jiang huang, Qing pi, and Hu zhang.

Dose: 6-15g

Jin Sha Teng: the herb – “Gold Sand Vine”
• Sweet, cold.
• Clears heat; promotes urination; relieves fire toxicity.
• Damp-heat: painful urinary dysfunction, especially with stones or blood.
• Painful, swollen throat or mumps.
• Bensky/Gamble: clear heat and relieve toxicity category.

Hua Shi – Talcum – “Slippery Stone”

Nature: sweet, bland, cold

Enters: Stomach, Bladder

Actions: Drains dampness and heat by promoting urination; clears heat and releases summer-heat; absorbs dampness.

Indications:
• Damp-heat in the lower Jiao: scanty, dark, burning and painful urination; diarrhea.
• Summer-heat: restlessness, thirst, fever, urinary difficulty.
• Damp-heat: diarrhea, distention of the chest.
• Qi level heat with dampness: unremitting fever, a heavy feeling in the body, thirst, yellow tongue coat.
• Topical: for damp skin lesions, eczema, boils, itching.
• Doctrine of signatures: Use stone for stones. Hua shi’s slippery quality frees the orifices and also helps kidney stones “slip” out of the body.
• Contraindicated for spermatorrhea due to kidney deficiency – this herb is too slippery and may exacerbate the problem.
• Place in a tea bag when decocting.
NOTE: This herb should probably be made obsolete, since it likely contains asbestos and is a known cause of gastric cancer, and – when inhaled – of lung cancer.
DY: Above, it clears the origin of water (i.e. the Lungs) and downbears Lung Qi; below, it frees the flow of the water passages and opens the bladder; eliminates evil heat in the six bowels.
• Since it is heavy and slippery and therefore favors descent, is not advisable in pregnancy (it might cause the fetus to slip), except to hasten delivery.
• With Gan cao: Gan cao can moderate the cold nature of Hua shi and protect the middle jiao, while Hua shi can prevent stasis due to the sweet flavor of Gan cao. As a pair, they clear heat, eliminate summer-heat, disinhibit urination without damaging the middle burner, and free strangury. For such indications as:
– 1. Fever, vexation, agitation, thirst, vomiting, diarrhea, and dysuria due to attack of summer-heat with internal and external heat. (Liu Yi San)
– 2. Turbid strangury.
– 3. Stone and/or sand strangury.

Dose: 9-18g

Jin Qian Cao – Lysimachia* – “Gold Money Herb”

Nature: sweet, bland, neutral

Enters: Kidney, Bladder, Liver, Gallbladder

Actions: Dissolves stones and discharges them; eliminates dampness; clears damp-heat from the liver and gallbladder, relieves jaundice; eliminates toxicity; relieves swelling; drains dampness and heat by promoting urination; unblocks painful urinary dysfunction.

Indications:
• Damp-heat and/or bladder stones, kidney stones, or gall stones: painful urination.
• Liver/gallbladder damp-heat: jaundice and/or red, swollen eyes.
• Topical and/or internal: for carbuncles, boils, snake bite, abscess, traumatic injury.
• Very effective for acute mastitis.
• Often used alone as an infusion for stones.
*A diverse array of herbs that have similar functions are used as Jin qian cao. Besides Lysimachia christinae, these include:
Desdemodium styracifolium – known as Guang Jin Qian Cao, since it comes from Guangdong.
Glechoma longituba – (Ground Ivy) known as Lian Qian Cao, “Linking Gold Money Herb.”
Dichondra repens – known as Xi Jin Qian Cao, as it comes from Jiangxi.
Hydrocotyle sibthorpiodes – known as Xiao Jin Qian Cao, “Little Gold Money Herb.”
Hsu: Helps dissolve and excrete urinary calculi, stimulates bile production.
DY: Very effective in cases of biliary or renal lithiasis and may be used alone at a dose of 200-250g. Even when combined with other herbs, it should still be prescribed in relatively high doses of 50-150g daily.
• With Hai jin sha for mutual enhancement, to strongly clear heat and eliminate dampness, disinhibit urination, free strangury, and expel stones. See Hai jin sha in this category for specific indications and notes.
SD: May help antidote mercury and lead poisoning.

Dose: 15-60g (or much more for stones)

Mu Tong – Akebia* – “Open-ended Wood”

Nature: bitter, cold

Enters: Bladder, Heart, Small Intestine

Actions: Drains dampness and heat by promoting urination; clears heart heat – conducts heart heat out through the small intestine and the bladder to the urine; promotes lactation (by opening the channels); unblocks the blood vessels, promotes blood circulation.

Indications:
• Heart fire pouring downward to the small intestine: irritability, mouth and tongue sores, restlessness, scanty, concentrated urine.
• Bladder damp-heat: scanty, yellow, painful urination, edema, leg qi.
• Damp-heat obstruction: Bi syndrome, joint pain, stiffness, amenorrhea.
• Insufficient lactation after childbirth.
• Regarding its ability to promote lactation, this refers to an ability to enhance the flow of milk, but not to produce it. In cases of insufficient lactation due to blood deficiency (milk is a product of the blood), you must nourish blood.
• This herb can easily injure the body fluids/Yin.
• Doctrine of signatures: this herb’s highly porous form – a dense vascular network like pipes – is suggestive of its ability to conduct fluids (milk, urine).
* Though Akebia species were most commonly listed in classical pharmacopeias as this herb, this plant is rarely used in China today. Instead, Aristolochia manshuriensis and Clematis armandi or C. montana are used. Given the recent warnings about aristolochic acid as a possible cause of kidney damage, it is advisable to choose a reputable supplier to ensure you do not get Aristolochia.
MLT: For urinary dysfunction associated with or caused by irritability and emotional stress.

Dose: 3-9g

Ba Yue Zha: Akebia fruit – “Eighth-Month Sticker”
• Bitter, neutral; liver, stomach.
• Frees the liver Qi; dissipates clumps; promotes urination.
• Used mostly for hypochondriac or hernial pain, most commonly associated with liver/spleen disharmony.
• Scrofula and other nodular disorders.
• Urinary difficulty and stony, painful urination.
• Recent use: for tumors of the breasts and digestive tract.

Dose: 6-12g

Qu Mai – Dianthus – Pinks

Nature: bitter, cold

Enters: Bladder, Heart, Small Intestine

Actions: Clears damp-heat, promotes urination, unblocks painful urinary dysfunction; breaks up blood stasis; unblocks the bowels.

Indications:
• Any type of painful urinary dysfunction, especially when bloody.
• Blood stasis: amenorrhea (an auxiliary herb).
• Constipation.
• In cases of damp-heat induced painful urinary dysfunction, this herb is most appropriate when heat is predominant.
• The flowers are the most diuretic part of the plant. (Not potassium sparing: in animal experiments, the herb had a more significant effect on potassium excretion than on that of sodium.)
MLT: Strong diuretic, also stimulates intestinal peristalsis.
Hsu: Increases intestinal peristalsis, hypotensive, anthelmintic.

Dose: 6-12g (up to 24g)

Shi Wei – Pyrossia leaf – “Stone Reed”

Nature: bitter, sweet, slightly cold

Enters: Lung, Bladder

Actions: Clears the Lungs, expels phlegm, stops coughing; drains dampness and heat by promoting urination; clears heat, stops bleeding.

Indications:
• Damp-heat or stones in the lower Jiao: hot, stony, or painful urination with blood.
• Retention of harmful body fluid: edema.
• Heat in the blood: hematemesis, uterine bleeding, hematuria.
• Heat in the Lungs: cough, difficulty breathing, wheezing.
Hsu: Antibacterial; strong antitussive, expectorant, and antispasmodic.

Dose: 3-9g (up to 30g)

Tong Cao – Tetrapanax – Rice Paper Pith – “Unblocking Herb”

Nature: sweet, bland, slightly cold

Enters: Stomach, Lung

Actions: Clears heat and mildly drains dampness by promoting urination; promotes lactation; conducts Lung heat out through the bladder.

Indications:
• Damp-heat or damp warm-febrile disease affecting the lower Jiao: scanty, painful urination. Usually prescribed as an assistant or envoy.
• Insufficient or absent lactation.

Dose: 3-6g

Yi Yi Ren – Coix seed – Job’s tears

Nature: sweet, bland, slightly cold

Enters: Spleen, Stomach, Lung, Kidney

Actions: Drains dampness and harmful body fluid by promoting urination; expels wind-dampness, eliminates dampness from the channels; mildly tonifies spleen Qi, stops diarrhea; clears heat; drains pus; clears the eyes; expels phlegm, stops coughing.

Indications:
• Retention of dampness and harmful body fluid, especially when due to spleen Qi deficiency: scanty urination, edema, diarrhea, damp leg qi.
• Damp-heat: any damp-heat disorder at any level characterized by a greasy tongue coating and digestive problems.
• Wind-damp: Bi syndrome with tendon spasms. Especially effective for increasing joint mobility and reducing spasms in chronic cases.
• Lung or large intestine heat: Lung abscess or appendicitis
• Soft, pustulated carbuncles.
• Lung phlegm-heat, cough.
• Can also be used for problems due to liver or kidney deficiency or liver channel heat.
• Despite its slightly cold nature, it does not hurt the stomach, and despite its sweet flavor, it does not block the Qi
• Weaker than Fu ling at tonifying the spleen. Milder at draining than Ze xie.
• Liu: Best herb for damp-heat with spleen Qi deficiency.
• For chronic spleen Qi deficiency with dampness, can be cooked into a porridge with rice, Da zao, Bai bian dou, etc.
• It is reported that Yi yi ren has an inhibitory effect on the growth of cancer cells.
• Should be cooked at least 30 minutes.
• Dry-fry to tonify the spleen.
• Note: although some sources refer to this herb as “pearl barley,” this is not barley and does not contain gluten.
Li: Good for generalized body aches due to damp accumulation.
MLT: Regulates fluid metabolism – drains dampness while it moistens the skin.
• Also for warts and fatty tumors, rheumatoid arthritis.
• Research shows anti-cancer properties.
Hsu: Hypoglycemiant.
Eric Brand: Yi Yi Ren, by its ability to clear damp-heat and expel pus, is also often used for acne and to generally enhance the treatment of skin conditions. For this purpose it can be liberally added to soups and congees.  In Japanese Kampo, it is also added to Gui Zhi Fu Ling Wan to make an empirical formula for stubborn cases of acne.

Dose: 9-30g

Yin Chen Hao – Capillaris – Artemisia capillaris (or A. scoparia)

Nature: bitter, slightly cold

Enters: Spleen, Stomach, Liver, Gallbladder

Actions: Drains dampness and mildly clears heat to relieve jaundice; descends stomach and gallbladder Qi; frees the liver Qi; helps the liver Qi and spleen Qi lift; clears heat and releases the exterior.

Indications:
• Damp-heat or damp-cold in the liver and gallbladder: jaundice. Can be used alone for this. For damp-cold jaundice (greyer/duller color), add herbs such as Fu zi, Gan jiang.
• Heat patterns: intermittent fever and chills, bitter taste in the mouth, stifling sensation in the chest, flank pain, dizziness, nausea, loss of appetite.
• Also and important herb for hepatitis, especially icteric, including acute hepatitis B. In one study, subjects were effectively treated with administration of 30-45g of Yin chen hao 3 times a day.
Liu: Vents heat from Ying/Xue to Qi level, good for lurking heat.
• Promotes bile secretion.
• Lowers blood pressure.
• This herb is picked in early spring and contains the energy of the wood element.
• Bensky/Gamble: Compared to Chai hu, Yin chen hao is less drying and is “softer.” It is especially useful when a patient with a Yin deficient or excessive fire constitution needs the heat-clearing action of Chai hu but is unable to tolerate its dry nature.
• In disorders of the anatomical liver, this herb may be more effective when combined with Da huang and Zhi zi.
Hsu: Antipyretic; lowers serum cholesterol and β-lipoprotein; antibacterial, antiviral, antifungal.

Dose: 9-15g (up to 30g in very severe cases)

Yu Mi Xu Cornsilk – “Jade Rice Whiskers”

Nature: sweet, neutral

Enters: Bladder, Gallbladder, Liver

Actions: Promotes urination; benefits the gallbladder, alleviates jaundice.

Indications:
• Hot or stony, painful urinary dysfunction or edema.
• Can be used for either yin- or yang-type jaundice (depending on the other herbs with which it is combined).
• Wasting and thirsting disorder.
• For many disorders of the biliary system. Cholagogue.
• Relatively weak and safe diuretic.
• Reduces clotting time and increases prothrombin concentration in the blood.
• Intravenous administration of the infusion has been used for its marked hypotensive effect (which is not seen with oral administration, even over long periods of time).
K&R: Diuretic (volumetric, azoturic, uricosuric, natriuric), choleretic, cholagogue, TSH inhibitor, hypocholesterolemiant, hypoglycemiant.
• Earth excess and deficiency, water excess and deficiency.
• Extracts are diuretic and are used to relieve the pain of rheumatism and gout; as a diuretic, it treats: nephritis, cardiac insufficiency, edema
• Also for obesity, high cholesterol, arterial hypertension.
• Germ oil: inhibits development of arterial plaque, strong influence on pancreatic-duodenal junction, and is used to treat hepatitis and cholecystitis.
Hall: Mucilaginous, soothing demulcent. Acts especially on the urinary tract and kidneys.
• For cystitis, burning on intercourse.
MLT: Helps dispel and expel stones.
PCBDP: Also useful for prostatitis.
Hsu: Hypotensive, hypoglycemiant, cholagogue, decreases bile viscosity – good for chronic cholecystitis and difficulty in bile secretion due to cholangitis.
• Hemostatic – increases platelet count and prothrombin.

Dose: 15-30g

Ze Xie – Alisma rhizome – Water Plantain – “Marsh Drain”

Nature: sweet, bland, cool

Enters: Kidney, Bladder

Actions: Drains dampness and harmful body fluid by promoting urination; clears (excess and deficient) heat, including kidney fire.

Indications:
• Retention of dampness and harmful body fluid, especially damp-heat in the lower Jiao: scanty urination, urinary difficulty, edema, diarrhea, leukorrhea, dizziness.
• Kidney Yin deficiency heat: dizziness, tinnitus.
• Classically: for wasting and thirsting disorder.
• In terms of strength at draining dampness, Ze xie is second to Zhu ling in this category.
• Doctrine of signatures: some say this herb resembles a kidney.
Ze xie’s diuretic strength varies according to when it is harvested. Winter yields the most potent herb, and spring the least. The salt-prepared form is not an effective diuretic. Ze xie’s diuretic effect causes an increase in the excretion of sodium and urea. The herb has a high concentration of potassium, which may be a factor in its diuretic effect.
Ze xie seems to lower serum glucose.
• Compared to other herbs which promote urination, Ze xie has less of a tendency to damage the Yin.
Li: Does not damage the Yin.
Liu: Must be combined with Shu di huang to avoid damage to the Yin.
Li Dong Yuan: Leads Yang Qi back down to its lower source.
Jin: Good for draining fluid from the ear.
MLT: Make into congee (stir fry the herb, powder it, add it to rice) and take for inhibited urination, edema, leukorrhea, obesity, high cholesterol, hypertension, chronic liver disease.
DY: Drains fire from the liver, kidney, and bladder channels; clears damp-heat from the lower burner; clears heat from the Qi division.
With Huang bai to clear and drain fire due to Yin deficiency, and clear and eliminate dampness and heat. For indications such as:
– 1. Steaming bones, night sweats, and seminal emission due to deficiency fire. (Zhi Bai Di Huang Wan) Both herbs should be salt mix-fried.
– 2. Inhibited urination and pricking, painful urination due to damp-heat in the lower burner. (Salt mix-fried Huang bai and either unprepared or salt mix-fried Ze xie should be used.)
Hsu: Hypotensive, hypoglycemiant, antibiotic (TB).

Dose: 6-15g

Notes on This Category

• Since the dispersing effect of some of the herbs in this category is dependent on their volatile oils, they are often decocted only for a short time (or are infused only) since heat causes volatization of these oils. Toasting them thus tends to moderate their effect.
• These herbs should be used with caution in cases of Yin deficiency.
• Herbs in this category are frequently combined with:
A. Herbs that clear heat when there is heat associated.
B. Herbs that warm the interior when there is cold associated.
C. Herbs that tonify the spleen when there is spleen Qi deficiency.
D. Herbs that promote Qi circulation, since moving Qi can help in the elimination of dampness.

Bai Dou Kou – Cardamom fruit – Cluster – Amomum cardamomum or A. kravanh (syn: Elettaria cardamomum) “White Cardamom”

Nature: acrid, warm

Enters: Spleen, Stomach, Lung

Actions: Warms the middle Jiao; promotes Qi circulation, transforms stagnation; stops vomiting; transforms dampness; descends rebellious Qi.

Indications:
• Dampness and Qi stagnation in the spleen and stomach: distending pain in the epigastrium and abdomen, poor appetite, nausea, vomiting, fullness in the chest.
• Stomach cold, or cold from deficiency of the spleen and stomach: vomiting.
• Damp warm-febrile disease: stifling sensation in the chest, lack of appetite, very greasy tongue coat.
• Not too warm (cooler than Sha ren) alright for use with damp-heat.
• Smash before using.
• When decocting, add near the end.
MLT: Sha ren is better for the middle and lower Jiao, while Bai dou kou is better for the middle and upper Jiao.
Hsu: Stomachic, antiemetic, stimulates GI secretions and intestinal peristalsis, inhibits abnormal fermentation in intestines, dispels accumulated air in GI tract, prevents vomiting.
Yoga: Ela: pungent, sweet/heating/pungent; V, K-; P+ (in excess)
• Affects digestive, respiratory, circulatory, and nervous systems.
• Stimulant, expectorant, carminative, stomachic, diaphoretic.
• Awakens the spleen, kindles Agni, removes Kapha from the stomach and Lungs.
• Stops vomiting, belching, and acid regurgitation. Good, safe digestive stimulant.
• Stimulates the mind and heart, and gives clarity and joy.
Sattvic. Opens and soothes the flow of the Pranas.
• For colds, cough, bronchitis, asthma, hoarseness, loss of taste, poor absorption, indigestion.
• Nervous digestive upset in children or for high Vata (good with fennel for this).
• Add this herb to milk to neutralize milk’s mucus-forming properties.
• Detoxifies the caffeine in coffee.
• Stimulates absorption from the small intestine.

Dose: 3-6g in decoction, or, preferably, 1.5-4.5g directly as powder.

Cang Zhu – Red Atractylodes rhizome (also known as Black Atractylodes)

Nature: acrid, bitter, warm

Enters: Spleen, Stomach

Actions: Strongly dries dampness and strengthens/activates the spleen; eliminates wind- dampness (and cold); eliminates dampness in the lower Jiao; induces sweating, releases exterior syndromes; improves vision.

Indications:
• Accumulation of dampness in the middle Jiao: distention in the epigastrium and abdomen, poor appetite, diarrhea, epigastric distention and pressure, fatigue, nausea, vomiting, thick and greasy tongue coat.
• Wind-cold-dampness: Bi syndrome with swollen knees and feet, pain in the extremities.
• Wind-damp-cold EPI: headache, body aches, absence of sweating, and/or oozing yin sores.
• Damp skin disease: acute eczema, vitiligo.
• Night blindness or poor vision with a rough sensation in the eyes.
• Damp-heat pouring downward: leg qi, vaginal discharge, swollen, sore joints (use with heat-clearing herbs).
• Increases IgA, IgG, IgM in nose to enhance local immunity.
• Mix with Bai zhi, grind into powder, and hang over the chest to prevent EPIs. Also burn these two herbs as the weather gets warm – on the new moon about early May – to enhance immunity.
Li: 1/3 the strength of Bai zhu to tonify, 3 times the strength to resolve damp. Quite warm and very drying.
DY: One of the most drying substances in the whole Chinese pharmacopeia.
• Upbears the clear and downbears the turbid.
• Stops diarrhea.
• Can be used for damp-heat when combined with bitter, cold herbs.
Cang zhu is incompatible with black carp, peaches, plums, and Chinese cabbage.
• With Huang bai for mutual reinforcement, to clear heat, dry dampness, disperse swelling, and stop pain. For indications such as:
– 1. Wilting of the lower extremities with pain in the sinews and bones due to damp-heat pouring downward. (Er Miao San) Use salt mix-fried Huang bai.
– 2. Abnormal vaginal discharge, external vaginal itching, and cloudy, scanty urination due to damp-heat. (Use Cang zhu which has been stir-fried until scorched.)
– 3. Red, swollen, hot, painful joints due to wind, damp, heat impediment. (Cang Zhu San)
MLT: Possesses no significant diuretic properties despite its strong drying action (does increase secretion of urinary salts).
• Can dramatically lower blood sugar for some kinds of diabetes.
Hsu: Stomachic, diuretic, diaphoretic, tranquilizer, hypoglycemiant, tonic.

Dose: 4.5-9g

Cao Dou Kou – Alpinia katsumadai seed – Katsumada’s Galangal seed – “Grass Cardamom”

Nature: acrid, very warm

Enters: Spleen, Stomach

Actions: Warms the middle Jiao; promotes Qi circulation; dries dampness.

Indications:
• Cold and dampness in the spleen and stomach: fullness, distention, and pain in the epigastrium and abdomen, accompanied by vomiting, diarrhea.
• This is the warmest herb in the category.
Cao dou kou is much warmer and much drier than Sha ren. For this reason, it is not usually a first choice. It is appropriate only for cold-dampness.
• When decocting, do not cook long.

Dose: 1.5-6g

Cao Guo – Tsaoko fruit – Amomum tsaoko – “Grass Fruit”

Nature: acrid, warm

Enters: Spleen, Stomach

Actions: Warms the middle Jiao; strongly dries dampness; disperses cold; treats malaria; dissolves stagnation and distention.

Indications:
• Cold and dampness in the spleen and stomach: distending pain and fullness in the epigastrium and abdomen, vomiting, diarrhea, very greasy tongue coat.
• Malaria: especially due to excess damp-cold or turbid dampness.
• Food stagnation: indigestion, especially due to meat.
• Cold from spleen and stomach deficiency: focal distention, nausea.
• Roasting the herb reduces the possible side effect of vomiting.
Dose: 1.5-6g

Hou Po – Magnolia Bark

Nature: bitter, acrid, warm

Enters: Spleen, Stomach, Lung, Large Intestine

Actions: Promotes Qi circulation; transforms dampness, resolves stagnation; relieves asthma; descends the Qi of the Lungs, stomach, and large intestine (directs upward-rebelling Qi downward); warms and transforms phlegm.

• Accumulation of damp or food causing stagnation of Qi in the middle Jiao: distention and fullness of epigastrium, abdomen, and chest, loss of appetite, vomiting, diarrhea. This is a key herb for eliminating distention and fullness.
• Lung phlegm: wheezing, cough with difficult breathing, stifling sensation in the chest, copious sputum.
• Most effective herb to promote Qi circulation in this category.
• Binds to GABA receptors, produces calming effect.
• Reduces allergic and asthmatic reactions.
• Counters effects of excessive cortisol, beneficial for insomnia and anxiety with high cortisol.
MLT: Gently stimulates intestinal peristalsis – for damp stagnation with either diarrhea or constipation.
• Antimicrobial (though significantly weaker than the yellow herbs/berberine).
PCBDP: Stimulant, tonic, aromatic, diaphoretic, anti-inflammatory.
Hsu: Antispasmodic, antibacterial, stomachic.
Weil: An Italian study published in February, 2011, compared a magnolia bark extract to soy isoflavones for treatment of anxiety, irritability and insomnia in menopausal women. The researchers found that the isoflavones effectively lessened the severity of classic menopausal symptoms, including hot flashes, while magnolia bark eased the participants’ anxiety. Dr. Low Dog noted that an earlier study from Italy found that magnolia bark extract combined with magnesium improved sleep, mood, depression and anxiety in menopausal women.
Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model: There is growing evidence that neuroinflammation is closely linked to depression. Honokiol, a biologically active substance extracted from Magnolia officinalis, which is widely used in traditional Chinese medicine, has been shown to exert significant anti-inflammatory effects and improve depression-like behavior caused by inflammation….
Honokiol: A Review of Its Anticancer Potential and Mechanisms
Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents
Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders
Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent: [ANTIOXIDANTS & REDOX SIGNALING. Volume 11, Number 5, 2009] Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares certain biologic properties. Recently, honokiol has been found to have antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, without appreciable toxicity. These findings have increased interest in bringing honokiol to the clinic as a novel chemotherapeutic agent. In addition, mechanistic studies have tried to find the mechanism(s) of action of honokiol, for two major reasons. First, knowledge of the mechanisms of action may assist development of novel synthetic analogues. Second, mechanistic actions of honokiol may lead to rational combinations with conventional chemotherapy or radiation for enhanced response to systemic cancers. In this review, we describe the findings that honokiol has two major mechanisms of action. First, it blocks signaling in tumors with defective p53 function and activated ras by directly blocking the activation of phospholipase D by activated ras. Second, honokiol induces cyclophilin D, thus potentiating the mitochondrial permeability transition pore, and causing death in cells with wild-type p53. Knowledge of the dual activities of honokiol can assist with the development of honokiol derivatives and the design of clinical trials that will maximize the potential benefit of honokiol in the patient setting.
Wiki: Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, antidepressant, antiemetic, and antibacterial. While early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable antitumorigenic and neurotrophic compound.
Anti-tumorigenic activities:
Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma[1] and colon cancer cell lines.[2][3][4][5] Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol regulates the nuclear factor kappa B (NF-?B) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), MCL1, and cyclooxygenase 2 (COX-2), all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol’s pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.
Neurotrophic activity:
Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.[6] Honokiol is a weak cannabinoid CB2 receptor ligand but the naturally occurring derivative 4-O-methylhonokiol was shown to be a potent and selective cannabinoid CB2 receptor inverse agonist and to possess antiosteoclastic effects.[7]
Anti-thrombotic activity:
Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotein injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol’s anti-thrombotic activity.[8]
Examine.com presents a pretty comprehensive review of existing scientific data on this herb (click here).

Dose: 3-9g

Hou Po Hua: flower (different species than Xin yi hua, also magnolia flower)
• Acrid, warm, aromatic.
• Similar to, but weaker than the bark.
• Focuses more on the upper and middle Jiao, and regulates liver Qi.
• For a stifling sensation in the chest.
• Stomach ache due to liver/stomach disharmony.
Dose: 3-6g

Huo Xiang – Patchouli – Agastache or Pogostemon

Nature: acrid, slightly warm

Enters: Spleen, Stomach, Lung

Actions: Transforms dampness; releases the exterior, clears summer heat (and wind-cold); harmonizes the middle Jiao, stops vomiting; awakens the spleen.

Indications:

• Damp accumulation in the middle Jiao: vomiting, distention in the epigastrium and abdomen, poor appetite, nausea, lethargy, weakness, white, moist tongue coat.
• Summer heat with dampness: fever, aversion to cold, headache, distended epigastrium, diarrhea, nausea, vomiting.
• Wind-cold EPI.
• Similar to Zi su ye, though Huo xiang is stronger at circulating Qi and Zi su ye is stronger at eliminating wind-cold. Zi su ye has a stronger focus on the Lungs than Huo xiang.
Li: Often adds to formulas for patients with digestive weakness, or when using difficult-to-digest herbs, (also in combination with Pei lan) to keep herbs from causing stagnation or upsetting or damaging the digestion.
Hsu: Antiemetic, antidiarrheal, tranquilizes GI nerves, antifungal, antipyretic, stomachic.
DY: Moves the Qi; strongly clears summer-heat (mainly summer-heat-dampness).
• The leaf (Huo xiang ye) is more powerful than the stem at draining the exterior. The stem (Huo xiang geng) is better for harmonizing the stomach and stopping vomiting.
• More powerful than Pei lan at resolving the exterior and eliminating summer-heat as well as for stopping vomiting.
• With Pei lan to effectively transform dampness and turbidity, harmonize the middle burner, stop vomiting, eliminate summer-heat (and dampness), and stop diarrhea. For indications such as:
– 1. Vertigo, head distention, fever with or without perspiration, chest oppression, epigastric distention, nausea, vomiting, abdominal pain, and diarrhea due to external attack of summer-heat-dampness.
– 2. Spleen pure heat. This refers to a rising upward of turbid Qi towards the mouth due to spleen heat generated by an excess of fatty and sweet foods. It is accompanied by a sticky, thick feeling in the mouth, a sugary taste in the mouth, abundant salivation, thick, slimy tongue coat, and a slippery pulse.
– This combination is very effective for its treatment of bad breath or a thick, sticky feeling in the mouth with a sugary taste due to turbid dampness accumulation or turbid dampness transforming into heat.

Dose: 4.5-9g

Pei Lan – Eupatorium (Eupatorium fortunei, E. japonicum) – “Ornamental Orchid”

Nature: acrid, neutral

Enters: Spleen, Stomach

Actions: Transforms dampness; clears summer-heat; releases the exterior and transforms turbidity.

• Damp accumulation in the middle Jiao: distention in the epigastrium and abdomen, poor appetite, nausea, weakness, lethargy, vomiting, stifling sensation in the chest, white, moist tongue coat.
• Summer-heat with dampness: fever, aversion to cold, headache, distended epigastrium, diarrhea, nausea, vomiting.
• Spleen damp-heat: sweet, sticky taste in the mouth, copious saliva, foul breath.
• Early-stage of damp warm-febrile diseases.
• Topical: as powder on a sweaty, sour, smelly scalp (the synonym Xing tou cao relates to this use).
• Does not lead to dryness.
• Much weaker than Huo xiang at releasing exterior syndromes.
Hsu: Antiviral, antipyretic, stomachic, diuretic.
DY: With Huo xiang to effectively transform dampness and turbidity, harmonize the middle burner, stop vomiting, eliminate summer-heat (and dampness), and stop diarrhea. For specific indications and notes, see Huo xiang in this category.
Pei lan is more powerful than Huo xiang for transforming turbid dampness. In addition, it clears dampness which has transformed into heat and treats spleen pure heat. (“Spleen pure heat” refers to a rising upward of turbid Qi towards the mouth due to spleen heat generated by an excess of fatty and sweet foods. It is accompanied by a sticky, thick feeling in the mouth, a sugary taste in the mouth, abundant salivation, thick, slimy tongue coat, and a slippery pulse.)

Dose: 4.5-9g

Notes on This Category

• Use caution with cases of Yin or blood deficiency, since these herbs tend to be acrid, warm, and drying.
• Since the dispersing effect of some of the more aromatic herbs in this category is dependent on their volatile oils, they are often decocted only for a short time (or are infused only).
• Herbs in this category are frequently combined with:
A. Herbs that eliminate wind and relieve exterior syndromes when the disease is located on the body surface or in the upper part of the body.
B. Herbs that promote blood circulation and remove obstruction from the channels and collaterals when there is associated blood stasis.
C. Herbs that warm the channels when there is cold associated.
D. Herbs that tonify Qi and nourish blood when there is Qi and/or blood deficiency.
E. Herbs that tonify the kidneys and liver when there is deficiency of these organs.

Bai Hua She – Agkistrodon Snake or Bungarus Snake – “White-Patterned Snake”

Nature: sweet, salty, warm

Enters: Liver, Spleen

Actions: Eliminates internal and external wind; activates the collaterals; relieves convulsions; powerfully unblocks the channels.

Indications:
• Wind-related disorders:
• Wind-damp: Bi syndrome, numbness and weakness of the limbs, cramping of the sinews.
• Wind-stroke: facial paralysis, hemiplegia.
• Wind in the skin: itching, tinea, numbness of the skin, any kind of rash.
• Liver wind stirring: infant convulsions and tetanus.
• Wind in the sinews: spasms, tremors, seizures.
• Doctrine of signatures: the movement and pervasiveness of a snake: can go anywhere, deep or superficial, even to the bones, to eliminate wind.
Hsu: Tranquilizer, hypotensive.

Dose: 3-10g (1-1.5g directly as powder)

Du Huo – Angelica pubescens root** – “Self-Reliant Existence”

Nature: acrid, bitter, warm

Enters: Liver, Kidney, Bladder

Actions: Eliminates wind-dampness, alleviates pain; releases the exterior, disperses wind-cold-dampness.

Indications:
• Wind-damp: Bi syndrome, body pain – especially lower back and legs – can be used for both acute and chronic conditions. Gout.
• Exterior wind-cold together with dampness.
Shaoyin headache radiating to the teeth.
• A small dose (3-6g) can lift spleen Yang and treat internal dampness.
• Tranquilizing effect.
• **As with numerous Chinese herbs, several different species are used as this herb. In some parts of China A. dahurica (Bai zhi) is used, and species of the Heraclelum and Aralia genera are also used.
• May cause skin photosensitivity with topical application.
• It is said that when the wind blows, this plant is still.
• Compared to Qiang huo, Du huo is more for the lower body (while Qiang huo is stronger & more for the upper body), Du huo is milder at eliminating exterior syndromes but is more effective at eliminating dampness than Qiang huo.
MLT: Promotes Qi and blood circulation, similar to Western (A. archangelica) species.
Hsu: Sedative, analgesic, antiarthritic, hypotensive.
DY: Moderate in action; treats hidden wind or wind which is more internal and fixed; tropism: the lower part of the body, lumbar area, knees, legs, feet, and Shaoyin.
• With Qiang huo to dispel wind, cold, dampness, and treat Bi over the whole body. For indications such as:
– 1. Moving rheumatic pains all over the body. (Juan Bi Tang)
– 2. Common cold with fever, back pain, and joint pain due to wind, cold, and dampness. (Qiang Huo Sheng Shi Tang)
– 3. Joint running wind due to wind, cold, and dampness penetrating the channels and network vessels. Li jie feng or joint running wind refers to acute arthralgia which is severe and movable with loss of joint mobility, swelling, and intense joint pain which is worse at night. This affection can transform itself into heat and then cause redness, pain, swelling, and heat.

Dose: 3-15g

Fang Ji – (Han Fang Ji) – Stephania root

Nature: bitter, acrid, cold

Enters: Bladder, Kidney, Spleen

Actions: Eliminates wind-dampness; drains dampness by promoting urination; relieves pain; reduces edema.

Indications:
• Wind-damp-heat: Bi syndrome, fever, red, swollen, hot, painful joints.
• Damp accumulation in the lower Jiao: edema (facial, legs, or systemic, but especially good for the lower body), ascites, gurgling sounds in the intestines, abdominal distention, damp leg qi.
• Anti-inflammatory.
• Analgesic: 1/4 the strength of Yan hu suo, 1/1000 the potency of morphine, less effect in very high doses.
• Treats dampness in two ways (eliminates from the surface, promotes urination).
• Lowers BP by vasodilation.
• Antiparasitic: against Entamoeba histolytica (stronger than berberine).
DY: Quickens the channels; opens the pores of the skin; opens the nice orifices; disperses swelling; drains evil Qi.
• With Huang qi to simultaneously drain and supplement, to support the correct Qi and drain evil Qi at the same time, to regulate the upbearing and downbearing of the Qi mechanism and strongly promote diuresis. For the following indications, the combination is found in Fang Ji Huang Qi Tang:
– 1. Edema due to wind-water with fever, fear of wind, edema predominantly in the upper body and face, joint pain, scanty urination, and a floating pulse. If wind attacks the exterior and blocks the Lung Qi, this causes a disturbance in the Lungs’ diffusing and downbearing function. Therefore, because the water passageways are not regulated, dampness is not moved downward. Thus, there is accumulation of dampness in the upper body and edema appears.
– 2. Rheumatic pain due to damp Bi with heavy limbs, joint numbness, and sometimes swollen joints.
– 3. Chronic nephritis and cardiac disease with edema due to Qi deficiency and accumulation of dampness.
Han fang ji is usually used for edema and accumulation of damp-heat in the lower half of the body. When combined with Huang qi, Han fang ji can then treat edema in the upper half of the body and of the wind type.

Dose: 3-9g

Guang Fang Ji (Mu Fang Ji) – Aristolochia fangchi is also referred to simply as Fang Ji. It contains aristolochic acid, which has been associated with kidney damage when misused (though no historical sources of Chinese medicine recorded any detrimental effects when properly used). Its use is prohibited by the FDA in the United States.

Hai Feng Teng – Kadsura stem – Piper futokadsura – “Sea Wind Vine”

Nature: acrid, bitter, slightly warm

Enters: Liver

Actions: Eliminates wind-dampness; dispels obstructions from the channels and collaterals; disperses cold, relieves pain.

Indications:
• Wind-damp: Bi syndrome with limited movement of joints, spasm of tendons, stiff joints, lower back pain, cramping of the muscles and sinews, sore knees.
• Pain due to trauma.
• Cold invading the spleen and stomach: epigastric and abdominal pain and diarrhea.
• Can be used for pain in either the upper or lower body.
• Some anti-neoplastic effects.
Hsu: Analgesic.

Dose: 6-15g

Hai Tong Pi – Erythrina bark – Coral-bean bark

Nature: bitter, acrid, neutral

Enters: Liver, Spleen, Kidney

Actions: Eliminates wind-dampness; dispels obstruction from channels and collaterals; promotes urination, reduces edema; treats itching skin lesions and toothaches.

Indications:
• Wind-damp (heat or cold): Bi syndrome with spasm of tendons (especially in the extremities), soreness of the lumbar region and knees.
• Dampness: superficial edema.
• Gout pain.
• Topical: itching skin lesions – scabies, etc.
• Gargle for toothache due to cavities.

Dose: 6-15g

Luo Shi Teng – Trachelospermum – Star Jasmine stem – “Collateral Stone Vine”

Nature: bitter, slightly cold

Enters: Heart, Liver

Actions: Cools the blood; relieves swelling; eliminates wind-dampness; unblocks the channels.

Indications:
• Wind-damp: Bi, spasm of tendons (especially suitable for wind-damp-heat).
• Heat in the blood: sore and swollen throat, carbuncles, red, hot, painful abscesses, toxic sores.
• Can be used for pain in either the upper or lower body.
• One component, Arctiin, is vasodilatory and lowers blood pressure.

Dose: 6-15g

Mu Gua – Chinese Quince – Chaenomelis fruit – “Wood Melon”

Nature: sour, warm

Enters: Liver, Stomach, Spleen

Actions: Relaxes the muscles and tendons; unblocks the channels; resolves dampness; harmonizes the stomach, adjusts the stomach and spleen; reduces food stagnation.

Indications:
• Spasm of calves due to diarrhea and vomiting (earth is weakened, [metal becomes weakened and cannot control wood] wood wind attacks earth’s muscles of the limbs), also abdominal pain, and edema due to leg qi.
• Wind-damp: Bi with spasm of tendons, painful obstruction of the extremities, especially with severe, cramping pain, and weakness in the lower back and lower extremities.
• Cannot treat exterior syndromes (does not expel wind or cold) – only resolves dampness, has a more interior effect.
• Very effective at relaxing the sinews.
• Especially suitable for treating pain in the lower body.
• Anti-inflammatory.
• Bensky/Gamble: excessive use can harm the teeth and bones.
Hsu: Antispasmodic, antibacterial, diuretic.

Dose: 4.5-12g

Qian Nian Jian – Homalomena rhizome – “Thousand Years of Health”

Nature: acrid, bitter, warm

Enters: Kidney, Liver

Actions: Dispels wind-dampness; strengthens the sinews and bones; promotes Qi circulation.

Indications:
• Wind-cold-damp: Bi syndrome with pain, spasms, or numbness whether perceived superficially (in the sinews) or deeply (in the bones).
• Weakness or softness in the sinews and bones: strong fortifying action.
• Traumatic injury: swelling, pain.
• Widely used in treating the elderly, both internally and as an external wash.

Dose: 4.5-9g

Qin Jiao – Gentiana macrophylla root

Nature: bitter, acrid, slightly cold

Enters: Stomach, Liver, Gallbladder

Actions: Relaxes the tendons and muscles; clears deficiency heat; eliminates wind-dampness; resolves dampness and relieves jaundice (damp-heat); moistens the intestines, unblocks the bowels.

Indications:
• Wind-damp: Bi with muscle and tendon spasms.
• Yin deficiency: tidal fever, steaming bone disorder.
• Dryness of the intestines: constipation.
• Damp-heat: jaundice, especially in acute cases and in infants.
• Only herb in this category that is not very drying. Use in formulas with other wind-damp herbs to counteract their drying qualities. Safe with Yin or blood deficiency.
• Antibacterial/fungal.
• May treat meningitis (used successfully by IM injection in study).
MLT: Anti-inflammatory.
Li: Can astringe sweats.
Hsu: Hypotensive, antiarthritic, analgesic, increases secretions from adrenal cortex.
DY: Guides to the spine and lumbar area.

Dose: 4.5-12g

Qing Feng Teng – Sinomenium

Nature: acrid, warm

Enters: Liver, Spleen

Actions: Promotes urination; eliminates toxicity; eliminates wind-dampness; dispels obstructions from the channels and collaterals.

Indications:
• Wind-damp: Bi syndrome with numbness of the skin.
• Accumulation of damp and harmful body fluids: edema.
• Heat-toxicity: carbuncles.
Wiki: Sinomenine or Cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.[1] However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine,[2] but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.[3]
Hsu: Analgesic (increases pain threshold), tranquilizer, antitussive (one constituent is similar to codeine), hypotensive – fast acting and long lasting, antiphlogistic.

Dose: 10-15g

Sang Zhi – Mulberry twig – Morus alba

Nature: bitter, neutral

Enters: Liver

Actions: Eliminates wind and dispels obstructions from the channels and collaterals; benefits the joints.

Indications:
• Wind-damp: Bi syndrome with spasm of the tendons – especially good for the upper extremities.
• Edema.
• May increase blastogenesis of lymphocytes.
• For lower body pain, can be combined with Du huo, Fang ji.

Dose: 10-30g

Wei Ling Xian Chinese Clematis root – “Awesome Spiritual Immortal” or “Temple’s Sacred Root” or “Strong and Very Effective”

Nature: acrid, salty, warm

Enters: Bladder

Actions: Eliminates wind-dampness, alleviates pain; dispels obstructions from the channels and collaterals; dissolves fish bones lodged in the throat; powerfully promotes Qi circulation at the body surface and in the channels; reduces phlegm and pathogenic water.

Indications:
• Wind-damp: Bi syndrome.
• Phlegm and pathogenic water: focal distention and accumulation in the middle Jiao.
• Useful in icteric infectious hepatitis.
• Fish bone lodged in the throat: use 15-30g, make a thick decoction with vinegar and brown sugar, swallow slowly (not for deeply lodged or very big bones).
• Can be used for pain in either the upper or lower body.
• While Liu translates Wei ling xian as “Strong, Very Effective,” Bensky/Gamble interprets it as “Awesome Spiritual Immortal,” and MLT says it translates as “Temple’s Sacred Root” and refers to the ancient story of an old nun who lived in the “Temple of Powerful Spirits” atop a mountain and used this herb often and with great success.
Hsu: Antibacterial, antifungal, hypotensive, analgesic, antidiuretic; “anti-sprain action.”

Dose: 6-12g

Wu Jia Pi – Eleutherococcus gracilistylus root bark (formerly known as Acanthopanax) – “Bark of Five Additions”

Nature: acrid, bitter, warm

Enters: Liver, Kidney

Actions: Strengthens the tendons and bones; eliminates wind-dampness; transforms dampness and reduces swelling.

Indications:
• Wind-damp: Bi syndrome with weakness in the lumbar region and knees (particularly when chronic deficiency of the liver and kidneys has led to weak or soft sinews and bones).
• Developmental delays in motor functions in children, especially retardation in walking.
• Urinary difficulty, edema, damp-cold leg qi.
• Good when the smooth flow of Qi and blood is obstructed.
• Especially effective for children and the elderly.
• The genera Acanthopanax and Eleutherococcus are one and the same (with the latter now being the preferred name), as authoritatively confirmed at the taxonomic symposium Biological Nomenclature in the 21st Century (University of MD, 1996). While Wu jia pi and Ci wu jia come from different species – E. gracilistylus and E. senticosus, respectively – E. gracilistylus seems to possess some (if not all) of the tonic properties attributed to E. senticosus (“Siberian Ginseng”). However, since it is the bark of the root that is used from the former (Wu jia pi) as opposed to the whole root, which is used in the case of Ci wu jia, Wu jia pi’s action is focused more on the surface (on dispersion of wind-dampness), than the interior (on tonification).
• A common but inferior substitute for this herb is Xiang jia pi – Periploca – which, although an effective herb at eliminating Wind-Dampness, is toxic and has little or no tonic properties. Unlike Wu jia pi, it is fragrant (slightly cinnamon-ish).
MLT: Often sold as a medicinal wine for neurasthenia, insomnia, excessive dreaming, forgetfulness, dizziness, poor appetite, palpitations, coronary heart disease, angina pectoris.
• Prolonged consumption can treat leukopenia from chemotherapy/ physiotherapy.
HF: A supplement with an anti-Gu nature, possessing acrid, toxin-resolving qualities, useful in Gu Zheng (Gu parasites) formulas.
BF: Good when wind-damp is accompanied by concomitant Qi and blood deficiency.
Hsu: Antiarthritic, antiphlogistic, analgesic, antipyretic, adaptogenic (increases the body’s non-specific resistance to disease and stress), hypotensive.

Dose: 4.5-15g

Notes on This Category

• Also consider, as appropriate: Ze xie, Zhi mu, Huang bai, Mu dan pi, Han lian cao, Tian men dong, etc.
• Bensky & Gamble, second edition, has a similar category – Herbs for Steaming Bone Disorder – which includes Di gu pi, Hu Huang lian, Mu dan pi, Qing hao, and Yin chai hu.
• Herbs in this category are commonly combined with:
A. Herbs that nourish Yin.
B. Herbs that strengthen the spleen and stomach, when there is deficiency of these organs.

Bai Wei – Cynanchum root – Swallowwort

Nature: bitter, salty, cold

Enters: Stomach, Liver, Lung, Kidney

Actions: Clears heat; cools the blood; promotes urination; eliminates toxicity.

Indications:
Ying or Xue level heat, or Yin deficiency, or blood deficiency (especially postpartum or after a febrile disease): fever.
• Heat in the blood: painful, hot or bloody urination. Especially before or after giving birth.
• Heat and toxicity: carbuncles, swollen, painful throat, snake bite, toxic sores. Can be used internally or applied topically for these indications.
• Some say this herb can conduct heat in the blood out of the vessels.
• Bensky/Gamble classifies Bei wei with herbs that clear heat and cool the blood.
MLT: Important in gynecological problems: postpartum inflammation, septicemia and/or accompanying restlessness.
• Urinary tract infection caused by Yin deficiency (use with Ren shen and Dan zhu ye).

Dose: 6-15g

Di Gu Pi – Lycium/Wolfberry root bark

Nature: sweet, bland, slightly cold

Enters: Lung, Kidney, Liver

Actions: Clears heat; cools the blood; drains Yin deficiency fire, including floating fire in the kidney channel; stops coughing.

Indications:
• Yin deficiency heat: tidal fever, night sweats, irritability, thirst, steaming bone disorder with sweating (if no sweating, use Mu dan pi).
• Lung heat (deficiency or excess): cough, asthma, wheezing.
• Kidney Yin deficiency fire: toothache.
• A strong decoction can be used as a dental analgesic. In one study of 11 patients with pulpitis, concentrated decoctions of Di gu pi effectively reduced the pain and inflammation in a mean time of one minute.
• Food retention and Yin deficiency: fever in children.
• Heat in the blood: hemoptysis, epistaxis, hematuria, hematemesis.
• Antipyretic. Less effect than aspirin.
• Lowers blood pressure. Especially for hypertension in classes I and II.
• Eczema and juvenile verruca plana: Di gu pi was shown to be beneficial when injected (no mention of the effect of oral administration).
• Malaria: in one study, Di gu pi and tea leaves given to malaria patients 2-3 hours before the onset of fever had a significant effect in 145 of 150 cases.
• Bensky/Gamble classifies this with herbs that clear heat and cool the blood.
Li: Can astringe sweats.
MLT: Topical: for fungal infection – use as a wash with Ye jiao teng, Ming fan, She chuang zi, Zi cao, Ku shen for genital itching, poison oak and ivy, and other rashes.
DY: Eliminates evils from the Yin division.
• With Sang bai pi to clear the Yin and Qi divisions, to effectively clear heat and drain fire from the Lungs, eliminate deficiency fire damaging the Lungs, stop cough, and calm asthma. For the following indications, the combination is found in Xie Bai San:
– 1. Cough and asthma with expectoration of yellow, sticky, and thick phlegm, fever and thirst due to Lung heat.
– 2. Cough accompanied by evening fever or low but persistent fever with skin which is warm to the touch due to deficiency heat damaging the Lungs.
– For the above indications, honey mix-fried Sang bai pi should be used. This combination can treat both full and deficiency heat. The Lungs are a delicate viscus and are easily damaged by heat. Full heat easily damages Lung Yin, causing both full and deficient heat simultaneously. This pair addresses this situation very well. In case of full heat, add Huang qin, Pi pa ye, and Zhe bei mu. In case of deficiency heat, add Zhi mu and Mai men dong.
Hsu: Hypotensive (vasodilator); hypoglycemiant; antibacterial; antipyretic.

Dose: 6-15g

Hu Huang Lian – Picrorhiza rhizome – “Barbarian Yellow Link”

Nature: bitter, cold

Enters: Heart, Liver, Stomach, Large Intestine

Actions: Clears damp-heat; clears Yin deficiency heat; reduces fever due to parasites; treats childhood nutritional impairment.

Indications:
• Large intestine damp-heat: diarrhea, dysentery, hemorrhoids. For these disorder, Hu huang lian is much weaker than Huang lian and should be used when Huang lian would be too strong for the patient.
• Digestive disorder with nutritional impairment in children: fever, abdominal distention, dysenteric diarrhea.
• Yin deficiency heat: tidal fever, night sweats, etc.
• Damp-heat: sores.
• Often used as a substitute for the more expensive Huang lian.
• Bensky/Gamble classifies this with herbs that clear heat and dry dampness.

Dose: 3-9g

BII: (P. kurroa) Extensive Ayurvedic use in the treatment of hepatic and respiratory disorders.
• Bronchial asthma: May prevent allergen-, histamine-, and PAF- induced bronchial obstruction.

Qing Hao – Artemisia annua or A. apiacea – Sweet Annie

Nature: bitter, acrid, cold

Enters: Liver, Gallbladder, Kidney

Actions: Clears summer-heat; cools the blood, stops bleeding; treats malaria; clears Yin deficiency heat; guides interior heat out to the exterior.

Indications:
• Summer-heat: fever, headache, dizziness, stifling sensation in the chest, with or without sweating.
• Yin deficiency, blood deficiency, or febrile disease: fever. Especially for unremitting fever or night fever and morning coolness with an absence of sweating.
• Yin deficiency: fever, hot sensation in the soles and palms.
• Heat in the blood: purpuric rashes, epistaxis.
• Malaria: alternating fever and chills (do not mistake for Shaoyang syndrome, do not use Xiao Chai Hu Tang). Liu: The extract of this herb – Qing Hao Su (essentially artemisinin) – is very strong at killing the malaria parasite (much stronger than Western medicines), and has no side effects. Useful for increasingly drug-resistant strains of malaria.
• Induces sweating.
• The leaves are the most potent part of the plant.
• Short cook.

• May be useful in the treatment of COVID-19:

Artemisia and Artemisia-based products for COVID-19 management: current state and future perspective

• Bensky/Gamble classifies with herbs to clear summer-heat.

HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.
BF: Anti-amoebic and anti-giardia effects.
• Very effective herb when there is deficiency heat above and damp-heat below.
MLT: This is the only heat clearing herb which is aromatic, bitter, and cold. It clears heat and dampness, while its aromatic quality protects the spleen from its bitter, cold nature. Though it is bitter, it will not injure the Yin. Though it is cold, it will not aggravate dampness. Its fragrant Qi is able to decongest turbidity. Being light and clear, it is able to rise upward and release evil through the surface.
• Useful for all four levels of Wenbing as either the primary or secondary herb in the formula.
• More neutral than Huang qin and Huang lian.

Dose: 3-10g (up to 24g for strong heat-clearing)

Notes on this Category

Herbs in this category are commonly combined with:
A. Herbs that strengthen the spleen and stomach, when there is deficiency of these organs.
B. Herbs that nourish Yin, when there is injury of body fluids by heat or the patient has pre-existing Yin deficiency.
C. Herbs that clear heat and cool the blood, when there is heat and toxicity in the blood.
D. Herbs that dry or drain dampness when there is associated dampness.

Bai Hua She She Cao – Hedyotis = Oldenlandia – “White-Patterned Snake’s Tongue Herb”

Nature: sweet, slightly bitter, cold

Enters: Stomach, Small Intestine, Large Intestine, Liver

Actions: Drains dampness, promotes urination; clears heat; eliminates toxicity; relieves stagnation of heat and toxicity; reduces abscesses.

Indications:
• Lower Jiao damp-heat: hot, painful urination. Also for damp-heat jaundice.
• Heat and toxicity: acne, carbuncles, boils, swollen, painful throat, intestinal abscess, appendicitis, sores, ulcerations, snake bite, ulcerative colitis. Used internally and topically.
• Cancer: stomach, esophagus, rectum (take 60g daily, long term, while monitoring digestion for cold damage). Usually combined with other herbs, such as Ban zhi lian.
• Strongly relieves fire-toxicity.

Dose: 15-60g

Bai Jiang Cao – Patrinia or Sonchus or Thlaspi

Nature: acrid, bitter, slightly cold

Enters: Stomach, Large Intestine, Liver

Actions: Clears heat; eliminates toxicity; relieves stagnation of heat and toxicity; drains pus; dispels blood stasis, relieves pain; calms the Shen.

Indications:
• Heat and toxicity: carbuncles, abscesses in organs, surface sores and swellings. Used internally and/or topically.
• Blood stasis (especially heat-induced): pain, especially in the chest and abdomen. Also for postpartum and postoperative pain.
• Prostatitis – drains pus out of the prostate.

• Shen disturbance with heat: anxiety and insomnia.
• Mumps: one study of over 200 cases showed Bai jiang cao to effectively treat mumps (used with Shi gao, internally plus applied topically as a paste), providing relief to 90% of cases within 24 hours.
MLT: Specific for colitis/intestinal heat. Anti-inflammatory.
Hsu: Antibacterial; protects the liver: stimulates regeneration of liver cells, prevents denaturalization.

Dose: 9-15g (to 30g)

Bai Lian – Ampelopsis

Nature: bitter, acrid, slightly cold

Enters: Heart, Stomach, Liver

Actions: Promotes tissue regeneration, heals wounds; clears heat; eliminates toxicity.

Indications:
Heat and toxicity: carbuncles, boils, burns
Topical: for wounds. Also works cosmetically on wrinkles – temporarily tightens the skin.

Dose: 5-10g

Bai Tou Weng – Pulsatilla root – Chinese Anemone – “White-Headed Old Man”

Nature: bitter, cold

Enter: Large Intestine, Liver, Stomach

Actions: Cools the blood; clears heat; eliminates toxicity.

Indications:
• Key herb for dysentery (bacterial or amebic) due to damp-heat or heat-toxicity: fever, abdominal pain, loose stools with pus and blood, tenesmus. Can be used alone for this.
• Effective in treating scrofula after it has ulcerated and when healing is slow.
Hsu: Anti-trichomonas; antiamebic; cardiotonic effects, dilates peripheral vessels.
K&R: (P. vulgaris – Pasque flower) Antispasmodic, emmenagogue, sedative, estrogen antagonist, sympatholytic. Wood excess.
• One of the best plants to drain repletion of Liver Yang, the whole plant is used to treat symptoms of Liver fire, hyperthyroid symptoms, tachycardia, neuralgia, migraines, bronchial spasms of pertussis, allergic rhinitis and asthma, spasms of colonopathy on the right side, colitis, dysmenorrhea, liver congestion, symptoms of depression with the sudden mood swings of menopause, pain in the pelvic and genital area, pelvic congestion, hysteria, phobias, anguish.
• Also has diaphoretic and diuretic properties.
• All parts of the fresh plant are dangerous, causing nausea, vomiting, diarrhea, intestinal spasms, skin inflammation, and asphyxiation.
RW: (P. vulgaris) Take internally for inner eye conditions: iritis, scleritis, disease of the retina, and above all, grey or senile cataract and glaucoma. (More effectiveness in glaucoma than cataract.)
IBIS: Affinities: female reproductive tract.
• Sedative, analgesic, antispasmodic, antibacterial.
[Western] dosage: tincture: 0.1 – 10 gtt. t.i.d.; up to 60 gtt. t.i.d. (Hoffman).
• Therapy: toothache, insomnia, headache, depression/irritability, nervous conditions; dysmenorrhea, amenorrhea, leukorrhea, spasm in reproductive system; skin infections, respiratory tract infections, asthma.
• Contraindicated for use in pregnancy; uterine stimulant and gastrointestinal irritant (De Smet, Farnsworth).
• Contraindicated for nursing mothers because of its gastrointestinal irritant effect (Brinker, Brooks).

Dose: 6-15g

Bai Xian Pi – Dictamnus root bark – Chinese dittany – “White Fresh Bark”

Nature: bitter, cold

Enters: Spleen, Stomach

Actions: Dries dampness; eases itching; clears heat; eliminates toxicity; expels wind.

Indications:
• Damp-heat: carbuncles, eczema with copious yellow discharge or pus and itching. Also for wind-heat skin conditions.
• Damp-heat: jaundice or Bi syndrome (used in combination with other herbs).
MLT: For fungal diseases associated with itching, especially effective when combined with Ku shen.
Hsu: Antipyretic, antifungal.

Dose: 6-9g

Ban Bian Lian – Chinese Lobelia – “Half-Edged Lily”

Nature: acrid, cold

Enters: Heart, Small Intestine, Lung

Actions: Helps the Lungs descend fluids to the bladder, promotes urination, relieves edema; disperses the Lungs; clears heat; eliminates toxicity; cools the blood.

Indications:
• Heat and toxicity, poisons and venoms: snake bite, bee or wasp sting; also for swelling and pain from furuncles; fire toxin patterns including tonsilitis. Herb of choice for bites and stings – may be used internally or topically.
• Retention of harmful fluid: edema (often floating edema), ascites, mid- or end-stage schistosomiasis.
• Bensky/Gamble classifies with herbs that drain dampness.
• Not to be confused with the North American herb Lobelia inflata.
MLT: Cancer: anti-neoplastic properties.
Hsu: Diuretic, hypotensive, hemostatic.

Dose: 15-30g

Ban Lan Gen – Isatis root or Baphicacanthus

Nature: bitter, cold

Enters: Heart, Lung, Stomach

Actions: Clears heat; eliminates toxicity; cools the blood; benefits the throat; strongly relieves swelling and disperses stagnation.

Indications:
• Warm febrile diseases, warm epidemic disorders.
• Swelling: painful, swollen, sore throat, mumps.
• Damp-heat: jaundice.
• Very broad spectrum and powerful antiviral and antimicrobial effects.
• Viral infections: quite effective for encephalitis B, hepatitis A, B and C, EPI’s.
MLT: Ban lan gen and Da qing ye are the most powerful anti-viral herbs in all of herbal medicine.
• Good for skin blotches from heat in the blood.
• Agent Orange disease.
• Similar to Western Baptisia tinctoria (Wild Indigo).
SD: May help antidote lead poisoning.
DY: With Shan dou gen for mutual reinforcement, to clear heat, eliminate toxicity, and strongly disinhibit the throat. For such indications as:
– 1. Painful, red, and swollen throat due to replete heat. This combination is usually sufficient to treat severe throat inflammations (including strep throat, tonsillitis, pharyngitis, laryngitis, etc.) due to heat-toxins or replete heat. However, when this combination needs further reinforcement, add She gan, Jin yin hua, Lian qiao, Xuan shen, and Gan cao.
– 2. Toothache and painful, swollen gums due to replete heat.
– 3. Oral ulcers due to replete heat.
• With Xuan shen to clear heat, resolve toxins, cool the blood, nourish Yin, downbear fire, disinhibit the throat, disperse swelling, and stop pain. For painful, red, swollen throat with dry, red tongue, and a fine, rapid pulse due to Yin deficiency generating a deficiency fire or replete fire which damages Yin. For heat-toxins, add Shan dou gen and Gan cao. For deficiency fire, add Mai men dong and Sheng di huang.

Dose: 15-30g

Ban Zhi Lian – Scutellaria barbata – Barbat Skullcap – Bearded Scute – “Half-Branch Lotus”

Nature: acrid, cold

Enters: Lung, Large Intestine, Small Intestine, Liver, Stomach

Actions: Promotes urination to relieve edema; clears heat; eliminates toxicity; invigorates the blood, promotes movement and disperses in the course of clearing.

Indications:
• Cancer (heat and toxicity): Lung, stomach, intestines. (One study seemed to indicate that this herb alone is not a cure.)
• Heat and toxicity: carbuncles, snake bite, abscesses, furuncles, sores, trauma.
• Retention of harmful fluid: ascites.
• Chronic hepatitis.

Dose: 15-60g

Chuan Xin Lian – Andrographis – Green Chiretta – Kariyat – “Thread-the-Heart Lotus”

Nature: bitter, cold

Enters: Small Intestine, Large Intestine, Lung, Stomach

Actions: Dries dampness; clears heat; eliminates toxicity.

Indications:
• Damp-heat: dysentery, painful urination, eczema.
• Early stage warm-heat pathogenic invasion: fever, swollen, painful throat, headache.
• Lung heat: cough
• Lung heat and toxicity: abscess.
• Fire-toxin manifestations on the skin: sores, carbuncles.
• Topical: for eczema, snake bite (used fresh for snake bite). Often used in ointment for eczema.
• May be useful for prostate enlargement.
• Upregulates TH1 immunity (i.e., Wei Qi) – useful in acute infection.
• Recent use for loptospirosis.
• For common cold, one study indicated that 3-6g a day shortened duration of infection and mitigated symptoms.
Chuan xin lian can be used as an inexpensive substitute for Huang lian (in some cases).
• Exceedingly, overwhelmingly bitter. Can injure stomach Qi. Over 15g can cause nausea and/or vomiting. When taking it directly as a powder, it is often encapsulated.
PPP: Stimulates the immune system, especially phagocytic activity; stimulates bile production and flow; protects the liver from toxins; counters the damaging effects of free radicals; antiinflammatory; antiplatelet; abortifacient [contraindicated in pregnancy, though Chinese sources do not corroborate this].
• Used in Ayurveda for bitter tonic, stomachic, antipyretic, and laxative properties. Said to increase appetite, strengthen digestion, and diminish flatulence, hyperacidity and biliousness [probably in very small doses].
• Traditional uses include: loss of appetite, atonic dyspepsia, flatulence, diarrhea, dysentery, gastroenteritis, bowel complaints of children, liver infections, diabetes, general debility and convalescence after fevers, respiratory and skin infections.
• Indications supported by clinical trials: bacterial and viral infections including the common cold and pharyngotonsilitis, enteric infections; for prevention of urinary tract infections following shock wave lithotripsy, prophylaxis of common cold.

Examine.com:

Andrographis paniculata (King of Bitters) is an Ayurvedic herb traditionally used for anti-cancer and liver protective effects, and is a Traditional Chinese Medicine for the common cold. Unlike many herbs, most of the bioactivities of Andrographis paniculata can be traced back to a single diterpene molecule known as Andrographolide.

First and foremost, it does appear to be effective for the common cold when taken for 3-5 days after the symptoms first arise. There is surprisingly little evidence for the herb per se (two studies in humans) while much more research tends to use combination therapy of Andrographis paniculata and Siberian Ginseng (Eleutherococcus senticoccus). This combination therapy has been used in traditional medicine and called Kan Jang, and consists of most of the research.

In regards to cancer, Andrographis paniculata appears to have anti-proliferative effects that occur at low concentrations in vitro (not too far off from what is observed following oral ingestion) and limited animal models suggest that anti-proliferative effects of Andrographolide (the bioactive) are relevant following oral ingestion. It does not seem to be too potent in actually inducing apoptosis of cancer cells in animals however, and seems to be more related to merely preventing proliferation.

Safety wise, it appears to be safe acutely and no significant side-effects are noted with consumption of Andrographis paniculata either in isolation or via Kan Jang tablets when taken in a rehabilitative manner for 3-5 days. For prolonged and high dose usage, there is mixed evidence in regards to the testicles (some studies suggesting toxicity, some other studies using the same methods failing to note toxicity; reasons for the difference unknown) and the liver (although most studies not it is highly hepatoprotective, one study in humans noted an elevation of liver enzymes after 60 days that started to normalize when stopping the supplement; reason for this also unknown).

Overall, although there is a lot of promise associated with Andrographolide in general for a wide variety of purposes it is currently seen as effective for acute usage to alleviate symptoms of the common cold or flu.

When looking at the basic root extract (not concentrated in any way), the oral dose of Andrographis paniculata is in the range of 2,000-6,000 mg. The root extract tends to have an andrographolide content in the 1-2%, range with up to 4% having been reported.

When looking at extracts, 200 mg appears to be effective if the andrographolide content is around 30% or so.

In looking at the variability of how much Andrographolide can actually exist in the plant, I would think standardization of this plant (ie. Andrographis Paniculata standardized to 5% Andrographolide) is pretty important; otherwise the effects could be unreliable.

Also, enhancing absorption of Andrographolide via P-glycoprotein inhibition shouldn’t be needed at low oral doses; it only becomes needed when taking high doses.

1. Sources and Composition

 

1.1. Sources

Andrographis Paniculata (of the family Acanthaceae) is a herb with traditional usage for fighting off colds and infection (usually in Chinese medicine[6])[7][8] although antibacterial, antifungal, antiviral, choleretic, hypoglycemic, hypocholesterolemic, and Adaptogen-like effects have been reported as well as being a gastric (stomach) and hepatic (liver) tonic.[9] The usage of Andrographis Paniculata as a liver tonic is seen more in Ayurveda than it is in Traditional Chinese medicine[6] and is used as an anti-neoplastic agent in Ayuredic medicine.[10][6]

It also goes by the names Chiretta (or Chirayetah in Urdu), King of Bitters (as a testament to its bitter properties in Traditional medicine as well as taste), and Kalmegh (Hindi);[8][9] in english it is referred to as Creat[9] and in Traditional Chinese Medicine it is referred to as Chuanxinlian, Yijianxi or Lanhelian.[9] It is a component of a Chinese medication known as Xiang-Qi-Tang alongside Astragalus membranaceus and Cyperus rotundus.[11]

Although all parts of the plant have traditionally been reported at times, the leaves are the most common medicinal part of this plant.[9]

Has usage in traditional medicine for both being a liver tonic and anti-cancer agent (Ayurvedic medicine) and is most popular for its usage in Traditional Chinese Medicine for reducing the severity and length of cold/flu symptoms

 

1.2. Composition

Andrographis Paniculata tends to contain in the leaves:

  • Andrographolide at (commonly seen as the main bioactive[12][8] at 24.72-43.16mg/g in the flowers[13] but 0.81-1.86% (81-186mg/g) overall[14]) with up to 4% being reported.[12]
  • Isoandrographolide, Bisandrographolide A[15] and Neoandrographolide (16.65+/-4.48 mg/g in the cotyledons[13])
  • 14-deoxy-11,12-didehydroandrographolide
  • 14-deoxyandrographolide at 10.67-24.54mg/g (1-2.5%)[13] with highest content in young leaves[13]
  • Andrograpanin[12]
  • Skullcapflavone I
  • 7-O-Methylwogonin[12]
  • Various methoxyflavones[16][17][18][19]
  • 3,4-Dicaffeoylquinic acid[12]
  • Onysilin[12]
  • ?-sitosterol, stigmasterol, and ergosterol peroxide[18]

Despite the above quantification of Diterpenoids (Andrographolide and related names), products derived from the herbs tend to have variable quantities (market assessment of products);[20] and one review[12] noting that the Andrographolide content in the leaves can vary from between 0.5% and 6% dry weight.[20][21][22]

The Andrographolide class of nutrients are the active ingredients, and in the plants themselves they have large variability

 

2. Molecular Targets

 

2.1. TRPs

TRPV4 is a calcium channel that, upon activation, increases intracellular calcium and has been implicated in osmoregulation, nociception, regulation of vascular tone, and heat sensation[23] with some possible roles in heat regulation[24] and usually the pharmacological goal is to antagonize the channel.[23]

Bisandrographolide A has been noted to be an agonist of the TRPV4 receptor with an EC50 of 790-950nM without having any affinity for TRPV1-3; Andrographolide per se was inactive on any receptor.[15]

One of the secondary bioactives is a potent and highly selective TRPV4 receptor activator

 

3. Pharmacology

 

3.1. Absorption

In an oral bioavailability in rats using 20mg/kg of Andrographolide Paniculata (1mg/kg Andrographolide) it was noted that serum Andrographolide has a bioavailability of 91% at this dose, with ten-fold the dose (10mg/kg Andrographolide) having a bioavailability of 21.4%[25] and one study using 120mg/kg Andrographolide noting a poor absorption rate of 2.67%.[26]

The decreasing bioavailability with higher doses appears to be related to excessive P-Glycoprotein efflux, and incubation with Vermapril can increase its absorption and accumulation into cells.[26]

Appears to have great absorption at low doses (1mg/kg in rats, equivalent of 0.16mg/kg in humans or about 11mg for a 150lb human) with progressively reduced absorption at higher doses; this may underlie its apparently high toxicity threshold (large safety buffer)

 

3.2. Serum

In rats fed 20mg/kg Andrographolide Paniculata (1mg/kg Andrographolide) it was noted that Andrographolide had a Cmax of 1.273mcg/mL at a Tmax of 2.41 hours with an AUC of 7.09mcg/h/mL and a half-life of 2.4 hours.[25]

In rats fed 200mg/kg Andrographolide Paniculata (10mg/kg Andrographolide) it was noted that Andrographolide had a Cmax of 3mcg/mL at a Tmax of 1.67 hours with an AUC of 15.07mcg/h/mL and a half-life of 2.9 hours.[25]

In humans using Kan Jang capsules (combination Andrographolide and Acanthapanax senticocus) totalling 17mg Andrographolide, oral consumption resulted in a serum concentration of 141.7+/-20ng/mL with an approximately Tmax of 1.36 hours and a half-life of about 25 minutes, with no detectable Andrographolide detectable in the blood 8 hours after oral administration (some persons having no serum levels after 4 hours).[25] The authors the hypothesized what the steady state value would be following traditional usage (this dose, taken thrice a day) and calculated 660ng/mL; human values obtained in this study were predicted well with rat parameters obtained earlier, suggest they are similar.[25] One other study in healthy male volunteers noted a Tmax at 1.6 hours with a Cmax of 58.62ng/mL following oral ingestion of 200mg isolated Andrographolide.[27]

 

3.3. Metabolism

Following ingestion of Andrographolide, sulfated metabolites are found in the urine[28] and in particular 14-deoxy-12(R)-sulfoandrographolide[29] whcih appears to be structurally identical to an anti-inflammatory drug marketing in China under the name Lianbizhi.[30]|published=1981 Aug|authors=Meng ZM|journal=Yao Xue Xue Bao][26]

 

3.4. Distribution

Andrographolide has been noted to bind to bovine serum albumin (BSA) with an association constant of 2.59 and 5.52 binding sites and maximal binding of 79.2%.[25] 64% of Andrographolide is thought to bind to Bovine Serum Albumin at physiological concentrations, and 55% to human serum albumin.[25]

Andrographolide has been noted to distribute into tissues of persons consuming it with variability, with this study noting that it was fairly rapid tissue accumulation after absorption in 25% of the sample (n=4) with accumulation occurring after 1.5-3 hours in the rest of the sample.[25]

 

3.5. Excretion

It appears that minimal Andrographolide per se is excreted in the urine (rats), with 8.2% of the oral dose beinge excreted in the urine within 72 hours (8.75% overall) and having an elimination rate of 0.128 hours-1 and renal clearance of -0.028 ml/min.[25] The authors suspected with metabolic transformation or fecal excretion accounted for the majority.[25]

 

3.6. Phase I Enzyme Interactions

An ethanolic extract of andrographis paniculata appears to have mixed type inhibitory potential against CYP2C19 with a IC50 of 91.7?g/mL.[31] The methanolic and hexane extracts were weak inhibitors (IC50 values of 123.3?g/mL and 107.1?g/mL; respectively), the water extract showed no inhibitory potential, and andrographolide itself was very ineffective (IC50 greater than 1426.7?M).[31]

 

3.7. Phase II Enzyme Interactions

Andrographus paniculata (95% ethanolic extract) appears to exert relatively potent inhibitory effects against various enzymes of drug metabolism including UGT1A1 (IC50 of 5?g/mL), UGT1A3 (1.7?g/mL), UGT1A6 (5.66?g/mL), UGT1A7 (9.88?g/mL), UGT1A8 (2.57?g/mL), UGT1A10 (15.66?g/mL), UGT2B7 (2.82?g/mL) although the inhibitory effects on UGT1B15 were greater than 50?g/mL.[32]

 

4. Neurology

 

4.1. Neuroinflammation

0.78mg/kg of Andrographis Paniculata in mice for a week prior to LPS injections (pro-inflammatory stimuli) noted that CXCL2 (aka. MIP2) mRNA was significantly suppressed relative to LPS control; 1.52-3.12mg/kg were less effective, but as effective as the active control of 50mg/kg pyrrolidine dithiocarbamate.[33] This study also noted no significant influence of MIP2 mRNA in the liver of the same mice, suggesting a localized effect.[33] MIP-2 is involved in neutrophil accumulation[34] and when active in the brain have been noted to increase blood-brain barrier permeability to immune cells to facilitate recruitment.[35]

 

5. Cardiovascular Health

 

5.1. Cardiac Tissue

Incubation of cardiac muscle with 5-320uM of 14-deoxy-11,12-didehydroandrographolide (DDS) has been noted to cause a concentration-dependent reduction in the rate of atrail beating (heart rate).[36]

 

5.2. Blood pressure

14-deoxy-11,12-didehydroandrographolide (DDS) appears to cause dose-dependent reductions in blood pressure[37][36] (which has led to it’s quantity being restriced in some supplements to avoid possible hypotension[8]). DDS is more effective at reducing blood pressure than andrographolide and neoandrographolide in vivo[37] and appears to have an ED50 value of 3.43mmol/kg (in anaesthetised rats).[36]

The reduction in blood pressure appears to be mediated via adrenoreceptors, and is thought to act as a beta-blocker (antagonist of the beta-adrenoreceptors) as captopril and propanolol both attenuated the effects with the latter nearly abolishing it.[36]

 

5.3. Platelet

Andrographolide is able to concentration-dependently (25-100uM) cause apoptosis of platelets via a mitochondrial dependent pathway, which was inhibited by the caspase-8 inhibitor z-IETD-fmk (suggesting capsase-8 is critical to Andrographolide-mediated apoptosis).[38]

 

6. Interactions with Immunology

 

6.1. Mechanisms

In LPS-activated macrophages, 14-deoxy-14,15-dehydroandrographolide was able to inhibit nF-kB activation with an IC50 of 2?g/mL[18] although up to 10-20?g/mL of the ethyl acetate extract from Andrographis Paniculata is required for such inhibition.[33] At least one study noted that in vitro efficacy of the plant extract (ethyl acetate) is similar to Morus alba and Eucommia ulmodes leaves while being more effective than Astragalus membranaceus and trended to be less effective than Isatis indigotica (all tested in vitro between 2-5?g/mL).[33]

This has been noted elsewhere with the ethyl acetate fraction of Andrographis Paniculata following oral ingestion of 0.78-3.13mg/kg in mice injected with LPS after Andrographis feeding for a week; this study noted that 6.25mg/kg failed to reduce lethality from LPS like lower doses.[33]

Some compounds may have anti-inflammatory effects, with fairly potent effects in vitro

At 1µM, lymphocyte proliferation and IL-2 secretion is enhanced by Andrographolide (14%), 14-deoxyandrographolide (5%), and 14-deoxy-11,12-didehydroandrographolide (7%) although the dichloromethane and methanolic extracts (which contain these molecules) are more potent, suggesting synergism from other bioactives.[39]

On immune cells, Andrographolide may possess weak to moderate immunostimulatory properties

 

6.2. T-Cells

15-30mg Andrographolide daily for up to 6 weeks has been noted to decrease CD4+ T-cell count by 27% in healthy control persons after 6 weeks while increasing CD4+ cell count in persons with HIV by 23.7% at 6 weeks.[40]

 

6.3. Sickness and Infection

Andrographis Paniculata is a popular Traditional Chinese Medicine for the purposes of reducing cold and flu symptoms. Surprisingly, this herb may not possess any anti-bacterial effects.[41]

In persons (n=152) with pharyngotonsillitis, daily ingestion of 3-6g of Andrographis Paniculata were effective at reducing signs and symptoms of pharyngotonsillitis with the higher dose (6g) being as effective as the active control of Paracetemol (Tylenol).[42] Benefits were seen on day three of treatment, with no further benefit seen when measured on day 7.[42]

In persons with uncomplicated Upper Respiratory Tract Infection (URTI) taking 200mg of an extract from the leaves of Andrographis Paniculata (31.3% Andrographolide) in two divided doses of 100mg daily for 5 days noted that while there were no differences between groups at baseline or at three days that on day 5 the Andrographis group experienced reduced symptoms (such as Expectoration, Headache, Cough, Fever, and Fatigue; Earache was the only unaffected parameter).[8] These seemingly general benefits are also noted with 1200mg of the basic plant extract, where 4 days of supplementation was able to reduce all measured symptoms of the common cold relative to placebo while sore throat, nasal secretion, and earache were significantly reduced after 2 days.[43]

In regards to Andrographis alone, it appears to be effective in a general manner against respiratory infections

For the purposes of general immunity, Andrographis Paniculata appears to be used in combination with Siberian Ginseng (Eleutherococcus senticoccus), which is either known as SHA-10 (standardization) or ‘Kan Jang’ tablets; the latter due to the combination also being used in Traditional Chinese Medicine.[1] There appears to be a large amount of human studies originating from Russia in support of this combination (cited from this study,[1] cannot be located online and conducted between 1967-1995).

A pilot study using Kan Jang tablets (SHA-10) with both Andrographis Paniculata (85mg standaridized for 5.25mg Andrographolide plus Deoxyandrographolide) and Siberian Ginseng (9.7mg containing 2% Eleuthroside B and E) with four tablets taken thrice a day (63mg Andrographolides and 116mg Siberian Ginseng daily) noted that the improvement in overall symptoms in persons with URTIs were to a greater degree than placebo over 5 days.[1] These results were later replicated in a Phase III Trial of 180 persons, where Kan Jang capsules at this dose outperformed placebo over the course of 5 days in reducing symptoms from URTI.[1] Similar effects have been replicated elsewhere in a sample of 185 persons using similar dosing, although this latter study noted a larger effect size (while placebo experienced a 23% reduction in symptoms, Kan Jang experienced an 86% reduction) with most significant improvement in throat symptoms (dry and soreness), headache, malaise, sneezing, and runny nose with some efficacy on cough.[2]

One comparative study pitting Kan Jang capsules against Echinacea purpurea using either for a 10 day period in children with colds noted that Kan Jang was significantly more effective than Echinacea.[4]

One study using Kan Jang capsules with additional Schizandra chinensis and Licorice (48mg Andrographolide daily) for one month has noted significantly less symptoms (relative to placebo) in persons with Familial Mediterranean Fever.[5]

Kan Jang tablets (combination therapy of Andrographis paniculata and Eleutherococcus senticoccus) appears to be effective in reducing the signs and symptoms of upper respiratory tract infections when taken at the onset of sickness. At least one study suggests it is more potent than Echinacea purpuera

 

6.4. Virology

In 13 HIV-positive persons given Andrographolide (PN355) at 5mg thrice a day (totalling 15mg) for 3 weeks in escalating dose (10mg for another 3 weeks with the trial ending at 6 weeks) noted a high degree of side-effects associated with treatment (no placebo for comparison) and noted an increase in hepatic enzymes (ALT and AST) associated with treatment and normalized 3 weeks after cessation.[40] There was no influence on HIV RNA content.[40]

 

6.5. Arthritis

Supplementation of Andrographis extract (30% Andrographolide) at three daily doses of 100mg (300mg daily) for 14 weeks in persons with Rheumatoid arthritis failed to significantly reduce joint pain although both the count and degree of tender and swollen joints was significantly reduced with Andrographis intervention.[44] This study also noted reduced serum IgA and complement component C4.[44]

At least one study noted that Andrographis may reduce swelling (but not significantly reduce pain) associated with Rheumatoid Arthritis

 

7. Interactions with Hormones

 

7.1. Testosterone

One study using 20-1000mg/kg of Andrographis Paniculata (10.9% Andrographolide) daily for 60 days has failed to find any significant influence on circulating testosterone levels.[45]

 

8. Interactions with Organ Systems

 

8.1. Liver

Mechanistically, in HepG2 cells treated with CCL4 both Andrographolide and Andrographis paniculata extract (2.7% Andrographolide) exert cytoprotection when coincubated with maximal protective effects at 30µmol/mL Andrographolide which preserved 84.3% of cell viability (higher concentrations not tested);[46] this was said to be due to its antioxidative capacity (IC50 of 3.2µg/mL (9.2µmol/mL) in DPPH assay with a maximum potency at 15µmol/mL, more potent than Vitamin C which had an IC40 of 4.2µg/mL and reached maximal potency at 40µmol/mL).[46] Protective effects against CCL4 hepatotoxicity have been noted in vivo when mice were pretreated for 8 days with 50-100mg/kg Andrographolide, where only the higher dose of 100mg/kg was associated with a reduction of ALT and AST enzyme secretion with reduced MDA (indicative of lipid peroxidation) and increased glutathione; 100mg/kg Andrographolide was equally effective as the active control of 100mg/kg Silymarins (from Milk Thistle).[47]

Andrographolide has also shown protective effects in H4IIEC3/G(-) liver cells induced with acetominophen toxicity, where 10µM of Andrographolide preserved 55% of cell viability and outperformed 10µM of Kutkin from Picrorhiza kurroa (46%) and Silymarin (24%).[48]

Appears to have general hepatoprotective properties against pro-oxidative toxins, with one study suggesting it is dose-for-dose as effective as Silymarins from Milk Thistle (although Andrographus paniculata supplements tend to be dosed much lower inherently)

One pilot study in persons with HIV (small group of persons without HIV) noted that treatment of 15-30mg Andrographolide in three divided doses was associated with an increase in serum liver enzymes (AST and ALT) in both groups, with the HIV group normalizing liver enzymes 3 weeks after supplement cessation.[40]

 

8.2. Lung

Andrographolide pretreatment to mice 2 hours prior to exposure to smoke fumes has been noted to be associated with less fluid accumulation and changes in biomarkers thought to be due to antioxidative effects (reduced lipid peroxidation and increase antioxidative enzymes); this was thought to be downstream of Nrf2 activation, which was noted in vitro (BEAS-2B cells) to be induced by Andrographolide treatment.[49]

 

8.3. Kidneys

In a series of case studies of persons who underwent Extracorporeal Shock Wave Lithotripsy (ESWL; a kidney stone treatment[50]) given two doses of 1,000mg Andrographis Paniculata daily for 5 days following treatment noted reductions in pre and post-ESWL pyuria, hematuria and proteinuria of similar potency to the active controls of Norfloxacin (200mg) or Cotrimoxazole.[51] These results suggest that Andrographis Paniculata has renoprotective properties.

 

8.4. Intestines

In animals with colitis given a water extract of Andrographis Paniculata, inhibition of CD4+ T-cell differentiation into TH1/TH17 cells was said to underlie the observed protective effects of supplementation where the signs and symptoms of colitis were abolished in mice recieving both supplementation and methyl celluose (which induced the colitis);[52] this study is duplicated in Medline.[53]

An extract known as HMPL-004 at 1200mg (thrice daily dosing of 400mg) in persons with Ulcerative Colitis daily for 54 days (on average) noted that the rate of clinical remission was 21% (clinical signs) or 28% (colonoscopy) with the rate of response being 76% and 82% (clinical and colonoscopy, respectively); the active control of 4500mg Slow-Release Mesalazine achieved similar rates of remission (16% and 24%, respectively) and response (74% and 71%).[54] Another trial using 1200mg and 1800mg in adults with mild-to-moderate colitis noted a dose-dependent increase in ‘response to treatment’ (reduction of symptoms associated with colitis) which trended towards significance at 1200mg but was significant at 1800mg; no significant differences were noted in side-effects relative to placebo.[55]

Appears to show promise in Ulcerative Colitis, with one double-blind and one comparative study coming back positive currently

 

8.5. Testes

Interestingly, one study on Eurycoma Longifolia Jack showed the efficacy of said supplement in a rat model of “Andrographis Paniculata induced infertile rats”.[56] This may have originated from a study in male albino rats where 20mg powder for 60 days induced infertility and a cessation of spermatogenesis[57] and another study noting that 25-50mg/kg isolated Andrographolide for 48 days inducted testicular toxicity and altered spermatozoa.[58]

In opposition to the above, doses of 1000mg/kg Andrographis Paniculata (6.1% Andrographolide) for 60 days in male rats has failed to exert appreciable testicular toxicity[22] and these lack of effects persist when looking at fertility of male rats over 65 days, where the lack of testicular toxicity was replicated.[45] It should be noted that the latter two studies appear to have better methodology than the former two (involving electron microscope analysis of testicular histology and measuring serum levels of biomarkers).[45]

Additionally, a Phase I trial in healthy humans using Kan Jang capsules (the anti-cold Chinese Medicine where Andrographis is paired with Siberian Ginseng) at thrice the recommended dose for 10 days failed to find any toxic effects on sperm cells.[3]

Has been implicated in inducing testicular toxicity, although this is a contested issue and the one human study using feasible oral doses has failed to find any signs of testicular toxicity

 

Edit9. Interactions with Cancer

 

9.1. Immunological Interactions

In lymphocytes (obtained from volunteer) treated with 1?M Andrographolide, an increase in CD3 (61–91% relative to control lymphocytes), CD4+ (40–61%), CD8+ (23–31%), and CD56 (2–3%) marker expression was noted and associated with enhanced lymphocyte-mediated toxicity on K562 cancer cells; this was also noted to occur at 0.1?M.[59]

May enhance lymphocyte-mediated toxicity towards some cancer cells

Treatment of cancer cells with Andrographolide was associated with upregulation of Death-Receptor 4 (DR4) which enhanced TRAIL-mediated apoptosis; this was downstream of p53 induction and abolished with coincubation of N-Acetylcysteine (and thus was mediated by pro-oxidative mechanisms).[60] TRAIL is a selectively tumor cytotoxic agent from the immune system[61] which is a therapeutic target in cancer research.[6][62]

Appears to enhance TRAIL-mediated cytotoxicity in cancer cells via pro-oxidative (possibly hormetic) means

Andrographolide is able to enhance cytotoxicity of reference cytotoxic drugs (5-fluorouracil, adriamycin, and cisplatin) when coincubated in multi-drug resistant colorectal cells[63] where it synergistically enhances the cytotoxicity of other agents.[64]

May confer aid in multi-drug resistant cells

 

9.2. Colon Cancer

In human colorectal carcinoma cells (Lovo) noted that Andrographolide was accumulated up to 0.61+/-0.07?M/mg (12 hours) in cells and displayed a IC50 on cell growth of 8.6?M at 24 hours, with 48 hours incubation of 10-30?M causing near inhibition of proliferation.[65] One study assessing a wide variety of tumor cell lines noted that while the IC50 ranged from 5-15?M that one colon cell line (COLO205) was more sensitive with an IC50 of less than 1?M, although inhibitory effects were noted on all five tested colon cancer cell lines (SW620, HCT116, HT29, KM12, and COLO205)[59] and elsewhere noted to be 11?M on SW620.[39] Andrographolide is not the only molecule in Andrographis Paniculata to have cytotoxic effects on colon cancer cells, but the methylated flavones appear to have higher IC50 values (less potency) and most other diterpenes related to Andrographolide are about 3-fold less effective, although this study noted that 14-deoxy-14,15-didehydroandrographolide was similarly effective on COLO205 cells;[66] this potency of Andrographolide relative to other diterpenes has been noted in Leukeia cells as well.[67]

Andrographolide appears to have potent anti-proliferative effects on a wide variety of colon cancer cells; the cytotoxic effects (ability to kill cells, in this context we mean tumor cells) of Andrographolide are currently not as well researched and some sources hint at it being quite less potent or unremarkable

Andrographolide has been noted to accumulate cells in the G1 phase of the cell cycle (43.28% to 56.05% at 10?M) with a decrease in S fraction in a concentration and time dependent manner; this was associated with a downregulation of Cyclin D1 (no significant influence on Cyclin D3 or E although both Cdk2 and Cdk4 were reduced in protein content) all thought to be downstream of p53 induction of protein content and phosphorylation.[65]

An increase in the Rb/E2F complex has been noted with Andrographolide,[65] and secondary to more of this complex less free E2F is released; E2F being a factor in cell proliferation and its complexation reducing proliferation.[68] One other study has noted anti-invasive effects of Androgapholide on colon cancer cells (CT26 and HT29) although attributed this observation to inhibition of MMP2 (and inhibition of Akt),[69] a protein that promotes invasiveness of tumor cells. Studies in lung cancer cells suggest that MMP2 inhibition may also be downstream of HLJ1 upregulation.[70]

The anti-proliferative effects appear to be mediated by modulation of Cyclin proteins, which appear to be downstream of p53; other evidence (not on colorectal cells) hints that p53 is downstream of prooxidative and hormetic effects

 

9.3. Breast

Andrographolide has been noted to induce apoptosis in breast cancer cells at 0.35-1.4mM in TD-47 breast cancer cells in a concentration and time dependent manner, with apoptosis at 24 hours ranging from 28.55-65.65% and at 72 hours ranging from 76.48-99.72%.[71] This apoptosis was associated with DNA fragmentation associated with an increase in p53 content,[71] and has been noted to be a pathway independent of the mitochondria.[72]

The related structure 14-deoxy-11,12-didehydroandrographolide has been shown to induce both apoptosis and autophagic structures (visually assessed) in TD47 breast cancer cells at 1.5?g/ml[73] (the IC50 found here[74]) and these changes were associated with 2-fold modifications of genes involved in cell cycles (19), cell growth and proliferation (42), tumor suppression (40), apoptosis-related mechanisms (18), and vesicle formation and transport as well as protein degradation (30); all named within the citation.[73]

An increase in G1 phase cells with concomitant decrease in S phase (as well as G2/M) has been noted in MCF-7 cells (treated with 5?M Andrographolide) at 24 hours with an increase in sub-G1 cell content at 48 hours.[59] Andrographolide was noted to induce p27 content and subsequent downregulation of Cdk4 (at 25?M).[59]

There is apparent cytotoxicity associated with Andrographolide in brast cancer cells, but at a very high concentration that may not be practically relevant

Growth inhibitory effects have been noted on four breast cancer cell lines (MDA-MB-453, MCF7, MCF7/ADR and T47D) with an IC50 value ranging from 5-15?M[59] and another study using NCI/ADR-RES noting an IC50 of 15?M with Andrographolide and 30?M with 14-Deoxy-11,12-didehydroandrographolide.[39]

There appears to be standard anti-proliferative effects at fairly low concentrations of Andrographolide

Anti-tumor activities of Andrographolide have been confirmed in vivo in mice transplanted with tumors, and was associated with PI3K/Akt and suppression of angiogenetic factors such as VEGF and Osteopontin.[72]

 

9.4. Leukemia

In studies done on leukemic cells, it is noted that while Andrographolide has cytotoxic activity that both 14-deoxy-11,12-didehydroandrographolide and neoandrographide have failed to exert any cytotoxic activity[67] and that Andrographolide-mediated cytotoxicity in HL-60 leukemic cells occurs via mitochondria-dependent mechanisms.[75]

Subsequently, Andrographolide has shown anti-proliferative properties in two Leukemic cell lines (CCRF-CEM, RPMI8226) with an IC50 between 5-15?M[59] and in HL-60 leukemic cells a 27% increase in G0/G1 cell count at the expensive of S and G2/M at 12?g/mL over 36 hours.[75]

One study noting the IC50 of proliferation on Jurkat Lymphoma cells relative to healthy PMBCs noted that two dehydroandrgrapholides and Isoandrographolide had IC50 values of 50-100?M while the IC50 in healthy cells was either 150?M or ‘greater than 200?M’.[66]

Andrographolide has shown to have anti-proliferative effects in Leukemic cells at regular concentrations, with apoptosis being induced at higher concentrations

At least one study has noted that Andrographolide was able to influence differnetiaiton of myeloid leukemia (M1) cells of mice into phagocytes,[76] which is not a common mechanism among plant-derived nutraceuticals.[6]

 

9.5. Melanoma

Isolated Andrographolide has shown anti-proliferative effects in isolated Melanoma cells (A431, M14, UACC62) with an IC50 between 5-15?M[59] with another study using M14 cells noting an IC50 of 11?M.[39]

In mice planted with B16 melanoma tumors, oral ingestion of Andrographolide at 100-200mg/kg oral dose (human equivalent of 8-16mg/kg) was associated with a suppression of tumor growth at 30-36% (100mg/kg) and 39-52% (200mg/kg) over the course of 10 days.[59]

 

9.6. Ovarian

Isolated Andrographolide has been noted with inhibiting proliferation of four ovarian cancer cells (ES2, SKOV3, OVCAR8, and PA-1) with an IC50 between 5-15?M[59] with another study noting an IC50 (SKOV3) of 18?M.[39]

 

9.7. Prostate

Isolated Andrographolide has been noted with inhibiting proliferation of two prostate cancer cells (DU145 and PC3) with an IC50 between 5-15?M[59] with other studies noting growth inhibition (IC50) of 12?M (PC3)[39] and 70-150?M (PC3).[66]

 

9.8. CNS

Isolated Andrographolide has been noted with inhibiting proliferation of three CNS cancer cells (U251, SF268, and SNB19) with an IC50 between 5-15?M[59] with another study replicating these growth inhibitory effects on U251 with an IC50 of 10?M.[39]

In glioblastoma cells (U251 and U87) Andrographolide has been noted to inhibit proliferation in a concentration and time dependent manner between 10-100?M (no cytotoxicity noted) associated with G2/M arrest, increasing the percentage of cells in G2/M phase from 15.73% to 35.15% (123% increase in U251) and 16.99% to 33.61% (98% increase in U87) at 70?M.[77] This was associated with downregulation of Cdc25C and Cdk1 as well as slight inhibition of PI3K/Akt, although coincubation with a more potent PI3K/Akt inhibitor enhanced the anti-proliferative effects greatly.[77]

Anti-proliferative effects on glioblastoma cells appear to be synergistic with the mechanism of PI3K/Akt inhibition

 

9.9. Lung

Isolated Andrographolide has been noted with inhibiting proliferation of six tested lung cancer cells (A549, NCI-H23, HOP62, MES-SA, H522, and MES-SA-DX5) with an IC50 between 5-15?M[59] although another study using H522 noted an IC50 of 16?M.[39] Andrographolide has also been noted to enhance HLJ1 promoter activity secondary to JunB activation, which then caused suppressed activity of MMP2.[70]

 

9.10. Renal

Isolated Andrographolide has been noted with inhibiting proliferation of two renal cancer cells (ACHN and A498) with an IC50 between 5-15?M[59] although another study using A498 noted an IC50 on growth of 28?M.[39]

 

Edit10. Safety and Toxicity

 

10.1. General

In interventions with Andrographis Paniculata, side-effects do not appear to be significantly different than placebo[8][2][25][1] even in one instance where side-effects reached 20% of the study group (same as placebo, suggesting another factor was at play);[42] most reported side-effects (regardless of being different or similar as placebo) generally being mild and infrequent.[7]

One study in HIV positive persons has noted that, with isolated Andrographolide, some symptoms similar to an allergic reaction were reported (from two subjects, no placebo group in this study)[40] while according to manufacturers (data retrived here[7]) there have been 5 reported cases of allergic reactions associated with Andrographis Paniculata supplementation.

In general, human intervention data appears to show that commonly used doses of Andrographis Paniculata are safe; very few instances of allergic reactions or something sharing the symptoms has been reported

In rats, the LD50 appears to be greater than 17g/kg.[78]

Dose: 6-15g

Da Qing Ye – Isatis leaf or Baphicacanthus or Clerodendron or Polygonum tinctorium – “Big Bluegreen Leaf”

Nature: bitter, very cold

Enters: Heart, Lung, Stomach

Actions: Cools the blood, relieves skin eruptions; clears heat; eliminates toxicity.

Indications:
• Any warm-febrile disease or epidemic febrile outbreak.. Especially for epidemic toxin or any severe febrile disease that affects people regardless of their constitution, such as severe contagious disease.
• Heat and toxicity in the blood: swollen and painful throat, erysipelas, mouth ulcers.
Xue level heat and toxicity: coma, skin eruptions, high fever, restlessness.
• Heat in the blood: skin blotches, rashes, and other skin eruptions. Often used in cases with intense fever, irritability, and changes in consciousness.
• May be used for fire-toxicity anywhere in the body, especially the throat and Lungs.
• Very effective in treatment of encephalitis B; commonly used for meningitis.
• Acute dysentery, gastroenteritis.
• Antiviral, antimicrobial.
• Caution with spleen/stomach cold from deficiency.
SD: May help antidote lead poisoning.

Dose: 9-30g

Gui Zhen Cao – Bidens – “Demon/Ghost Spike/Needle Plant”

SD: It is said that the nature of the herb is sweet and bland, with a neutral property, though other sources list it as bitter. Its actions are to expel pathogenic factors from the surface of the body, clear up heat, remove toxin, and eliminate stagnancy. The applications listed include influenza, swollen and sore throat, enteritis, dysentery, jaundice, intestinal carbuncle, epilepsy in children, malnutrition in infants, and hemorrhoids.
In Chinese Medicinal Herbs of Hong Kong, the indications for Bidens pilosa (the only species listed) are: influenza, colds, fever, sore throat; acute appendicitis; acute infectious hepatitis; gastroenteritis, dyspepsia; rheumatic arthralgia; malaria; and hemorrhoids, pruritis.
Oriental Materia Medica reports it to have the functions of removing wind-dampness, dispersing stagnant blood, and invigorating blood. Applications of the herb include rheumatoid arthritis, sprain, insect and scorpion sting, diarrhea, dysentery, hepatitis, acute nephritis, stomach ache, and sore throat.
The substitute Desmodium species are similar to the standard herb known either as hulucha or longshehuang (Desmodium triquetri), which is applied to treat common cold, sore throat, enteritis, dysentery, jaundice, rheumatic arthralgia, and other disorders; the overlap in applications between bidens and desmodium is evident. A review of uses of Bidens bipinnata (the only species mentioned) is presented in Anticancer Medicinal Herbs, including:
Internal Medicine: “It is recorded in Handbook of Chinese Medicinal Herbs that: The decoction of the drug cures dysentery, laryngalgia, dysphagia, vomiting, cardiac spasm and esophageal dilatation, and is effective in
removing toxic materials, stopping diarrhea, and clearing away heat. The drug has been used to treat cecitis in the recent years.” For cancer therapy, 15″“30 grams per day is decocted and taken orally for esophageal cancer;
for gastric cancer, 15 grams of bidens is combined with a complex formula for daily administration.
External Medicine: “It is said in Prescriptions Worth a Thousand Gold that “˜External application of bidens with arctium and blended with pig fat can cure finger cut.’ It is recorded in Dictionary of Chinese Materia Medica that “˜The drug, bitter in taste, mild in nature, and non-toxic mainly cures spider and fly bites through internal and external application.’ It is reported in Materia Medica that “˜Scorpion sting can be cured by external application of the drug.'”
In Chinese-English Manual of Common-Used Herbs, under guizhencao, Bidens bipinnata, B. pilosa, and B. biternata are all listed as the source materials; the applications are: 1. clear away the superficial heat: for common cold of wind-heat type and prevention of influenza; 2. clear away heat and toxic materials: for sore throat, appendicitis, snake bite, and centipede bite; and 3. clear away dampness and heat from the gastrointestines [gastro-intestinal tract]: for diarrhea, dysentery and stomach ache of heat type.
The herb, along with others, is included in the Chinese Patent Gan Mao Qing, a remedy for common cold and influenza. For topical use, the fresh herb is crushed and applied locally or boiled in water to produce a wash for boils, eczema, and tinea.
Based on the traditional claims, bidens would be expected””from the modern perspective””to show infection-inhibiting and anti-inflammatory properties: these actions have been investigated and shown to exist. In fact, bidens extracts are shown to inhibit bacteria, fungi, and viruses and to have potent anti-inflammatory effects in laboratory animal experiments with induced gastric ulcer, liver inflammation, or arthritis-type swelling. In Anticancer Medicinal Herbs, the anticancer potential of the herb is said to be implied by its bacteria inhibiting actions (since many antibacterial substances also inhibit cancer).
Bidens tripartita (lang ba cao), which has been known for many centuries as a remedy for chronic dysentery, was used in a clinical trial to treat 500 cases of dysentery, 65 cases of acute enteritis, 248 cases of chronic enteritis.
In 500 cases of dysentery, 387 cases were reported cured; with 13 not responding in 3 days. In 313 cases of enteritis all were cured (12 chronic cases relapsed later). The authors of the study pointed out that there had been an epidemic of dysentery in Shandong Province for many years and that practitioners at village clinics and the county hospital in Jianan County had used bidens as a remedy for about 10,000 patients.
ITM Formulary: A dried hot water extract of bidens with other herbs has been prepared in tablet form under the name Bidens 6 (Seven Forests). The formula is: Bidens 25%, Hu zhang 20%, Zi hua di ding 15%, Ban lan gen 15%, Ju hua 15%, Gan cao 10%. All the herbs in this formula have anti-infection activities.

Dose: 9-60g (60-120g for acute appendicitis)

Hong Teng – Sargentodoxa vine – “Red Vine”

Nature: bitter, neutral

Enters: Large Intestine, Liver

Actions: Promotes blood circulation, disperses stasis, alleviates pain; clears heat; eliminates toxicity; reduces abscesses.

Indications:
• A key herb for appendicitis. For appendicitis, it is often used in high doses (60g) and is combined with herbs such as Pu gong ying, Da huang, and Hou po.
• Blood stasis: dysmenorrhea, trauma, joint pain.
• Wind-dampness: joint pain.
• Heat-toxicity: abscesses, skin lesions with heat, swelling, and pain.
• Prostatitis.
• Antibacterial.

Dose: 15-30g

Jin Yin Hua – Honeysuckle flower – Lonicera – “Gold Silver Flower”

Nature: sweet, cold

Enters: Lung, Stomach, Large Intestine

Actions: Clears heat; eliminates toxicity; expels wind-heat; clears lower Jiao damp-heat.

Indications:
• Wind-heat or early stage of warm-heat pathogenic invasion: fever, slight aversion to cold, slight sensitivity to wind, sore throat, headache. This herb can be applied to Wei, Qi, or Ying level heat invasion.
• Heat and toxicity: carbuncles, boils, dysentery, hot painful sores and swellings, arthritis, intestinal abscess. Especially useful for affections of the breast, throat, or eyes.
• Lower Jiao damp-heat: dysenteric disorder or painful urinary dysfunction.
• Externally contracted summer-heat.
• Tuberculosis.
• Chronic conjunctivitis, keratitis, corneal ulcers.
• By IM injection or injection into acupoints, Jin yin hua has proven useful in treating severe acute pneumonia and bacillary dysentery.
• Also for many purulent diseases including appendicitis with perforation, mastitis, erysipelas.
• Broad antimicrobial, antiviral. Anti-inflammatory.
• Not for yin-type ulcers or for sores due to Qi deficiency.
DY: For severe heat-toxicity, dysentery, or pyogenic skin infections, use 30-60g per day. High doses can be used without side effects.
• With Lian qiao to strongly and effectively clear heat and resolve toxins. For indications such as:
– 1. Colds and influenza due to wind-heat. (Yin Qiao San)
– 2. Warm diseases with internal heat. (Yin Qiao San)
– 3. Headache, eye pain, toothache, sinusitis, and painful, swollen throat due to wind-heat.
– 4. Skin eruptions with pruritis due to wind-heat.
– 5. Skin inflammation due to heat toxicity.
– Neither herb is acrid. They are often included in formulas for dispelling wind-heat to prevent the production of heat toxins or to prevent heat from entering deeper into the interior. They are able to limit the worsening of colds, influenza, and other illnesses due to wind-heat.HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas.
K&R: Water yin, fire yin. Diuretic, antiseptic, sudorific, febrifuge, oxytocic.
• Tonsilitis, strep, pyelonephritis, acute articular rheumatism.
• The leaf may accelerate childbirth.

Dose: 9-60g

 
Ren Dong Teng: the stem – “Stem that Resists Winter”
• Similar functions Jin yin hua, but does not disperse wind-heat.
• Also clears wind, heat, and dampness from the channels.
• Wind-damp-heat in the channels: hot, swollen, painful joints that are difficult to move (arthritis).
• Doctrine of signatures: the stem resembles a meridian – clears the meridians, treats the extremities.
15-30g

Lian Qiao – Forsythia fruit

Nature: bitter, slightly cold

Enters: Heart, Lung, Liver, Gallbladder

Actions: Disperses internal stagnant heat (from Qi stagnation); clears heat; eliminates toxicity; can separate a mixture of Yang pathogenic factors.

Indications:
• Wind-heat or early stage attack of warm-heat pathogen: fever, headache, thirst, sore throat, slight chills.
• Heat and toxicity: various kinds of carbuncles, nodules, boils, lymph swellings, all hot sores.
• Some benefit in acute nephritis and macular hemorrhage.
• May possess antiemetic properties.
• Doctrine of signatures: resembles the heart and, like the heart, it is light when open.
• Broad spectrum antimicrobial like Jin yin hua. Lian qiao is better against Shigella and Staphylococcus aureus, while Jin yin hua is better against Salmonella and hemolytic Streptococcus.
HF: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas.
Hsu: Antiviral, cardiotonic, diuretic.
DY: Clears heat from the whole body; clears the heart and upper burner fire; treats skin inflammations; scatters nodulation and disperses swelling.
• Do not exceed 15g/day – can damage the stomach Yang (sometimes 30g per day can be tolerated for a short time).
• With Jin yin hua to strongly and effectively clear heat and resolve toxins. See Jin yin hua above for specific indications of this combination.
Lian qiao is superior to Jin yin hua for clearing heat-toxicity, but (unlike Jin yin hua) Lian qiao does not reinforce the expelling actions of herbs which disperse wind-heat.

Dose: 6-15g
Two types of Lian qiao: (B&G, DY)
• Qing lian qiao or Qing qiao: the blue-green fruit which has just begun to ripen. It is superior for clearing heat, resolving toxins, and treating warm diseases, fever, and erysipelas.
Huang lian qiao or Lao qiao: the ripe, yellow fruit – called “Old” qiao. It is superior for dispersing abscesses and swelling, scattering nodulation, and treating goiter, subcutaneous nodules, skin inflammations, and carbuncles.
Lian Qiao Xin: the seed
• Clears heat-toxicity which have entered the pericardium causing vexation, agitation, irritability, insomnia, high fever with delirium, mental confusion, loss of consciousness.

Ma Bo – Lasiosphaera or Calvatia – Puffball mushroom

Nature: acrid, neutral

Enters: Lung

Actions: Eases the throat; stops bleeding; clears Lung heat; disperses wind-heat.

Indications:
• Lung heat: swollen, painful throat, cough, aphonia; hemoptysis, epistaxis.
• Topical: for bleeding (most often in the oral cavity and lips), sores, wounds, epistaxis. Also for bleeding gums associated with frostbite.
• For hemorrhage from surgery (prostate, liver, spleen, kidneys) and trauma. In one series of 467 cases, it was successful 98% of the time.
• Can easily induce sweating and vomiting in its unprepared form. The herb should be honey-fried except when used to stop bleeding.
• Large doses can induce nausea.
• Possesses antimicrobial properties.
• Wrap in cheesecloth or a tea bag while cooking.
Hsu: Antiphlogistic, antipyretic, astringent.

Dose: 1.5-4.5g

Ma Chi Xian – Purslane – Portulaca – “Horse’s Teeth Amaranth”

Nature: sour, cold

Enters: Large Intestine, Liver

Actions: Relieves fire toxicity; cools the blood; clears damp-heat; treats sores; antidotes wasp and snake poison.

Indications:
• Damp-heat or fire toxicity: dysenteric disorders; hot or bloody painful urinary dysfunction. In clinical studies involving thousands of subjects, decoctions of Ma chi xian reduced the incidence of bacillary dysentery in those exposed during epidemics. The herb is about as effective as sulfa drugs in treating acute and recurrent bacillary dysentery – over 90% effective in acute cases and less than 60% effective in chronic cases.
• Carbuncles, sores, red-and-white vaginal discharge. Applied topically or taken internally.
• Wasp stings, snake bites: for pain and swelling.
• Recently used for post-partum bleeding.
• Hookworm: when juice or tablets of Ma chi xian were taken by 192 subjects, 80% had a negative stool sample in one month.
• Appendicitis: A decoction of Ma chi xian and Pu gong ying was used in treating 31 cases of clinically diagnosed appendicitis. Of these, only one needed surgery; all others recovered uneventfully.
• Contractile effect on the uterus.
• Often prepared as a wash for skin problems.

Dose: 15-60g (The fresh used is often used at double the dry dosage)

Niu Huang – Cow, Ox, or Water Buffalo Gallstone (Bezoar) – “Cattle Yellow”

Nature: bitter, cold

Enters: Liver, Heart

Actions: Clears the heart, strongly opens the orifices, awakens the Shen by resolving phlegm; extinguishes liver wind, relieves tremors; clears heat; eliminates toxicity.

Indications:
• Heat-toxicity: painful, red, swollen or ulcerated throat, canker sores, boils, carbuncles, ulcers, sores, herpes lesions, and a wide variety of hot swellings.
• Liver wind (due to extreme pathogenic heat): spasms, tremors, (infant) convulsions.
• Heat or phlegm-heat blocks the heart in wind-stroke or epilepsy: coma, difficulty speaking, delirium, seizures.
• Note: this herb should not be used alone for phlegm, as its cold nature may congeal the phlegm.
• Not as strong as She xiang at opening the orifices.
• The genuine article is expensive and difficult to find. The lab produced variety (Ren gong niu huang) is available, which is comparable to the true herb for treating heat-toxicity, but is weaker than the true herb at opening the orifices.
• Bensky/Gamble classifies with herbs that open the orifices.
MLT: Due to its rarity and expense, it is mostly used in the patent Niu Huang Jie Du Pian.
• With rhinoceros or water buffalo horn: for legionnaire’s disease, meningitis, encephalitis.
Hsu: Sedative to the CNS, respiratory, and circulatory systems; cardiotonic; raises blood pressure; stimulates RBC and hemoglobin production.

Dose: 0.15-1g (used only in pills and powders)

Pu Gong Ying – Taraxacum – Dandelion

Nature: sweet, bitter, cold

Enters: Liver, Stomach

Actions: Drains dampness; clears heat; eliminates toxicity; promotes lactation; reduces abscesses; dissipates nodules.

Indications:
• Heat-toxicity: inflammation – mastitis, appendicitis, prostatitis; carbuncles, boils, abscesses, nodules (especially when firm and hard). Used internally and topically.
• Damp-heat: jaundice, painful urination.
• Insufficient lactation: especially when due to heat.
Pu gong ying clears heat without the risk of damaging the stomach.
• The leaves are better at draining dampness than the root. The root is generally regarded as better at eliminating toxicity than the aerial parts.
• Antibacterial; anti-inflammatory.
K&R: Cholagogue, laxative, diuretic. Wood excess, metal deficiency, water excess.
• Wood: biliary dyskinesia, vesicular calculi, constipation, obesity, cellulitis, urea, gout, hypercholesterolemia, varices, acne, herpes, eczema.
Metal: acne, chronic rheumatism.
Water: excess uric acid, urinary calculi, urea, renal insufficiency.
• Also for various states of congestion of the liver and pancreas.
• Use as an eyewash for acute conjunctivitis.
Yoga: Bitter, sweet/cooling/pungent. P, K-; V+
• Alterative, diuretic, lithotriptic, laxative, bitter tonic.
• Detoxifies Pitta and Ama conditions.
• For swollen lymph nodes, tumors, suppressed lactation, breast problems.
• Similar to the Indian herb Bhringaraj – may substitute.
• Detoxifying for over-consumption of fat, fried foods, and meat.
MLT: For cirrhosis, hepatitis; all breast disorders.
• The whole herb is strongly diuretic, especially the leaves.
Joe: Rich in potassium. Therefore, when used as diuretic, it should not deplete potassium in the body.
RW: Rich in vitamins, especially C.
• Contains substances which act like enzymes, stimulating the function of the large glands – especially the liver and kidneys – and stimulating cell metabolism as a whole.
• Diuretic and cholagogue: encourages kidney function and promotes secretory function in the liver. Good for gall and kidney stones.
• For a tendency to form gallstones: must take dandelion for 4-6 weeks (best done in the spring, and repeated in the fall if necessary).
• One of the best herbs to use in chronic rheumatic complaints, chronic degenerative joint disease, and arthritis (requires repeated, consistent courses of treatment).
MW: The root focuses more on the (Western) liver – for stagnant metabolism, waste products/fluids building up. The leaf focuses more on the (Western) kidneys.
• Will stop infections in bones (e.g., infected tooth and jaw).
• Good when the tongue has a geographic coat.
• For mental illness: manic depression, obsessive-compulsive disorders (generally takes time to work – 6-12 weeks – not usually for acute disease).

Dose: 9-30g (up to 100g fresh)

Qin Pi – Fraxinus branch bark – Korean Ash

Nature: bitter, cold

Enter: Liver, Gallbladder, Large Intestine

Actions: Clears heat, drains liver fire; drains dampness; disperses wind-dampness; eliminates toxicity; benefits the eyes.

Indications:
• Stagnant liver heat: red, swollen, painful eyes or superficial visual obstruction.
• Damp-heat or large intestine heat and toxicity: dysentery (not amebic) with pus and blood.
• Wind-dampness: Bi syndrome, mainly hot.
• Bensky/Gamble classifies Qin pi with herbs that clear heat and dry dampness.
Hsu: Antiphlogistic; analgesic; suppresses arthritis; diuretic.

Dose: 4.5-15g
Excelsior species: Similarity to Qin pi (Fraxinus rhynchophylla, F. bungeana, F. chinensis) unknown. However, studies done in Russia would seem to indicate that Eastern species possess the same (or similar) properties as Western species.
K&R: (Ash – F. excelsior) Laxative, purgative, febrifuge, astringent.
• Moves the bowels, relieves the pain of constipation.
• Stimulates sluggish metabolism, stimulates secretions of the Islets of Langerhans.
• In Russia it is used as a circulatory stimulant to warm the hands and feet (warms the entire body).
• For intermittent fevers. Once used in place of quinine for malaria.
• Uremia (Cheynes-Stokes), arteriosclerosis, hypercholesterolemia.
• Metal, water, fire, and earth excess:
Metal: arterial hypertension, arteriosclerosis, hypercholesterolemia, uremia.
Fire: urinary calculi, gout, rheumatism.
Water: oliguria, urinary calculi, hypertension, arteriosclerosis, promotes longevity.
Earth: arthritis, arteriosclerosis, rheumatism, stimulates sluggish lymph.

Qing Dai – Indigo – A preparation of Shi Gao and Da Qing Ye

Nature: salty, cold

Enters: Liver, Stomach, Lung

Actions: Cools the blood; relieves swelling; clears heat; eliminates toxicity.

Indications:
Heat or heat and toxicity in the blood: epistaxis, hemoptysis, hematemesis.
Heat and toxicity in the liver: infant convulsions, fever.
Heat in the Lungs: cough, sticky sputum, difficulty breathing.
Heat and toxicity: mumps, carbuncles, acne. Used both internally and topically.
Topical: inflammation of oral cavity and throat (often combined with Bing pian).
One component (Dian yu hong) is effective for treating leukemia, raises RBC count, decreases abnormal cells.

Dose: 1.5-3g directly in pills or powders (to 9g or more when cooked)

Shan Dou Gen – Sophora root (S. tonkineenis or S. subprostata) – “Mountain Bean Root”

Nature: bitter, cold

Enters: Lung, Large Intestine

Actions: Benefits the throat; relieves swelling, alleviates pain; clears heat; eliminates toxicity.

Indications:
• Heat and toxicity: swollen, sore, painful throat; carbuncles, psoriasis. A key herb for sore throat due to heat and toxicity.
• Lung heat: cough.
• Damp-heat: jaundice.
• Topical: use the powder for pain, redness, and swelling of the oral cavity or cervix.
• Anti-neoplastic effects.
• Doses over 10g may cause nausea and/or vomiting.
Hsu: Anti-cancerous effects against malignant carcinomas; antimicrobial.
DY: Shan dou gen is the most efficient Chinese medicinal for treating throat inflammations due to heat-toxins or replete heat.
• With Ban lan gen for mutual reinforcement, to clear heat, eliminate toxicity, and strongly disinhibit the throat. For such indications as:
– 1. Painful, red, and swollen throat due to replete heat. This combination is usually sufficient to treat severe throat inflammations (including strep throat, tonsillitis, pharyngitis, laryngitis, etc.) due to heat-toxins or replete heat. However, when this combination needs further reinforcement, add She gan, Jin yin hua, Lian qiao, Xuan shen, and Gan cao.
– 2. Toothache and painful, swollen gums due to replete heat.
– 3. Oral ulcers due to replete heat.

Dose: 3-9g

She Gan – Belamcanda rhizome – “Arrow Shaft”

Nature: bitter, cold

Enters: Lung

Actions: Powerfully eliminates phlegm; eases the throat; clears heat; eliminates toxicity.

Indications:
• Phlegm-heat or fire excess or fire-toxicity: swollen, painful throat. Sometimes used alone for sore throat.
• Phlegm accumulation: cough, asthma, wheezing.
She gan’s powerful ability to eliminate phlegm makes it valuable for cold- phlegm patterns also, for which it should be combined with warm herbs.
• May be useful for uterine fibroids.
• Increases secretion of saliva.
• Liu: Not recommended for treating wind-heat. Since it is bitter, not acrid, it may drive the pathogen to the interior.
• The exquisite cultivated flower of this plant is sometimes called Blackberry Lily or Leopard flower.
MLT: Anti-hyaluronidase activity, especially useful to control inflammation; topical: for sores, dermatitis.
Gargle: with a little salt and lemon juice in water for severe sore throat.
Hsu: Antifungal, hypotensive.

Dose: 1.5-9g

Tu Fu Ling – Smilax – Sarsaparilla

Nature: sweet, bland, neutral

Enters: Liver, Stomach

Actions: Clears heat; eliminates toxicity; resolves dampness; relieves joint pain and muscle spasm.

Indications:
• Damp-heat (including with toxicity): joint pain, turbid and painful urination, jaundice, genital problems (liver channel).
• Dampness and toxicity: skin problems including acne, carbuncles, boils, herpes.
• Syphilis: pain and spasms of the muscles around joints (use with Jin yin hua and Wei ling xian)
• Lupus.
• Lyme disease.
• Treats and prevents leptospirosis.
SD: May help antidote arsenic and mercury poisoning.
K&R: Depurative, diuretic, stimulates LH secretion.
• Water excess, metal deficiency.
Water: nephritis, edema, gout, arthritis, rheumatism.
Metal: skin problems, flatulence; mild diaphoretic.
• Also for leukorrhea with inguinal lymphatic swelling.
• Eliminates urea for uremia; psoriasis.
• Contains hormone precursors.
• Traditionally used as a tonic.
BII: Binds to gut endotoxins for conditions associated with high levels of toxins: psoriasis, eczema, arthritis, ulcerative colitis.
• Possibly beneficial in cancer treatment.
Hall: For reproductive hypofunction, difficulty conceiving/sterility.
• May eliminate the inherited traces of unresolved disease (particularly syphilis).
• Teenage acne.
Yoga: Dwipautra: P, V- (does not increase Kapha)
• Alterative, diuretic, diaphoretic, antispasmodic, antisyphilitic, anti-rheumatic.
• Purifies the genitourinary tract – dispels infection and inflammation.
• Purifies the blood, improves Agni.
• Helps dispel accumulated Vata from the intestines.
• Cleanses the mind of negative emotions, useful in many nervous disorders.
• Tonic action on the sexual organs.
• Topical: As a wash for genital sores or herpes.
• Use as a hot fomentation for painful, arthritic joints.
MLT: Lymph cleanser.
• Able to penetrate the blood-brain-barrier: useful for spirochete-type microbes – syphilis, Lyme disease.
• Also useful for herpes.
JC: Alterative, diuretic, tonic, stimulant, relaxant, demulcent, diaphoretic, cathartic, anti-arthritic, anti-syphilitic, depurant, deobstruent, anti-scorbutic, carminative, poison antidote.
Hsu: Anti-tumor effect – use 500-750g.

Dose: 15-60g

Ya Dan Zi – Brucea fruit – “Crow Gallbladder Seed”

Nature: bitter, cold, toxic

Enters: Large Intestine, Liver

Actions: Treats dysenteric disorders; treats intermittent fever and chills; topically treats corns and warts.

Indications:
• Topical: for warts and corns. For warts, the wart can be seen as a parasite and Ya dan zi as an antiparasitic herb which feeds the parasite and then kills it. Ya dan zi is broken open and the white seed inside is applied to the wart. Usually requires continuous application for at least 10 days. For the first 10 days, nothing may appear to be happening. By 14 days, the wart should suddenly be gone.
• Chronic or recurring dysenteric disorders. An important herb for chronic cold stagnation dysenteric disorders that wax and wane, or alternating hard and soft stool. Particularly useful for dysentery due to protozoa.
• Malarial disorders: alternating fever and chills. Yan dan zi’s antimalarial effect is stronger than that of Chang shan and equal to quinine. In experiments the dosage required for an antimalarial effect was quite high and side effects of nausea and vomiting sometimes occurred.
• Generalized inhibitory effect on the CNS.
• Kills Entamoeba histolytica and the malarial parasite, but has no effect against Shigella or Salmonella. The herb has a success rate from 72-94% against amebic dysentery with a recurrence rate of approximately 6%.
• Antiparasitic against a number of intestinal parasites.
• Extremely bitter taste, stimulates the stomach to the point that it may cause nausea, pain, and diarrhea. It is therefore not used in decoctions. It is either placed in capsules or inside Long yan rou.

Dose: 10-15g for malarial disorders; 10-30g for dysenteric disorders

Ye Ju Hua – Wild Chrysanthemum flower

Nature: acrid, bitter, slightly cold

Enters: Lung, Liver

Actions: Drains fire; relieves toxicity.

Indications:
• Heat and toxicity: furuncles, carbuncles, sores, sore swollen throat.
• Wind-fire: red eyes.
• Topical: for chronic cervicitis.
• Hypertension: used either alone as an infusion or with Pu gong ying and Jin yin hua in a decoction.
• Antibiotic effects.
• Lowers blood pressure: the flower alone is less toxic and more effective than the entire plant.
• Helps prevent common cold.
• In patients with acute bronchitis, Ye ju hua reduces the number of acute attacks.
MLT: More detoxifying than Ju hua.
• Use internally or externally for all inflammations.
• Compared to Ju Hua, this flower is tiny.
• May be very similar to (Western) Feverfew.

Dose: 6-15g

Yu Xing Cao – Houttuynia – “Fishy-Smelling Herb”

Nature: acrid, slightly cold

Enters: Lung, Large Intestine

Actions: Drains pus; clears heat; eliminates toxicity; reduces swelling and abscesses; drains damp-heat, promotes urination.

Indications:
• Heat and toxicity in the Lungs: cough with sticky sputum, including extreme Lung phlegm-heat with green phlegm or Lung abscess with pus and blood. A key herb for Lung abscess. Also for bacterial pneumonia, COPD, bronchitis.
• Damp-heat: painful, burning urination, colitis, diarrhea.
• Heat and toxicity: carbuncles, sores, pus. Used internally or topically.
• Topical: for skin problems, especially herpes.
• Cook with sesame oil and soy sauce and eat to promote digestion, improve the appetite.
• Antimicrobial.
• Should not be cooked long.
MLT: Good for treating the adverse effects of tobacco addiction. Use in a formula with Ren shen, Sang bai pi, Gua lou, Jie geng: take two 00 capsules of this powdered mixture every 1-2 hours to lessen cravings, and support detoxification. Lower the dose after 3-4 days.
Hsu: Strengthens capillary walls; antifungal, antibacterial, antiviral, diuretic.

Dose: 15-60g

Zao Xiu – Qi Ye Yi Shi Hua – Chong Lou – Paris Rhizome

Nature: bitter, slightly cold

Enters: Liver

Actions: Clears heat; eliminates toxicity; relieves swelling and pain; subdues liver wind to relieve convulsions; mildly moves blood.

Indications:
• Heat and toxicity: snake bite, carbuncles, boils, acne.
• General herb for any kind of pain.
• Liver wind stirring: epilepsy, convulsions.
• Warm-heat pathogen: coma, convulsions.
• Blood stasis: pain after trauma (inferior to San qi for this).
• Particularly good for early stages of heat and toxicity.
DuiYaoOnline.com:
• Phlebitis: zao xiu mixed with vinegar was grounded to get the juice which was applied to affected areas of phlebitis caused by injection of various anti-cancer drugs. 30 cases were treated and the effect was satisfactory.
• Uterine bleeding: zao xiu was grounded into raw powder, made into dry powder and capsulated. Each capsule contains 2g crude drug. It could be used to treat dysfunctional uterine bleeding, menorrhagia due to uterine fibroids or pelvic inflammation.
• Chronic bronchitis: zao xiu was made into tablets, 3g, bid after meals, 10 days as a course of treatment, 3 courses totally. It had satisfactory effect on chronic bronchitis.
• Chronic hepatitis B: zao xiu, wu wei zi, guan zhong, nu zhen zi, ku shen, etc., 1 dose daily, 2 months as a course of treatment. The total effective rate was 92.8%.
• Acute infections of bile system: zao xiu, bai hua she she cao, ban bian lian, jin qian cao, dan shen, 30g each; zhi shi 20g; huang lian 10g; sheng da huang 6g, with jaundice, add yin chen. The control group was treated with intravenous drip of antibiotics. Results: all indices in the treated group were significantly supeior to those of the control group.
• Stomach cancer: zao xiu 50~100g, other formula based on TCM differentiation could be combined, water decoction, 10 days as a course of treatment, 7~8 courses totally. 15 cases of stomach cancer in late stage with wide metastasis were treated, 11 cases survived more than 1 year, 4 cases more than 2 years.
• Vulvitis: zao xiu, tu fu ling, ku shen, 90g, huang bo, da huang, 45g each; long dan cao, bi xie 30g each; ku fan 15g. 1 dose daily, water decoction. The juice was used to steam and wash the private parts, tid, 30 minutes daily, 56 treated cases were all cured.

Dose: 5-10g

Notes on this Category

• Because the herbs in this category are quite cold and bitter, use them with caution in cases of body fluid injury or deficiency of the spleen and/or stomach.
• Herbs in this category are commonly combined with:
A. Herbs that strengthen the spleen and stomach, when there is deficiency of these organs.
B. Herbs that nourish Yin, when there is injury of body fluids by heat or the patient has pre-existing Yin deficiency.
C. Herbs that clear heat and reduce fire, when there is fire.
D. Herbs that clear heat and eliminate toxicity, when there is toxicity.

In general, these herbs are related to or bear close resemblance to the class of herbs that in Western herbalism are called “bitter tonics.” This use of the word “tonic” is somewhat different from the Chinese concept of a tonic. These herbs are considered tonics because they are useful for atonic conditions of membranes, muscles, and other tissues – particularly of the gastrointestinal tract. Also, based on the doctrine of signatures, yellow herbs are said to be useful for yellow conditions (e.g. thick yellow tongue coat indicating damp-heat, the yellowness of jaundice indicating [yang-type] damp-heat, yellow phlegm), and to affect organs that process yellow fluids – urine and bile (i.e. the biliary tract and urinary tract). For these purposes (mainly digestive weakness) they are prescribed in much smaller doses than those given in Chinese herbalism for clearing damp-heat. Typical doses of the bitters are a few drops of tincture in water (up to about 60 drops), three times daily, which might be equivalent to something from 0.02g to a maximum of 1.5 g of the herb daily. When using these herbs in the Chinese doses given below, they may be wisely combined with protective/restorative supplements (e.g., warming herbs such as sheng jiang; moderating herbs such as gan cao, da zao; middle jiao rectifying herbs such as chen pi, mu xiang; spleen Qi tonics; probiotics; l-glutamine; zinc-carnosine; etc.) when appropriate.

Also consider to clear Damp-Heat, when appropriate: Bai hua she she cao, bai tou weng, bai xian pi, ban lan gen, chuan xin lian, jin yin hua, ma chi xian, pu gong ying, shan dou gen, tu fu ling, yu xing cao, hu huang lian, qin jiao, xi xian cao, pei lan, bi xie, bian xu, che qian zi, chi xiao dou, deng xin cao, di fu zi, dong gua ren, dong kui zi, hai jin sha, hua shi, jin qian cao, mu tong, qu mai, shi wei, tong cao, yi yi ren, yin chen hao, ze xie, da huang, gan sui, qian niu zi, chuan lian zi, mu xiang, hu zhang, niu xi, si gua lou, yi mu cao, chun gen pi, bai mao gen, di yu, huai hua, etc.

See also herbs that also clear heat in the Drain Damp category, Cool Herbs that Resolve Phlegm category, etc.

The first three herbs in this category, plus Zhi zi comprise the formula Huang Lian Jie Du Tang.

Huang Bai – Phellodendron bark – Amur Cork tree – “Yellow Fir”

Nature: bitter, cold

Enters: Kidney, Bladder, Large Intestine

Actions: Clears heat and dries dampness (particularly from the lower Jiao); reduces fire; eliminates toxicity; clears deficiency heat; lowers blood pressure

Indications:
• Damp-heat (especially in the lower Jiao): painful urination, low back pain, thick yellow leukorrhea, foul-smelling diarrhea, dysenteric disorders, prostatitis, red, swollen and painful legs, feet, knees, or jaundice.
• Yin deficiency heat: tidal fever, night sweats, spermatorrhea, steaming bone disorder, afternoon fever.
• Damp-heat-toxicity: carbuncles, boils, sores, lesions, eczema. Can also be used as a wash, powder, or ointment.
• Useful in meningitis.
• Bacillary dysentery.
• Topical: vaginitis and cervicitis from Trichomonas infection.
• Conjunctivitis.
• Weak antibiotic: contains berberine ∼1% or more (less than Huang lian).
Li Dong Yuan: Leads rising Yang Qi back down to its lower source.
MLT: Useful for kidney fire with nocturnal emissions, insatiable sexual urges.
Hsu: Antiphlogistic, anti-inflammatory.
DY: With Zhi mu to clear heat, enrich Yin, drain deficiency fire, resolve toxins, and eliminate dampness in the lower burner. For such indications as:
– 1. Evening fever, steaming bones, and night sweats caused by Yin deficiency.
– 2. Seminal emission, premature ejaculation, easy erection, excessive thinking about sex, sexual hyperexcitability, erotic dreams, nymphomania due to deficiency fire and hyperactive ministerial fire.
– 3. Dysuria due to Yin deficiency and to Yang losing its ability to transform (at the level of the bladder). For all these indications, both herbs should be salt mix-fried to guide their action toward the lower burner and kidneys.
• With Cang zhu for mutual reinforcement, to clear heat, dry dampness, disperse swelling, and stop pain. For indications such as:
– 1. Wilting of the lower extremities with pain in the sinews and bones due to damp-heat pouring downward. (Er Miao San) Use salt mix-fried Huang bai.
– 2. Abnormal vaginal discharge, external vaginal itching, and cloudy, scanty urination due to damp-heat. (Use Cang zhu which has been stir-fried until scorched.)
– 3. Red, swollen, hot, painful joints due to wind, damp, heat impediment. (Cang Zhu San)
• With Ze xie to clear and drain fire due to Yin deficiency, and clear and eliminate dampness and heat. For indications such as:
– 1. Steaming bones, night sweats, and seminal emission due to deficiency fire. (Zhi Bai Di Huang Wan) Both herbs should be salt mix-fried.
– 2. Inhibited urination and pricking, painful urination due to damp-heat in the lower burner. (Salt mix-fried Huang bai and either unprepared or salt mix-fried Ze xie should be used.)

Dose: 3-12g

Huang Lian – Coptis rhizome – Gold thread – “Yellow Links”

Nature: bitter, cold

Enters: Heart, Liver, Large Intestine, Stomach, Spleen

Actions: Clears heat; dries dampness; reduces fire; eliminates toxicity; clears heart fire, drains stomach and liver fire; adjusts the appetite; stops bleeding due to heat.

Indications:
• Heart fire: irritability, insomnia, high fever, restlessness, coma, delirium. Also combined with Rou gui for heart/kidney disharmony.
• Stomach or large intestine damp-heat: diarrhea, dysentery, vomiting, acid regurgitation.
• Stomach fire: digestive dysfunction, belching with a putrid odor, excessive hunger and thirst, diabetes. Also with Wu zhu yu in Zuo Jin Wan.
• Heat in the blood: epistaxis, hematuria, hemafecia, hematemesis.
• Heat and toxicity: carbuncles, boils
• Topical: for red and painful eyes; ulcerations of the mouth and throat; first and second degree burns; exudative erythema multiforme. Often used as a powder or ointment.
• Cholagogue; lowers serum cholesterol in rats; anti-inflammatory.
• Sometimes thought of, among the three “Huang” herbs in this category, as the main herb for addressing the middle Jiao, though it actually treats all three.
• For heart heat, Huang lian treats the heart, its mother (wood-liver), and also its son (earth-stomach/spleen).
• Contains berberine (4.7%): a broad spectrum antibiotic and fungicide. More effective than sulfa drugs. As effective as synthetic antibiotics for bacillary dysentery, tuberculosis, scarlet fever, diphtheria.
• Canker sores.
• Ulcerative colitis.
• Vaginal trichomonas infection.
• Tuberculosis.
• Typhoid fever.
• Scarlet fever.
• Diphtheria.
• Suppurative otitis media (administer in ear drops).
• Conjunctivitis, superficial keratitis.
• Anal fissures. (Applied repeatedly with cotton balls and increasing pressure.)
• Dry-fry it (Chao huang lian) to make it less cold and to help it enter the blood.
• Ginger-fry it (Jiang huang lian) to make it less cold, easier on the spleen and stomach, to treat stomach heat, help stomach Qi descend, and stop vomiting.
• Fry it with Wu zhu yu (Yu huang lian) to treat damp-heat in the Qi level, with such symptoms as diarrhea, vomiting, belching.
MLT: Combine Huang lian with any guiding herb to clear heat anywhere in the body.
• For diarrhea with stomach heat and an inability to ingest food, combine with Ren shen in a tea and sip throughout the day (it is alright if the patient vomits).
• With Huang bai, Huang qin, Da huang (4 yellows) for cancer.
PFGC: For heat in the upper Jiao: meningitis, cerebral hemorrhage, occasional dizziness, eye diseases with swelling and pain, canthus outcrop creeping over the eye (not for nebulous eye screen), bright red and rapidly spreading erisypelas.
• Damp-heat stagnating below the heart causing epigastric discomfort and fullness.
• Damp-heat: inflammations and ulcerations in the vagina.
• Contains the nutritive essence of fire and the functional nature of water – can resolve disorders that involve a chaotic interaction between fire and water: damp-heat in all three Jiaos.
• For eye disorders, coptis tea can be applied to the eyes with a cotton ball until the patient feels a bitter sensation in the throat.
• For red, swollen, painful eyes, coptis can be ground and mixed with sesame oil. The patient should then sniff its scent.
Hsu: Same antibiotic efficacy as sulfa drugs; stimulates gastric secretions (including from the pancreas); inhibits gastric ulcer formation; anti-inflammatory.
DY: Thickens the intestines, stops diarrhea; cools the blood; clears heat generated by dampness; treats vomiting and acid regurgitation caused by liver-stomach disharmony.
• The patient can take Huang lian with a slice of ginger on the tongue or eat ginger after taking it, if he or she is very sensitive to the bitterness. The herb can also be ginger-processed, wine-processed, or stir-fried until yellow to alleviate its bitterness.
• With Ban xia to harmonize upbearing and downbearing, Yin and Yang, to clear heat, dry dampness, transform phlegm, and stop vomiting. For indications such as nausea, vomiting, chest and epigastric fullness and distention, thick, yellow phlegm, yellow, slimy tongue fur, and a wiry, slippery pulse due to damp-heat, turbid phlegm, and/or mixed cold and heat causing stomach disharmony. Huang Lian Tang is typically used. For these indications, ginger-processed Ban xia and ginger mix-fried Huang lian should be used.
• With Gan jiang to eliminate cold accumulation and depressive heat, drain mixed cold and heat, in order to stop vomiting and diarrhea. The pair allows one to regulate upbearing and downbearing, to harmonize Yin and Yang, and to treat mixed cold and heat. The ratio of the two herbs can be adjusted (3-10g each) depending on whether heat or cold is predominant (use equal doses if heat and cold exist in equal proportion). For indications such as:
– 1. Vomiting, acid regurgitation, belching, epigastric pain or distention, and clamoring stomach (a feeling of hunger, burning, emptiness, unease, and sometimes pain in the stomach with nausea and acid regurgitation) due to a mixture of cold and heat in the stomach. (Ban Xia Xie Xin Tang) Use stir-fried Huang lian unless heat is severe.
– 2. Diarrhea, dysentery, and stomach rumbling due to mixed heat and cold and/or disharmony between the stomach and intestines. (Use stir-fried Huang lian unless heat is severe.)
– 3. Glossitis, stomatitis, and chronic, recalcitrant mouth ulcers due to spleen Yang deficiency and stomach fire.
• With E jiao to drain fire and enrich Yin according to the method of draining the south (i.e. fire) and supplementing the north (i.e. water), reestablish the interaction between the heart and kidneys, quiet the spirit, and treat dysentery damaging Yin. For indications such as:
– 1. Vexation, agitation, and insomnia due to febrile disease which has damaged Yin, deficiency fire, or heart and kidneys not communicating. (Huang Lian E Jiao Tang) Unprepared, or, even better, wine-processed Huang lian should be used.
– 2. Dysentery which damages Yin with pus and blood in the stools due to damp-heat in the large intestine.
– This is a key pair for heart-kidney disharmony, with symptoms mentioned above, plus many psychological disorders, loss of memory, profuse dreams, and tendency to wake up easily and frequently
• With Huang qin to effectively clear heat and dry dampness, drain fire, and resolve toxins from the upper, middle, and lower burners. For indications such as:
– 1. Red, swollen, painful eyes, toothache with red, swollen gums, oral ulcers, and glossitis due to full heat in the upper and middle burners. (Xie Xin Tang) Both herbs should be wine mix-fried. (The alcohol directs the action of these two herbs toward the upper burner.)
– 2. Vexation and agitation in warm disease with full heat or due to a breakdown in communication between the heart and kidneys. (Huang Lian Jie Du Tang or Huang Lian E Jiao Tang)
– 3. Diarrhea and dysentery due to damp-heat. (Shao Yao Tang)
– 4. Hematemesis and epistaxis due to heat in the blood. (Xie Xin Tang) Both herbs should be wine mix-fried.
• With Mu xiang to rectify the Qi, drain heat, dry dampness, and treat dysentery. This combination is used in Xiang Lian Wan for indications such as diarrhea, bloody and purulent dysentery, abdominal pain, and tenesmus due to damp-heat and Qi stagnation in the large intestine. Roasted Mu xiang should be used.
• With Rou gui (3-6g each) to harmonize Yin and Yang, drain the south (heart fire) and supplement the north (kidney Yang), and re-establish the interaction between the heart and kidneys. For indications such as:
– 1. Insomnia, vexation, and agitation due to heart and kidneys not communicating. (Such as for kidney Yang deficiency which cannot move and upbear kidney water, which then becomes dead and stagnant, and fails to nourish heart Yin and control heart fire which rises upward. Use Jiao Tai Wan.)
– 2. Glossitis, oral ulcers, heart palpitations, together with fear of cold, copious clear urination, impotence, and seminal emission due to simultaneous heart fire and kidney Yang deficiency.
• With Wu zhu yu to effectively drain liver fire, harmonize the stomach, downbear counterflow, and stop pain, acid regurgitation, and vomiting. For indications such as:
– 1. Lateral costal pain and distention, nausea, vomiting, acid regurgitation, belching, clamoring stomach, and a bitter taste in the mouth due to liver depression transforming into fire which disturbs the stomach. (Zuo Jin WanHuang lian:Wu zhu yu :: 6:1)
– 2. Diarrhea and dysentery due to damp-heat.
– The usual dosage for this pair is 3-10g Huang lian and 2-5g Wu zhu yu. Traditionally, the combination is for liver fire causing liver-stomach disharmony which, in turn, leads to nausea, vomiting, and acid regurgitation. In this case Huang lian should be prescribed in a larger quantity and Wu zhu yu in a lesser amount. However, this pair can also be used in patterns where cold and heat are mixed. In this case, if heat is predominant, the dosage of Huang lian should be proportionately more. If there is concomitant stomach Yin deficiency, add Shi hu. If cold is predominant, the dosage of Wu zhu yu should be proportionately more. If there is concomitant Qi deficiency, add Dang shen. If cold and heat are present in identical proportions, the quantities of both herbs should be equal.
• With Zi su (the leaves [Zi su ye] and stems [Zi su geng] of Perilla) to clear stomach heat, dry dampness, rectify the Qi, and stop vomiting. For the following indications, ginger mix-fried Huang lian should be used:
– 1. Vomiting and nausea due to stomach heat or damp-heat in the middle burner along with Qi stagnation in the middle burner.
– 2. Vomiting during pregnancy due to heat or damp-heat along with Qi stagnation in the middle burner.
Huang lian is incompatible with pork or cold water.
• From Michael Moore (via internet): Goldthread (coptis), in my opinion, is possibly the queen of remedies for stomatitis and slowly healing mouth sores (Myrrh and Anemopsis being preferable for acute problems). If you ever get a chance to gather some, be sure to use the leaves and stems as well… all parts of the plant are active. The constant reference to Goldthread Roots is a clumsy remnant of the crude drug trade of a century ago… the dried roots could be stored in burlap bags for a DECADE, the foliage lasted but a year or two. With drastic loss of wild places in the last century, we need to revamp our often wasteful use of herbs, gathered according to standards set in greener (and profligate) times.
Huang Huang: Huang Lian Family Formula
I. Introduction
A. Very bitter, and the taste lasts on the tongue, it will turn water yellow, and the tongue becomes yellow.
B. Western medicine has recently found that taking Huang Lian Su (an extract of Huang Lian) for a long time helps memory. In experiments it helps rats navigate mazes, and protects their brains (but not from scientists dissecting them).
C. This is superior class herbs, it protects the body, promotes life, good for long term use. D. Some think of it as antibiotic, but its function is to relieve irritability. Ex. Huang Lian E Jiao Tang for heart vexation and insomnia. In this formula one may use from 12-60g (depending on what original dosages really were.)
E . Vexation = insomnia and anxiety. [See power point picture.] One needn’t use He Huan Pi, Suan Zao Ren, etc., just use Huang Lian.
F. One commonly uses Huang Lian with warm or hot herbs. For diarrhea that is not foul swelling with Gan Jiang, for xin discomfort with Ban Xia, with Zi Su Ye as an infusion for xin discomfort in the throat.
II. Historical Information
A. Shen Nong Ben Cao Jing: Huang Lian: governs heat qi, eye pain,
eye injury, lacrimation, it improves the eyesight, also used for intestinal problems, abdominal pain, diarrhea, genital swelling and pain in women
B. Used in 12 formulas in SHL and 7 in JGYL
III. Patterns: Huang Lian treats heart vexation, epigastric focal distention, and diarrhea. The Huang Lian pattern are these three together.
A. Heart vexation (Pattern 1)
1. Largest dosage is 4 liang in Huang Lian E Jiao Tang, “Shaoyin disease for 2-3 days or more, heart vexation and insomnia.”
2. An ancient fable speaks of “groundless fears.”
B. Epigastric Focal Distention (Pattern 2)
1. Simplest formula is Da Huang Huang Lian Xie Xin Tang with just 2 ingredients
2. “Epigastric focal distention that is soft when pressed, pulse floating in the guan position.”(154)
3. With Xie Xin Tang, the xin may be uncomfortable, but not very painful when pressed and not hard. Often goes with stomach problems, if there are stomach problems one may develop insomnia and vs. versa.
C. Diarrhea (Pattern 3)
1. Ge Gen Qin Lian Tang “When in a greater yáng disease [the condition is a] Cinnamon Twig Decoction pattern, but the physician precipitates, [causing] incessant diarrhea and a pulse that is skipping, it means that the exterior has not resolved; when [there is] panting and sweating, Kudzu, Ge Gen Qin Lian Tang governs.” (37)
2. Bai Tou Weng Tang “When [there is] heat diarrhea with rectal heaviness” (371) and “When [there is] diarrhea with a desire to drink water, this means that [there is] heat; [therefore] Bai Tou Weng Tang governs.” (373)
3. There any formulas with this for diarrhea from the time of the Shang Han Lun and later.
IV. Huang Lian Constitution
A. Greasy face, irritability and heat, chest oppression and palpitations, epigastric focal distention, diarrhea
B. Huang Lian tongue
1. Tongue is firm and old looking, red or dull red, fur is yellow, slimy, and thick
2. Tongue body is old in appearance and lacks luster
3. If tongue is pale red, tender, and enlarged, with a thin white fur or no fur, must be cautious about using Huang Lian.
4. The tongue is important. This information comes from later physicians. A child’s tongue is soft and tender…this is the opposite. Huang Lian is not commonly used for kids, especially large dosages. Kids’s tongues are sensitive to bitter. (see power point pictures) Huang Lian is also for a completely red tongue with no coat (Huang Lian E Jiao Tang). The lower picture pairs it with Gan Jiang, the lower part of the tongue has some white, and it is not so hard. The upper picture is a Huang Lian Jie Du Tang picture, more yellow in the tongue, and it is harder.
C. Huang Lian pulse
1. Pulse should be slippery and rapid or rapid and skipping. Slippery, like pearls on a dish, but also a rapid pulse is usually slippery. A skipping pulse is faster than a slippery pulse. Patients usually have faster heart rates, and Huang Lian can control the heart rate.
2. if the pulse is slow and the body cool, use caution with Huang Lian.
N.B.: Hot body type tending toward damp heat and heart fire
V. Dosage of Huang Lian
A. Zhang Zhong-Jing typically had two ways of dosing Huang Lian
1. A large doses to eliminate irritability (4 liang)
2. A small doses to eliminate focal distention (1 liang)
B. Dr. Huang: large dosage is 10-15; low dosage is 2-3g. A large dosage can cause stomach discomfort. Quite often he combines with Fu Zi, Gan Jiang, or Rou Gui. If he combines two formulas he uses dosage in middle range.
C. His colleague Tong Xiao Ling uses 30-60g. Treats diabetes without Western medicine.
D. Others use large amounts for fever in short term.
N.B.: If a patient needs Huang Lian the taste not bad, it is refreshing. It starts to taste bitter as they improve. One can often see the reaction of patient to herbs, if they like them or not, feel better or not.
VI. Huang Lian Formula Family
A. Huang Lian Tang
B. Xiao Xian Xiong Tang
C. Huang Lian E Jiao Tang
D. Huang Lian Jie Du Tang
E. Ge Gen Qin Lian Tang
F. Ban Xia Xie Xin Tang

Huang Lian Tang
I. Traditional Dosage
Huang Lian 3 liang
Gan Cao 3 liang
Gan Jiang 3 liang
Gui Zhi 3 liang
Ren Shen 2 liang
Ban Xia 1/2 sheng
Da Zao12 pc.
Cook herbs in 2000 ml down to 1200 ml. Take warm, three times in the day and twice in the night.
N.B.: Low dose, taken frequently. Original instructions are to take 3 doses during the day and 2 at night. May have been considering that the patient had nausea and vomiting, making large herb dosage more difficult.
II. Classical Presentation
A. When in cold damage, [there is] heat in the chest, evil qi in the stomach, pain in the abdomen, and a desire to vomit, Huang Lian Tang governs.(173)
B. Heat in the chest=chest oppression and irritability, palpitations, insomnia
C. Evil qi in the stomach=abdominal discomfort, abdominal pain, nausea and vomiting, intestinal rumbling
D. Hu Xi-Shu thought there was water qi in the stomach
E. Key indicators: Abdominal pain and desire to vomit:
F. Abdominal pain usually periumbilical and paroxysmal or stuffed feeling: this is a key indicator for use of Gui Zhi
E. Usually accompanied by diarrhea
III. Dr. Huang’s Dosages
Huang Lian 10g.
Gui Zhi 15g or
Rou Gui 10g
Dang Shen 10g.
Ban Xia 15g.
Gan Cao10g.
Gan Jiang 10g.
Da Zao 20g.
Dr. Huang’s dosage is in the middle range because there are both fan zao and digestion problems. Administration: need to take 5 times/day, 3 in day, and 2 at night, maybe because of the acute nature of the disease. Use either Gui Zhi or Rou Gui or both together. With Rou Gui one should use a lower dose. Using Rou Gui as a substitute for Gui Zhi has benefits: Rou Gui better able to relieve pain, warm the stomach, and settle palpitations. Dr. Xie comments: patient also has pain below umbilicus from intestines. Blood vessels contracted there?
IV. Constitution
A. Thin body
B. Dull pale tongue with thick white fur
C. Distinct digestive system symptoms, such as abdominal pain, nausea and vomiting, diarrhea, etc.
D. Generally accompanied by irritability, palpitations, insomnia
E. Dark complexion, tongue dark, dull, washed out
F. According to Xia Yi-Jun (Jiang Su), when using this formula, the tongue fur may be thick and white, especially on the back half of the tongue
V. Suitable Diseases
A. Gastric paresis secondary to diabetes
1. Common autonomic nervous system symptom associated with diabetes
2. Commonly manifests as chronic gastritis, poor stomach tone with food retention
3. Abdominal distention, easily full, poor appetite, belching, nausea, vomiting, weight loss, all worse after meals
4. Abdominal exam: distention and fullness and water sound
5. Reduced peristalsis, stomach dilation, delayed emptying, pylorus too open
6. Gastroscope: hyperemia of stomach mucosa, edema, erosion
7. For “things stuck in stomach,” it is particularly good for this.
8. Huang Lian and Rou Gui both decrease blood sugar, these two constitute the formula Jiao Tai Wan that quiets the spirit.
B. Food damage
1. On Dr. Huang’s website, report of a physician cooked Huang Lian Tang and sold it in the springtime as a “Western med” for gastritis
2. For people who eat irregularly, eat and drink large amounts suddenly
3. For children who overeat sweets and fatty rich foods, causing blockage with abdominal pain, diarrhea, nausea, vomiting (acute gastronenteritis)
4. Used original formula without any additions and without Western meds
5. Worked very well and sold like crazy!
C. Drunkenness
1. After getting drunk, can alleviate vomiting, diarrhea , dizziness
2. Clears the mind and GI distress, also clears bad breath.
3. Dr. Huang adds Ge Gen that overcomes alcohol poisoning and can clear mind. After drinking people get stiff neck, bent over, swollen tongue.
4. Flushing up of yang after drinking a little is a Huang Lian and Rou Gui problem, one can use it as a prophylactic.
D. Chronic gastritis, stomach ulcers
1. Commonly seen in thin patients with dark complexion and a tendency to diarrhea
2. Must have signs of heat in tongue or face, irritability and insomnia. Common and chronic in middle age men. Their complexion gets bad, tongue fur thick and slimy. This is especially seen in smoking men.
3. In clinic cold and hot are commonly mixed, especially in digestion disorders. One can use harmonizing formulas as well as San Huang Xie Xin Tang together with Si Ni Tang, etc.
E. Myocarditis, Tachycardia
1. This formula can bring the heart rate down.
F. Fevers in stomach-intestinal colds
Case History: Recurrent fevers
Dr. Huang observed Xia Yi-Jun treat a patient with recurrent fevers. After the fever, he would sweat and then get cold. Stool was unformed, root of the tongue had a thick white fur. Treated effectively with this formula
Case History: Intractable fevers
A man had fevers that would not go away after a stomach infection. He had this type of constitutional tongue. One must treat this type with Huang Lian and Rou Gui.
N.B.: One commonly uses Huang Lian with warm or hot herbs. So it is for this presentation. Also for diarrhea not foul swelling with Gan Jiang, for xin discomfort with Ban Xia. With Zi Su Ye as infusion for xin discomfort in throat.
G. Insomnia, Neurosis
1. Accompanied by diabetes or stomach pain and distention
2. Can use original formula
3. Can also use equal parts of Huang Lian and Rou Gui as an infusion before bed (2-3 mouthfuls can aid sleep)
VI. Compared with Xiao Chai Hu Tang
A. Xiao Chai Hu Tang for fevers, Huang Lian Tang for abdominal pain
B. Both formulas treat nausea and vomiting
C. Xiao Chai Hu Tang accompanied by fever, and fullness and discomfort in the chest and rib side area
D. Huang Lian Tang accompanied by lower abdominal pain, diarrhea, palpitations, irritability. It can bring down fevers.
E. Difference is upper and lower, inner and outer
VII. Compared with Ban Xia Xie Xin Tang treats
A. Ban Xia Xie Xin Tang epigastric focal distention
B. Huang Lian Tang treats abdominal pain with intestinal rumbling and diarrhea
C. Both treat disorders of the digestive system. The difference lies in stomach vs. intestines
D. Huang Lian in combination with Huang Qin was important to Zhang for epigastric distention.

Xiao Xian Xiong Tang
I. Traditional Dosage
Huang Lian 1 liang
Ban Xia 1/2 shen
Gua Lou Shi 1 large piece.
First cook Gua Lou in 6 sheng of water down to3 sheng. Add other herbs and cook down to 2 sheng. Take warm in 3 doses.
II. Classical Pattern
A. When in minor chest bind disease, [the location is] directly below the heart and painful when pressure is applied, and the pulse is floating and slippery, Xiao Xian Xiong Tang governs.(138)
B. Chest bind is ancient term from the Shang Han Lun.
1. Refers to evil qi bound in the chest.
2. Chest pain with hardness and fullness in the local area
3. Major and minor are differentiated on the basis of symptom severity
4. Minor: water and heat bound in the epigastrium, painful when pressed; floating slippery pulse
5. Major: excess heat bound from epigastrium down to lower abdomen, area is hard and full and cannot be touched; deep pulse
C. Epigastric is painful as well as uncomfortable, pulse slippery and rapid
III. Dr. Huang’s Dosages
Huang Lian 5g
Ban Xia 15g
Gua Lou Shi 30g
Rare to use without other herbs, Dr. Huang combines it with Xiao Chai Hu Tang (called Chai Xian Tang), or with Da Chai Hu Tang, he calls it (Xiao Xian Tang??)
IV. Constitution
A. Red face with oily luster
B. Rib-sides and upper abdomen resist pressure and may be painful
C. Cough, sticky yellow phlegm
D. Constipation
E. Red tongue with yellow slimy fur
F. Floating slippery pulse, may be flooding
G. Lots of sputum…important symptom. The type that “will stay on street for three days.” Constipation important
V. Suitable Diseases
A. Chest oppression, cough and wheezing
1. Bronchitis, asthma, bronchiectasis, pneumothorax
2. All with chest oppression and sticky yellow phlegm
3. Important: pain with lots of sticky yellow sputum. After a cold, it’s often like this. Dr. Huang combines it with Xiao Chai Hu Tang
4. Also for bronchial asthma, combine with Da Chai Hu Tang if there is constipation. Once it unblocks the bowels, sputum will decrease.
B. Chest pain
1. Hypertension, cardiac disease
2. Oily red complexion
3. Chest oppression
4. Constipation
5. Cough with copious phlegm
6. Corornary heat disease:, forgetful, SOB, often worry about BM and often constipated. May also have cough. Some use this for angina. Some use this instead of Dan Shen, Hong Hua, etc. This similar to chest bi formulas.
C. Abdominal pain
1. Gastritis, cholecystitis, pancreatitis, biliary reflux gastritis, acute and chronic gastritis,
pyloric obstruction
2. With symptoms of upper abdominal fullness, oppression, and pain with pressure
3. Accompanied by nausea, vomiting, and constipation
4. One can combine it with Da Chai Hu Tang for chronic constipation.
VI: Treats
A. Clears heat, transforms phlegm, unblocks stool
1. Commonly used for respiratory infections
2. Chest oppression and pain with sticky yellow phlegm
3. Constipation,
4. After taking this formula, stool should move, phlegm reduce, and chest discomfort alleviate
5. So for respiratory infections. Main thing, chest pain, productive cough, constipation.
Should decrease intake of meat and alcohol, eat turnips, clear and unblock bowels.
B. Purges Mucous
1. After taking formula, some patients discharge mucous, thought to be phlegm and not a problem
2. For example, there was a middle-aged guy with asthma, with Da Chai Hu Tang, after diarrhea with mucus, felt much better. He felt good after taking it.
3. What’s connection of mucus in stool from lung? May be Lung/Large Intestine connection. One should ask patients about this. Note that sometimes blood stasis comes out with the stool.
4. Example: Used for toxic exposure, had sticky stuff in stools, and felt much better.
Case History: Phlegm
Liu Duzhou treated Ms. Sun (58) for stomach duct pain, worse with pressure, pain site was swollen like an egg buts oft, she was afraid of cancer but imaging ruled it out. Pulse wiry, slippery, and forceful; white slippery tongue fur; appetite, bowels, urination all normal
Formula:
Huang Lian 9,
Quan Gua Lou 30,
Ban Xia 10
Took 3 packs, discharged a large amount of yellow, sticky fluid in the stool and symptoms resolved
VII. Formula Combinations
A. Severe chest and rib-side pain: combine with Si Ni San
B. Bitter taste in the mouth and alternating chills and fever, combine with Xiao Chai Hu Tang [This is called Chai Xian Tang]
C. For herpes zoster, post herpatic neuralgia, fibrocystic breast disease. Use Chai Xian Tang. These are often seen with alternating chills and fever, bronchitis, cholecystitis.
D. Fullness and pain in upper abdomen, combine with Da Chai Hu Tang. Da Chai Hu Tang treats a very tender chest, bronchitis, Gall Bladder. Why use Huang Lian if there is a lot of pain in the xin? Huang Lian is not the focus, but it is not contraindicated, just not indicated.
VIII. Compared with Da Xian Xiong Tang
A. Da Xian Xiong Tang treats whole abdomen, which is hard, full, and painful so it cannot be touched, stone-like hardness
B. Xiao Xian Xiong Tang just for epigastric region that is only painful when pressed
C. Both treat pain
D. Da Xian Xiong Tang is not commonly used, Da Chai Hu Tang is used much more often.
VIII. Compared with Da Chai Hu Tang
A Da Chai Hu Tang governs digestive tract counterflow,
B. Xiao Xian Xiong Tang governs respiratory tract infections
C. Both treat epigastric pain, vomiting, and constipation
D. Da Chai Hu Tang: epigastric fullness and pain, distinct abdominal fullness,
E. Xiao Xian Xiong Tang: chest oppression and pain primary, epigastric area only painful with pressure
F. For Da Chai Hu Tang hurts, XXXT xin is only tender on palpation.

Huang Lian E Jiao Tang
I. Traditional Dosages
Huang Lian 4 liang
Huang Qin 2 liang
Shao Yao 2 liang
Ji Zi Huang 2 yolks
E Jiao 3 liang
1200ml of water with 1st 3 herbs, cook down to 400ml, remove dregs and add E Jiao. Cool, then add egg yolks. Take warm in 3 doses.
II. Classical pattern
A. “When in lesser yin disease [that has lasted] more than two or three days, [there is] vexation in the heart and inability to sleep, Huang Lian E Jiao Tang governs.” (303)
B. Patient is irritable and restless, tossing and turning
C. Insomnia, irritability trying to get to sleep that is slightly better during the day
D. Difficulty focusing attention, poor memory
E. Chest oppression and palpitations
F. Fan zao and can’t sleep, too irritable to even lie down.
G. Poor memory. Poor memory is not only a kidney problem, may use this.
N.B.: Dr. Huang believes the original lines leave out some things: there should be bleeding in stool, other places. This theory is based on ingredients, both Bai Shao and E Jiao stop bleeding. This is the type of bleeding one gets with dysentery and other infections that also have epigastric distension. Bai Shao indicates there can be severe abdominal. Huang Lian has the biggest dosage, mostly for mental irritability. People will feel hot, but won’t be hot, this is “fan” or “anxiety.”
III. Additional indications
A. Epigastric focal distention
B. Abdominal pain
C. Chronic dysentery with pus and blood
D. Blood in the stool
E. Flooding and spotting (menstrual)
F. Red crimson tongue
IV. Huang Lian and Huang Qin
A. Epigastric focal distention and abdominal pain
B. Heat in the upper abdomen, indeterminate gnawing sensation, abdominal pain, tenesmus, pus and blood in the stool or fresh blood in the stool
V. Huang Qin, Huang Lian, and E Jiao
Huang Lian and E Jiao are used together to treat xue zheng (bleeding). Note the use of E Jiao in Huang Tu Tang. Huang Lian and E Jiao are used to treat dysentery, one repeatedly sees this in the Qian Jin and Wai Tai; for example in Zhu Che Wan. Tao Hong Jing’s Fu Xing Jue Zang Fu Yong Yao Ban Fa has “Xiao Zhu Niao Tang” used for “heaven-current fever,” insufficient heart strength, fire heat arising internally, fidgetiness sitting or lying. At present it is good for pure blood as in chicken or duck liver formulas. Its formulas, dosage, boiling method, are the same as Huang Lian E Jiao Tang in the Shang Han Lun.
VI. Modern Dosage
Huang Lian 5-10g
Huang Qin 10g
Bai Shao 15-30g
E Jiao 15g
Ji Dan Huang 2
Original way is to cook twice, add one egg yolk to each.
VII. Constitution
A. Medium build, white skin, ruddy complexion, skin was moist but now coarse;
red lips, tongue, and eyes, firm flesh
B. Irritable, insomnia, copious dreams, generalized heat, palpitations, tachycardia,
epigastric focal distention
C. Easily develop purpura, nosebleed, blood in stool
D. Early menses, mid-cycle bleeding, fresh red blood, sticky blood
E. Tongue
1. Tongue body is red like a strawberry, may have erosion or ulcers or cracks
2. Surface dry and lacking fluid
3. Mirror tongue, peeled tongue
4. Tongue body hard
5. The tongue is the most important sign, very red, like strawberry. Commonly it will hurt, or ulcers, or cracks. Power point has a typical picture of the tongue, leathery maybe old, cured beef looking. The opposite type of tongue counterindicates this formula.
F. Good looking, red lips are important. Firm flesh, the opposite of the Huang Qi constitution. Often have different kinds of bleeding, thus the use of Bai Shao and E Jiao, and Huang Lian also stops bleeding. Should have profuse periods, gushing feeling, what is scanty? Asking about pads is not precise, more important is the feeling, gushing or smooth, if it is otherwise it is scanty. Some women will have scanty but very viscus and bright red.
VII. Typical Uses
A. Irritability and insomnia following a febrile disease
1. After febrile disease there is often malnourishment, maybe that is why is egg yolks are needed.
Case History: Insomnia following a febrile disease
15 male, fever of 11 days, red face, red lips, red tongue, yellow coat, insomnia, sunken thin rapid pulse. Tried lots of formulas, then just combos of herbs. Dr. Huang used Huang Lian E Jiao Tang at these dosages. After the 1st dose he was much better. Dr. Huang followed up with Sheng Mai San with additions.
B. Anxiety and depression
C. Hemafecia after bacterial dysentery or typhus
Case History: (see power point, this was not translated.)
The hemafecia was accompanied by severe insomnia and irritability.
D. Thrombocytopenic purpura
1. Usually add Sheng Di Huang. Sheng Di is a stop-bleeding herb, not a bu yin herb. Xi Jiao Di Huang Tang is meant to stop bleeding. Zhi Gan Cao Tang has a large dosage, so he thinks to stop bleeding. Therefore Sheng Di and E Jiao treats uterine bleeding, also subcutaneous bleeding.
2. If stool is dry and constipated, add Da Huang. If one adds Da Huang this forms San Huang Xie Xin Tang. In the Jin Kui Yao Lüe, if one spits blood or has nose bleeds, Xie Xin Tang masters it.
Case History: Liver Disease
This was a 58 year-old women (see power point picture) with liver disease, splenomegala, blood platelets down. Bleeding from gums, everything red including tongue, stool not soft, purple macules in lower body, sleep was OK, menses vaguely normal. Face is greasy.
Dr. Huang used this formula.
Huang Lian 6
Huang Qin 12
Zhi Da Huang 6
Sheng Di 30
E Jiao 15
Bai Shao 30
One month later, she was better, smooth stools, platelets increased, proteins better. He then upped the Bai Shao to 60
E. Uterine bleeding
1. Menorrhagia, mid-cycle bleeding, early menses, bleeding with IUD, adolescent uterine bleeding, threatened miscarriage
2. Small amount of fresh red, thick blood
3. Can add Sheng Di Huang, Chi Shao, Mu Dan Pi
Case History: Irregular bleeding
This was a 48-year-old woman with diabetes for 10 years. Bleeding irregular, doesn’t stop, M.D.s wanted her to get D&C, she didn’t want one so she came to Dr. Huang. She couldn’t sleep, had discomfort in abdomen. Dry mouth, bitter taste, pain if pressed on her focal distension. After 2 packages the bleeding stopped. She took this regularly and blood sugar returned to normal. (She never took western meds for it.) Because the Huang Lian didn’t taste bitter to her he upped the dose. She called recently with back pain and he gave her a formula by phone.
F. Recurrent mouth ulcers, oral lichen planus
Case History: Mouth sores
This is a study of Cheng Feng Shi, from the “Journal of Dental Prevention andTreatment;2001. 03” He used Huang Lian E Jiao Tang with Zhu Ling Tang very effectively. Zhu Ling Tang also has E Jiao. Cheng generally used Gan Cao Xie Xin Tang. One may combine these.
G. Loss of voice from cerebral infarction
Case History: Aphasia
(1998) Woman, 80, had aphasia after stroke. She was aware but couldn’t speak. Restless, irritable, couldn’t sleep. Also had a very red tongue without coat. Added Sheng Di, Mai Men Dong and Gan Cao. Appetite also came back. Finally speech started coming back. Maybe for Alzheimer’s, stroke, etc. Need key symptoms, irritability, thin, insomnia, red tongue. Egg yolks for brain
H. Diabetes
1. Accompanied by irritability and dry mouth
I. Dry red skin
1. Used in Japan. Skin must be dry and red, but not itchy. May have bleeding from scratching. Worse with exposure to sun. E Jiao good for women’s skin or use pig’s feet. Pork, especially pork skin, like ham hocks, is good for skin. Vegetables are also good. Chicken feet also good for skin. Might be used for rosacea.
J. Caveats
1. Formula is not for long-term use
There is a large dose of Huang Lian so decoction is very bitter, not used long-term, just until symptoms are alleviated. Huang Lian will dry up skin if used too long. It will also damage the appetite. At least cut back on dosage.
2. Don’t use herbs just from the tongue picture
Many elderly people have a mirror tongue or cracked tongue, tongue crack may be congenital, many children have a geographic tongue that may be genetic, if these people do not have any problems, no need to use the formula. One needs to see fan zao, insomnia, etc. Lots of elderly have no tongue coating.
K. Common modifications
1. Bleeding: add Sheng Di Huang
2. Abdominal pain that refuses pressure: add Zhi Da Huang
3. Lower abdominal pain: add Mu Dan Pi
L. Special method for decocting E Jiao
1. E Jiao should be melted into the formula or dissolved before adding it
2. Can be pulverized and then dissolved with small amount of water or wine
3. Place in a steamer or double-boiler until dissolved, then add small amount of sugar
4. Add dissolved solution to decoction
5. Now we have powder, one can use that it is much easier.

Huang Lian Jie Du Tang
I. Traditional Dosage
Huang Lian 3 liang
Huang Qin 2 liang
Huang Bai 2 liang
Shan Zhi Zi 14 pieces
Take these four ingredients, cut up and add to 6 sheng of water, cook until 2
sheng are left and take in divided doses.
II. Original Indications
A. Intense Great Heat (? ? huo zheng)
1. This refers to fever with a prolonged high temperature or to someone with a normal
temperature that is very averse to heat, has hot soles and palms, and a red face.
B. Irritability, vomiting, groaning, odd speech, unable to sleep
1. Should have clear psychoemotional symptoms with irritability, restlessness, emotional upset, insomnia, etc. But these might be hard to elicit from patient.
2. Mild versions have decreased memory, difficulty in focusing, lightheadedness, and headache.
C. Dry Mouth
1. Tongue and mouth dry with a yellow or burnt looking tongue coating and a tongue body that is usually red with prickles.
2. One can observe this, tongue like desert, lots of prickles.
III. Typical Dosages
Huang Lian 15g
Huang Qin 10g
Huang Bai 10g
Shan Zhi Zi 15g
As a decoction.
D. Indication #1 – Acute phase of infections diseases
1. Epidemic meningitis, type B encephalitis, leptospirosis, septicemia with fever,
irritability and restlessness, and insomnia or lethargy
2. Used by both shang han and wen bing specialists. See power point. This was used by
the Jin Yuan “Four Big Schools’” Liu Wan Su directly for fevers from wai gan. Also used in Qing Dynasty with cool blood level formulas.
3. Given to chickens for aviary typhoid. Put it on feet. For ducks with hemorrhagic septicemia. If won’t eat, they force feed it.
E. Indication #2 – Acute Infectious Diseases
1. Examples include acute hepatitis, acute gastroenteritis, bacterial dysentery, urinary
tract infections, and pustular skin diseases.
2. Besides epidemic diseases it is for any dangerous disease because of its strong antimicrobial effect.
G. Indication #3 Erythmatous skin diseases
1. Erythema nodosum
2. This is a kind of auto immune disease with big blotches that are tender on the lower legs, vaculitis.
H. Indication #4 – Red, Swollen, Painful Joints
1. Rheumatoid arthritis, septic arthritis, gout
2. Can combine with ma Huang Fu Zi Xi Xin Tang Sometimes add Xiao Chai Hu Tang.
This is common combo, anti-inflammatory
I. Indication #5 Cerebrovascular Disease
1. Hypertension, cerebral infarct, cerebral hemorrhage, Alzheimer’s disease
2. Huang Lian helps memory. A well-done study in Japan used when there was anxiety, insomnia, etc.
3. Old people get very restless, just pace back and forth, rip things up, may yell, their tongues are all red.
J. Indication #6 Disease of the Oral Mucosa
1. Lichen planis oral mucosa completely red and painful, hard to eat.
2. Will help in a couple of days. Needs large amount of Gan Cao; don’t use too long.
K. Indication # 7 Sjorens syndrome
Case History: Sjorens syndrome
Sjorens syndrome, thrombocyto purpura. Platelets were very low when she come. MDs took out spleen, but RBC kept going down, gave her transfusions of platelets. Didn’t work.
Formula
Huang Lian 6
Huang Qin 6
E Jiao 20
Bai Shao 30
Sheng Di 40
Zhi Da Huang 30
Things rose very quickly. Huang Qin was used to stop bleeding, Dr. Huang increased the dosage
I. Indication # 8 Steroid therapy sequelae
1. Swollen, red, increased appetite, irritable.
J. Indication # 9. GYN pelvic inflammatory disease
1. dysmenorrhea, leucorrhoea, lots of clots
2. These women are usually buff, in their 30s
K. Indication #10. cervical erosion
1. As an external application
L. Constitution
1. This formula is very bitter, but the right constitution won’t mind.
2. Robust, pretty red in face.
3. Huang Lian E Jiao Tang types have fair skin, but Huang Lian Jie Du Tang types like drink too much, they have a greasy face, congestion of eyes, excretions from eyes, and a Huang Lian pulse.
4. Abdomen tone is OK, but uncomfortable upon palpation.
5. Emotional labile
6. Easily infected.
7. Women have leucorrhoea: profuse, yellowish-red
8. Can have athlete’s foot, pustular foot problems
9. Lab findings: HBP, increased ht rate, higher than normal hemoglobin and RBC.
M. Caveats
1. Because main herbs lower BP lower RBC etc. don’t give to anemic people
2. The person must be appropriate. Must have good appetite, if they already have bad appetitive, one must lower dosage. If they are strong, buff, don’t worry.
3. Huang Lian Jie Du Tang can affect liver function. After a couple months one must check the liver. Huang Qin is the cause. If there is bleeding, use high dosages of Huang Qin, if they don’t, lower the dose.
N. How to Take
1. Even granules can be difficult to take, in Japan they put it in apple or pear juice.
2. As decoction, take some sweets. Bensky says, coat mouth with honey, then gulp it down. Patients can figure this out. Can try to first brush teeth with toothpaste.
3. Must not too warm so they can swallow it quickly.

Dose: 1.5-9g (0.5g promotes digestion and improves the appetite)

 

 

SD on Berberine:
BACKGROUND
Berberine is an isoquinoline alkaloid with a bright yellow color that is easily seen in most of the herb materials that contain any significant amount of this compound. Among Chinese herbs, the primary sources are phellodendron and coptis (similar isoquinoline alkaloids, in these herbs, such as jateorrhizine, coptisine, palmatine, and columbamine, also have a yellowish color). Berberine has long been used as a dye; it is currently known as “natural yellow 18,” being one of about 35 yellow dyes from natural sources.
Coptis chinensis rhizomes (huanglian; literally “yellow thread”) and related species used as its substitutes have about 4-8% berberine, while Phellodendron amurense bark (huangbo, literally “yellow bo,” where bo is this particular type of tree) has about half as much, at 2-4% berberine. This compound is also found in the less commonly used Chinese herb sankezhen (B. sargentiana) and in the Japanese barberry (woody portion of Berberis thunbergii). All of these herbs are known as therapies for damp-heat syndromes, particularly for intestinal and lung infections, and they are used topically for various skin diseases. Several Western herbs also contain berberine, such as barberry root bark (Berberis vulgaris), Oregon grape root (Berberis aquifolium), and goldenseal root (Hydrastis canadensis). Berberine was isolated and used as an herbal drug in China 50 years ago (the drug forms are usually the hydrochloride or sulfate; the chloride, as used in the dye, may have the strongest antiseptic action). It has since become an ingredient in several Western herbal products, particularly for treatment of intestinal infections.
Coptis and phellodendron have been used in China for treating gastrointestinal diseases with reported success; applications have included acute gastroenteritis, cholera, and bacillary dysentery. So, the first applications of isolated berberine were for treatment of these conditions. Recent clinical trials have yielded conflicting results as to which of the disease organisms causing intestinal symptoms are responsive to berberine (1, 2). Tests of the antiseptic action of berberine against bacteria, yeasts, viruses, and amoebas have shown a range of activity levels from apparent potent action to mild suppression. Inhibition of giardia and of candida have been areas of considerable interest and initial positive research results have led to development of several herb products for those applications.
Soon after berberine was prepared as an isolated agent for clinical use, it was noted that berberine had other potential benefits; for example, it appeared to reduce high blood pressure at doses of about 1 gram per day (3). The hypotensive action of berberine has been confirmed in several pharmacology experiments, but follow-up clinical trials have been lacking. Still, this effect of berberine fortunately led to further testing of the compound for patients with cardiovascular disease risk factors, and evidence developed to demonstrate a lowering of cholesterol (and triglycerides) and of blood sugar. These new findings are the main focus of this brief report.
CHOLESTEROL
There has been increased interest in lowering blood cholesterol, and especially LDL-cholesterol, as a means of curtailing the high rates of heart attack and stroke. In addition to recommended dietary changes, many people are prescribed statin drugs for this goal. The statin drugs are powerful, frequently effective, and may have other benefits, though they also pose certain risks. During the 1990s, the Chinese herb material “red rice yeast” (Monascus purpureus) was sold in the U.S. as a natural supplement that contains, as one of its active ingredients, small amounts of lovastatin, one of the widely used statin drugs (it also contains several related compounds that contributed to the cholesterol lowering action). After prolonged legal disputes between the supplement providers, the drug companies, and the FDA about its content of the drug substance, the sale of red rice yeast and its extracts as natural cholesterol lowering agents was banned.
It was reported recently that berberine lowers cholesterol through a mechanism different than that of the statin drugs, suggesting potential use both as an alternative to the statins and as a complementary therapy that might be used with statins in an attempt to gain better control over cholesterol. In a controlled Chinese study (4), it was shown that berberine, administered 500 mg twice per day for 3 months, reduced serum cholesterol by 29%, triglycerides by 35% and LDL-cholesterol by 25%. The apparent mechanism is increasing the production of a receptor protein in the liver that binds the LDL-cholesterol, preparing it for elimination.
BLOOD SUGAR
Research on use of berberine for diabetes began with Ni Yanxi and his colleagues in Changchun (a large city in Jilin Province) with diabetes treatments. As an introduction to a 1995 English language publication on this subject (presenting their earlier clinical data from 1983-1987), they wrote (5): “It was found by accident that berberine had the therapeutic effect on the decrease of blood glucose when the authors used berberine to treat diarrhea in patients who suffered from diabetes.”
Dietary therapy was first introduced to the patients for one month. For those who still had high fasting blood sugar, berberine was administered orally at a dose of 300, 400, or 500 mg each time, three times daily, adjusting the dosage according to the blood glucose levels; this treatment was followed for 1-3 months. A control group without diabetes was similarly treated, with no effect on blood sugar. For the diabetic patients, it was reported that patients had less thirst, consumed less water and urinated less, had improved strength, and had lower blood pressure; the symptoms declined in correspondence with declining blood glucose levels. Laboratory studies suggest that berberine may have at least two functions in relation to reducing blood sugar: inhibiting absorption of sugars from the intestine and enhancing production of insulin. As relayed by Ni in his review of the literature, clinical experience with berberine has shown that doses of 2 grams per day produced no side effects.

Huang Qin – Scutellaria baicalensis root – Baical Skullcap root – Scute – (S. amoena or S. viscidula also used)

Nature: bitter, cold

Enters: Lung, Large Intestine, Liver, Gallbladder, Stomach

Actions: Clears heat; dries dampness; reduces fire; eliminates toxicity; stops bleeding; calms the fetus; sedates liver Yang rising.

Indications:
• Heat patterns (especially of the upper Jiao, but also of the middle and lower): high fever, irritability, thirst, cough, expectoration of thick, yellow sputum, hot sores and swellings (internal or topical). This herb is particularly useful for clearing Lung (and liver) heat. Also (as with Chai hu) can be used for Shaoyang syndrome.
• Damp-heat: jaundice, diarrhea, dysentery, carbuncles, boils, high fever, restlessness, thirst, rapid pulse.
• Damp warm-febrile disease: fever, stifling sensation in the chest, thirst but inability to drink. Also for Qi level heat.
• Damp heat in the lower Jiao: painful urinary dysfunction.
• Disturbance of fetus by heat (especially excess liver heat): restlessness or excessive kicking of the fetus, threat of miscarriage.
• Heat in the blood: bleeding problems such as hemoptysis, hemafecia, epistaxis, hematemesis, uterine bleeding.
• Liver Yang rising: headache, irritability, red eyes, flushed face, bitter taste in the mouth.
• Among the three “huang” herbs in this category, Huang qin is often thought of as being generally useful for upper Jiao (damp-) heat.
• This is a major herb for damp-heat in the stomach and intestines.
• Doctrine of signatures: the herb’s resemblance to lung tissue conveys its affinity for the Lungs.
• Dry-fry it to make it less cool and to help it enter the blood. This form is used for heat in the lower Jiao and restlessness of the fetus.
• Wine-fry it (Jiu huang qin) to enhance its ascending properties. This form is more effective for treating damp-heat in the upper Jiao, including lung heat, makes it easier on the spleen, and also conducts it to the blood.
• Char it to enhance its hemostatic properties.
• Beneficial in bacillary dysentery; inhibits intestinal movement.
• Broad spectrum antibiotic, antifungal.
• Antihypertensive, probably due to vasodilation; diuretic; cholagogue.
• Anti-allergic action: the component baicalein inhibits the release of enzymes from mast cells, probably by inhibiting receptors. Baicalein and baicalin have been shown to have a bronchodilatory effect in animal studies.
• The constituent baicalin is anti-inflammatory and analgesic. It is a COX-2 inhibitor, it inhibits TNF-α, and reduces PGE2. Baicalin, baicalein, and wogonin act synergistically as anti-inflammatories and are strong antioxidants.
• The constituent wogonin has been shown in one study to have anti-anxiety (though non-sedating) effects on mice.
MLT: Also has antiviral properties.
Hsu: Prevents (antigen/antibody) allergic response – for dermatitis, asthma, tracheal constriction.
DY: During pregnancy, Yang becomes stronger and easily produces heat because the creation of the fetus is a warm transformation and because the child’s Qi is added to the mother’s. As a result, it is frequent to see a restlessly stirring fetus due to Qi stagnation, Qi and/or blood deficiency, or kidney deficiency associated with heat – Huang qin can almost always be prescribed for this type of problem.
• Downbears turbid Yin.
• With Bai zhu to clear heat stirring the fetus, dry dampness, and fortify the spleen to contain the blood and the fetus. For uterine bleeding during pregnancy, threatened miscarriage, nausea and vomiting during pregnancy caused by heat or damp-heat associated with spleen deficiency which is incapable of containing the blood within the vessels. For these indications, the Bai zhu should be bran stir-fried, and the Huang qin should be stir-fried until scorched.
• With Ban xia to harmonize and re-establish the interaction between Yin and Yang, to effectively clear heat, drain fire, harmonize the stomach, stop vomiting, and scatter nodulation. For such indications as:
– 1. Vomiting and nausea due to a Shaoyang pattern. (Xiao Chai Hu Tang) Use ginger-processed Ban xia. When Huang qin is removed from Xiao Chai Hu Tang, the pain and distention of the chest and lateral costal regions disappear, but the alternating fever and chills persist. When Chai hu is used alone, the fever does not abate, but if Huang qin is added, the fever recedes efficiently.
– 2. Phlegm-heat. (Qing Qi Hua Tan Wan) Use lime-processed Ban xia and wine mix-fried Huang qin.
– 3. Lack of appetite, nausea, vomiting, and distention and sensation of fullness in the stomach, diaphragm, and chest caused by a pattern of mixed cold and heat. (Ban Xia Xie Xin Tang) Use ginger-processed Ban xia and bran stir-fried, ginger mix-fried or stir-fried-until-scorched Huang qin.• With Chai hu to harmonize the interior with the exterior, the Shaoyang, and liver and gallbladder. Together, they also clear the liver and resolve depression as well as clear and eliminate dampness and heat, particularly in the liver and gallbladder. Chai hu dispels evils (heat) limited to the superficial part of the Shaoyang. Huang qin drains evil heat limited to the internal part of the Shaoyang. For indications such as:
– 1. Alternating fever and chills, a bitter taste in the mouth, dry throat, pain and fullness in the chest and lateral costal regions, nausea, and lack of appetite due to a Shaoyang pattern. (Xiao Chai Hu Tang)
– 2. Malaria due to a Shaoyang pattern.
– 3. Liver depression transforming into fire.
– This combination is remarkably effective for hepato-biliary disorders, such as acute or chronic hepatitis, biliary lithiasis, cholecystitis, and hepatomegaly due to liver-gallbladder heat.
• With Huang lian to effectively clear heat and dry dampness, drain fire, and resolve toxins from the upper, middle, and lower burners. For specific indications of this combination, see Huang lian in this category.
• There are two kinds of Huang qin:
– Ku Qin (“Withered Scutellaria”): light weight, hollow body, dark color, floating, tropism to the Lung channel, drains Lung fire, clears the upper Jiao, drains heat from the muscles and the exterior.
Zi Qin (“Young Scutellaria”) / Tiao Qin (“Scutellaria Sticks”): dense, full, hard body, yellow and slightly green, sinking, tropism to the large intestine channel, drains large intestine fire, clears the lower Jiao, treats hot dysentery.

Dose: 3-15g

Ku Shen – Sophora flavescens root – “Bitter Root”

Nature: bitter, cold

Enters: Heart, Liver, Small Intestine, Large Intestine, Bladder

Actions: Clears heat; dries dampness; eliminates wind, stops itching; kills parasites; mildly promotes urination.

Indications:
• Damp-heat: jaundice, itchiness of the genitalia, leukorrhea, dysentery, sores.
• Wind, fungus, worms or other parasites, damp-heat-toxicity: skin problems, especially itchiness, and also seepage, bleeding. Used both internally and topically. A key herb for skin problems.
• Damp-heat in the lower Jiao (including small intestine damp-heat): painful urinary dysfunction, hot edema.
• Palpitations, arrhythmia: combine appropriately based on the diagnosis (e.g. when due to heart blood and Qi deficiency, add tonics).
• Often used in pills, powders, tinctures, ointments, and washes.
• Contraindicated in combination with Li lu
• Asthma: with Gan cao and Ling zhi in the simplified ASHMI formula.
HF: A Sha Chong (kill worms or parasites) herb, important in Gu Zheng (Gu parasites) formulas
Li: For chronic sinusitis: kills persistent microorganisms in the sinuses which promote an ongoing inflammatory process (if no results within a month, discontinue).

Dose: 3-15g (Or more for a strong topical wash)

Notes on This Category

• This category consists of two moistening herbs – Sheng di and Xuan shen – and three moving herbs – Chi shao, Mu dan pi, and Zi cao. Xi jiao should no longer be used.

• Herbs in this category are commonly combined with:
A. Herbs that strengthen the spleen and stomach, when there is deficiency of these organs.
B. Herbs that nourish Yin, when there is injury of body fluids by heat or the patient has pre-existing Yin deficiency.
C. Herbs that clear heat and reduce fire, when there is a combination of Qi and Xue level invasion.

• Herbs in other categories also cool the blood. Consider as appropriate: Bai Mao Gen [Stop Bleeding], Bai Tou Weng [Clear Heat & Toxins], Bai Wei [Clear Deficiency Heat], Ban Lan Gen [Clear Heat & Toxins], Ce Bai Ye [Stop Bleeding], Da Qing Ye [Clear Heat & Toxins], Dai Zhe Shi [Subdue Liver], Dan Shen [Move Blood], Di Yu [Stop Bleeding], Di Gu Pi [Clear Deficiency Heat], Gui Ban [Nourish Yin], Mo Han Lian (Han Lian Cao) [Nourish Yin], Huai Hua [Stop Bleeding], Luo Shi Teng [Expel Wind-Damp], Qian Cao Gen [Stop Bleeding], Qing Dai [Clear Heat & Toxins], Qing Hao [Clear Deficiency Heat], Sang Ye (charred) [Acrid, Cool], Xiao Ji [Stop Bleeding], Yin Chai Hu [Clear Deficiency Heat], Yu Jin [Move Blood], Zhi Zi [Clear Heat Reduce Fire], Zhu Ru [Resolve Phlegm].

Chi Shao Yao – Red Peony root – Paeonia veitchii (or Paeonia lactiflora)

Nature: bitter, slightly cold

Enters: Heart, Liver, Spleen

Actions: Promotes blood circulation, dispels blood stasis, relieves pain; clears heat; cools the blood; clears liver fire.

Indications:
• Blood stasis: pain and swelling (including after trauma), dysmenorrhea, amenorrhea, immobile abdominal masses. Not for amenorrhea due to cold/Yang deficiency.
• Xue level heat or heat in blood: skin eruptions, fever, purple tongue, bleeding including hematemesis, epistaxis.
• Liver fire: red, swollen, painful eyes.
• Heat-toxicity in the blood: carbuncles, boils, red, swollen eyes.
• Many sources classify this herb as a blood mover.
• Compared to Mu dan pi, Chi shao is only to be used for excess heat, while Mu dan pi can be used either for excess or deficiency. Chi shao is stronger than Mu dan pi at relieving pain.
Chi shao and Bai shao may be derived from the same plant (Paeonia lactiflora), though only Chi Shao can come from the species Paeonia veitchii. Usually, but not always, Chi shao is gathered in the wild, while Bai shao is cultivated. The two are used together for pain and irritability associated with constrained liver Qi stagnation or pain and swelling due to trauma. (See below)
• For hepatitis, Chi shao is often used in very high doses (to 60g).

• In many older sources, the name “Shao Yao” is used without differentiating between Chi Shao Yao (red peony root) and Bai Shao Yao (white peony root). Some sources say the difference is the flower color (red versus white) and others say that the medical product Chi Shao is reddish in color while the product Bai Shao is white (this may be actually due entirely to processing methods). According to the folks at NuHerbs, Bai Shao is Paeonia lactiflora with or without the “skin” on it. Their Japanese customers always requested it with the skin (making it look like what many of us believe to be Chi Shao) because they insisted that the skin is the most medicinal part. Upon lab testing it, NuHerbs found that their samples of Bai Shao with the skin removed (what most companies sell) failed quality standards, and they moved to always source the herb with the skin. Chi Shao is usually a different species – Paeonia veitchii. It lacks Bai Shao’s blood nourishing effect (some sources say it does have a weak blood nourishing effect), but is much more cooling (clears heat and cold the blood) and has the additional quality of being able to move blood (it is classified either as a blood mover or a heat-cearing & blood-cooling herb). Some sources also say that Bai Shao has some (mild) ability to move the blood. See Eric Brand’s article below for more information and a different viewpoint.
Hsu: Tranquilizes the CNS; suppresses abdominal pain caused by spasm of the smooth muscle of the small intestine; inhibits common cold viruses; dilates coronary arteries.
DY: When using many cold herbs, add Chi shao to prevent the cold from causing blood stagnation.
• For Hepatitis A and B (Chi shao regulates gamma GT and transaminases) due to liver fire or liver blood stasis. Most hepatitis (especially enduring cases) presents with blood stasis. Give 10-30g/day (depending on the severity of stasis) on a routine basis in this disease.
• With Bai shao to nourish the blood, constrain Yin, stop pain, cool the blood without causing blood stasis, and drain and nourish the liver. For such indications as:
– 1. Persistent low-grade fever due to heat in the blood. (Add Sheng di, Di gu pi, and Mu dan pi.)
– 2. Dry mouth and tongue, red and painful eyes due to insufficiency of fluids or Yin caused by residual heat. (Wine mix-fry both herbs and add Xiang fu and Dang gui.)
– 3. Lateral costal and chest pain, abdominal pain and conglomerations due to blood stasis or liver depression Qi stagnation.
– 4. Menstrual irregularities or amenorrhea caused by blood stasis, blood deficiency, and/or liver depression Qi stagnation.
Eric Brand: Bai Shao comes from one plant, Paeonia lactiflora, whereas official Chi Shao can come from two plants, P. lactiflora and P. veitchii.  The later only produces Chi Shao and is only found in the wild.  The former can produce either bai shao or chi shao and can be either cultivated or wild-crafted.  If it is cultivated and subjected to pao zhi (boiling and scraping off the root bark), it is bai shao.  If it is wild-crafted and used crude, it is chi shao.
Here’s the rub:  In ancient texts, bai shao and chi shao weren’t differentiated.  Their distinct clinical actions were only elaborated about a thousand years ago, during the Song dynasty.  Early texts, such as the Shang Han Lun, didn’t differentiate the two medicinals.  Fast forward to modern day.  The Japanese Pharmacopoeia uses only the Latin binomial Paeonia lactiflora for Shao Yao (there is no official bai shao vs. chi shao differentiation in the J.P.), and its specification for quality is based on paeoniflorin content.  Paeoniflorin is more concentrated in the root bark, so the Japanese market often imports product that hasn’t been processed (no boiling and removal of the root bark).
In China, Bai Shao and Chi Shao are regarded as two separate medicinals.  Both use paeoniflorin content for quality control testing, but the standard minimum content of chi shao is higher than that of bai shao, because bai shao naturally has less paeoniflorin due to its traditional pao zhi.  In many ways, the different spectrum of active ingredients is thought to be reflect their traditional differentiation in terms of clinical use- the higher relative paeoniflorin content found in chi shao may be related to its different clinical applications when compared to bai shao.  Personally, I would prefer to use the traditional Bai Shao product, complete with the requirements of 1) cultivated rather than wild-crafted, and 2) subjected to traditional pao zhi- boiling and removal of the root bark.  In my mind, a cultivated product with the root bark intact is almost halfway between Chi Shao and Bai Shao, not quite traditional Bai Shao and not quite traditional Chi Shao.  However, such a product is exactly what is used as Shao Yao in Japan.

Dose: 4.5-15g

Mu Dan Pi – Cortex of Tree Peony root – Moutan – Paeonia suffruticosa

Nature: bitter, acrid, slightly cold

Enters: Heart, Liver, Kidney

Actions: Promotes blood circulation; dispels blood stasis; clears heat, including deficiency heat; cools the blood; drains pus, reduces swelling; clears liver fire.

Indications:
• Heat in the blood or Xue level heat: skin eruptions, hematemesis, epistaxis, hemoptysis, subcutaneous bleeding, frequent and profuse menstruation.
• Blood stasis: dysmenorrhea, amenorrhea, uterine masses, lumps, bruises, swelling, pain due to traumatic injury. Often combined with Gui zhi.
• Yin deficiency heat: fever (especially low grade, evening), steaming bone disorder. Particularly used in the aftermath of febrile disease. Most suitable in the absence of sweating.
• Heat-toxicity in the blood: yang-type carbuncles, boils, abscesses – including intestinal abscess. Also used topically for firm, non-draining sores.
• Liver fire: headache, eye pain, flank pain, flushing, dysmenorrhea.
• Appendicitis: with Yi yi ren, Da huang.
• Lowers blood pressure. In one study using Mu dan pi to treat 20 cases of hypertension, all diastolic readings dropped 10-20 mm Hg within 33 days, and symptoms improved.
• Use it in its raw form to cool the blood.
• Dry-fry it to promote blood circulation.
• Char it to stop bleeding.
MLT: Mu dan pi’s blood circulating properties are similar to Gui zhi.
• For trauma, bruises with ecchymotic blood
• Strong downward action: not for wind-heat or Qi level heat – can drive exterior pathogens deeper into the body.
DY: Stops bleeding.
With Dan shen to quicken the blood and dispel stasis, cool the blood, and eliminate deficiency heat. For indications such as:
– 1. Hematemesis, epistaxis, metrorrhagia, purpura, and also rubella and pruritis due to heat in the blood division.
– 2. Menstrual irregularities, dysmenorrhea, amenorrhea, dark purple menstrual blood with clots, and postpartum abdominal pain due to heat in the blood which causes blood stasis.
– 3. Continuous, low-grade fever due to Yin deficiency heat. In this case, if there are night sweats, use Di gu pi instead of Mu dan pi.
– 4. Hot, red, swollen, painful joints due to hot Bi or impediment.
Mu dan pi is incompatible with garlic and coriander.
Hsu: Hypotensive, antibacterial, tranquilizing effects.

Dose: 6-12g

Sheng Di Huang – Rehmannia root (unprepared) – “Fresh Earth Yellow”

Nature: sweet, bitter, cold

Enters: Heart, Liver, Kidney, Spleen

Actions: Nourishes Yin, generates body fluids; clears heat; cools the blood; cools upward-blazing heart fire; slightly promotes bowel movement (by generating fluids).

Indications:
Ying or Xue level heat: feverish body, dry mouth, deep red tongue, hemorrhage.
• Heat in the blood: epistaxis, hematemesis, hematuria, uterine bleeding.
• Heart fire blazing upward: mouth and tongue sores, irritability, insomnia, afternoon or low grade fever, malar flush.
• Injury of Yin or body fluids by heat: constipation, dry mouth, red tongue, thirst, continuous low-grade fever.
• Yin deficiency: wasting and thirsting disorder, throat pain.
• Sheng di huang’s ability to nourish Yin is relatively weak compared to most herbs classified as Yin tonics.
• Hepatitis: Sheng di is a liver protectant.
• Rheumatoid arthritis: May reduce joint pain and swelling, improve function, nodules, and rash, and decrease temperature. May reduce ESR to normal.
• Eczema.
• Ulcerative colitis.
MLT: Antifungal, antibacterial.
• Normalizes blood sugar for diabetes mellitus.
• Stimulates new growth of flesh and bone for injuries.
PFGC: Moistens the skin, promotes a glossy appearance.
• In patients with weak stomach Qi, it may cause poor appetite.
• Can be used to gently clear away exuberant Qi – after taking it, it will bring about temporary peace.
• Contains iron – partly responsible for its ability to generate and cool the blood.
• Boosts the vessels, generates jing and marrow, brightens the eyes, clears the ears, treats taxation heat.
Hsu: Hemostatic, diuretic, lowers blood sugar.
DY: In the beginning of treatment, it can cause loose stools for 1-3 days. This side effect usually goes away on its own.
HF: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).

Dose: 9-30g

Shui Niu Jiao – Water Buffalo Horn – Bubalus bubalis

This herb is used as a substitute for Xi Jiao – Rhinoceros Horn

Nature: salty, cold

Enters: Heart, Liver, Stomach

Actions: Clears heat; cools the blood; relieves toxicity.

Indications:
Shui niu jiao and Xi jiao have basically the same functions and composition, but Shui niu jiao is significantly weaker than Xi jiao. See Xi jiao below.
• Ox horn is also used.

Dose: 30-120g in decoction, 6-15g as a powder

Xi Jiao – Rhinoceros Horn

This herb has been included only because of the important position it has held historically in classical Chinese herbal medicine. The market for this and other rare animal products has led to the endangerment and abuse of many wonderful creatures. It is seriously unethical to use this herb.

Nature: bitter, salty, cold

Enters: Heart, Liver, Stomach

Actions: Cools the blood; stops bleeding; reduces fire; eliminates toxicity; calms the Shen; relieves convulsions and tremors.

Indications:
• Heat in the blood or Ying or Xue level invasion of heat: epistaxis, hematemesis, erythema, purpura, convulsions, delirium, very high fever.
• Blockage of the heart by fire (in disease caused by damp-heat): delirium, high fever, coma.
Ying or Xue level heat: unremitting high fever, loss of consciousness, delirium, convulsions, manic behavior.
• Heat and toxicity: skin eruptions
• Used mainly for cases of extreme heat.
• Never cooked. Powdered and taken directly.
• Do not combine with aconite.

Dose: 1-2g taken directly

Xuan Shen – Scrophularia root – Ningpo Figwort – “Dark Root”

Nature: bitter, sweet, salty, cold

Enters: Kidney, Lung, Stomach

Actions: Nourishes Yin; strongly clears heat and eliminates toxicity; cools the blood; softens hardness, dissipates nodules and swellings; drains fire.

Indications:
• Stagnation of heat/fire and toxicity in the blood: swollen, severely painful throat, swollen or red eyes, carbuncles, boils, nodes in the skin. For throat problems, Xuan shen can be used for wind-heat, Lung heat, and kidney Yin deficiency patterns when combined appropriately.
Ying level heat with injury of the Yin: feverish body, dry mouth, deep red tongue.
• Heat in the blood or Xue level heat: skin eruption, restlessness, delirium, bleeding, dry mouth, purplish tongue.
• Phlegm-fire: neck lumps, enlarged lymph nodes, etc. (Often with Zhe bei mu)
• Weaker than Sheng di at nourishing Yin.
• Lowers blood pressure – especially effective for renal hypertension – probably by vasodilation.
• Dry-fry it in salt to enhance its Yin nourishing properties.
• Not to be combined with Li lu.
Li: For enlarged lymph nodes, use Xuan shen:Huang lian::1:2.
• Caution with the dosage for sore throat – its ability to generate Yin can create phlegm (2g or less per day is safe).
• Can treat hyperthyroidism
PFGC: Treats rootless kidney fire attacking the throat.
Hsu: Vasodilator; stimulates blood circulation; antiphlogistic; hypotensive; antipyretic; hypoglycemiant; antifungal.
• Use 30-90g for tuberculosis and vasculitis.
DY: Drains floating fire; disinhibits the throat.
• With Ban lan gen to clear heat, resolve toxins, cool the blood, nourish Yin, downbear fire, disinhibit the throat, disperse swelling, and stop pain. For painful, red, swollen throat with dry, red tongue, and a fine, rapid pulse due to Yin deficiency generating a deficiency fire or replete fire which damages Yin. For heat-toxins, add Shan dou gen and Gan cao. For deficiency fire, add Mai men dong and Sheng di huang.
HF: An An Shen (spirit calming) herb, important in Gu Zheng (Gu parasite) formulas (because of emotional disturbance common in patients with Gu).
NAH: (Figwort – S. nodosa) Alterative. Thought to stimulate the lymphatic system. Formerly used [in Western herbalism] to treat scrofula (tuberculosis of the cervical lymph nodes). Because of its eliminative power, it is useful for eruptive skin diseases.
PCBDP: (herb) Diuretic, depurative, anodyne.

Dose: 6-30g

Notes on This Category

• These herbs are among the coldest in the Chinese herbal pharmacopeia. Many are used for Qi level or Yangming stage full heat.

• From a Western perspective, a number of these herbs are antipyretic and some are anti-inflammatory.

• Also consider, when appropriate: Huang qin, Huang lian, Huang Bai, Da huang, Tian Men Dong, Di Yu, Jue ming zi, Han shui shi, Gu jing cao, etc.

• Herbs in this category are commonly combined with:
A. Herbs that strengthen the spleen and stomach, when there is deficiency of these organs.
B. Herbs that nourish Yin, when there is injury of body fluids by heat or the patient has pre-existing Yin deficiency.
C. Herbs that tonify Zhen Qi when used for patients with a weak constitution.

Dan Zhu Ye – Lophatherum stem and leaves – “Bland Bamboo Leaf” – (Not actually a true bamboo)

Nature: sweet, bland, cold

Enters: Heart, Stomach, Small Intestine

Actions: Promotes urination; drains Ying level heat; conducts heart heat to the small intestine (conducts Ying level heat back to the Qi level); clears damp-heat; disperses upper Jiao heat; eliminates irritability or restlessness (by clearing heat from the heart, small intestine and stomach).

Indications:
• Heat patterns with irritability, restlessness, thirst.
• Concentrated, rough, burning urination. Especially for heat in the heart/small intestine with irritability and a dark red tip of the tongue.
• Stomach or heart channel heat: canker sores or tongue sores, swollen and painful gums.
• Lingering Qi level heat.
• Some use this herb for Lung wind-heat, since it is very light and can disperse heat in the upper Jiao.
Dan zhu ye’s diuretic effect is weaker than Mu tong.
• Note: Despite the translation of its name and its similar appearance to bamboo, this herb is of the Lophatherum genus, not Bambusa (true bamboo).
Hsu: Anticarcinogenic effect; diuretic.

Dose: 6-9g

Lian Xin – Lian Zi Xin – Lotus seed heart or plumule

Nature: bitter, cold

Enters: Heart, Pericardium

Actions: Drains heart fire; stops bleeding, binds Jing

Indications:
• Warm-febrile disease: heat collapse into the pericardium channel causing mental confusion, delirium, mania.
• Heart fire: insomnia or irritability.
• Used as a powder for hematemesis, spermatorrhea.
• Lowers blood pressure, primarily by vasodilation.
Hsu: Dilates the coronary arteries; relaxes uterine smooth muscle.

Dose: 1.5-6g

Lu Gen – Reed rhizome – Phragmites

Nature: sweet, cold

Enters: Lung, Stomach

Actions: Generates body fluids; mildly promotes urination; clears heat from the Lungs and stomach; conducts Lung heat to the bladder and discharges it; promotes expression of incomplete rashes; stops vomiting; eases restlessness; eliminates phlegm.

Indications:
• Lung heat, wind-heat, or phlegm-heat: cough, dry mouth, with or without sticky yellow sputum. Especially useful in acute stage. For phlegm-heat, Lu gen dilutes the phlegm and makes it easier to expel.
• Heat in febrile disease, stomach fire: thirst, dry tongue, fever, Shen disturbance – restlessness.
• Stomach heat: vomiting, belching, nausea.
• Heat: dark scanty urine, hematuria. Especially useful when accompanied by thirst and irritability.
Lu gen can also drain pus and treat pulmonary abscesses.
• Febrile disease with rashes that are incompletely expressed.
• This herb is most potent when fresh (rather than dried).

Dose: 15-30 (up to 60g alone for incomplete expression of rashes)

Mi Meng Hua – Buddleia flower

Nature: sweet, cold

Enters: Liver

Actions: Benefits the eyes.

Indications:
• Red, swollen, painful eyes, excessively tearing, superficial visual obstruction, photosensitivity.
• Can be used in both deficiency and excess patterns.
MLT: Also for cataracts and for heat and inflammation of the face, head, throat, teeth, and gums.

Dose: 3-9g

Qing Xiang Zi – Celosia seed

Nature: bitter, slightly cold

Enters: Liver

Actions: Reduces liver fire to improve the vision and remove nebulas; clears wind-heat.

Indications:
• Liver fire or wind-heat affecting the eyes: red, swollen, painful eyes, poor vision, superficial visual obstruction, cataracts.
• Lowers blood pressure: recently used for hypertension associated with liver Yang rising. In one study with cases of 160-230 mm Hg systolic and 100-135 diastolic, blood pressure was reduced to 125-145 over 78-90 after one month of treatment with Qing xiang zi.
• Dilates the pupils.
• Not for liver and kidney Yin deficiency or glaucoma.
Hsu: Antiphlogistic; dilates the pupils.

Dose: 3-15g

Shi Gao – Gypsum – “Stone Paste”

Nature: acrid, sweet, very cold

Enters: Lung, Stomach

Actions: Clears heat and reduces fire from the Lungs and stomach; eases restlessness and thirst; the calcined form promotes tissue regeneration.

Indications:
• Lung/stomach, Yangming stage, or Qi level heat: big, forceful pulse, high fever, restlessness, thirst, profuse sweats, red tongue, yellow coat.
• Stomach channel fire: headache, swollen and painful gums, toothache.
• Lung heat: cough, wheezing, fever, thick, viscous sputum.
• Topical: use the calcined form for eczema, burns, ulcerated sores, non-healing carbuncles. This herb may also be taken internally for these conditions.
• This herb should be crushed and cooked 20-30 minutes longer than other herbs.
Shi gao is stronger at clearing Lung and stomach heat than Zhi mu or Lu gen.
Shi gao is commonly combined with Ma huang. Ma huang’s acrid quality helps to disperse Lung Qi, and its warm nature mitigates Shi gao’s coldness. Shi gao lessens Ma huang’s diaphoretic action, and its heavy quality helps Ma huang more effectively descend Lung Qi. Together, they effectively diffuse the Lungs and calm asthma, disinhibit urination and disperse swelling, clear heat and drain fire.
Li– “Shi gao is like Tylenol.” Can relieve pain and lower the body temperature.
MLT: Potent for lowering fever: high fever, including that associated with meningitis, encephalitis.
Shi gao has little or no antibiotic properties.
• If necessary for long term, repeated use (e.g. reddening of the face from food allergies), Shi hu may be a better choice.
Hsu: Reduces thirst; hypotensive; antiphlogistic; tranquilizing effect.
DY: Heavy, downbearing, draining; engenders fluids, alleviates thirst; resolves heat from the muscles and from the exterior.
• For inflammatory rheumatism or hot Bi, use 150g per day, and in severe cases, up to 250g/day.
• With Zhi mu to strongly clear and drain replete heat (from the Lungs and stomach) while protecting fluids and Yin. For such indications as:
– 1. Persistent high fever, great thirst and desire for cold drinks, dry tongue, vexation, profuse perspiration, and a surging, big pulse due to heat in the Qi division. (Use Bai Hu Tang.)
– 2. Upper thirsting and wasting with polydipsia, a dry mouth and tongue, and great thirst due to replete Lung heat damaging fluids. (Use stir-fried Zhi mu.)
• With Chuan xiong to dispel wind, clear and drain heat, quicken the blood and move the Qi, and stop pain. For headaches due to wind-heat or full heat (particularly that which is located in the Shaoyang or Jueyin channels). Use unprepared Chuan xiong. For wind-heat headaches, add herbs that dispel wind. Usual dosage of Shi gao for these indications is 30-60g.
• With Gui zhi to clear heat, free the flow of the network vessels, stop pain, and treat heat Bi or impediment. For such indications as rheumatic pain of the heat type with redness, heat, swelling, and severe pain in the joints. (Bai Hu Gui Zhi Tang)

Dose: 9-30g (to 90g for very high fevers)

Tian Hua Fen – Trichosanthes root – “Heavenly Flower Powder”

Nature: bitter, slightly sweet, cold

Enters: Lung, Stomach

Actions: Strongly clears heat from the Lungs and stomach; strongly drains pus and relieves swelling; transforms phlegm; generates body fluids, moistens Lung dryness; relieves toxicity.

Indications:
• Heat injures the body fluids: restlessness, irritability, thirst, cough, dry tongue coat, wasting and thirsting disorder.
• Heat in the Lungs: cough, including dry cough, or coughing blood-streaked sputum
• Heat and toxicity: red, swollen, painful carbuncles, boils, other swellings, sores. Especially useful for breast abscess (both internally and topically).
• Diabetes: heat in the Lungs and stomach with strong hunger and extreme thirst. Use 60-90g or more.
• Abortifacient (used 2nd trimester) – applied via a tea-soaked tampon or IM injection (also with She xiang) – takes 3-6 days to have an effect.
• compared to Mai men dong and Tian men dong, Tian hua fen is best for Lung For heat and dryness, Tian hua fen is most useful for when the origin is stomach heat. Mai men dong is superior when the origin is heart fire, and Tian men dong is superior when the origin is kidney Yin deficiency.
Tian hua fen is much stronger than Lu gen at relieving swelling and draining pus.
• Bensky/Gamble and MLT classify this with herbs that resolve phlegm-heat.
• Some people are allergic to this herb.

Dose: 9-30g
Contains Compound Q/Trichosanthin/GLQ223 – a protein which has been utilized in the treatment of various kinds of ulcers, as an abortifacient, and to treat diseases of trophoblastic origin, such as hydatiform mole, invasive mole, choriocarcinoma. It appears to inhibit HIV-1 replication in acutely infected T-lymphoblastoid cells and chronically infected macrophages, and appears to selectively kill HIV-infected cells.
It produces an anaphylactic reaction in 10-20% of users. Pharmaceutical companies have produced chemically modified variations for greatly reduced allergenicity.
CHA: (Harriet Beinfield, Efrem Korngold, March 7, 2001):
Weidong Lu, MD, L.Ac., Chairman of the Chinese Herbal Medicine Department at the New England School of Acupuncture, explains that trichosanthin is a type of protein that is inactivated by digestive enzymes or by decocting the herb in boiling water. Trichosanthin cannot be absorbed as an active protein by the intestine from either the crude herbal material or the water extract. He further states that trichosanthin can only exert toxicity via intravenous or intramuscular injection, and that overdoses of injected Trichosanthes root may cause allergic reactions that include malaise, sore throat, headache, swelling, itching, and rashes. He maintains that Trichosanthes root is non-toxic when consumed orally in appropriate doses.

Xia Ku Cao – Prunella spike – Selfheal – “Summer Withered Herb”

Nature: bitter, acrid, cold

Enters: Liver, Gallbladder

Actions: Clears liver fire; brightens the eyes; disperses stagnant phlegm and fire, dissipates nodules.

Indications:
• Liver fire: red, swollen, painful eyes, lots of tears, dizziness, photophobia, headache.
• Liver deficiency: eye pain that increases in the evening, especially when the eyes are neither red nor swollen.
• Stagnant phlegm-fire: neck nodules, lipomas, swollen glands, scrofula, goiter. Also for similar nodules in the inguinal groove or other parts of the body.
• Mildly reduces hypertension (probably through vasodilation), especially when accompanied by liver fire or Yang rising.
• Broad antimicrobial (tuberculosis, shigella, salmonella, E. coli, pseudomonas, strep, many other fungi and bacteria).
Li: Softens hardness: thick blood, lumps (including hyperthyroidism), hardened skin in eczema.
MLT: Also for conjunctivitis; some cancers.
PCBDP: Astringent, vulnerary.

Dose: 9-15g (up to 30g taken alone)

Ye Ming Sha – Bat Feces

Nature: acrid, cold

Enters: Liver

Actions: Clears the liver and improves vision.

Indications:
Night blindness, superficial visual obstruction, cataracts.
Also used for childhood nutritional impairment.
Doctrine of signatures: bats are blind, fly at night – for vision, especially at night.

Dose: 3-9g

Zhi Mu – Anemarrhena rhizome – “Know About Mother”

Nature: bitter, sweet, cold

Enters: Lung, Stomach, Kidney

Actions: Mildly nourishes Yin, moistens dryness; clears heat and reduces fire from the Lungs, stomach, and kidneys.

Indications:
• Extreme heat in the Lungs and stomach, Yangming stage or Qi level: high fever, restlessness, irritability, thirst, big, rapid, forceful pulse.
• Lung heat (including Yin deficiency): cough, including with thick, yellow sputum.
• Kidney (and Lung) Yin deficiency: tidal fever, night sweats, restlessness, steaming bone disorder, irritability, warmth in the five centers, bleeding gums.
• Also for kidney heat signs such as spermatorrhea, nocturnal emissions, and an abnormally elevated sex drive.
• Lung, stomach, and kidney Yin deficiency: excessive thirst, hunger, and urination – diabetes (often used with Tian hua fen).
• Treats both excess and deficiency heat.
• For excess Lung heat, it is often combined with Huang qin. For Lung Yin deficiency heat, it is often uses with Mai men dong. For excess stomach heat, it is commonly combined with Shi gao. For stomach Yin deficiency heat, it is used with Tian hua fen. For kidney Yin deficiency heat, it is often used with Huang bai and Shu di.
• Fry it in salt water to strengthen its ability to nourish the kidneys and to direct the actions of a formula downward.
Li: Can lower the body temperature.
DY: Treats all three Jiaos; clears the Qi division; drains deficiency fire from the lower burner, drains [aberrant] ministerial fire.
• If thirst is predominant, bran stir-fried or honey mix-fried Zhi mu should be used.
• If dry cough is predominant, Zhi mu should be stir-fried until scorched.
• With Bai he to moisten the Lungs and clear heat, nourish the heart and quiet the spirit. For such indications as:
– 1. Vexation and agitation, insomnia, vertigo, thirst related to a warm disease which has damaged Yin or due to Yin deficiency with deficiency heat.
– 2. Dry cough, vexation and agitation after a warm disease.
– 3. Lily disease.
• With Chuan bei mu to clear and moisten the Lungs, enrich Yin, drain fire, transform phlegm, and stop cough. For such indications as:
– 1. Enduring dry cough with little phlegm and difficult expectoration, sometimes fever, dry mouth, and a dry, red tongue due to water deficiency causing rising fire or due to Lung Yin deficiency. (Use stir-fried Zhi mu)
– 2. Cough due to Lung heat which causes Lung dryness.
• With Huang bai to clear heat, enrich Yin, drain deficiency fire, resolve toxins, and eliminate dampness in the lower burner. For such indications as:
– 1. Evening fever, steaming bones, and night sweats caused by Yin deficiency. – 2. Seminal emission, premature ejaculation, easy erection, excessive thinking about sex, sexual hyperexcitability, erotic dreams, nymphomania due to deficiency fire and hyperactive ministerial fire.
– 3. Dysuria due to Yin deficiency and to Yang losing its ability to transform (at the level of the bladder). For all these indications, both herbs should be salt mix-fried to guide their action toward the lower burner and kidneys.
• With Shi gao to strongly clear and drain replete heat (from the Lungs and stomach) while protecting fluids and Yin. For such indications as:
– 1. Persistent high fever, great thirst and desire for cold drinks, dry tongue, vexation, profuse perspiration, and a surging, big pulse due to heat in the Qi division. (Use Bai Hu Tang.)
– 2. Upper thirsting and wasting with polydipsia, a dry mouth and tongue, and great thirst due to replete Lung heat damaging fluids. (Use stir-fried Zhi mu.)
MLT: Broad spectrum antibiotic; has a downward energy, helps lubricate the kidneys.
• For heat with thirst unrelieved by drinking.
Hsu: Reduces blood sugar; antibacterial.

Dose: 6-12g

Notes from Dr. Hong Jin, DAOM, at Oregon College of Oriental Medicine

Dr. Jin’s most used OBGYN formulas and the primary conditions for which they’re used. The indications given in parentheses after each formula are examples, but, of course, each formula is not limited to these indications, nor is it necessarily appropriate to treat each example indication with the unmodified formula. Make a good diagnosis!

Ai Fu Nuan Gong Wan: xiang fu, ai ye, dang gui, huang qi, wu zhu yu, chuan xiong, bai shao, shu di, rou gui, xu duan  (infertility due to K yang xu)

Ba Zhen Yi Mu Tang: Ba Zhen Tang + yi mu cao (amenorrhea due to blood xu, fibroids due to blood stasis + Qi/blood xu, infertility & habitual miscarriage due to Blood stasis)

Bao Yin Jian: “protect yin” sheng di, shu di, bai shao, shan yao, huang qin, huang bai, xu duan, gan cao: nourish yin, clear heat (threatened miscarriage due to blood-heat, habitual miscarriage due to K yin xu)

Bi Xie Shen Shi Tang: bi xie, yi yi ren, huang bai, fu ling, ze xie, mu dan pi, tong cao, hua shi: clear heat < dry damp (leukorrhea due to damp-heat, infertility due to damp-heat)

Bu Shen Gu Chong Wan: tu si zi, xu duan, ba ji tian, du zhong, lu jiao jiao, dang gui, shu di, gou qi zi, e jiao, dang shen, bai zhu, da zao, sha ren: tone/warm K yang, strengthen GV, nourish blood, tone/raise Qi, resolve damp (habitual miscarriage due to K yang xu)

Bu Zhong Yi Qi Wan: huang qi, ren shen, bai zhu, zhi gan cao, dang gui, chen pi, sheng ma, chai hu (threatened miscarriage due to Sp Qi/blood xu)

Cang Fu Dao Tan Wan: cang zhu, fu ling, ban xia, chen pi, gan cao, xiang fu, dan nan xing, zhi ke, sheng jiang, shen qu (amenorrhea & infertility due to phlegm-damp)

Da Huang Zhe Cong Wan: da huang, tu bie chong, tao ren, gan qi, qi cao, shui zhi, meng chong, huang qin, xing ren, sheng di, bai shao, gan cao: break up Blood stasis, NB (fibroids due to Blood stasis or Blood stasis + Qi/blood xu)

Er Zhi Wan: nu zhen zi, han lian cao (infertility due to K yin xu)

Fu Tu Dan: tu su zi, wu wei zi, shan yao, lian zi, fu ling: stabilize K Qi, stop leakages, strengthen Sp
(leukorrhea due to K Qi/yang xu)

Fu Zi Li Zhong Wan: fu zi, gan jiang, ren shen, bai zhu, zhi gan cao: warm yang, dispel cold, tone Sp Qi (menopause due to K yang xu)

Ge Xia Zhu Yu Tang: dang gui, chuan xiong, tao ren, mu dan pi, chi shao, wu yao, yan hu suo, gan cao,xiang fu, hong hua, zhi ke, wu ling zhi (amenorrhea due to Qi/Blood stasis)

Gu Ben Zhi Beng Tang: “stabilize the root & stop excess uterine bleeding”  shu di huang, bai zhu, ren shen, huang qi, dang gui, pao jiang: tone blood, augment Qi, stop bleeding (uterine bleeding & habitual miscarriage due to Sp Qi xu)

Gui Zhi Fu Ling Wan: gui zhi, fu ling, shan yao, mu dan pi, tao ren: invig blood, transform Blood stasis, reduce ab. masses (fibroids due to Blood stasis & Blood stasis + Q//Blood xu)

Jia Wei Shi Xiao San:  sudden smile (pu huang, wu ling zhi) + dang gui, chi shao, yi mu cao, xiang fu   (uterine bleeding due to Blood stasis)

Jia Wei Wu Yao Tang:  wu yao, sha ren, mu xiang, yan hu suo, xiang fu, gan cao, bing lang  (amenorrhea due to Qi/Blood stasis)

Jin Gui Shen Qi Wan: shu di, shan zhu yu, shan yao, ze xie, fu ling, mu dan pi, gui zhi, fu zi (menopause due to K yang xu)

Jing Qin Si Wu Tang: Si Wu + jing jie tan, huang qin: nourish Lv blood, clear heat (xu/shi), stop bleed (uterine bleeding due to blood heat)

Ju Yuan Jian: “raise yuan qi” ren shen, huang qi, bai zhu, zhi gan cao, sheng ma (threatened miscarriage due to Sp Qi/blood xu)

Liu Wei Di Huang Wan: shu di, shan zhu yu, shan yao, fu ling, ze xie, mu dan pi (amenorrhea & infertility due to Lv/K yin xu)

Long Dan Xie Gan Tang: long dan cao, huang qin, zhi zi, mu tong, che qian zi, ze xie, chai hu, sheng di, dang gui, gan cao (leukorrhea & infertility due to damp-heat + Lv fire)

Qi Gong Wan: “open uterus”  ban xia, xiang fu, cang zhu, shen qu, fu ling, chen pi, chuan xiong (fibroids due to Blood stasis + phlegm accumulation)

Qi Ju Di Huang Wan: gou qi zi, ju hua, shu di, shan zhu yu, shan yao, fu ling, ze xie, mu dan pi (fibroids due to Blood stasis + Lv/K yin xu, menopause due to K yin xu)

Qing Jing San: mu dan pi, bai shao, shu di huang, di gu pi, qing hao, fu ling, huang bai (uterine bleeding due to blood heat)

Qing Re Gu Jing Tang: ‘clear heat & stabilize menses’  huang qin, zhi zi, sheng di, di gu pi, di yu, e jiao, ou jie, zong lu zi, gui ban, mu li, gan cao (habitual miscarriage due to blood-heat)

Qing Re Zhi Beng Tang: ‘clear heat & stop excess uterine bleeding’  zhi zi, huang qin, huang bai, sheng di huang, mu dan pi, di yu, ce bai ye tan, chun gen bai pi, gui ban, bai shao: clear heat, stop bleeding (uterine bleeding due to blood-heat)

Shao Fu Zhu Yu Tang: xiao hui xiang, gan jiang, yan hu suo, dang gui, chuan xiong, mo yao, rou gui, chi shao, pu huang, wu ling zhi: invigorate blood, dispel Blood stasis, warm menses, alleviate pain (amenorrhea, fibroids, infertility & habitual miscarriage due to blood stasis)

Sheng Yu Tang: ‘sage-like healing’ ren shen, huang qi, dang gui, chuan xiong, shu di huang, bai shao (threatened miscarriage due to fall/trauma)

Shou Tai Wan: ‘fetus longevity’ tu si zi, sang ji sheng, xu duan, e jiao (+huang qi) (threatened miscarriage due to K xu)

Si Miao Wan: cang zhu, huang bai, chuan niu xi, yi yi ren: drain Damp-heat from lower jiao & genitals (leukorrhea & infertility due to damp-heat, damp greater than heat)

Si Wu Tang: shu di, dang gui, bai shao, chuan xiong (infertility due to K yin xu, + Shi xiao san for habitual miscarriage due to blood xu)

Tai Shan Dan Shi San: dang gui, huang qi, shu di, xu duan, fu ling, chuan xiong, bai shao, bai zhu, sha ren, zhi gan cao (threatened miscarriage due to K xu + Sp Qi/blood xu)

Wan Dai Tang: bai zhu, shan yao, ren shen, bai shao, che qian zi, cang zhu, chen pi, jing jie tan, chai hu, gan cao (leukorrhea due to Sp xu + turbid phlegm)

Xiao Yao San: chai hu, bai shao, dang gui, fu ling, bai zhu, zhi gan cao, bo he (amenorrhea due to Qi/blood stag, fibroids due to Blood stasis, infertility due to Lv Qi stag: + mu dan pi, xiang fu, tian hua fen)

Yi Huang Tang: “change yellow [discharge]” shan yao, qian shi, huang bai, bai guo, che qian zi (leukorrhea & infertility due to damp-heat + Sp/K xu)

You Gui Wan:  fu zi, rou gui, lu jiao jiao, shu di huang, shan zhu yu, shan yao, gou qi zi, tu si zi, du zhong, dang gui: warm & tone K yang, nourish blood & jing (amenorrhea, uterine bleeding, leukorrhea & menopause due to K Qi/yang xu)

Yu Dai Wan: shu di, bai shao, dang gui, chuan xiong, chun gen pi, huang bai, gao liang jiang: strengthen kidneys, build blood, stop bleeding and vaginal discharge, clear damp-heat (recurrent yeast infections, leukorrhea)

Zan Yu Dan: ‘special pill to aid fertility’ fu zi, rou gui, rou cong rong, ba ji tian, yin yang huo, she chuang zi, jiu zi, xian mao, shan zhu yu, du zhong, shu di, dang gui, gou qi zi, bai zhu (infertility due to K Yang xu)

Zhi Bai Di Huang Wan: huang bai, zhi mu, shu di, shan zhu yu, shan yao, fu ling, ze xie, mu dan pi (fibroids due to Blood stasis + Lv/Ki yin xu, uterine bleeding, infertility & menopause due to K yin xu)

Zhi Dai Wan: ‘stop vaginal discharge’ zhu ling, fu ling, che qian zi, ze xie, yin chen hao, chi shao, mu dan pi, huang bai, zhi zi, niu xi
(leukorrhea & infertility due to damp > -heat)

Zuo Gui Wan: shu di huang, shan yao, shan zhu yu, gou qi zi, chuan niu xi, tu si zi, lu jiao jiao, gui ban jiao: nourish K Yin and blood, strengthen Ren & Chong Mai (uterine bleeding & infertility due to K yin xu)

Notes on This Category

• Since the dispersing effect of some of the more aromatic herbs in this category depends on their volatile oils, they are often decocted only for a short time (or are infused only).
• Also consider for wind-cold patterns when appropriate: Xi xin, Du Huo, Cang Zhu, Chuan xiong, Huo xiang, Ju hong, Wu gong, Jiang huang, Bai shao, etc.

Bai Zhi – Angelica dahurica root

Nature: acrid, warm

Enters: Lung, Stomach

Actions: Eliminates wind-cold; dries dampness; relieves swelling and drains pus; alleviates pain by eliminating wind; conducts to the Yangming channels; opens the nasal passages.

Indications:
• Wind-cold: frontal headache, nasal congestion, supraorbital pain, toothache, or any other problem due to wind invading the Yangming channels in the head (can be used for heat syndromes when appropriately combined – e.g. for frontal headache due to wind-heat when combined with Shi gao).
• Headache due to sinusitis – key herb (not for headaches due to blood deficiency).
• Carbuncles and surface sores: dissipates swelling before there is pus or drains the pus after it has developed.
• Cold and damp in the lower Jiao: leukorrhea (combined appropriately, can be used for damp-heat also).
• Prevention of colds: increases IgA, IgM in the nose (by smelling it – usually hung in a container around the neck).
• Used in prevention of corneal ulcers secondary to burns.
• Used topically for freckles, maybe acne, hyperpigmentation, other blemishes.
• Liu: the ultimate herb for pus.
• A powder of Bai zhi and Bing pian, when inhaled through the nose, has been effective in treating headache, toothache, trigeminal neuralgia.
HF: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas.
Li Dong Yuan: Upbears Yang Qi.
Eric Brand: We now think of Bai Zhi as being an exterior-resolving agent that is suitable for wind-cold patterns, especially cases that are characterized by sinus congestion and headache. In truth, Bai Zhi’s actions are quite diverse, and it is an important medicinal for both internal and external applications (it relieves itching and is often featured in topical formulas for itching). Its actions of relieving headache and sinus congestion go far beyond the context of external contraction, which is often expressed by the action phrase “dispels wind and relieves pain.” It is indicated for yang ming channel headache, eyebrow bone pain, “head wind” headache, toothache, and deep-source nasal congestion.
Most practitioners remember Bai Zhi’s actions to resolve the exterior, treat headache, and open the nose. However, all too often practitioners forget that Bai Zhi disperses swelling and expels pus; here, it is used for painful swollen sores and welling-abscesses. To disperse swelling before the rupturing stage, combine it with heat-clearing toxin-resolving medicinals such as Jin Yin Hua (Lonicerae Flos) and Tian Hua Fen (Trichosanthis Radix). After pus has formed, combine it with supplementing medicinals such as Ren Shen (Ginseng Radix), Huang Qi (Astragali Radix), and Dang Gui (Angelicae Sinensis Radix) to expel pus.
Bai Zhi is aromatic and reaches upward, so it is often used to treat disorders affecting the head (headache, sinus congestion, etc). However, it is also a key medicinal that should not be overlooked for treating vaginal discharge. Bai Zhi is acrid, warm, aromatic and drying, so it is particularly appropriate for cold-damp patterns of vaginal discharge. To treat copious white vaginal discharge due to cold-damp pouring downwards, combine it with medicinals to warm yang, dry dampness, and fortify the spleen, such as Lu Jiao Shuang (Cervi Cornu Degelatinatum), Bai Zhu (Atractylodis Macrocephalae Rhizoma), and Shan Yao (Dioscoreae Rhizoma). Although it is warm in nature, it can also be used for yellow or reddish vaginal discharge due to damp-heat when combined with medicinals such as Che Qian Zi (Plantaginis Semen) and Huang Bai (Phellodendri Cortex).
If we look at the indications and historical applications of Bai Zhi, it is obvious that it is an important medicinal that transcends many normal limits of use. It is warm and acrid, so we often combine it with other warm, acrid agents to treat cold patterns. However, we also use it in conjunction with cold herbs to treat hot conditions characterized by swelling and pus, as well as hot patterns of vaginal discharge. It is famous for conditions affecting the head and upper body, but it is also an important medicinal for vaginal discharge and intestinal wind in the lower body. Such paradoxical and wide-ranging indications are very interesting and unusual. If one searches the Chinese formula literature based on Bai Zhi, one will discover that a stunning number of formulas based on Bai Zhi exist (over 30 formulas share the name Bai Zhi San alone). These formulas span a wide range of internal and external conditions and really illustrate its profound spectrum of use.
Bai Zhi is differentiated into two primary sources: Angelica dahuricae (Fisch.) Benth. Et Hook. and Angelica dahurica var. formosana (Boiss.) Yuan et Shan. The latter, called Hang Bai Zhi, is characterized by the presence of square rings that can be seen upon the transverse cross section. The product pictured above is Chuan Bai Zhi, which only has round rings. Hang Bai Zhi has some round and some square rings, whereas Chuan Bai Zhi only has round rings. Hang Bai Zhi is considered to be slightly superior but Chuan Bai Zhi is more abundant on the market (according to some sources, Chuan Bai Zhi accounts for about 70% of the market supply). Both are acceptable forms.
Weng Weiliang, et. al.:
• Anti-bacterial effect: Escherichia coli, Shigella dysenteriae, Proteus vulgaris, Salmonella typhi, Pseudomonas aeruginosa, Vibrio cholerae, and Mycobacterium tuberculosis var. hominis were found to be susceptible to the decoction of Angelica Dahurica.
• Use in ophthalmology: A burn ointment, which included ground Radix A. duhurica has been effective in promoting healing and avoiding deleterious sequelae from corneal ulcers secondary to flash burns.
• Use in otolaryngology: A powder made up of ground Radix A. dahurica and Borneol, when inhaled through the nostrils, has been effective for headache and toothache. It also proved to be of use in trigeminal neuralgia.

Dose: 3-9g

Cang Er Zi – Xanthium fruit – Cocklebur – “Deep Green Ear Seeds”

Nature: acrid, bitter, warm, slightly toxic

Enters: Lung

Actions: Opens the nose; eliminates wind-damp, alleviates pain; dispels wind.

Indications:
• Wind-damp/wind-cold-damp: Bi syndrome, sinusitis, congestion, whitish discharge, headache.
• Wind-damp: skin disorders with itching, painful obstruction.
• Eliminates wind (auxiliary herb) for exterior syndromes with splitting headache radiating to back of the neck.
• Topical: local application in sesame oil for chronic rhinitis.
• Im injection for low back pain.
• Bensky/Gamble: eliminate wind-damp category.
Hsu: Antibacterial, decoction cures chronic arthritis and syphilitic neuralgia.
DY: Diffuses the Lung Qi.
• With Xin yi hua to effectively dispel wind, diffuse the Lung Qi, and open the portals of the nose. These two herbs are probably the two most efficient Chinese medicinal substances for all types of rhinitis and sinusitis. For the following indications, use the base formula Cang Er Zi San with these amendments: for wind-cold, add Xi xin, Huo xiang, Ma huang, and subtract Bo he; for wind-heat, add Ju hua, Jin yin hua, Lian qiao; for gallbladder heat, add Yu xing cao, Long dan cao, Huang qin; for Lung-spleen Qi deficiency, add Huang qi, Bai zhu, Dang shen, and subtract Bo he.
– 1. Common cold with headache, nasal congestion, and runny nose due to wind-cold.
– 2. Deep source nasal congestion with headache, nasal congestion, loss of smell, and turbid nasal phlegm.
– 3. Chronic or acute rhinitis, allergic rhinitis, hypertrophic rhinitis, sinusitis, parasinusitis, and frontal sinusitis.
Cang er zi is incompatible with horse meat or pork.

Dose: 3-9g
Cang Er Cao: the herb (stem and leaves)
• Bitter, acrid, slightly cold, slightly toxic.
• Expels wind; clears heat; eliminates toxicity.
• For wind-damp: Bi syndrome with spasms and pain in the extremities.
• Deep-rooted skin lesions and pruritis.
• Generally used topically.
• Not for long-term internal use, particularly by those who are very weak.
6-15g

Cong Bai – Scallion – Spring Onion (white part with root)

Nature: acrid, warm

Enters: Lung, Stomach

Actions: Mildly releases the exterior by promoting sweats; disperses cold and activates Yang; eliminates toxicity, dissolves swellings; conducts Yang to the surface.

Indications:
• Mild wind-cold EPI : especially in the very early stage (often with Dan dou chi).
• Excess cold keeping the Yang on the surface of the body: diarrhea, cold extremities, feeble pulse, abdominal pain and distention, nasal congestion.
• Sores, abscesses, mastitis (often applied externally as a poultice).
• Combining with honey can upset the stomach.
• When decocting, cook only for a short time.
• When there is floating Yang due to deficiency, the use of Cong bai alone could make it collapse – this must be treated with Yang tonics or herbs which warm the interior (e.g. Fu zi, Gan jiang).
DY: Guides the action of other herbs to the Lung channel.

Dose: 2-5 pieces

Fang Feng – Siler root – Ledebouriella – Saposhnikovia divaricata – “Guard Against Wind”

Nature: acrid, sweet, warm

Enters: Bladder, Liver, Spleen

Actions: Releases the exterior by eliminating wind, cold, and dampness; relives pain; relieves convulsions and tremors; alleviates itching.

Indications:
• Wind-cold-dampness: headache, body ache, aversion to cold or joint pain, muscle spasm in the limbs.
• External wind: tetanus, trembling of the hands and feet.
• Spleen and liver disharmony: intestinal wind – recurrent, painful diarrhea with bright blood in the stool.
• Migraines.
• Deeper effect than Jing jieFang feng reaches the muscles and tendons while Jing jie is more for the skin level. Qiang huo which penetrates to the bones and tendons, reaches deeper than Fang feng.
• Analgesic, mild antipyretic.
Fang feng’s chief function is to disperse wind. Can be combined with Huang qi to prevent wind (e.g. in Jade Wind Screen).
• Not for convulsions due to blood deficiency or Yin deficiency fire.
Liu: May free stagnant liver Qi.
SD: May help antidote arsenic poisoning.
DY: With Huang qi to supplement the defensive Qi without retaining external evils in the body, to drain external evils without damaging correct Qi and without causing perspiration, to secure the exterior, prevent invasion by external evils, and stop perspiration. This combination appears in Yu Ping Feng San for indications such as:
– 1. Spontaneous perspiration due to exterior deficiency.
– 2. Tendency to contract EPIs frequently due to defensive Qi deficiency.
Yu Ping Feng San should not be used to treat wind affections that are already established. This combination is too astringent once the evil Qi and the defensive Qi are already struggling. Its use might, in this case, retain the external evil inside the body.
– The pair Fang feng and Huang qi, when combined with Zhi ke, yields good results in the treatment of prolapse of the rectum, external hemorrhoids, flatulence, and abdominal distention. For rectal prolapse, the best approach is to add 3g Fang feng and 6g Zhi ke to Bu Zong Yi Qi Tang.

Dose: 3-9g

Gao Ben – Ligusticum root – Chinese Lovage

Nature: acrid, warm

Enters: Bladder

Actions: Releases the exterior and alleviates pain by dispersing cold; eliminates wind and damp; guides to the bladder channel and organ; reaches both ends of the Du Mai.

Indications:
• Wind-cold: headache, especially severe parietal headache radiating to the cheek and teeth, occipital headache, or migraine.
• Any wind pattern that presents as pain at the vertex or pain that travels from the vertex down to the cheeks and teeth.
• Wind-cold-damp: Bi syndrome, joint pain.
• Wind-cold: acute lower back pain (the herb reaches both ends of the Du Mai).
• Warm, dry, ascending, dispersing nature.
• Not for headaches due to blood deficiency.
Hsu: Antispasmodic, emmenagogue, antiphlogistic, antifungal.
HF: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas.
Li Dong Yuan: Upbears Yang Qi.

Dose: 3-9g

Gui Zhi – Cinnamon twig

Nature: acrid, sweet, warm

Enters: Heart, Lung, Bladder, Liver

Actions: Releases the exterior by promoting sweats; warms the channels; activates Yang; disperses cold; promotes blood circulation; frees the bladder channel to promote urination; adjusts the Ying and Wei Qi; warms and facilitates the flow of Yang Qi in the chest.

Indications:
• Wind-cold: fever, aversion to cold, headache, sweating or no sweating.
• Wind-cold-damp: Bi syndrome, sore joints, back, limbs, and especially shoulders.
• Heart and spleen Yang deficiency: retention of phlegm and harmful fluid.
• Heart Yang deficiency or obstructed flow of Yang Qi in the chest (shi or deficiency): chest pain, palpitations, irregular pulse, or angina pectoris.
• Cold obstructing the channels/blood: dysmenorrhea, amenorrhea, masses in the uterus/abdomen.
• Cold-phlegm accumulation or weak movement of Yang Qi: edema.
• To promote sweating, use with Ma huang (Ma huang opens the pores, Gui zhi pushes the sweat out), especially for Yangming stage.
Wei and Ying imbalance: deficiency patterns where sweating occurs without improvement.
• Diuretic; mild antipyretic (primarily by vasodilation); some antibiotic effects.
• Compared to Ma huang in the treatment of wind-cold: while Ma huang works more directly by opening and disseminating the Lung Qi, Gui zhi works more by aiding the Yang Qi – this gives it the ability to treat either wind-cold excess or deficiency.
• For EPIs, smaller doses are usually used (3-9g) while larger doses (9-15g) are used for dispelling painful obstruction.
Li: Harmonizes the heart and kidneys; warms cold extremities; useful for palpitations.
PFGC: Enters the upper extremities; enters the muscle layer – primary herb to relieve the muscles; opens the energy pathways, raises the ancestral Qi up, descends counterflow of Qi (asthma, coughing), disperses pernicious Qi; keeps the upflaring tendency of liver wood in check; helps collapsed spleen Qi rise and rebellious stomach Qi descend.
• Its pungency disperses while its sweetness tonifies: it is therefore somewhere between dispersing and tonifying.
• By harmonizing the Ying and Wei, it can astringe sweats due to wind injuring the Wei, which in turn cannot attend to the Ying, which becomes weak and cannot secure fluids. it can induce sweating by regulating the Ying, which lets the Wei be harmonious by itself, which then forces sweat out to release the wind.
Hsu: Analgesic (raises pain threshold in brain); alleviates headache due to spasm of blood vessels in the head and relieves abdominal pain due to spasms of smooth muscle of the viscera; stimulates gastric secretions and saliva; markedly inhibits influenza virus.
DY: Promotes perspiration and resolves the exterior without damaging Yin; tropism: the blood division; quickens the network vessels; supplements spleen Yang; relieves the muscles; frees the flow of Yang and promotes urination by stimulating the function of transformation of the bladder.
• Treats edema of the damp type due to deficiency of the transformative function of the bladder.
• With Bai shao to harmonize Yin and Yang, the Qi and the blood, and the constructive and the defensive. This combination drains without damaging Yin, while constraining without retaining evils. They harmonize the vessels, relieve tension and stop pain, as well as support stomach Yin and spleen Yang, while regulating the spleen and stomach. For indications such as:
– 1. Common cold with fever, shivers, slight perspiration, no thirst, headache, thin white tongue fur, and a floating, moderate pulse or, in other words, a wind-cold exterior pattern with disharmony between the constructive and the defensive. (Take Gui Zhi Tang. 10 minutes later, eat very hot rice porridge, and stay well covered in bed to promote perspiration.)
– 2. Spontaneous perspiration and/or night sweats accompanied by fear of wind and cold, a cold feeling in the low back, and frequent catching of colds due to disharmony between the constructive and the defensive. (Use stir-fried Gui zhi.)
– 3. Chest and cardiac area pain due to heart Yang deficiency and disharmony between the Qi and blood. (Use 15-30g Gui zhi. In case of very cold limbs, Fu zi can be added.)
– 4. Abdominal pain with spasms and cramps due to deficiency cold and disharmony between the Qi and blood. (Dose Bai shao:Gui zhi::2:1. Use honey mix-fried Gui zhi and wine mix-fried Bai shao.)
– 5. Pain and/or numbness of the limbs due to disharmony between the Qi and blood. (Use stir-fried Gui zhi and wine mix-fried Bai shao.)
– 6. Vomiting and weakness during pregnancy accompanied by fear of cold, lack of appetite, nausea and a weak pulse in the cubit position due to disharmony of the spleen and stomach and the constructive and defensive. (Use stir-fried Gui zhi and wine mix-fried Bai shao.)
– 7. Weakness in the elderly, during convalescence, postpartum, and post-operatively with fatigue and lack of strength, fear of wind, and slight perspiration due to disharmony between the constructive and the defensive. (Use stir-fried Gui zhi.)
• With Shi gao to clear heat, free the flow of the network vessels, stop pain, and treat heat Bi or impediment. For such indications as rheumatic pain of the heat type with redness, heat, swelling, and severe pain in the joints. (Bai Hu Gui Zhi Tang)
• With Ma huang to mutually reinforce each other’s floating and dispelling characteristics, to effectively open the pores, strongly promote perspiration, resolve the muscle layer, and scatter wind-cold of the excess type. For indications such as:
– 1. Colds, influenza with fever, fear of cold, severe shivering, absence of perspiration, headache, and general body aches caused by wind-cold of the excess type.
– 2. Rheumatic pains due to wind, cold, and dampness. (Ma huang Tang)
– 3. Cough and asthma due to wind-cold obstructing the Lung Qi. (Ma Huang Tang) It is advisable to use honey mix-fried Ma huang for cough and asthma.
Gui zhi communicates with the constructive division [Ying] where it moves fluids. It brings these fluids to the exterior where Ma huang pushes them outward forcefully.
• The fine twigs (Gui zhi jian or Gui zhi shao) are known for their powerful Qi and are very fragrant. They are more powerful (than Gui zhi) for scattering wind-cold, warming and opening the channels and vessels, and quickening the blood.
Gui zhi mu, small twigs of cinnamon from which the external bark has been removed, is less powerful than Gui zhi for resolving the exterior and inducing perspiration, but is more powerful for warming the channels and quickening the network vessels. Gui zhi mu is preferred for the treatment of joint pain and stiffness of the sinews.

Dose: 3-15g

Jing Jie – Schizonepeta flowers and herb

Nature: acrid, slightly warm

Enters: Lung, Liver

Actions: Releases the exterior by eliminating wind; stops bleeding (charred); promotes expression of rashes, alleviates itching.

Indications:
• Wind-cold or wind-heat: headache, fever, aversion to cold, lack of sweats (combine appropriately for heat or cold).
• Wind: itching, urticaria, slow skin eruption in measles.
• Has a superficial effect (to skin level).
• Carbuncles and boils when they first erupt, especially when accompanied by chills and fever.
Liu: special for skin problems, the upper body, sore throat, headache, aversion to cold.
• Diaphoretic, increases subcutaneous circulation.
Bensky/Gamble: can be used whether the disorder is hot or cold.
• Short cook.
Li: [contrary to Liu] this is a warm herb – caution with sore throat, can worsen it (Li removes Jing jie from Yin Qiao San when there is a sore throat). [My limited clinical experience seems to corroborate this idea. -PLB]
• With Fang feng – vital for opening the chest for persistent lung obstruction.
MLT: Antispasmodic, useful for rheumatism, facial paralysis, stroke symptoms, stiff neck and spine.

Dose: 3-9g
Jie Dui Tan: charred form
• Stops bleeding, promotes blood circulation, dispels blood stasis.
• For bleeding, helps the liver store blood and the spleen hold blood.
• Epistaxis, hemafecia, uterine bleeding.

Ma Huang – Ephedra (E. sinica, E. equisetina, E. intermedia) – “Hemp Yellow”

Nature: acrid, warm

Enters: Lung, Bladder

Actions: Promotes sweating (opens the pores); relieves asthma; promotes urination; disperses/moves Lung Qi and encourages it to descend.

Indications:

• Wind-cold invasion: aversion to cold, no sweats, etc. – specifically Taiyang.
• Wind-cold in the Lung obstructs Qi: cough, asthma.
• Edema with exterior syndrome (heat or cold).
• For externally-contracted or internally-generated wheezing.
Ma huang opens the pores, but does not supply the sweat (combine with Gui zhi, which reaches the heart, the mother of sweat).
• Beneficial for urinary retention due to Lung Qi deficiency, where the Lungs lack the energy to descend fluids to the bladder.
• To mitigate its diaphoretic function, combine with astringent herbs, Qi tonics, or cool herbs.
• Anti-viral (influenzas); bronchodilator; vasoconstrictor, raises blood pressure (mild but prolonged).
• Not for breathing problems due to failure of the kidneys to grasp Lung Qi.
• Traditionally prepared by decocting it first and removing the foam on the surface of the water before adding other ingredients.
• American species (Mormon Tea / Brigham Tea) may be decent, though weaker, substitutes.
MLT: Of the world’s ephedra species, Chinese has the most ephedrine and pseudoephedrine, especially between the joints of the stem. The best quality Ma huang has the joints removed.
PFGC: Shen Nung says it can break up masses and accumulations; it can reach the surface and also penetrate deeply into pockets of accumulated phlegm and coagulated blood, especially in combination with materials to eliminate masses and transform stasis
• By its entry into the Taiyang bladder, it can also enter the Shaoyin kidney and treat Shaoyin syndrome.
• Can treat pustules, skin ulcerations, stubborn skin disorders of the Yin (cold) type.
• The foam that collects on the water when Ma huang is cooked is too intense a diaphoretic and should be removed.
• People in cold areas with thick skin and muscles may need a larger dose to induce sweating.
DY: This is one of six medicinals which have been traditionally aged for the purpose of reducing secondary effects and reinforcing their therapeutic actions. Generally, the longer it is kept, the more efficient.
• The nodes of the stem (Ma huang jie) have an anti-diaphoretic action (like the root). For most effective diaphoresis, the knots should be removed.
• With Gui zhi to mutually reinforce each other’s floating and dispelling characteristics, to effectively open the pores, strongly promote perspiration, resolve the muscle layer, and scatter wind-cold of the excess type. Gui zhi communicates with the constructive division [Ying] where it moves fluids. It brings these fluids to the exterior where Ma huang pushes them outward forcefully. See Gui zhi in this category for specific indications of this combination.
CHA: (Karen S. Vaughan) Honey fried Ma huang: The high heat in frying releases the essential oils in the joints of the Ma huang which would otherwise prevent sweating. (Smashing the joints and allowing the oils to escape would have a similar effect, but without honey’s properties.) Honey frying makes Ma huang less warming (which may seem counterintuitive) because the oils are freed. (The Shang Han Lun suggests using node-free Ma huang to promote sweating.)
K&R: Sympathomimetic, diaphoretic, vasoconstrictor, bronchodilator, adrenal medulla stimulant, volumetric diuretic.
Wood, fire, metal, and water deficiency, water excess.
Also for cardiac disorders – hypotension, bradycardia.
FDA: Contraindicated in heart disease, hypertension, thyroid disease, diabetes mellitus, difficult urination with enlarged prostate, or with antidepressants
Yoga: Somalata: K-; P+; V+ (in excess)
• Powerful Kapha reducer; lymph cleanser.
Rajasic – can overstimulate the adrenals and burn out the nerves.
IBIS: Affinities: respiratory tract, urinary tract.
• Actions: Sympathomimetic, Bronchodilator, Decongestant, Central stimulant, Hypertensive, Diuretic, Sudorific, Anti-rheumatic.
• [Western] dosage: Tincture : (1:4) 2.5 ml T.I.D.; Decoction of Dried herb : 600 mg – 1500 mg per cup, 3 cups per day; Maximum Recommended Doses: UK: (Schedule III restricted): 600 mg herb single dose. USA: (FDA recommended) 8 mg single dose, 24 mg total daily as ephedrine alkaloid. Commission E: 15-30 mg single dose as ephedra alkaloid up to max. 300 mg daily as ephedrine alkaloid. Children – Not recommended under 13 years. 2 mg alkaloid /Kg body weight maximum dose.
• Internal: Asthma, hay fever, urticaria, hives, emphysema, nocturnal eneuresis, narcolepsy, febrifuge, rheumatism, myasthenia gravis, edema, rheumatic conditions.
• External: Allergic skin irritations, insect bites and stings.
• Specific Indications: Allergic rhinitis, congestion due to sinusitis, coryza or asthma.
Pharmacology:
• Ephedra is indirectly sympathomimetic, causing epinephrine release and thus non specific adrenergic receptor agonism. Ephedrine is predominantly alpha adrenergic, pseudoephedrine is predominantly beta adrenergic (Mills, 1991). Ephedrine is well absorbed by the oral route, crosses the blood brain barrier easily, and has a half life much longer than epinephrine being resistant to MAO and COMT degradation; excretion is urinary. The whole herb is not identical to isolated ephedrine because of the pharmacodynamics of pseudoephedrine and other components; in addition there are pharmacokinetic differences between the whole herb and isolated ephedrine (Mills, 1991; White, 1997; Gurley, 1998).
• Alpha and beta adrenomimetic effects: peripheral vasoconstriction, skeletal muscle vasodilation, positive inotropism, potentially hypertensive, sudorific, tachycardic, bronchodilator, mydriatic, urogenital tract stimulant and relaxant, decreases visceral muscle motility, increases viceral sphincter tone lipolytic, thermogenetic, hyperglycemic, diuretic.
• Central stimulation: Increases arousal and wakefulness.
• Motor end plate actions: Ephedrine modulates skeletal muscle motor end plate activity in rat models of myasthenia gravis (Sieb, 1993., Molenaar, 1993)
• Complement inhibition: Aqueous extracts of Ephedra inhibit complement activation at C2 and C9 (Ling, 1995).
• Inhibition of 3’5’cAMP Phosphodiesterase: Whole Ephedra extracts inhibit PDE in vitro, but isolated ephedrine did not inhibit PDE. (Nikaido, 1990, 1992).
• Reports of Ephedra whole herb toxicity in therapeutic dose ranges are absent from the medical literature. Numerous references to ephedrine (isolated alkaloid) toxicity exist. Ma Huang OTC supplements are often cited in toxicity reports without analysis of dose or alkaloid content. Ephedra is not used as an isolated herb or supplement by clinical herbalists of Western or Traditional Chinese schools, but is always used in combination with other herbs.
• Excessive consumption of ephedrine causes typical side effects of sympathetic hyperstimulation including headaches, nausea, dizziness, vomiting, palpitations, tachycardia, insomnia, tremor, anxiety. These effects are less noticable in consumption of the whole herb, and it has been suggested that the other constituents may modify the effects of the ephedrine alkaloids (Mills, 1991) .
• Nephrolithiasis has recently been associated with both ephedrine and Ma Huang usage (Powell,1998) .
• Contraindicated in hypertension due to vasoconstrictive and inotropic actions. Hypertensive effects of ephedrine in whole herb modulated by pseudoephedrine beta adrenergic effects causing muscle bed vasodilation.
• Contraindicated in hyperthyroidism: due to sympathetic induced increase in metabolic rate.
• Contraindicated in anxiety states: due to central stimulatory effects.
• Contraindicated in pregnancy: due to uterine stimulatory action of ephedrine and potential mutagenicity of byproducts.
• Contraindicated in Benign Prostatic Hypertrophy: due to net adrenergic effects on bladder causing urinary retention.
Drug interactions:
• Sympathomimetic effects could interact with MAOI therapy to cause potentially harmful elevation of catecholamine levels.
• Increased norepinephrine levels may reduce effectiveness of beta-blocker therapy.
• Ephedrine containing preparations are banned by Olympic and other sporting authorities.
Notes:
• Related Species: E. sinica is the principal herb of commerce; the related species E. equisitina, E. intermedia, E. distachya, E. geradiana all contain ephedra alkaloids, in varying distribution profiles (Zhang,1989). Several species of Ephedra are native to the South Western USA, including E. nevadensis, E. viridis. These species, commonly known as Mormon Tea or Mexican Tea have either insignificant traces or no detectable alkaloids (Moore, 1993).
• Traditional Chinese Medicinal Uses: Ma Huang has been used for over 5000 years in China. Ma Huang is never given alone in Chinese medicine, but always used in formulae combined with other herbs that modulate its stimulant effects without altering its actions on the lungs and kidneys. The crude herb may also be treated before use (by boiling in water or cooking with honey) to change its characteristics. Its principal uses in TCM are to disperse external wind, and aid movement of Lung qi. It is also taken for chills, fevers and coughs, and in combination with Rehemannia glutinosa as a kidney yin deficiency tonic. In Chinese medicine, the root is also used – its therapeutic effects being almost opposite to the stem e.g. hypotensive as opposed to hypertensive (Hikono,1983).
• Ephedra and its alkaloids have gained widespread popularity among the sports and body-building communities for weight reduction. The combination of ephedrine with caffeine (E.C.), and of both with aspirin (E.C.A.) is used by body builders in combination with caloric restriction to “cut” fat. This practice and popular OTC “weight loss” and “natural speed” products, based either on Ephedra herb or more usually on isolated ephedrine alkaloids have attracted considerable bad press in recent years. The FDA responded by issuing ultra-conservative dosage guidelines for Ephedra herbal products, expressed in terms of total ephedrine alkaloid maximum recommended doses. (Since then, this herb and its derivatives have been essentially banned, due to their use in the manufacture of crystal methamphetamine. Even pseudoephedrine products are now controlled.) The retail and MLM market is still replete with products purporting to be legal or natural speed and “natural” weight loss agents that contain variable amounts of Ephedra alkaloids or synthetic ephedrine and which will likely continue to be subject to consumer abuse and potential adverse reactions.

Dose: 3-9g

Qiang Huo – Notopterygium root

Nature: acrid, bitter, warm

Enters: Bladder, Kidney

Actions: Releases the exterior and dispersing cold; eliminates wind; powerfully eliminates (external) dampness; unblocks obstruction to alleviate pain; guides to the Taiyang and Du Mai.

Indications:
• Exterior obstruction (especially with dampness) causing pain, aversion to cold, fever, aches over the body and head, general feeling of heaviness, sleepiness, headache at the vertex or occiput.
• Wind-cold-damp: soreness and pain (Bi) over the limbs (especially upper limbs), shoulders, back.
• Reaches deeper than Jing jie and Fang feng: penetrates to bones and tendons.
• Compared to Du huo, Qiang huo is used more for the upper body while Du huo is used more for the lower body.
• Warm, dry, ascending, dispersing nature.
DY: Powerful in action; tropism: the upper part of the body, occiput, nape of the neck, shoulders, upper limbs, and Taiyang.
Qiang huo has a more powerful action than Du huo. Its nature is upbearing, draining, and vigorous. The ancients said that Qiang huo has a “masculine dispersing Qi.”
• With Du huo to dispel wind, cold, dampness, and treat Bi over the whole body. For indications such as:
– 1. Moving rheumatic pains all over the body. (Juan Bi Tang)
– 2. Common cold with fever, back pain, and joint pain due to wind, cold, and dampness. (Qiang Huo Sheng Shi Tang)
– 3. Joint running wind due to wind, cold, and dampness penetrating the channels and network vessels. Li jie feng or joint running wind refers to acute arthralgia which is severe and movable with loss of joint mobility, swelling, and intense joint pain which is worse at night. This affection can transform itself into heat and then cause redness, pain, swelling, and heat.

Dose: 6-15g

Sheng Jiang – Fresh Ginger rhizome

Nature: acrid, slightly warm

Enters: Lung, Spleen, Stomach

Actions: Releases exterior syndromes by promoting sweats; stops vomiting by warming the middle Jiao; stops coughing by warming the Lungs; eliminates or reduces toxicity from crabs, fish, shrimp, and some herbs; adjusts Ying and Wei Qi.

Indications:
• Cold in the stomach: vomiting.
• Wind-cold: fever, aversion to cold, headache, nasal congestion.
• Wind-cold or chronic Lung phlegm disorder: cough.
• Cook with brown sugar for mild wind-cold in children.
• Good for motion sickness, helps the nausea of chemotherapy.
• Beneficial in acute bacillary dysentery.
• Weaker than Zi su ye at releasing the exterior/promoting sweating.
• This herb is mainly used to assist.
• Topical: slices over affected testicle in acute orchitis (when no lesions).
• Spasms, sprains, pain: apply ginger tea
• Raises blood pressure (an average of 11.2/14 in adults in one study).
• Ayurvedic uses: see dry ginger – Gan jiang.
• The skin of the ginger rhizome – Sheng jiang pi – additionally can promote urination and reduce edema.
• Anti-emetic effect: there are many studies, most of which find that ginger, in doses ranging from 3-20 grams per day, alleviates nausea. Much of the research has focused specifically on nausea induced by chemotherapy, with some studies looking at motion sickness and morning sickness. While I have included this comment under “fresh ginger,” many studies used dry ginger in capsules.
• Anti-inflammatory: ginger contains anti-inflammatory compounds, particularly gingerols, which have been shown in studies to mildly reduce the pain of osteoarthritis. Gingerols don’t appear to be especially potent, especially compared to pharmaceutical anti-inflammatories, but may be more effective in synergy with other anti-inflammatory herbs.
• Gingerols have demonstrated anti-cancer properties against many different cancers, though research has been mainly in vitro, and we’re not yet at a practical application of ginger for cancer.
• Ginger may produce side effects in some people, and especially at higher doses: heartburn, dizziness, diarrhea, headache, and possibly even nausea.
K&R: (fresh and/or dry – not indicated) Eupeptic, carminative, febrifuge, stimulant, antiphlogistic, antiprostaglandin, sudorific, stimulates circulation and sympathetic nervous system, increases salivary and gastric secretions, strengthens peristalsis of stomach and intestines, accelerates transport through alimentary canal and has general calming effect, stimulates appetite, slight detoxifying effect, anti-ulcerative, especially for ulcers from excess HCl.
• Metal, water, and earth deficiency.
Metal: respiratory infection, bronchitis, flu, bronchorrhea, pulmonary congestion, fever.
Earth: anorexia, glairy diarrhea, immune deficiency, leukopenia.
Water: impotence, UTI, glomerulonephritis.
• Also for hiccups, abdominal pain, diarrhea, gas, amenorrhea from insufficient circulation.
• For motion sickness: can work as well as or better than Dramamine.
DY: “Sheng jiang” refers not simply to raw ginger – it must be fresh and young.
• With Ban xia to transform phlegm, downbear counterflow, harmonize the stomach, and stop vomiting. For such indications as:
– 1. Nausea, vomiting with not thirst and slimy tongue fur due to phlegm-dampness stagnating in the middle burner. (Xiao Ban Xia Tang) Ginger-processed Ban xia should be used.
– 2. Enduring cough with white, watery, and profuse phlegm. Use lime-processed Ban xia.
Sheng jiang is renowned for effectively treating vomiting. It can be used for all types of vomiting, even in the case of stomach heat, if it is combined with other medicinals related to the nature of the imbalance. It is traditionally said, “Sheng jiang is a sagelike medicinal for vomiting.”
• Use it with bitter medicinals when these would otherwise cause nausea. In these cases, Sheng jiang is directly integrated into the decoction or chewed immediately after swallowing the liquid. This often is sufficient to calm the most stubborn patient.
• With Da zao to move the defensive Qi, nourish the constructive Qi, harmonize the constructive and defensive, fortify the spleen, and harmonize the middle burner. For indications such as:
– 1. Perspiration, fear of wind, and fever due to disharmony between the constructive and defensive Qi. (Gui Zhi Tang)
– 2. Fatigue, lack of strength, abdominal pain, and lack of appetite due to disharmony between the constructive and defensive Qi. (Xiao Jian Zhong Tang)
– This pair helps insure the proper assimilation of the active principles of other medicinal substances. These are the two main harmonizing herbs in Chinese medicine.

Dose: 3-9g

Xiang Ru – Elscholtzia – Aromatic Madder – “Fragrant Soft Herb”

Nature: acrid, slightly warm

Enters: Lung, Stomach

Actions: Releases exterior syndromes by promoting sweating (strong); expels summer-heat; adjusts function of the stomach to resolve dampness; promotes urination, relieves edema; reduces swelling.

Indications:
• Wind-cold or summer-heat with dampness: fever, aversion to cold, headache, abdominal pain, vomiting, lack of sweats, chills, body aches, diarrhea.
• Edema with scanty urination, urinary difficulty, especially when associated with an exterior pattern.
• Simultaneously expels summer-heat from the exterior and transforms turbid dampness in the interior.
• Mainly used in summer.
• For exterior disorders, cook only a short time.
• For edema, cook a long time into a concentrated decoction.
• So effective for summer-heat with dampness that it is sometimes called the “summertime Ma huang.”
• May cause vomiting if taken hot. Take at a room temperature or add Huang qin or Huang lian to reduce this effect.

Dose: 3-9g

Xin Yi Hua – Magnolia flower

Nature: acrid, warm

Enters: Lung, Stomach

Actions: Disperses wind-cold; opens the nose.

Indications:
• Any nasal or sinus conditions: nasal congestion or obstruction, nasal discharge, loss of sense of smell, related headache.
• Wind-cold or wind-heat: key herb (first choice) for sinusitis and rhinitis.
• Stronger than Cang er zi to open the nose.
• Antifungal.
• The hairs can irritate the throat (use a tea bag or grind to a powder).
• This herb has also been prepared as an ointment and an aerosol for local application: when applied to nasal mucosa, Xin yi hua causes a reduction in secretions.
DY: Often combined with Cang er zi. See Cang er zi in this category for the properties and indications of this combination.

Dose: 3-9g

Notes on This Category

• For wind-heat, herbs from this category are often combined with herbs to clear heat-toxicity, since toxicity commonly results when heat is extreme.
• “Liang E Bing Fu“: Too many acrid, cool herbs will simply suppress wind-heat. They freeze the surface and wind-heat cannot leave the body. Add one or two acrid, warm herbs to formulas for wind-heat (i.e. 80% cool herbs, 20% warm herbs).
• Use caution when there is profuse sweating or injury of body fluids, and with patients with carbuncles, boils, urinary tract infection, or a history of heavy bleeding.
• Since the dispersing effect of some of the more aromatic herbs in this category is dependent on their volatile oils, they are often decocted only for a short time, or they are just infused (not exposed to a heat source, simply allowed to steep in water that has been brought to a boil).

Bo He – Chinese Field Mint

Nature: acrid, cool

Enters: Liver, Lung

Actions: Disperses wind-heat; eases the head, eyes and throat; expresses skin eruptions; promotes Qi circulation on the surface and frees liver Qi.

Indications:
• Wind-heat: headache, fever, slight aversion to cold, sore throat, red eyes, cough, nasal congestion.
• Liver Qi stagnation: distention, pain or pressure in the chest, costal region, or hypochondrium, emotional instability, gynecological problems.
• Wind-heat: slow skin eruption in early-stage measles, or other early-stage rashes.
• Add to a decoction in the last five minutes of cooking.
HF: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas.
Li Dong Yuan: Upbears Yang Qi.
Li: Can be warming in a large dose.
Yoga: Phudina: P, K-; V+ (in excess)
Sattvic herb, very ethereal: soothing, cooling, clarifying, expanding.
• Relieves tension, congestion; mild; harmonizer.
• Pungent/cooling (slightly)/pungent.
• Affects respiratory, nervous, digestive, and circulatory systems.
• Stimulant, diaphoretic, carminative, nervine, analgesic.
• Same indications as TCM plus earache, dysmenorrhea.
MLT: Similar to Lemon Balm and Spearmint (these herbs can be substituted).
• Do not boil. Infuse in the boiled water only after the rest of the decoction is prepared.

Dose: 1.5-6g

JC: on Spearmint (likely pretty similar to Bo he):
• Diaphoretic (gentle), diuretic (lithotriptic), stimulant, carminative, antispasmodic, aromatic, nervine (sedative), condiment, nephritic, anti-emetic.
• Beneficial to the kidneys and bladder as a diuretic, especially for suppressed, painful, or scalding urination, and bladder/kidney inflammation.
• Soothing and quieting to the nerves and stomach.
• Colic, flatulence, dyspepsia, spasms, dropsy, nausea, vomiting, gravel in bladder, hemorrhoids (shallow enema).
• Ginger intensifies and accelerates its action.
• Vomiting and nausea of pregnancy: 14g spearmint, 2 teaspoons cloves (ding xiang), 2 teaspoons cinnamon (rou gui), 2 teaspoons rhubarb (da huang). Infuse in 1 pint boiled water, cover 20 minutes, strain, take 3-4 tablespoons every 30 minutes.
PLB: Peppermint (the most pungent mint) is, overall, stronger/sharper than Spearmint, and is probably less similar to Bo he.
BII: For irritable bowel syndrome, GB disease (studies used enteric coated capsules of peppermint oil).
• Not for heartburn or esophageal reflux as it relaxes the esophageal (cardiac) sphincter (use licorice/DGL instead).

Chai Hu – Bupleurum root – “Kindling of the Barbarians”

Nature: bitter, acrid, slightly cold

Enters: Liver, Gallbladder, San Jiao, Pericardium

Actions: Frees the liver Qi; disperses pathological factors in the half-interior, half-exterior; lifts spleen Yang Qi; reduces fever; can both lift and descend (acrid and bitter).

Indications:
Shaoyang syndrome: alternating fever and chills, distended chest and hypochondrium, bitter taste in the mouth, flank pain, irritability, vomiting, dry throat, dizziness.
• Liver Qi stagnation: distended hypochondrium, costal pain, headache, irregular menses, dysmenorrhea, dizziness, vertigo, stifling sensation in the chest, flank pain, emotional instability.
• Spleen Qi sinking: prolapsed rectum or uterus, diarrhea, hemorrhoids, shortness of breath.
• Spleen/liver disharmony: epigastric and flank pain, stifling sensation in the chest, abdominal bloating, nausea, indigestion, bloating.
• Some say Chai hu damages the Yin, since it is bitter and drying (often combined with Bai shao to counteract its drying nature).
• Contraindicated in liver Yang rising due to liver/kidney Yin deficiency.
• Antipyretic; some antibiotic/bacteriostatic effects; tranquilizer; anti-tussive.
• Used to treat malarial disorders.
• Occasionally can cause nausea or vomiting (should use a small dose in this case).
Chinensis species (hard, Northern) (Bei/Ying chai hu): better for harmonizing the Shaoyang and clearing heat and wind-heat.
Scorzoneraefolium species (soft, Southern) (Nan/Ruan chai hu): better for spreading liver Qi, resolving depression, and relieving constraint.
Jin: Safe in pregnancy in moderate dose (to 4.5g).
MLT: Some patients are sensitive to Chai hu. Some believe it “consumes the Yin.” Despite its recommendation in the Shan Han Lun, many doctors avoid this herb.
• With blood deficiency, always combine it with Dang gui and/or Gou qi zi.
PFGC: Can purge heat in the uterus; can resolve blood heat; disperses exuberant gallbladder fire.
• Should be used to ascend Shaoyang pathogens to push them over and beyond the diaphragm, forcing them up and out.
• In large doses, it is diaphoretic, but this results in out-of-hand momentum and weakening of its uplifting force.
• Can facilitate smooth bowel movements and can foster proper urination – because uninhibited urination is linked to proper function of the san jiao – Qi dynamics of the san jiao are such that Qi descends only if it is allowed to rise first.
• Use in pre- and post-partum disorders, eruption of macules in children, consumptive fevers, carbuncles, furuncles, all malaria.
• Food accumulation: can move wood Qi to course earth.
• Alternating hot and cold are not a necessary symptom to prescribe Chai hu – it is enough to know the patient has an exterior affliction with nausea or vomiting or frequently spitting sticky saliva – this is sufficient evidence that the disease is in the Shaoyang.
HF: An important herb in anti-Gu therapy to move Qi (Xing Qi) and break accumulation (Po Ji).
DY: Drains the liver and resolves depression; harmonizes the Shaoyang; harmonizes the liver and spleen; abates heat; upbears clear Yang; frees the flow of Qi on the left side of the body.
• With Bai shao to drain the liver without damaging liver Yin, nourish the liver without causing liver depression Qi stagnation, regulate the spleen, stop pain effectively, harmonize the interior and exterior, and constrain Yin while upbearing Yang. For such indications as:
– 1. Liver depression Qi stagnation causing disharmony between Qi and blood.
– 2. Vertigo, unclear vision, chest and lateral costal oppression, pain, and distention due to liver depression Qi stagnation or to disharmony between the exterior and interior.
– 3. Menstrual irregularities, dysmenorrhea, breast distention, low-grade fever during the menses, premenstrual syndrome, and fibrocystic breasts, all caused by liver depression Qi stagnation or disharmony between the liver and spleen.
• The combination of Bai shao and Chai hu is effective for the treatment of liver and digestive problems caused by liver depression Qi stagnation or liver-spleen or liver-stomach disharmony, such as subacute or chronic hepatitis, hepatomegaly, cholecystitis, gallstones, enteritis, and colitis.
• With Huang qin to harmonize the interior with the exterior, the Shaoyang, and liver and gallbladder. Together, they also clear the liver and resolve depression as well as clear and eliminate dampness and heat, particularly in the liver and gallbladder. Chai hu dispels evils (heat) limited to the superficial part of the Shaoyang while Huang qin drains evil heat limited to the internal part of the Shaoyang. For indications such as:
– 1. Alternating fever and chills, a bitter taste in the mouth, dry throat, pain and fullness in the chest and lateral costal regions, nausea, and lack of appetite due to a Shaoyang pattern. (Xiao Chai Hu Tang)
– 2. Malaria due to a Shaoyang pattern.
– 3. Liver depression transforming into fire.
– This combination is remarkably effective for hepato-biliary disorders, such as acute or chronic hepatitis, biliary lithiasis, cholecystitis, and hepatomegaly due to liver-gallbladder heat.
• With Sheng ma for mutual reinforcement, to upbear liver, stomach, and spleen Yang Qi. These two herbs alone don’t raise the Qi efficiently. They must be combined with Ren shen, Huang qi, and Bai zhu to be really effective for this purpose, because one cannot raise what is lacking. Huang qi does appear to upbear the Qi, but not for long. When Chai hu, Sheng ma, and Huang qi are combined, they raise the Qi effectively, and for long periods of time.
For indications such as:
– 1. Uterine prolapse, rectal prolapse, gastric ptosis due to central Qi fall. (Bu Zong Yi Qi Tang)
– 2. Metrorrhagia and abnormal vaginal discharge due to central Qi fall.
– 3. Chronic diarrhea or chronic dysentery due to central Qi fall. (Bu Zhong Yi Qi Tang)
– 4. Shortness of breath and dyspnea with feeling of oppression and downward falling of Lungs due to Qi fall. (Sheng Xian Tang)
– For all the above indications, Sheng ma should be honey mix-fried and Chai hu should be stir-fried until scorched.
– In all the above cases, a small dosage of the two herbs is sufficient (i.e. 3-5g). However, a larger dose of Sheng ma (9-15g) can be used if one wants to simultaneously clear Yin fire due to spleen deficiency from the head and face.
Chai hu is a messenger herb which guides the action of other medicinal substances toward the liver and gallbladder channels, toward the upper part of the body (head and face), along the liver channel pathway (internally) and the gallbladder channel pathway (externally), and toward the lateral costal region.
Chai hu in high dosage (10-18g) resolves the exterior, abates heat, and harmonizes the Shaoyang. In small dosage (2-4g), it upbears Yang Qi. In an average dosage (6-8g), it courses the liver, rectifies the Qi, and resolves depression.
• When pain is predominant, vinegar mix-fried Chai hu is best.
• In cases of liver-spleen disharmony, stir-fried Chai hu should be used.

Dose: 3-12g

Chan Tui – Cicada Molt (skin)

Nature: sweet, cold

Enters: Lung, Liver

Actions: Disperses wind-heat; expresses skin eruptions; promotes vision by removing nebulas; relieves convulsions by subduing liver wind (large dose); strongly clears heat from the nose, eyes, and throat.

Indications:
• Wind-heat: loss of voice, sore throat, cough, hoarseness, or fever, headache.
• Wind-heat or early measles: incomplete expression of skin rash.
• Liver wind-heat: red eyes, tears, nebulas, conjunctivitis, painful eyes, blurry vision.
• Liver wind-heat: childhood febrile disease, morbid night crying in babies, spasms, convulsions, delirium, night terrors; tetanus.
• Doctrine of signatures: skin treats skin; big eyes indicate affinity for eyes/liver; cicadas are silent at night – for calming children at night.
Hsu: Anticonvulsant; decreases muscle tremors caused by nicotine.
DY: Disinhibits the throat; diffuses the portals of the Lungs and increases the voice.
• One of few herbs in the materia medica which calms the liver and settles convulsions and is also non-toxic, even at high doses of up to 30g/day (unlike scorpion and centipede). For this reason, it is good for children.
• Vexation, agitation, insomnia, night crying, night fears, nightmares, clonic convulsions, epilepsy.
• With Shi chang pu to effectively rouse the spirit and open the portals. For vertigo, tinnitus, and deafness due to obstruction of the portals.

Dose: 3-12g

Dan Dou Chi – Prepared Soybean

Nature: acrid, sweet, slightly bitter, cold

Enters: Lung, Stomach

Actions: Relieves exterior syndromes; relieves restlessness; clears heat.

Indications:
• Wind-heat or wind-cold: fever, aversion to cold, headache (can be used for either hot or cold invasion, usually for early stage).
• Febrile disease causing stagnant heat in the chest: restlessness, insomnia, irritability, stifling sensation in the chest (Dan dou chi also reaches the heart) – combine with Zhi zi.
• Because of its mild character, is also appropriate for Yin deficiency with a superimposed exterior disorder.
• Is treated either with Ma huang or Zi su ye (more warming effect) or Sang ye or Qing hao (more cooling effect).
MLT: Good for kids (ok taste, nutritive).
• This and all soybeans contain genistein – occupies estrogen binding sites and seems to inhibit development of estrogen-sensitive tumors.
DY: Promotes perspiration; diffuses and out-thrusts external evils from the exterior.
• With Zhi zi, the two herbs unite to form the clearing and diffusing and out-thrusting method to eliminate evils from the exterior and interior. Together, they effectively promote perspiration, drain evils from the exterior, clear and out-thrust heat from the interior, and eliminate vexation due to full heat. For indications such as:
– 1. Vexation and agitation, insomnia, and irritability during or after a warm disease. (Zhi Zi Chi Tang) Use stir-fried Dan dou chi.
– 2. External contraction of wind-heat or a febrile disease.
Qing dou chi is cold, and clears heat and eliminates vexation
Wen dou chi is warm and is superior for resolving the exterior and promoting diaphoresis. Although it is warm in nature, it is used in and preferred for wind-heat affections.

Dose: 9-15g

Fu Ping – Duckweed – Spirodela

Nature: acrid, cold

Enters: Bladder, Lung

Actions: Releases the exterior; unblocks the muscle level; vents rashes; dispels water, reduces swelling.

Indications:
• Exterior heat: head and body aches.
• Hastens full expression of measles and other exanthemas and wind rashes and thereby hastens resolution of the disease.
• Hot, superficial edema, especially when affecting the upper body and when accompanied by urinary difficulty.
• One of few cool herbs that is a strong diaphoretic.
• Doctrine of signatures: The herb is very light, grows on the surface of water. This indicates its affinity for the surface/skin and its ability to release superficial water (edema, sweat).
• Topical: also used as a wash for rashes.
• Often used alone.
MLT: Diuretic, diaphoretic.

Dose: 3-6g (to 9g in severe cases)

Ge Gen – Pueraria lobata root – Kudzu

Nature: acrid, sweet, cold

Enters: Spleen, Stomach

Actions: Relaxes muscles by promoting sweats and expelling EPIs; lifts spleen Qi and Yang; clears heat; generates body fluids; supports detoxification and withdrawal from alcohol; benefits the skin; .

Indications:
• Wind-heat or wind-cold (lodges in the muscles): stiff neck, occiput, or upper back, fever, headache, no sweating.
• Early-stage measles: slow eruption of skin, fever, aversion to cold.
• Spleen Qi deficiency or damp-heat: diarrhea (when due to deficiency, combine with tonics).
• Injury of body fluids by heat in febrile disease: restlessness and thirst.
• Stomach heat: thirst.
• Lowers BP, treats headache, dizziness, tinnitus, paresthesias due to HTN.
• Also for sudden deafness, ear infections.
• Eases alcohol withdrawal and hangover.
• Lowers blood sugar/treats diabetes.
• The flower, Ge Hua, relieves hangover and stops bleeding. A study showed it has anti-androgenic effects when applied to the scalp to treat baldness / alopecia (androgenic / “male-pattern” type).

Guohui Liu: special for tendinitis.
• General analgesic for a variety of pains.
• To lift spleen Qi, roast with wheat bran until the Ge gen turns yellow. This form is less cooling and is superior for diarrhea due to deficiency.
Yoga: Sweet/cooling/sweet; P, V-; K+
• Tonic, diaphoretic, diuretic.
MLT: Demulcent and soothing to the stomach and intestines.
• Has an upward, antispasmodic property.
Hsu: Anticonvulsant, follicular hormone effect, dilates coronary arteries, improves cerebral blood flow in hypertensive patients.
DY: Resolves the muscle aspect; eliminates heat; engenders fluids and stops thirst; tends to reach evils horizontally and, therefore, out-thrusts rashes on the back and the middle part of the body.
• Marked vasodilatory effect, used for hypertension, hypercholesterolemia, coronary disease, angina pectoris, headaches and painful tension in the cervical area due to hypertension.
• With Sheng ma to resolve the exterior and muscle aspect, clear heat, resolve toxins, and out-thrust rashes over the whole body. For indications such as:
– 1. Skin rashes which have difficulty surfacing, accompanied by headache and fever due to an exterior pattern. (Sheng Ma Ge Gen Tang)
– 2. Measles in the initial stage with eruptions which have difficulty surfacing, and fever sometimes accompanied by lack of perspiration or perspiration which has difficulty coming out due to an exterior pattern. (Xuan Fu Jie Bao Tang)
• While Sheng ma is used for all forms of Qi sinking, Ge gen is only used for diarrhea. It treats diarrhea of either the deficient type (i.e. spleen deficiency) or excess type (i.e. damp-heat). For this, roasted Ge gen should be used.

Study: The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.

ITM: Pueraria: Source of Important Isoflavones, by Subhuti Dharmananda, Ph.D., Director, Institute for Traditional Medicine, Portland, Oregon

Background: the herb and its constituents

Pueraria (gegen), the root of Pueraria lobata, is a commonly used herb in Chinese medicine.  It is perhaps better known by its Japanese name: kudzu.   It is a fast growing vine that can extend a foot in length each day during the warm season.  Its root is also fast growing, typically reaching 50 pounds or more, and can attain a weight of 400 pounds (about 2/3 of it is water).   Aside from the use of pueraria as an ingredient in traditional Chinese medicine formulas, mainly those from the ancient Shanghan Lun, it is the source of a food ingredient widely used in Japan: its starch.  Kudzu starch has a mild taste that doesn’t conflict with delicate and subtle flavors; it creates a smooth consistency; and it crisps well when used as a coating for deep fried foods.  Before isolating the starch (which is 99.6% starch with about 0.4% water), the whole roots also have a small amount of protein and are a reasonably good source of calcium, magnesium, iron, potassium, and zinc when compared to starchy foods such as wheat and sorghum.

Pueraria has one major medicinal active component group: isoflavones that are often simply designated as puerarin, which is its main ingredient.  Although several isoflavones have been isolated and characterized, there are five principal ones: puerarin, methylpuerarin, daidzein, daidzin, and daidzein glucopyranoside.  Both daidzein and daidzin are also found in soy beans, which are known for their content of two other isoflavones, genistein and genistin (these isoflavones appear to be primarily responsible for soy’s benefits in alleviating menopausal symptoms; pueraria contains little of these two components).  The total isoflavone content of the dried pueraria root slices generally is typically around 1%, and may reach 2%.   By contrast, the main dietary source of isoflavones, soybeans, usually do not exceed 0.6% isoflavones and more typically contain about 0.3% of this component.  Isoflavones are almost exclusively found in the Fabaceae Family, including the Chinese herbs pueraria, soja (soybeans), astragalus, licorice, sophora, and millettia.

The pueraria isoflavones were intensively researched in China during the 1970’s, and developed into a drug-like product that is used for circulatory disorders.  The tablet or injection (given as IV drip) of concentrated pueraria isoflavones is used to treat dizziness, headaches, neck pain, sudden deafness, glaucoma, diabetic retinopathy and hearing loss, angina, heart attack, myocarditis, and symptoms of hypertension (1,2).  More recently, pueraria isoflavones have been examined for neuroprotective effects; as an example, it was indicated that administration of aspirin plus puerarin after a stroke had improved neurological function (3).  Laboratory animal investigation suggests that puerarin may help reduce glutamate damage to axons (4).  The uses of pueraria and its isoflavones are somewhat like those of ginkgo leaf flavonoids, crataegus flavonoids, and hippophae (sea buckthorn) flavonoids; the first is known for promoting circulation to the brain and the latter two are used for promoting cardiac circulation.

Dosage and Effect
Using the appropriate dosage of the crude herb, as indicated in traditional texts, can be elaborated from work done with isolated active components in a standard dosage form.  As examples of clinical applications (5), pueraria flavones were given in tablets at a dose of 30–40 mg each time, three times daily (total daily dose is 90–120 mg) to 191 patients with coronary heart disease and angina pectoris; in the treatment of hypertension, 50 mg of pueraria flavones given twice per day (total daily dose is 100 mg) for several weeks; similarly, hypertensive patients suffering from angina were given a daily dose of pueraria flavones at 150 mg/day.   From a survey of such applications for the tablets, the maximum daily dose recommended appears to be 300 mg/day.  However, this upper level is apparently not because of toxicity, but simply an amount that was indicated as effective for the particular applications.  Recently, work done with puerarin injection has involved 400 mg for a single injection treating diabetic retinopathy (6) and 500 mg in a single injection for heart attack patients (7).

At a maximum level of 2% isoflavones in the dried pueraria roots, to get a dosage in the range of about 100–500 mg of this component, one would use 5–25 grams in decoction.  However, the level of isoflavones is more typically only about 1%, so that a dose of 10–50 grams would be more suitable.  Since the higher dosages are given by injection for serious and acute conditions, the suggested decoction range for most applications would be 10–30 grams of dried root for a one day supply.   In a report on the treatment of diabetic hearing loss (8), the treatment group received a decoction for which the basic recipe included pueraria at 30 grams per day.

The Materia Medica guides published in China, dosage recommendations range from 5–24 grams in decoction, which is thus on the low side, but when the herb is blended in formulas, as is common, additional flavonoids are usually obtained from one or more of the other ingredients.   The low doses of pueraria root (e.g., 3-9 grams) as used in some large traditional formulas may have limited effect.  It is possible that when combined with licorice root (which is common in these formulations), the isoflavone components of these two herbs work together to alleviate inflammation, thus allowing the low dose of pueraria to contribute to the action of the formula.   A good summary suggestion is found in Oriental Materia Medica (9), where the recommended dosage range for pueraria roots in decoction is 6–24 grams, and the recommended dosage of the pueraria flavonoid is 100–300 mg/day.

The herb has very low toxicity, as demonstrated by the fact that the isoflavone extract of pueraria has even been used as an IV drip without reported adverse effects.   The authors of a report (10) on use of puerarin IV drip for heart disease patients concluded: “Puerarin is a safe and effective drug in treating patients with unstable angina and worth spreading in clinical usage.”  The authors of a review of pueraria flavonoids (11), based on work from several institutes in Beijing and Chengdu, stated that they “recently prepared [puerarin] in an 80+% concentration that shows little toxicity, benefits cardio-cerebro vascular disease, and has good absorption when taken orally.  It has passed pre-clinical examination for new drugs in accordance with criteria established by the Health Ministry of the People’s Republic of China, and is presently in clinical trials.”

Pueraria isoflavones are rapidly absorbed from the GI tract, but are also rapidly eliminated (12).  This high turn-over indicates the need for frequent dosing when using the oral form at moderate dosage, such as three times a day, to maintain significant blood levels for the desired effects on circulation.

Conditions determining what form to use:

A limiting factor in use of high dosage pueraria in decoctions is that the starch turns the decoction quite thick, especially if it is allowed to cool.  In China, because of the availability of puerarin in pill form, this herb is not often included in decoctions.  The change in practice may have come also as a result of recognizing the need for higher dosage and the shift of applications from alleviating symptoms of the common cold (as fit some of the early concepts of its use) to treating serious cardiovascular diseases.

In sum, China’s use of pueraria in recent years is tending towards less frequent administration in traditional style decoction formulas (or dried decoctions), relying more heavily on the form of concentrated extracts of the isoflavone fraction taken in daily doses of 100–300 mg puerarin per day orally or by IV drip  with doses up to 500 mg.  The herb can still be utilized in traditional decoction formulas with good effect especially if incorporated at a dose of about 15–18 grams/day (about 3.0-3.6 grams of dried decoction).  The isoflavones are the key ingredient of pueraria roots that influences the determination of proper dosage.

July 2010
REFERENCES

  1. Yue HW and Hu XQ, The medical value of radix pueraria and puerarin in treating diseases of the cardiovascular system, Chinese Journal of Integrated Traditional and Western Medicine 1997; 3(3):234-238.
  2. Lai XL and Tang B, Recent advances in the experimental study and clinical application of Pueraria lobata, China Journal of Chinese Materia Medica 1989; 14(5): 308-311, 277.
  3. Hu HT, Fen F, and Ding MP, Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction [in Chinese], Journal of Chinese Herb Drugs 2008; 33(23): 2827–2829
  4. Zhou J, et.al., Puerarin attenuates glutamate-induced neurofilament axonal transport impairment, Journal of  Ethnopharmacology 2010 Aug 18. [Epub ahead of print]
  5. Chang HM and But PPH (eds.), Pharmacology and Applications of Chinese Materia Medica, 1986 World Scientific, Singapore.
  6. Ren P, Hu H, and Zhang R, Observation on efficacy of puerarin in treating diabetic retinopathy, Chinese Journal of Integrated Chinese and Western Medicine 2000; 20(8): 574–576.
  7. Xiao LZ, et.al., Study on the effect and mechanism of puerarin on the size of infarction in patients with acute myocardial infarction, Chinese Journal of Integrated Chinese and Western Medicine 2004; 24(9): 790–792.
  8. 8. Li RY, et.al., TCM Treatment of diabetic hearing loss, Journal of Traditional Chinese Medicine   2000; 20(3): 176–179.
  9. Hsu HY, et.al., Oriental Materia Medica: A Concise Guide, 1986 Oriental Healing Arts Institute, Long Beach, CA.
  10. Zhao ZM, et.al., Clinical study of puerarin in treatment of patients with unstable angina, Chinese Journal of Integrated Traditional and Western Medicine 1999; 5(4): 254–256.
  11. Du LJ, et.al., Drug properties of pueraria flavonoid based on pharmacological action, International Journal of Oriental Medicine 2000; 25(2): 95–100.
  12. Penetar DM, et.al., Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers, Journal of Alternative and Complementary Medicine 2006; 12(6): 543–548.

Dose: 6-24g

Ju Hua – Chrysanthemum Flower

Nature: acrid, sweet, bitter, slightly cold

Enters: Liver, Lung

Actions: Moves liver Qi, subdues liver Yang rising, clears liver heat; disperses wind and clears heat from the liver and Lungs; eliminates toxicity; promotes vision; can protect the Lungs; nourishes water of the kidneys; said to promote longevity.

Indications:
• Wind-heat: fever, dizziness, headache.
• Liver wind-heat or flaring of liver fire: red, swollen, painful eyes.
• Liver Yang rising leading to stirring of liver wind: headache, dizziness, deafness,
hypertension.
• Liver and kidney Yin deficiency: seeing spots in front of the eyes, blurry vision, dizziness.
• Cook a short time (retain the acridness) to disperse wind-heat, cook longer (boil off the acridness, retain the bitterness) to subdue liver Yang.
• This herb is said to have the energy of autumn – it can protect the Lungs.
• Stronger than Sang ye at clearing liver fire, but weaker at dispersing wind-heat.
• Compared to Mu zei, with regard to the vision: Ju hua nourishes the eyes, but does not remove superficial visual obstruction (as Mu zei does).
Bai ju hua: white variety: stronger than the yellow variety at subduing liver Yang, freeing/nourishing the liver and clearing the eyes; often used for poor vision due to liver/kidney Yin deficiency; better for hypertension.
Huang ju hua: yellow variety: stronger than the white variety at clearing heat and dispersing wind-heat.
HF: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas.
SD: May help antidote lead poisoning.
Yoga: Sevanti – “Service,” gives the energy of devotion, surrender, and service to the Divine.
• Bitter, sweet/cooling/pungent; P, K-; V+ (in excess).
• Affects digestive, respiratory, nervous systems.
• Diaphoretic, antipyretic, alterative, antispasmodic.
• For headache, sore throat, nose bleeds, eye infections, boils, dysmenorrhea, liver diseases.
• Cools and regulates the Pitta that governs vision.
• Calms Pitta emotions: anger, irritability.
• Promotes lactation and menstruation.
• Caution with high Vata.
• Aids in the surrender of the egoistic will (a function of deranged Pitta) to the Divine.
MLT: Drink cool in the summer to protect Yin and blood.
• Good for digestive upset, hypertension, headache, summer-heat.
DY: Light and upbearing in nature.
• With Gou qi zi to effectively nourish and supplement the liver and kidneys, clear heat, calm the liver, and brighten the eyes. For indications such as blurred vision, diminished visual acuity, “moving black spots in front of the eyes,” fire sparks in the eyes, photophobia, dry eyes with distention and headache, and pain in the lower back and knees due to liver-kidney deficiency. For these indications, the combination is present in Qi Ju Di Huang Wan. Bai ju hua should be used. Ju hua carries the action of Gou qi zi toward the eyes.
• For eye problems, hypertension, or headaches with a feeling of distention, use 20-30g of Ju hua daily.
• (Bai) Ju hua yields very good results in hypertensive disorders, especially when accompanied by vertigo and headaches mainly due to liver Yang rising. It is often combined with Shan zha (15-20g), is cases of hypercholesterolemia.
Hsu: Hypotensive: suppresses the motor center controlling blood vessels and is vasodilatory.

Dose: 4.5-15g

Man Jing Zi – Vitex fruit

Nature: acrid, bitter, neutral

Enters: Bladder, Liver, Stomach

Actions: Disperses wind-heat; eases eyes and headaches; drains dampness; expels wind; traditionally said to promote beard growth in men.

Indications:
• Wind-heat: dizziness, headaches, migraines.
• Upper attack of wind-heat: blurry vision, red, painful, swollen eyes, lots of tears, spots in front of the eyes.
• Wind-dampness in the limbs/joints: stiffness, numbness, cramping, heaviness.
Hong Jin: Particularly good for the pain of wind-damp Bi.
Wei Li: Good for Shaoyang headaches behind the eyes.
Heiko Lade: From Li Shi Zhen’s Ben Cao Gang Mu [provided by John Black]:
Main Uses: Treatment of heat and cold between tendons and bones, damp Bi type cramps, brightens the eyes, and strengthens the teeth. Regulates the nine orifices and expels “bai chong” (the Chinese character indicates some kind of worm, bug, parasite, etc.). Prolonged use of this herb can prevent aging. Can treat headache caused by wind, ringing in the head, lacrimation; benefits the Qi. It can enliven and brighten the spirit, and has been said to be able to expel pathogenic Qi and help the hair to grow. It has also been said to be able to free up the joints, treat epilepsy, red eyes, and Taiyang type headache. It can treat heaviness in the head (and implies some state bordering on unconsciousness), disperse pathogenic wind, cool menstrual blood, treat aching eyes, soothe liver wind, treat headache caused by wind, darken head hair and treats mastitis in the early stages. Through its effect on enhancing beard growth and the hormonal effects attributed to its Western cousin, I believe this herb is a tonic to the Chong Mai.
A final note though. It is contraindicated for those with deficient stomach Qi. The effect of Man Jing Zi in my experience is similar to He Shou Wu in that it can cause bloating, loose stools, sometimes explosive bowels with those people with a digestive insufficiency. Bai Zhu seems to counteract this well.

Dose: 6-12g
On the Western species: Vitex agnus-castus – Chaste berry:
It has not been clearly established as to whether the Chinese species shares all properties of the Western species.
New Age Herbalist: For menstrual and menopausal disorders; probably an anaphrodisiac – lowers sex drive.
• Increases production of luteinizing hormone and prolactin; stimulates the flow of milk.
• Regulates menses when they are too frequent or too heavy.
• Seems to stimulate progesterone synthesis and regulate estrogen: for PMS and menopause.
• For fibroids and inflammation of the womb lining.
• Re-establishes normal ovulation and menses after discontinuance of the pill.
Kenner & Requena: Sympatholytic, antispasmodic, estrogen antagonist, FSH inhibitor, luteotropic, galactagogue.
• Sweet-cooling; fire excess, wood excess.
Fire: nervousness, genital excitation, dysmenorrhea, acne; anti-FSH; sympatholytic; stops excess bleeding, corrects a shortened menstrual cycle.
Wood: neurotonia, globus hystericus, liver depression, palpitations, tachycardia, dysmenorrhea, uterine fibroids, hemorrhage, acne, genital excitation, mastosis and breast tenderness, male impotence from excessive sexual excitation, epigastric tightness, PMS, amenorrhea, menorrhagia, irregular menstrual cycle, menstrual and pre-menstrual edema, normalizes milk production (either too much or too little), cystic breasts-normalizes ratio of estrogen to progesterone; anti-FSH, sympatholytic.
Rudolf  Weiss: Increases LH production and inhibits release of FSH, leading to a shift in the ratio of estrogens to gestagens, in favor of gestagens, and hence a corpus luteum hormone effect.
• Menstrual disorders due to corpus luteum insufficiency (hyper or polymenorrhea and PMS based on hyperfolliculinism).
• Also for acne; pre-menstrual oral herpes; pre-menstrual water retention.
• Lactagogue (slow effect).

Mu Zei – Equisetum hiemale – Horsetail – Scouring Rush – “Wood Thief”

Nature: sweet, bitter, neutral

Enters: Lung, Liver

Actions: Mildly disperses wind-heat; promotes vision, dispels nebulas; stops bleeding; clears heat.

Indications:

• Wind-heat affecting the eyes: red eyes, excessive tearing, pain, swelling, cloudiness, blurred vision, pterygium.
• Heat in the blood: bleeding hemorrhoids, hemafecia (usually used as an auxiliary herb).
• Pulmonary disease: silicosis (improves symptoms).
• Also used externally as a powder.
• Compared to Ju hua, with regard to the vision, Mu zei is best for removing membranes from the conjunctiva (which Ju hua cannot do).
• Doctrine of signatures: the herb is a hollow tube – useful for clearing the tubes of the body – urinary tract, bile duct, air passages, vessels (not widely in this sense in TCM).
SD: May help antidote lead poisoning.
Yoga: Bitter, sweet/cooling/pungent; P, K-; V+
• Affects urinary, respiratory systems.
• Diuretic, lithotriptic, diaphoretic, alterative, hemostatic.
• Strong stone-removing action for the kidneys, bladder, gallbladder.
• Somewhat irritant, should not be taken for a long duration.
• Promotes healing of bones.
• Similar to Niu bang zi: as a paste/wash for inflammation.
• Clears Pitta and fiery emotions from the nerves and mind.
• For edema, nephritis, burning urethra, kidney stones, gall stones, stomach ulcers, broken bones, menorrhagia, venereal disease.
• Caution with patients with high Vata, constipation, dry skin; good for high Pitta.
NAH: Major source of silica – for lungs damaged by tuberculosis.
• Contains many minerals – good for anemia, debility, broken nails, lifeless hair, white spots on nails.
• Silicon encourages calcium absorption and helps guard against fatty deposits in the arteries.
• Astringent action stops bleeding, good for stomach ulcers.
• Mild diuretic, but its astringency makes it useful for children’s bed wetting.
• Also for inflamed/enlarged prostate, cystitis, urinary stones.
K&R: Remineralizing agent.
• Water deficiency, wood excess, water excess, metal deficiency, earth deficiency.
Water: edema, oliguria, ascites, glomerulonephritis, cystitis, nephrotic syndromes, osteoporosis, demineralization, pathological calcification, Paget’s disease, amenorrhea, diabetes.
Wood: hemorrhage, metrorraghia, epistaxis, hematuria, spasmophilia, tetany
Metal: immune deficiency, scrofula.
Earth: diabetes, chronic rheumatism, conjunctivitis, eyelid swelling.
MW: 35+% silica: its uses include almost the entire portrait of homeopathic Silicea: loss of nerve, nervousness to the point of nail-biting, hair-pulling, picking at the body or objects, slightly chilly constitution, problems with the hard sheaths and tissues of the body (strengthens tissue), thin, split hair, weak nails, lack of “grit” to the personality, no confidence to plunge into life, allergic to all sorts of things, chronic cystitis
• For all bleeding, ulcers.
• Brings matters to the surface, releases corrupted material.
• Doctrine of signatures: [see above on tubes] plus stem’s striking joints – for joints.
MLT: Cider vinegar extract of Mu zei: use topically for all fungus.
TS: Cleansing agent for the stomach.
• Reduces the suffering from gravel. For all bladder and kidney difficulties, especially stones in the bladder
• Painful urination.
• Hemorrhaging, hematemesis, epistaxis.
• As a compress for foul-smelling sores with pus.
Hsu: Appetite stimulant; diuretic; screening test shows it is effective against stomach, tongue, and liver cancers.

Dose: 3-9g

Niu Bang Zi – Arctium seed – Burdock seed

Nature: acrid, bitter, cool

Enters: Lung, Stomach

Actions: Disperses wind-heat; eliminates toxicity; expresses skin eruptions; eases the throat; relieves swelling; moistens the intestines for wind-heat constipation.

• Wind-heat: cough with difficult-to-expectorate sputum, swollen, red, and painful throat, fever.
• Wind-heat: slow skin eruption in early-stage measles or other incomplete skin rash.
• Heat and toxicity: red swellings, carbuncles, erythemas, mumps, acute febrile maculopapular rashes.
• Wind-heat: constipation.
• Good for constipation with sore, swollen throat.
• Prostatitis
• Weaker than Bo he at dispersing wind-heat and inducing sweating, but much stronger than Bo he at clearing heat and toxicity.
• Stronger at clearing heat than dispersing wind-heat, but much weaker at clearing heat and toxicity than the herbs in that category.
MLT: Should be crushed.
• Good for skin disease, cancer.
JC: Diuretic; alterative; tonic; nervine; diaphoretic.
• For edema, inflamed kidneys and bladder; scalding urine; mucus discharge from the bladder; difficult skin problems; eczema; boils; carbuncles; psoriasis.
• Topical: powder for abrasions, burns, wounds, ulcerations.
• Apply infusion topically to swollen glands and joints.
Yoga: (seeds and root) Bitter, pungent, astringent/cooling/pungent
• P, K-; V+ (in excess)
• Affects respiratory, urinary, circulatory, lymphatic systems.
• Alterative, diaphoretic, diuretic, antipyretic.
• Tonic and rejuvenative for Pitta.
• Same indications as above sources plus: lymphatic clogging, nephritis, edema, kidney inflammation, hypertension, cough.
K&R: Specific for all kidney afflictions; parotitis with constipation; eczema; cough; suppurative inflammation.
• Contracts the uterus.
IBIS: Alterative, demulcent, diaphoretic, diuretic, tonic.
• [Western] dosage: root tincture: 2 – 8 mL; seed tincture: 0.5 – 2 mL.
• Therapy: aphthous and catarrhal ulcerations of stomach membranes; irritable coughs; psoriasis; chronic cutaneous eruptions; chronic glandular enlargements; syphilitic, scrofulous, and gouty conditions (Ellingwood, p. 378); skin conditions, especially with dry and scaly skin; eczema; acne; boils; styes; carbuncles; arthritis; rheumatism (Anderson Geller)
• Handling fresh leaves may cause contact dermatitis (Duke; Muenscher)

Dose: 3-9g

Sang Ye – White Mulberry leaf – Morus alba

Nature: acrid, sweet, bitter, cold

Enters: Lung, Liver

Actions: Disperses wind and clears heat from the Lungs; clears heat from the liver to promote vision; cools the blood, stops bleeding (charred).

Indications:
• Wind-heat: cough, headache, fever, swollen and painful throat.
• Lung dryness: cough and dry mouth.
• Lung heat: thick and yellow sputum.
• Lung yin deficiency: night sweats, feeling hot at night.
• Liver channel heat (full or deficient) or liver wind-heat: red, dry, painful eyes, excessive tearing, spots in front of the eyes (for liver heat, empowers metal to control wood).
• Heat in the blood: mild cases of hematemesis.
• May lower blood sugar.
• Stronger than Ju hua to disperse wind-heat, but weaker to clear liver fire.
• Fry with honey (honey:herb::1:10) to moisten the Lungs for invasion of dryness and treat coughing.
• Doctrine of signatures: (supposedly) looks like a lung.
• Grows in the spring and contains the energy of spring.
• Can be used as an external wash for eye problems.
• This is the food of the silkworm.

Dose: 4.5-15g

A Non-Traditional Category: Herbs That Generate Body Fluids and Moisten the Lungs

Ge Gen / Pueraria root
Sheng Di  Huang / Raw Rehmannia root
Lu Gen / Phragmites rhizome
Tian Hua Fen / Trichosanthes root
Ren Shen / Ginseng root
Dang Shen / Codonopsis root
Tai Zi Shen / Pseudostellaria root
Wu Wei Zi / Schizandra fruit
Wu Mei / Mume fruit
Sang Ye (Zhi) / Honey-fried Morus leaf Gua Lou / Trichosanthes fruit
Chuan Bei Mu / Fritillaria bulb
Bai Bu / Stemona root
Kuan Dong Hua / Tussilago flower
Zhi Mu / Anemarrhena root
Gan Cao / Licorice root
Yi Tang / Maltose
Feng Mi / Honey
E Jiao / Donkey hide Gelatin
Xing Ren / Apricot kerne

A Non-Traditional Category: Herbs That Nourish or Support Jing

Bu Gu Zhi / Psoralea seed
Che Qian Zi / Plantago seed
Ge Jie / Gecko
Gou Qi Zi / Lycium fruit
He Shou Wu / Polygonum multiflorum root
Hei Zhi Ma / Black Sesame seed
Huang Jing / Polygonatum sibiricum root
Ji Nei Jin / Chicken Gizzard lining
Jiu Zi (Jiu Cai Zi) / Allium seed
Lu Rong & Lu Jiao / Deer Antler Lu Jiao Jiao / Deer Antler Gelatin
Rou Cong Rong / Cistanche stem
Sha Yuan Ji Li / Astragalus seed
Shan Zhu Yu / Cornus fruit
Shu Di Huang / Prepared Rehmannia root
Suo Yang / Cynomorium stem
Tu Si Zi / Cuscuta seed
Yi Zhi Ren / Alpinia oxyphylla seed
Yuan Zhi / Polygala root
Zi He Che / Placenta

This list doesn’t include herbs that merely astringe/secure Jing.

 

A Non-Traditional Category That I Feel Is Of Value – Fetus-Protecting Herbs

Ai Ye / Artemisia leaf
Bai Zhu / White Atractylodes root
Du Zhong / Eucommia bark
E Jiao / Donkey Hide Gelatin
Huang Qin / Scutellaria baicalensis root
Huang Qi / Astragalus root
Lian Fang / Lotus receptacle
Sang Ji Sheng / Mistletoe (from Mulberry tree)
Sha Ren / Amomum villosum/xanthioides seed
Tu Si Zi / Cuscuta seed
Xu Duan / Dipsacus root
Zhu Ma Gen  / Boehmeria root
Zi Su Ye & Geng / Perilla leaf and stem

A Non-Traditional Category That I Feel Is Of Value: Herbs That Free Constrained Liver Qi

Bai Ji Li / Tribulus seed
Bai Shao Yao / White Peony root
Bo He / Chinese Mint
Chai Hu / Bupleurum root
Chuan Lian Zi / Melia fruit
Fang Feng / Siler root (? According to Guohui Liu)
Fu Shou (Fo Shou) / Finger Citron fruit
He Huan Hua / Albizzia flower
Ju Hua / Chrysanthemum flower
Mei Gui Hua / Red Rose bud Mai Ya / Barley sprout
Qing Pi / Immature Tangerine peel
Wu Zhu Yu / Evodia fruit
Xian He Cao / Agrimony herb
Xiang Fu / Cyperus rhizome
Xuan Fu Hua / Inula flower
Yin Chen Hao / Artemisia capillaris herb
Yu Jin / Curcuma tuber
Ze Lan / Lycopus herb
Zhi Ke / Mature Bitter Orange

Shi Jun Zi – Rangoon Creeper fruit with seeds – Quisqualis – “Envoy Seeds”

Nature: sweet, warm

Enters: Stomach, Spleen

Actions: Kills parasites (particularly roundworms); eliminates food retention; strengthens the spleen; dissolves accumulations.

Indications:

• Roundworms or malnutrition in children due to improper diet, weak constitution: abdominal distention, poor appetite. If roundworms are severe, this herb can be combined with Bing lang.
• Common side effects: nausea, vomiting, belching
• To reduce the herb’s toxicity, dry fry it until it is aromatic.
• Traditionally, this herb is not to be taken with hot tea (may lead to diarrhea and belching).
• Sources differ on dosage guidelines:
Liu: One piece per day for no more than 20 days (may discontinue for a week and then resume administration).
Bensky and Gamble: 1 piece per year of age, per day, not to exceed 20 pieces per day.
Li: No more than 12 pieces per day.

Dose: 4.5-12g

Zhang Nao – Camphor

Nature: acrid, hot, toxic

Enters: Heart, Spleen

Topical Actions: Expels wind and dampness; kills parasites; promotes blood circulation, alleviates pain.

Topical Indications:
• Scabies, ringworm, itching sores
• Blood stasis: injuries, pain and swelling.
• Used topically as a powder or paste.
• Warming, irritative, and antiseptic effect on the skin. Mildly locally anaesthetic.
Hsu: Irritant effect – promotes blood circulation, increases mucosa secretion.

Internal Actions: Opens the orifices of the heart; expels turbidity.

Internal Indications:
• Delirium, sudden unconsciousness due to hot disorders.
• When taken orally, it irritates the gastric mucosa. In small doses, this causes a comfortably warm feeling. In large doses it causes nausea and vomiting.
Zhang nao stimulates the central nervous system, particularly the higher centers. Normal doses have no effect on respiration, but large doses can stimulate respiration.
• Oral doses of 0.5-1g can cause dizziness, headache, a feeling of warmth and restlessness. Over 2g leads to transient tranquilization followed by stimulation of the cerebral cortex with tonic-clonic spasms. Respiratory arrest can occur. 7-15g is fatal.
Yoga: Karpura: pungent, bitter/slightly heating/pungent; Sattvic.
• K, V-; P+(in excess)
• Expectorant, decongestant, stimulant, antispasmodic, bronchodilator, nervine, analgesic, antiseptic.
• Bronchitis, asthma, pertussis, pulmonary congestion, hysteria, epilepsy, delirium, insomnia, dysmenorrhea, gout, rheumatism, nasal congestion, sinus headache, eye problems, tooth decay.
• This herb is poisonous in excess: aggravates Pitta and Vata
• Increases prana, opens the senses, clears the mind.
• Applied to the eyes (in small amounts): initially burning, but promotes tears and cools and clears the eyes.
• Nasally: for congestion, headache, and to awaken perception.
• Burn as incense during devotional worship to purify the atmosphere and promote meditation.
• Use ONLY genuine, raw camphor internally.
Hsu: Stimulates the CNS; antifungal.

SD: Camphor oil is obtained from a tree (Cinnamomum camphora), and like cardamom, the essential oil of the tree contains a large number of terpenoids (mostly, the same ones as in cardamon, but in different proportions). Camphor was collected at least as early as the 9th Century. In 1676, the trees were brought to Europe for cultivation. In the following century, it was also introduced to several other countries, including the U.S. Prior to World War II, the world use of camphor was about 5,000 tons per year; 80% of this came from Taiwan (the Taiwan camphor tree yields 44% camphor from its leaves, a particularly high level). During the U.S. Civil War, the demand for camphor (used primarily as a medicinal) was so high that the U.S. contracted for the entire Taiwan supply. It was even proposed that an effort be made to purchase Taiwan (then called Formosa) in order to monopolize the camphor trade. It is perhaps for this reason that Japan acquired Formosa in 1895.
Camphor oil was a popular medicinal in the U.S. until about twenty years ago when several instances occurred in which children were fed camphor oil by parents who failed to distinguish it from castor oil. The pure camphor oil is toxic in the doses for which castor oil is used. Also, the U.S. Food and Drug Administration worried that topically applied camphor oil would penetrate the skin in sufficient amounts that it could cause trouble for persons with cardiac disorders who were taking various medications. As a result, it is no longer possible to purchase camphor oil for household use in the U.S.
Like borneol, camphor has been used as an antiseptic, antispasmodic, carminative, cardiac stimulant, respiratory aid, and anthelmintic. It is often used in treating congestive problems such as bronchitis and emphysema. Camphor is also used in preparation of foods, being an ingredient of vanilla and peppermint flavors, and incorporated into formulations of soft drinks, baked goods, and condiments. In modern Chinese medicine, camphor is most often reserved for external application, while borneol is used both internally and externally. Synthetic camphor, often made from by chemically modifying pine tree resins (turpentine), is now widely used as a substitute for the natural product.
Camphor and the chemically related compound camphene are found in: cardamom, saussurea, ginger, magnolia, curcuma, cinnamon, nutmeg, and cyperus.

Internal Dose: 0.1-0.2g in pills or dissolved in wine

Zong Lu Tan – Charred Stiple Palm Fiber – Trachycarpus – “Palm Stipule”

Nature: bitter, astringent, neutral

Enters: Liver, Large Intestine, Lung, Spleen

Actions: Stops bleeding by powerfully astringing.

Indications:
• Hemoptysis, hemafecia, epistaxis, uterine bleeding without blood stasis.
• Can cause blood stasis – use with a blood mover if there is a risk of stasis.
• Charring increases the herb’s astringent and stabilizing properties.
• The uncharred herb (rarely used) is called Zong lu pi.

Dose: 9-15g (1-1.5g as powder)

Ying Su Ke – Opium poppy seed capsule – Papaver somniferum

Nature: sour, astringent, slightly toxic, neutral

Enters: Lung, Large Intestine, Kidney

Actions: Astringes Lung Qi; astringes the large intestine; relieves pain; stabilizes the lower Jiao.

Indications:
• Lung Qi or Yin deficiency: chronic cough.
• Spleen Yin, Qi, or Yang deficiency: chronic diarrhea or dysentery.
• Pain: chest, abdomen, tendons, bones, epigastrium (temporary use).
• Instability of the lower Jiao: polyuria, spermatorrhea, vaginal discharge.
• Use raw or vinegar-fried to stop diarrhea and pain.
• Use honey-fried to benefit the Lungs and stop coughing.
• This herb cannot be legally prescribed in the United States.

Dose: 1.5-6g

Of the many narcotic constituents of the opium poppy, perhaps the best known are morphine and codeine. Morphine is a strong analgesic, hypnotic, strong and selective respiratory depressant (may cause respiratory arrest), antitussive, causes peripheral vasodilation and histamine release, very low doses cause constipation by various means. Morphine is the analgesic standard against which all other analgesics are judged. In all respects, codeine is much weaker. It has about one-fourth the analgesic strength of morphine and is a weaker anti-tussive, but it is more commonly used because it has fewer side effects. All narcotic poppy derivatives have significant abuse potential.

Yu Zhu – Polygonatum odoratum or P. officinale rhizome – Solomon’s Seal – “Jade Bamboo”

Nature: sweet, neutral

Enters: Lung, Stomach

Actions: Nourishes Yin; moistens dryness; produces body fluids for the stomach; extinguishes wind; softens and moistens the sinews.

Indications:
• Lung and stomach Yin deficiency: dry cough, dry mouth, thirst, irritability, steaming bone disorder, wasting and thirsting with intense hunger and constipation.
• Wind-heat attack with a Yin deficient constitution: fever, sore throat, cough, thirst.
• Insufficient fluids leading to wind: pain and spasm of the sinews.
• Yin deficiency plus internal wind: dizziness.
• Not cloying, will not trap EPIs in the body.
• Use raw to clear heat.
• Steam until it turns black (more like Huang jing) to nourish Yin and tonify the middle Qi.
• Useful in treatment of second- or third-degree heart failure.
• Weaker than Shi hu at nourishing stomach Yin. Yu zhu is a better choice when there is stomach Yin xu with an EPI.
• Weaker than Tian men dong at clearing heat, but does not have the disadvantage of Tian men dong’s severely cloying nature which can easily produce stagnation.
Hsu: Laxative, diuretic, lowers blood sugar, may have adrenocortical hormone-like effects.
Yoga: Meda, Mahmeda: VPK=; K or ama+ (in excess)
• Nutritive tonic, rejuvenative, aphrodisiac, demulcent, expectorant, hemostatic.
• Tonic to Vata and Pitta and to semen and reproductive tissue.
• For debility, infertility, impotence, chronic bleeding, diabetes, consumption, dry cough, dehydration, malnutrition, burning sensation, broken bones, inflamed mucus membranes.
MW: Muscular and skeletal problems: loosens or tightens ligaments as necessary, keeps adjustments in place, corrects tension, feeds and lubricates ligaments, tendons, muscles, and attachments, joins and seals broken bones, decalcifies unhealthy deposits and spurs, strengthens and harmonizes.
• Also for bruises, burns, sores.
• Wolf medicine: wolves eat this for indigestion.
• Helps build up intestinal bacteria; soothes and coats mucosa.
• Gentle regulator of heart muscle, mild cardiac tonic.
• Its berries are poisonous.
PCBDP: Astringent, demulcent, tonic.

Dose: 9-15g

Zi He Che – Human Placenta – “Purple River Vehicle”

Nature: sweet, salty, warm

Enters: Lung, Liver, Kidney

Actions: Nourishes blood; tonifies Qi; tonifies the kidneys and liver, nourishes Jing; promotes lactation.

Indications:
• Kidney Qi and Jing deficiency: infertility, impotence, seminal emission, soreness in the lumber region, dizziness, tinnitus, lightheadedness.
• Qi and blood deficiency (especially postpartum): thin muscles, pallor, scanty lactation.
• Lung and kidney Qi deficiency: asthma/wheezing (especially useful between acute attacks); consumption with night sweats, emaciation, debility, chronic wheezing and cough.
• Unremitting seizure disorders.
• Cancer with severe anemia: use fresh placenta with Huang qi and Dang gui.
• May enhance immune function: HIV, TB.
• Used for bleeding from factor XIII deficiency.
• Enhances wound healing.
• May be of benefit in COPD.
• Cooler and weaker at nourishing Jing than Lu rong, but stronger at nourishing blood.
• Placenta from China is usually from animals. Also is usually bleached. Dried placenta is normally dark red, since it’s full of blood. If collected from women, should be sure any potential blood-borne pathogens are killed.
Hsu: Anti-infectious: increases the body’s immune resistance, anti-allergic actions, contains a substance which acts as an antibody against measles, influenza.
• Inhibits precipitation of fat in the liver.
• Stimulates the testes, stimulates production of chorionic hormones, stimulates production of female sex hormones, including for pregnancy.

Dose: 1.5-4.5g

Yi Tang – Maltose – Grain Malt Extract

Nature: sweet, warm

Enters: Spleen, Stomach, Lung

Actions: Tonifies spleen Qi; relaxes the muscles to relieve pain; moistens the Lungs; stops coughing.

Indications:
• Spleen Qi deficiency (including by overexertion): poor appetite, fatigue, shortness of breath.
• Lung Yin deficiency: dry, nonproductive cough, difficult or slow, labored breathing, weak voice.
• Spleen cold and Yang deficiency: abdominal pain (relieved by warmth and pressure), excessive salivation, pale tongue, white coating, deep, slow pulse.
• Not usually a chief herb for Qi tonification. Used to make a formula taste better.
• Weaker than Gan cao at relaxing the muscles to relieve pain.
• Compared to Dang shen, while Dang shen can be used for a deficiency-induced cough with profuse sputum, Yi tang is indicated more for a non-productive deficiency-induced cough.
• Contraindicated with vomiting, abdominal distention due to damp-heat, phlegm-heat cough, infant malnutrition.
• Preparation: barley malt is cooked with rice flour (glutinous or non-glutinous) or wheat flour.
• Rich in minerals.
• Dissolve in a strained decoction at the very end of cooking.
CDT: Made from grains such as glutinous or non-glutinous rice, wheat, millet, barley, maize, through fermentation.
• Performs functions listed above plus detoxifies.
• Spleen and stomach deficiency with loss of appetite, fatigue, abdominal pain: decoct with cinnamon twig, common peony, ginger, dates, licorice.
• Lung deficiency with dry cough, sore throat, shortness of breath: take Yi tang alone or steamed with turnip juice until it melts.
• Poisoning or unwanted reaction caused by overdose of Fu zi or Wu tou: take Yi tang immediately.
• Taken chewed, sucked, or decocted.

Dose: 30-60g

Shu Di Huang – Rehmannia root (Wine-cooked) – “Cooked Earth Yellow”

Nature: sweet, slightly warm

Enters: Liver, Heart, Kidney

Actions: Nourishes blood and Yin; supports the Jing and marrow.

Indications:
• Blood deficiency: sallow face, dizziness, insomnia, palpitations, irregular menstruation, uterine bleeding, postpartum bleeding.
• Kidney Yin deficiency: tidal fever, night sweats, seminal emission, steaming bone disorder, wasting and thirsting disorder (may correspond with diabetes), low back and joint pain, vertigo.
• Jing and blood/Yin deficiency: weak lumbar region, knees and lower extremities, dizziness, poor hearing and vision, early greying of hair.
• Very greasy – can cause nausea and damage the digestion (often combined with or toasted with Chen pi and Sha ren).
Shu di’s function to nourish the Jing is not as strong as Lu rong.
• May lower blood pressure and serum cholesterol.
• Bensky/Gamble: compared to He shou wu, Shu di is thought to focus more on the kidneys, while He shou wu focuses more on the liver. [Though preparing He shou wu with black soy beans enhances its action on the kidneys.]
PFGC: Treats asthma due to Yin deficiency and failure of the kidneys to absorb Qi.
• Taxation cough.
• Kidney deficiency leading to inhibition of the kidneys’ filtering process, causing decreased urination and eventually edema.
• Treats injury to the Yin layer of all organ networks.
Hsu: Cardiotonic; dilates renal blood vessels, diuretic; hypoglycemiant.
Yoga: P, V-; K and Ama +
• Tonic, rejuvenative, aphrodisiac, demulcent, laxative, emmenagogue.
• For weak kidneys, lumbar pain, sexual debility, irregular menses, cirrhosis, anemia, hair loss, diabetes, senility.
DY: With Dang gui to nourish blood, enrich Yin, supplement the liver and kidneys, downbear the Lung Qi and promote Qi intake by the kidneys, stop cough, and calm asthma. See Dang gui for specific indications and notes.
Shu di and Dang gui are probably the two most effective medicinal substances for treating constipation due to blood deficiency.
Shu di is incompatible with animal blood, onions, chives, turnips, radishes, and garlic.

Dose: 9-30g

Zi Shi Ying – Fluorite (Calcium Fluorite) – (Amethyst also used) – “Purple Stone Radiance”

Nature: sweet, warm

Enters: Heart, Liver

Actions: Sedates the heart; settles tremors and palpitations; warms the Lungs; directs Qi downward; warms the womb.

Indications:
• Heart blood deficiency or liver Yang rising: disorientation, trauma, insomnia, anxiety, convulsions.
• Lung deficiency cold: cough, wheezing, copious sputum.
• Deficiency cold of the womb: excessive menstruation, uterine bleeding, infertility.
• Best herb in the category for palpitations and irritability due to Yang rising and excessive heart fire due to blood deficiency.
• Cook 20-30 minutes longer than other herbs.

Dose: 6-15g

Su He Xiang – Resin of Rose Maloes – Liquidambar sap – Styrax – “Revive and Join Fragrance”

Nature: sweet, acrid, warm

Enters: Heart, Spleen

Actions: Opens the orifices and penetrates thru turbidity; opens up areas of constraint and clears away filth.

Indications:
• Closed disorder, phlegm blockage, epidemic toxic disease. Especially indicated for cold disorders.
• Stifling sensation, cold, fullness, and pain in chest and abdomen.
• Expectorant by irritating the respiratory mucosa.
• Compared to the other herbs in this category, Su he xiang is particularly useful for wind-stroke with collapse due to phlegm.
• When taken internally this herb is always administered in powder or pill form.
• Topical: with olive oil for scabies, also has some effect on eczema.
• Misleadingly called Styrax, this herb is actually the resin of Liquidambar orientalis (Rose Maloes) – see An Xi Xiang.
• Difficult to procure in the U.S.
PCBDP: Antiseptic, expectorant, stimulant.
• Inhale for cough/cold.
• Topical for wound/ulcer.
Hsu: Antibacterial, anti-inflammatory – promotes healing of ulcers.

Dose: 0.3-1g

Zhen Zhu Mu – Mother of Pearl

Nature: salty, cold

Enters: Liver, Heart

Actions: Subdues the liver and suppresses any type of liver Yang rising; clears liver heat; promotes vision; anchors the Shen.

Indications:
• Liver Yang rising and liver Yin deficiency: headache, dizziness, vertigo, tinnitus, restlessness, insomnia, seizures.
• Liver Yin deficiency: blurry vision.
• Liver heat: red eyes, photophobia.
• Topical: promotes healing of canker sores.
• Commonly used as a cheap substitute for Zhen zhu, though it is much less effective.
• Must be cooked longer than other herbs.
• Difficult to digest (like all shells and minerals).
• Bensky/Gamble classifies with herbs that anchor the Shen.
• As a topical facial exfolliant. One source claims machine grinding produces a powder too fine to exfolliate effectively. Hand grinding may be preferable.
MLT: Promotes healing, generates flesh.
• Topical for acne/blemishes.

Dose: 15-30g

Zi Ran Tong – Iron Pyrite (An Iron Sulfide)

Nature: acrid, neutral

Enters: Liver, Kidney

Actions: Dispels blood stasis, relieves pain; promotes regeneration of bones and sinews.

Indications:
• Blood and Qi stasis caused by injury: swelling, pain, and especially fractures.
• Has been used successfully for endemic goiter.
• Decoct for at least 30 minutes or take directly as powder.
• Major known constituents include: ferrous disulfide, copper, nickel, arsenic. Due to arsenic content, probably toxic.

Dose: 3-15g (0.3-0.6g directly as powder)

Zhi Ke – Zhi Qiao – Mature Bitter Orange

Nature: bitter, cool

Enters: Spleen, Stomach (according to Wei Li, also enters San Jiao)

Actions: Moves/regulates Qi; directs Qi downward; eliminates food retention (particularly in the large intestine), breaks up stagnation and accumulation; resolves phlegm; relieves distention; unblocks the bowels. In all respects, milder than Zhi shi.

Indications:
• Milder, perhaps more often used than Zhi shi, especially for weak or deficient patients – less energy than the unripe fruit and less potential to damage the Qi.
• Frequently used to move Qi and reduce distention and pressure.
• Stifling sensation in the chest with belching.
• Particularly useful for stagnation in the flanks.
Zhi shi is more appropriate than Zhi ke when there is constipation.
Li: Zhi ke is more liver-oriented than Zhi shi, which is more spleen-oriented.
[Bensky/Gamble corroborates this idea, stating that Zhi shi is used for stagnant Qi of the spleen and stomach while Zhi ke is used for constrained liver Qi with symptoms of stagnant Qi.]
Hsu: Stomachic; contracts the uterus; increases blood pressure.
DY: This is one of six medicinals which have been traditionally aged for the purpose of reducing secondary effects and reinforcing their therapeutic actions. Generally, the longer it is kept, the more efficient.
• With Jie geng to effectively regulate upbearing and downbearing, regulate the upper and middle burners, diffuse the Lung Qi, and loosen the chest and diaphragm. For indications such as:
– 1. Chest and diaphragm oppression or distention or chest Bi due to accumulation of phlegm and Qi stagnation. (Jie Geng Zhi Ke Tang)
– 2. Epigastric distention, stomach rumbling, and difficult defecation due to disturbance of ascending and descending. Note: Zhi ke and Jie geng do not moisten the intestines, do not soften the stools, and do not precipitate the bowels. However, Zhi ke moves and descends the Qi in the large intestine in order to improve evacuation of the stools, while Jie geng disperses and descends Lung Qi. When the Lung Qi correctly descends, the large intestine Qi does the same. Therefore, although Zhi ke and Jie geng do not have a direct action on peristalsis, they can treat constipation due to Lung-large intestine Qi stagnation. Hence, this pair may be used to advantageously reinforce any formula that specifically treats constipation.

K&R: (maturity not stated) Sedative (CNS), antispasmodic, expectorant, eupeptic, sympatholytic.
• Bitter-cooling; fire excess, wood excess.
Fire: tachycardia, anguish, nervousness, anxiety, insomnia, epilepsy.
Wood: aerophagia, dyspepsia, digestive spasms, tachycardia of emotional origin, anxiety, insomnia.
• Good for cooling liver fire stemming from heart fire.

Dose: 3-9g

Zhi Shi – Immature Bitter Orange

Nature: bitter, acrid, slightly cold

Enters: Spleen, Stomach, Large Intestine

Actions: Strongly moves/regulates Qi; directs Qi downward; eliminates food retention (particularly in the large intestine), breaks up stagnation and accumulation; resolves phlegm; relieves distention; unblocks the bowels

• Accumulation and stagnation: epigastric or abdominal pain and distention or indigestion with focal distention or gas.
• Accumulation and stagnation, including due to food retention in the large intestine: distention in the abdomen, constipation or diarrhea with tenesmus.
• Phlegm obstruction with Qi stagnation: distention and fullness in the chest and epigastrium.
• Particularly useful for stagnation in the chest and upper back.
• Lifts prolapse of the stomach, uterus, or rectum. Used with Qi tonics for gastriectasis, gastroptosis, rectal prolapse, uterine prolaspe, etc.
• Raises blood pressure.
• Contains cirantin (inhibits activity of periovicular hyaluronidase) which may account for its reported contraceptive effect.
• Recent use in Western OTC weight loss products.
• The herb may have some use in treating cardiogenic shock.
Liu: For urinary stones, Zhi shi helps the urethra relax.
Hsu: Stimulates GI motor activities, increases digestion; contracts the uterus; purgative; raises blood pressure.
DY: With Bai zhu to supplement without producing stagnation and drain without damaging the correct Qi, to fortify the spleen, disperse food stagnation, and effectively eliminate accumulations and distention. For the following indications, except as otherwise indicated, the two herbs should be stir-fried:
– 1. Accumulation of food, distention and fullness of the abdomen and epigastrium, and difficult bowel movements due to spleen Qi deficiency and Qi stagnation. (Zhi Zhu Wan) When the patient’s main complaint is abdominal and epigastric distention due to Qi deficiency and spleen deficiency with or without dampness, the dosage for Bai zhu should be very high – as much as 100g per day. In this case Bai zhu is generally used alone.
– 2. Splenomegaly and hepatomegaly due to Qi deficiency and stagnation.
– 3. Ptosis of the organs (stomach, uterus, and anus) due to central Qi deficiency. For these indications, honey mix-fried Huang qi, stir-fried Chai hu, and honey mix-fried Sheng ma should be added.

K&R: (maturity not stated) Sedative (CNS), antispasmodic, expectorant, eupeptic, sympatholytic.
• Bitter-cooling; fire excess, wood excess.
Fire: tachycardia, anguish, nervousness, anxiety, insomnia, epilepsy.
Wood: aerophagia, dyspepsia, digestive spasms, tachycardia of emotional origin, anxiety, insomnia.
• Good for cooling liver fire stemming from heart fire.

Dose: 3-9g

 

Examine.com on synephrine:

A recommended dosage is 10-20mg, taken thrice a day.

Acute dosages of 50mg are also frequently used, although not thrice a day.

1. Sources and pharmacology

Synephrine is found from the Bitter orange plant, latin name Citrus aurantium. The plant contains a few active ingredients, namely para-synephrine(p-synephrine) and octopamine.[1][2] Although meta-synephrine and ortho-synephrine could exist in fruits, they have not been observed in C.aurantium.[3]

Typically, ‘synephrine’ in supplements refers to P-synephrine despite m-synephrine (also known as phenylephrine) having many of the same properties.[4]

2. Effects on fat metabolism

2.1. Mechanisms

P-synephrine is a beta-agonist compound similar to Ephedrine[5][6]. It can increase the metabolic rate via increasing lipolysis and basal metabolic rate.[1] These effects are independent of diet for the most part, and can exert a passive increase in basal metabolic rate to produce weight loss over an extended period of time.

Synephrine also has alpha-adrenergic antagonist capabilities. Affecting both the A1 and A2 receptors, albeit with a different potency.[7] In both the cases of alpha and beta agonism, the effects of both forms of synephrine are much less than that of noradrenaline.

2.2. Human studies

It has been implicated in increasing the thermic effect of food, but one study noted this effect only in women.[8]

3. Potential Synergism

P-synephrine (50mg) was shown to be highly synergistic with both the Bioflavonoids naringin and hesperidin, but not both, in regards to increases in basal metabolic rate.[9]

Like Ephedrine, P-synephrine also shows synergism with Caffeine and is more pronounced in naive caffeine users.[10]

 4. Safety profile

P-synephrine does not seem to be a causative agent in increasing blood pressure[11][12][8]

The Bitter Orange itself (the parent plant) has been linked to increased systolic and diastolic blood pressure.[13] Additionally, a common patented blend of P-synephrine known as Advantra-Z (which contains active bioflavonoids such as naringen and Hesperidin) has been linked to an increase in blood pressure.[11]

Overall, usage of P-synephrine appears to be quite safe and free of most adverse side effects.[14]

Xiao Hui Xiang – Fennel seed

Nature: acrid, warm

Enters: Liver, Kidney, Stomach, Spleen

Actions: Disperses cold, relieves pain; regulates Qi, harmonizes the stomach; frees the liver Qi, warms and moves the liver channel and lower Jiao, warms the kidneys.

Indications:
• Cold in the liver or kidneys: severe pain in the lower abdomen and testes, especially in cases of hernia. Useful for any kind of lower abdominal pain due to cold. In one study of 26 cases of incarcerated hernia, Xiao hui xiang was given orally and then patients were asked to lie supine with their knees bent. The hernia and symptoms were reduced in 22 cases, usually within a half hour. The longer the incarceration, the less effective the treatment.
• Stomach cold: vomiting, poor appetite, indigestion, distending pain in the epigastrium or abdomen. (Wu zhu yu and Ding xiang are superior.)
• Regulates intestinal peristalsis, reducing emptying time and increasing the passage of gas. It also relieves spasms of the intestines.
• Topical: powder the herb, heat it (under a TDP lamp, in a microwave, or by dry-frying it), put it in a tea bag, and place it over a hernia or an area with a sensation of cold or pain.
• Hydrocele of the tunica vaginalis: Xiao hui xiang was given (with salt and other ingredients) at bedtime with rice wine. 59 of 64 cases were cured at six weeks and 1 was improved.
K&R: Carminative, eupeptic, expectorant, antispasmodic, galactagogue, diuretic (azoturic), urinary antiseptic.
• Earth deficiency, water deficiency, metal deficiency.
Earth: digestive insufficiency, colic, pediatric abdominal pain.
Metal: intestinal colic, colitis, pediatric- expectorant for bronchitis, asthma.
Water: oliguria, renal calculi, amenorrhea, frigidity, impotence, urinary infection.
• Use with a laxative for constipation with poor intestinal tone.
• Sedative and carminative for excitable children with indigestion.
Yoga: Shatapushpa: sweet, pungent/slightly cooling/sweet; VPK=
• Carminative, stomachic, stimulant, diuretic, antispasmodic.
• Indigestion, low Agni, abdominal pain, cramps or gas, difficult or burning urination, children’s colic.
• Stops griping from purgatives.
• Helps promote menstruation and lactation.
• Good for all constitutions. Strengthens Agni without aggravating Pitta.
• The aroma acts on the mind, produces alertness.
Hsu: Expectorant, stomachic.

Dose: 3-9g

Shen Qu – Medicated Leaven (Usually composed of 6 herbs) – “Divine Fermented Mass”

Nature: acrid, sweet, warm

Enters: Stomach, Spleen

Actions: Promotes digestion and eliminates food retention; harmonizes the stomach.

Indications:
• Any type of food retention, including minerals, metals, bones: fullness, distention in the epigastrium and abdomen, poor appetite, borborygmus, diarrhea. Also appropriate for overindulgence in alcohol and starches.
• Especially effective for stomach cold with food stagnation.
• Can be dry-fried to enhance its effect on food stagnation.
• Added to pills that contain minerals to aid in their digestion and absorption.
• Bensky/Gamble: The ingredients vary – usually a fermented combination of wheat flour, bran, Qing hao, Xing ren, Cang er zi, Chi xiao dou. Liu: Wheat, Xing ren, Chi xiao dou, Qing hao, plus varying local herbs.
MLT: Rich in digestive enzymes.
• Also good for stomach flu.

Dose: 6-15g

Yuan Hua – Genkwa flower – Daphne genkwa

Nature: bitter, acrid, warm, toxic

Enters: Lung, Kidney, Large Intestine

Actions: Eliminates phlegm, stops coughing; strongly eliminates harmful body fluid by purging the bowels and promoting urination; kills fungus (topically).

Indications:
• Premier herb for fluid retention in the chest. In China, 500-1000mg capsules are given 2-3 times daily.
• Retention of harmful fluid: congested fluid in the chest, abdomen, or flanks, edema, ascites, hydrothorax.
• Lung cold and phlegm: cough. Shown to be 91% effective for chronic bronchitis.
• Topical: fungal infection, including ringworm.
• Traditionally forbidden in combination with Gan cao. Recent research suggests that there is in fact an increase in toxicity when these two herbs are combined.
• Fry with vinegar to reduce its toxicity.

Dose: 1.5-3g (generally in powder)

Mang Xiao – Mirabilite – Sodium Sulfate – Glauber’s Salt (Na2SO4)

Nature: salty, bitter, cold

Enters: Stomach, Large Intestine

Actions: Softens masses; clears heat; moistens dryness; purges stagnation and accumulation; reduces swelling.

Indications:

• Excess heat in the large intestine and stomach: constipation (only when the stool is dry and hard).
• Heat: painful, swollen, ulcerated mouth or sore throat, canker sores, red, swollen, painful eyes, carbuncles, swellings, skin lesions, breast swellings – yang type mastitis.
• Use large doses (carefully) to purge the intestines of toxicity for the treatment of all cancers.
• Purgative effect usually takes 4-6 hours.
• Should not be cooked – add to the strained decoction.
• Drink large quantities of fluids when taking this substance.
DY: Drains fire; disperses swelling, stops pain, disperses food accumulation (external use).
• With Da huang for mutual reinforcement, to effectively precipitate full heat and internal accumulation, and free the flow of stools. For specific indications and notes, see Da huang in this category.
• With Ji nei jin to strongly and effectively soften hardness, disperse accumulation, clear heat, and transform stones. For renal, urethral, or bladder lithiasis. Neither substance should be cooked. For greatest efficacy, the two herbs should be ground to a powder (6-10g Ji nei jin and 3-10g Mang xiao) and taken, 6g at a time, twice daily, dissolved in hot water.

Dose: 3-9g

Xuan Ming Fen: a purer form of sodium sulfate
• Less effective as a purgative than Mang xiao, but superior in topical preparations for ulcers of the oral cavity / canker sores.

Yu Li Ren – Bush Cherry Pit – Prunus japonica or P. humulis – “Constrained Plum Pit”

Nature: acrid, bitter, neutral

Enters: Large Intestine, Small Intestine, Spleen

Actions: Moistens the large intestine to promote bowel movement; promotes urination to treat edema.

Indications:
• Dryness or Qi stagnation in the intestines: constipation.
• Edema with abdominal distention or leg qi with difficult urination and constipation.
• Stronger than Huo ma ren at moistening the intestines and promoting bowel movement.
• For stubborn insomnia after a frightening event, this herb is taken as a folk remedy: Decoct it in yellow wine for 10 minutes, then add the drained seeds to an appropriate prescription based on the diagnosis.
• Some patients may get slight cramps in the intestines from this herb.
• Crush before use.
MLT: Contains 60-75% oils which give it its lubricating properties.
Hsu: Emollient laxative, stronger purgative than cannabis; diuretic.

Dose: 3-9g

Zi Wan – Purple Aster Root

Nature: bitter, sweet, slightly warm

Enters: Lung

Actions: Resolves phlegm; stops coughing; descends Lung Qi.

Indications:

• Coughs of various etiologies – including phlegm or Lung deficiency: sticky sputum that is difficult to expectorate, difficulty breathing, or coughing of blood-streaked sputum. Especially for chronic cough or cold-induced cough.
• Can be combined with Bai bu for phlegm that is difficult to expectorate.
• Stronger than Bai bu at resolving phlegm.
• Fry in honey to strengthen its action of moistening the Lungs and stopping coughs.
MLT: Expectorant; antibiotic against E. coli, Shigella sonnei, Pseudomonas aeruginosa, more.
Hsu: Expectorant (increases secretions in respiratory tract), antibacterial (especially against tuberculosis), antiviral, diuretic.

Dose: 3-9g

Zhu Ru – Bamboo Shavings

Nature: sweet, slightly cold

Enters: Lung, Stomach, Gallbladder

Actions: Descends gallbladder and stomach Qi and fire; clears heat; resolves phlegm; stops vomiting; cools the blood, stops bleeding; eases restlessness.

Indications:
• Vomiting: especially due to stomach heat and rebellious stomach Qi; also for other patterns (including morning sickness), when appropriately combined.
• Lung phlegm-heat: cough with thick and yellowish sputum, stifling sensation in the chest, hemoptysis.
• Shen disturbance due to gallbladder and/or stomach heat: restlessness, insomnia.
• Stomach heat: bad breath, aversion to heat, yellow, greasy tongue coat.
• Epistaxis, hematemesis.
• Often fried in ginger juice to mitigate its slightly cold nature.
• Compared to Ban xia, Zhu ru has similar effects and the two are often used together, though Zhu ru is cooling and is better for calming the Shen and alleviating irritability.
Hsu: Strongly antibacterial.
DY: With Ban xia for mutual reinforcement, to effectively dry dampness, clear heat, transform phlegm, harmonize the stomach, and stop vomiting. For such indications as:
– 1. Hiccup, nausea, and vomiting due to counterflow of stomach Qi. (Use ginger-processed Ban xia and ginger mix-fried Zhu ru.)
– 2. Vertigo, agitation, and insomnia due to phlegm turbidity. (Use lime-processed Ban xia and ginger-processed Zhu ru.)
– 3. Nausea and vomiting during pregnancy due to disharmony of the stomach, phlegm-heat, or heat in the stomach. In cases of stomach disharmony, add Zi su geng and Sha ren. In cases of stomach cold, add Sheng jiang and Sha ren. In cases of phlegm-heat, add Pi pa ye. In cases of stomach heat, add Bai mao gen and Pi pa ye.

Dose: 4.5-10g

Zhu Ling – Polyporus umbellatus sclerotium (mushroom) – Grifola umbellatus

Nature: sweet, bland, neutral

Enters: Kidney, Bladder, Spleen

Actions: Strongly drains dampness and harmful body fluid by promoting urination.

Indications:
• Retention of dampness and harmful body fluid: edema, scanty urination, diarrhea, vaginal discharge, cloudy, painful urination, jaundice.
• May be useful in hepatitis B. However, be cautious of damaging the Yin.
• Possible benefit in cancer.
• Much stronger at draining dampness than Fu ling. No tonic effect.
• Caution with Yin deficiency: may cause damage to the Yin (and, as a result, the vision).
• In normal dosage, Zhu ling has shown no significant diuretic effect. In slightly higher dosage, and increase in urine production of up to 62% has been shown. Its effect is thought to take place at the level of the glomeruli.
Hsu: 5g will cause a 62% increase in urine volume in 6 hours.
• Antibacterial.
Research:
• Polysaccharides extracted from the mycelial culture of P. umbellatus and administered intraperitoneally into white mice at a dosage of 300 mg/kg inhibited the growth of Sarcoma 180 and Ehrlich solid cancers by 70% and 80%, respectively (Ohtsuka et al., 1973).
• P. umbellatus was later reported to have antitumor effects in a Japanese study (Ito et al., 1976).
• From the crude drug Chorei, seven components named polyporusterone A, B, C, D, E, F and G, have been isolated. These compounds were cytotoxic to leukemia cells (Ohsawa et al., 1992).
• When combined with the chemotherapeutic agent mitomycin C, Zhuling was shown to increase the lifespan of mice with tumors (You et al., 1994).
• Zhuling was also shown to be useful in reducing the postoperative recurrence rate of bladder cancer. Recurrence rates were 34.9%, compared to 41.7% in the mitomycin C group, and 64.7% in the control group (Yang et al., 1999). Similar results were reported in Yang et al. (1994) and Yang (1991).
• P. umbellatus polysaccharides can offset the immunosuppression of the supernatant from S180 cell culture, which may be mediated by down-regulating the synthesis and/or secretion of immunosuppressive substance by S180 cells (Yang et al., 2004).
• Ergone (ergosta-4,6,8(14),22-tetraen-3-one), an ergosterol derivative isolated from an alcohol extract of P. umbellatus, was shown to be effective in killing various human cancer cell lines. The cytotoxic effects were greatest against the cervical and gastric carcinoma cell lines, but less so against colon and stomach cancer (Lee et al., 2005).
• Cachexia, characterized by loss of weight, muscle atrophy, fatigue, weakness and loss of , is a common condition arising in many human cancer patients, especially those with gastrointestinal or lung cancer. Cachexia is thought to be the most frequent cause of eventual death in such patients. The tumor secretes a compound that breaks down fatty acid tissue in the host, and uses these breakdown products to help grow new cancerous cells. One of these compounds, toxohormone-L, is a protein that also suppresses food and water intake, promoting anorexia in these patients. P. umbellatus polysaccharides were shown to inhibit the cachexia induced by toxohormone-L (Wu et al., 1997).
• Zhuling was originally described in Shen Nong Ben Cao Jing (The Divine Farmer’s Materia Medica Classic) as having diuretic action and was used mainly for edema and dysuria (Wang et al., 1964). Clinical studies have confirmed that Polyporus umbellatus is an effective diuretic, without side effects, for the treatment of pyelonephritis, nephritis and urologic calculi (Wang et al., 1964).
• Aldosterone is a steroid hormone produced by the the adrenal gland, and it regulates sodium and potassium balance in the blood. Ergone has also been shown to have an anti-aldosteronic diuretic effect (Yuan et al., 2004).
• Polyporus umbellatus has been cited a number of times herbal drug used to prevent kidney stones (urolithiasis) (Satish et al., 2006).
• In one study, it was demonstrated that Zhuling in vitro protects red blood cells from 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 50 to 1000 µg/ml. The main free-radical scavengers involved, the triterpene carboxylic acids isolated from the methanol extract, polyporusterone A and polyporusterone B, were found to have inhibitory activities against AAPH-induced lysis of red blood cells. The anti-hemolytic effect was significantly stronger in polyporusterone B compared with polyporusterone A. Furthermore, the ingestion of 150 mg of Chuling was associated with a significant increase in free-radical scavenging effect of plasma in rats (Sekiya et al., 2005).
• It was shown that the polysaccharide extract from P. umbellatus had superoxide and hydroxyl radical scavenging activities. This same report concluded that there was no antioxidative activity in the polysaccharide extract (Liu et al., 1997).
• P. umbellatus was shown to have mitogenic activity on murine lymphocytes in vitro (Yadomae et al., 1979).
• Polyporus umbellatus polysaccharides were found to improve the cellular immunity of normal mice and the mice with liver lesions (Zhang et al., 1991).
• Zhuling, together with mitomycin C, was found to increase the life span of tumor-bearing mice (You et al., 1994).
• A Chinese study found that P. umbellatus polysaccharides can offset the immunosuppression of the supernatant from S180 cell culture, possibly by down-regulating the synthesis and/or secretion of immunosuppressive substance by S180 cells (Yang et al., 2004).
• P. umbellatus extract was shown to promote hair growth in mice, and 3,4-dihydroxybenzaldehyde was isolated as an active component (Inaoka et al., 1994). A later study isolated three hair regrowth substances, acetosyringe and polyporusterone A and B (Ishida et al., 1999). The latter two compounds have been isolated and characterized (Zheng et al., 2004).
• One study investigated the effect of various Chinese herbs, including P. umbellatus, on human scalp hair growth in vitro, using organ culture of human scalp hair follicles. It was found that low doses of extracts (1.28 and 6.4 µg/ml) markedly enhanced the hair growth and lengthened the period of hair growth, while high doses of mixture extracts (4 and 20 mg/ml) sharply inhibited hair growth and shortened the period of hair growth (Sun et al., 2005).
• A group of researchers evaluated various reports about the use of P. umbellatus to treat chronic hepatitis B infection, concluding that the evidence in favor is too weak to recommend using this herb, and that further properly-designed clinical studies are required (Liu et al., 2001).
• Chlamydia trachomatis is the most common bacterial sexually transmitted disease. Worldwide there are estimated to be 50 million new cases of Chlamydia trachomatis infection annually (Black C.M. (1997) Current methods of Laboratory Diagnosis of Chlamydia trachomatis Infections: Clinical Microbiology Reviews. 10(1), 160-184). P. umbellatus, along with several other diuretic traditional Chinese medicines, was found to possess inhibitory activity for urogenital chlamydia trachomatis (Li et al., 2000).

Dose: 6-15g

Sha Ren – Amomum villosum or A. xanthioides – “Sand Seeds”

Nature: acrid, warm

Enters: Spleen, Stomach

Actions: Warms the middle Jiao; promotes Qi circulation; transforms dampness; calms the fetus; stops vomiting; strengthens the stomach.

Indications:
• Dampness and Qi stagnation in the middle Jiao: distending pain in the epigastrium and abdomen, nausea, vomiting, and especially poor appetite.
• Spleen Yang deficiency cold: diarrhea.
• Morning sickness or violent fetal movement.
• Often added to tonic herbs to keep them from causing stagnation.
• Crush before use.
• Short cook – add near the end of cooking a decoction.
Liu: Sha ren is much warmer than Pei lan, Huo xiang, Cang zhu, and Hou po. Caution with heat conditions.
• This herb consists only of the seeds inside the shell – the shell should be discarded unless its properties are intentionally desired.
• The shell – Sha ren ke – is better at promoting Qi circulation, is less warming, and is weaker overall.
Jin: Great herb for women, including in pregnancy.
• Good for liver invading the spleen.
Chen: Used successfully in one study for treating peptic ulcer.

Dose: 1.5-6g (Sha ren ke is dosed at 3-4.5g)

Xi Xian Cao – Siegesbeckia orientalis, pubescens, or glabrescens aerial parts

Nature: bitter, cold

Enters: Liver, Kidney

Actions: Clears heat; eliminates toxicity; eliminates wind-dampness; dispels obstruction from the channels and collaterals; strengthens the sinews; calms the Shen; pacifies the liver; transforms damp-heat; alleviates itching.

Indications:

• Wind-damp: Bi syndrome with numbness, spasms, and weakness in the limbs; facial paralysis, hemiplegia, numbness and weakness in the back and legs. More effective for these indications when processed with wine or (grain-based) liquor.
• Damp-heat-toxicity: carbuncles, boils, eczema, sores, itching. Used both internally and externally for dermatological issues.
• Wind-damp: rash, itching.
• Shen disturbance: irritability, insomnia, forgetfulness.
• Liver Yang rising: headache, dizziness.
• Hypertension: lowers blood pressure.
• Anti-inflammatory
• Acute malaria: use large doses (up to 60g per day).
• Mild antibiotic effect against numerous bacteria
• Topical: soak in this tea for numbness due to dampness.
• Use raw to clear heat and resolve dampness.
• Recently used in many topical “stretch marks” products for its purported ability to heal this form of scarring.

• Likewise, it has recently been employed to break down scar tissue in the fallopian tubes to clear blockage and support fertility.
• Treat with wine for wind-damp Bi.
Hsu: Antibacterial, hypotensive, antiphlogistic.

Dose: 6-15g

Yin Chai Hu – Stellaria Root* (see alternate species) – “Silver Barbarian Kindling”

Nature: sweet, slightly cold

Enters: Liver, Stomach

Actions: Clears Yin deficiency heat; clears fever due to parasites; cools the blood, stops bleeding; reduces childhood nutritional impairment.

Indications:
• Yin deficiency: tidal fever, night sweats, steaming bone disorder.
• Accumulation with heat or parasites: digestive disorders in children with malnutrition, fever, abdominal bloating, thin muscles.
• Heat in the blood: epistaxis, uterine bleeding, bloody cough, hematuria.
• Bensky/Gamble classifies with herbs that clear heat and cool blood.
* Arenaria juncea, Silena jenissensis, and Gypsophila oldhamiama are also used as this herb.

Dose: 3-9g
The ubiquitous Western species – Stellaria media, Chickweed – is used in Western herbalism (aerial parts or whole plant):
Grieve: Refrigerant, demulcent.
K&R: General tonic, cardiotonic. Fire, water, and metal yin.
• Fire: asthenia, hypotension, palpitations, anemia, excellent tonic for convalescents.
Water: edema, glomerulonephritis, nephrotic syndromes, asystole, cardiac weakness, acute articular rheumatism, scarlatina, anemia.
Metal: bronchitis, pleurisy, cough, colds, atonic bowel, strengthens Lung and bronchial tubes, topical for skin conditions, especially burns, hemorrhoids, ulcers.
• A cholesterol cleanser, can be used long term to clear out cellulite for obesity, lipomas and other tumors.
• Also for arrhythmias, depression.
PCBDP: (herb) Antipruritic, vulnerary, emollient, antirheumatic.
• Poultice for eczema, psoriasis, ulcers, boils.
JC: (herb) Demulcent, emollient, nutritive, resolvent, pectoral, alterative, refrigerant, mucilage, discutient.
• Excellent for pulmonary complaints, any form of internal or external inflammation of the membranes or skin, and weakness of the stomach and bowels, especially bleeding of the Lungs or bowels.
• Topical: for wounds, skin diseases, inflamed surfaces, etc.
• Also used as a weight loss aid.

Zi Hua Di Ding – Viola yedoensis – Violet – “Purple Flower Earth Spike”

Nature: bitter, acrid, cold

Enters: Liver, Heart

Actions: Clears heat; eliminates toxicity; clears hot sores.

Indications:
• Heat-toxicity: inflammation, swelling – erysipelas, boils, mastitis, appendicitis, mumps, other hot swellings; red, swollen eyes; swollen, painful throat and ears. Especially useful for boils. Weaker than Pu gong ying for mastitis.
• Hot sores and abscesses – especially of the head and back. Used internally and topically (usually fresh).
• Snake bite: chew and apply topically.
MLT: Softens lumps, including cancer.
• As a syrup: use as an expectorant and to ease sore throats.

Dose: 9-15g
Western Species: It has not been clearly established as to which of the Western species – Viola odorata (Sweet Violet) or V. tricolor (Wild Pansy) – is most similar to the Chinese species, and to what degree.
Hall: (V. odorata) Its root system resembles chains of lymph nodes: clears lymph blockage, lymph cancer (throat), lymph stasis, blood-component changes.
• This herb is a symbol of death of one kind and rebirth in a different dimension.
RW: (V. odorata) Expectorant: chronic bronchitis.
(V. tricolor) Skin conditions: Excellent results with eczema in infants, milk crust and other chronic skin complaints. In adults, chronic eczema will at times respond very well. However, it is necessary to take it for a long time.
• Topical: gauze soaked in the tea can be used for skin complaints, including for tuberculous skin conditions.
K&R: (V. tricolor) Wood yang, metal yin.
Diuretic (volumetric), laxative, depurative, diaphoretic, anticoagulant, antipruritic; tonic to the venous system; anti-allergic and anti-inflammatory properties.
• Skin problems (juvenile acne, herpes, hives, eczematous varicose ulcers, chronic psoriasis, eczema).
• Hemorrhoids, phlebitis, constipation.
• Arthritis, rheumatism with oliguria.

Long Dan Cao – Chinese Gentian Root – “Dragon Gallbladder Herb” – Gentiana scabra, G. triflom, G. manshurica, G. regescens

Nature: bitter, cold

Enters: Liver, Gallbladder, Stomach

Actions: Clears heat and dries dampness from the liver and gallbladder; reduces liver fire.

Indications:
• Liver/gallbladder heat or damp-heat: costal or hypochondriac pain, headache, bitter taste in the mouth, red eyes, diminished hearing, jaundice, leukorrhea, eczema, herpes, itchiness and swelling of the external genitalia. For all damp-heat disorders of the external genitalia.
• Damp-heat in the upper gallbladder channel: red, swollen sore throat and eyes, swollen and painful ears, sudden deafness.
• Liver fire: headache, red eyes, flank pain.
• Liver wind-heat: fever, spasms, convulsions, flank pain.
• Taken (a half hour) before a meal, it increases gastric secretions, taken after a meal, it reduces them.
MLT: Cholecystitis, inflammatory pain, testicle swelling.
• Also for liver wind: spasms, dizziness, fever, convulsions, moving pains and sores on the liver channel.
Hsu: Antiphlogistic, antipyretic.
Yoga: Kirata, Katuki, Trayamana: bitter/cooling/pungent; P, K-; V+
• Bitter tonic, antipyretic, alterative, antibacterial, anthelmintic, laxative.
• For fever, debility after fever, jaundice, hepatitis, enlarged liver or spleen, genital herpes, acne, rashes, obesity, ulcers, venereal sores, diabetes, cancer.
• One of the best anti-Pitta herbs.
• Not to be used when there is no fever or inflammation or high Pitta or excess fat.
• Not for Vata-type debility, nervousness, muscle spasm, hypoglycemia.
RW: (various Euro-Asian species) A pure bitter (the bitter taste is detectable even at a dilution of 1:20,000). Contains no tannin – no astringent or irritant effect. Stimulates gastric secretions and motility and improves tone. It is active as soon as it is absorbed through the mouth’s mucus membranes.
• Caution with a sensitive stomach with excess acid – it can aggravate hyperacidity. Mainly indicated for achylic and atonic conditions.
JC: (G. lutea – Western species) Tonic, stomachic, febrifuge, emmenagogue, anthelmintic (vermifuge), antiseptic, antispasmodic, cholagogue, emetic (large dose), sialogogue, antibilious, antiperiodic, antivenemous.
• One of most valuable bitter tonics and best strengtheners of the human system. Gentian stores vast quantities of condensed oxygen in its roots – the source of its bitterness and exhilarating tonic action. It is a revitalizing tonic and stomachic for physical exhaustion from chronic ailments, general debility, female weakness, digestive weakness, lack of appetite. Intensely bitter, but generally easily received by stomach, wherein it tones the liver without influencing the secretion of bile.
• For atonic gout, amenorrhea, anemia, bites, bruises, cancer (early), chills, chronic indigestion, colds, diarrhea, dizziness, dyspepsia, exhaustion, fainting, fevers, general debility (especially digestive), hysteria, infections, intermittent fevers, jaundice, lameness, liver troubles, malaria, scanty urine, scrofula, side aches, sprains, suppressed menstruation, worms, wounds.
• Common dose for the above indications: 1-2 teaspoons of a strong decoction in a small amount of water, an hour before meals.
• When possible, combine it with an aromatic herb, such as mint.
MW: Can be used for either a lack or excess of hydrochloric acid in the stomach.
• Mental state of the gentian patient: self doubt, depression, lack of good instincts or lack of trust in one’s instincts, panic (as in anaphylactic shock) – pale, sweaty, scared.

Dose: 3-12g

Zi Cao – Zi Cao Gen – Lithospermum or Arnebia Root – “Purple Herb”

Nature: sweet, cold

Enters: Heart, Liver

Actions: Clears heat; cools the blood; promotes blood circulation; promotes the expression of skin eruptions; eliminates toxicity; slight function to moisten the intestines and unblock the bowels; topically clears damp-heat from the skin.

Indications:
• Skin eruptions due to a warm-heat pathogen, heat in the blood, or extreme heat and toxicity in the blood: early measles, chickenpox, eczema, carbuncles, boils, burns. Especially good for dark red or purple skin disorders.
• Heat in the blood: constipation.
• Topical: for damp-heat skin lesions, vaginal itching. Often used in ointment for burns, sores, etc.
• May inhibit ovulation.
• Antineoplastic effects.
• Doctrine of signatures: Its purple color conveys it ability to enter the blood and to treat purple skin eruptions.
JTCM: Its nature is mild. It cools the blood but is not harsh, it moves blood, but not recklessly. It promotes muscle regeneration, clears dampness, heals ulcers, kills parasites and fungus. It can prevent the growth of bacteria and also has anti-inflammatory properties. It promotes blood circulation, growth of the epithelium, and excretion of toxins. It treats allergic purpura due to heat in the blood.
• Treatment of chronic hepatitis B and liver stagnant-heat:
Zi cao treats liver stagnant-heat: dull complexion, liver or spleen enlargement, jaundice, stabbing pain in the liver area, low grade fever, restlessness, burning urination, constipation, bitter taste, dry mouth, dark red tongue with a sticky yellow coat, wiry pulse. This pattern includes chronic hepatitis B (its main pathology is stagnant damp-heat-toxicity). Experiments show the herb has activity against the hepatitis B virus. It also treats cirrhosis and ascites.
To treat chronic liver stagnant-heat, combine Zi cao with Mu dan pi, Chi shao, Shan zha, Hu zhang, Bai jiang cao, Ku shen, Chai hu, Yu jin, Yin chen hao. Add Huang qi and Tai zi shen if there is Qi deficiency. Add Nu zhen zi and Sheng di if there is Yin deficiency.
Zi cao oil for neurodermatitis:
Zi cao oil: Soak Zi cao in sesame oil (1 part herb : 2 parts oil) for 15 days. Strain the oil. Apply it to rashes 3-6 times/day.
Treats neurodermatitis (skin rash due to nervous system disorder, including with severe paroxysmal itchiness).
Zi cao for retinal phlebitis and other eye problems:
Zi Yun eye drops: Decoct 500g each of Zi cao and Dang gui for 15 minutes. Strain. For each liter of the fluid: Add 1kg Feng mi. Cook for another 10 minutes. Strain. Add 100g Bing pian and 3g She xiang.
Drop into the eyes three times daily.
Treats retinal phlebitis (including blindness caused by it), cataracts, bleeding of the eyes.
While applying the above eyedrops, give this formula internally:
Zi Lan Tui Yi Tang: Zi cao, Ban lan gen, Mu zei, Chan tui, Huang qi, Pao jia pian. In 30 days, the symptoms of 85% of patients are controlled. 95% of patients recover in 90 days.
Zi cao for festering otitis media:
Zi cao oil #2: soak 100g Zi cao in 1kg sesame oil. Cook over low heat until the Zi cao becomes charcoal colored.
Treats festering otitis media. To use, clear any pus from the ear with 3% hydrogen peroxide. Apply 3-4 drops of oil into the ear 4-5 times/day. Complete recovery usually takes 3-7 days.
Can be used for both acute and chronic ear conditions.
Zi cao for burns:
Zi Yun Gao: melt 150g beeswax. Add 30g each of Zi cao and Dang gui, and 500 mL sesame oil. Cook until the oil changes to a reddish-purple color. Strain, cool.
Apply to burns – especially first and second degree.
Zi cao for chronic ulcers:
Zi Cao Gao: soak Zi cao (30g), Dang gui (15g), and Chuan jiao (3g) in 300 mL sesame oil for 24 hours. Bring to a boil. Add Chuan shan jia (9g). Strain. Add 60g beeswax. Allow to cool.
Apply topically to chronic ulcers: Sterilize the surface of the ulcer. Apply Zi Cao Gao. Cover with gauze. Use a hot water bottle to warm it for 20 minutes, twice a day. Change the gauze once daily. Ulcers usually heal in 14 or fewer applications.
K&R: (L. officinalefruit, leaves, flowers) Diuretic, emmenagogue, inhibits pituitary gonadotropins [FSH and LH], TSH antagonist.
• Wood yang, fire yang, earth yang:
Wood: biliary dyskinesia, urinary and biliary calculi, hyper-folliculine dysmenorrhea, mastosis, mastitis, hot flashes, spastic colon.
Fire: excess pituitary hormone secretion, especially inhibits FSH and LH.
Earth: hyperfolliculine dysmenorrhea, PMS.
RW: (various Lithospermum species) Contraceptive: antigonadotropic, anovulatory actions. Like oral contraceptives, it blocks the gonadotropic hormones of the anterior pituitary. Only reliable after prolonged use. Still does not reach the almost total efficacy of the contraceptive pill. Taken as a daily infusion by American Indian women for a period of six months to ensure infertility.

Dose: 3-9g

Zhi Zi – Shan Zhi Zi – Gardenia Fruit – Cape Jasmine Fruit

Nature: bitter, very cold

Enters: Heart, Lung, Stomach, San Jiao, Liver

Actions: Clears heat in all three Jiaos; mildly drains dampness; cools the blood; stops bleeding; eliminates toxicity; reduces fire from the heart, Lungs, and stomach to ease restlessness; topically reduces swelling and blood stasis due to trauma.

Indications:
• Heat in the Lungs, stomach, or heart: restlessness, irritability, fever, stifling sensation in the chest, insomnia, delirious speech.
• Liver/gallbladder damp-heat (and constraint): jaundice, fever, scanty urination.
• Lower Jiao damp-heat: painful urinary dysfunction.
• Damp-heat in the gallbladder and san jiao channels of the face, affecting the nose and eyes or causing sores in the mouth or facial region.
• Heat in the blood: hematemesis, hematuria, hemafecia, epistaxis. Usually partially charred for this use.
• Topical: powder the herb and mix it with egg white or vinegar for swelling and blood stasis due to trauma.
• Increases contraction of the gallbladder 20 to 40 minutes after ingestion.
• A paste made of ground Zhi zi, water, and alcohol was used in an uncontrolled study of 407 acute sprains. The paste was changed every 2-5 days. 80% of patients had no pain within 24 and 97% were pain free within 48 hours. Swelling and restoration of function were also improved.
• Though Wei Li freely uses 9g/day, Guohui Liu is often more conservative with the dosage, cautioning that it is very bitter and cold and can nauseate some patients.
• This herb should be pounded before cooking.
• Partially char the herb when using it to cool the blood and stop bleeding.
Chao zhi zi is Zhi zi which is dry-fried until it turns yellow. It is less likely than plain Zhi zi to cause nausea or vomiting.
Li: Can lower the body temperature.
MLT: Also promotes blood circulation; relieves pain.
• Liver damp-heat: jaundice, hepatitis, boils, sores.
• Sometimes called the “happiness herb” because it relieves irritability associated with heat and liver stagnation.
Hsu: Cholagogue, lowers blood bilirubin; hypotensive; antibacterial.
DY: This is one of the bitterest substances in the Chinese pharmacopeia.
• The outer layer (epicarpium) of Zhi zi (Shan zhi ke) moves blood and clears external heat. The seeds inside (Shan zhi ren) clear internal heat. The seeds with the epicarpium are superior for draining Lung fire. The seeds without the epicarpium are superior for draining heart fire.
• With Dan dou chi, the two herbs unite to form the clearing and diffusing and out-thrusting method to eliminate evils from the exterior and interior. Together, they effectively promote perspiration, drain evils from the exterior, clear and out-thrust heat from the interior, and eliminate vexation due to full heat. For indications such as:
– 1. Vexation and agitation, insomnia, and irritability during or after a warm disease. (Zhi Zi Chi Tang) Use stir-fried Dan dou chi.
– 2. External contraction of wind-heat or a febrile disease.

Dose: 3-12g

Herbs That Clear Summer Heat

I learned single herbs from Guohui Liu, who didn’t emphasize this as a unique category. Most of the herbs that clear summer-heat have other significant functions and may be assigned to these categories instead. Summer-heat attack, depending on where one lives, may be quite rare. Following is a list of herbs that clear summer heat which can be found in other categories in this book and also full descriptions of a few herbs that clear summer-heat as (perhaps) their most significant action.

• Bai bian dou (Qi Tonic)

• Che qian zi – treats diarrhea due to summer-heat (Herb that Drains Dampness)

• Dong gua pi – treats edema due to summer-heat (Herb that Drains Dampness)

• Hua shi (Herb that Drains Dampness)

• Huo xiang (Aromatic Herb that Transforms Dampness)

• Ju hua (Acrid, Cool Herb that Releases the Exterior)

• Lian fang (Herb that Stops Bleeding)

• Pei lan (Aromatic Herb that Transforms Dampness)

• Qing hao (Herb that Clears Deficiency Heat)

• Ren shen ye – see Ren shen section (Qi Tonic)

• Tai zi shen – treats unrelenting summer-heat in children (Qi Tonic)

• Xiang ru (Acrid, Warm Herb that Releases the Exterior)

Herbs That Clear Summer-Heat as Their Prevailing Action:

He Ye – Lotus leafNelumbo nucifera Particularly suited for treating diarrhea due to summer-heat. Also frequently used to promote weight loss.
(Da) Dou Juan – Soybean sprout  • Sweet, acrid.
• Clears heat; drains dampness; clears summer-heat.
• Early stages of summer-heat or warm-febrile diseases, especially those with joint pain, sensation of heaviness, minimal swelling, and a greasy tongue coating due to the presence of dampness.
• Bensky/Gamble classifies with herbs that clear summer-heat.
MLT: Sprouted form is used for rheumatic conditions, edema, swelling of the whole body and knees.
Lu Dou – Mung BeanPhaseolus Particularly suited for treating thirst due to summer-heat. Also used to detoxify toxic herbs and for overdose of toxic herbs.
Xi Gua – Watermelon fruit Particularly suited for treating thirst and scanty urine due to summer-heat. The white part (“watermelon frost” is coldest).

Zi Su Ye – Perilla Leaf – “Purple Relaxing Leaf”

Nature: acrid, warm

Enters: Lung, Spleen

Actions: Releases exterior syndromes by dispersing cold (mild); eases distention of the chest and epigastrium; promotes Qi circulation, expands the chest; alleviates seafood poisoning; calms a restless fetus, alleviates morning sickness.

Indications:

• Wind-cold: fever, aversion to cold, headache, nasal congestion, cough, chest discomfort or stifling sensation in the chest.
• Spleen and stomach Qi stagnation: distended chest, vomiting, morning sickness, poor appetite, nausea, bloating.
• Seafood poisoning: abdominal pain, vomiting, diarrhea.
• Morning sickness: best to use the stem (Zi su geng) rather than the leaf.
• Its ability to release the exterior is mild compared to Ma huang and Gui zhi, but it is stronger than Jing jie and Fang feng at dispersing cold.
• Excellent for treating turbidity.
• Short cook.
Hsu: Extract prolongs duration of sleep.
HF: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas (key herb in Su He Tang).
Li Dong Yuan: Upbears Yang Qi.
DY: Zi su (the leaves [Zi su ye] and stems [Zi su geng] of Perilla) can be combined with Huang lian to clear stomach heat, dry dampness, rectify the Qi, and stop vomiting. For the following indications, ginger mix-fried Huang lian should be used:
– 1. Vomiting and nausea due to stomach heat or damp-heat in the middle burner along with Qi stagnation in the middle burner.
– 2. Vomiting during pregnancy due to heat or damp-heat along with Qi stagnation in the middle burner.
Zi su geng (the stem) moves the Qi, opens the center, rectifies the Qi, quiets the fetus, and particularly treats vomiting due to pregnancy, threatened miscarriage, and epigastric or abdominal distention.
Zi su ye and Zi su geng are often combined and added to formulas to treat plum pit sensation or wind-cold attacks with food stagnation or vomiting.
BF: The contemporary standard description of Perilla is that it is acrid and warm, it enters the Lungs and spleen, and its functions are to effuse the exterior, scatter cold, rectify the Qi, and harmonize the constructive. It treats wind-cold flu, aversion to cold, emission of heat, cough, qi panting, chest and abdominal distention and fullness, and restless stirring of the fetus.
While all the sources quoted in the Zhong Yao Da Ci Dian (Large Dictionary of Chinese Medicinals) say that this medicinal is acrid and warm, the Ben Cao Yan Yi (Amplified Meaning Materia Medica) says that Perilla is only slightly acrid and also sweet. The Ben Cao Jing Shu (Oversights in the Materia Medica Classic) says its enters the hand Shaoyin and Taiyin and the foot Yangming, while the Ben Cao Jing Jie (Explaining the Materia Medica Classic) says it enters the foot Jueyin and hand Taiyin. In terms of functions and indications, the Ri Hua Zi Ben Cao (Ri Hua-zi’s Materia Medica) says it supplements the center and boosts the Qi as well as frees the flow of the large and small intestines. The Ben Cao Tu Jing (Illustrated Materia Medica Classic) says it frees the flow of the heart channel and boosts the spleen and stomach. These other historical opinions suggest there is more to Perilla than its just resolving the exterior and downbearing upwardly counterflowing Lung and stomach Qi.
Restless fetal stirring refers to lower abdominal pain with leakage of blood from the vaginal meatus and low back pain during pregnancy. These are symptoms of threatened miscarriage. Most threatened and/or unstoppable miscarriages in my practice are due to insufficient production of progesterone. This usually goes hand in hand with a luteal phase deficiency and is, in my opinion, commonly due to autoimmune ovaritis. Such luteal phase deficiencies and progesterone insufficiencies in 35-50 year old Western women are overwhelmingly accompanied by signs and symptoms of spleen Qi-kidney Yang vacuity complicated by liver depression and possible damp heat, depressive heat, and/or blood stasis, and it is very interesting to me that Perilla is accepted as an empirically effective Chinese medicinal for quieting the fetus – something one would not expect from an exterior-resolving herb.
The Ben Cao Tong Xuan (The Mystery-penetrating Materia Medica) says that Perilla may discharge (drain) a person’s true Qi if administered for a long period of time. Resolving the exterior means to promote sweating and sweating always results in a loss of true Yin and Yang Qi.
However, when combined with Mume, this medicinal’s negative effects of discharging and draining are counterbalanced. As an exterior-resolving medicinal, Perilla is contraindicated in Yin vacuity patterns for fear of further damaging Yin fluids, but Mume engenders fluids. Likewise, over-effusing and out-thrusting can damage the Yang qi, but Mume’s astringing and securing of the Lung Qi prevents this.

Dose: 3-9g

Sheng Ma – Cimicifuga (Actea) rhizome – “Ascending Hemp”

Nature: acrid, sweet, slightly cold

Enters: Lung, Spleen, Large Intestine, Stomach

Actions: Guides upward; releases exterior syndromes; expresses skin eruptions; clears heat and eliminates toxicity; lifts Yang Qi.

Indications:
• Wind-heat: headache; slow skin eruption in early-stage measles.
• Heat and toxicity: headache, swollen and painful gums, canker sores, sore teeth, ulcerated lips or gums, painful and swollen throat, sores, blotches (febrile disease).
• Spleen Qi sinking: prolapse (rectum, uterus, etc.), shortness of breath, fatigue.
• Spleen Qi deficiency and failure to control the blood in the vessels: uterine bleeding.
• Stomach heat: toothache (raises Yang and relieves heat toxicity).
• Often used with Ge gen to promote expression of rashes.
• Often used with Chai hu to lift the Yang Qi.
• Stronger than Chai hu at lifting prolapsed organs.
• Note that the herb Serrulata is often substituted for Cimicifuga.
• Guides other herbs upward.
• Fry in honey to lift spleen Qi.
Heiner Fruehauf: A San Du, scattering toxin medicinal, typically found in Gu Zheng (Gu parasites) formulas.
Dui Yao (Sionneau & Flaws): Upbears Yangming and clear spleen Qi; frees the flow of Qi on the right side of the body.
• In combination with Chai hu for mutual reinforcement, to upbear liver, stomach, and spleen Yang Qi. See Chai hu in this category for indications and notes on this combination.
• With Sheng ma to resolve the exterior and muscle aspect, clear heat, resolve toxins, and out-thrust rashes over the whole body. See Ge gen in this category for specific indications and notes.
Sheng ma is stronger than Ge gen at upbearing Yang. Moreover, Sheng ma is used for all types of Qi fall in the middle burner, such as ptosis of the organs, rectal prolapse, uterine prolapse, shortness of breath with a feeling of collapse in the chest, chronic diarrhea, and persistent metrorrhagia.
• Sheng ma is a messenger medicinal which guides the action of other medicinal substances toward the upper part of the body – the head, face, and upper orifices – and toward the Yangming. Therefore, it is used to treat toothache, oral ulcers, and stomatitis associated with the stomach, and constipation associated with the large intestine [I assume he means by clearing excess from the Yangming].
Hsu: Anti-ulcerative, anticonvulsant, analgesic, antipyretic.

Dose: 1.5-9g

Of the Western species, Cimicifuga racemosa:
It has not been clearly established how much the Chinese and Western species have in common, although they have been shown to contain many of the same chemical constituents. It seems that Black Cohosh possesses Sheng Ma’s exterior releasing and analgesic qualities (and may even be stronger), but Sheng Ma does not necessarily possess the hormone modifying qualities of Black Cohosh. Since Serrulata species are a very common adulterant for Sheng ma, unless you are sure you are getting some kind of Cimicifuga, Sheng ma certainly cannot be counted on for the following actions and indications.
Kenner & Requena:  Antispasmodic (musculotrope and neurotrope), sedative, sympatholytic, vagolytic, LH antagonist. Pungent-cooling; wood yang.
Wood: headaches – migraine, ophthalmic headaches, cluster headaches, hypertension, vertigo, Meniere’s, neuralgia, spasmophilia, menstrual cramps, menopausal complaints incl. depression, anxiety, hot flashes, vaginal dryness and atrophy.
• Also for genital herpes, asthma, pertussis, anxiety, panic attack, facial neuralgia, rheumatic pain, relieves tension in shoulders and occiput along the gall bladdder channel.
• Careful with the use of this herb for a true migraine – can induce vomiting.
John Christopher: Nervine; emmenagogue; antispasmodic; alterative; diuretic; astringent; expectorant; diaphoretic; arterial and nervine sedative; cardiac stimulant-slightly depresses heart rate while increasing force of pulse and equalizing circulation; stomachic-tonic; antiseptic; antivenomous; muscular: for rheumatism, arthritis, neuralgia; tonic to mucus and serous tissues; stimulates secretions of liver, kidneys, and lymphatics.
• Pelvic disturbances, uterine disorders – contracts the uterus, increases menstrual flow.
• Acute chronic pulmonary and bronchial affections.
• Parturition: initiates uterine contractions, checks hemorrhage, allays nervousness and afterpains of delivery.
• Hypertension, palpitations, hemorrhage, uterine contractions: use full dose.
• Smaller dose for insomnia, headache, indigestion, bronchitis…
• Use as a syrup for colic, convulsions, nerve disorders, cough, whooping cough, liver and kidney disorders.
• Overdose can produce nausea and vomiting.
Matt Wood: A black, tangled mass of roots: for those caught in state of brooding, dark hopelessness, entangled in a web of coercive forces, against which one fights, but feels cannot ultimately defeat; a sense of entrapment; maybe caught in an abusive relationship or manipulative business pattern.
• For those who need to grab hold of their fears and drives in order to get through the entanglement which surrounds them.
• Gives the confidence to go through the black states of mind.
• Known as the “Herbal Chiropractor” – for spine problems/pain and head pain, especially when worse with menstruation.
Yoga of Herbs (Frawley & Lad): Bitter, pungent/cooling/ pungent
• Reduces Pitta and Kapha; elevates Vata
• Alterative, emmenagogue, antiseptic.